Document M9KEKYgn206XELDep2L17prM

FOftat OU>IMOO Rtv. Ml INT'KK OFFICK MKMO T'k '\ ft : ' r-'V sr \ '' >p to Dr,, R. Henderson FBOM V. C. Pitts AT 1K5 AT 1K3 subject Toxicity or Carcinogenicity of Vinyl Chloride Monomer or Polyvinyl Chloride Project 8382-000 NHTIS 74-40 Hii/stf Htefef- " date i k't i i i 12'1974 COPY TO T." r! C. (1)*^ B. I. C. (w/o att.) FEB 2 2 1974 TECH. INFO. SERV. NEW HAVEN As discussed in our recent phone conversation, I have checked through avail able recent literature for material on PVC or VCM toxicity or carcinogenicity. Your interest in an article by an Italian around 1970 on the subject was also pursued. I believe it to be one of the following: Ref. 56: Viola, P. A., Bigotti, A. (Regina Elena Inst. Cancer Res., Rome, Italy). Oncogenic response of rat skin, lungs, and bones to vinyl chloride. Cancer. Res. 1971, 31(5), 516-22 (Eng.), C.A. 76, 2374t. Ref. 61: Viola, P. Luigi (Inst. Patol. Gen. Univ. Perugia, Perugia, Italy). Pathology of vinyl chloride. Med. Lav. 1970, 174-80 (Eng.), C.A. 73 85988h. References have been indexed as follows: Carcinogenicity or Teratogenicity: 15, 19, 56, 62 Effects of Industrial Exposure to PVC or VCM (human): 4, 9, 10, 20, 22, 25, 31, 34, 37-44, 47-50, 63, 74, 76-81 Effects of Exposure to PVC or VCM (test animals): 6, 29, 56, 58, 60-65, 67-69, 71-73 Acroosteolysiss due to PVC or VCM: 2, 3, 5, 11-13, 24, 26, 27, 32, 33, 38-41, 44, 45 Electrocardiographic Changes Due to PVC or VCM: 10,53^,337,667 PVC in Medical Applications (blood bags, etc.) : 1, 7, 8, 16, 21, 28, 30, 35, 50, 57 Phthalate esters in PVC Processing, Toxicity: 7, 15, 19, 21, 23, 28, 30, 35 Tin Compounds in PVC Processing, Toxicity: 52 CPVC/Water System,.Toxicity: 55 ' OLI 2516 WHY FILE THIS COPY? IF YOU MUST RETAIN IT. SPECIFY A DEFINITE RETENTION PERIOD) ONE YEAR. (Ffl&wv B73) 1492 cuiNi s h .NICOTINE ANO CARDIOGENESIS AN HISTOCHEMlCAl STUDY/ ABSTRACT *54119 MCE 259 I99J ftfNNEOV G L CAlANDRA j c VONORUSKA J F RANCHER 0 E iHt tEKATOGEMlt POTENTIAL OF CAFTAN F0LPET AND DIFOLATAN/ ABSTRACT MAN&TER ROUSE MONKEY RABBIT RAT FUNGICIDES *2425061 * 1>>062 *13307) FACE 299*260 1994 MARCUS M 1 BECKER B A ThE |Tf A TARGET ORGAN FOB METHYL MERCURY T6RAT0GENESIS/ ABSTRACT RAT *16056341 FACE 261*262 4 1699 NOSIER M 0 JR JANSONS R A FATE OF NICOTINE IN THE RAT FETUS/ ABSTRACT ADULT TOMCiTr *54115 face 263 1466 MANGA V HANOI A AN AUTO RADIOGRAPHIC STUDY OF PERIODONTIUM IN 0STE0LATHYR1SN/ ABSTRACT RAT AMINO ACETONITRILE SULFAfEO MUCO PQIY SACCHARIDES FACE 263 1997 NOLEN G A BUEHLER E-V "CEIL R G GOLOENTHAL E 1 THE EFFECTS OF TR1 SDQIUH NtTAllO TRI ACETATE ON CADMIUM AND MfTHTL MERCURY TOXICITY ANO TERATOGENICITY IN RATS/ ABSTRACT ABNORMAL FETUSES *76404)9 *16056)41 *506431) page 244 149 OAKLEY G F SHEPARD T H possible teratogenicity of nerachlorophene IN RATS/ .ABSTRACT CLEFT PALATE *70)04 PAGE 264 1999 PRATT R M JR KING C T C EFFECT OF B AMlNQ FROFlONITRILE ON COLLAGEN CROSS LINKING IN Th| SECONDARY PALATE OF THE RAT/ ABSTRACT *151119 PAGE 265 2000 SPYKER J M SUBTLE CONSE0UENCE5 OF METHYL MERCURY EXPOSURE/ abstract mouse neurological impairment congenital poisoning *16056)41 PACE 26T ANN PARASITOL HUM COMP 46 I) SUPPLI. 1971 kurstax e POSSIBLE REPERCUSSIONS OF MICROBIOLOGICAL CONTROL ON VERTEBRATES THE CASE OF VIRUS BASED BIOLOGICAL (NSECTICIOES/ PAGE 277-211 MHO TECH REP SER 4 75 1971 - 20QZ MHO UNO EXPERT COMMITTEE ON INSECTICIOES 14TN REPORT/ PUBLIC HEALTH PESTICIDES PAGE 1-20 ********6***#********#***** i KOREAN J ZOOL 14 I)). 1971 200) 2004 2005 CM'QE S MUM H CHONG Y KMAX H POLLUTION OF HAN RIVER SEOUL KOREA/ ABSTRACT BACTERIA METAL PAGE 16) CMO K hi k POLLUTION OF LAKE EUl-AM KOREA/ ABSTRACt PLANKTON FAUNA PAGE 16* CHONG Y KANG M EFFECT OF ALKALI METAL ION ON DEVELOPMENT OF orosophila-melanogaster/ abstract sodium CHLORIDE POTASSIUM chloride CALCIUM chloride MOLTING *1004)524 *7647145 *7647407 PAGE 165 BIOL RUNDSCH 10 (l). 1972 2006 200T VON 0ERT2EN J-A MARINE POLLUTION A PROBLEM OF MARINE BIOLOGY/ PESTICIDE heavy METAL PETROCHEMICAL WASTE WATER RADIOACTIVE FALLOUT PAGE 1-18 5CHNECKE G USE ANO REQUIREMENT OF AMlNO-AdDS IN INSECTS/ HEMOLYMPH ENZYME TOXICITY D I50MER PAGE 40-46 HEALTH BULL (EDlNB) 30 (21. 1972 ELIAS-JONES T F BACTERIAL FOOD POISONING JN PERSPECTIVE/ SALMONELLA STAPHYLOCOCCUS CLOSTRID 1UN-PERFRINGENS TOX IN PRODUCTION PAGE 133*1)8 WHO IWORLO HEALTH ORGAN) CHRON 26 (7). 1972 / 151 2009 FAO WHQ ADDITIVES IN BABY POODS/ HUMAN PESTICIOE RESIDUES OE TOXlFltATION NECHANISMS PAGE 515-317 NASA TECH BRIEF 71 1104*7). 1971 2010 SMITH J M REED L L MICROORGANISM SAMPLE OEVItE/ AIR POLLUTION NO PAGE DERMATOLOGIC A (BASEL! 141 (51* 1470 2011 MATER J P D0E6LAS M M G ACUTE VITAMIN A POISONING/ ABSTRACT HUMAN PRIED HALIBUT LIVfR SKIN OE SOUAMATION *6B24 PAGE 36B--)69 NAT NEV BIOL 251 (201. 1471 2012 PEHAAN R L TOXICITY OF TISSUE CULTURE MEDIA EXPOSED TO POLY VINYL O4ORI0E PLASTIC/ NOTE CHICK EMBRYO *9002862 PAGE B5-B6 SCI PROG DECOUVtRTE 3427. 1970 201) RAHADE F BIROS PESTICIDES ANO DEATH/ POLLUTION PAGE 24-55 SEMIN HENATOl 7(1). 1970 >*************** 2014 MINES J 0 GRASSO J A THE SIDERO ELASTIC ANEMIAS/ HUMAN HEREDITARY ACOUIREO TOXIC DRUGS ETHYL ALCOHOL LEAD NUTRITIONAL PYRIOOXINE RESPONSIVE ANEMtA *7439921 *6417$ PAGE 86-106 DOWN EARTH 21 111* 1972 2015 LENG M L RESIDUES in MILK and neat and SAFETY TO LIVESTOCK FROM THE USE OF PMEMOXY HERBICIDES IN PASTURE AMD RANGELAND/ CATTLE SHEEP PAGE 12-20 Z AERZTl FORTBILD 66 (12). 19T2 2016 BENAO A CONTRIBUTION TO EYE INJURIES CAUSED BY EXPLOSIVES/ HUMAN PAGE 647*649 J FOOD SCI )6 (St. 1971 2017 2018 KUMTA U S ALU* M 0 MAVINKURVE S S LEWIS n f SPOILAGE UNITS OF RADURI2E0 BOMBAY DuC* HARPOOQN-NEHEREUS/ NOTE BACTERIA CLOSTR10lUM-BOTUlINUM PAGE 811-8S2 TIWAR] N F MAXCY R B INPACT OP LOW OOSES OF GAMMA RADIATION ANO STORAGE ON THE MICRO FLORA OF GROUND REp MEAT/ NOTE BACTERIA VECTOR FACE 831*8)4 REV MED TOURS 5 11>. 1971 2019 2020 GtRAUO P DISCUSSION OF OCCUPATIONAL HEPATITIS/ HUMAN INFECTION TOXIC SUBSTANCES FACE 243-247 GtRAUO P SOME THOUGHTS ON ALCOHOLISM IN THE LOIR-ET-CHER DEPARTMENT IN 1970/ FRANCE PAGE 249*25) OLI 2517 Dr. R. Henderson NHTIS 74-40 2- - February 12, 1974 Thermal Degradation of PVC, Smoke, Fire Aspects: 59, 66 Miscellaneous: 14, 15, 17, 36, 46, 51, 54, 70, 75 Should you need further work done in this area, please advise. VCP:rfd Attachments Sources: 1. Chemical Abstracts, 66_-77 (1967-72) Ethene, chloro 75-01-4 and Ethene, chloro, polymers, homopolymer, 9002-86-2 2. Toxicity Bibliography (Nat. Lib. of Medicine) Volumes held by Library, 1970-73 3. Abstracts on Health Effects of Environmental Pollutants (HEEP), 1972-3 4. NHTHIS 74-3, 73-11, 72-3 on Polyvinyl Chloride - Current Awareness (1972-74) 5. Guide to the Literature and Patents Concerning Polyvinyl Chloride Technology, L. R. Whittington, ed., SPE, 1963. OLI 2518 213 [March, 1973] The 1st paper covers pesticides and their contributions to chemical epidemiology, followed by a discussion on the background of the D pharmacology of DDT. The next several articles describe problems of O prevalence of pesticide residues in humans, an epidemiologic appliesP tion of the study of DDE levels in whole blood, transplacental passage X of pesticides, and correlation of prematurity and DDE levels in fetal 2 whole blood. Next, a survey is Included on DDT and DDE in blood samples of occupationally exposed workers, followed by a paper on levels of DDT and DDE in blood and DDA in urine of pesticide formulators following a single extensive exposure. The next several papers discuss the following topics related to the epidemiology of DDT: DDT and DDE in blood and DDA in urine of men exposed to 3% DDT aerosol; effects of anticonvulsant drugs on DDT residues in man; drug and environmental effects of DDT residues in human blood; comparison of whole blood DDE levels and adipose DDT residues in man: and the effects of phenytoin on human residues of DDT and dleldrin-a com pendium. The next paper, DDT in man, presents a summary and re view of DDT investigations and their potential impact on the under standing of chemical epidemiology, followed by a paper on a simplified method for analysis of DDT and DDE in blood for epidemiologic purposes. The final 2 papers discuss reproducibility of micro-Mills procedure for pesticide residues in fat, and determination of DDT and metabolites, including DDA, in human urine by gas chromatography. The book ends with a related bibliography and a list of contributors to this volume. Selected papers will be indexed in BIORESEARCH INDEX.--W. H. M. 2693. CARP, E. [Ed.]. International Conference on the Conservep tion of Wetlands and Waterfowl. Ramsar. Iran. 30. Jah. 3. Feb. 1971. fi 3Q3p. Dlus. International Wildfowl Research Bureau: Sllmbridge * (Glos.), England. 1972. Paper.--This book sets out the text of the * Final Act of the Conference and contains a summary record of its proceedings. The need for a wetlands convention was felt in 1962 at the fotemational Conference on Wetlands held in France. There, it was decided that a list should be compiled of European and North African wetlands of international importance. This final text of the convention is therefore the result of 9 yr of careful study and inter national coperation among scientific and legal experts of a great number of countries, and several international organizations. The conference adopted 11 recommendations for consideration and ap propriate action involving the following topics: conservation of the Wadden Sea, northwestern Europe; conservation of Thjorsarver, Iceland; conservation of North Bull Island, Ireland: conservation of Lakes Ab-t-Istada and Dasht-e-Nawar, Afghanistan; conservation of the Medway Estuary, England; oil pollution; pesticides; promotion of wetlands research; promotion of hunting research and education; African wetlands; wetlands and the Man and the Biosphere Program. The book will be of interest to individuals and agencies involved in the conservation of wetlands. Selected sections will be indexed in BIO RESEARCH INDEX.--W. H. M. 2694. OGLESBY, RAY T., CLARENCE A. CARLSON and JAMES A. MC CANN [Ed.]. River ecology and man. Proceedings of an inter ft national Symposium. Amherst, Massachusetts, June 20-23, 1971. T xvii+463p. nius. Maps. Academic Press: New York, N.Y., U.5-A.; W London, England. 1972. Pr. SlI.SO.--This book contains an integrated Z series of reports by scientists, engineers and social scientists on rivers and man's Interaction with them. Information included presents descriptions of the flora, fauna, chemical composition and geomorphometry of rivers; case histories of specific rivers throughait the world; full discussions of the effects of various river uses on morphometry, discharge, and sedimentation; detailed analyses of the impact of heat, radionuclides, pesticides, and industrial wastes on river ecosystems; and the economic, environmental, and political Implication of multiple use of rivers. The content begins with a section describing what a river is, including a geomorphic and chemical overview, a zoological description and plant ecology in flowing water. The 2nd section, uses of a river--past and present, covers man's Impact on the Columbia River, a study in water quality management on the Delaware River, man and the Illinois River, a case history of the Nile River and the River Thames and the uses of the Danube River. The 3rd section, effects of river uses, covers the following topics: regulated discharge and the stream environment; morphometric'changes; sedimentation; a comparative assessment of thermal effects in some British and North American rivers; effects of pesti cides and Industrial waste on surface water use; radionuclides in river systems; and nutrients. The final section, rationalization of multiple use, discusses multiple use of rivers and of river systems and political aspects of multiple use. The book ends with a summary of the papers presented at the symposium. Selected papers are in dexed in BIORESEARCH INDEX,* Vol, 8.--W. H. M. 2695. ZARKOWER, A, and W. MORGES. (Dep. Vet. Sci., Pa. X State Univ,, University Park, Pa. 16802, USA.) Alteration in anti body response induced by carbon inhalation:*, A.model system. INFECT IMMUN 516): 915-920. Ulus. l^JV-iThe Immune respotise in mice to antigens [Ag] given by i.p., l.v., and inhalation routes was compared in control and C-dust exposed mice. The 2693*2701 most pronounced effect, a decrease in antibody [Abl-forming cells and serum agglutinin titers, was observed when the C-treated ani mals were immunized with Ag in the form of aerosol. Similar re sults were obtained when the Ag were administered by l.v. or i.p, route. In contrast 4-days of preexposure to C dust increased the , number of Ab-forming cells in the mediastinal lymph nodes. This effect was transient and was not significant when the C pre-exposure was continued for 15 days. 2696. MEYERSON, LAWRENCE B. (Irving Med. Prof. Village, 2101 MacArthur Blvd., Irving, Tex. 75061, USA.) and GERHARD C. MEIER. Cutaneous lesions in acroosteolysis. ARCH DERMATOL 106(2): 224-227. Ulus. Td72.--A patient with idiopathic acroosteoly sis had unique papular skin lesions. Evidently, similar lesions were previously mentioned only in connection with acroosteolysis seen in vinyl chloride processing, and a detailed description of these was not noted in the literature. q 2697. LEE, RICHARD F., RICHARD SAUERHEBER and A. A. BENSON. (Scrlpps Inst. Oceanogr., Univ. Calif,, La Jolla, Calif. 92031, USA.) Petroleum hydrocarbons: Uptake and discharge bv the " marine mussel Mytllus edulls. SCIENCE (WASH) 17714046': 344- z 346. 1972.--The common marine mussel M. edulis was observed to rapidly take up mineral oil, (14C]heptadecane, 1,2,3,4-tetrahydronaphthalene, [14cJtolueue, [Mcjnaphthalene, and [3h]3,4-benzopyrene from seawater solution. This species of mussel did not metabolize any of these compounds, and transfer of the mussel to fresh sea water, after exposure to the hydrocarbon In solution, resulted in the discharge of most of the hydrocarbon, although significant amounts remained (between 1 and 400 micrograms per mussel). The nontoxic paraffinic hydrocarbons mineral oil and heptadecane were taken up (10 milligrams per mussel) to a much greater extent than the aromatic hydrocarbons (2 - 20 micrograms per mussel). 2696. ZAWIRSKA, BOZENNA and KAZIMIERZ MEDRA5. (uL Marctnkowskiego 1, Wroclaw, Pol.) Morphology and biological activity of transplantable lnterstltioma testis Induced with lead acetate. ARCH M ImMUn6L THER EXP 20(2): 243-256. IlluS. 1972.--Transplantable lnterstltioma testis, Induced In Wistar rats by prolonged feeding of lead acetate, showed discordance between a morphologically benign structure and the tendency to extensive roetastasee, mainly to the lungs, lymph nodes and Uver. Its hormonally determined growth caused nonneoplastic and neoplastic proliferation In the hypophysis, adrenals, thy roid, parathyroids and mammary glands. Changes In the genital or gans of males and females Indicated hormonal, especially feminizing, activity of transplantable lnterstltioma. Interstitial testicular and ovarian cells reacted differently to hormonal stimuli. 2699. GLADEN, R. (Robert Bosch GmbH, Tech. Zentrum Forsch., D-7016 Gerlingen, West Ger.) Die Besttmmung cancerogener polvcyclischer aromatlscher Kohlenwasserstoffe Im Kraftfahrzeugabgaa durch Saeulen-Chromatographte. fThe determination of carcinogenic polycyclic aromatic hydrocarbons In automobile exhaust gases by column chromatography. 1 CHROMATQGRAPHIA 5(4): 236-241. Ulus. 1972. (EngL and Fr. summ.]--A process Is described for de termining 12 polycyclic hydrocarbons in automobile exhaust gases by separation in a chromatographic column and subsequent quantitative UV photometry. In contrast to other methods, no special purification of the condensed exhaust components Is necessary, the solution of the test specimen In cyclohexane being treated with a potash solution to remove acid components. The chromatography is carried out In a Sephadex LH 20 column with isopropanol as the eluting agent. The un wanted exhaust gas components are eluted before the polycyclic hydro carbons to be determined, the latter being distributed between 8 frac tions. The particularly important benzo(a) pyrene forms a fraction by itself and is well separated from benzo (g, h, 1) perylene, which pos sesses an extremely similar UV spectrum and could Interfere with th, determination of benzo (a) pyrene If the separation were Imperfect. As an application of the method, the separation and quantitative deter mination of polycyclic hydrocarbons In the exhaust gases of a small single-cylinder test engine is demonstrated. _ _ 2700. KELLEN, J. A. (Dep. Clin. Biochem., Banting Inst., Univ. 2 Toronto, Toronto 181, Ont., Can.) Failure of transplancental tumourinduction In rats bv 7.12-dlmethvlbenz(o) anthracene. RES COM MV N CHEM PATHOL PHARMACOL 4(1); 135-140. 1972.--Prenatal ex posure to 7,2-dlmethylbenz(o)anthracene (DMBA), Injected 5 days be fore or after mating Sprague-Dawley rats, failed to Induce tumors in the offspring during an observation period of 200 davs. Precnancv and subsequent lactation protected the mother rats from tumor induction. The possible mechanisms of this protection were discussed. 2701. BAUER, L. (PathoL Inst,, Univ. Erlangen-Nuernberg, Krankenhausst. 8-10, D-8520 Erlangen, West Ger.), A. H. T ULUSAN and E. B MUELLER. Ultrastructural changes produced by the carcinogen, alia- U toxin Bi. Indifferent tissues. VIRCHOWS ARCH ABT B ZELLPATHOL Z 10(4): 275-285. Illus. 1972.--In the present comparative study, tissues O LI 2519 V> -sv^--n-- 2780-2791 J [VOI. 2 No. 3] 222 2780. BLUM, KENNETH (Dep. Pharmacol., Univ. Tex. Med. Sch., Z San Antonio, Tex., USA.), JACK E. WALLACE, RALPH S. RYBACK and IRVING GELLER. Diethanolamine: A possible weak aron.ir.tahtagonist to ethanol. EUR J PHARMACOL 19(2): 218-222. Ulus. 1972.--Diethanolamine-rutin (DR) and dimethoxyethylamme-rutm (DMR) were studied for their effectson ethanol-induced sleep time in mice. The DR-ethanol curve was shifted to the right of the salineethanol curve indicating a DR protection against ethanol-induced sleep. Blood- or brain-ethanol levels were approximately equal for both treatment conditions suggesting that DR`s protective action was not due to a lower blood- or brain-ethanol level. In contrast, the DMR-ethanol curve was shifted to the left of the saline-ethanol curve indicating an enhancement of ethanol-induced sleep time. This action of DMR is probably not due to an effect on ethanol metabolism, since no signif icant difference was found in blood- or brain-ethanol levels in this group relative to the saline-ethanol mice. Attempts to demonstrate antidotal activity for DR were unsuccessful in that treatment of mice with DR after ethanol administration prolonged sleep time. It is suggested that diethanolamine acts as a weak agonist-antagonist to ethanol in the CNS. 2781, MCQUEEN, E.G. (Dep.Clin. Pharmacol., Med.Res. Counc. p N. Z,, Univ. Otago Med. Sch., Dunedin, N. Z.), DIANE OWEN-and D. G. 7 FERRY. Effect of nhcnvtoin and other drugs in reducing serum DDT levels, tTZ MED J 75(479): 208-211. Ulus. 1972.--Patients on long-tsAn anticonvulsant treatment with phenytoin (diphenylhydantoin) have markedly reduced blood levels of DDT-derived materials. Establishment of reduced equilibrium levels appears to take some 12 mo. Althcugh phenytoin is especially effective, long-term treatment with a wide variety of other therapeutic substances also reduces blood levels of DDT-derived material. Possible mechanisms determining the reduction are discussed. 2782, JONES, R.D. (Pharm. Div,, I. C. I. Ltd, Alderley Park, M Macclesfield, Cheshire, Engl., UK,), B. T. COMMINS and A. A. CERNIK. Blood lead and carboxvhaemogiobto levels In London taxi U drivers. LANCET (NORTH AM ED) 2(7772): 302-303. 1972.--Amcng z 50 London taxi drivers the mean blood-lead was 28.7 Mg/100 ml. There was no difference of statistical significance in tbe blood-levels of smokers and non-smokers, nor between the blood-leads of night-shift and day-shift drivers, Carboxyhemoglobin levels of smokers were significantly higher than those of non-smokers, and the levels were significantly higher In day drivers than in night drivers. A 2783. MC INTIRE, MATILDA S. and CAROL R. ANGLE. (Dep. M Pediatr,, Univ. Nebr. Coll. Med., Omaha, Nebr. 68105, USA.) Air lead: Relation to lead in blood of black school children deficient in giucoee-6-phosphate dehydrogenase, SCIENCE (WASH) 177(4048): 520-522. Ulus. 1972.--Black children (44) at 2 elementary schools within 0,7 ml of a battery plant had eignlflcantly higher (P<0,01) concentration* of Pb In their bloods (34.1 + 9.7, ug/lOOmm, mean + SD) than 122 atudents (26 J + 7.1) at 7 schools 1-3 mi distant; 5 mot later there was a comparable difference between red cell Pb values (54J + 18.5 vs. 37,4 + 12.6), Among the blacks, those deficient In glucose-6-phoephatedehydrogenase had a higher (P<.005) concentra tion of Pb in the blood after correction for anemia (32.9 - 9,7) than the nondeficient (25,7 + 8.8), and a higher concentration 5 the red cells (47 J + 14.7 as compared to 35,8 * 15.8 P< .001); the enzyme . effect was independent of geographic location. 2784. MARKOWITZ, SAUL 5,, CHARLES J. MC DONALD (Roger O Williams Gen. Hosp., 825 Chalkstone Ave, Providence, R. I. 02908, z USAJ, WILLIAM FETHIERE and MARVIN S. KERZNER. Occupational acroosteolysls. ARCH DERMATOL 106(2): 219-223. IUus. 1972.-- Occupational acroosteolysls is an unusual disease in which affected peraons have sclerodermoid-like lesions of the skin, conditions similar to Raynaud's phenomenon, and asymptomatic, bony defects of tbe extremities. Evidently, the disease la confined solely to workere in the plastics industry, specifically those engaged in the production of polyvinyl chloride from vinyl chloride. The incidence of the disease is unknown tait Is thought to occur in 3% or less of workers. 2785. JOSE, FRANCISCO R. (Dep. Physiol. Hyg, Nutr., Univ, A Philipp,, Manila, Philipp.) A study of lead hazard in some lead processD tag industriesr ACTA MED PHILIPP 8(2): 48-54, 1972.--Two tatt le tery plants, 2 paint establishments and 1 company manufacturing lead q oxide were studied to evaluate the extent and intensity of pb hazard. Methods of evaluation used were levels of Pb in air, and urinary Pb, stippled red cell count and clinical manifestations suggestive of Pb intoxication among employees in the establishments. Levels of Pb In air, Pb concentration in the urine and stippled red ceU count were higher in the lead oxide and battery plants than m those engaged in paint manufacturing. Clinical manifestations suggestive of Pb poisoning were also more frequent. Good correlation was observed between the laboratory findings and the clinical manifestations indica tive of mild Pb poisoning. 2786. GOODWIN, JOHN W. (Day, Zimmermann, Inc., Lone Star Div,, Texarkana, Tex. 75501, USA.) Twenty years handling TNT in a shell loading plant. AM IND HYG ASSOC J 33(1): 41-44. Ulus. T972--In the handling of TNT within the munitions industry, human exposure to this substance cannot be completely avoided. The goal of a Preventive Medical Program is to prevent such exposures from causing any permanent damage to workers. Exhaust ventilation with wet scrubbers, use of protective clothing, mandatory practice of good personal hygiene, and careful medical supervision have combined to accomplish this goal. The use of tbe Thymol Turbidity Test in such a program was a valuable Indicator of liver malfunction. o z 2767. KRAMER, C. G. (Dow Chem. Co., Midland, Mich. 48640, USA.) and J. E.MUTCHLER. The correlation of clinical and environmental measurements for worker* exposed to vinyl chloride, am IND HYG ASSOC J 33(1): 19-30, Bins, 1972.--A method is described for the statistical consolidation and correlation of environmental measurements and clinical findings using as an example a group of healthy male workers exposed routinely to vinyl chloride for periods up to 25 yr. Retrospective in nature the study reveals several statis tically significant effects from chronic exposures to vinyl chloride and tracts of vtaylidene chloride. O Z 2788. EL-DAKHAKHNY, ABDEL-ARIZ and YASSIN M.EL-SADK. (Dep. Occup. Health, High hist. Public Health, Alexandria Univ,, Alexandria, UARJ Lead in hair among exposed workers. AM IND HYG ASSOC J 33(1); 31--34. Illus. 