Document MG2xMKVM8001Emabzo7152rN9
Survival (%)
8T 403 G
II III GRAPH 1.
Survival of male Sprague-Daulev rats of experiment BT403: groups treated with 20(), 10(*) and 5 mg'Kg b.w. (), and untreated control group (*). -- start of the experiment.
IQO354
Survival (%}
BT 403 Q
II III GRAPH 2.
Survn al of female Sprague'Dawley r?ts of experiment BT403: groups treated svith20(), 10 (*) and 5 mg Kg h.\. (), and untreated control group (-). - start of the experiment.
Weight (g)
BT 403 Cf
I .'I I T I I~~ I I I' T"--*'f* 0 A IS 32 48 64 30 9S 112 128 144 160
I Age (weeks)
II 111 GRAPH 3.
\serage weight of male Sprague-Dawlev ratsof exper iment BT403: groups treated with 20 (), 10(*)and 5 mg Kg b.tv. (), and untreated control group (-). -- start of the experiment.
SL 100356
Weight (g)
BT 403 Q
i ........ i 0 A 16 32
I
i 48
i i 1 1 ~i i 1 r -- t 1
--r*
64 80 96 112 128 144 160
Age (weeks)
II 111 GRAPH 4.
\\erage weight of female Spraguc-Dawlev rats of experiment BT-I03: groups treated with 20 (), 10 (*) and 5 mg Kg b.w. (), and untreated contrul group
(-). -- start of the experiment.
SL 100357
II III TABLE 1
E\pei miem BT103.
E\posurr b\ ingestion (stomach tube) to Vi ns lidene Chloride in oliseotl, at 20, 10, 5 mg Kg b.w,, once daily, -i-5 days weekly, for 52 weeks. Remits after 1-17 necks (end of the experiment).
DISTRIBUTION OF REGRESSIVE CHANCES
A.1DLL14
3200P 1U|
I
II
m
IT
Dtm
20 a*''!*
io nett
3 */! 51 iv ail (CvAtr^l)
9 wtafcs old at tart)
5*1
.to. at tort
0* 50
2
or 04 9
50
100
O' 30
2
<r ud 9
50
100
o* 50
2
0" *od 2
50
100
0* 100
9 o' od 9
100
200
TQtal
too
Livr
Ho, *
22 44.0 19 ja.o 41 41,0
2ft 52.0 20 40.0 4ft 4ft,0
19 3.0 20 40.0 39 39.0 2ft 29.0 3* 39.0 6ft 33-0
*CHK3IY* CHAffCW
Kid37i
unul lud.
Ho. * tit. *
0-0* 0 - 91 a.o 0 - 23 23.0
0 - 1 2.0 0 - 31 52.0 0 - 32 32.0
0-00 - 20 5ft*0
,0 - 2ft 20.0
0 - 3 3.0 0 - 35 55,0 0 - 50 29.0
SL 100358
i
100359
Il/IU TABLE U
l \|n t muni It I llt't:
l.\fHisuir 1j> mgrsiiim (sloni.ii li mix-) u> Vmyliilmr ( liiiiiiili- m olur ml, .11 l!(l, 1(1, fi mg Kg l>.w., muf daily, Todays ivtfkly, Ioi V2 ivc-ckv Heviillv .illn 117 wrrks (riul ill (lie i x|x miiii iii).
DISTRIBUTION OF PHLOGISTIC CHANCES
6I0W 90.
DOS!
I 20 >l/I<
11 10 a*/**
III ) /<( IV (Caalni) fatal
-- UTBUL3
|3yrm lww>y nti 9 ntia U Bt itirt)
biciplul Lc abacaaaaa
3i 0
8
0" o4 8
i o' * 8
o" i o' U4 9 o' ! o' *a4 8
fto.at itwt
50 50
100
50 50
100
50 50
100
100 100 200
9o. * i 6.0
1 2.0
4 4.0 2 4.0 0-
2 2.0
1 2.0
2 4.0 i 3.0 0-
2 2.0 2 1.0
, 500
iMlagiiu
9a. * 4 a.o 2 4.0 4 6.0 2 4.0 0-
2 2.0
4 0.0 i 6.0 7 7.0 1 1.0
2 2.0
5 2.3
firosebapuuaoaU
9a. * 29 50.0 2) 46.0 52 52.0
PHLOGISTIC C1UJICE3
Plaurltla
Panc*r4ltla
Llvar abacaa aaa a4 bap*
titla
*
Mo. * 9a. t a. *
20 40.0 5 10.0 5 10.0
13 26.0 5 10.0 7 14-0
33 33x0 to
10.0 12
12.0
fUa*l abKIMW M0 oapbrltla
0o. *
j 6.0
2 4.0
3 9.0
NritaaltU
9*. * 12 24.0
ft 12.0
10 10.0
22 44.0 9 14.0 i 22 44.0 10 20.0 4 44 44.0 19 19.0 7
6.0 0 0.0 1
7.0 1
-2
2.0 1
1.0 3
4.0 14 2.0 7 j. 21
20.0
14.0
21.0
11
42.0 12 24.0
0
16.0
1
IT J4.0 4 12.0 2
4.0 1
40 46.0 10 10.0 10 10.0 4
2.0 2 6.0 2
4.0 4
4.0 14 4-0 3 4.0 19
2B.0
10.0 19.0
41 41.0 10 iB.O 6
26
26.0 11
11.0
9
*7 .* 14.3 15
6.0 1
9.0 0 7.3 1
1.0 12
- ft
0.5 20
12.0
ft.O
10.0
12
ft
10
12.0
ft.O 7-0
U III TABLE 3
Experiment B'H03:
E\posure b\ ingestion (stomach tube) to
litlenc Chloride in oliu' oil, at
20. 10, 5 mg kg b.w., once tlatlv, 4-3 days weekly, for 52 weeks.
