Document MGLpzb16BVV8Qp3qmQ4aGQZ8a

A Division of The Society of The Plastics industry, Inc. May 15, 1997 Dr. Hasmukh Shah Chemical Manufacturers Association 1300 Wilson Blvd. Arlington, VA 22209 Dear Has: Attached is a reference to the 1996 publication on understanding the risk of vinyl chloride, benzene and butadiene. Please advise the thought of the Vinyl Chloride Panel regarding this article, as I know this has been of continued interest to the Panel members. Sincerely, FEB:kc attachment c: R. Burnett J. Kachtick Frank E. Borrelli Technical Director CMA 119026 65 Madison Avenue Morristown, NJ 07960 (201) 898-6699 * Fax # (201) 898-6633 77 OrtQtoai copy of Ota document printed on rcyoW pflpar. and candidates lor rtmire rquaccnoiu. ut paper aiko uvrim u hwui) wuh^uu um ;iuai liiXl, 17,7. t. 77. N |, 1' y, ti,7-(iUe,S. 41 liV'^h UgfSBVBSi 13- 5 .9 7 1 8 :0 7 ; +32 2 S097108 -> HUMAN EXPOSURE - VC. *2 - UNDERESTIMATING RISK FOR THREE IMPORTANT HUMAN CARCINOGENS: VINYL CHLORIDE, BENZENE,AND BUTADIENE UNIV-OF-TEXAS LEGATOR-MS JOURNAL OF CLEAN TECHNOLOGY AND ENVIRONMENTAL SCIENCES Mjwe:EN) 1996 V3.N3.P I99-205.RC& (order 67l!tit) (US) NOT ia CoOcctiaii i *'*- . I A review md rienirtif nib awnl reft. Contrary to frequently expressed aphuona, ita amipAalw ^ tTU^* bgh-dose animal expo. to khv-dosc chronic human exposure may underestimate rather A crrercctiizurte tbb true risk of exposure to carduagons. Bourne, vinyl chloride. awl butadiene are examples where awinmjl ^ extrapolation may sigtafkandy tbc actual rids. Since a vancty of diflemd eagam or nyMMic systems am involved in iMOMtivabcat reactions, which include both pbaac 1 and pfaa9C 2 reaction, any goocr* firniV,lt alteration m either activation or detoxification would have a effect on ** iH cancer. Untied evidence would indicate that propartieeaieiy leas active metabolite is formed at high cqncn. w A, where phase 2 enzymes predominate, while at tower coocns. pathways leading to active metabolites am favored. The overall efhd tiould lead to an nadsmstimnte of risk Cram lugh-doae artinai expti wheu extrapolating to low-Jevd, chronic human exposure. Data with three potent cartinogpns, *-- vinyl & * oAr . -r^ ^irT~ f) f* chloride, and butadiene indicate the possible error in risk eeta. fion anunal cancer bioassay Rudies. This may^f u be a general pattern with cheats, that require enzymic conversion to active metabolites. Tbc public health *4 [ * significance of this underestimation could be considerable and underscore the urgency of reexarag. the jncsebt ride procedures. "New procedures, incfctdim bsooarlren of effect such as chromosome paatieg, DNA repair , d and somatic cell hrutation studies can be applied to monitoring individuals to mw . Known animal carcinogens as delineated by the Interaatiooal Agency for Research an Cancer, where there is a distinct possibility of underestimation of risk based on anoaai studies, should be evaluated by ^ cJfit multiple bionuurker studies hi exposed populations (from CHABA 126-IS674 CA COPYRIGHT 1997 CAS) 13027377740; CMA119027 SODIUM BICARBONATE AND POTASSIUM BICARBONATE: TOLERANCE EXEMPTIONS EPA (order F&7IW7)