Document MGexo04x6Medr9o26e5B5nBzy

CONFERENCE on BIOLOGICAL EFFECTS OF ASBESTOS Monday, October 19, Tuesday, October 20, and Wednesday, October 21, 1964 THE NEW YORK ACADEMY OF SCIENCES SECTION OF BIOLOGICAL AND MEDICAL SCIENCES 2 East Sixty-third Street New York, N. Y. 10021 The evening session on October 20 vill be held at the Academy Building ALL OTHER SESSIONS WILL BE HELD AT The Waldorf-Astoria Park Avenue at 50th Street New York, N. Y. program witt aarnr* as a ticket ot admtaalcn and Is nontransiorabta. r>- .I \ t oasArco euP Preface of the Conference In the four decades during which there has been acceptance of potential hazards associated with exposure to asbestos, solutions to the problems involved have been elusive. Therapy of asbestosis remains largely a rearguard holding action once the diffuse interstitial fibrosis is established. Prophylactic measures are hampered by difficulties in early diagnosis, including the long latent period often noted between onset of exposure and clinical change. Hard won data have been accumulating which indicate that neo plasia associated with asbestos exposure, especially those of the lung, are perhaps the most important industrial cancers at this time. This importance has been emphasized by the recent stimulating studies of South African and British .investigators demonstrating the significant incidence of pleural and peritoneal .tumors associated with asbestos exposure and by the knowledge that the various neo plasms might follow exposure of limited duration and intensity, in adequate to result in significant asbestosis. There have been effective advances in dust control techniques, accomplished by diligent, ingenious and expensive engineering. However, application of these procedures has been hampered by the rapid growth of asbestos utilization, sometimes under circum stances in which exposure has been obscure or unrecognized. More over, community and indirect occupational exposure may occur; the scope and importance of such "asbestos air pollution" are at pre sent uncertain but their potential significance has attracted atten tion. The foregoing sober inventory provided the stimulus and back ground for this Conference. The Scientific Council of the Academy considered that the interdisciplinary nature of the problem, involving such distinct fields as exoerimental pathology, applied physiology, oncology, epidemiology, and industrial hygiene could best be served by a broad conference of investigators in the biological sciences and those in allied fields. In October 1963 visits were made by Dr. Selikoff on behalf of the Academy to several European centers to investigate the feasibility and potential scope of such a conference. In particular, British studies were reviewed with Dr. J, C. Gilson, Director of the .Medical Research Council Pneumoconiosis Research Unit. The cooperation of Dr. H. Heimann of the Division of Occupational Health of the United States Public Health Service facilitated a survey of current work in this country. The Academy was forti ference Committee whi-` Its members, themselve. January 6, 1964 in New Yo then formulated was refine Committee with the assistai of the world and by July, pleted. It is the hope of the f fertile one and will lead problem. July 17, 1964 Irving J. Selikoff Jacob Churg, W. Clark Cooper John C. Gilson ORGAt' Coc Yor Coc Yor Sch orn- -e E. Cuyler Hammond Thomas F. Mancuso E. Lynn Schall William E. Smith Amt Gra of 1 j Occ j Sta j He: | sor | j i ASARCO ELP 0002856 acceptance of stos, solutions holding action . Prophylactic isis, including exposure and icate that neov those of the s at this time, nt stimulating demonstrating ors associated a various neo intensity, in- >i