Results after 117 weeks tend of the experiment).
INCIDENCE OF ADENOMATOUS HYPERPLASIA OF RESPIRATORY EPITHELIA
C800P SO.
I
II
:xx
rv Total
aost W at/it 10 tf/It
5 mt/U Oliva oil (Control)
i-rnuLLS
(3pnfg*0aplaf nta, 9 ** oU at atam)
Sal
0*
i 0* u4
Q
So .at tart
50 90
100
0*
l <3* Ul 9
50 50
100
of
4 0* iul j
50 90
100
0- 100
9 CT 4 9
100
?oo
900
lOStOUfOCB fR?KTU3U op RBuusoir epirmu
ffa. *
is 84.0 7 U.O 19 19.0 If 22*0 5 10.0 1< 18.0 8 1S.0 J 4.0
10 10.0
u 14.0 5 9.0 19 9.5
6
U HI TABLE 4
|x i imcm BT103:
Esposur? b\ ingestion (stomach tube) to Vmylidcne Chloride in oliveotl, at 20, 10. 5 mg Kg b.w.. once datlv, 4*3 davs weekly, for 32 weeks. Results after H7 weeks (end of the experiment).
INCIDENCE OF PITUITARY ADENOMATOUS GROWTHS
:bo& NO*
I II :ii ?V
>osi
20 14/Tf
10
5 =*/u Oliv* oil Ciotrol)
A.YOUL1
(5p3-M^-E^i*y fit*.
9 * 14 at itm)
Sax
Ktt t&rt
0* 50
9 0* ud Q
50
100
T
i 0* iad j
50 50 1QO
u*
9 0* mi
50 50
100
0*
2
O'* ind Q
100 100 200
500
50901A1 AUCtaU* rods HTTZarUSIA
Ho, <
0 1 1 0 0 0
0 0 0
J1 <
9
-
2.0
uo
J.O 5*0 4,0
AHC1QU3
*5, i
2 4.0 4 .o C 8.0 2 4.0
1 2.0
i 5.0 1 2.0 7 14.0 8 9.0
1 1*0
J J.O 4 2.0
!OIii
So. *
2 4.0 j 10*0 7 T.O 2 4.0
1 2.0
3 J.O i *.0 7 14,0 s 9,0 4 4.0 8 s.o i* 9,0
SL 1-00361
100362
II HI TABLE 5
111(0.1:
Expu.iurr It) iiigesiutti (mtuiM h mix) in Viiiyliik-tic Lhktiiik- ut olne oil. .u 11(1, (0, It weekly. Ini :VJ weeks. linutli .iliei 117 weeks (end of ike e\|Hi imeni).
' Kg tt.iv., once daily, 4-5 days
DISTRIBUTION OE THE DIFFERENT TYRES OF TUMOURS
(liru pati)
iBDUiS
ABDUU vmt TW0DJ6
GBOOP
(Sprup** ftiwUy rtfc 9 mill o!4 M atirt)
Mmiut tuMura ibt
flood
emuPBU
UuAbmiIm Ktphrobl
io o*rco*o*
Liv*r
Otkor oltoo
lapPQM aal
Lmr
Otbor Bit**
CO tr*
BO. MSI
fc*re|v
Avar|t
ivor*f
Av*r*f
Avontf*
Avontf*
Avonfo
Avor*fo
s
lo.at tort
Cornet d AlOH> br (a)
To~ t*l Bo.
* (c)
lAtanc? T*11M tu i**.i) Bo.
5 (c)
Lotoaejr TotIM t*l (*) Bo.
51 U)
BtUCJf Totwo t*l
o*ko) Bo.
5 (4)
lotOQCJ tua
(*>
fOta) Bo.
8
(c)
lotoaejr Totii U1 (ooko) Bo.
9 (4)
Utnej
IIM (ork*)
ToU1 Bo.
* (.)
l*t mey
Um (Mka)
Tot*l Bo,
* ()
lotOBCJ two
Li*I-
...til.
