Document MGk5x213VpyG9npGK5L2J8Oea

Younger Laboratories INCORPORATED 13 3 CLIir CAVE TIOAO SAINT LOUIS. MO,, 63139 THOMS IIIIMI14HI Toxicologic Invtitigttion of MCS 1547 Lot Nucnbor 001-NW207155 Data 10/2/73 To l Mo naanto Company t. Loitli) Missouri 63166 Prajoet No. T-73-112 ACUTE ORAL TOXICITY Spacitt SpragUfDavlsy Albino Rata LD50 2,370 Mf/K| 95% ConliOanct Litnlti 2250 2450 CONDITIONS Fed Undllutad * Slnfla Oral Dost Mg/Kg Dowf* Ma'xa 2000 2:i0 ,3 3160 I a 3900 innwi ****'! Mala f 220 215 220 225 240 225 210 220 M* umni/OtiM Md* fmni Cemtomod 0/2 1/3 1/5 1/3 2/2 3/5 2/2 1/3 3/5 2/3 2/2 4/5 Tim or Mommy One to thraa days t fl s*n, of inrca.c*: on Reduced appetite and activity (on* to thraa day* In survivors), increasing weakness, collapse, and daatiu Croll AuIOMv UccaCenU Lung and liver hyperemia and acuta gastrointestinal inflammation. Suitivoh t 7 Oayti Viscera appeared normal ACUTE OERMAL TOXICITY *>< New Zealand Albino Rabbit* LO^O CONDITIONS ^ 2,0C'0 Mg/K| 95% Conlidanc* Limit, Applied Undiluted - 26 hour* exposure -- Mg/Kg uto 2000 3160 5010 Inrttoi DMd Mti f tmoii Mlf Fimod Comb'rttd Tim* o> Monthly 2__.5 2.4 2.6 Mm 2*3 0/1 mmm 0/1 0/1 0/1 1/1 1/1 i/i 1/1 1 Day 2 Day* I Reduced appaclta and activity (on* to two day* In survivors), S'C'* ol inioitcacan increasing weakness, collapse, and death* Gton Auiooiv OtcrAi, llenorrhaglc arass of the lunn* and ltvar, slightly enlarged gall bladder, and gastrointestinal Innomatlon. SulvivOO 14 Dtyll Viscera appearad normal* MOMS 02157S T A* Aia<Si>|l ' , a )f] A V* wad IA ISiBemia| (A* grpwci #n* rv>ay fra f<*an i* al*e *** n* < u*'