Document MBqybwKbQxoYzopK1eQ6JvDk

D. L. Serndon ifarshall Laboratory Fabrics and Finishes Oefwriaaeni Philadelphia, Pa, January 7, 1955 HOOB8 PAUKS gCggAmrSS PgggtL KgRCimr OLSAfE Following the visit to liasball Laboratory by Mr. Stuart Graves and yourself, ve have discussal the prcfelm presented by the inclusion of phenyl mercury olaate in house -paints and hays the following proposal* to present for a study of the hazards involved in the use of this material. Ve recommend test ins the fuiiowiue four products;: 1. Polyvinyl acetate house paint F-lOQ-8-23523 2. The above product with the phenyl mercury cleats emitted 3. A typical oll-baae house paint containing 0.2 per cent phenyl mercury oleate h. The product (3) with the phenyl mercury oleate omitted, Vc should luce to test tfsese four paint products for acute tendcity by oral adnialstratlcn to rats. This would give us a rapid tost in which it is possible that significant differences night shew up and ehieh would give us a toxicity range art which to base the rest of ths program. Wo should then libs to test the four paints on rabbits using skin application with repeated daily exposures. Ths amount of chemical to be applied at each exposure would be ah approximation of the amount ehieh it night be reasonable to asst,see could be easily spilled on tbs bawd* of a painter. A adairaea of four animals per test cbiwricml would be required. The absorption and aceueulatloiT'S" mercury in the livers and kidneys of teet animals would be determined. Half the anlaals would receive five applications (one per day) and then be sacrificed, whereas the other half of the anlaals would receive ten applications before sacrifice. Determination cf the mercurial levels in ths livers and kidneys would enable us to obtain a picture of ths build-up of mercury levels in the organs on reposted application. D. L. Haradoa Jbsuary 1, 2955 Shs above teste would be carried out using wat troth paint, Ha feel it also advisable to detaraiae the possible prlaary Irritation sad eanaittnetioa -properties of the dried paint film. IDs greposa to do this by applying paint to an ordinary' "Band-Aid" bandage, allowiiag tba paint to dry to a film and then applying the hanrtsgs to the akin of jlrwawi volunteers. A pilot test oostld be carried out using about ten volunteers frcai our cam laboratory, fhis would enable us to dstersdns idntber car not a aavara reaetioa results so that m could later do a larger scale tart- employing . SCO volunteers. Kt feel that the larger nuSbsr la advisable to dbtain a significant result* we aetluata that the cost of tbs work outlinsd shown will be about $6,900.. She following table will egplain the way in which Ibis total oast figure has been obtains** Cent par Costa for CcnDOtaat h Ccnsmtids igproxlsmte lethal dose (oral) with mts 5 5 $ 2,b00 Skin absorption test with rabbits Chronic repeated exposures 1,000 b,000 Pariasry irritation :aad aaneitiautian pilot test using dried paint fUs on bsndsgas with tea fconaa voluntasr* asa* 500 fetal $ 5,900 akin '"pnteh test" on 260 hinan volunteers will coat an additional $2,000* 1h shall ba glad to answer say enactions you nay bsevs conasanalng these proposals, it is our reooaesadstien that tbs satire program ba mSlertshea in order 'to Obtain an idea of the potential hnaawd fircn paints containing phenyl asreury oleste. - ` 'iriAi'i a. Ml UAHS JWW;ed Jonathan $t,, minima Aesiatant Pirector DUP040001184