1972,--In a study performed on 67 Pb exposed workers, a correlation waa found between levels of Pb in hair and the biochemical and clinical findings, A Pb level in hair ta more than 30 pg/g could be considered as a sign of excessive Pb level. m J? 0 2794. LAUWERYS, R,, R. DELBROECK and M. D. VENS, (Unite Toxicol, Pathol. Travail, Catholic Univ. Louvain, Ave, Chapelle-aux Champs 4, 1200 Brussels, Belg.) Automated analysis of delta-amtaolaeyultalc acid to urine. CLIN CHIM ACTA 40(2): 443-447. Ulus. 1972.--The addition of an Internal standard of 5 -aminolevulinic acid to the urine allows the colorimetric determination of this metabolite without the need of a preliminary chromatographic separation. The peed and accuracy make the procedure suitable for the periodic control of workers exposed to Pb, D M O 2789. MDCS1C, J. and S. HUKOVIC. (tost. Farmakol. Tfksikol., Med. Fak., Sarajevo, Yugosi.) Uxroct nastajanja kronicnog opstruktiv- nog brouhitisa u radnika cine metahirgije. fCausea of chronic obstruc tive bronchitis in ferrous metallurgy workers^ ARH HIG RADA M TOKSKOL 22(1): 6-32. Ulus. 1971[recd.l97i]. [Engl, summ.]--An O analysis was performed on 400 people working and living under differ ent conditions of exposure to air pollution. Respiratory symptoms were questioned and the ventilation function of the lungs, O. and CO2 content of arterial blood, presence of allergic phenomena, data on smoking habits and the consequences to pulmonary and cardiovascular systems were studied. The 8 metal Ions that constituted the dust were Investigated. Experiment* were also performed on frogs (Rana ridi- bunda).--J. F. L. 2790. FROLOVA, A. D. fOO the methods of studying blotransfnrma- tfon erf poisons to organisms.! PRAC LEK 24(2/3): 61-66. 1972. P [Czech, and Engl. Juram.j--The mechanism of the toxic effect of Z industrial polsoos was discussed. The lack of methods lot identifica tion of chemical substancss and products of their transformation m biologic material, made these studies rather difficult. Simple methodic approach affording indirect assessment of the fate of foreign substances to the organism had not yet lost its importance. The effectiveness of proposed simple procedures for studies of the fate of poisons was demonstrated with 3 representatives from tbe series oi fluorated compounds.--J. A. L. 2791. FISEROVA-BERGEROVA, VERA (Reprints: Vera FlserovaBergerova Thomas, 145 S.E. 25th Road, Miami, Fla. 33129, USA.) and J. LUDVHC CETTL. Elektricky model pro vstrebavani metabolismus a vyhicovanl btnzemi u cloveka. [Electric model for the absorption metabolism and excretion of benzene to man.) PRAC LEK 24(2/3): 56-60, IUus. 1972* [Russ/and Engl, summi]--TT,ie values for the resistance and capacities m the electrical analogue were derived by analogy 10 physiological factor* for a 70 kilo man (blood flow m tissue, lung ventilation, tissue volume and tissue capacity to absorb benzene). The partition coefficients for benzene between tissue and air and the metabolic coefficient were other limiting factors, Hie model was elaborated for a 3-compartment system and solved on an analogue computer (MEDA 40 T). Hie calculated rates of uptake and excretion of benzene through the lung were compared with experimental values. It was possible to predict the levels of toxic compounds in individual tissue compartments, and the velocity of their uptake and excretion, --J. A. L. z O LI 2520 I -^^-1ttlV|l',t,t *H ' ' ^-'- --''*^` ^1----- 4227-4236 transplacental cnrrinogrnrsis (vaginal and cervical adcmwarnnoma) by stllbestrol arc discussed RES is rojxirtedlv linked i<> rawer nr*1 the vagina in young women whoso nnMhi-r* took DES during iH'fgnancv some 15 to 20 yr ago. Chlorinated hydrocarbon, heavv metal, and antibiotic residues; the food additives nitrate, nitrite; and new pnltrv on animal toxicity studies of contraceptives. eMrui'en-s and prugestngens are mentioned.--P. L. W, 4227. COMMITTEE OF GOVERNMENT OPERATIONS. SCBCOM- MTTTEE ON INTERGOVERNMENTAL RELATIONS. HEARINGS Regu- lation of diethylstilbcstml: Its use as a drug for humans and in amnul J feeds: II. U S~CQNGR HOUSE 92ND. 1ST~SESS.~DEC 13. 1971, U2* 352.--Hearings evaluated carcinogenicity of diethvlstiUiesiroi <dES). low level environmental carrimitfriis, food .iddmvi's. .imiliiouc drutgi. meat and poultry OES residues.--P. L. W. - 4228. COMMITTEE ON GOVERNMENT OPERATIONS. SL'DCOM- p MITTEE ON INTERGOVERNMENTAL RELATIONS. HEARING. The - aalety and effectiveness of new druid., Markei iihdr.i"iit iif drugs eontalnine cvclamates u S CONGR HOUSE 92ND. 1ST SESS. MAY S. 1i. V4 .--Hearings were held for evaluation of the views of the various organizations interested in cyclamate containing drugs and food additives.~P. L. W. ' 4226. ALEXANDER. W, G. Welding hazards PROC MINE MED q OFF ASSOC S AFR 49(406): 98-100 19^6^--A case with dermatitis tyj of both arms and eyelids due to prolonged intimate exposure to the UV and IR rays of the electric welding are prompted study of welding p hazards in the mines in South Africa. European welders who have _ had long exposure to IR and UV ravs develop sensitivities to such an * extent that, if they wish to continue working they have m work behind a copper screen or apron. Skin carcinomata are also noi uncommon. A Bantu's skin pigmentation protects him only fn>m the light-rays, but not the heat-rays after years of exposure Exposure to IR and UV rays initially decreases sweat secretion then causes small blisters and desquamation. If exposure is great 2nd degree bums can he caused with big blisiers--thlj is equivalent in sunburn and solar dermatitis. The UV rays of electric welding cause retinal damage while the IR rays damage the lens and are a direct muse of cataract. These cTfects are cumulative. In all types of welding then' is a danger of exposure to fume* in badly ventilated areas. Nitrous fumes. COj. acetylene and impurities as well as silica and asbestos (from covered rods) can accumulate in a welder's hood if it is not adequately ventilated. When welding or cutting ts done on galvanized material in badly ventilated areas, Zn fumes are inhaled that cause headache, nausea, thirst, pains in the Umbs and a feeling or exhaustion. No longterm poisoning occurs and the temporary effects arc never serious. These symptoms also oecur with exposure to fumes of copper, magnesium, aluminium, antimemy. cadmium, manganese, nickel, selenium, silver and tin. Exhaust ventilation will prevent inhalation. To prevent the effects of beat rays in welding and allied occupations, protective clothing should be provided. Welding bays should be constructed and painted pink to absorb the heat rays best. Welding operations can and do cause per manent disability over longer and shorter periods depending on the degree of exposure.--P. L. W. 4230. LOSKANT, H- Industrial health service today. ZENTRALBL q ARBEITSMED 22(8); 228-231. 1872.--The"function of the industrial physician is no longer limned to maintaining healthful conditions and preventing accidents and to recognizing physical and psychic factors that might impair the health of workers. Industrial medicine reaches out today to the physical and mental health of workers in maintaining optimal relations between work performance and the worker's physical and psychic capacity to perform the work. This brings the industrial physician into the area of work rhythm* work pause* and the evaluation of difficult conditions at work.--P. H. V. I 4231. TAYLOR. W. The weavers f Dundee. TRANS SOC OCCUP q MED 22(2): 37-43. 1972.--A retrospective Ytudv of the Dundee female y weavers using 493 ears determined the progressive deterioration with time up to 50 yr exposure to loom noise, of the purc-tone air conduc tion threshold audiogram. Comparison or the hearing levels with agematched. non-noise exposed controls showed that the weavers suffered considerable losses, especially in the frequency range of 2kH and above. Median estimated threshold shifts of 50 dB were round at 2. 3. and 4 kH after 40*45 yr of loom noise exposure.. Two test populations each of 20 subjects with normal hearing (age range 17-35). 1 group in Dundee and the 2nd in Southampton achieved 50'. phoneme scores at 65 dB(A) peak level at the ear for fare to face conversation against the 60dB(A) masking noise Speech audiometry was conducted on the weaver and control populations. Martv weavers with srvere hearing impairment could not understand speech at any level The mam handi cap concerned difficulties experienced in communication Amongst the weavers there was a striking difference in the ownership of tele phones (8*7) compared with 58% in the control group, reflecting dis satisfaction with the instrument as a means of communication. Despite the high proportion of weavers who considered their hearing worse than normal (81% compared with the controls S'. ) only 8 of this weaver population of 96, i.c. 9% . had a hearing aid and only 5'. used an aid regularly.--P. L. W, 5~ [V0I.2 No. 5} 316 4232. MC LINTOCK .1. S. Principles of the control of occupational disease. TRANS SOC OCCUP MED 22(3): 79-82. f9T2 --The 1st and q major step in the control of any occupational health problem is to try j to alter the environment and thu$.climinato the problem. If. however, y it Is not possible u> be sure that the problem ts completely eliminated, then in addition to environmental measurement it is essential to moni tor regularly the health of the exposed population. The purposes of periodic X-ray examinations are 2-fold: to identify the earliest stage of change and to try to control the workman's further exposure, to measure the efficacy of preventive measures and thus to demon strate those places where more effort is required. The chest radio graph is a useful tool in certain of the pneumoconioses. X-rays of l*nne probably have a useful role in workers in compressed air and possibly in men operating certain vibrating tools. The value of radiography in measuring bony changes in the spine is quite uncer tain. and the X-ray dosage involved raises ethical problems in any system of periodic spinal X-rnyi. The principles involved in using radiology as a control measure are the: validity of the X-ray appear ances. periodicity of examination, representative nature of the popula tion examined, standard and consistency of the quality of films, inter pretation of the radiographs, use of the results. A sophisticated sta tistical approach is necessary if the epidemiological results are to be used successfully to improve environmental conditions.--P. L. W. 4233. JACOBSEN. M. Evidence of dose-response relation In pnrunmronliM.s: D. TRANS SOC OCCUP MED 22(3): 18-84. 1972.-- O Recent interim reports of 3 long-term epidemiological studies of X dnse-rrsponsc relationships in pneumoconioses are discussed with special reference to the problems of methodology and Inference in herent in the abandonment of the clinical or laboratory setting. All reports conclude with quantitative statements relating the dose of inhaled dust to the risk of developing radiologicaily defined pneumo coniosis. They arc concerned with silicosis among European gold miners in South Africa (Beadle, 1971). and coalworkers' pneumoconio sis in the Ruhr coalfield (Retsner, 1971) and in Great Britain (Jacob sen. et. a!.). The 3 studies are compared epldemiologically under the headings of subjects, stimulus and response.--P. L. W. 4234. SCHWET2, F. Are hearing tests necessary during continued work )n a noisy environment? MONATSSCHR OHRENHEILKD 0 LARYNGORHINOL 106(7 8): 344-352 1972.--According to lome f authors, occupational hearing defects due to excessive noise do not develop after the 22th or 15th yr of work. From that time on, the auditorv thresholds in the upper frequency range are expected to shift for reasons of the person's age only. If this reduction in the hearing capacity were general, most of the time- and money-consuming audio- metric tests, which the individual person exposed to excessive noise at work has to undergo till his retirement, would not be necessary. Observations extending over several years have shown that the hearing loss may be aggravated even a long time after a person has retired from work involving excessive noise. Both old and young workers may be affected by this phenomenon, as well as workers whose hearing was only slightly impaired before or whose hearing was characterized by a pronounced "resistance to noise." The possible causes for such a "late- reduction in the hearing capacity are discussed. Specific hearing tests are still required for a final clarification. In the interest of the persons concerned, such a reduction in the hearing capacity must not be overlooked. Regular check-ups are necessary during the time the .person is exposed to excessive noise at work.--C. M. M. 4235. DANJOU. P. Collective alimentary lead poisoning aboard a tanker, REV CORPS SANTE ARMEES 13(31: 255-283. 1972.-- Pipes soldered with a high Pb mixture, placed in the bottom of a wine vat on board on board an oil tanker, caused severe Pb poisoning in 7 members of the crew and mild or asymptomatic intoxication in 13 others of a crew or 33 on a voyage from France to the Persian Gulf via Cape Town. South Africa. Physicians who boarded the vessel in the Gulf failed to diagnose the intoxication. This was discovered in Cape Town on the return trip, after 2 patients were hospitalized there and samples of the wine analyzed.**P. H. V. I. p ^ q 4236. ' CHRISTOPHERS, A. J. Occupational aspects of Raynaud's disease: A critical historical survey. MED J AU5T 2(13): 735-733. O 1^72.--The literature is reviewed beginning with the 1st descriptions T of occupational Raynaud's disease (bone resorption and disturbed blood supply of the extremities in the 2nd decade of this century). At the beginning of the 4th decade, the importance of vibration in the etiology of the disease was indicated. This idea solidified during this decade and the next to the extent that the disease is now called "vibration disease,'* or ' vibration-induced white fingers." instead of "Raynaud's disease," Vibration was accepted erroneously as an etiological factor, and the perpetuation of this error has confounded investigations into the etiology of the disease. Certain polyvinyls chemically-induced occupational manifestations-of Raynaud's disease were recently described as a new disease named "occupational acroosteolysis" and spurious etiological factor^ werF postulated for it. Vibration is not a necessary predisposing-faetde. as attacks take place in persons who have not been exposed to it.* The occupational factor that stands out as being the most likely predisposing cause is repeated chilling of the body and or of the hands.--P L. W. OLI 2521 373 [May, 1973] 4820-4832 towards normalization, the intraatrial conduction was restored in some cases. Roentgenological studies revealed enlargement of the left ven* triele of the I and U degree in 25% of the cases. There was an increase of the cholesterol level and 0-lipoprotein fraction. These changes de pend directly upon the duration of the disease.--G. S, 4820. ELETSK3T, Yu. K. (Dep. Cytol. Histol., N. I. Pirogov 2nd Z Mosc, Med. Inst., Moscow, USSR.) Vhyanie ostroi alkogol'noi intoksi- katsli na cki&htel'noe fosforilirovame v pecheni krys. [Effect of acute alcoholic intoxication on oxidative phosphorylation in the liver of ratsT] FARMAkfiL T6KSHi6"L "35(2): 198-199;"1972'. [Engl. summ,]--Tests conducted on rats demonstrated that introduction of alcohol tn a dose of 11 ml/kg causes a fall of the P/O factor in 15 min. Changes reach their peak by the end of the 1st 24 hr with normalization setting in to* wards the end of the 8th day.**A. F. K. 4621. BLOCK, ROBERT A. (Dep. Obstet., Gynecol., Thomas Jef- Z fersoo Univ. Hosp., 1025 Walnut St., Philadelphia, Pa. 19107, USA.) Pregnancy ini portal cirrhosis: A case report. J REPROD MED 8(3); 143-145. 19727--Liver function studies were made during and after pregnancy in a 39-yr-old alcoholic with portal cirrhosis. After 5 mo. these studies were re-evaluated as to the effect of exogenous ethyoyl estradiol. The abnormalities of the liver function were a result of the continued alcoholic intake, and were not affected by either the preg nancy or the exogenous estradiol.--J. J. B. " 4822. DENNISON, C. (Natal Agric, Res. Inst., Pietermaritzburg, U S. Afr.), R. H. STEAD and G, V. QU1CKE. A non-haemagglutinating Z toxic factor from the lack bean (Canayalia ensiformis^. AGRQPLAnT- AE 3(2); 27*29. lllus. 1971(recd~1972). [Afncaans and Fr. summ.] -- A method was developed for the preparation of a toxic, hemagglulmating crude extract of jack beans, which is devoid of trypsin inhibiting activ ity, The toxic and hemagglutinating activities were subsequently sepa rated by selective adsorption of the hemagglutinin (concanavalin A) onto Sephadex G-100, demonstrating that these activities are due to 2 dis tinct molecular entities. The toxin was further purified by chromatog raphy on Sephadex G-200.--E. S. 4823. MAGOS, L. and W, H. BUTLER. (Med. Res. Counc. Toxicol. M Unit, Med. Res. Counc. Lab., Woodmansterne Road, Carshalton, Surrey, p Engl., UK.) Cumulative effects of methyimercury dicyandiamide given r orally to rats." FOOD COSMET TOXICOL l6(4): 513-517. Illus7 1972. --The changes in Hg levels in the tissues and pathological changes in the brains and kidneys of rats given daily oral doses of methyimercury di cyandiamide are described.--J. E. F. 4824. JAROGS, WERNER (Med. Akad. Carl. Gustav Carus, Abt. Z Klin. Lab,, Fetscherst. 74, 8019 Dresden, East Ger.), MARKOLF HANEFELD, KLAUS ULRICH SCHENTKE, ALBRECHT TRUEQSBACH, HORST STOETZNER, WOLFGANG LEONHARDT, VINCENT HERRMANN and RUDOLF FUCHS. Veraenderungen von metabolischen Parameters, insbesondere des Fettstoifwechsels bei chromschen Alkoholikern unter klinischer Alkoholkarenz. [Changes of metabolic parameters, especial ly fat metabolism in chronic alcoholics under temperance.1 Z GESAMTE INN MED GRENZGEB 27(7): 311-316, 1972. [Engl, and Russ, summ.]--In 41 otherwise healthy chronic alcoholics immediately after admission Into a sanatorium for alcoholics as well as after a 7 to 14 days* temperance apart from numerous examinations of the blood, Menghinl-punctures of the liver were carried out. Within an average of 10 days the fatty change of the liver decreased. The flowing off of the triglycerides seems to be carried out exponentially. Id uncompli cated alcoholic fatty livers a half-value period of the triglycerides of the liver of about 4 days is calculated. During the period of temperance the free fatty acids, the phospholipids, cholesterol and bile acids signif icantly decreased in the serum. At the same time an ascertained de crease of the uric acid, of bilirubin, the glutamic oxaloacetic trans aminase, of total protein and of the y-proteins could be proved, whereas the albumins increased. In lipid electrophoresis most frequently there was an increase of the a-llpoproteins in the 1st examination, which rapidly receded. There was a highly significant connection between daily alcohol dose and fasting level of the free fatty acids.--P. L. W. 4825. TATA, J. R. (Natl. Inst. Med. Res., Mill Hill, London, Engl., B UK.), MARY JO HAMILTON and D. SHIELDS. Effects of a-amanitin U in vivo on RNA polymerase and nuclear RNA synthesis. NAT NEW" Z illOL 238(84); 161*164. lllus. 1972.--The fungal toxin o-amanitin given In vivo selectively inhibits for 10-60 min a nucleoplasmic type of RNA polymerase in rat liver but the synthesis in vivo of all species of nuclear RNA remains blocked for several hours.--J. F. L. 4026. BROOKS. ROBERT B- Jr. and JAMES A. VICK. (Dep. Ph.irmy acol.. Walter Reed Army Inst. Res., Walter Reed Army Med, Cent,. 2 Washington, D. C. 20012, USA.) Toxicological studies of bee venom in mice, dogs and monkeys. AM BEE J 112(7): 250-251, "1972,--Venom of Apis melhfera was injected, either i.v. or s.c., into experimental animals. I.V.lhjedions caused a precipitous decrease in blood pres sure within 35 sec {p both flogs and monkeys. It also decreased heart rate and depressed respiration. Dosages of 5 mg/kg in dogs, or 2.5 mg/kg in monkeys, i.v., caused death from cardiovascular failure. Similar responses were noted after s.c. injections, but median lethal dosages were higher: 200 mg/kg in dogs and 50 mg/kg in monkeys. The former is equivalent to about 2000 bee stings. Smaller dosages were fatal to mice, Ckher physiological reactions are noted. --J. D. Hitchcock. 4827. KOBULIYA, N. S,, L. E. GEDYMIN, F. R. CHERNYAKHOVSK1I and O. P. ARKHIPOVA. (Cent. Res. Inst. Tuberc,, G Mimst. Health USSR, Moscow, USSR.) Izucheme promtsaemosti gisto- T gematlcheskikh bar'erov pri razlichnykh rezhimakh giperbarichcskoi oksigenatsu v eksperimente. (Permeability of histo-haematic barriers in different regimes of experimental hyperbaric oxygenation.I EKSP KHIRANESTEZIOL 17(2): 31-33. lllus. 1972. [Engl, summ.]--Eapenmentally, 70 guinea pigs were subjected to 100% Oj in therapeutic (1-2.2 up to 3 ata) and toxic (4-5 ata) regimes of hyperbaric oxygena tion for 1-4 hr. Histology and radioactive indication (with streptomycin-s35 in 20,000 U/kg and with 14.2 pCi activity in 1 ml) were used to assess various permeability levels in the histo-hematic barriers of the lungs, liver, kidneys, spleen, myocardium and brain. Toxic regimes were accompanied by a universal increase of vascular walls permeabil ity, conditioned by structural lesions of the histo-hematic barriers. With therapeutic regimes, vascular permeability rose only in the spleen, liver and kidneys, i.e., in.the organs with an Increasing functional ac tivity under hyperbaric oxygenation, and was not accompanied by histostructural changes of the main elements of the histo-hematic barrier. --J. L. S, ' , ; 4828. CCNDER, D. W,, P. C. OLOFFS and Y. S, SZETO. (Pestol. _ Cent., Dep. Biol, Sci,, Simon Fraser Univ., Burnaby 2, B. C., Can.) p GLC separation of heptachlor epoxide oxychlordane, a- and r-chiordane. K. BULL ENVIRON CONTAM TOXICOL 7(1): 33-357 15W,'--GlC [gas----- z liquid chromatography] columns were used to Identify and quantitate organochloride pesticide residues. Such as 3% OV 1, 2% SE 30 plus 6% OF 1, or 2% OV 1 plus 6% OV 210. They did not satisfactorily sep arate the compounds of a-chlordane, y-chlordane oxychlordane and beptachlorepoxide. Gas chromatograph Micro Tck MT 220 with N1-63 electron cepture detector method was employed in this experiment. --J. P. K. 4828. WALTSCHEWA, W. (Forschungsinst. Arbeltsschutz, Beruf- skr,, Blvd. Petko Napetov 34, Sofia, Bulg.), M. SLATEWA and I. M MICHAILOW. Hodenveraenderungen bel weissen Ratten durch chron- ische Verabreichung von Nickelsulfat. (Testicular changes due to long term administration of nickel sulfate in rats.I EXP PATHOL (JENA) 6(3/4): 118-120. lllus. ISM. [Engl. summ.]--Following long-term nickel-sulfate Intoxication in rats, severe lesions in the germ cells particularly in spermiogenesis could be demonstrated. Very few chang es were observed in the livers and kidneys. Nickel sulfate had a se lective noxious effect on testicular jarenchyma.--A, B. M. 4830. BASALAEV, A. V,, A. N. VAZIN and A. G. KOCHETKOV. (S. M, Kirov Cork. Med. Inst., Gorki, USSR.) K patogenezu izmenenii, G voznikayushchikh pri dlitel'nom vozdeistvii vinilkhlonda, [Pathogenesis Z of changes developing due to long-term exposure to the effect of vinyl* chloride.| GIG TR PROF ZAfaOL "16(2): 24-27. lllus. 1972. [Engl, summ,] --Rabbits and rats which inhaled vinylchloride fumes in a max imal permissible concentration (0.03-Q.04 mg/1), underwent a 6-mo. long all-round examination by physiological, biochemical, histomorphological and roentgenodensitometric methods. Changes in the bio electric activity of the hypothalamus, hyperadrenalinemia and function al troubles of the cardiovascular system were disclosed. Development of resorptxve manifestations in the bone tissue was brought out mor phologically and osteoporosis--roentgenologically. An inference is drawn as to a key importance of hypothalamic dysfunction In the patho genesis of the disease, this dysfunction giving rise to neurohumoral and neurovascular troubles leading to the development of dystrophic pro cesses in the bone tissue.--P. L. W. ^7 i i i 4831. COOPER, PHILIP and STEPHEN H. TOUNS. (Dep. Surg., Bronx Veterans Admin. Hosp., Bronx, N, Y, 10463, USA.) Relationship (j between smoking history and complications immediately following sur- 7 gery for duodenal ulcer, MT 0INAI J MED 39(3): 287-29271^3.