<>-
_iii_
(*i
111
cr so 49 2 4*1 92.0 0 -
2 4.1 99*5 0 -
0-
0-
0-
0-
2 20 as/It
50
0* ind ^ 100
46 2) 47.9 71*5 0 97 25 25.6 7J.S 0 -
- 0-
- 0-
- 2 2,1 99.5 0 -
- 0-
- 0-
- 0- 0*
- 0 - - 0-
- 0- - 0-
-
-
cr so
11 to uc/ka
9
so
OTwid f 100
4fi 2 4.2 114*0 2 4.2 77.0 1 2.1 1)1.0 0 -
50 24 4b.0 36.2 0 -
- 1 2.0 105.0 0 -
91 26*5 83*3 2 2.0 77.0 2 2.0 118.0 0 -
- 0- 0-
- 0-
- 0- 0
- 0*
- 0 - - 1 2.1 13)*0
-
0-
-
0-
-
-
0"
-
1 1.0 m.o
or w
in 5 fJU
9
50
iTtnl 9 100
49 i 6*1 90.0 0 50 28 56*0 89.5 0 * 99 )1 Jl.) 85.9 0 -
- j 6*1 , 92*0 0 - l 2*0 37.0 0 - 4 4.0 90.7 0 -
- 0- 0- 0-
- 0* - 0 - 0*
- 0- - o-
- 0- - 0-
-0
- 0-
-
-
or 100 100 10 10*0 114*6 2 2.0 1)2.0 9 9.0 78.J 0 -
IV
OllM oil (Cootrel)
S
100
99 51 57.0 Bj.a 0 -
- 2 2.0 84.5 0 -
arnd 9 200 199 47 JJ.7 36.4 2 1.0 1)2*0 11 5*6 79.4 0 -
- 0-
- 1 1.0 54.0 0
- 0-
- 1 1.0 119*0 e -
- 0- - 0-
- 1 0.5 119.0 i 0.5 54.0 0 - - 0 -
-
totl
yoo 49)
(.0 Alive .timii.il-> .11 11 weeks, when llu Inst miuttiu (a uuimiury atletint .n< iiuiiun) was ultsrtml. (Ii) Twin............ tut.......is til die sniiu- ami ililletein iy|u-s (lilmj.uliimm.is. tan tittimas, sattiuiias, tan iuiis.ni minis) may Ik- .................. die same animal.
(t) Flu- |M'ii ellinti's .ne ICtrliis I tu tlte i tuns led nuinliri. (ill Aver.iKt- ay-e at dir iMisei <>t I In- lai si tn.imm.iiy tuniimi |ier annual iletei list ai die |M-tit>dit t-K.mim.imiu tu at auittjisy. (li Average im limn lilt- statt ill tin- rv|triiiui-Mi tu the ikuttimi (at the |kiu*Iii cKaiiim.ilinn tu al aiiin|isy).
(f( Vvet.'tl .tiinn.ils mill twit in nuMc iiinimits
I
O t>
11/111 TABLE 5
1 h i inn hi III -MW: i i/immc liy uii'i .iui m (siom.n ti IuIh ) u> Vinylidem- ( Idol iiic in id nr ml, ,l| i'll, 10, 5 ivccMy. tin /!' ur< kv liemtli .iltn 117 yvciks (end of llu- cs|ici imi'in}.
K|> It w , once daily, 4 5 days
DISTRIBUTION OF THE DIFFERENT TYRES OF TUMOURS
AN DULLS JTH TUfOUJB
csoar o.
DOSE
kltpota
PonttHacb tpi thtUtl tuatbur*
Subcut *nou* treoBM
c*phaJ ic tusour* B*ureblIoat* (Rltr tvpca
lvr*|
Avr*f*
Average
Avtrtft
lAvr*{t
to* tBl *.
T (c)
Utoncy totut tal
(n.kal Mo.
UUM| Totill tal (Otfco) M*.
UUDtjr Totut bo.
lttwc; Totuu tal
a
1blooey tut
(-Us) Kb. rok*)
Total Mo.
<
Total
Mb.
(!) (.1
Hi
--Lsi--
<>
0-
0-
- 0-
- 1 2.0 102.0 0 - -
0-
7
1 30 c/t| 0 0-
- 2 4.2 95.5 0 - 2 2.1 95.5 0 -
- 0-
- 0- -
- 1 1.0 102.0 0 - -
00-
1 1C
0-
- 0-
- 0-
- 2 4.2 111.5 C - -
1 2.1 e
11 10 B(/4 1 2.0 120.0 1 2.0 7.0 0 1 1.0 120.0 1 1.0 ?.o 0 -
- 0-
- 0- -
- 2 2.0 111.5 0 - -
0-
1 1.0 14
0-
- 0-
- 0-
- 0-
-
0-
-
2 4.1 4
111 5
0-
0-
- 0- 0-
- 0- 0-
- 2 4.0 75.0 0 - - 2 2.0 75.0 0 - -
1 2.0 4 J 1.0 t
IV Ollv Oil
0.