techniques, engineering, hampered by under circum- gnized. Morelay occur; the i" are at pretracted atten- .us and backthe Academy em, involving d physiology, :st be served cal sciences behalf of the le feasibility ular, British f the Medical * cooperation lealth of the ey of current The Academy was fortunate in securing the advice of a Con ference Committee which encompassed the major areas involved. Its members, themselves actively concerned with the problem, met January 6, 1964 in Mew York. The preliminary design of a meeting then formulated was refined during the succeeding months by the Committee with the assistance of active investigators in many parts of the world and by July, 1964 the Conference program was com pleted. It is the hope of the Academy that this Conference will be a fertile one and will lead to decisive findings on this important problem. July 17, 1964 Eunice Thomas Miner Executive Director The New York Academy of Sciences ORGANIZING COMMITTEE Irving J. Seiikoff Jacob Churg, W. Clark Cooper John C. Gilson E. Cuyler Hammond Thomas F. Mancuso E. Lynn Schall William E. Smith Cochairman; The Mount Sinai Hospital, New York, N. Y. Cochairman; The Mount Sinai Hospital, New York, M. Y. School of Public Health, University of Calif ornia, Berkeley, Calif. Pneumoconiosis Research Unit, Medical Re search Council, Penarth, Glamorgan, Wales American Cancer Society, New. York, N. Y. Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pa. Occupational Health Program, New Jersey State Department of Health, Trenton, N. J. Health Research Institute, Fairleigh Dickin son University, Madison, N. J. i | ! { t 1 i l : :; i t 1tI 1 ASARCO ELP 0002857 Conference Cochairmen: I. J. Selikoff and J. Churg The Mount Sinai Hospital New York, N. Y. PROGRAM MONDAY, OCTOBER 19, 1964 Session Chairman: H. J. Magnuson Institute of Industrial Health, University of Michigan Ann Arbor, Mich. 9:00 A.M. Greetings from the Academy - Gabriel G. Nahas, Vice-Chairman, Section of Biological and Medical Sciences, The New York Academy of Sciences: College of Physicians and Surgeons, Columbia Uni versity, New York, N. Y. Opening Remarks -- I. J. Selikoff, The Mount Sinai Hospital, New York. N. Y. ASBESTOS MATERIALS IN MODERN TECHNOLOGY Session Cochairman: P. H. Riordon Asbestos Corporation Limited Thetford Mines, Quebec "The Geology, Occurrences and Major Uses of Asbestos" -- N. W. Hendry, Canadian Johns-Manville, Ltd., Asbestos, Quebec. "Physical and Molecular Structure of Asbestos" -- R. Gaze, The Cape Asbestos Company, Ltd. (Asbestosis Research Council), London, England. LIVING TISSUE AND MINERAL MATTER: PROBLEMS OF PATHOGENESIS Session Cochairman: I. Webster Pneumoconiosis Research Unit Johannesburg, South Africa PROBLEMS OF IDENTIFICATION OF ASBESTOS IN HUMAN TISSUE: PANEL DISCUSSION MODERATOR: P. Gross, Industrial Hygiene Foundation, Pittsburgh, Pa. "Identification bActivated Oy.-- - Mount Sinai 1' , "Identification o Human Lung Ti: College of Medic "Dust Content a G. Nagelschmidt Sheffield, Englan EX MODERATOR: J. C coniosis Researc "Asbestos Dust Wagner and J. W Unit, Glamorgan, "Experimental A tance of Particle Research Counc "Electron Micro mals" -- J. M. G versity of Cambr "Rheumatoid Factor B. Pernis and E. C. I. J. Selikoff, The M "Observations t: Ifani and B. Pen...,, 12:30 P.M. Luncheon HUM AS3ESTC : Ses j M.R.C ! 2:00 P.M. "Asbestosis in the Pensions and Nation 1 l ? 1 ti ASARCO ELP 0002858 n: ital . 