-- " No evidence is given of an association between smoking and complica tions, nor between smoking and operative mortality, nor between smok ing and days to discharge. The most obvious trend is probably predict able, namely, patients over 50 have more complications and a higher mortality rate than those under 50. In spite of the relatively large number of patients included in this report the smokmg habits, the age distribution, and disease rate in the population studied are quite likely to differ from the general population. Some inconsistencies were found between smoking histones taken on the same patient at different times. This may have resulted from the quality and accuracy of the informa tion given to the examiner by the patient. Few, if any, generalities should be drawn from this research. Results apply only to immediate postoperative findings and do not apply to long-range effects of smeking upon the patient after surgery for duodenal ulcer disease.--E. M. D. 4832. LISITSA, F. M. and L. A. MOTROVA. (Fac. Postgrad. Med., Riga Med. Inst., Riga, USSR.) O klinicheskikh osobennostyakh alkogol'- Z nykh polmevritov. [Clinical traits of alcoholic polyneuritis.! ZHNEV* t C4 U) CS H 3 x tAufu*. 1073) MANAGEMENT IN GEORGIAN ABSTRACT USA RACE I) l QMS 12 15). 1972 7916 ARlYAWANSA K B THE SEVERS CANAL POLLUTION IN C0L0M60S MATERNAL!/ CEYLON PAGE 232-237 BERNUOA 6101 STN RES SPEC PUBL 9. 1971 (PECO. 197)1 79iT VIXLER $ MOODY J . PAVTCM M A STUDY QF THE EFFECTS ON HATER CHEMISTRY BY EFFLUENTS OF THE HOLIOAV INN SEWAGE OUTFALL/ TOBACCO Bay BERMUDA PAGE lSi*m 'I s 79)2 7933 79)9 TORRES J J NANGUM C P (ERECT Of HIGH OXYGEN LEVELS ON NARINE INVERTEBRATES/ ABSTRACT HALIPLANELLA-LUCIAE AURELIA-AURITtA >7702997 Rage Ul CLINE JR COX lit MICH PURITY OXYGEN AERATION OP PROCESS WASTE HATER/ ABSTRACT PAGE 1)2 HALL 4 B JR APPLICATION OP AERO SPACE HASTE RECLANATION TECHNOLOGY TO DOMESTIC HATER RE CYCLING AND SOLID REDUCTION/ ABSTRACT PAGE 1)2 PESS 1 FED EUR BtOCHfN $OC) LETT 2B III. 1972 79)5 OLSNES S PtHL A TREATMENT OP ABRIN AND RtCtN HtTH BETA NfRCAPTO ETHANOL OPPOSITE EFFECTS ON THEIR TOXICITY IN NICE AnO ThEIR ABILITY TO INHIBIT PROTEIN SYNTHESIS IN A CELL-FREE SYSTEM/ ABRUS-PRECATORIUS RICtNUS-CQMMUNlS PAGE 96-50 PSYCHOTHCR PSYCHOSON 21 11-4) 1972 7916 7919 7920 CHERTOR L BOURGtGNON 0 VEIL C PSYCHOLOGICAL EDUCATION OF PHYSICIANS IN INOUSTRIAL MEDICINE/ HUMAN PAGE 195*191 OEIASNERIE * HYSTERICAL CONDUCT IN HALE INDUSTRIAL PERSONNEL/ HUNAN TRANQUILIZER PAGE 199*152 6ELLY R PSYCHO THERAPY IN THE MILITARY ENVIRONMENT/ HUMAN AGGAESSIVITY PA6$/ 153*155 AGING HUM DEV 3 I))* I9T2 (RECO* 197)) 7921 LINN M W LINN B $ GREENMALO S R THE ALCOHOLIC PATIENT IN THE NURSING HOME/ CIRRHOSIS BRAIN DISEASE PAGE 273-277 .******'******************************- VA J SCI 2) ()|, 1972 7922 7923 7924 7925 T926 T92T 7921 7929 7930 7931 ELDER J M JR RCNEAU R B JR SIMPSON T U INFLUENCE OF SOILS ON CONTAMINATION OP A WATERSHED BY SEPTIC POLLUTANTS/ ABSTRACT DOMESTIC HASTES PICES CQLIFQRM COUNTS PAGE 100 RENEAU A B JR PETTAY 0 E THE MOVEMENT OP SEPTIC TANK EFFLUENT IN SELECTED COASTAL PLAIN SOILS OF VIRGINIA/ ABSTRACT USA COLIPORM BACTERIA PAGE 102 ANDERSON G THE EFFECTS OF OIL ON THE GILL FILTRATION RATE OF MYA-ARENARIA/ ABSTRACT **002059 PAGE 108 GREGG C BENFttLO f TOXICITY OP ZINC SULFATE TO ISONVCmM-SAOLFRI EPMEMEROPTERA ISONYCHtlOAE FROM 2 STREAMS/ ABSTRACT NYMPHS HATER CHEMISTRY SIZE >TT))020 PAGE 110 , HASTINGSH S KIMBROUGH T 0 LLEHELLTN G C 0*R(AR C| RCA F H THE EFFECT of di METHYL FORNAMIOE ON MERIONES-UNGUICULATUS/ ABSTRACT N1L0 CARCINOGEN LIVER OISOROER *66122 FACE Ul LIVY G F ARE R L SPENCER R S POHEIL C WOODRUFF L S FENNEMA R ashhorth K AN INTEGRATED STUDY OF THE NORTHWEST RIVER AND ITS WATERSHED/ ABSTRACT FLORA FAUNA FOREST TYPES PHOSPHATES CHLORIOE NITRATES ALKALINITY HARONESS PESTICIDE RESIDUES GEOLOGY >14265492 16B87004 *14797518 PAGE 112 LYNCH M P WEBB K L THE USE OF SCRUM CONSTITUENTS OF THf BLUE CRAB CALLINECTE$*SAPIDUS AS INDICATORS OF PHYSIOLOGICAL STRESS/ ABSTRACT REO TIDE THERMAL STRESS CHLORIDE ION PROTEIN GLUCOSE PAGE It) MORGAN E L SPARKS I GARVIN J A CAIRNS J JR 24 48 ANO 94 HOUR MEDIAN LETHAL CONCENTRATION FOR BtUEGILL LEPQMTS-MACROCHIRUS EXPOSED TO hEXAChLORCPmENE/ ABSTRACT >70304 PAGE lt4 PYLES A LLEWELLYN G C 0*R(AR C E RCA f H The EFFECT op chronic EXPOSURE OP CALCtUW CYCLAMATE ON HER(0NE5-UNGU!CUL ATuS/ ABSTRACT URINARY BLADDER KIDNEY LIVER RRE CARCINOGENIC ACT IVITY *139040 PAGE 113 SCHEELF R A LLEWELLYN G C O'RfAR C f CAOIE T THE OCCURRENCE OF AFLA TOXIN IN SAMPLES OF PEANUTS PROM VIRGINIA/ ABSTRACT USA PAGE 116 CURR SCI (BANGALORE) 91 191, 1972 7914 RAO A T iCHARJYQ l N tYER P R R MEMO SIOEROSIS |N A MUSCOVY DUCK CAIRInA-mOSCHATA/ NOTE FUNGAL PEEO TOXINS LIVER MONEY PAGE 342 N ENGL J NfP 2IT 122), 1972 T93T JAEGER R J RUBIN R J MIGRATION OP A PHTHALATE ESTER PLASTICIZER FROM PQlV VINYL CHLORIDE BLOOD BAGS INTO STORED HUNAN BLO00 AND ITS LOCALIZATION IN HUMAN TISSUES/ OQG PAGE 1U4*1UB **************#****** U S FOR SERV RES NOTE NE 140, 1971 (RECO 1972) T9)B LEONARD R E HERRINGTON L P NOISE ABATEMENT IN A PINE PLANTATION/ SOUND ABSORPTION PAGE 1*6 VET RfC 91 (24), 1972 (RECO. 1973) T939 HEARD T H ADDITIVES IN FEED AND THE EUROPEAN ECONOMIC COMMUNtTY/ HUMAN PAGE 453-454 CALIF AIR DUAL DATA 4 (ll. 19T2 7940 CALIF AIR RfSOUR BOARO CALIFORNIA AIR DUAL ITT OATA JANUARY THROUGH MARCH 1977/ USA OXIDANTS CARBON MON OXIDE SULFUR DI OXtDC NITRIC OXIOE NITROGEN Ot OXIDE HYDRO CARBONS LEAO PARTICULATE MATTER *101024)9 *7446091 *74)9921 *10102440 *4)0060 PAGE 1-49 FED PROC 32 (3 PART 1). 197) 7941 7442 794) 7944 7943 KONIJN A N GUGGENHEIM K CHARACTER!2AT ION AND NQOE OF ACTION OF A GOITROGEN PRESENT |N SOYBEANS/ ABSTRACT RAT OLIGO PEPTIOE SUGAR IOOINE INHIBITION PAGE 216 BERT M H NAFARACHIS!B A NAHAR H H SNOCYfNBOS G H ANOERS0N D L TOXICITY OF SOME SATURATED AND UNSATURATED OIETARt HYDRO carbons/ ABSTRACT HUNAN MOUSE BEEF FAT IRRADIATION PAGE 223 TERHAAR C J KRASAVAGE M J ASTllL B 0 FASSETT 0 W R0U0A6USM R L WOLF G L MORGARPIOGE K E MONO TERTIARY BUTYL HYDRO QUINPNE T ITS SAFETY EVALUATION tN AM HALS/ ABSTRACT RAT MOUSE GUtNEA-PIG OOG FOOD GRAOE ANTI OXtSANT *1448330 PAGE 223 PFUOERER P FRANCIS A A DOHERTY 0 G THE EFFECT OP PHTHALATE ESTERS ON THE HEART RATE OF THf GOIOPISM/ ABSTRACT BENZYLBUTYL PHTHALATE Ot OCTTL PHTHALATE ATROPINE CAROIO VASC-ORUG *117840 *|36T PAGE 224 ZEBALLOS G A RASULtO J BOSCO C MUNOZ C SALINAS-ZEBAUOS M E O LI 2523 681 [October, 1973] rence in children with Pb intoxication. Acute encephalopathy may overshadow its recognition, but chronic exposure to Pb may produce changes in peripheral nerve fibers that result in altered conduction characteristics. In this study 24 Boston, Massachusetts, USA, child ren with known plumbism were found to have reduced mean motor nerve conduction velocities as comparea witn normal children* This finding mav provide a valuable test for discovering minimal peripheral neuro toxic effects of chronic exposure to Pb ingestion. 9477. THOMSON, MAURICE L. (TUC Centen, Inst. Occup, Health, 0 Lond, Sch, Hvg, and Trop. Med., Keppel St. Gower St,, London WC1E 2 7HT, Engl., UK.) and DEMETRI PAVIA. Long-term tobacco smoking and mucociliary clearance: From the human lung in health and res piratory impairment? ARCH ENVIRON HEALTH 26(2); 86-89. IIluS. 1973.--The rate of mucociliary clearance was estimated from the re moval of inhaled radioactive particles in 79 elderly subjects of whom 50 had healthy lungs and 29 had respiratory impairment that was ob structive in 13 and restrictive in 16. The 29 impaired subjects had on the average a taster clearance than the normal group, a difference that almost approached significance (5$ level) at 6 hr after the inhala tion of the aerosol. The obstructed subjects showed the fastest clear ance with the restricted group intermediate between these and the nor mal group. No significant difference was found between the rates of clearance of smokers, nonsmokers and ex-smokers in either healthy or diseased groups. 9478. PEKKANEN, TIMO J. and KALEVI SALMINEN. (Dep, Food MHvg., Coll, Vet. Med., Helsinki, Finl,) Inductive effects of methvl mercury on the- hepatic microsomes of mice, ACTA PHARMACOL TOXICOL 32(3 4): 289-293. 1973.--Male NMRI mice [36] weighing about 17 g each were divided into groups of 12 animals. Groups 1 and 2 were treated once i.p, with methyl mercury nitrate. Group 1 received 0.3 mg Hg kg and group 2 10 mg Hg/kg in 0.5 ml water; the 3rd group, which was kept as control, was treated i.p. with 0,5 ml water. After 7 days all the mice were sacrificed. The mean total liver protein was significantly decreased in group 2. The mean liver microsomal pro tein was significantly (P<0,01) increased in groups 1 (P<0.01) and 2 (P<0.02) as compared to the controls. The mean cytochrome P-450 concentration of the liver microsomes was also significantly increased in groups 1 (P<0.001) and 2 (P<0.01) as compared to the controls and in group 1 (P<f0.01) as compared to group 2. The mean liver micro somal NADPH-cytochrome c-reductase activity was significantly greater in group 2 (P<0.001) and in group 1 (P<0,01) than in the con trols. The mean NADPH-cytochrome c-reductase activity of group 2 was also significantly greater than the mean activity in group 1 (P< 0.02), 9479. HARRIS, A. BASIL (Dep. Neurol. Surg.( Umv. Wash. Sen. M Med., Seattle, Wash. 98195, USA.) Ultrastructure and histochemistry of alumina m cortex. EXPNEUROC 38(1); 33-63. UluS. 1973.'--" ^" After injection of the epileptogenic compound alumina, into the cortex of 2 adult monkeys (macaca mulatta). positive histochemical reactions occur in the lesion border immediately and later in macrophages of the granuloma, blood vessels and cortex. Perivascular alumina de posits may appear intraneuronally but are overlying instead. Mod erately electron-opaque alumina crystals ^15 A wide by 500 A long increase their densities by adhering osmiophilic serum and cell products. Endocytosed crystals are seen in monocytes, fibroblasts and astrocytes, but not in polymorphonuclear leukocytes or neurons. Macrophage secondary lysosomes, complex cytosegresomes and dense and light vacuoles contain crystals at all stages from 1 day to 5.5 yr after injection. Some crystals appear entangled in filaments and microtubules without definite limiting membranes. Intracellular alumina is associated with increased cytoplasmic filaments, multivesicular bodies, lysomes, free ribosomes, autophagosomes and multiple vacuoles. Intracellular digestive processes may slowly degrade crystals into soluble compounds reflected by increased filaments in astrocytes and macrophages. These changes may indicate the sites of importance in the genesis of this type of epilepsy. 9480.. PELLING, D. (Br. Ind, Biol. Res. Assoc., Woodmansterne Road, Carshalton,Surrey, Engl., UK.), M. SHARRATT and JOAN HARDY. D The safety testing of medical plastics: I. An assessment of methods 2 FOOD COSMET TOXICOL 11(1): 69-73. Ulus. 1973. [Fr. and Ger,-- 8umm,]--The toxicity of a variety of plastics medical devices used in medicine and of a number of polyvinyl chloride (PVQ samples of known constitution was evaluated by tissue culture techniques, im plantation tests m rabbit muscle and rat Subcutaneous tissue, and examination of the systemic effects of administering extracts of the plastics to rats and mice. PVC samples containing known concentra tions of an organotin compound were used as positive controls. None of the test plastics exhibited toxicity as high as that of the positive control plastics. The tissue culture technique was the most sensitive method used and toxic effects were detected with a few of the test plastics. Implantation in rabbit sacropmahs muscle for 7 days was the most Sensitive of the implant systems tested and the results showed a good correlation with tissue culture. The systemic tests un extracts failed to demonstrate toxicity, even with the positive control A/PPP 2 <#/o /?73 & 9477-9484 plastics. In view of the high sensitivity of tissue culture, positive results should not necessarily indicate rejection of a plastics material for medical use. In such a situation, additional experimental evidence was required. 9481. WINDELER, A. S. Jr. (Exp. Dent. Sect., U. S. Air Force Sch. Aerosp. Med., Brooks Air Force Base, Tex. 78235, USA.) Deter- p mination of mercury in parotid fluid, J DENT RES 52(1): 19-22. " " tyl Illus. 1973.--Analysis of Hg in parotid fluid involves aeration-reduction of Hg and measurement of spectrophotometric absorption of the evolved Hg at 2.537 A. This procedure is quick, sensitive, and accur ate and does not require the extraction of the element from the sample before analysis. The s d for the method was 0.479 for samples of parotid fluid containing 6-31 ng Hg/ml. 9482. KACEW, SAM and RADHEY L. SINGHAL. (Dep. Pharmacol., Umv. Ottawa, Fac. Med., Ottawa, Otit., Can. KIN 6N5.) Adaptive res- p ponse of hepatic carbohydrate metabolism to oral adminisiratTon~of~ 2 P.P^-lq l,*tnchloro-2.2-bIs (p-chlorophenvl) ethane in rats^ bK>CHEM PHARMACOL 22(1): 47-57. Illus.!973.--The effects of an acute dose of p,p'-l,l,l-trichloro-2,2-biS (p-chlorophenyl)ethane (p.p'-DDT) were studied on the activities of pyruvate carboxylase, phosphoenolpyruvate carboxykmase, fructose 1,6-diphosphatase and glucose 6-phosphatase in rat liver. Administration of p,p'-DDT (600 mg/kg, (orally)) produced 2-to 2.5-fold stimulation of these key gluconeogenic enzymes m 5 hr; statistically significant increases could be detected at 1 hr. Blood glucose increased as early as 0.5 hr, attained peak values at 1 hr, and declined to reach control levels u\ 3-5 hr. Hepatic glycogen decreased gradually to 47'/( of the control values in 1 hr and was restored by 3 hr following treatment with this insecticide. Administration of p.p'-DDT to adrenalectonuzed rats produced similar changes in blood glucose and hepatic glycogen, suggesting that the insecticide-induced hyperglycemia and glycogenotysis may not be mediated by a release of catecholamines from the adrenals. Dose-response studies revealed that 100 mg/kg of p,p'-DDT was the minimal amount necessary to induce statistically significant increases in the activities of hepatic pyruvate carboxylase, phospho enolpyruvate carboxykmase, fructose 1,6-diphosphatase and glucose 6-phosphatase, Maximal stimulation of the 4 key gluconeogenic enzymes was seen generally at 5 hr when rats were treated with a 400-600 m^kg dose of p,p'-DDT. Daily administration of small du^es of p,p'-DDT (5 or 25 mg/kg) for 45 days also resulted m significant enhancement in the activities of various hepatic gluconeogenic enzymes. Actinomycin D, cycloheximide or ethionine failed to affect the basal levels of either of these hepatic enzymes but effectively reduced the insecticide-induced increases in various enzyme activities. Treat ment of adrenalectomized rats with p,p'-DDT enhanced various hepatic enzymes to a degree similar to that observed in intact animals. Ad ministration of triamcinolone to p,p'-DDT-treated adrenalectomized rats did not potentiate the action of the insecticide on any of the gluconeogenic enzymes examined. Treatment with p.p'-DDT apparent!* produces marked increases in the quariet of key, rate-limiting gluconeogenic enzymes in hepatic tissue which are not mediated through a release of corticosteroids from adrenal glands. 9483. BUDREAU, CLAIRE H. (Dep. Anat., Health Sci. Cent., Umv. West. Ont., London, Ont., Can.) and RODERICK P. SINGH. p Transplacental passage of demeton. in CF-1 mice. ARCH ENVIRON 7 HEALTH 36(3): 161-1637 Illus.T973,_--The transplacental passage of demeton labeled with radioactive phosphorus (32p) jn pregnant CF-I mice was followed autoradiographically in frozen sections of fetal and placental tissues. The organuphosphorus insecticide was injected i.p, on the 14th day of gestation at a dose of 5 mg/kg. Pla cental tissue, fetal muscle, and osteogenic mesenchyma were heavih labeled within 20 min., the radioactivity decreasing with longer periods of treatment. Liver incorporated demeton maximally between 1 and 2 hr, The compound appeared to be rapidly metabolized because fetal tissues showed only trace activity after 3 hr. 9484. MC LAUGHLIN. MARTHA (E. I. du Pont de Nemuurs Co , Haskell Lab. Toxicol, and Ind, Med., Elkton Road, Newark, Del, M 19711, USA.) and GORDON J. STOPPS. Smoking and lead. aKCH O ENVIRON HEALTH 26(3): 131-136. 1B73.--The smoking habits ul U over 4000 Du Pont employees were compared with their urine and 2 blood Pb levels. The mean urine Pb levels were found tu be 27 1 liter fur nonsmokers, 28.6^g/liter for cigarette smokers, and 29,0/aft/hter for pipe and/or cigar smokers, Moan blood Pb values were 19,1 pg/100 ml, I9.9p.g/100 ml, and 17.3/ig/lQO ml, respective!,, fur the 3 groups. The data were submitted to a multiple regression analysis to determine if the differences in groups were associated with smoking habits or a reflection of other variables. No evidence was found to indicate a significant effect of smoking on blood Pb levels The iiJluenec-of smoking on urine Pb levels, while statistically sig nificant, was very small compared with the local variability of the cLita and pi obably of no biolugical significance* O LI 2524 r! 693 [October. 1973] 9596. DRUYAN, E. A. (F. F. Erisman Mosc, Res. Inst. Hyg., A Moscow, USSR.) Spektrofotometricheskoe opredelenie trikrezilfosfata D i dibutilftaiata pri lkh sovmestnom prisutstvli v vozdukhe. [Spedro2 photometric determination of trlcresvlphosphate and dibutylphthalate jointly present In air.1 "GIG SA^IT- 37(2): 100- 102. 1972.--A method was developed for determining levels of toxic, volatile plasti cizers commonlv used in flooring materials. Polymeric materials based on polwinvl chloride (PVC) and celloxylin resins often contain tricresvlphosphate (TCP) and dibutylphthalate (DBP) as plasticizers. To determine the concentration of each substance when both were present, alcoholic solutions of TCP and DBP at concentrations of 10 and 30 . >: m 1 were measured spectrophotometrically at 2 wave lengths: TCP absorbs intensely at 215 nm and DBP, at 225 nm. A calibration curve was constructed. An alternative method involves measurements at 220 and 225 nm. Concentrations are calculated by the solution of 2 simultaneous Firordt equations. Experiments were performed on linoleum samples 100 cm2, at 20 and 40, kept in conical flasks. After 24 hr, air samples were withdrawn at a rate of 0.5.1/miu into a sorbent charged with ethanol (with cooling). Optical density was determined at 215, 220 and 225 nm and TCP and DBP concentrations deter mined mathematically. The error of determination of TCP or DBP in the mixtures did not exceed 20%, which was satisfactory considering the low concentrations involved,--M. D, S. 9597. GRANGER, JEAN-MAURICE. (Inst. UrbaniBme, Umv. A Montreal, C. P, 6128, Montreal 101, Que., Can.) Computer mapping an an aid in air pollution studies: Montreal region study. SARRACENLA 15. 43-83. Ulus. 1972. [Fr. summ.)--This article discusses: the appropriate selection of a set of local factors chosen as useful indicators, given the type of urban pollution; and the optimal spatial distribution of the required data over either the urban or rural zones of the region. The technique is applied to the Montreal, Quebec (Canada) region and allows an almost instant appraisal of the intensity of atmospheric pollution.--D. T. S. 9598. ESPEY, W, H,, Jr. and G. H. WARD Jr. (TRACOR, Inc., IN 6590 Tracor Lane, Austin, Tex, 78721, USA.) Estuarine water Quality models. WATER RES 6(10): 117-1131. Illus. 1972.--The results are reviewed of a study (Ward and Espey) undertaken by the Environ mental Protection Agency to evaluate the use of models--mathematical, hydraulic, and electrical analog--for simulating pollution processes in estuaries and predicting results of proposed pollution control actions.--D. T. S. 9599. SALYAMON, G. S. and N. A. PETROVA. Opredelenie mikroq grammovykh kolichestv polietilenaminov v vode. [Determination of W micrograin quantities of polyethylene polvamines in water.1 GIG 2 SANIT 37(5): 59-63, 1972j--The sensitivity of colorimetric analysis of polyamines, based on interaction with eosin and copper sulfate, increases with a decrease in pH of the medium. By adding citrate buffer solution, pH 2.5-2.7, it reaches 0.006 mg/1 for polyethyleneimines (PEI) and 0.02-0,2 mg/1 for polyethylene polyamines (PEPA). The Cu-eosln reagent permits analysis of high-molecular PEPA in the presence of iow-molecular PEPA. Total high-molecular ethyleneamines and low-molecular amines can be determined colorimetrlcally using p-nitrodiazobenaene. PEPA can be analyzed In the presence of PEI using the known colorimetric reaction for secondary amines with 1,2nanhthoqumone-4-sodlum sulfonate. The sensitivity is high (0.02 mg/1). --M, D. S. 9600. FILIPPOV, A. P,, V. K. KOMLEV and V. V. MAL'TSEV. A (All-Union Res. Inst. New Constr. Mater., Moscow, USSR.) Metodika O gazo-khromatograficheskogo lssledovaniya letuchikh veshchestv, 2 vydelyaemykh v vozdukh pollmernyml stroitel'nymi materialami na osnove polivinilkhlorida. fGas-chromatographic analysis of volatile substances emitted into the air bv construction polymers with a poly vinylchloride base.1 GIG SANIT 37(6): 67-68/ lilus. 1972,--Analysis was made after a preliminary concentration. This method can be used for quantitative and qualitative comparisons of sanitary-hygienic con ditions.--M. D. S. 9601. MADEYSKI, A, (Inst. Balneo- Climatol., Poznan, Pol.) O A nlektorych problemach zabezpleczenia optymalnego srodowlska w uzT drowiskach. [Some problems Involved In optimal protection of the w environment In spas.l BALNEOL POL 16(3/4): 241-246. 197l(-recd. 1972^--HeaUh resorts should be away from urban agglomerations. The natural capacity of the environment should not be overreached. Industrial plants should be erected far away from these places. Noise, water and air pollution should be avoided. -- (Courtesy NSF PL 83-480). F. W. 9602. BRODNIEWICZ, A- and B, JUROS. (Acad. Phys. Educ., T Warsaw, Pol.) Aspekty higiemczne ochrony uzdrowisk przed halasem. [Hygienic aspects of spa protecTion'ag;fl.nst noise.1 BALNEQL POL 16(3/4JT223-239. Illus. 1971[recd. 1972].--The most important aspects of the problem (next to the legal aspect) Is the planning of highways, streets, town quarters, industrial centers and airports. ? 9596-9607 while taking into account the factor of quietness. Calm has a bene ficial effect In the treatment of many diseases. --(Courtesy NSF PL 83-480), 9603. KROTKOV, F. G. Nauchno-technicheskii progress, vneshnyaya sreda i chelovek, [Scientific-technical progress, the environment ^ and man.) GIG SANIT 37(6): 3-9! 1972.--In this literary report, g the scientific-technical progress of Soviet industry, medicine, etc., j is described. Aspects of the human environment, e.g., air, HgO, soil, yy and noise pollutions, their effects on man and protective and preventive measures to be undertaken, are discussed. General aspects of studies conducted in the USA and USSR are illustrated. Concern is expressed over environmental changes produced by scientific-technical progress and a request Is made to utilize scientific-technical knowledge to remove harmful materials from man's environment,--M. D. S. 9604. LANGE, H, J. and R, REITER. \n^>t. Med. Datenverarb. Ges. Strahlen Utnweltforach., Tech. Univ. Muench,, Arabellast. 4/1, o 8 Muenchen 61, West Ger.) Datenverdichtung bei der Auswertung x multlvariater epidemiologischer Studien, [Data reduction in the evaluation of multivariate epidemiological studies.1 METHODS INF MED 11(4); 253-257. 1972. [Engl, summ.]--The problems of statis tical analysis in an epidemiological cross-sectional study of 13,000 workers with 300 qualitative and quantitative characteristics per case were discussed, with the objective of determining the significance of chronic inhalable noxae, present at the place of work, for chronic bronchitis and pulmonary emphysema. Models for estimation of dust exposure in previous years (the causative factor), for reduction of the number of symptom-groups and elimination of modifying factors were presented, A comprehensive index was computed, in analogy to the Staubsummenwert (cumulative dust exposure index) used in the coal mining industry of the Federal Republic of Germany. The decision- tree method was used to reduce the large number of qualitative and quantitative symptom-groups. Modifying factors were considered by eliminating individual cases, by constructing sub-groups and by reference to nominal values. 9605. ASTRAND, IRMA, P. FUGELLI, C. G. KARLSSON, K. RODAHL (Inst, Work Physiol,, Gydas vel 8, Oslo 3, Norway.) and Z. VOKAC, Energy output and work stress in coastal fishing, SCAND J CUN LAB INVEST 31(l): 105-113. Illus. 1973.