- 1 1.0 100.0 0
1 1.0 124.0 4 4.0 105.0 0
1 0.5 124.0 5 2.5 104.0 0
-
-
- 2 2.0 100.0 0 - -
- 0-
-
0-
-
- 2 1.0 100.0 0 - -
2 2.0 11 1 1.0 1} 5 2.5 24
lottl
(second pan)
Otb*r*
laltQ
fe*
aat Ha la.
Total ifi
Mo.of Miff*-
<
ml tiaoiirt, twnr Mar-
Uf --laola
t
1
9 18.4
1.1
1 2 25 52.1 1.1 7 1 14 15.0 1.2
i
1
9 18.7
1.5
1 1 28 5S.0 1.2 e t 17 n.7 1*4
2 2 11 22.4 1.1
2 2 u 64.0 1.2 4 4 ti 41.4 1.2
1C 1 39 29.0 l-J
6 5 M t).t 1-1
If
92 46.2
i.i
tO O 't
(a) Aim animals .11 II wicks, wlirii list- (11st iiiimiiir (a inaimnaiy atlrnm aninoina) was tdtsciveil. ((,) | m nhiii- iiinimus nl llu- same .uni ur ildfrtrui iy|>e fliluoaitciiiHius, carcinomas, sarcomas, 4 an 11111s.1nm11.1s) may lie pit-sent in the same animal.
(c) llu | hi1 riuatycs air iclcncd 10 I lie immiiil iiinnlH-r. (tly Ait-fagr ori- at tlw tmsr-l id llu- Iiim muininaiy I inmull |srr animal ilctctirtl al llu- |irr iodic exam ilia lion 01 .11 ,itiiii|isy. (e) Antaiii- Him limn die tlaii id tin- rsjictmuiii in die dcimimi (al llu- | (cumin exam ilia lion 01 at autopsy).
(I| Sr111.1l ...............Is null Iwn ill mull- I in limns.
1
ll llf TABLE 6
l1 \ | M'i t h U'tii It JUM:
/upmuie fry m^fsiion (siouutfr itibr) lo YiiiyUdrmT.hJouJe m trim* oil, aj 1*0, 10. f> weekly, hu f>2 weeks. Jfrwnfrv aJici 117 weeks (end t4 ihe esjieMmeiH)-
hw.r once daily, 4-5 days
INCIDENCE OF THE DIFFERENT TYPES OF TUMOURS REFERRED TO SPECIFIC CORRECTED NUMBERS
(first |*irl)
CROUP o.
1 11 m TV foUl
20
10 >/E|
5 hA
01 iv* oil ( Cootroll
SH HEALS (Spri/ut-bMl*/ rot* 9 ***** old *t itirt
tuaour*
lyabtl gl*o4 CftKUOUl
L*uk*t*
Soft
o* S O* end f ct
t cf oai 9
Ho.ftt otort
50 50 100
50 v>
too
Cornet *4 au*> a.
Mr ()
Corr*cj * 4 DUO* Ho.
Ur (b)
49 2 4.1 JO 0
*e 47*9 14 0
97 25 K.B 64 o
40 2 4.2 J4 2
50 24 46.0 35 0
90 26 26*5 69 2
Correct * 4 su- H*.
*r (c) - 4 2 - 4* 0 - 96 2
J.S 46 1
- 50 1 2.9 96 2
6
4*2 2.1 2.1 2.0 2.0
or
9 CT od 9
50 50
too
49 1 6.1 10 0 50 26 56.0 44 0 99 11 ji.j 74 0 -
49 j 6.1 50 1 2.0 99 4 4.0
tr 100 100 to 10.0 74 2 2.7 99 9 9.0
100 99 57 57*6 62 0 - 96 2 2.0 CT on* ^ 200 199 67 11.7 156 2 1*1 197 11 5*6
*00 491 iti 490
All DIALS WITH TUCOCJES
hm phnUlut
An*i o arcooaa
Lis *r
Chncr *itft
tartouf oo4 ntraufiMaa
Livtr
Otbar alto*
Corr*c
Correct
*4 at*ft-~ Ho. * 4 ntw Ha.
