Document MGNxJ8QwokgR16ja268ydkRa9

Copies to: Material Tested E. I. du Font de Nemours and Company Haskell Laboratory for Toxicology anid Industrial Medicine HASKELL LABORATORY REPORT NO. 125-79 Haakell No. 12,943 ^0-O^thyeigCoedeaa_ Sample Ready For Testing 3/13/79 __Department, Material Submitted ICheaicals, Jackson^Laboratory ORAL LD50 TEST Procedure; The test material, as an aqueous solution, was administered by intragastric intubation young adult ChR-CD male rate in single! doses. The surviving animals were weighed and observed duri period and then sacrificed. The LD50 lvalue was calculated from the mortality data using the method Results: Dose Cng^g) 6,000 Average Body Weight (g) 257 5.000 252 ,000 254 Solution ^L 50 45 40 Average 'Dose (ml) 3.1 2.8 2.6 Mortality Ratio 9/10 4/10 1/10 Clinical Signs Stained face, congestion, hematuria, wet perineal area, oalivation, chrom lethargy, stained body, gaaping, diar moderate weight losu after dosing at Stained face, wet and stained perine ataxia, chronodacryorrhea, diarrhea, moderate weight lose after dooing at Congestion, lethargy, stained face, perineal area, chromodacryorrhea, sa nose and mild weight loaa after dosi Company Sanitized. Does not contain AR226-2879 ft VS^------Rhasvery low toxic ty when administered orally to young adult ChR-CD male rats in LD30 ia 5,543 mg/kgof body weight. HM 6at frequently observed clinical signs at moat levels Included and vet perineal area, lethargy, chrom^daaccrryyoorrrrhheeaa, aalivation, congestion, diarrhea, and henaturia. gaaping w-- obaerved at the 6,000 mg/kR level only. All levels had mild to moderate initial weight I aporadtc loaaea through the 8th day and then followed by normal weight gain. * Coapoaition'.Y^ ** 951 Confidence Limits; Lower: Upper: Slope: 4,535 mg/kg 5,610 mg/kg 14l5 + Finney, D. J., Probit Analysis. 3rd'Ed., 1971, Cambridge University Press. Report by; /[^^ Z. Robert Tec IRLTiscg Report No. 325-79 Date Issued> Approved by: Gerald Chief, Acute In Company Sanitized. Ooes no* contain TSCA CBI