--Energy expendi ture in 14 fishermen engaged In fishing was determined by direct measurement of O2 uptake and by indirect assessment based on continuous recording of the heart rate. Urinary excretion of catecho lamines was assayed as an index of stress response. The average energy expenditure during all activities on board for the whole work day amounted to the equivalent of about 1 liter O2 uptake per min, corresponding to about 39% of the fishermen's maximal aerobic power, with peaks up to 80%. On the average, about a 10-fold increase in epinephrine and a 4-fold increase in norepinephrine excretion were observed during work as compared to resting night values. q 9606. HARSTELA, PERTTL (Inst. For. Fenn., Helsinki, Finl.) Puunkorjuumenetelmien ergonominen kehitys ja eraat tyontekijaan q kohdistuvat fyysiset vaikutukset. fThe ergonomic development of tlmberT harvesting work methods and some physical effects on workers. I FOLIA FOR (HELSINKI) 131. 1-22. Ulus. 1971 [reed. 1972], [Engl, summ.]--A literature review traces the ergonomic development in Finland in the late 1960s and early 1970s. It examines the development of work methods for the power saw from the point of view of physio logical stress and the time the worker is exposed to vibration. Ways were sought to change the work methods to reduce their untoward effects on the worker. Forest work methods were developed by simplifying labor-intensive methods and by increasing mechanization. Mechanization changes ergonomic problems from the consequences of the use of muscular energy to the effects caused by the use of nervous energy and psychic stress and the effects caused by the machines such as vibration, swaying and noise and the working conditions of the machine operator. Labor-intensive methods were simplified by in creasing the length of timber, which Increased the stress of bunching, and by simplifying bucking and limbing, which increases the time of exposure to vibration since it necessitates limbing by power saw. The omission of measuring in the light phase of work increased the intensity of the work. Felling alone for processors requires less muscular energy expenditure than the traditional methods of work, but the labor output is smaller than in felling In connection with other work. Working in deep snow is an exception where felling alone is heavy work as it requires a lot of movement. Methods can be developed that are ergo nomically better, e.g., by leaving bunching work to machines and by phasing the bunching into small lots. However, reducing the bunching work will add to the disadvantages of power sawing. Reducing the vibration of the power saw, adequate breaks, shortening the daily sawing time and using a correct sawing technique seem to be the only current methods for reducing the risk of vibration damage.--J. E, F, 9607. REINHOLD, R., K, RASCHE and W. WERNER. (Bezirksmsp. Gesundheitschuta Betr., Kurt-Berthel Stras&e 39, 90 Karl-MarxSiiidt, East Ger.) Hochfrequenter Laerm und seine Wirkung auf den O T OLI 2525 aiwr-iiriirty^ 29 (Jan., 1973] /O 285-295 ^S. -ank^ 7m most 1 ititae of 1. rosu i bronThe bably kely .. UK.) :ROSP 'logy ich xaoct ecord* al cov ing eat ?re^nceo* cirZXpQfW! ihromi* alts islattd KSIKOL Is, in* ilOfis in 32 . Za<r4 Inves- 3. posed dimeovr after albumin M. hlkh, irJune* . ICVT j 0. i 2DSTVA i worker* * ie there : - or I ei- , lrbanee* tabolisk cytoaii' utensioe , i**rvd- , can vleasur* 3 in salon*!' igoi* * ational l! Basin. j f <5Jd ; 10.54. conlo* lopme^ e ab- ther* .n mo*l [ 285. PODLUZHNYI, P. A., and T. V. YASHCHAK, VUyame malykb [Characteristics of electrocardiographic changes in patients with vinvl A kontaentratsli krksltelya semistogo chiatogolubogo "K" na organism chlonde^poisoningj GIG TR PROF ZABOL 14(8): 54-56. 1970,-- ECO * jhivotnykh (l*e soobahehenie). [The effect of low concentrations of the studies of 50 male and 43 female workers suffering chronic vinyl chloride 0 rive sulfur pure blue K on the animal bodv: 1.1 TK PERM MED INST poisoning revealed cardiovascular disturbances manifested as changes X 82: i44-l5<>.I9W.'Translated from REF ZH OTD VYP FARMAKOL in rhythm, conductance and repolarization processes and an increase M KHIMIOTER SREDSTVA TOKSIKOL, 1970, No. 10.54.622.--To set stan in systolic index. ECG data should be used to determine the condition dards for the concentration in the air at working places of an aerosol of the heart when evaluating the degree of vinyl chloride pgisoning in a of the dye sulfur pure blue K, rats were exposed for 4 mo. by inhalation patient.-*C, P. to the aerosol at concentrations of 4 and 10 mg/m3. At the latter con centration 1 mo, of exposure caused failure to gain weight, hypoproteinemia and a tendency to hypoalbuminemia. All the changes disappeared after exposure stopped. At 4 mg/m3 no changes were caused in the animals during the entire experimental period. No deviations were found in the blood picture or cholinesterase activity. At 4 mg/ra3 the aerosol had no appreciable action on the bodies of experimental animals under conditions of prolonged inhalation.--S. T. ~ 292. 11/INA, V. A., and T. A. KOCHETKOVA. (Inst. Ind. Hyg. Qc^ cup. Dis., Acad. Med. Sci. USSR, Moscow, USSR.) Eksperimental'nyi pnevmoskleroz pri vdykhamt aerozolei magnievolitievykh splavov. [ExM perimentel pneumosclerosisfrominhalatlon of magnesium-lithium alloy X aerosols.1 GIG TR PROF ZABOL 14121: 17-21. tb70-(Enel, sum.1-- When inhaled, Mg-Li alloys have an irritating action on the mucosa of the upper respiratory tract and pulmonary tissue and cause a number of changes in the respiratory organa. These include moderate catarrhal 28$. BELOVA, S. F. (Inst. Ind. Hyg. Occup. Dis., Acad. Med. Set. . USSR, Moscow, USSR.) Klinika porazhenil glaz, voznikayushchikh pri " vozdeistvii soedinenll sery, (Clinical picture of eye lesions occurring tracheitis, bronchitis, interstitial pneumonia, diffuse sclerosis and em physema of the lungs. The extent of the pathological process becomes greater as the Lt proportion in the alloy increases.--C. M. M. G under the effect of sulfur compounds. I KLfN MED 4813): 96-92.1970, M [Engl, sum.]--The vision of 61 workers in the spinning shop of a factory q producing artificial fibers was investigated. HgS and C52 penetrated the air of the shop in a quantity exceeding the maximally permissible concentrations. Occupational eye diseases accompanied by inflammatory manifestations of the anterior region of the eye, ocular nerve distur bances and a reduction of the working capacity occurred in some cases. --C. M. M. 293. ZHDANEEVA, G. S. O rentgenologlcheskikh izmeneniyakh v A legkikh pri intoksikatsli karbonil-nikelem v ostrom i otdalennom period ic, akh. (X-rav changes in the lungs with nickel carbonyl poisoning in the J" acute phase and later.l KAZAN MED ZH 1. 47-50. mb. Translated X from REF ZH OTD VYP FARMAKOL KHIMIOTER SREDSTVA TOKSIKOL. 1970, No. 7.54.769.--In 5 men and 2 women (of whom 6 were 21-31 yr old and 1, 52) who had undergone acute poisoning from inhaling nickel 2S7. KUZINA, V. F. (Inst. Ind. Hyg. Occup. Dis., Gori. USSR.) 2 Materialy po otsenke tokslcheskikh ivoistv smazoehno-okhlazhdayshchei' ihldkostl NGL-205. (Data related to the evaluation of the toxic properties of NGL-205. a lubricating and cooling fluid. I GIG TR PROF ZABOL 14(3): 57-59. 1970.--The effects of N<jL-205, an oil solution of sodium sulfonate and passtvators (water soluble corrosion inhibitors; sodium nitrate, trisodium phosphate and soda), were studied in rats. Acute Inhalation poisoning (single 4 hr exposure at 200 mg/m3) resulted in Increased gamma-globulin and albumin In blood plasma. Long-term Inhalation (4 hr dally doses for 6 mo. at 42 mg/m3) produced chronic Intoxication characterized by retarded weight gain, reduced 02 uptake, disruption of hippuric acid synthesis upon Introduction of sodium benzoate and alteration of the ratio of protein fractions in blood serum. MetHb and Heinz bodies also appeared during the 1st months. Animals exposed to concentrations of 3-5 mg/m3 showed no effects. Maximum permissi ble concentration of 3 mg/m3 is therefore recommended. Application 5 and 10% emulsions of NGL-205 to the skin caused local irritation. A 2% emulsion had no affect.--C. F. carbonyl, observations were made of the organs of the thorax for 1-12 yr. On the 2nd or 3rd day after the poisoning, a high position of the diaphragm was noted. The respiratory movements of the diaphragm were not determined or were limited. There was reduced air content of the pulmonary field. Two patients showed intensification and vaguesness of the lung picture and of the roots of the lungs and the remainder also showed bilateral foci. Retrograde development at the X-ray changes began on the 7th-12th days. The outcome of the poisoning was favorable in all the young people. Dynamic observations for 10-12 yr showed that they were completely recovered. Regression of the X-ray changes in the older patient was noted until the 29th day. The position and respira tory movements of the diaphragm were restored in 3 mo. The picture of the lungs and roots became as they originally were in 2 yr after the poisoning. After 7 yr the patient developed pneumosclerosis, cardio sclerosis and stage 1 respiratory insufficiency. Nickel carbonyl poison ing is probably not the determining factor in the growth of the sclerotic process. Its principal toxic effect is a disturbance of the lung capil laries and arterioles. Acute poisoning in healthy persons does not leave after effects.--5. T. 288. RYZHDC, L. A. (Inst. Ind. Hyg. Occup. Dis., Leningrad, USSR.) A Clglenicheakaya kharskteristlks protsessa proizvodstva fol'girovannogo 294. OSETROVA, V. I. Sostoyanie zdorov'ya rabochlkh tsekha floto- q getinaksa. (Hygienic characterization of foliated hetinax production.) q fabriki Bereznlkovskogb kaliinogo kombinata po dannym perlodicheskikh GIG TR PROF ZABOL l4(S): 12-1571970. [Engl. sum.J--Hygienic con- meditsinskikh osmotrov. (The health of workers at the flotation compound " ditiona of work and health status of workers engaged in the production ' plant of the Berezovskii Potassium Combine, according to data from T of hetinax and glass textollte were studied. Adverse factors, such as Z periodic physical examinations. I TR PERM MED INST 82: 88-90. pollution of environmental air with acetone, phenol, cresol, formaldehyde 1970. Translated from REF ZH OTD VYP FARMAKOL KHIMIOTER and ammonia and high air temperature were described. Some workers SREDSTVA TOKSIKOL, 1970, No. 10.54.757.--Of 137 workers examined demonstrated functional changes In the CNS and cardiovascular system. 70% were women, SO had worked less than 10 yr and 77 more in the flota To remedy the situation, corresponding health measures were elaborated. tion compound plant of the potassium combine. The potentially occupa --C. M. M. tionally harmful products there consisted at higher aliphatic amines of fatty acids at concentrations tens of times the maximum allowable with 289. ANOKHIN, L. V., and T. K. MAKSIMOVA. (Dep. Pathol. Anat.. 0 Voronezh Med. Inst., Voronezh, USSR.) Deistvte etilbenzola na verkhnei G Jykhatel'nye putt i mery profllaktiki pri rabote s mm. (Effect of ethvl 7 benzol on the upper respiratory tract and preventive measures during L itsuse.l ZH USHN NO flORL BOLEZ 30151: 4-9. lS'M. lEnel. sum.1 a relative humidity of up to 96% and temperature in the plant of up to 30*C. The patients complained mostly of headache. Of those examined, 50% showed moderate tachycardia, dulling of heart tones, labile blood pressure and functional CNS disorders. Tenderness In the right sub costal area was noted in 18 patients and urobilin was found in the urine --During the prolonged effect of ethyl benzol vapor (0.01-0.03 mg/1) alterations chiefly of an atrophic nature, develop in the upper respiratory tract of the workers. In experimental animals ethyl benzol vapor (0,01 of most of those examined. Equipment operators exposed most to amines showed an increase m the number of reticulocytes and thrombocytopenia. --S. T. `ig/l) causes changes in the mucous membrane of the upper respiratory tract which are characteristic of catarrhal inflammation. At a concentra tion of t.o mg/1, in addition to the chronic inflammation, manifestations 295. MOZAN, C., A. LACQUANITI, and L. PETTINATI. (1st. Med. Q Lav., Turin, Italy.) Evaluation du risque induit par les toxiques mdus- of atrophy of the mucous membrane with fibrosis of the submucosal layer A triels. (Evaluation of the harzards created by industrial toxins.1 ARCH xlso appear, preventive measures are recommended during the use of A MAL PROF MED TRAV SEC SOC 31(3): 141-146. 1970.--The means Uifl benzol.--C. M. M. Z of evaluating the atmospheric hazard created by industrial toxins that are currently practiced appear to be unsatisfactory and open to criticism. 290. BATSURA. Y, D. (Inst. Ind. Hyg. Occup. Dis., Acad. Med. Sci. M USSR, Moscow, USSR.) Elektronnomikroskopicheskoe issledovanie aeroX *ematicheskogo bar'era pri pnevmoskleroze 1 emfizeme legkikh. (Elec- !~rn microscopic investigations of the air-blood barrier in pneumoscieroemnhysema of the luncs.7 BVL'LL EKSP BIOL MED *13-114. 1970. [Engl, sum,j--Uttrastructural alterations caused by the ^nronic effect of copper oxide aerosol were studied. A marked thickening the basal layer of the thin region of the air-blood barrier and a rise *h the number of collagenous fibers were observed in rats. These chang* ** m*y be considered as a structural basis of gas exchange disturbances t*emoconi08ta.--C. M. M. 0 ~ *** KUDRYAVTSEVA, O, F* [Dzerzhinsk Inst. Ind. Hyg. Occup. Results obtained with them are inadmissible. The problem of normaliz ing systems of sampling and quantitative determination of toxins is pres sing and essential. Well-defined norms should be given regarding the speed of air sampling and the point or points where sampling is to be done. In evaluating the risk involved, the phenomenon of toxin condensa tion upon different surfaces of work areas which become secondary sources of pollution must not be forgotten. The only system appearing to show this part of the hazard is that of quantitative determinations in senes, even at times when the specific risk is theoretically null, so that characteristic profiles for each work cycle can be obtained. Even in this case, a standard method should be used to obtain comparable and' ' reproducible evaluations. This is the only way to obtain valid param eters of the hazard created by atmospheric toxins. These parameters 2 t *' Dzerzhinsk, USSR.) K kharakterlstike elektrokardiograficheskikh are essential for a program of organized and systematic prevention. enerUi u bolnykh khronicheskoi intoksikatsiei khloristym vinilom. --S. L. R. O LI 2526 I 717-729 ilfW--tiLs^i Sifitfi'iBilTiitiflM *~ --**--jfljiTlfl' - --- .fib // [Vol. 1 No. lj 70 NO regeneration of the necrosed zone was confirmed by the hyper* 723. SUKHAREVSKAYA, T. M.t L. S. SAVEL'EVA, and A. I. phagocytic response noted during- study of the clearance of colloidal Z VOROTNIKOVA. (Novosib. Sanit. Inst., Novosib., USSR.) Opyt pri- Ca particles* A comparable result was obtained after intragastnc meneniya < -aminokapronovoi kisloty pri khronicheskol Lntoksikatsii administration of tannic acid (2 g/kg of body welght)*-~S. L. R, benzolom i ego gomologami. [Experience using <*amlnocapronic acid in chronic poisoning with benzene and its homologuesj GJG I^PRQF 717. CHRISTOFFERSEN, PER (Kommunehosp., Copenhagen* Den.), 7 and KNUD NIELSEN. The frequency of Mallorv bodies in liver biopsies from chronic alcoholics. ACTA PATHOL MICROBIOL SCAN'S SECT A PAl'HOL 75(3): 274-278. 1971.--In liver biopsies from 287 consecutive chrome alcoholics, Mallory bodies were tound m 29. Of these, 18 had cirrhosis and fatty infiltration (corresponding to 44? of the total number of specimens showing cirrhosis and fatty change) and 11 (corresponding to 6?) had fatty change hut no cirrhosis, while Mallory bodies were not demonstrated in biopsies without fatty change. The incidence of Mallory bodies and alcoholic hepatitis in consecutive ZABOL 14^157: 39*41. 1970[recd. 1971],--* *Ammocaproruc acid, vitamins Bg and Bi2 glucose and Fe preparations were used to treat 12 patients with chronic poisoning by benzene and its homologues with symptoms of hemorrhagic diathesis. A hemostatic effect was obtained in 12- days in patients with mild symptoms of hemophilia and in 2-3 day days in those with pronounced manifestations of diathesis. In addition to the hemostatic effect, capillary permeability and the fibrinolytic activity of the blood decreased and blood coagulation time speeded up. The number of mature platelets increased after treatment and the num ber of old thrombocyte forms increased*--N. L. G. materials of liver biopsies frdm chronic alcoholics appears to be 10 and 8% respectively. 724. MAN'KO, N. N. (Inst. Hyg. Toxicol. Pestic. Polym. Plast. ASubst., Kiev, USSR.) Obosnovanie predel'no dopustimoi kontsentratsii 718. BASALAEV, A. V. (Gorki Inst. lnd. Hyg. Occup.Dis., Gorki, USSR.) Opyt prlmenenlya krupnokadrovoi flyuorografli pri ossledo vanll skeleta u rabotayushchikh v kontakte $ nepredel'nymi uglevodoraml etllenogo ryada (oleftnami) 1 lkh khlorprotzvodnymi Odilorvinil trikhloretllen). (Experience with the use of large-frame photoUuorography In examining skeletal bones of persons occupationally dealing with unsaturaled hydrocarbons of the ethylene series (olefins) and Uielr chlorine derivatives (vinyl chloride, trlchlorethvlene).! GIG TR PROF SABOL 14(11); 34-37. 1970. [Engl. sum.{--These examinations re p Foaalona v vozdukhe rabochei zony. [Substantiation of the maximum permissible concentration of Fozalon in the air of a production area. S5TRPff0f UbOL 14(12): 4'6qrarmus..iaw|red. 1971J.-The pesticide Fozalon (3 -00 -diethyIdithlo phosphorylmethyl-6-chlorobenzoxazalone) caused decreased acetylcholinesterase activity in the blood of industrial wodters in concentrations of 5.32 mg/m3. At a concentra tion of 11 mg/m3 in the air this enzyme is decreased by 30? in cats, which are more sensitive to the chemical. A maximum permissible concentration of 0.5 mg/m3 Is suggested. --N. L. G. vealed a definite reconstruction in the bones; osteosclerosis, osteo porosis, osteolysis and cystic changes. Traumatization of the limbs and prevalence in the clinical poisoning picture of these symptoms suggested lesions of higher vegetative centers, particularly of the hy pothalamic region. These changes may be of a neurodvstrophic nature. Large-frame photofhiorography may be recommended for roentgenologi cal examinations of the skeleton in occupational groups with potential bone pathology.--C. M. M. 725. KHANIN, M. N, and A. A. YULDASHEV. (Dep. Pathophysiol., U Tashkent Med. Inst., Tashkent, USSR,) K mekhanizmu povrezhdemya y deistviya geliotrina na pechen', (Concerning the mechanism of the * damaging effect of heliotrin on the liver.[ PATOL FIZlbL EKSP TER 14(4); bo-63. 1970. [Engl. sum.J--Tissue respiration of various organs was studied in Warburg's apparatus after the administration of various doses of heliotrin to rats. With a dose of 120 mg/kg disturbance of tissue respiration was seen only in the liver. LD._ and LD70 pro duced disturbances of gaseous exchange in all the organs studied. The 719. BRAKHINOVA, I. T., and G. V. SAMSONOV. Sravnitel'naya intensity of metabolic disturbances descended in the following order: M otsenka vllvaniya na organism nitridov perekhodnykh metallov 1 neme- y tallov. fComparative study of the effect of transitional metal and non- liver, brain, kidneys, Intestine, muscle, myocardium and spleen. The results of these investigations confirm the primary liver disorder * metallic nitrides on the body.l GIG TR MOfr ZAbOl "14(15): 48-50. and aid In the understanding of clinical manifestations of the disease l970(rccd. 1971J. --In experiments with white rats nitrides of non- during the action of hellotrln,--C. M. M. metals including BN, SI3N4, and BNC had weakly pronounced fibrogenle activity and caused pneumoconiotlc changes. Metal-Uke nitrides including TIN, ZrN and NbN in addition caused dystrophy of the liver and epithelium of the renal convoluted tubules. The recommended maximum permissible dose for nitrides of non-metals and NbN is 10 mg/m3, for AfN Is 4 mg/m3 and for ZrN is S mg/m3. The toxic ef fects of nitrides corresponded to their electron structure. Their biological activity decreased with the increased possibility of forming S2pu-electron configurations during interaction with N of non-metals and semi-metals and also d5-configurations with the formation of 726. ALEXANDER, J. F. (513 Med. Dent. Build., Regina, Sask, M Can.), and ROSA ROSARIO. A case of mercury poisoning: Acrodvma in a child of 8, CAN MED ASO i04(10): 929-SM Tflus. 1971.-- A can of mercury obtained from school had been taken home by 1 of the children of the family, All the children played with it daily In the house, the patient more than any of her sisters. The sensitivity of the condition to treatment with BAL [dlmercaprol] was demonstrated by the high level of Hg excretion by the 4th day after it was started, as well as by the patient's clinical improvement.--J. W. S. nitrides of transitional metals,--N. L. G. 720. KARIMOV, A. M. Professional'nye zabolevanlya kozhi u o khlopkorobov, vyzvannve yadokhlmlkatami, 1 meropriyatiya po lkh 2 profilaktike. (Occupational skin diseases in cotton growers caused by _ chemical poisons and measures for their prevention. I flip TR PROF y ZABOL 14(12): 35-37. I970[recd. 1971/--Dermatitis and eczema occurred in 30 persons out of 32 in direct contact with DDT and hexachlorane. The disturbances were of a seasonal nature. Of 633 cotton growers, the skin was sensitive to the phosphoorganic insecticides methylmercaptophos, octamethyl and butyphos in 42?. The time of development of sensitization to different chemicals varied and depended on body response, concentration of the chemical, work conditions and the nature of contact.--N. L. G. 721. AN, A. S., V. A. D'YACHENKO, V. I, IVANOV, and A. P. O TALIN. Opyt medikamentoznoi profllaktild porazhenli nervnoi sistemy q prl lntokslkatsli ognestoiklm maslom "Iwlof-3", (Experience in medical prevention of injury to the nervous system in poisoning with A the fireproof oil "Ivlor1".I GIG TR PkOF 2ab6l WT2): 37-3S. i970i reed. 1971J.--Persons working without gas masks in the remains of a breakdown at an electric power station were Intoxicated by the -fumes of *Tvlol*3** a compound based on trixylenylphosphate, vitamin E, vitamin Bg and phytln was effective in preventing damage to the nervous system.*-N- L* G. 722. ELISUI5KAYA, R. V. Sostoyanle plodovitosti u zhivotnykh G pri khronichcskom vozdeistvii parov metadizcpropilbenzola, [Condition 7 of fecundity in animals subjected to chronic efiects of metariiisoproJ: pylbenzene fumes.l GIG TR PROF ZABOL 14,11): 44-16. 197Qirecd. O 1971J,--White rats (45) with strictly periodic ocstral cycles were ex posed to the fumes of metadiisopropylbenzene in concentrations of 0.2 mg/1 and 1 mg/1 5 hr daily 5 times a wk for 5 mo. The course of the sexual cycle was disturbed with characteristic prolonged flow. The capacity for conception was substantially decreased. The average number of offspring decreased as well as their weight. Gonadotropic effects of the compound are indicated. Women's work in the presence of this compound should be regulated.--N. L. G. 727. SLONITSKAYA, N. N. (Leningrad Res. Inst. Antibtot., 2 Leningrad, USSR.) Toksichnost' levorina dlya beremennykh krys i ploda. (Toxicity of levorin for pregnant rats and fetus.) ANTIBIOTIKI 15(12): 1089-l4b3, lllus. 1970. [Engl. sum.|--The drug was given orally in doses of 1000, 500, 100, 50 and 10 mg/kg. Levorin used in single doses of 1000 and 500 mg/kg induced abortion and death in some rats. Administration of levorin in a single dose of 100 mg kg resulted in abortion and postimplantation death of the fetus. When the antibiotic was used repeatedly In the above dose, abnormalities in the fetal development were observed. The abnormalities were associated with non-union of the peritoneal wall and prolapses of the colon loops. In some fetuses abnormalities in the development of the eyes and cranial bones, brain were registered. On repeated use of levorin in a dose of 10 mg/kg abortion in some rats and post- implantation death of the fetus were observed. The level of the toxic effect of levorin was in direct proportion to the dose and the period of the drug use.--M. F. 728. SILVA, NEUZA O. G., and AMAURY T. L. ANDRADE. 2 (Fac. Med., Unlv,, Juiz de Fora, BraziL) The effects of thiophemcoi upon the rat conceptus, FERT STERIL 21(5): 431*433. 1610.