ber b*r (4)
Cerrec
Correct
Correct
* 4
Ho. *
bar (ol
br
Jto. * Mr"(7i -
- 0- 1 0-
32 0 -
- 0-
30
- 0- 2 0-
34 0 -
- 0-
20
*
-
-
- 0- 5 0-
66 0 -
- 0-
5 0-
- 0- 6 0- 0- 7 0- 0- n 0-
37 0 16 0 75 0 -
- 0-
4 1 16.7
* 0-
7 0-
- 0 - 1) 1 7.7
- 0- 2 0-
16 0 -
- 0-
2 0-
- 0- 4 0-
46 0 -
- 0-
4 0-
- 0- 6 0-
66 o -
- 0-
6 0-
* 0 - 17 0 -
63 1 1.2 -
0-
17 0 -
- 0 - 7 1 14. 1 6E 0 -
- 0-
7 0"
- 0 - 24 1 4.2 171 1 0.6 - 0 - 24 0 "
- 46
J9 -
*e
(a) Alive a mauls ji 11 u-trks, when tlu- Ijim iiMimiuiy tumour was <dscivnl. (bf Alive .(ittitMls ,i I/J itnii, wlieu the fiisi /ymlxil f*kuid carcinoma was observed, (O Alive jimn.th .it ll Hnii, wlwa ilir liisi icuk.mnia was olwrvetl. (tl) Alite aiiiin.iK at 110 weeks, wiit'ii llu- lim mifjovirumlii was obseivetl. (ej AU\t animals at M wirks, wlrrit llir an.du'|Mlit .nif(ioiiiH(Hiu was obseivetl. (f) Aiitv animals at Mi> weeks, nltnt ilie aii<iljt'|uiM angioma was tilAt'iuil
t
ll/lll TABLE ft
I\|hi inicm ItllO.l:
Ev/imurr liy ingestion (siomat ti Inlie) in Viuylidene (-liloi ide inoliveoil,.i[ 20. II), ft mg'Kg U.w.oncedaily, I-ft days weekly. lor 52 weeks. Hrsuht .illei M7 weeks (end ol die exjx'iiiiiem).
INCIDENCE OF THE DIFFERENT TYPES OF TUMOURS REFERRED TO SPECIFIC CORRECTED NUMBERS
CBDW no.
MSB
I 20 ac/Ef
II 10 R|/l|
III 5 nAi
IV
01m oil (Control 1
Total
lUpBtMU
Porutoucb ipi Uflltl twrnn
Correct*4
0omct4
Aiabir Hft. X
auaUr Bo.
U! Od
) 0 - 27 0
2 0 - il 2
5 0 - 5* 2
6 0 - jj 0
6
1 U.7
n
1
12
1 8.1
66
1
x
6.4 3-4 J.O
2 0 - 27 0 4 0 - 44 0 6 0 - 71 0 -
17 0 - 67 1 1.5
7
1 U.J
77
4 5.2
24
1 4,2 144
5 i.s
41 )H
jjiquu rm tmouaa
Skin Btituwu
Corrected au*b*r Bo. X
- 0- 0- 0- 0- 0- 0- 0- 0- 0- 0- 0- 0-
SubCUt00*011* utoaw
Corr*ct*d
DiaUr Bo. U)
X
12 1 3.1 34 0 46 1 1.3
ia 2
41 0 79 2 2.5
40 0 -
4ft 2 4.2
ae 2 2.)
ai 2 2.4 m 0" 172 7 1.2
- 405
I (second pari)
liKllirtw
Correct*4 author So.
X
- 0- 0- 0- 0- 0- 0- 0- 0- 0- 0- 0- 0-
-
0365
IK) .Vine animals .11 120 weeks, wlleii lilt- [nsl l>e| lamina h-.is ntiserveil. (It) Alice animals ,M 07 weeks, wlien I lie tnsl fiut-sltimaiil epillieli.il ItniiiHil was olisersed. (i| Aim- animals at 52 weeks, w hen llie 111 si suIm ulaitetlus sauian.i was oltseived.
rolic
I
IZ/UI TABLE 7
Experiment BT403: Exposure by ingestion (stomach tube) to Vinylidene Chloride in olive oil, at 20, 10, 5 mg- Kg b.w., once daily, 4-5 days weekly, for 52 weeks. Results after 147 weeks (end of the experiment).
DISTRIBUTION OF THE DIFFERENT TYPES OF MISCELLANEOUS ("OTHERS") TUMOURS
3X no*
axuuls assame arwai tvmin
Srtl0l Distribution of hlitotrpoo
Ho. Distribution of Motetypo*
O-
t ?
1 tklA acuitbooi } dratofibroa * i lolot call odi*a 1 adronal fluid cortical adonoaa 2 phooebroaocytoua*
i 1 phooehrosocytoa*
1 intootlnal adonoc arc 1no** 1
2
1 Ballonuit fruntlo** coll taaour 1 mdonocareiAoa* of tbo utofti*
<f U
?