1964 agnuson sxsity at Michigan '. Nahas. Vice-Chairman, The New York Academy Surgeons, Columbia Uni- >unt Sinai Hospital, New ?N TECHNOLOGY Riordon mited ec es r sbestos" -- N. W, :bes.. ., Quebec, bestos" -- R. Gaze, The osis Research Council), .L MATTER: GENESIS Vebster ' ch U nit vfrica OF ASBESTOS IN ISCUSSION ie Foundation, Pittsburgh, "Identification by Fluorescent Oye Staining and Electronically Activated Oxygen Ashing" -- C. Berkley and J. Churg, The Mount Sinai Hosoital, New York, N. Y. "Identification of the Several Varieties of Asbestos Fibers in Human Lung Tissue" -- A. Vorwald, Wayne State University College of Medicine, Detroit, Mich. "Dust Content and Composition in Lungs with Asbestosis" -- G. Nagelschmidt, Safety in Mines Research Establishment, I Sheffield, England. EXPERIMENTAL ASBESTOSIS PANEL DISCUSSION MODERATOR: J. C./Wagner,)Medical Research Council Pneumo-^Q coniosis Research''tfttitrGlamorgan, Wales. "Asbestos Dust Deposition and Retention in Animals" - j. C. i | Wagner and J. W. Skidmore, M.R.C. Pneumoconiosis Research Unit, Glamorgan, Wales. "Experimental Asbestosis with Three Types of Fibers: Impor tance of Particle Size" - J. Mills and P. F. Holt,(Asbestosis Research Council), University of Reading, Reading, England. "Electron Microscooic Studies of Asbestosis in Man and Ani mals" -- J. M. G. Davies, (Asbestosis Research Council), Uni versity of Cambridge, Cambridge, England. "Rheumatoid Factor in Serum of Individuals Exposed to Asbestos" B. Pernis and E. C. Vigliani, University of Milan, Milan, Italy, and I. J. Selikoff, The Mount Sinai Hospital, New York, N. Y. j j j "Observations on the Pathogenesis of Asbestosis" E. C. Vig- ; liani and B. Pernis, University of Milan, Milan, Italy. 12:30 P.M. Luncheon Session Chairman: J, H. Sterner Eastman Kodak Company Rochester, N. Y. HUMAN EXPOSURE TO ASBESTOS: ASBESTOSIS IN INDUSTRIAL POPULATIONS Session Cochaiman: J. C. Gilson M.R.C. Pneumoconiosis Research Unit Glamorgan, Wales 2:00 P.M. "Asbestosis in the United Kingdom" -- J. C. McVittie, Ministry of Pensions and National Insurance, London, England. ASARCO ELP 0002859 ``Asbestosis Among Insulation Workers in the United States" -- I. J. Seiikoff, J. Churg, and E. C. Hammond, The Mount Sinai Hospital, New York, N. Y. ``Mortality Rates Among Asbestos Products Workers in the United States" -- P. Enterline, U. S. Public Health Service, Washington, D, C. ``Secular Changes in Asbestosis in an Asbestos Factory" -- W. J. Smither, (Asbestosis Research Council), The Cape Asbestos Com pany, Ltd., London, England. HUMAN EXPOSURE TO ASBESTOS: COMMUNITY STUDIES Session Cochairman: J. Higginson University of Kansas School of Medicine Kansas City, Kan. ``Occupational and Nonoccupational Exposure to Asbestos" -- W. C. Hueper, National Cancer Institute, Bethesda, Md. ``Prevalence of Asbestos 3odies in Autopsy Cases" -- J. C. Thom son, University of CapeTown, CapeTown, South Africa. ``Asbestosis: Geographical and Environmental Studies in South Africa" -- G. K- Sluis Cremer, Pneumoconiosis Bureau, Johannes burg, South Africa. ``Pleural Plaques and Asbestos: Further Observations on Endemic and other Nonoccupational Asbestosis" -- R. Kiviiuoto, Tampere Central Hospital, Tampere, Finland. Session Chairman: J. H. Wolfsie s~\j\United States Rubber Company 'i y jfe (J u^/New ^or^t Y. . ij/' / //>'Tv'y3ession Cochairman: L. Cralley , y^S.P.H.S. Occupational Health Research and Training Facility Cincinnati, Ohio ($:0Q P.M. - hrtraTaTIon of Fibrous Dusts" -- V. Timbrell, M.R.C. Pneumo coniosis Research Unit, Glamorgan, Wales. ``Comparison ofTmpinger and Membrane Filter Techniques for Eval uating Air Samples in Asbestos Plants" -- H. E. Ayer, Division of Occupational Health, U. S. Public Health Service, Washington, D. C. "Developments in Dust Sampling and Counting Techniques in the Asbestos Industry" - S. Holmes, (Asbestosis Research Council), Turner Brothers Asbestos Company, Ltd. Rochdale, England. "Dust Measurem C. G. Addingley and Asbestos "Measurement of Different Parame