-- Albino pregnant rats were given thiophenicol to determine the effect of the drug upon the conceptuses. Thiophenicol was administered i.p. (100 mg/kg of body weight) from the 1st to the 7th days of gestation on an every other day basis. The treated rats and controls were sacrificed on Day 19 or 10 and were examined for resorptions and malformations. There was a statistically significant number of resorptions in the thiophenicol group* the incidence of abnormalities was low in comparison to the number of resorptions. The results strongly suggest that the drug has a potentially deleterious effect upon the rat edheeptuses when given in the first 7 davs of pregnancy. - ,, . . --M. F. j-, (y i/y CM M *3 O 729. LEBEDEVA, A. F,, and L. A. MAROKUSHKIN. (Sanit.-Hyg. J Med, Inst., Leningrad, USSR.) K voprosu 0 mekhanizme narushenlya funktsii nervno-myshechnogo apparata pri vozdeistvii vibratsu. [Mecha- FREQUENCY QF AFLA TOXIN AND ASPERGILLUS IN FOODS/ MILK PRODUCTS WHEAT-** HAT RYfi-M CORN-** BRA0 NOOOLES FRUIT PRESERVES lEGUME-0 >1402*82 PACE 111*-112* PAULET G CHFVRIER R EFFECT OF COBALT ON CARBON **QN QXIOE DE TOXIF (CATI ON/ RABBIT HCMO GLOBlN -6300*0 *7440484 PAGE lJ99-1202 MAUREL E B0U1SS0U H CARLES J SOME EFFECTS OF INDIUM POISONING ON THE METABOLISM OF UREA/ RAT *7*4074* PAGE 1224-1227 NONJOUR L MAR|AGE C INTERFERENCE OF AFLA TOXIN IN THE PROTEIN SYNTHESIS OF THE RAT THE PROBLEM OF NtO ANTIGENS/ ASPER6ILLUWLAVUS RABBIT IMMUNOLOGY CANCER -14026*2 PAGE 1251-1254 MONJOUR L MARUGE C SERUM ESTERASES ANO AFla TOXIN/ RAT HtPATO CARCINCMA IMMUNOLOGY NEO ANTIGEN PROTEIN BIOSYNTHESIS *14026*2 PAGE 1261*1245 J AM NED ASSOC 214 112). 1970 DOTT A * BLOOD ALCOHOL LEVELS ANO INTOXICATION/ LETTER HUMAN *64175 PAGE 219* EXPERIENTIA (BASEL) 2* U>. 1970 YOUNG M THE MECHANISM OF TETRCOC TCXlN ON THE IN-SITU ACETYL CHQL1M ASTERASE IN THE VAGAL HEART SYSTEM OF RANA-PlPIlNS/ PUFFER PISH *11005659 PAGE 592-591 K0ST1R 4 UCHAR E MACHACKOVA I JlRACEK V INFLUENCE OF SULFUR 01 CXIQE ON THE CONTENT OF FREE SACCHARIOES AND AMINO-ACIDS IN SEEDLINGS OF PEA5-0/ ALANINE GLUTAMIC-ACIO TOXICITY *7446095 FACE 604-405 THOMPSON J H SPfll* C A ANGULO M CHRONIC EFFECTS OF NICOTINE ON RAT GASTRIC SECRETION/ TOBACCO-0 SNORING PEPTIC ULCER ETIOLOGY *54115 PAGE *15-417 KAR P P DtRSHlTH T S S DERMAL TOXICITY OF OQT/ GUINEA-PIG INSECTICIDE SKIN AMINQ-ACIOS CHROMATOGRAPHY CYTOLOGICAL STUDY *50295 PAGE 654*439 CHURCHILL P C SECRETION OF RENIN [N ANESTHETIZED RATS/ ABSTRACT PARA AMINO HlPPURIC-ACI0 P6NTQ BARBITAL CCNT-OEPRESS-DRUG RENAL PLASMA FLQM PAGE 4-79 0LEAG1NEUX 25 112). 1970 MANN H BEHAVIOR OF DETERGENTS IN COASTAL MATERS/ ABSTRACT FISH OEGRAOATlCN PAGE *B1 BOCK R J HtCKBOLO R DEGRADABILITY OF NON*(ONIC TEN$IOACT|VE COMPOUNDS IN PURIFICATION INSTALLATIONS/ abstract hater PAGE 6*1-612 HYDRO*IOL J Sit), 1969 MILOVIOOVA N Y BIOMASS AND RESERVES OF MACRC {DO BENThCS IN THE BAYS OF THE NORTHEASTERN PART OF THE BLACK SEA/ DISTRIBUTION POLLUTION > PAGE 35*51 SINEL N[KOV V E MIKHAYLOV V A THE QUANTITATIVE DETERMINATION OF HATER SURFACE POLLUTION UITH BITUHENOIOS/ EF*|N FLUORIMETER LUMINESCENT PETROLEUN FRACTION RESERVOIR HXI002059 PAGE 43*46 IL YIN I N MARINE BORERS FROM OUR LITERATURE/ TEREOINIDAE A S KONSTANTINOV CRITIQUE DISTRIBUTION CONTROL ECOLOGY PAGE 61-B2 LA* PRACT 14 I 121.. 19*9 MENON 1 *5 EFFECT* Q CARBQlJI 01 ACTIVITY/* HUMAN *1243*9 PAGE 12*4-1285 OXIDE INHALATION ON BLOOD FIBRINOLYTIC **'"'* Mir..; /-2- (Vo* 1 Mg i EXPERIENTIA IBASELI 26 I 111. 1970 TIRA S GA16FFI C 0! M0Q1CA G FLAVONOIDS OF CNAPMAlIEAE-0 L0NTOPO01UM-AlPINUN-0/ FROG MOUSE TOXIN CHROMATOGRAPHY PAGE 1192 RATO H SUZUKI T STRUCTURE OF BRADY KlNlN POTENTIATING PEPTIDE CONTAINING TRYPTOPHAN FROM THE VENCM OF AGMSTRQOON-HALYS-BlOmhOPF11/ PAGE 1205-1206 DUCKETT S FETAL ENCEPHALOPATHY FOLLOWING INGESTION OF TELLURIUM/ RATS *1002*167 PAGE 1259-1241 J PE01ATR 74 161* 1949 MCNICHOLL B KllROY M K TRANSIENT HYPERTENSIVE ENCEPHALOPATHY POSSIBLE RELATION TO LICORICE/ CHILD GLYCYRRHIZ1C-AC10 >1405**1 PAGE 9*5-964 ND ANN 0 C 40 111. 1971 SILVER H M CARBCft MON CXtOE IN HEALTH ANC POLITICS/ USA HUMAN SMOKING A|R POLLUTION *10QB0 PAGE 169-171 NEO J 9i m* ROYAC A PARAC 6 KURAJICA l JURIC*RUZIC 0 acropathia extremitatum in polymerisatione vinylchloridi hem OCCUPATIONAL DISEASE/ HUMAN EXTREMITIES BONE CHANGES POLY V1NY CHLORIDE *PM9002*62 PAGE 1-12 NARK1CEVIC A AN UNUSUAL SYNDROME OF ACRCPATHY AS A NH OCCUPATIONAL 0I&EASE/ HUMAN EXTREMITIES PAGE 70*73 C R SEANCES SOC BIOL F1L 145 U). 1969 MONJOUR L MARUGE C EMBRYONIC ANTIGENS ANO AFLA TOXINS/ RAT HEPATIC CARCINOMA TERATOGENESIS *1402682 PAGE 12*0*1290 BOUTON C MULLET N FEInTuCH STUOY OF THE EFFECT OF GlBBERElLIC-ACIO IN AOULl CASTRATED RATS/ STER010 PRECURSOR GENITAL ATROPHY *77065 PAGE 1302*1104 MJ MALE RQUOltR R ROUSSEL A GOOIN J STUOY OF THE CEREBRAL CAPILLARIES DURING THE CONFINEMENT OF MICE/ CARBCN MON CxlOE CARBON 01 OXIDE POISONING NEURO SECRETION MENINGEAL CONGESTION sex DIFFERENCE *124389 >4300*0 PAGE 1304-1509 GUERIN M W4LL0N G EFFECTS OF THE SUBSTITUTION OF CESIUM FOR POTASSIUM (N (he PERFUSION LIQUID OF ISOLATEO TORTOISE HEARTS PART 2 BALANCE conoitionS at variable relative concentrations qf potassium and cesium/ CELL CESIUM ACCUMULATION TOXICITY *74404*2 PAGE 1324-1527 CARA M 60LCBERG APOISVERT M CARA G STUDY OF THE EFFECT OF A VASff DILATOR ON CONVULSIONS CAUSED BY HYPER BARIC OXYGEN/ MOUSE HYOERGlNE ANTIOOTE-ORUG *101473 *7782447 PAGE 1340-13*1 LAFQNT J FRAVSSINET C MyCO TOXINS PRODUCED BY ASPERGILLUS ThEIR EFFECT ON CHICK EMBRYOS/ TERATOGENS PAGE 1362-1364 BRISOU J DENIS F USE OF BACTERIA TO DETECT CERTAIN PESTICIDES/ FLAV0BAC7ERIUM BACILLUS-LIChEn]FORM]S ANIMAL SHELL SEA ATR PAGE 1426-U27 KIRCHMANN R KOCH G LAFONIAlME A VAN DEN HQEK J TRITIUM TRANSFER AND DISTRIBUTION IN THE MAIN CONSTITUENTS OF MILK FROM COWS FED WITH CCNfAMINATED MATER *10029170/ PAGE 1439-1*63 EXPERIENTIA (BASEL) 27 (11, 1971 18*7 ' GHIRARDt P MAR20 A SARQtNl 0 NARCHETTI G CHANCES in intestinal ABSORPTION of glucose in rats with ETHANOL/ ALCOHOLISM SIGNIFICANCE *50997 *64175 treated 00 d in d H 8 FirfrW - JS 2277-2287 "m*. v H* to ***** K >40 W ffc * 4* such as endrin, chlordane, toxaphene or chlorinated bl- 2282. KASHYAP, S. K. (All-India Inst. Med. Set., New Delhi, detected in the specimens analyzed during tins in* Delhi, India.), and S. K. GUPTA. The effect of occupational exposure ^ioa.-C- M. M. 0 to organophosphorus pesticides on blood cholinesterase. INDIAN J MIKAELYAN, E. M,, and V. G. MKHITARYAN. (Yerevan Inst., Yerevan, USSR.) Sdvigi v soderzhami aramiaka, * ,j | imidnykh grupp belka (legko- 1 trudnogirirolizuemye) "* * ^dylch krys pri khloroprenovom otravlenli. (Shifts in the ...i,nn of ammonia, glutamine and the amide groups of proteins, ' --ySFnivzed and not easily hydrolyzed) in the brain of while ' :-I53wtth chloroprene.! BIOL ZH AkM 23(5); 39-44. TTSIute rats were poisoned through inhalation of chloroprene ur 3 hr. The concentration of chloroprene in the chamber was * The periods of poisoning lasted 30, $0 and 90 days. As a p hifcD RES 59(2): 289-243. Illus. 1971.--Results oi blood cholines z terase activity measured by tintometric method in 158 males of Delhi and Punjab, including 84 occupationally exposed to organophosphorus pesticides and 74 unexposed persons were reported. The blood cho linesterase [ChE] levels in unexposed persons were in lower range in comparison to values reported for European adult males. Tne ex posed group of individuals showed significant depressions cholines terase levels as compared to that of normals. A significant relation ship of blood ChE activity with the total duration of exposure, the time since last exposure and the presence of symptoms In the occupationally exposed persons were observed. ``'4 chronic chloroprene poisoning, the concentration of free ^r.1 in the brain increased significantly, while the concentration ' VA=ine decreased. The concentration of readily hydrolyzed 2283. KAW, J. L. (Inst. Lufthyg. und Silikoseforsch., Duesseldort, '' (roupS of protein scarcely underwent any changes. Amide of protein that were not easily hydrolyzed increased by 50% W. Ger.), G. S. D, GUPTA, and S. H. ZAIDI. Lung Holds and pulmon z ary silicosis In rats, INT ARCH ARBEITSMED 27(4): 324-15(5. Illus. . W days of poisoning, decreased by 60% after 60 days of poisoning [. lOrned to normal by the 90th day of poisoning. An increase . m degree of amidtzation of proteins is a defensive reaction of the to the toxic action of such high concentrations of ammonia. , (. inf mo. of poisoning the organism adapts slightly to the acticuf . vTUptchC.-'L, K. R. 1971.--in the development of pulmonary silicosis in rats studies on changes in the total, esterified, free cholesterol and phospholipids were made in lungs, liver and blood plasma over a period of 200 days. Total cholesterol. Us fractions and [kiospholipld content increased with time in the lungs of silicotic animals. Hlslochemically sudanophllic materials were observed in the cytoplasm of pulmonary macrophages. Changes similar to those of lungi were not observed in liver and blood ;)7I. DATSENKO, L I. Obmennye reaktsil v organizme v usloviyakh plasma; the increased lipid content at lungs during experimental pul ubeskoi lntoksikaisil okis'yu ugleroda. (Metabolic reactions in monary silicosis may be due to the localized degenerative action of . . . under chronic carbon monoxide poisoning.! t'AKTORV silica on macrophages. 'W 5REM ZNAdh ENlE fcDOROV'YA naSeleniya resp ctIVED SB 2. 146-149. 1970. Translated from REF ZH OTD - j rxRMAKOL KHIMIOTER SREDSTVA TOKSDCOL, 1971, No. 2.54, : Rats were subjected to the chronic action for 5 hr dally of CO < 1 ravennation of 0.009-0.018 mg/1 for 1.5 mo., at 0.03-0.04 mg/1 t nxber 3 mo. and at 0.08-0.1 mg/1 for 1 mo. Under the action of - T> there was a persistent Increase in the concentration of total Mtiirul in the blood.--8. T. 2284. MUELLER, W,, and G. HOLZAPFEL. (Inst. Arbeitshyg., Unlv,, Jena, E. Ger.) Ueber die Beziehung zwischen Delta-Aminolaevu> linsaeure-Ausscheidung im Harn und Blutbleispiegel bei Arbeitern mlt 5" unterschledlicher Blelexposltion. (The relationship between A LA in O urine and lead in blood in workerswith dlMerent lead-exposure. I INT Ml*. PERRY, H. MITCHELL Jr. (Wash. Unlv. Sch. Med., St. Ho, 63106, USA.), ELIZABETH F. PERRY, and JAMES E. t * CJOT. Antlnatrturetic effect of intramuscular cadmium in rats. ARCH ARfeEITSMEb 22(4): $31 -337. Illus. 1971. |Engl. summ.] --In 3 groups of differently exposed lead-workers the relationship between ALA [gamma-aminolevulinic acid] in urine and Pb in blood was In vestigated, This relationship is not constant and depends on the kind *a SOC EXP BIOL MED 136(4)- 1240-1244. Ulus. 1971.--During and intensity of exposure. It is difficult to establish an acceptable * id day after an i.m. injection of 1 mg of Cd/kg of body weight, limit value of the ALA-output In urine. Women seem more sensitive rui NO g rats averaged 42 pEq less urinary Na than control ani*s This antinatrluretic effect increased with successive doses of to Pb than men. - 'ttbing an average of 68 uEq after the 4th such dose. There was `vrvjponding increase in weight on the day after each Cd injection. *<*w<i nurturesis was observed 1 and 2 wk after the 1st dose of Cd. *m bit evident after the 2nd dose and was completely absent after * Vi >nd 4th doses. Cd produced no corresponding change m urin** tbme, protein, K, Cd or Zn. Six months after the 4th Cd injeu- ti-re was no hypertension but there was a suggestive, if lnslgntfi" arrease in peripheral renin and a decrease In responsiveness to *~*"Uftrine but not to either angiotensin or Cd.--C. M, M. 2285. BASALAEV, A, V. (Gorki Inst, Ind. Hyg. Occup.Dts,, Gorki, USSR.) Opyt primeneniya krupnokadrovol flyuorogralii pri ossledovanii skeleta u rabotavushchikh v kontakte 9 nepredel'nymi uglevodorami etilenogo ryada (olefinaml) i ikh khlorproizvodnymi (khlorvinii, trikhloretilen). (Experience with the use of large-frame photofluorography in examining skeletal bones of persons occupationally dealing with unsaturated hydrocarbons of the ethvlene series (olefins) and their fit* CANDURA, F., G. FRANCO, and U. POZZI. (1st. Med. delFUnlv., Sassarl, Italy.) Influenza del caiore suH'aitivtta * *drataafea eritrocitarla nel conigllo e nelTuomo. I: Indaginl *" oilcazione da plombo. (Influence of heart on the ALA -dehv- chlorine derivatives (vinyl chloride. tricblorethvlene).| GIG TR PROF 2Ab6L 14(11); 34-37. 1970. [Engl. sum.J--These examinations re vealed a definite reconstruction In the bones; osteosclerosis, osteo porosis, osteolysis and cystic changes. Traumatization of the limbs and prevalence in the clinical poisoning picture of these symptoms "JTL'rytlu-ocvte activity In the rabbit and man, I LAVOflO UMANO suggested lesions of higher vegetative centers, particularly of the hy to. Iltus. 1071. (EngL surom.J--The influence of heat on delta pothalamic region. These changes may be of a neurodystrophic nature. ** eiuiinlc acid (ALA)-dehydratase in rat, rabbit and man, both in Large-frame photofluorography may be recommended for roentgenologi conditions and under Pb-Intoxication, was observed. Innorma! cal examinations of the skeleton in occupational groups with potential the rat was unfit for the investigation. The activation process bone pathology.--C. M. M. ,t>rn'ic treatment differed in rabbit and man. A reduction of '"* en, In the rabbit and an increase was observed in man. `lnt0*lcatlon, an Increase of enzymatic activity was shown "melts as a result of pre-heating.--C. M. M. 2286. BRAKHINOVA, I. T., and G. V. SAMSONOV. Sravnitel'naya ,-J,uTAKEUCHI, JUGORO, AKIRA TAKADA, YOSHIO KATO, ,,UMURA- FUMIAKI DCEGAMI, and YOSHIRO MATSUDA. ,.''iylnlzl'va Unlv., Kanazawa, Jap.) Hepatic changes in r p-Joholic rats following periodic acute alcoholic intoxications. nuTr 24(6): 628-634. Illus. 1911.--Rats consuming * nj' J5*`20% alcohol mixture In their drinking water, received - ,T -,1*5 mt of a 40% alcohol sohition/100 g body wt once weekly - -, 1 I* Production of hyaline bodies, fatty change and elevated .. glutamic oxalacetic transaminase activity were all . ' r3fs consuming alcohol chronicallv and acutely (double than in the rats consuming it onlv chronically (single -Pi. As the total caloric intake and the caloric proportions , -,'Jn,t*le caloric Intake were virtually identical in both uferences in the hepatic lesions and iunction were attn- i th Ct'n of lcute'/ administered alcohol. The hepatic otsenka vliyaniya na organlzm nitridov perekhodnykh roetallov i nemeM tallov. (Comparative study of the effect of transitional metal and nonX metallic nitrides on the body,] GIG f*R PROF ZABOL 14(15); 46-30. z 1970(recd. 19?i].--In experiments with white rats nitrides of nonmetals including BN, SijN^ and BNC had weakly pronounced fibrogenlc activity and caused pneumoconlotic changes. Metal-like nitrides including TiN, ZrN and NbN in addition caused dystrophy of the liver and epithelium of the renal convoluted tubules. The recommended maximum permissible dose for nitrides of non-metals and NbN is 10 mg/m3, for AIN is 4 mg/m3 and for ZrN is 5 mg/ml. The toxic ef fects of nitrides corresponded to their electron structure. Their oipl c.cul activity decreased with the increased possibility of forming -electron configurations during interaction with N of non-metau and semi-metals and also d$-configurations with the formation oi nitrides of transitional metals.--N. L. G. ' aii, "f rMs f'd serotsynthettc diets were more prominent than ' - .t;r 1 commercial diet. Hyaline bodies can be pro- ' ">- ^ administration of alcohol. The severity of `"v, hT, cllnges is related to the manner of alcohol ingestion and "t'ors.-c, M. M. 2287. KARIMOV, A. M. Prolessional'nye zabolevaniya kozhi u khlopkorobov, vyzvannye yadokhimlkatami, i meroprlyatiya po ikh prolilaktlke. [Occupational skin diseases in cotton growers caused by O LI 2529 f I' THE ANALYSIS OF FEED EFFICIENCY OATA AS RELATED tO VARIOUS DECREES OF AFIA TOXICOSIS IN GRQwlNC SwlNE/ ABSTRACT LIVER INJURY ICTERUS >14026*2 FACE 29| 2AAR NUtRC G S COLDUELS ^ 9 TRENnOLN H L the DEVELOPMENT OF A SYSTEMATIC method FOR TOXICOLOGICAL RESEARCH USING AN INTEGRATED MULTI DISCIPLINARY APPROACH/ AASTRACT ANIMAL ETHANOL AARfITURATE DRUG INTERACTIONS *44175 >47527 PAGE 291 2170 HARTMAN H HAAS R CARTV P A VERSATILE DATA PROCESSING SYSTEM DEVELOPED FOR ANIMAL REPRODUCTION AnO TERATOLOGY OATA/ AASTRACT COMPUTER PAGE 291-242 tin YOURILIS 0 J MORROW A J FORNEY R A ACUTE CAROtO VASCULAR RESPONSES TO CAONtUM/ AfeSTRACT RAT CORONARY VASCULAR RESISTANCE MYO CARDIAL COMTRACTAL FORCE CATECHOLAMINE RELEASE >7440499 PAGE 242-299 2AT2 CRESS C R LARSON R E LEAD ANO LINDANE INTERACTIONS ON HEn SYNTHESIS IN THE MOUSE/ AftSTftACT HUMAN PESTICIDE ANEMIA ENVIRONMENTAL CONTAMINATION NEMO 0108IN >51499 *7*34921 PAGE 241 2*79 MOWN 0 R MURPHY S 0 INFLUENCE OF AGE $fX AND HORMONES ON TRI ALKYL PHOSPHATE INDUCED NARCOSIS IN RATS/ ASSTRACT OIMETHOATE PESTICIDE NARCOSIS >60515 PAGE 299-244 2174 GASKINS J R MfiHIR R N MCCAULLCY 0 F LICON I N JR ACUTE EFFECTS OF CHLQROACETOPHCNONE ANO ORTHO CHLOROMNIVLIDENEMAlONONITRILE IN RATS ANO RAMITS/^ AISTRACT TEAR GASES CASTRO ENTERITIS CORNfAL IRRITATION PURPURA NECROTIC ESCHAR >249*411 >134124* PAGE 245 IITS ALSTCTT R L BROWN 0 J FORNEY R ENZYMATIC ACTIVITY PATTERNS IN THE RABGIT AFTER CAFFEINE ETHANOL AOMIN ISTRAtION/ ABSTRACT SHOCK AVOIDANCE GOT -5*0*2 *44175 PAGE 24A 2*7* RIUENS R L DOM*ROS*I F HENDERSON M P CAMPtCLL R 1 EFFECTS OF NITROGEN 01 OXIDE ON ENZYME ACTIVITY IN RAT TISSUES/ ABSTRACT LUNG LIVER kSONEY HOMOGENATES ALDOLASE LACTIC DEHYDROGENASE ALKALINE PHOSPHATASE *10102440 ' "'PAGE 244*24? 2*77 WATKINS M 0 TEPHIV T R LIVER ALCOHOL DEHYDROGENASE AND RETINAL ALCOHOL DEHYDROGENASE/ ASSTRACT RAT ALCOHOL CHROMATOGRAPHY OMOPTION TOXICITY >44175 PAGE 247 2*7* SACHMANN E 60LIERG L DIGtACDNO P MJTOCHONORIAL EFFECTS OF ETHYLENE GLYCOL IN-VITRO ANO IN-VIVQ/ AIStRACT RAT DOG MO*EV MACACA-HULATTA ELECTRON TRANSFER OXIDATIVE PHOSPHORYLATION -107211 PAGE 247*249 2*74 FOVEAS J M HENNIGAR G A JR OOUGMCRTY V A NICHOLS 4 ULTRA5TRUCTURAL MtSTOCHEMICAL CHANGES IN PUREBRED CANINE MlPATIC CELLS FOLLOWING ACUTE FEEDINGS Wit* ODD/ ABSTRACT OOT PfRTHAMf .INSECTItlOES PENTG BARB ITAL CfNf-DEPRESS-DRUC ATPASE TPNH DIAPHORASE >T24B *74744 >50249 T2540 PAGE 4 2BB0 HACKLY G R GlOTH 0 H NfAO N L LIGHT MICROSCOPIC AND ELECTRON MICROSCOPIC STUDIES OP BERYLLIUM HYDROXIDE INDUCED RAT PULMONARY TUMORS/ ABSTRACT >1904440 PAGE 244 2BI VQGIN C t CARSON S NORGAREtOGE R PICK H N 2 YEAR CHRONIC TOXICITY STUDIES WITH MOIETIES OP NICARBAZIN/ POULTRY DOG RAT HUNAN SAFETY LEVELS >920490 PAGE 249*900 2102 BOyO I N too DAV LDSO INDEX OF CHRONIC TOXICITY/ ABSTRACT RAT ATROPINE PILOCARPINE ASPIRIN PHENACEftN PARACETAMOL SUCROSE SODIUM CHLORIDE CAFFEINE OtCOPHANE PCIUCtOf ORAL *40249 *57501 >10712 *42442 >51590 -5*012 109402 *7447145 >42197 PAGE 900 21*1 MANSeN M H COLLINS T P t G**MAM 1 V JACOBSON K N CHRONIC ORAL TOXICITY OP ERYTHROSIME IN BATS ANO GERBlLS/ ABSTRACT OUT THYROID FUNCTION >11407* PAGE >00-901 2**4 LEVlNSRAS G J SHAFFER C B TOXICITY OP ABATE A MOSOUITO LARVICIOE ANO ITS SULFOXIDE/ ABSTRACT RAT RABBIT MEN DOG *39B19*B PAGE 901-902 21*5 GOUGH B 4 SNELLENIERGER T 6 IN-VIVO EFFECTS OP QXIME REACTIVATORS ON ORGANO PHOSPHATE INHIBITED BLOOO CHOLtN ESTERASE/ ABSTRACT RABBIT PAGE 90S 2UA RAMA SASTRT * V CHIOU C Y SOME ASPECTS OP THE BLOCKADE OF NEURO MUSCULAR TRANSMISSION BY IODO ACETATES BROMO ACETATES ChlQRO ACETATES ANO FLUORO ACETATES AND THEIR CHOLINE ESTERS IN THE RAT PHRENIC NERVE DIAPHRAGM PREPARATION/ ABSTRACT 0 TU*0 CURARINE ANTIDOTf-ORUG PHVSOSTIGMINE >144490 *4*5T >74019 *74UB PAGE 909 2BBT COHEN S 0 MURPHY S D OOSE AND TIME RELATIONSHIPS FOR CARBOXYL ESTERASE INHIBITION ANO MALATHlON POTENTIATION BY ThtI*P-N|TROPhfNYL-ThICVO-BNZENE PhOS*M"NAT O-6ThYl"0-*-Nl?ACP6NYL PhFNU pNgsPMCNCT^iri75 A>TS AN.1 pa;k riCN/ ABSTRACT house INSECT itIQS -210*44.5 >33*394* >563*2 *121755 PAGE 303-lQ* 2SB8 LOCKE R K BECK V BARON A L META&OLISM Of CARBAMATE INJECTICIOES UTILIZING CELL CULTURE TECHNlBUES/ ABSTRACT L-L32 HUMAN EMBRYO LUNG CARBARTL BaNOL UC-34Q9* N-4-N METHYL CARBAMOylDXy-O-IQLTL-N K 0| METHYL FQAManIOINE **71045 >1770257? *41292 OLI 2530 // tVoL | No. 3] , PAGE 304 2*14 HI HE C H SIOMKA M b HUMAN TOXICITY STUDIES ON POLY VINYL CHLORIDE FORMULATION OF 01CHLQRVQS/ ABSTRACT ANTI HELMINTH CASTRO INTESTINAL TRACT -4273T PM4O02842 PAGE 304-90S 2I4D SMALLEY H E RAOELEFF R 0 COMPARATIVE TQXICITT OF THE HERSICIOC PARAQUAT IN LABORATORY AND FARM ANIMALS/ ABSTRACT GUINEA-PIG HAMSTER SHEEP SWtNE PNEUMONITIS DEATH 4485147 PAGE 905 2*41 STEWART I 0 PETERSON j ( BARtTTA ( 0 EXPERIMENTAL HUMAN EXPOSURE TO CARBON MON OXIDE/ ABSTRACT CARBQXY NEMO GLOBIN >430080 PAG! 305-904 2842 MAHNO J 6 FORNEY R RIPLtNGER 6 R BENNETT | HUMAN MOTOR AND MENTAL PERFORMANCE UNOfR THE INFLUENCE OP ALCOHOL ANO OR MARIHUANA/ ABSTRACT DELTA-4 TEtRA HYDRO CANNABINOL ChROMATOGRAFHY -6*175 PAGE 90* 2149 CARTER V L JR PARKER 0 N BACK X C THE EFFECT QP BROMO TRIFLUORO METHANE ON OPERANT BEHAVIOR IN MONKEYS/ ABSTRACT fiat SUPPRESSING AGlNT >79*lB PACE 107 2*44 MILLER B VAN LQON E J NlCHEL T C OLlVITO V L CENTRAL NERVOUS SYSTEH SUPER SENSITIVITY TO CHLORINATED PESTICIDES AND PENTYLENETETRAZOLE AFTER CHRONIC BARBITURATE ADMINISTRATION/ ABSTRACT DOG OIELORIN LINDANE PhENO BARBITAL CONVULSIVE threshold >*os7i -54*99 >500** >54995 page sot 2*99 SINGH 4 N PRAZOID L EFFECT OP ATROPINE OH PESTICIDE CARRARYL I NAPHTHYL N-METMYL CARBAMATE INOUCE0 BEHAVIORAL CHANGES IN RATS/ ABSTRACT SI55B *43252 PAGE 1002 2B4* HARTUNC R RIGAS l R CORNISH H H ACUTE AND CHRONIC TOXICITY OP PI ETHANOLAMINf/ ABSTRACT CARBON D| OXIDE HYDROGEN 01 SULFIDE INDUSTRY LIVER LIPIDS iHfMU RESPIRATORY DIFFICULTY -77*3044 >1249*9 PAGE 901 2*41 HAUM c C EGAN P MACEVEN 4 0 VERNOT E H ACUTE TOXICITY AND PROPOSCO EMERGENCY EXPOSURE LIMITS OP NITROGEN TRt PLUORIOE/ ABSTRACT HUMAN VORAERS MOUSE RAT DOG MONKEY ROCKET PROPELLANT MET MEMO GLQilN FORMATION DEATH -77*3542 PAGE 90L 2B4B FIRING LUNG CLEARANCE OP TITANIUM Ot OXtOt PARTICLES IN RATS/ ABSTRACT INHALATION >1904*99 2144 PAGE 301 ULRICH C E HADDOCK R H JENNINGS K J ALARIE V MEASUREMENTS OP RESPIRATORY SYSTEM PLOW RESISTANCE IN CVMOMQLGUS MONKEYS/ ABSTRACT MAC4CA-1AUS AIR BORNE MATERIAL REGRESSION ANALYSIS PAGE 909 2400 ALARIE Y ORVII E P ULRICH C E MACPARLANO H N KRUNM A EPPECTS Of LONG-TERM CONTINUOUS EXPOSURE TO SULFUR 01 OXIDE IN CYNOMOLCUS MONKEYS/ ABSTRACT PULMONARY SYSTEM NEGATIVE TOXICITY >744*095 PAGE 109 2401 SWANN H E JR ALARIE V ULRICH C E NACP4RLAH0 M N EFFECTS OP LONG-TERM CONTINUOUS EXPOSURE TO SULFUR DI OXJOE IN GUINEA-PIGS/ ABSTRACT CARBON MON OXtOE UPTAKE SURVIVAL PULMONARY FUNCTION NEGATIVE TOXICITY >7444099 >6900*0 PAGE 109-110 2402 GUSEV V M SWANN H E JR ALARIE Y HISTO PATHOLOGICAL EFFECTS OF LONG-TERM CONTINUOUS EXPOSURE TO BULPUR 01 OXIDE IN GUINEA-PIGS ANO CYNOMOLCUS MONKEYS/ ABSTRACT LUNG ALTERATIONS MICROSCOPY >744*095 PAGE 110 2501 TURK R P JAIN N C PHILLIPS A N FORNEY R 8 MANNO J C PREPARATION ANO PRESERVATION OF DELTA-4 T*TAA MYORO C*NNA*IN0L/ ABSTRACT marihuana CHROMATOGRAPHY NMR mass SPECTROSCOPY NITROGEN STORAGE FREEZING PHARMACOLOGY TOXICOLOGY PAGE 310-311 2404 MAHNO I R FORNEY R B MANNO J f KtLSHElME* G S RESPONSE OF THE ISOLATED PERFUSED RAT HEART TO DELTA-9 TETRA HVORQ CANNABINOL/ ABSTRACT HUNAN MARIHUANA SMOKING TACHY CAR01A GAS CHROMATOGRAPHY PAGE 911 2405 PHILLIPS R N TURK * F FORNEY B B TOXICITY OF DELTA-9 TETRA HYDRO CANNABINOL IN RAtS AND MICE/ - "1BSTRACT MARIHUANA BEHAVIORAL OBSERVATIONS CHROmaTOGRAPHV NMR NASS SPECTROSCOPY INTRA VENOUS INTRA PERITONEAL ORAL PAGE 911 240* RQ5ENGLUN t SfRRQNt D N KILLEEN J C JR RADLEY J WILLS J H COULSTQN f " AN EVALUATION OF THE EFFECTS OF MONO SODIUM GLUTAMATE IN MAN ANO ANIMALS/ ABSTRACT RAT RABBIT MONKEY CHICKEN SOUP >142*72 PAGE 114 2407 GUESS W L CAUEY 0 J SOME FACTORS AFFECTING INTRA CUtAhfOUS IRRITATION TESTS IN RABBITS/ 45SIRACT PACE 315 293* CA4NMER M F EFFECT OF Dt PHENYL HY0ANTO1N QN STORAGE OF OQT IN Th* ftlT/ ABSTRACT RAT OtliNflN DOE LIVER MICROSOMAL ENZYME ACTIVITY >57410 *72559 >5Q243 MAGE 7315* * 2409 GRAHAM S*L HANSEN W H THfi*EP|ECrS 0* SHORT-TERM ADMINISTRATION OF ETHYLE*? 'hIO UREA UPON THYROID FUNCTION IN THE RAT/ ** *n>__ *^*#*t*^ -N 4 /S' ADDITIONAL BIBLIOGRAPHIC CITATIONS* t dUtions which are fisted here are published without abstracts, since they are derived from BioResearch Index. The primary m of the citations are conferences, symposia, reviews, notes, preliminary reports, etc, which are not included in the publication Logical abstracts. ^iiMMf'iMiiMeM^MMeHeeeeeeeeeesMneeasMeteeeeMaeOtee* C'wtW NORTH AH * f|, 1471 -************************************* fAADLfV G f MtfUAT SCREENING TESTS IN THf INFANT ANO YOUNG CHILD/ ftlCTCIU*lA LfAO POISONING URINARY DISEASES METABOLIC flSfASCS T4|SI nti 14ST-I4TI ^^e******************************#****#**************- **** tfVJPlMQCHf 4 (44). 