J danutofibrcoao 5 1 tubcutuioouo fibrosa
1 phaoahroaoeptoM
J adrui al flard cortical aduioffiao 3
1 Strad flbniiRtit 3 t lun* ftricrttMrcaaa
1 pltural nntbiUMi
1 admocarcifton* of tho utoruo j 1 flbro*Arcou* of tho utoru*
i porleytourcoaa
f 3 2 daruatoflbrono
1 eholanfloua l 2 1 adranai. fluid cortical aduion*
1 Ida itbisiMi idanou
2 limtofltmu 1 4bcu tmaouo iipoaa 0* 10 1 aoosary Upom l lolot coll adtnoaa 3 phooeArouocyta* t Uydlf coll tuaour
1 oubeutuioouo Upon*
1 Jyabai fluid acuithou*
s
6 1 puIvonary adnan 2 *drufial flond cortical adonoaa*
2 phsochroeocyto***
t loioiQroa* of tno utorua
2
1 firlejtoMnMa of tho thyuo* i port tonoal aoootholiout
1 adronal fluid eortloal adut*car* 2 clnoi*
1 odonocareiAo** of tho>.utoni#
1 ctrclntaa Ln tAyna
1
clnoa* 3 i oy^athotld phooarouohla*t*u*
1 anlifpant fruiulo** coll tuutvr
2 aduiocarctnoaoa of tho aioruo
7 3 t 4 4
tl
M
iOO^6 sv
II/lll TABLES
I- \|mmn'ul It 110.1:
E.v/miwih' Its uiKiMioii (miiiii.u It lulu-) to Viiiyiuli'iif (litonjf m nine oil, .11 2(1. 10. ft tut; lmkly, Ini :'i- uvrk v
.illti 117 tvi'iks (cml of tltc < K| k'i 111 lent)
DISTRIBUTION OF THE DIFFERENT TYPES OF MAMMARY TUMOURS
b.w., once daily, 4-5 day*
SL 100367
CHOOP 10.
D05I
jUIDUlU
"pr*<ut^BBUjr rata. 9 lkl sU at BtBlt)
ivrt(a 60. of
To
Utiacji tuaoura/
tal tUw
Correct to. (el (itba) Ubtioi
Si
Ho.tt 4d BW tart
(4) bbImIb
tr (!
To tal 60.
< i>)
0?
I 20 */**
S
O* ud Q
c*
II 10 aft/Kf
s
or* and 9
0"
III 5 ag/ta
9
0* U4 )
a*
Oil** Oil
IV (Cuitroil
i
cr* u4 )
Total
50 50 100* 50 50
100
50 50
100 100 100 200
500
49 46 97 4b 50 ?e
49 50 99
100
99 *99
49J
2 4.1 2) 47.9 25 25.6 2 4.2 24 4b.0 26 *.5
1 6.1 26 56*0 51 11.) 10 10.0 57 57.6 7 11.7
92.0 71.9 71.9 114.0 et.i
66.1 90.0 89.b
114. t).
aa.4
1.0
1.)
1.) 1.0 1.4 1.1
1.0
1.5 1.5
1.1 1.1
I.J
2 100.0
22 95.* 24 96.0
2 100.0
24 100.0 26 100.0
1 100.0 26 100.0
H 100.0
*0 100.0
57 100.0 67 100.0
MAMUar TIMOOKJ lb)
iiMUtid
Hlotetypa
flbroaiA u4
t ibroadaaoaaa
StnoM
Avar14a
UlMCf
latancj
UtMtf
Ho. * tlM Ho. * tiM Ho. * tlM
(o (ko)
to {aaka)
((>
Ha.
*
(D
to)
2 100.0 92.0
0-
w
0-
H) O-
17 If.) 75.6 7 ii.a 72.4 0 -
- 0-
IS 79.2 77.1 7 29*2 72.4 0 -
- 0"
2 100.0 114.0
20 85.) 91.1 22 64.6 95.0
0T a.2
7 26.9
71.1 71.1
000-
- 0- 0- 0-
2 66.7 101-0 1 11. J 64-0 0 -
-
26 92.6 60.9 1 10.7 107.0 % ).* m.o
26 90.1 .s 4 12*9 96.2 1 1.2 1)7.0
000-
10 100.0
1 10.0 m.o
42 71.7 05.7 16 26.1 01.A
52 77.6 91.4 17 25.4 e.6
0-
1 I.T
1 1.5
-
10).0 10).0
01 1.7
1 1.5
lvar*c"
UMm)
tlaa (MU)
ti1
-
~
-
59-0 51.0
(a) AltIf inim.il' .11 II vnvks. tvlii-11 tlu- Iml mint mi (.1 mammal) .iih-nta.iii ultima) was olisritnl. (It) I tin tn Hum intiuiiiis 11I the viiiit'.....I <11 ilillfti'tii iy|u-i (lilimaili'ntmias. 1 an iiumuis. saninuas, i.m iiinsauouias) may lie |iii-vt-in in i)ie same animal.
(i | I lu- |riirin.i|tii .nr u'Ifuni in Ilu- 1 in 111 nil number. (il) Aui.iki ,ij>i* .11 llie until nl iIh* Inti nummary iiiinmii |*r annual ililntfii ai lltf ttidii i-xaininalion (11 ai iit<>|ny
(e) Tlir (n il fiitatii's aif 1 i'Iihnl 111 1m.1l mimliri nl animals l.'aluiK mamnuiy InnIIIUI1 (J) Ilu- jailI'III.IKI'1 ail' Ifhniil In liaal iminlai ul animals la-41III# iiiaiiunary Iiiiihmii 1. liisinliiKHally esannil.