Topical Medicine Discussion oper burgh. Pa. S jersey State Dept ``Economics of D NCouncil), Turner land. Schoo "Radiological C'. Municipal Hospits "Roentgenologies l. J. Seiikoff, The "Differential Dia Welsh National 5 "Roentgenologic tosis in the Unit' 3rompton Hospit National Insurant Theron, I ueumoc Disscussion open ford Mines, Quebt Johannesburg, So: ASARCO ELP 0002860 n the United States" -- I. J. The .Mount Sinai Hospital, act. orkers in the United ealth Service, Washington, Asbestos Factory" -- W. J. , The Cape Asbestos Com- COMMUNITY STUDIES Higginson )1 of Medicine an. :posure to Asbestos" -- W. thesda, Md. oosy Cases" -- J.C.Thom- South Africa. onmental Studies in South roniosis Bureau, Jonannes- r Observations on Endemic " -- R. Kiviluoto, Tampere . d. V i Company .. Cralley .rch and Training Facility io rimbreli. M.R.C. Pneumoes. Filter Techniques for Eval' -- H. E. Ayer, Division of i Service. Washington, D.C., Counting Techniques in the estosis Research Council), . Rochdaie, England. "Dust Measurements and Monitoring in the Asbestos Industry"C. G. Addingley, (Asbestosis Research Council), British Belting and Asbestos, Ltd., Yorkshire, England. "Measurement of Airborn Asbestos Dust by Instruments Measuring Different Parameters" -- S. A. Roach, London School of Hygiene and Topical .Medicine, University of London, London, England. Discussion opened by T. Hatch, University of Pittsburgh, Pitts burgh, Pa. TUESDAY, OCTOBER 20, 1964 '' , /Atfui Session Chairman: Harriet L. Hardy /") Massachusetts Institute of Technology Cambridge, Mass. - JUST CONTROLS AND STANDARDS J:00 A.M. - "Present Threshold Limit Value in the U. S. A. for Asbestos Dust: A Critique" - E. L. Schall, Occupational Health Program, New Jersey State Department of Health, Trenton, N. J. '`Economics of Dust Control" - D. W. Hills, (Asbestosis Research '''Council), Turner Brothers Asbestos Company, Ltd., Rochdale, Eng land. Session Cochaitman: L. Silverman School of Public Health, Harvard University Boston, Mass. PULMONARY ASBESTOSIS "Radiological Classification of Pulmonary Asbestosis" -- H.3ohlig, Municipal Hospital, Ludensheid, Germany. "Roentgenological Studies of Pleural Calcification in Asbestosis" -- I. J. Selikoff, The Mount Sinai Hospital, New York, N. Y. "Differential Diagnosis in the Pathology of Asbestosis" -- J. Gough, Welsh National School of Medicine, Cardiff, Wales. "Roentgenological-Pathological Correlations in Pulmonary Asbes tosis in the United Kingdom and South Africa" -- K. F. W. Hinson, Brompton Hospital and J. C. McVittie, Ministry of Pensions and National Insurance, London, England; G. K. Sluis Cremer and C. P. Theron, f ueumoconiosis Bureau, Johannesburg, South Africa. Disscussioa opened by P. Cartier, Thetford Industrial Clinic, Thetford Mines, Quebec, and I. Webster, Pneumoconiosis Research Unit, Johannesburg, South Africa. ASARCO ELP 0002861 PULMONARY FUNCTION IN AS8ESTOSIS PANEL DISCUSSION MODERATOR: G. L. Leathart, University of Newcastle, Newcastle, England. "Pulmonary Function in Asbestosis: Serial Tests in Long Term Prospective Study" -- M. Bader, R. Bader and A. Tierstein, The Mount Sinai Hospital, New York, N. Y. "Routine Lung Function Studies of 830 Employees in an As bestos Processing Factory" -- R. Hunt, (Asbestosis Research Council), British Belting and Asbestos, Ltd., Yorkshire, Eng land. "The Discriminant Value of Pulmonary Function Tests in As bestosis" -- M. L, Thomson, W. J. Smither, Anne-Marie Pelzer and M. Hills, London School of Hygiene and Tropical Medicine, University of London, London, and The Cape Asbestos Com pany, Barking, Essex, England. Discussion opened by J. L. Whittenb'erger, School of Public Health, Harvard University Boston, Mass. 12:30 P.M. Luncheon