1464 - PCYfR A nTtMMSiS ano therapy or benzene intoxication/ j6Alt NYfCftCMftONIC ANENU LEUKOPENIA THROMBOCYTOPENIA SULFATE flAMtlSM ASCORBIC-ACID INTESTINAL AfSORPTIVE DISORDER VITAMIN ft DEFICIENCY VITAMIN E DEFICIENCY PHCNACETIN IRTOXICATION *TU32 *62442 >59029 *90*17 FACE ltT4*ll gfMMM*f******t*itiemtf***fetaetit*etMtt*eMtevMie*iei* <VBS (FID EUR V IOCHEN SOCI LETT |f III. 1911 ttAHatFFE T C P1RIE A TNf PRODUCTION OF SUPEROXIOC RADICALS IN REACTIONS OF TTC MtBIClOC OIOUAT/ TOXICITY FACTOR *42t54 PACE 2Y7-24Y m MlillON N f REGULATION OF HEPATIC ELIMINATION OF ETHANOL IN-VIVO/ Alt PROmrNIO URACIL PROMETHAZINE CL9FIBRATE METaB-DRUCS UCOttL OfKTOROCENASf EC-l.l.Wl -40*77 >437070 >44174 *41429 PAGE MMOS * REREt A HORGiT A-L PRONAGEQT P tORSCRAY A-M ROOUIT F CKANGfUI J-P TRITIUM LABELLING OF THE ALPHA NEURO TOXIN OP NAJA-NIGRICDLLIS/ POLT PEPTIOI -47443 PAGE 313-139 m* CSIlLAG A THE EFFECT OF IRSENtTE ON RAT LIVER MITOCHONDRIA/ 0X0 GIUT4RATE OXIDATION *B7l2T PAGE 342-944 MiMniS>C*I PtAinRT II BIOCHCN GEN MOL R10L 4N* B1C0VSKY L MORELtO A glutathione dependent oegraoauon of z 2 di CNLOROVINrLDlMFTMtL PHOSPHATE BY THE RAT/ Insect icioe *toub *Azm PAGE 103I-IQ37 ***************.**...*.****** n i iNt ttot. oc*Mt anil icoitii .hoc.** iumtioptf im *-- * I A HUMHSO. 4 AAAI tttttC R00(LINS AAOJfCT .AIL1H1MAR. M0WE1S Rf.tWT HACRBII A RUTRUHT SVtHgMl "UIAlfNT/ AllTAAtT NC-n)R USA RHTTO FLAN,TON HURAN MORASS RUM1CHTS --OSFMOAl/S RITAOOfN CAA.OR GAS SfNAGI fTTJTST. "TnAONAO fSAAT] ** .1 JOtHIR AIOFHVS Rtf CORRUR " >MJ (Rarg t ,, II!!" * oioxe 0M giours or MtassRCs tr rirto tSrELM*V*s *s*tidrshir uith aigosori OISSOCIATIOR/ NRSOAOAUST SROG CONST JTUtRT ..Tm I!" re LUC TEA G ALE IN A tIIilI,.. `.Iorissoat/r RfACUAt or rroretr strthmis in aat 0 s RISFIi R C *`*'US Of A10ASSAT IN THE DETEARIN4TION Of INSECTICIDE 'SIDUES/ "OSOfRIiA.RELANOGASTEA OARMAIA DOT HC -SOE.S **0TJl . U-il, IA -^ . ','J''CIOES (BOMBAY* S*1 TOXICITY or ALORfM ANO UtATHIDK lit lUMitO CALVES/ THESIS ABSTRACT *304002 -121755 PAGE 24 J RYOtO PREFECT UNIT MED 0 14)* INTI 4440 TOGURA N NIIYA ft NAftAI K FURUXAUA S TONOt A tINUMA J INOUC Y 01SMI S ftOBAYXSH! M A CASE OF TUMORS OF THE LIVER ANO SPLEEN IN CONJUNCTION KITH CHRONIC ALCOHOLISM AND DIABETES/ ABSTRACT FIBROSIS CELL VACU0U2ATI0N >44174 PAGE 19# tetHlIHietftMIHHHItnHfimtMfHfftWeiHtlHHHMHMHnUHHI TOXICOL APPl PHARMACOL 14 <21* 1471 9441 ALAN # t SAPQROSChCTZ ( EPSTEIN S S BIOSYNTHESIS OF NtTROSO PIPERIDINE FROM NITRITE OR NITRATE AND PIPERIDINE IN The SNAU INTESTINE QF THE RAT/ ABSTRACT CARCINOGEN *933733 -14T974S0 10Q?S4 PAGE 344-3*5 4442 DOUGHERTY M j GOLDBERG L COULSTON F THE EFFECT OF CARBARYL ON REPRODUCTION IN THE MONKEY RACACA-NUL ATTA/ ABSTRACT TERAT0GENCS1S *43292 FACE 344 9443 SANTOLVCITO J A HASSAN A HH1TCDNB R OBSERVATIONS ON THE ALTERATION BY CARBARYL OF SMOOTH MUSCLE FRIPARATION RESPONSES TO NOREPINEPHRINE/ ABSTRACT RAT RABBIT ADRENERGIC RECEPTORS UTERUS INTESTINE 43242 PAGE 944 9444 CHIN B M SULLIVAN L J> COMPARATIVE METABOLIC PROFILES OF CARBARYL BY KtONCY LIVEN ANO LUNG OF THE DOG ANO RAT USING AN ORGAN MAINTENANCE TECHNIQUE/ ABSTRACT *43292 PAGE 349-344 9449 LUCRE R ft BARQN R L THE METABOLISM OF CARBARYL 1 MAPHTHYL-N-MCTHVL CARBAMATE IT TOBACCO-D CELLS IN SUSPENSION CULTURE/ ABSTRACT *43292 PAGE 344 9444 MURPHT 3 0 CHEfVCR ft L INHIBITION OF RAT TISSUE CARBOXYL ESTERASES AND CHOLIN ESTERASE IT ABATE 0 0 0 0 TETRA METHYL-0 O-THIOOI-F-PHEMYLCNS FHOSPHOROTHIOATE/ ABSTRACT PESTICIDE -44B4T PAGE 344-347 9447 MOOAft A BARLEY L UCINTXAUB S STAVINOMA U B THE EFFECTS OF ClflOMIC OISULPQTON TREATMENT ON THE CHOLIN ESTERASE ACTIVITY OF THE RAT/ ABSTRACT *244044 PAGE 347 944* RAMA SASTRY B V SULFHYORYL GROUPS IN THE VICINITY OF MAMMALIAN CHOLINERGIC RECEPTORS and THCIR implication IN the toxicity op mercurials/ ABSTRACT RAT NEURO MUSCULAR TRANSMISSION *74*49 PAGE 34# 9449 SHERMAN M THE TOXICITY OF StOURON A SUBSTITUTED UREA HERBICIDE/ ABSTRACT RAT DOG PESTICIDE *42B79 PAGE 34B 9470 LAHAM S METABOLISM OF A ME* CARCINOGEN RELATED TO BENZIDINE/ ABSTRACT AAT 3 METH01Y BENZIDINE *94239 - PAGE 341-949 9471 RMERA ft S HUSTON B L NCftINLET V P PRC NATAL AND POST NATAL STUDIES ON 2 4 9 Tft< ChlOROPNCNOxY ACETIC-ACID 2 4-9 AND DERIVATIVES IN Ml STAR RATS/ ABSTRACT PESTICIDES >94797 -93769 PAGE 364-370 9472 KENNEDY G ARNOLD 0 REPLINGCR M L CALANORA J C MUTAGENIC ANO TERATOGENIC STUDIES NtTN LUO ACETATE ANO TETRA ,,ETHYL lead/ ABSTRACT MOUSE -TB0D2 -1441*5 PAGE 370 9479 MCCARTHY J F FANCMER 0 C KENNEDY C L REPLINGEB M L CALANORA J C ,, REPRODUCTION AND TERATOLOGY STUDIES UITH THE INSECTICIDE CARIOFURAN/ ABSTRACT DOG RAT RABBIT *97443 FAGt 3tO 9*74 LOEHR R P COX 6 E CARSON S RtIMER 9 M V0G1N E ( MUTAGENIC STUOICS HtTH 4 AMINO NlCOTtNANlDE IN RATS/ ABSTRACT >74431 171 56M SISG4 A R LA*R`)C M H <U7fAV J ^ TAAT0GENJCITV OF A 0OuP OF PHTHALATE ESTERS TN RATS/ ABSTRACT POLY VINYL CHLORIDE PLASMCUER -1)1202 PAGE 372 5*74 NIBEAG G 9 SAMSON J M COlOkElL S B TRENhOLN H L EFFECTS OF BARBITURATES ON ETHANOL ELIMINATION IN THE RAT/ ABSTRACT -4*175 PAGE 373 56TT COLOMELL BB TAENM1LN N L THOMAS B H UIBERG G S EFFECT OF ETHANOL ON ThE DISTRIBUTION OF PHENO BARBITAL ANO PENTO BARBITAL IN THE RAT/ ABSTRACT -4*175 >7*7*4 >50066 O LI 2531 **t WILSON i J POLY CHLORINATED 81 PHENYL ABSORBED FROM SEDIMENTS 8r FIDDLER CRABS AND PINK SHRIMP/ NOTE AROCLOR-125* PEnAEUS-DUOMARUN PfNAEU$-STIFERU5 PENAEUS-AZTECUS HEPATQ PANCREAS UCA-HlNAX UCA-PUGILATQR RACE Sp-51 *075 WtLSON 8 J tAMD ore 5QYD N R HARRIS T N A LUND EOEMA FACTOR FROM HQUL0V SV6ET-POTATOIS-0 fPOROEA-BATATAS-O/ NOTE MOUSE HUNAN A tPONCANQL FUSiRIUM-JAVANICU* RACE SI-53 *078 STONE 0 NATALRA PULASKI 8 00 ARTIFICIAL SWEETENERS INGESTED IN PREGNANCY AFPECT THE ' < OFF$PRINC/ NOTE HUNAN RAT CYClAMlff 8RAJN DAMAGE MENTAL RETARDATION DOWNS SYNDROME PHYSICAL ANOMALY BEHAYIQRAL PROBLEM* *100888 ' " RAGE S3 R0T7 NAOORELL 5 H CASIO* J C MECHANISM OF INSECTICIDE INDUCEO DIURESIS IN AmOONIUS-PROUIUS/ NOTE DOT AlORIM OICROTORHOS IECTRAN ALLEThr(N NICOTINE LINDANE NALRIGHtAN TUSULES HENOLTMRh PARALYSIS DESICCATION DIURETIC HORMONE MESOTHORACIC GANGLION *8*115 *11918* *50289 508002 *MX|01B120 -91888 *9715782' RAGE 85-5* >*******< ROL REV RADIOL NUCL MED TTTO (55002-*!* \8T0 *07| BICLECRl M IWASZRIEWfCZ J JORDAN J RUN t CM R IVCMUNTOwlCZ Z * THE CINE ROENTGEMOGRARHIC PICTURE OF SWALLOWING AFTER CHEMICAL BURNS OF THE ESOPHAGUS/ HUMAN ANTIBIOTIC CORT1COIO RAGE 757-7*5 - h' UMSCH WISS TECH 71 111, 1871 *070 FALL M XMStCTlttOl SYNERGISTS/ *_.^R1F(R0MU IUT08IDE METABOLISM INSECTICIDE TOItCITf tNHfttUON / DEGRADATION *5109* " RACE 27 ****************************** WEIN-WISStNSCHAFT 24 (8-LOU 1871 *OfO LCMPERLE E KERNER f WAI8EL * DETERMINATION OF RESIDUES OF EFFECTIVE MATERIAL ANO STUDY OF THE FERMENTING BEHAVIOR AFTER USf OF BOTRfTICIDES IN VINICULTURE/ * ORARI-O JUICE *0TRYTIS-IMR(A ..................... FACE 28T-1H MEO J TTTO (5*000-13* 1*70-1*71 *081 6ANULIN S NEW APPROACH TO THE TOXICOLOGY OF PLY AGARIC/ YRIMAN AMANl TA--MUSCARIA MOUSE PACE 17-25 MHI***H*l****ti*M*nt**fU*Mtft**HM|**HM*****Hf BULL M Y ACAD MED *7 110). 1871 P0f2 \ 6AMGARQSA E J THE (RIOEMtOLOGY-OF CHOLERA PAST ANO PRESENT/ VACCINE CONTAMINATED WATER FOOO HISTORY PAGE 11*0-1151 ARH HIG RAO TOKSIKOL ' 20 ISURRI *3. 18*8 0*1 TREPCA WORK ZVECAN YUGOSLAV ASSOCIATION ON OCCUPATIONAL HEALTH INTERNATIONAL SYMPOSIUM ON LEAO POISONING ZVECAN YUGOSLAVIA JULY 17-18 18*8 *7*851/ AGE 1-127 P08* STANKOV1C M POLFTI 0 STAStC 8 PITN0V1C L CONTROL OF LEAO IN THE AIR SIGNIFICANCE FOR EXPOSURE TO ANQ PREVENTION OF LEAD POISONING/ ``WORKERS >7*891 PAGE 1-B .*** - *085 KING E PARAMETERS of LIAO ABSORPTION/ INDUSTRY *T*851 PACE 8-U 01* FOWLER 0 G control of industrial exposure to veao in the us* -tmsi/ *g* n-t* POdT MALi^C'. - A AN ASSESSMENT OF TmB VALUE OF LA8C*ArPY INVESTIGATION fN TNf DETECTICN ANO CONTROL CF LE0 PQISQMNG/ WORKER CORK* PQRPnvAIN TEST 7*851 PAGE 18-22 POBB CRANE* K ,, RELATIONSHIPS BETWEEN THE CONCENTRATIONS OP LEAD in blooo and DELTA AMINO LEVULIC-ACIO IN U*|N( DURING LEAD EXPOSED WORK iL (VoL 1 Ha. Cj *7*851/ RAGE 29-90 *088 STOPRS A j AMINO LEVUL1N1C-ACID IN THE EVALUATION OF LEAD EXPOSURE/ WORKERS *7*851 RACE 11-91 *090 OE BRUIN A EFFECT OF LEAD ElRQSURE OH THE LEVEL OF DELTA AMINO LEWLlNIC DEHYDRATASE ACTIVITY/ WORKERS ROARHYilNt *7*891 RAGE 3 S'* 2 *081 HOLMQVIST 1 BLOOD LEAD DETERMINATIONS IN CONTROL OF EXPOSED WORKERS 7*891/ RACE *9-*7 *082 WILLIAMS M K A METHOD FOR ESTIMATING THE COMPARATIVE MERITS OF THE BIOLOGICAL TESTS OF LEAO EXPOSURE *T*5L/ RAGE *8-59 *081 PRPIC-NAJtC 0 SEMITIC T VUROELJA I xersanc e RELATIONSHIP BETWEEN LEAD IN THE BONl NARROW AND LEAO IK THE BLOOD/ WORKERS *7*151 RAGE 59-57 *08* STANKOVIC M RETROVIC L ROLETI 0 ASSESSMENT OF THE VALUE AND INTERRELATIONS OF BIO TOXICOLOGICAL ANALYSIS OF URINE IN WORKERS WITH CHRONIC LEAO EXPOSURE *7*951/ RAGE `59-** *095 SCHLEGtL H PRACTICAL VALUE OF DIFFERENT SCREENING TESTS tN THE CONTROL OF GREAT NUMBERS OF WORKMEN WITH EXPOSURE TO LEAD IN THE AUTOMOBILE MANUFACTURE *T*B5I/ PAGE *7-70 *08* momajEnrova A m CARO10 VASCULAR SYSTEM IN LEAO POISONING/ HUMAN -7*851 PAGE 71-79 .. *087 GRAOVAC-LEROSiVtC L OOQIC S ACCIDENTAL LEAO POISONING. IN A P4M(LT/ CHILDREN ADULTS LEAO BULLETS *7*151 PAGE 77-12 *08* MARKICEVlC A IEPITIC T . ON THE HEPATO TOIJC ACTION OF LEAD/ HUMAN 7*851 PAGE B>-8 *088 BAOONfC N 2URANIC V SABIC M HISTOLOGICAL CHANGES OF THf KIDNEYS IN LEAO RQISOMMG/ HUMAN *7**91 PAGE 85-88 *100 PRPIC-NAJIC0 BARIC M VUROELJA * BERITIC T MARKICEVlC A KERSANC A OUR EXPERIENCE WITH THE TREATMENT OF LEAO POISONING WITH CHELATES/ HUMAN EOT* CQMRLfXONf AMTtDQTE-DMuG *7*151 **02P PAGE 88-111 *101 VAS1LJEVIC S KALIC-FtLSPOVlC D ANDELOVSKl 4 EXPERIENCES IN ORAL ANO PARENTERAL APPLICATION OR CALCIU* 0t SODIUM EOTA/ HUNAN ANTIDOTE-DRUG INDUSTRIAL MAZAROS *B9|9* PAGE 119-121 *102 DORIC D MILIC s BOJCVIC V GRlOVAC-LEPOSAVtC L URINARY EXCRETION OF ZINC IN WORKERS EXROSEO TO LEAO TREATED WITH CALCIUM 0! SODIUM EOTA/ ANTIQOTE-ORUG *7*851 *7**D** *1200228* PAGE 129-127 , C R HEED SEANCES ACAO SCI SCR C SCI CHIP (PARIS! 271 It*). 1870 *101 BR1CARD J CABAKf M NADlLAINf G VlGLA D FORMAT!(M OF RHOTQLVTfC PARTICLES |N TMf AIR/ AIR POLLUTION , PAGE 7*7-780 LANCET 2 (7***1 * 1870 *108 LOGAN R F L ORANGE PALMS IN LANCASHIRE/ LITTER ENGLANO HOUSEWIVES RAW CiRRQTl-Q EXCESS CAROTENE SWEAT glano EXCRETION PAGE 151 *109 JAEGER R J RUBIN R J ' CONTAMINATION CF BLOOD STORED IN PLASTIC PACKS/ LETTER RAT Of OCTYL PhThalATE PLASTICIZER POLY VINYL ChlOMDE TUBING *PM9002IA2 *1178*0 a PAGE 151 , *10* HOWELL R W SMOKING HABITS AND LABORATORY TESTS/ LETTER HUMAN ..... , ... , PAGE 152 *107 WEISS H J RATTLESNAKE BITE/ LETTER human CROTALUS-AOAMANTEUS THROMBIN-LIKE eppect PAGE 15* ANN 1NTfN "ED '5 5I, 1871 LICHTfNSTElw l M HUMAN EX!R {MENTATION 9V INDUSTRY THE CASE OF t NZVaf DETERGENTS/ MEtEOITOKIAL TOXICOLOGY QLI 2532 457 [July, 1972] cell cavities, squamltizatlon of the follicle epithelium and decrease In the number of follicle cells. When vitamin E was given to these mice together with Cd water, these regressive changes were Inhibited some what.-*K. P. 5216. N1SH1ZUMI. M. Electron microscopic changes following administration of heavy metals. JAP J CLIN PATHOL 19(1): 42-45. M 1971,--Rats were given drinking water containing CdCl2 for 2 wk-12 mo. The following tubule cell changes were observed electron-microscopically; Increased mlcrobodies, changes in the mitochondria, and increased lysozymes. When rats were given water containing PbfCHjCOO);, similar changes occurred. When HgCl} (30 mgAg) was injected sub cutaneously into rats, mitachoidrlal crlstae became like cellules. Mitochondrial destruction was also observed.--K. P. 5217. MATSUMOTO, H. Metabolism and determination of lead In lead poisoning. JAP J CUN PATHOL I9(i): 56-62. 1971.--Urinary M caprophyrln should be qualitatively as well as quantitatively determined O to detect Pb poisoning In humans. Urinary Pb level (over 33 ug/L) and blood Pb level (over 17 pg/100 ml) should be used to supplement the ccprophyrln level test. Persons exposed to occupational, medicinal and other sources of Pb showed higher levels of Pb In the urine (150 jig^Lj and blood (60 ug/100 ml).--K. P. M 5215. HOTTA, S. and S. OSAJIMA. Chronic cadmium poisoning. JAP J CUN PATHOL 19(1): 46-50. 1971.--Studies on renai tubular malfunctions In humans caused by Cd poisoning are reviewed.--K. P. 6219. HUBER. 0. L. and F. M. LA FORCE. Comparative effects of ozone and oxygen on pulmonary antibacterial defense mechanisms. A ANTIMICROBAGENTS CHEMOTHER 10. 129-136. 1970.--To B determine the effect of 2 environmentally and therapeutically important G oxidants, Oj and O2. on pulmonary defense mechanisms, bacterial clearance was evaluated by quantifying bacterial inactivation In the lungs of 2500 mice after exposure to an aerosol of radiolabeled ("F) Staphylococcus aureus. Controls Inactivated 92 2$ of Inhaled bacteria. 63 administration resulted In diminished clearance directly related to the level 6f oxidant exposure: 65 a 2% Inactivated after exposure to 0.1 ppm of O] for 3 hr, 72 a 4% at 0.5 ppm, and 45 a 7% at 1.0 ppm. After prolonged exposure to 100% 02, clearance diminished in direct relation to duration dl exposure: 87 a 4% inactivated after 12 hr. 79 a 2% at 24 hr, 69 a 3% at 48 hr, and 56 a 6% at 72 hr of exposure. There was a similar dose-response depression of clearance at lower 02 con centrations. Electron microscopy alvelor macrophages harvested from the lungs of mice exposed to both oxidants revealed in progressively increasing numbers ultrastructural alterations characteristic of cellular Injury. These studies Indicate a progressive, dose-related functional depression In Intnpulmonary antibacterial defenses and structural alterations in alveolar macrophages after exposure to an important and frequently used therapeutic agent, 02. and a similar dose-related depression In bacterial clearance and altered macrophage structure after exposure to s common air pollutant, Os. at levels frequently found In our envinmment.--S. R. p. 5220. LENOIR, L. F., P. H. MULLER and O. M. LENOIR. Biological 2 approach to the acute alcoholic state. LILLE MED 15(5): 759-764. 1971.--Studies of blood alcohol levels of multiple subjects, as ihosn by routine tests at the time of various legal Infractions, In correlation with clinical symptoms showed the Importance of such tecta in enrlfer detec tion of latent alcoholic conditions. Such teats can sometimes explain a certain number of psychoaffective disturbances, states of Instability, clumsiness, highway accidents or accidents at work, and the Ineffec tiveness of fertain treatments. Although alcohol effects were propor tional to Modd alcohol levels, this progreeeltm was neither absolute nor constant, being especially subject to change after the age of 25. The study also revealed an exceptionally high tendency of subjects with a Ugh blood alcohol level in 1 test to have high levels In subsequent tests. With reference to the Mghways, the number of drivers driving with s high blood alcchol level was found to be considerable; of 20% of the drivers who wars subjected to systematic tests, 20% presented excessive levels.--S. L. R. 5221. SANZ SANCHEZ, F. Mvcotoxlna and their public health B F U Impliestlma. AN R ACAD NACL MED (MADR) 88(2): 31I-JSJ, 1971.--The literature on mycotoxlns lc reviewed. These poisons are generated by many types of fungi, which sometimes art known to have developed on poorly stored foods or feeds, e.g., cereals. In isolated 2 eases they have caused poisoning symptoms In animals and man. The best known outbreak occurred In turkeys, In England, due to groundnut meal contaminated with an a/latoxin produced by Aspergillus flavus. Numerous cases of human disease In Japan ware traced to 'yellow rice,* In which the mycotic metabolite was produced by various species o/ FcnlcllUum and AmerclUua. In screening the metabolites of an ex tensive scries of molds for possibly useful antibiotics, a large variety of molds vers fouixl to generate metabolites poisonous to laboratory animals. The chemical structure of these mycotoxlns and the fungi that generate them are systematically reviewed. It Is thought that some these poisons might be harmful to man, possibly contributing to cancer, hence discouragement of the distribution of mold-contaminated foods is recommended.--P. H. V. t. n 5216-5225 6222. BORGHETTI. A., A. CAVATORIA, A. DAL CANTON. I. FRANCHINI. T. M. NERI and A. NOVARINI. Formulation of biological Indexes for epidemiological studies of exposure to lead poisoning. G LIN MED 52(4): 234-246. 1971.--Biological exposure indices lor the risk of Pb intoxication were derived by determining the concentration of delta-aminolevulinic acid and caproporphyrtn, and by analyzing the lead creatinine level, urine osmolartty, and diuretic volume.--S. R. P. 6223. TEICHMANN, B,, W. GIBEL. T. SCHRAMM and K. LOHS. Preventive medicine recommendation for work with chemical carcino ids; "Aftea's^kwuUTpaftscn swr nr-ste, ii .-Legal meaeurea concerning the protection of employees from exposure to carcinogens and the dangers which may result form working with chemical carcinogens art discussed. A series of Important groups of substances containing carcinogenic compounds are chemically char acterized and their mode of action is studied. Protective measures are proposed for all types of handling (e.g., production, measurement, biological testing preservation, transport, destruction) of these carcino gens. Demands made upon laboratories and clothing, the qualification of employees, medical supervision of endangered persons and instruc tions on possible endangers of working with carcinogenic substances are also pressntsd.--S. R, p. 6224. GIBEL, W,, K. LOHS, G. P. WILDNER art D. ZIEBARTH. Animal experiments studies on hepatotoxlc and canceroeenlc activity of organophosphorua compounds: I Trlchlorphon. ARCH GESCHwUlSTFORSCH 37(4): 303-312. 1971 .-Long-term studies of rats and mice given trlchlorphon revealed severe liver damage associated with heavy steatosis, ntcrosls and cirrhosis formation. Liver tumors were observed in 2 cases. In addition, a number of papillomas formed In the forestomach and a local sarcoma was found.--S. R. P. 6225. SCHIECHE, M,, M. KESSLER and S. KOBER. Date on sickness In a blast furnace steel plant. Z AERZTL FORTBILD (JENA) 64(11): 614-621. 1970.--Personnel directly engaged In blast furnace, operations (In Germany), despite their exposure to occupational hazards of heat, burns and noxious gases, had a better record of freedom from Illness and accident* than other personnel from the same enterprise. This Is because blast furnace operators are selected mainly from the 25-39 age group, are predominantly well trained men, work under goad discipline and organization, and have a high sense of personal responsibility; in addition, their work is surrounded by special safety precautions. CO poisoning cases have steadily declined, and there has been no fatal case since 1955. Illness in all departments tended to Increase In spring and to decline in summer. Colds and accidents claimed the larger number of cases of disability, followsd by digestive disorders. However, periods of disability were longest for cardiovascular and respiratory diaeasea and reproductive disorders. Disability casta mounted In the higher age groups.--P. H. V. I. 6226. GROSSER, P. J. Studies on parallel Child groups with consider ation of air hygiene aspects. I AfeftZTlTRlfrrBlLD (JENA) 64(9): 463-466. 1970,--Factors Involved In using parallel groups of children to study air pollutant effects on tht general population are discussed. A study using 340 children was employed as an example. Children are highly suited for these tests because other factors (smoking, occupa tional stress, general living conditional have not Influenced them to 1 great extent. In these studies children are from basically similar socio-economic backgrounds. Parallel groups are bused on sge, sex, number of siblings. lnJtvIdualn/room Index and number of consumer goods owned by the family. Immlsston values for tha areas studied must be known for all toxic substances studied and for comparative purpose* the areas studied must show wide differences In these values. Characteristics studied Include height, weight, blood pressure, white blood count, red blood count, erythrognun, total protein, alkaline phos phatase in serum and serum properdin* level, vital capacity and X-ray of th4 left wrist. Results of the study mentioned art presented else where.--S. K. J. 6227. MUSCHTER. W. and P. SMOUNKA. Studies on the aspiration 1970,--Studies oi SOg and total lmmlaslon particle (car, home and factory exhausts) concentrations at 4. 40 and 75 m were made In Berlin. In both cases concentrations wars lower at the higher levels. Differences were significant between the 1st and 2nd and 1st and 3rd levels and in significant between the 2nd and 3rd levels. Meterologlcal factors (wind speed end temperature) which effect these concentrations at the various heights were discussed. With decreasing wind speed there is an In crease of the concentrattens at higher levels. This Is also true of CO. -S, K. J. 8228. ZENK. H. Occupational vestibular damages. Z AERZTL FORTBILD (JENA) 64U3>: 676-678. 1970.--Diagnoses of vestitailar nerve reactions to industrial poisons by means of combined caloric, rotational and. positional testa, and the measurement of nystagmus are presented. The vestibular nerve ties In with the nystagmogenic zone In the bratn'stem; where peripheral stimuli are transformed into oculomotor Impulse*. The resulting nystagmus may be the only ob jective method tof Confirming the dizziness of which the patient OLI 2533 I ; *584-6591 n [Vol. 1 No. 7] 494 wk Old and the lemurs of 16-day. mouse embryos or newborn mice. With these stains, It was possible to distinguish 3 types of proteoglycans or materials associated with them, which may have, as their major dif ferences, the type of cross linking to the tissue. One type was stained by ruthenium red and protamine but not by lysozyme, was extractable with J M GO [guanidinium chloride] and was relatively uniformly dispersed throughout Hje matrix of the growth plate. The other 2 types were stained by all 3 cations, were not extractable with 3M CO and were in lnltimately associated with fibrils. One of these way found on the colla gen fibrils, was relatively scanty in the resting zone near the articu lar surface, relatively restricted to the extralacumar area In the colu mnar zones and appeared to dimtsh in amount in the hypertrophic zone. This material often had a 640 A periodic array on the surface of col lagen fibrils. The 3rd type also was stained by all 3 cations and was not sctractable with 3 M GG. It was distinguished from the other class of lysozyme-reactive matrix components by the larger volume of dis tribution occupied by the stained material. It also had a different dis tribution in that it was widely dispersed in the resting zone, was restricted to the lacuna In the columnar zone and was absent in the hypertrophic cone. Thus, cartilage matrix and chondrocytes undergo differentiation in the epiphyseal growth plate. 6584. FOREST, H. S. and E. L. MILLS. (State Unlv. Coll., Geneseo, K, Y., USA.) Studies on the plants of the Genesee country (western New York State). Vi. The aquatic flora of Conesus Lake. PRQC ftQCHESTfift AtAtTSCl 12(2): 116-138. nlusT.Viaps. 1671[recd. 1972].-- included in the ecological consideration of the lake are: a study of the sewage Increase and Us relationship to coliform counts and the pollution of the environment and an analysis of the pattern of p content and distribution In the lake. Preliminary distribution data and quantitative community analysis at the flora, Including 26 genera and 43 spp. of angioepernts, are preeented and discussed. --N. F, G. esas.' BROSSET, A. (Lab. EcoL Gen. Mus., 4, Ave. Petit- Chateau, 91-Brunoy, Fr.) Quelques observations de prtntemps au Cap Bon (Tunisit). [Some springtime observations at Cape Bon (Tunisia),] ALAUDS 39(3): 223-226. 