Ill/TABLE 9
Experiment BT103:
E\posure by ingestion (stomach tube) to Vinylidene Chloride in oliseoil, at 20, 10, 5 mg Kg b.w., once daily, -1-5 davs weekly, for 52 weeks. Results after H7 weeks (end of the experiment).
INCIDENCE OF MALIGNANT MAMMARY TUMOURS (CARCINOMAS, SARCOMAS AND CARCINOSARCOMAS) REFERRED TO SPECIFIC CORRECTED NUMBER
shoo* no.
I
*
4*
III rr ?ati
XBS
10 i^t|
5 *t/tt
(?satrol)
UDUU
(Spracu^oteU? r*tt
9
at atart)
* no,M
tort
0* 4 0* and f
0* 4 0* aad or
9
0* at f
0* 4 r ao4 q
50 50
100
50
50 100
50 50
100
100 100 200
500
0orr*ct*4 abr (4)
9 46 n
46
50
90
*9
50
99
100
99 '99
491
tiuciuflT nnon rxaas
* Ho. <b) tia*
(**)
0-
-
7 19*0 73.4
7
7*8
73.4
0-
-
7 14*0 73.1
7 7.1 73.1
2.0 44.0
4 8.0 114.1 5 5.0 104.8 1 1*0 1)1.0 18 18.3 8J.5 >9 9.5 88.0
8*. at tianri/ tiww t.uia. uUlll
-
1.1 1.1
1.0
1.0
no
no
1*0
no no no
i.ii Mm- animals at 11 utrks. when the first malignant mammals tumour was oliserted. I)i Hie |*r< outages are rt ferret) to the corrected number.
100368 Sb
II/HI TABLE 10
Experiment BT103:
Exposure b\ ingestion (stomach tithe) to Vin\ lidene Chloride in olive oil, at 20. 10. 3 ing Kg b.w., once daily. ^-5 days weekly, for 52 weeks. Results after H7 weeks (end of the ex|rerimenO,
LOCALIZATION OF EXTRAHEPATIC ANGIOSARCOMAS ACCORDING TO SITE
csoor TO* I
II
III
rv
m V* i 0* 2 v % <f %
TO* 0 0 0 0 0 0 1 0`
ETTbuiSFUtc uwatucaus 1 kldsty -
II III TABLE 11
E\porimrni B T-103:
Exposure bv ingestion (stom.ich mbe) to Vim hdene Chloride in olite oil. 20, 10. 5 mg Kg b it.. once d.iily. -1-3 tints weekly, for 32 Meeks. Remits .ifier U7 weeks (end of the experiment).
LOCALIZATION OF EXTRA HEPATIC ANGIOMAS AND FIBROANGIOMAS ACCORDING TO SITE
SBOOF NO. Z a III IV
3Z1 O'* 2 7* 2 0* l T -?
NO* 0 0 1 0 0 0
0 0
st:?jlhz?xt:c mezaua jure ru*o*niaua
-
-
i ott
flbr*Mioa*
-
-
-
SL 100370
II III TABLE 12
Fajhm imt'nt BT103:
F.\posurr bt ingestion (stomach tube) to Viny lidene Chloride in olive oil, at 20,
10, 3
Kg b.w,, once daily, 4-5 days weekly, for 32 weeks.
Results after 117 weeks tend of the experiment).
INCIDENCE OF H3 PERPLA5IA <++, -H-^) AND D3 SPLASIA (++/, -H-t-/) OF ANGIOBLASTIC CELLS LINING HEPATIC SINUSOIDS
C2O0? NO.
XJSM
1 20 h/C| 11 to *g/Xf
111 5 if/tf
IT
3li*t oil (Csntr.3.)
?9tU
A53AL3 fSnra$u^0a*l4/ rutt, 9 old it ivu-c)
3X
0*
i 0" tad 2
T 2 0* od 2
0* ! tf* tad 2
0*
i 3* sad 2
No.at tain
50 50 100 50 50 100
50 50 100
100 100
200
500
PtOLireXAIIOR or HZTUIC CZLH
Olfftatd ij-prpla*ia
Nodular fejpoivlaaia
Ntdplaatll aoduld
K.
* No i
t No.
*
1 2*0 0 a 1*0 2 9 9.0 2 0-2 9 io.o 4 9 9.0 4
3 5*0 t 9 <8.0 2 tj 17.0 i
5 5,0 2 10 10.0 0
i5 ?-5 7
-0 4.0 2 2.0 2 4*0 0 i.o 0 4*0 0
2.0 0 4*0 0 3.0 0
2.0 0 -0 1*0 0
4,0 2.0 *
"
* -
1003'7^SL
II III TABLE 13
a|hm mu-in BT103
E\posmf bi ingestion (stonuih tube) to Vim hdetie Chlot tile in olive oil. nt 20,
.10 5 mg K.g b.w,. onre d;ul\. -1-3 d.iss weekh. for 32 \seoks.