Session Chairman: W. C. Cooper School of Public Health, University of California Berkeley, Calif. ASBESTOS AND NEOPLASIA: EXPERIMENTAL Session Cochairman: Katherine R. Boucot Woman's Medical College of Pennsylvania Philadelphia, Pa. 2:00 P.M. ``Studies of Carcinogenesis of Asbestos Fibers and Their Natural Oils" -- J. S. Harington and F. J. C. Roe, Chester Beatty Research Institute, Royal Cancer Hospital, London, England. "Preparation of Asbestos Fibers for Experimental Use" -- M. S. 3adollet,Health Research Institute,Fairleigh Dickinson University, Madison, N. J., and W. A. Gantt, Occupational Health Program, N. J. State Department of Health, Trenton, N. J. "Tests for Carcinogenicity of Asbestos" -- W. E. Smith and Llonas Miller, Health Research Institute, Fairleigh Dickinson University> Madison, N. J. "Tests for Effect of Asbestos on Benzo (a) Pyrene Carcinogenesis in the Respiratory Tr: leigh Dickinson Univer Discussion ooene-.' search Unit, Glamu ASBESTOS . Sessi The C "Asbestosis and Bror W. D. Buchanan, Minis "Neoplasia Among In Special Reference to II. J. Selikoff, and J. N. Y. "Cohort Analysis of C in a Textile Asbestos Council), Turner Broc: R. S. Doll, M. R. C. "Pulmonary Neoplasi; Jacob, Krankenhaus, K Occupational Health, I "The Relationship of in Belfast" - P. C. Belfast, Northern Irel? "Association of Pulm Northern Italy" University of Tu'. , cupational Diseases, Disscussion opened b; burgh. Pa., and G. W rensic Medicine, Wash 6:00 P.M. Cocktail Hour -- Acac York, N. Y. 7:00 P.M. Informal Subscription Keynote Address ASARCO ELP 0002862 BESTOSIS f rastle, Newcastle, il Tests in Long Term ier and A. Tierstein, t* Employees .in an As(Asbestosis Research Ltd., Yorkshire, Eng- 'unction Tests in Assr, Anne-Marie P.elzer nd Tropical Medicine, Cape Asbestos Com- :ool of Public Health, per f California "'MENTAL ooucot jylvania s and Their Natural ster Beatty Research and. lental Use" -- M. S. ickinson University, Health Program, N. E. Smith and Llonas ickinson University* ene Carcinogenesis in the Respiratory Tract" -- Llonas Miller and W. E. Smith, Fair- ieigh Dickinson University, Madison, N. J. ^ Discussion opened by J. C. Wagner, M.R.C. Pneumoconiosis Re A search Unit, Glamorgan, Wales. "I'y -- , .{/ ASBESTOS AND NEOPLASIA: EPIDEMIOLOGY ! Session Cochainnan: W. J. Smither The Cape Asbestos Company, Ltd. London, England (, "Asbestosis and Bronchial Carcinoma" -- T. A. Lloyd Davies and W. D. Buchanan, Ministry of Labour, London, England. "Neoplasia Among Insulation Workers in the United States with Special Reference to Intra-abdominal Neoplasia" -- E. C. Hammond, I. J. Selikoff, and J. Chnrg, The Mount Sinai Hospital, New York, N. Y. "Cohort Analysis of Changes in Incidence of Bronchial Carcinoma in a Textile Asbestos Factory"-J. F. Knox, (Asbestosis Research Council), Turner Brothers Asbestos Company, Ltd., Rochdale, and R. S. Doll, M. R. C. Statistical Research Unit, London, England. "Pulmonary Neoplasia Among Dresden Asbestos Workers" -- G. Jacob, Krankenhaus, Karl Marx Stadt, and M. Amspach, Institute of Occupational Health, Dresden, G.D.R. "The Relationship of Exposure to Asbestos to Pleural Malignancy in Belfast" -- P. C. Elmes and 0. L. Wade, Queen's University, Belfast, Northern Ireland. "Association of Pulmonary Neoplasms with Asbestos Exposure in Northern Italy" -- E. C. Vigliani, University of Milan, G. Mottura, University of Turin, and P. Maranzana, National Institute of Oc cupational Diseases, Lombardy, Italy. Disscussion opened by T. Mancuso, University of Pittsburgh, Pitts burgh, Pa., and G. W, H. Scheoers, Institute of Industrial and Fo rensic Medicine, Washington, D. C. 6:00 P.M. - Cocktail Hour -- Academy Building, 2 East Sixty-third Street, New York, N. Y. 7:00 P.M. - Informal Subscription Dinner -- Academy Building Keynote Address: J. C. Gilson, Medical Research Council, Pneumoconiosis Research Unit, Glamorgan, Wales. ; j ] j ASARCO ELP 0002863 WEDNESDAY, OCTOBER 21. 