Document MGZLYmdGagyaegBj3vM2dY3rV

JLe m l Im la a sfr ie AssiM siaticKKft FE L IX EDGAR W O R M S E R ,pr e s id e n t K .C . B R O W N EL L ,v ic e p r e s id e n t *J. A M A R T I N O * V i c e P R E S I D E N T R O B E R T LINOUEY Z IE G F E L D . SEC R ETA R Y -TR EA SU R ER 420 LEXINGTON AVENUE NEW YORK lT.N.Y. MANFRED BOWDITCH D IRECTO R O F HEALTH AND SA FETY A p r il 2 0 , 19h9 ; ' ,jK J- \ '?T t 5,3 ' R obert A. Kehoe, M. D ., D ire c to r K ettering Laboratory of A pplied Physiology U niversity of C incinnati C ollege of M edicine Eden Avenue C in c in n a ti 19, Ohio Dear Bob: Thank you f o r y o u r illu m in a tin g l e t t e r o f A p r il 1$ Your guess as to th e id e n tity o f th e v i s i t o r r e f e r r e d to in mine of March 29 i s q u ite c o r r e c t . Though th e q u e stio n s r a is e d b y him a re now c lo s e d i n s o f a r a s I am co n cern ed , X w ould be amused t o know w hat th e s to r y i s on t h i s man. I s iz e d him up as o f th e "chronic kicker" type. As t o F rank P r in c i and h i s p ro p o s a l, a l l who know him seem q u ite e n t h u s i a s t i c ab o u t th e l a d and my own s in g le a d v e rse c r i t i cism concerns h is d e sire to to s s prophylaxis and treatm ent in to a s in g le b a sk e t, which i s j u s t what he w anted to do a y e ar ago when he was so s u p e r e n th u s ia s tic ab o u t EA.L. S in ce I do n o t f o r a moment c o n s id e r m y s e lf q u a l i f i e d t o pass upon th e more i n t r i c a t e te c h n ic a l a sp e c ts o f anim al ex p e rim e n ta tio n , I have n a t u r a l l y tu rn e d f o r a d v ic e to th o s e who a r e . Here I f i n d two sc h o o ls o f th o u g h t - th e can in e and th e murine - th e form er g re a te r in number b u t th e l a t t e r basing t h e i r c h o ic e on w hat seemed t o me th e im p o rta n t f a c t s t h a t s t r a i n s o f m ice o f known s u s c e p t i b i l i t y t o le a d a re a v a i l a b l e j w hereas, u n t i l Pete L i t t l e has gone a long way f u r th e r , th e average la b dog can be no more th a n a m utt Tilth a g re a t b ig q u e stio n mark on h is c o lla r . KS 0014738 R obert A. ICehoe, M. D. -2 - A p r il 20, 1 9h9 Bo one h ere i s th in k in g i n term s o f "a few hundred d o l l a r s . " I5y s u g g e s tio n o f m ice r a t h e r th a n dogs was i n th e l i g h t o f w hat I have ju s t sa id and so th a t a f a r g re a te r number of anim als c o u ld be u s e d . A c tu a lly , I th in k and have s a id t h a t P r in c i u n d e re s tim a te s th e c o s t o f w hat h e w ants t o d o . And when i t i s decided who, i f anyone, i s to do i t under our au sp ices th e re T rill b e no more thought of tr y in g to d ic ta te e ith e r methods or re p o rts of fin d in g s th an th e re has been i n th e work a t Johns Hopkins and H arvard f o r w hich Tre have fo o te d th e b i l l s . A ll Than I have c o n s u lte d , w ith th e e x c e p tio n o f P in to , who made th e s u g g e stio n , have f e l t t h a t th e work w ith s tro n tiu m w ould be f u t i l e , a n d P in to h im s e lf t o l d me i n D e tr o it t h a t you w ere so m inded, a v ie w p o in t w hich y o u r p r e s e n t comment h a rd ly d i s p e l s . So i f we go ahead w ith t h i s a t a ll,m y hunch i s t h a t we t r i l l a sk t h a t our fu n d s be r e s t r i c t e d t o w ork w ith th e p y ro c a te c h in d is u lf o n a te , a s u b sta n c e /w n ic h , God knows, I know even le s s th an I do about stro n tiu m . Thanks ag ain f o r your always h e lp fu l ad v ice on th e s e and other subjects. Sincerely yours, m b/sd HE 0014739