Rrmlts .ifter I IT ueeks (end of the cNjieriincni).
INCIDENCE OF DIFFUSED HYPERPLASIA, NODULAR HYPERPLASIA AND NEOPLASTIC NODULES OF LIVER PARENCHYMA
croo?
Don
i jo i/n
tO 34/I4
in 5 34/u
:y
CX;y# oil Control)
!?!
oaxLS
r*ta, 5 old at tun)
Ux
0*
* O' &nd 9
5a. at itin
50 50
too
J" ? o* wd 2 cr
<f and 2 a* i
0" tad 2
50 J0
100
50 50 100
100
100 200
500
prolitoaiic* or aucicilactic crus or waxic shubocs
++
------------*++*
5a. *
* 5a* <
0-
O
1 2.0 0
1 1.0 0
000-
0-
0
3 6.0 0
3 1.0 0
000-
000-
t 1.0 01 0.5
0 0 0
0 0 0
000-
000-
SL
II III TABLE U
peri mem BT103,
Exposure bv ingestion (stomach tube) to Vinylidene Chloride in olive oil. at 20, 10. 3 mg Kg b.iv., once daily, 4-3 davs weekly, for 32 weeks. Results after 147 weeks (end of the c\|*'rimem).
DISTRIBUTION OF FORESTOMACH EPITHELIAL TUMOURS ACCORDING TO HISTOTYPE
caocp 30,
DO3
i ?0
n 10 trs/Tf
m 5 t/U
Oily* il rv (Control)
Tfltil |
AJT3U13 (3prt$ua-D*l*7 rtt. 9 ** o!4 at atart)
S*x
30,At Co met#4 tart nnbir < a)
<r 50 49
i 50 48 100 97
i rf tn4 ?
9 0* and 9
50 50 100 50 50 100
48 50 9 49 50 w
0*
9 *&d 9
100 100
?00
100 99 199
500
wsestouch ditkeliai. raone
pantiles** ttA icaatP.cna*
OarciaoM*
Jo. Jo.
00 i0 70
00 !0 10 00 00 00
t0 3t 41
,ii Vine .imnuk at II weeks, when ilie fust tumour 'a uiuuiuuiy adeiioruriinnuui was observed.
SL 100373
IL III TABLE 16
E\|X'i mu iu B T103:
E\pr>Mtrf hi mgesnon (stom.it h mbc) 10 Vim lidene Chloride in oliieoil. .n 20, 10, 3 mg Kg b.w., once d.iih, -t-3 d.iis neeklv, for 32 necks. Kciuf/.s .ificr 117 weeks (end of die e^xTiment).
DISTRIBUTION OF ENCEPHALIC TUMOURS (OTHER THAN NEUROBLASTOMAS) ACCORDING TO HISTOTYPE
"DOOT XttI I 10 %i/X4 II 10 Z4/X.4 III 5 ^ Olttf oil rv (Control)
,_
9 #aka old at atart)
:*
J0,4t Corraetad tart nxabtr (a)
cr* 50
49
9 50 1* 4 { 100
40 9?
0* 50
40
? 50 0* and too
50 30
j*
9 O'* and ^
50 50 100
9 50 99
0* 100
TOO
9 100 O' aad 9 TOO
99 199
Toil!
500 03
Ipcndydoa**
5o, 0 0 0
0 0 0 1 0 1
0 0 0
ZflCEHU&XC 7VOOB3
SaaiafioBdd
01 kicliooddvdfid&ro-
*4. Jfo,
00
00 00
01 00 01
10 10 i0
I1
30 4!
.11 Mur .iinm.il>. .ii I -t neeks. n lien the firsi fumimr a ni.minun ,nlenoi.imnom:ii ius obsciu-d.
si 10374
tl III TABLE 17
F.,\|x.i imcm B f 403. Exfxjswrbs mgcMinn (siointidt mbcno \'in\lidcnf Chloride in olive oil,.it 10, 5 mg b.w., oiue d.ul>. i-i da\s weekly, for 52 weeks. Results after 1 17 weeks (end of the e\|X'iiment).
incidence of total malignant tumol rs
shoot
*0
I
II
m
IV
zazt
so bcAc
10 m/*4
5 Olivt oil (Control)
(3pr*fu*-0inil*jr rtt* 9 #k old ot itiriJ
3*f
1*0,t tun
r 50
9 o* nd 9
0*
50 ioo 50
___ ____i,..O' ad
50 100
0 0* tad 9
0*
9 cr Bd 9
50 50 100
100 100 ?00
5oe
1
Mi Hu- ii'Ki'iii.nti'S ,ne rvliind io the number ,u Mart.
vnu. maigwt tvoob
Hd* * (> 4 8.0 9 18,0 U 1J*C 9 18.0 i) tt,Q n JJ*C
& 16.0 10 30.0 ie 1L0 ie 18.0 31 Ji.C 4* 24.5
SL 100375