1964 Session Chatman: H. L. Stewart .National Cancer Institute, Bethesda, Md. 9:00 A.M. "Epidemiology of Diffuse Mesothelial Tumors: Evidence of an As sociation from Studies in South Africa and the United Kingdom" -- J. C. Wagner, M.R.C. Pneumoconiosis Research Unit, Glamorgan, Wales. "Epidemiological Studies of Patients with Mesothelial Tumors in the London Area" -- Muriel L. Newhouse, School of Hygiene and Tropical Medicine, University of London, London, England. DIFFUSE MESOTHELIAL TUMORS PANEL DISCUSSION MODERATOR: W. U. Gardner, Yale University School of Medicine, New Haven, Conn. "Criteria for Diagnosis of Diffuse Mesothelial Tumors" -- W. T. E. McCaughey, Queen's University, Belfast, Northern Ireland. "Histological Chacteristics of Mesothelioma Associated with Asbestos" -- J. Churg, The Mount Sinai Hospital, New York, N. Y., S. Moolten, Middlesex General Hospital, New Brunswick, N. J., and S. Rosen, Armed Forces Institute of Pathology, Wash ington, D. C. "Mesothelial Tumors in South Africa: Pathology and Experi mental Pathology"- I. Webster, Pneumoconiosis Research Uait, Johannesburg, South Africa. "A Biopsy Series of Mesotheliomata and Attempts to Identify Asbestos within Some of the Tumours" -- D. O.'B. Hourihane, London Hospital Medical School, London, England. "Pleural Mesothelial Tumors and Exposure to Asbestos Dust"-- W. Glynn Owen, Broadgreen Hospital, Liverpool, England. Discussion opened by A. Purdy Stout, Columbia University College of Physicians and Surgeons, New York, N. Y. 12:30 P.M. Luncheon Session Chairman: E. C. Vigliani University of Milan, Milan, Italy 2:00 P.M. - PROBLEMS AND PERSPECTIVES "Trends in the Health of the Asbestos Worker" -- K. W. Smith, Johns- Manville Corporation Manville, N. J. "Sequelae of As'o Pneumoconiosis Re "Changing Hazatc M.R.C. Paeumoc' "Multiple Factors i -- E. C. Hammond, The Section c ferences for acti' medicine. This conferee Academy, all phy ical students, as SECTION C Preston L. Perltr. Chairman ASARCO ELP 0002864. I 21. 1964 itewart :he . Md. lors: Evidence of an Asthe United Kingdom" -- earch Unit, Glamorgan, b Mesothelial Tumors in , School of Hygiene and .ondon, England. TUMORS N rsity School of Medicine, jthelial Tumors" -- W. T. Ifast, Northern Ireland, helioma Associated with nai Hospital, New York, lospital. New Brunswick, ;itute of Pathology, Wash- : Pathology and Experioconiosis Research Unit, and `empts to Identify s" . O.'B. Hourihane, on, England. sure to Asbestos Dust" -- Liverpool, England, jmbia University College Y. Ii "Sequelae of Asbestos Dust Exposure" -- J. C. Wagner, M.R.C. Pneumoconiosis Research Unit, Glamorgan, Wales. "Changing Hazards of Asbestos Dust Expsure". - J. C. Gilson, M.R.C. Pneumoconoiosis Research Unit, Glamorgan, Wales. "Multiple Factors in Relation to Neoplasia Among Asbestos Workers" -- E. C. Hammond, The Mount Sinai Hospital, New York, N. Y. PANEL DISCUSSION Moderator: H. Heimann Division of Occupational Health U. S. Public Health Service Washington, D. C. The Section of Biological and Medical Sciences provides con ferences for active workers in the special fields of biology and medicine. This conference may be attended by interested Members of the Academy, all physicians, research scientists, and science and med ical students, as well as those invited to participate. SECTION OF BIOLOGICAL AND MEDICAL SCIENCES Preston L. Perlman Chairman Gabriel G. Nanas Vice-Chairman Vigliani n, Italy iCTIVES cer" -- K. IV, Smith, Johns- ASi 4 ' *' ASARCO ELP 0002865