1971,--Previous lists of the raptors taken by falconers in Tunisia did not give an exact idea of the numerical ratio of species passing by Cape Bon. The raptor found to be the most abundant migrator at the beginning of May 1971 was Pernls apivorus; considerable north-south flights succeeded one another without interruption on the slopes dominating El Haouarta. The 2nd most frequent species was Falco subbuteo. Birds caught from the beginning of April to the ldth of May and observed in the hands of the falconers were Accipiter ms us, Hieraaetus pennants. P. apivorus. Buteo butto. Circus macrourus. C. pvgargus. S7~ ruflnus ruTmus] FT subbuteo^ F. vespertinus. T7 columbarius. F\_ tlnnunculus, F. naumanni and F, elconorae] The northern migratory subspecies BTbuteo vuiotnua was observed passing by Cape Bon but the specimens were gray without the reddish feathers normally characterizing the subspecies. Therefore, populations of the sub species vulpinus with grayer plumage exist and winter over or pass through particular regions of Alrlca including Cape Bon. With re gard to the most sought after raptor, the sparrow hawk, the falconers were unanimous in their evaluation of the migratory populations over the last 1$ yr : towards 1930 there was a considerable drop, perhaps 95%. This observation is significant because a sudden drop in spar row hawks in many regions of Europe was also noted around 1950 and cotncldedswith the beginning of massive use of agricultural pesticides in these regions. As for the sedentary raptors of Cape Bon, F. peregrinus has retained an apparently intact population. Other species observed were Lana audoulni. which was observed off Cape Boo, and Bucanetes gtthagineus, for which the Cape was an area far north of its area of distribution.--5. L. R. 6586. TR1NCA, J. C. (Commonw. Serum Lab., 43 Poplar Road, Park- villt, Victoria, Aust.), J. J. GRAYDON, J. COVACEVICH, and C. LIMPUS. The rough-scaled snake (Tronidechis cartnatus): A dangerously venomous Australian snake. MED J AUST 801-&09. Mus. 1971.-- A comprehensive study was made of the natural distribution and venom effects of T. carinatus. a little-known species which is not generally regarded as dangerous to man. Laboratory studies and the effects in animals, and In 12 authentic cases of human bites, with 1 fatality, show that the venom of the rough-scaled snake is comparable in toxicity to those of the better-known dangerously venomous Australian snakes. Its pugnacity when provoked and its unpredictable temperament make it a snake that is best left alone. The distribution of positively identified specimens shows that it is located in the coastal areas of northern New South Wales, southeastern Queensland and north-eastern Queensland. Its apparent absence from large areas of coastal, central and far northern Queensland is attributed to its liktnc for relative!,- cool, moist tMns. -A. 5. M. 6587. SINGH, A. R,, W. H. LAWRENCE and J. AUTIAN. (Vniv. Tenn. Med. Units, Memphis, Tenn., 38103, USA.) Teratogenicity of phthnlate esters in rats. J.PHARM SCI 61(1): 51-55. 1972,--Small quantities of phthalatea.may be released from polyvinyl chloride items to physiologi cal solutions. To ascertain the effect these plasticizers might have upon the fetus, a teratogenic study was undertaken in rats using 8 phthalate esters. Six of the phthalates, whose acute intrapentoneal LDjq values were below 10 ml/kg, were administered to rats at doses representing 1 .'10, 1 /5, and 1/3 of the acute LDjg dose on the 5th, 10th, and 15th day of gestation; the 2 less taxie compounds were injected at levels of 5 and 10 ml/kg. Distilled water and normal saline were tested at 10 ml.'kg, and cottonseed oil was tested at 5 and 10 ml/kg. Untreated animals were used for control values. The number of corpora lutea ranged from 52 to 65 per group of 5 rats, with no apparent distribution according to treat ment, Embryo-fetal toxicity ranged irom 0% to a high of 98.2%. Fetal malformations ranged from 0 to 100%, both for gross and skeletal abnor malities, with skeletal defects generally being more common. Fetuses from all phthalale-treated groups were smaller (p < 0.01) than the un treated controls. Absence of tail, anophthalmia, and twisted hind legs were the most common gross abnormalities, while elongated and fused ribs and abnormal skull bones were the most common deformities found In stained skeletal specimens. 6588. COURTNEY, K. DIANE (Perrlne Primate Lab., Perrine, Fla., 33157, USA.) and JOHN A. MOORE. Teratology studies with 2,4,5-tnchlorophenoxvacetlc add and 2,3.7,8-tetrachlorodibenzo-P-dioxin. TOXICOL APPL PHARMACOL 20(37: 396-403. 1971[recd. 1972 j.-The herbicide 2,4,5-trichlorophenaxyacetic acid (2,4,5-T), and 2,3,7,8-tetrachlorodibcnzo-p-diaxin (TCDD) were teratogenic in the CD-I, DBA, 2J, and C57B1/6J strains of mice. Both compounds produced cleft palates and kidney malformations. When these compounds were administered in combination, the activity was not potentiated at the doses employed. In the CD rat, 2,4,5-T was neither teratogenic nor fetotoxic. However, TCDD produced kidney anomalies. Prenatal administration of 3,4,5-T did not affect the postnatal growth and development of the CD rat. p z 6589. AGNEW, WILLIAM F. and JUNG TA CHENG. (Huntington Inst. AppL Med. Res., Pasadena, Calif., 91105, USA.) Protein binding of tellurium-127m by maternal and fetal tissues of the rat. TOXICOL APPL PHARMAdbL 20(3): 346-356. Illus. 1971[recd. 1$72|.--In vivo and in vitro metabolic studies with tellurium-127m have demonstrated by the use of several isolation procedures that Te is tightly bound to feta] and maternal soluble proteins of the rat. Studies on whole blood have shown that Te is bound uniformly to all serum protein fractions, and that the binding process appears to be dependent on the presence of a red blood cell enzyme. Binding of Te in soluble proteins of plasma and brain is inhibited by p-chloromereuribenzoate (PCMB). A detoxification function for the tellurium-protein association is proposed, and its possible rela tionship to the induction of congenital communicating hydrocephalus in the rat is discussed. 6590. SASAKI, KENICHI. (Dep. Pathol., Hokkaido Univ. Sch. Med., Sapporo, Jap.) Histological changes of the liver in Eck's fistula dogs following copper administration wuh special reference to hepatic coma. HOKKAIDO J MED SCI 46(j): lfll-Tlj. Illus. 1971. Iln Jap, with Enel, summ.?--Hepatolenticular degeneration is characterized by the appear ance of the Cu granules in the liver and brain stem; cirrhosis is also observed. As Cu administration alone never produces hepatic cirrhosis, a relationship between abnormal Cu metabolism and cirrhosis was sought. Liver injuries and a marked histological changes, mainly degeneration, were seen in the brain stem at Eck's fistula dog suggesting circulatory disturbances in the liver to be an important factor in the development cf hepatolenticular degeneration. The effect cf Cu administration io the Eck's fistula dog was investigated. Cu administration for 1 yr caused no significant change in the liver except for the vacuolar degeneration of hepatic cells. The administration of Cu for 5-7 mo. to the Eck's fistula dog (1 mo. after operation) caused fatal hepatic coma accompanied by a marked jaundice. Histologically focal and extensive necrosis, faity de generation and irregular proliferation of connective tissue fiber were seen, indicating the initial picture of postnecrotic hepatic cirrhosis. A diffuse appearance of Cu granules was seen in the hepatic cells of Eck's fistula dog. The impairing factor of the liver itself and the intoxicating action of Cu is probably required for the development at striking histo logical changes and Cu deposition in the liver in relation to the abnormal Cu metabolism. A hepatic circulatory disturbance is a possible impair ing factor and might also be responsible for the development of coma. --J. G. M R M 6591. 1WANCZUK, IRENA and JADW1GA KELUS, (ut. Choeimika 24, Warszawa, Pol.) Wplyw ch/oru i jodu czynnego na przezywalnosc jaj robakow jeiitowych cz)bwieka: Ascartua lumbrlcoldes i enterobus vermicularis- w basenach Kaplelowych. (The influence of active chlorine W and iodine on the viability in swimming pools of eggs of human intestinal hclrm.-rhs Ascans lumbncoides ana Enterobius vermicularis.nCCZ FAN.- il.i.-.L i:iJ J2 2,. 17j-lo7. ii,js. loll. ^ing.. ana (tit, ju.r.m., --Large numbers of eggs of human intestinal heimmtns. muni. Z. ver- miculans and Taema sp.. as well as A. lumbncoides are present in pun- lie swimming pools. An investigation was undertaken on the ovicidal ac tion of 1 and Cl used as water disinfection agents in pools. The investi gation was carried out on the eggs of animal nematodes, in place of the eggs of E. vermicularis, those cf Aspiculans tetraptera were used, ut OLI 2534 685 (October, 1972] JlO 9294-9304 M XO O > NXHOS 9294. LUTSENKO, L. A. (F. F. Ertsmiui Res. Inst. Hyg., Moscow, USSR.) Voprosy gtglcny truda prt obogashchenil sul'fldnykh mednykh rud na fabrlkakh Urala. (Industrial hygiene in the concentration of sullide copper ores at mills in the Urals. I GIG TR PROF ZXclGL 14(10): 11-lh. Ulus, isvu. (fc'ngi. sum.J--Hyglenlc Investigations or 3 mills show that Inthe course of flotatlonal processing of copper ores, the workers are exposed to dust effects from the treated ores and their final concentrates, and to decomposition products of dotation agents (hydrogen cyanide, CS2 and H^S), noise, vibration low tempera ture and an elevated relative humidity. The sullide copper ore dust exerts fibrogenic and a mildly toxic action. The copper-concent rate dust displayed stronger general toxic action than did the ore. The maximum permissible concentration of sulfide copper ore dust con taining less than 101? free silica should be 4 mg/m . Health measures aimed at improving work conditions are given.--K, M. E. 9299, ESTON, P. I. Opyt glgienicheskikh issledovanii pylevogo falitora na shakhtakh Kuzbassa za 1955-1968 gg. (Sovlei experience with hygienic studies of the dust factor in coal mines of the Kuzhetsk basin from l$SS-tfr6&.l GIG TR PROF ZABOL 14(10): 7-11. 1&70. [Engl, sum.]--Investigations covered all methods of coal extraction and excavation of enclosing rocks under diverse mining and geological conditions by using various means of dust control. Functional depend ence of the case-finding frequency and service record prior to recog nition of pneumoconiosis among miners with a service record of 1020 yr upon the factual weighted mean air dustiness during the shift was found and expressed in terms of mathematical formulas. A compara tive analysis of the after-effects of exposure of miners belonging to different occupational groups to an aerosol with a small silica content over the last 15 yr is given. In hydraulic mining of coal the air dusti ness is lower than with other methods of coal extraction,--C, M, M, NXOO Nxo s> 9295. ERAMYAN, S. G.. E. A, AGABALYAN, and D. A. TASHCHYAN. X (Yerevan Inst. Ind. Hyg. Occup. Dis., Yerevan, USSR.) Sravnltel'noe 2 izuchenie ststemy svertyvaniya krcvi prt razlichnykh nespetsifeches- kikh zabolevaniyakh legkikh pylevoi i nepylevol etiologil. (A compara tive study of the blood coagulation system In different chronic nonspe cific pulmonary affections of dust and non-dust etiology. 1 GIG TR PROF ZABOL 14(10): 32-35. 1970. [Engl. sum.J-- The sUte of the blood coagulation system was studied in patients with chronic nonspe cific maladies of the lungs such as bronchitis, emphysema, pneumo sclerosis of non-dust etiology in 43, suppurative diseases of the lungs In 10S and pneumoconiosis in the Cu Industry of Armenia in 48 cases. The nature of disturbances depended upon various combinations and intensity of inflammatory and flbrotie alterations in the lungs. As the degree of respiratory insufficiency and severity of the affection gained in Intensity the blood clotting capacity increased. In patients with bron chitis, emphysema and pneumosclerosis activation of the blood coagula tion ability and of the anticlotting component could be recorded. In pul monary suppurations a rise of the coagulation capacity went with In hibition irf the fibrinolytic activity of the blood. Pneumoconiosis activa tion of the anticlotttng factors and the fibrinolytic system were charac teristic.--S. B. 9296. BODE, C. (Med. Universitaetsklin., Marburg, W. Ger.), ~ CHRIST1ANE BODE, H. GOEBELL. H. GODBERSEN, and G. 1 STROHMEYER. On the pathogenesis of ethanol-induced lipid accumula tion in the liver: TIT Effect of stimulation of the o-glvcerophosphate cycle on metabolic changes in metabolic changes in the liver caused by ethanol. ROHM METAB RES 2(5): 282-286. Ulus. 19'iu.-- The ellect of hyperthyroidism Induced by L-triiodothyronine upon the oxidation of ethanol and ethanol-dependent metabolic alterations was Investigated in male rats. Hyperthyroidism reduces the accumulation of a-glycerophosphate and the increase of the reduction of the cyto plasmic NAD-systera caused by ethanol. This effect is due to the marked elevation of the activity of or-glycerophosphate oxidase, the rate limiting enzyme of the o-glycerophosphate cycle. The accumula te of triglycerides in the liver by a single dose of ethanol is distinctly less In hyperthyroid rats than in euthyroid controls. In contrast, the production of 3-hydroxybutyrate and acetoacetate is stimulated. The preferential esterification of long-chain fatty adds in the liver to triglycerides following ethanol application is probably partially caused by the Increased a-glycerophosjiiate content. The activity of alcohol dehydrogenase (ADH) calculated per gram of liver tissue, decreases in L-trttodothyronine treated animals. The total activity of ADH per animal did not change significantly because the liver weight increased. The elimination of alcohol from the blood Is slightly elevated tn hyper thyroidism. 9297. VORONTSOVA, E. I., and V. B. LATUSHKtNA. (Inst. Ind. O Hyg. Occup. Dls., Acad, Med. Set. USSR, Moscow, USSR.) Profilaktlka X pnevmokoniozov, (Prevention of pneumoconiosis.) GIG TR PROF Z ZABOL 14(10): 4-7. 197d.[Engl. sum.)--Concrete examples of Individual mines and enterprises, where hygienic requirements were met to the full and the pneumoconiosis incidence greatly reduced, were reported. Implementation of a set of legislative, technological and sanitary-technical measures, medico-biological prophylaxis and per sonal hygiene can secure a still greater reduction of the Incidence of pneumoconioses.--C. M. M. 9296. VERTKIN, Y. I., and Y. R. MAMONTOV. (Leningrad Sanit. " Hyg. Med. Inst,, Leningrad, USSR.) O sostoyanii bronkho-legochnogo X apparata u rabotayushchikh na prolzvodstve isdelil lz polivinitkhlorida. Z (Condition of the bronchopulmonary system in workers manufacturing articles of poivymylchloniie.1 GIG TR PROF ZABOL 14,10): 263i. 1970. (Engl. sum.]--Workers [9ti] engaged in me manufacture 01 articles made of polyvinylchloride were examined In detail. A consid erable number of them had alterations tn the respiratory organs typified by changed bronchovascular pattern and increased pulmonary ventilation at rest. These should most probably be ascribed to 4he effect of adverse factors of the industrial environment and particularly to intensive and long-term exposure to polyvinylchloride dust,--C, M. M. , 9300 . MIKHAILOVA, L., T. BURILKOV, and K. KOLEV. (Inst. Ind. Hyg. Occup. Dis., Sofia, Bulg.) Mineralogicheskoe issledovanle otiozhenll v legkikh pyli i ee znachenie dlya professional'noi patologil. (Mlneraloglcal study of dust deposited In the lungs and its significance in occupational pathology*! GIG TR PROF ZABOL 14(10): 22-25. 197U. [Engl, sum.]--Poaeibilittes of studying and expert evaluation of pneumoconioses revealed through Isolation and mlneraloglcal analysis of the dust retained in the lungs are described. The formamtde method as proposed by Thomas and elaborated further by Elnbrod was employed to investigate tbe pulmonary dust of a furnace constructor with a ser vice record of 28 yr. Clinical, pathologico-anatomic and mlneraloglcal findings are contrasted. Their coincidence emphasizes the value of Independently conducted mlneraloglcal analyses of the dust deposited In the lungs. These investigations acquire particular significance In cases involving inhalation of mixed dusts with low content of free silica. --C. M. M. 9301. PAL'TSEV, Y. P. (F. F. Erisman Res. Inst. Hyg., Moscow, USSR.) Voprosy bor'by s pyl'yu ns teplovykh elektrostantslyakh. (Dust control in thermal electric power stations.1 GIG TR PROF ZABOL 14(10): 15-19. 1970. (Engl. BUm.j--A number of techno logical processes and operations at thermal electric power stations release fuel and cinder dust, whose concentration may be well-above the maximum permissible level, into the atmosphere of work premises. Workers exposed to a protracted effect of such dust demonstrate the presence of chronic disorders of respiratory organs and skin. Acute poisonings are possible following exposure to the effect of high con centrations of the S-rich fuel oil cinder duet containing V and Ni com pounds. To prevent occupational poisonings, sanitary-technical (aspiration and steaming units, sealing-off of the equipment, pneumatic cleaning, hydraulic wash-out) and hygienic (anti-dust respirators, protective pastes) measures were recommended. Introduction of such measures at a number of electric power stations helped to drastically reduce the concentration of fuel and cinder dust m the atmosphere of work premises and to do away with acute and chronic occupational diseases.--C. M. M. 9302. GELDMACHER-VON MALLINCKHODT, M., and H. p. SCHMIDT. (Inst. Rechtsmed., Umv, Erlangen-Nuernberg, Erlangen. W. Ger.) Zur Toxicitaet und Stoffwechsel von Aminotriazol helm Menstthen. (Toxicity and metabolism of aminotriazole in man.] ARCH TOXI KOL 27(l): 13-18. 1970|recd. 1971). [Engl, sum.)--After ingestion of 20 mg.'kg of aminotriazole [a herbicide], a 39 yr old woman showed no signs of intoxication. From a urine specimen taken some hours later, unchanged aminotriazole in an amount of 100 mg/100 ml could be isolated and identified. 9303. PELIKAN, ZEDNEK (Univ. Hosp,, Groningen, Neth.), and EMIL CERNY. Toxic effects of some 'mono-N-butyl-tin comoounds" on white mice. ARCH TOXIKOL 27(1): 79-84. lfl7fl[recd. 197IJ. [Ger. sum.]--The toxic effects of "mono-n-butyl-ttn-trichlortde", 'mono-nbutyl-tin-tris- (2-ethyl-hexyl-mercaptoacetate)-, "mono-n-butyl-tin acid" and "mono-n-butyl-thiottn acid" on white mice were investigated. These compounds were administered by means of a stomach tube in a single dose of 4000 mg/kg body weight, at the start of the experiment. Atl mice were sacrificed 24 hr after admimstration. The clinical course and macroscopic findings in alt experimental groups indicated general signs of acute intoxication. The histological findings in the "mono-nixityl-tin-trtchloride" group showed pronounced changes in the digestive tract, where hemorrhages in the mucous membrane and in the inner layet of the gastric and intestinal walls were found. In other experimental groups of mice, steatosis of the hepatocytes and an irregular steatosis of the renal tutxilar epithelium were observed. 9304 , STEPANOV, M. A., and V. A. POTEKHTNA. (Novokuznetsk Inst, Postgrad. Med., Novokumetsk, USSR.) Sostoyante sokratitel'noi funktsii serdtsa 1 arterial'nogo tonusa u bol'nykh pnevmokoniozom rabotnits ugleobogatitel'nykh fabrik. [Contractile function of the heart and arterial tone In pneumoconiosis-stricken female workers of coal dressing mills. | GIG Tft PftGE ZAfioL 14(10): 25-29. Tllus. 1970. |EngL sum. I--Results of a ballistocardiograph [BCG] and oscillography OLI 2535 N S N -o NXO ' .1 Y.i ~4 $ ,-uf -J* % "43 -'S ft a % $ a :? -1 J *J Vit Vf * 1 i 9305-9313 / [Vol. 1 No. 10] 686 examination ot 82 workers and 25 practically healthy women are analyzed. Derangements of the contractile function ot the mvocardtum and the arterial tone were noted, PCG tracings often indicated the presence of latent forms of hemodynamic disorders. Signs of right heart hyperfunction became apparent earlier on the PCG than on the ECO. In most patients the absolu'e arterial pressure figures were normal, but falling of the oscillatory index, asymmetry oj the curies and symptoms of respiratory dystonia occurred frequently.--C. M. M. 9305. DZUKAEV, Z. E., and T. A. KOCHETKOVA. (Inst. Ind. M Hyg. Occup. Dis,, Acad. Med. Set, USSR, Moscow, USSR.) K voprosu y 0 tslnkovom pnevmokomoze 1 ego rentgenomorfologicheskom oto- brazhenlL (Ekspertmental'noe issledovanie). (Experimental study ot zinc-induced pneumoconiosis and its roentgenomurphological picture.] &IG TR PROF ZABoT 14(IU): 38-41. 19VU. [EneL suro.|~An expertmental Investigation was carried out an 38 rabbits which received intratracheally a zinc oxide suspension in saline (40-80 mg/kg body weight once or twice. Zinc and lead oxide proportions were 72-78 and 11-15% respectively. The rabbits were sacrified in 3.6 and 9 mo. Some ot the animals of the latter group were subjected to repeated poisoning with zinc oxide. Microscopic examination of the lungs taken from the sacrificed animals demonstrated manifestations of catarrhal bronchitis, gradual development of interstitial pneumonia resulting in pneumo sclerosis and formation of small cellular-dust loci with collagenous fibers proliferating around them. Intrantal chest roentgenograms taken in the animals failed to reveal the great majority of fibrous changes. Those ot the excised lungs reflected alterations of certain intensity in the shape of a condensed and deformed pulmonary pattern and some times of a reduced transparency of the pulmonary tissue.--C. M. M. 9306. AL'BERTON, N. I, and G. M. BALAN. (Karaganda Inst. Ind. 0 Hyg.Occup. Din, Karaganda, USSR.) O stlmuliruyushehem vllyanti X prodigiozana pri lechenii khronicheskikh bronkhitov i pnevmonii u 2 bol'nykh pnevmokoniozom ugol'shchikov. (Stimulating effect of prodlglosine in the treatment of chronic bronchites and pneumonias - in patients with coal miners* pneumoconiosis.! GIG TR PROF ZABOL 14(16): 55-38. 1970. [ Engl. sum,)-- The efficacy of prodigiosan In the treatment of miners suffering from chronic bronchitis and pneumonia was studied. This drug was given in association with antibiotics to 144 patients, with $3 others not receiving it who made up a control group. Under investigation were clinical and immunological indices along with the microflora in the expectoration. Prodigiosan was help ful in improving the clinical condition of the patients and the external respiration function. This was accompanied by a rising complement and phagocytic activity of the leucocytes, an Increase of the lysozyme and staphylococcal antitoxin titers. In controls these Improvements were less ostensible.--J. G. S. 9307. SEMAN*KIV, L V. Aktlvnost' tseruloplazmina prl pnevmoO koniozakh 1 pylevykh bronkhitakh. (Ceruloplasmin activity in pneumoX conlosis and dust-induced bronchitis. I GIG TR PROF ZAiKDl T? 2 (10): 4-55. 1970.--The ceruloplasmin activity was studied in the blood of patients with pneumoconiosis, dust -induced bonchitis and in workers where the percentage of free SlOj in the polymineral dust varied from 0.2-23 with the high level of the dust content. An increase in the ceruloplasmin activity as a non-specific parameter appears in the early stages of pulmonary diseases of dust etiology and in workers with prolonged (10-15 yr) assignments in a dusty atmosphere. In patients with chronic bronchitis and pneumoconios there was an Increase in blood plasma activity. With progression of the disease these changes became persistent. Testing for Increased ceruloplasmin activity is recommendtd as preventive measure. --N. L. G. 3308. DZIZINSKII, A. A., and U Y. ZISSER. (Med. Inst.. NovoM Sibirsk, USSR.) Pronitsaemost1 krovenosnykh kapillyarov, geparln 1 O flbrinoliz v patogeneze 1 klinike sllikoza 1 olovyannogo pnevnokonioza. (Blood capillary permeability, heparin and fibrinolysis in the pathow genesis and clinical niciure of silicosis and tin-induced nneumoconio- sis.i Glfl WTPBIOF ZA66L 14(10): 52-54. 167Q.~iWnts wuh-- silicosis, Sn-induced pneumoconiosis and workers in factory conditions leading to itlicosls were studied. In patients with these disorders and thoae suspected to have silicoses there was a tendency for capil lary permeability to increaee, along with hyper-heparinemia and activation of fibrinolysis. The earliest and most frequent change occurred in the fibrinolytic activity and heparin in the blood. The in dicated enzyme shifts preliminary to capillary permeability disturbances. The syndrome of capillary-trophic insufficiency played a role In some of the pathogenic bases of pneumoconiosis. --N. L, G, 9309, NAUMENKO, 1. M,, and M. B. RAPPOPORT. (Inst. Ind. 2 HyS* Occup. Dis., Kiev, USSR.) Stravnitel'naya otsenka deistivva elektrLSvarochnogo aerozolya pri svarke elektrodami $ runiovym i margantsevym pokrytiem na tkan' legkikh, [A comparative study of 1 the effect of electric welding aerosol on the lungs during weiuing~ with rutile and manganese covered electrodes.| G1G TR PROF ZABOL 14(1U): 42-44. 1970.--Daily inhalation of electric welding aerosol was studied in white rats in chambers with a dust concentration of 150200 mg/rn^. In others electric welding dust was administered intra tracheally In Physiological solution. Of these, 1/2 were exposed to the products of rutile electrodes, the other 1/2 to Mn ones. The pathomorphological changes from different types of electrodes were similar. They were characterized by cellular-dust and fibrous foci, thickening of tissue areas alternating with emphysematous areas and sclerotic changes in the pulmonary stroma. With aerosol from the Mn electrodes, there was swelling of the vessel walls and perivascular edema, symptoms of toxic activity. Growth of cell elements in pulmonary tissue was associated with considerable changes in the content of nucleic and ascorbic acids. This was more sharply pronounced under the effect of aerosol from the Mn electrodes,--N. L. G. 9310. LAALE, HANS W. (Dep, Zool,, Univ,, Manitoba, Winnipeg, Can.) Ethanol Induced notochord and spinal cord duplications in the embryo of the zebrafish. Brachydamo reno. J EXP ZOOL 177(1); 51-64. Ulus. 1971.--Embryos of B, rerio, stage 10 (Hisaoka and Battle, '58) were exposed lor 24 hr to graded concentrations of ethanol from 1 to 3%. Developmental abnormalities included defects of the eye, i.e., approximation, confluence and fusion of the optic cups mid-ventrally, and duplications of notochord and spinal cord. Duplication of the spinal cord in the hind brain region has not been reported previously. The duplicatory effects are discussed and a mechanism of duplication by infolding roof plate material is proposed. Z 9311'. GINZBURG* E. A., M. V. SHILOVA, M. Y. KORNEEVA, E. V. LEVTONOVA, A. M. SERGEEV, V. I. ROMANOV, M. S. FILONENKO, E. S. IVANOVA, M. P. ALTYNOVA, G. A. ZUBRILINA, and U. A. SERGEEVA. (Mosc. Res. Inst. Tuberc., Min* Health RSFSR, Moscow, USSR.) Plevral'naya forma neprofessional'nDgo asbestoza. (Nonoceupatlonal asbestosis of the pleura l KLIN MED 48(12):_55-H6. Ulus. 1S76[reed. 197IJT [Engl. summ.J--The paper deals with ciinico-roentgenological data of 488 peraons with pleural calcifications, as well as the results of epidemiological analysis of the incidence of these pathological changes. The absence of any regularities of the spread of calcifi cations in the family and village, as well as the absence of relation between the Incidence of these alterations and water sources testify against an Infectious character of the disease. Apparently, the changee are a pleural form of asbestosis: the X-ray picture of pleural asbestosis is similar to that described in the pertinent literature. The age-specific peculiarities in the spread of this pathology point to the protracted epidemiological contact for the development of calcifications, this also being typical tor pleural asbestosis. The incidence of calcifications in villages sharply rises with approach to deposits at asbestos-containing caps and is greatest in the vicinity ot the latter. Grains ot asbestos were found in the street dust in populated areas where there are persons with calcifications. The literature contains no Information on the possibility of development of pleural asbestosis in the absence of enterprises engaged in the mining of this mineral.--K. M. E. X Z 9312. POLAN, C. E, and P. T. CHANDLER. (Va. Polytech. Inst, and Sate Univ., Blacksburg, Va., 24061, USA.) Metabolism of 14Ccarbonyl labeled Supraclde by lactatmg cows. J DairV sCl 54(8): 847-6 53, lllus. 1971*--The metabolism of a new organophosphorus lnsectide, Supraclde, intended for controlling alfalfa weevil and other insecta was studied in lactating cows. The labeled compound was rapidly metabolized and eliminated from the bovine. The major routes of 14c excretion were urinary and respiratory. One to two % ot the label appeared in milk, but no parent compound was present. A small percentage of milk radioactivity was identilted as a sulfoxide and sulfone metabolite. The principal radioactivity found in milk was retained in the nonextractable fraction. This was probably due to incorporation ol 14c-metabolites into synthesized natural nonfat solids of milk. F p V 9313. NEERGAARD, J., BENT NIELSEN (Kommunehosp. DLEtmiS' FAURBY, DANIEL H. CHRISTENSEN, and LE.: NrELSEN. Plasticizers in P.V.C and the occurrence of heg-tltis in a haemridlalysls unit: A preliminary communication. iSuANDj urul Nephrol ui-us. life. 19:1.-^ j- U 3 s lled ci*e* f hepatitis were observed within a period of 2 mo in a hemodialysis unit. The cases occurred in 3 patents during testing of new hemodialvsis equinment. Liven h:--sv in 2 w--' "`"''Prciiic tupautis and rhanges as m 'viral hepatitis, tvspo'-tivoly. From the tested blood tubings, nununctured 20 me" 1 a2l0rlde' dldU,vlphthalate washed out ,n an amount 11 rl , !1TM perfusate. From the tubings normally used in - the department this compound was not released on perfusion, and -' thrsVmb d`sapPeared rapidly when treatment with the use of these tubings was resumed. OLI 2536 10523-10533 [Vol. 1 NO. 11] 772 10523. MIKULINSKII, A. M., L. T. SUDONINA, N. S. LASHCHENKO, concentration increases parallel to the rising temperature inside the N. N. KOSSOVSKE and 1.1. AZOVSKAYA. (Inst. Ind. Hyg. Occup. Dis., tanks undergoing cleaning. The disease-incidence among female wor Tlflis, USSR.) Fiziologo-klinlcheskie osobennosti vibratsionnoi boleinj kers Is elevated by comparison with those doing ship repair work. u rabotayushchlkh g vysokochastotnym vrashchatel'nym lnstrumentom There Is a higher rate of cardio-vascular diseases, reproductive sys 1 putt ee profllaktlW. (Characteristics and prevention of vibration di tem disorders and respiratory disorders. Recommendations for the sease In workers handling high-frequency rotary tools. 6)G TR PROF improvement of work conditions are given.--J. F. L. ZABOL 15(13): 15-18. 1971|recd. l97ij. (Engl, summ.)---Vibration disease was diagnosed in 19.5% of 296 fitters. The disease manifested 10529. SOETHER, HALVARD. Yrkesskader under hogst. (Injuries itself aAer a service record of 5-7 yr. Its characteristic features In forest work.1 TIDSSKR SKOGBRUK 79(1): 35-41. Illus. TTfL vere a mildly pronounced vegetative-sensory polyneuritis or angio- [EngL summ. j--In forestry there are more registered accidents/1000 dystonic Syndrome and degenerative-trophic changes in the bones and man-years worked than in any other Norwegian trade or industry. vertebral column with no concomitant lesion of the internal organs. A total of 101 cutters were studied in fistlandet and Trdndelag. Every Most patients were able to continue their occupational activities. 7th cutter suffered from injuries during the season 1969/70, This Neurotrophic disturbances of the hands prevailed, with a marked pain was 143 injuries/1000 man-years worked. Many failed to use safetv component and reduced muscle performance. Workers handling abra equipment, especially the older cutters. Only about 1/2 had first aid sive discs for processing developed vibration pathology after a lapse equipment with them.--J. F. L. Of 9-12 and 16-19 yr. In this group the angiodystonlc syndrome was of moderate intensity with a mildly expressed pain component. A new 10530. MCBRIDE, M. E. (Baylor ColL Med., Houston, Tex., 77025, pneumatic tool provided with vibration damping arrangement was de USA.), L. F. MONTES, W. J. FAHLBERG and J. M. KNOX. Microbial B vised and a rational work schedule recommended.--J. F. L, flora of nurses* hands; 1, Quantitative differences In bacterial popu- q latlon ~between nurses and` other ooccupa~tiona=l groups. INT" J DERMA- 10524. SOLOV'EVA, V. P. and A. S YURCHENKO. (Inst. Ind. Hyg. ftiL 11(1): 49-53. 1972. | Fr. and Span, summ)]--The microbial Occup, DIS., Acad. Med. Sci. USSR, Moscow, USSR.) Flaiologlcheslotya flora of the palms and Interdigital areas of the hands in nurses was kharalrtcristtka napryazhennosti truda pri rabote za pul'taml uprav- determined quantitatively and compared with a control group. The leniya. [Physiological characterization of the intensity of work at con trol desks. I GIGTR PROF ZABOL 15(4): 13-ll 1571. lEngL sumrn.1 numbers of bacteria/cm* on the palm ranged between 0-log 3.61 In nurses and log 1.54-5.03 In controls with means of log 1.94 and 2.79 --Results of a comparative Investigation into physiological shifts (EEG, and medians of 2.00 and 2,69 tor-each respective group. The bacterial ECO, rate of information processing, speed of oculo-motor reaction, counts from the webs ranged from 6 to log 3.47/cm9 in nurses and etc.) occurring under the effect of work at control desks when on duty log 0,48-3.43 in controls. Mean values were 0.10/cm- for the nurses and In a laboratory are reported. A relationship between changes of and 1.69 for the controls. Medians were log 0,94 and 1,67 lor each physiological functions and the Intensity of work, determined by the group respectively,--J. F. L. amount of the incoming information, the sense of responsibility and the emotional stress, was discovered. The data was used in elaborating 10531. OLDER, HARRY J. and BERNARD J. CAMERON. (Bto- 'criteria of the intensity of work at control desks.--J. F. L. TechnoL, Inc., 3027 Rosemary Lane, Falls Church, Va., 22042, USA.) 1 Human factors aspects of air traffic controL NASA (NATL AERO- l`(3525. FILATOVA, V. S. and V. A. ANTONYUZHENKO. (Inst. Ind. NAUT SPA^E ADM) CONTRACT REP CR(1957); 1-163. Illus. 1972. Hyg. Occup. Die,, Gorki, USSR.) Glglenicheskle uslovlya truda 1 pro- y fessional'naya zabolevaemost* rabochikh proizvodstva suspenzionnogo polivlnilldilorida v dinamike za ryad let. (Hygienic conditions of work --This report presents an overview of human factors problems asso ciated with the operation of present and future air traffic control sys tems. A description is included of those activities and tasks per and occupational disease incidence among workers engaged in the pro formed by air traffic controllers at each operational position within duction of suspension polyvinyl chloride.! GIG TR PROF ZABOL the present system. Judgmental data obtained from controllers con 15(4); 32-34.1971. [Engl. summ.(--Disease incidence in workers in cerning psychological dimensions related to these tasks and activities contact with polyvinyl chloride was studied for 1$ yr (1953--196S). are also presented. Tbs analysis Includes consideration of psycho- Introduction of improved machinery and ventilation in the premises physiological dimensions of human performance. The role of the human Contributed to the Improvement of hygienic conditions. The clinical picture of the poisoning changed accordingly, with a longer period of controller In present air traffic control systems and his predicted role in future systems la described, particularly as that role changes development. However, the existence of technological operations which as the result of the system's evolution towards a more automated con do not yet meet hygienic requirements, led to a subsequent rise in the figuration. Special attention Is directed towards problems of staffing, air concentration of vinyl chloride and to the appearance of new cases training, and system operation. A series of 10 specific research and of chronic occupational poisoning. A considerable variability in the development projects are recommended and suggested work plans for i clinical manifestations of chronic vinyl chloride poisoning as a func their Implementation are included.--J. F, L. tion of the environmental air contaminations was established. A series of measures designed to improve the air of work premisee are sug gested.--J. F. L. 10532. MORGAN, K. Z. and E. G. STRUXNESS. (Health Phys. Div., 10526. LOMAREV, P. L, S. N. POPOV, A. M. TYURIN and Y. M. SHAPRATTS. (P. F. Lesgaft Inst. Phys. Cult., Leningrad, U55R.) 0 vliyanll zanyatli sportom na chastotu 1 dllteTnost' nekotorvkh zabolevanlL (Effect of sporting activities on the Incidence and duration of some diseases, I s6V MBb 34(2): TM-1M.~B)T1. lEnaC summ. i-- The frequency and duration of acute affections were studied in sports men and In non-athletic persons. Severe colds were much less frequent In the former while diseases of the locomotor apparatus were more frequent. This Is attributed to the stress sportsmen are subjected to during training and performance. In sportsmen diseases last for a Shorter time. Sporting activities do not change In the Incidence of "acute- morbidity.--J. F. L. Oak Ridge Nat. Lab., Oak Ridge, Tenn., 37830, USA.) Criteria for the control of radioactive effluents. INT J ENVIRON STUD 2(2): 111119. Illus. 1971.--'The risks to the population from the U.S. nuclear energy industry are considered to be very small in comparison with other environmental risks. However, they are not zero and, on the as sumption that radiation damage Increases linearly with the accumulated dose, they can be expected on a statistical basis to result In a few deaths in the exposed population. Thus, the routine operation of these nuclear power plants may cause about 18 deaths/yr and the serious accidents, which may occur at a frequency of once every 50 yr, may add another 8 deaths/yr on the average. This Is considered to be a small price to pay relative to the real but less-well-defined environmental risks from atmospheric pollution caused by fossil fuel power plants. Assuming 10527. RETNEV, V. M. (S. M. Kirov Inst. Postgrad. Med., Lenin grad, USSR.) Nekotorye voprosy glgleny truda v svyazi 1 korapleksnol avtomatizatsieL (Industrial hygiene In relation to complex automation.] GIG TR PROF ZABOt 15(4): 9-12. 1971. (Engl summ.]--Complex automation generally leads to Improved working conditions. Hygienic the proper selection Of a reactor site and all practicable precautions In the design and operation of a nuclear power reactor, adequate radia tion protection for nearby populations can be assured by concentrating health physics attention on the critical radionuclides, critical pathways and critical segments of the population. advantages include: favorable working conditions in most premises ac comodating control desks, reduction of the number of operators engaged at work places presenting occupational hazards, and a decrease ol phy 10533. GARNIER, ARLETTE. (Comm. Energ. Atom., Fonteny-Aux- sical efforts. Hygienic shortcomings attending complex automation are Roses, Fr.) Evaluation des doses d'irradiation interne defivrees aux of a temporary and avoidable nature. They comprise a considerable indivldus du public par suite de la pollution des aliments par le 96Sr nervous and psychic stress owing to a large volume ol Information and et le 137CS, en vue de la determination des niveaux de rejet des ra adverse working conditions at the control desks. In individual instances dionuclides dans le milieu ambiant. (Evaluation of the internal nega these factors tend to increase the sick-raie among the operators. tion doses undergone by the general public as a result J- /r--, unu --J. F. L, 137 pollution ol lood ana determination ot the levels oi radipr.'jrlN.e discharge into the environment. | HEALTH Phys jZ 261-277, 10528. KRYZHANOVSKE, N. V, Glglenicheskle uslovlya prl zachistke Illus. 1972. [Engl. summ.[--This study Is aimed at the investigation neftei&llvnyfch sudov 1 ikh vliyanie na zdorov*e rabochikh, (Hygienic of models for the determination of levels of discharge of radioactive conditions.In cleaning oil tankers and their effect on the workers' substances Into the environment. For this purpose, it is proposed to health.1 ' GIG TR PROF ZABOL 16(3): 14-17. 1571. (Engl, summ.1 estimate the average internal radiation dose resulting from contamina --When cleaning oil tankers the hydrocarbons In the air exceed the tion of the food-chain by 9Sr and 137Cs, taking into account the condi maximum permissible concentration In 54.3% of cases handling crude tions and transfer mechanisms of the environment, the various finks oil and in 64.1% of cases dealing with diesel olL The hydrocarbon in the food-chain, and the characteristics of the population groups con- n-toduced enhancement of atided ribonucleic aclda (Jen Virol 18:337-45. Mar 75 'ilcitr/ EFFECT, VIRAL/ tclty/ DNA, toxicity/ y/ fibroblasts/ hela jterferon, CELLS/ MICE/ POLY UCLEOTIDES. toxicity/ 11J/ RNA, blocyntheaila/ , VIRAL, toxicity/ RNA INS, toxicity/ thofenlclty/ VENOMS, ICATION CTER1AL oflcal characterization of idlpyruvate carboxyklnaae. Blechem 3:99-112, 1875 :/ ANIMAL BOXY-LYASES, laolatlon IFUGATION/ CHROMATOGRAPHY. /DOTOXINS, ZYM* INDUCTION, FUSION TESTS/ GEL <YAPATITE/ ItESIS/ ISOELECTRIC ozymology/ MALE/ 1SPHOENOLPYRUVATE yntbeala/ VTE CARBOXYKINASE, ' POISONING, BAR1DES, PRECIPITATION/ SALMONELLA ^FILTRATION ly In bacterial vacctnea rroblol 55:403-7, Mar 73 PERIMENTS/ , toxicity/ BODY pharmacodynamlce/ icodynamlca/ DRUG CHIA COLI/ acodynamlce/ HEAT/ ITONEAL/ LETHAL CCHARIDES. toxicity/ NE, IOTREXATE, ' mice, inbred ' bartnacodynamlca/ toxicity/ ICTERIAL, toxicity/ INOSA/ A/ SPECIES '-PARATYPHOID ICINES. medication bezoar In owoaead CM Jr, et al. 17 May 73 * <UM HYDROXIDE UMINUM ut.c u,e , !?Ii!ULE' pathology/ FEMALE/ *FOrcVm ,B0DYGGRRaASNUjVLOoMSA*6, 1^etiology/ GRRAENAUCLnOoMi?A/ pathology/ HUMAN/ MIDDLE AGE/ ' POLYTETRAFLUOROETHYLENE, advene fta/ PROSTHESIS, advene effect./ STARCH fd've^eHe'cU*'" e""t*/ nS'si;-zraaru-. a. ABDOMINAL, tur|ry/ "BLOOD TOSTHM?S>S]?ESB/iLOOD VESSEL |TM?V1 H/ EESVISALaUdAvTerIOeNeSffTeUctD*/IECSO/MMPpAaRrAaTtiIvVpE ARTraSv'^TM?1^' TMan/ ILIAC raSMSS, ^yethylene oc^i^Si,'ii!ri't,0ROETHYLENE/ POLYTETRAFLUOROETHYLENE. advene Mecta/ POSTOPERATIVE COMPLICATIONS POISON1NQ 5743. Pulmonary edema after Inhalation of fume, r.TM r>^lTMn-0roeth3'l*ne (PTFE). Evtuu. 1 * M,d >5 5-01. Jul 73 HEAT/ NOTCWATIONAL loiSEASES^chemlcallr i^p^CUPATI0NAL DISEAS*^ ^j'udONA^Lvnv2YI'HyLENK' Pclnnnlng/ SZV radTo'frapby 'WlaCW5' ------'mw* nunea, rai POLYVINYLPYRROLIDONE adverse effects 3744. Ruction to povidone-iodine eurglcal acrub DjwAi^y^oOTSS^SoioS1;**^ HYSTERECTOMY/ LYMPH NODE EXn<iin/ ?PPER*'r>VE CARE/ SKIN/ STERILIZATION rf,eCt*/ POLYVINYLS ADVERSE EFFECTS S745. Plaatlclzera to bumaa Haauea. Rubto RJ, et al Engl J Med 288:915-6, 26 Anr 7\ ^ss^jssssssr O f toxicity K) 3748. I^P-tlenal polyvlnyllc .empathy] Dugoi. P. et M U1 BeAuDfUloLeTF/r .DBOerNmEatoDlISBEnAUSkllu! 7c9h 1e9n7*z6.hliit* f<*F"..,> 00 Induced/ CASE REPO'RHTA/NEDDEDMEAR,MCAhTemOiScaEll^y chemically Induced/ HUMAN/ MAI Hr OCCUPATIONAL DISEASE/ S^RHT"Yiv"ARY ^LERODERMA, SYST^Kiz,^11^ 5m- "srbnisrsrc? Tr*3 Ml n , A * 4L 3 f . {2* /?73 r! 2748. Dilemma* in potassium therapy. Burchell UB, Circulation 47:1144-5, Jun 72 ACID-BASE EQUILIBRIUM/ ARRHYTHMIA, drug therapy/ * ARRHYTHMIA, etiology/ HEART ARREST, chemically induced/ HUMAN/ HYPOKALEMIA, drug therapy/ POTASSIUM, administration A dosage/ POTASSIUM, adverse effects/ POTASSIUM, metabolism/ POTASSIUM DEFICIENCY, complications/ 'POTASSIUM DEFICIENCY, drug therapy 2749, Chromium-amino acid conjugates aa ellcltors In chromlum-senaltlzed guinea plga* Slununes E, et al. 2 Invest Dermatol 60:193-6, Apr 73 AMINO ACIDS/ ANIMAL EXPERIMENTS/ ANTIGENS/ CHEMISTRY/ 'CHROMIUM, adverse effects/ 'DERMATITIS, CONTACT, etiology/ DRUG HYPERSENSITIVITY/ GUINEA PIGS/ INJECTIONS. SUBCUTANEOUS/ METHODS/ POTASSIUM, adverse effects/ SKIN, drug effects/ SKIN TESTS 9750. t Effect of salt dust on tbe mucous membrane of ihe upper respiratory tract In rabbits] Frey HH. ct al. Moaatsacbr OhrenbailM LaryngorhJnol 107:6-16, Jan 73 (Eng. Abitr.) (Oer) ANIMAL EXPERIMENTS/ CALCIUM, adverae effects/ 'DUST/ ENGLISH ABSTRACT/ ENVIRONMENTAL EXPOSURE/ INDUSTRIAL MEDICINE/ MAGNESIUM, adverse effects/ MUCOUS MEMBRANE, drug effects/ NASAL MUCOSA/ POTASSIUM, adverse effects/ RABBITS/ 'RESPIRATORY SYSTEM/ 'RESPIRATORY TRACT DISEASES, etiology/ SODIUM, adverse effects 3751. Drag therapy for cardiac arrhythmias. Chung EK. Foatgrad Med 53:107-14, Apr 73 ARRHYTHMIA, drug therapy/ ATROPINE, adverae effects/ ATROPINE, therapeutic use/ BRBTYLIUM COMPOUNDS, adverse effects/ BRETYLIUM COMPOUNDS, therapeutic use/ DIGITALIS GLYCOSIDES, adverae effects/ DIGITALIS GLYCOSIDES, therapeutic uae/ DIPHENYLHYDANTOIN, adverse effects/ DIPHBNYLHYDANTOIN, therapeutic use/ EPINEPHRINE, adverse effects/ EPINEPHRINE, therapeutic uae/ HUMAN/ ISOPROTERENOL, adverae effecte/ ISOPROTERENOL, therapeutic uae/ LiDOCAINE, adverae effects/ LIDOCAINE, therapeutic uae/ 'MYOCARDIAL DEPRESSANTS, therapeutic uae/ POTASSIUM, adverae effects/ POTASSIUM, therapeutic uae/ PROCAINE AMIDE, adverse effecta/ PROCAINE AMIDE, therapeutic uae/ PROPRANOLOL, adverse effects/ PROPRANOLOL, therapeutic use/ QU1NIDINE, adverse effects/ QU1NIDINE, therapeutic uae POISONING 3752. [Caustic burns of tbe esophagus In African children! Durenne JM, et al. Ado Soc Self Med Trap 52:499-506,1972 (Eog. Abstr.) (Fre* ACCIDENTS, HOME, prevention & control/ 'BURNS, CHEMICAL/ BURNS, CHEMICAL, complications/ BURNS, CHEMICAL, diagnosis/ CHILD/ CHILD, PRESCHOOL/ DILATATION/ ENGLISH ABSTRACT/ ESOPHAGEAL STENOSIS, etiology/ ESOPHAGEAL STENOSIS, therapy/ 'ESOPHAGUS, injurlea/ FEMALE/ HUMAN/ IVORY COAST/ POTASSIUM, poisoning 3753. E Acute fatal bichromate poLaonlng] Schlatter C, et al. Beltr Gerlchtl Med 30:382-8, 1973 (Eog. Ahatr.) (Oer> ACUTE DISEASE/ CHROMATES, meUbollam/ CHROMATES, poisoning/ ENGLISH ABSTRACT/ FEMALE/ HEMOGLOBIN/ secret urine , POTA \ RATS 3755. Animal aenslUz'pemonf dlchroo Dermal ANl* toalci HYPI Indue ABS1 POT TIM> POTASS1UV ADVERSE 3756. Gastric 1 Jacob* ADL FEM then sdml CHL' CHL CHL ULC ULC ENT 3757. Potasalu parent Br K> ADL HY PAR PAR PLA adm CHI 3756. Mortal11 J Occ ACC to or1 HEA IND com UJ NE( NEl etlo mor PNh CHI CHI pyi POTASSlUf POISONlh 3759. Potaaat et al AD che *P< 3760. | Case Farm V> Ul AN EN PO *s/ pol >0 nduced/ FEMALE/ INTESTINAL, dnu ESTINAL Ur Induced/ `KIDNEY illcation*/ KIDNEY (berapy/ MALE/ RHAGE, IRENES, adverse i. therapeutic uae/ therapy/ SULFONIC SULFONIC ACIDS* LENG a of the oval window. I Otol B7:M5-*B. Apr 71 1IDDL8/ EAR, . 4 ALE/ *FOREIGN F REACTION/ G HANULOliA,*, >DLE AGE/ * IYLENE, adverse Iverae effect*/ erae effects/ rurfery. Boyd DP* et al. 151-4* Apr 73 urgery/ `BLOOD 1LOOD VESSEL recta/ COMPARATIVE STUDIES/ HUMAN/ ZLZAC "ETHYLENE HYLENE/ IYLENE, adverse E COMPLICATIONS Uatlon of fumes from rTE>. Evans EA. Jo) 73 'SURE/ HEAT/ E AGE/ SES, chemically L DISEASES, IYLENE, poisoning/ chemically Induced/ adiography urglcal scrub associated tans. Llorens AS. 1:034-5, 1$ Nov 72 'ASMS, surgery/ 1\ etloLogy/ . preveolion A , .*#31 * ,u DRUGS AND CHEMICALS POTASSIUM j Laryngol Otol 87:203-79, Mar 73 ADOLESCENCE/ ADULT/ AGED/ CELLS, CULTURED/ CHILD/ CHILD, PRESCHOOL/ FEMALE/ HUMAN/ HUMIDITY/ INFANT/ `INTUBATION, INTRATRACHEAL/ INTUBATION, INTRATRACHEAL, adverse effects/ LARYNGITIS, therapy/ LARYNX, surgery/ LUBRICATION/ MALE/ METHODS/ MIDDLE AGE/ POLYVINYLS/ POLYVINYLS, toxicity/ POS'iflPERATI 9 E' CARE/ SILICONES/ SODIUM CHLORIDE POTASSIUM ADVERSE EFFECTS 3748. Dilemmas In poUulum therapy. Burchell HB. Circulation 47:1144-5, Jun 71 ACID-BASE EQUILIBRIUM/ ARRHYTHMIA, drug therapy/ -ARRHYTHMIA, etiology/ HEART ARREST, chemically Induced/ HUMAN/ HYPOKALEMIA, drug therapy/ POTASSIUM, admlulatratlon & doaage/ POTASSIUM, adveree efrecta/ POTASSIUM, meUbollnn/ POTASSIUM DEFICIENCY, complications/ -POTASSIUM DEFICIENCY, drug therapy 1749. Chromium-amino acid conjugate, a, ellcltors In chromlum-aenaltlred guinea plgi. Sbmunes E, et aJ. J Inveat Dermatol 40:195-4, Apr 71 AMINO ACIDS/ ANIMAL EXPERIMENTS/ ANTIGENS/ CHEMISTRY/ -CHROMIUM, adeem effecta/ -DERMATITIS, CONTACT, etiology/ DRUG HYPERSENSITIVITY/ GUINEA PIGS/ INJECTIONS, SUBCUTANEOUS/ METHODS/ POTASSIUM, advene effecta/ SKIN, drug effecta/ SKIN TESTS 5759. [Effect of aalt duet on the mucoua membrane of the upper respiratory tract In rabbital Frey HH, et el. Monatiachr Ohrenhellhd Laryagorblnol 107:4-14. Ian 75 (Eng. Abatr.) (Ger) ANIMAL EXPERIMENTS/ CALCIUM, advern eftecta/ -DUST/ ENGLISH ABSTRACT/ ENVIRONMENTAL EXPOSURE/ INDUSTRIAL MEDICINE/ MAGNESIUM, adveree effecta/ MUCOUS MEMBRANE, drug ettecta/ NASAL MUCOSA/ POTASSIUM, adverae effecl*/ RABBITS/ -RESPIRATORY SYSTEM/ -RESPIRATORY TRACT DISEASES, etiology/ SODIUM, adverae elfecta 3751. Drug therapy for cardiac arrhythmlaa. Chung EK. Foat,rad Med 55:197-14, Apr 75 ARRHYTHMIA, drug therapy/ ATROPINE, adverse elfecta/ ATROPINE, therapeutic use' BRETYL1UM COMPOUNDS, adverae effects/ BRETYL1UM COMPOUNDS, therapeutic uae/ DIGITALIS GLYCOSIDES, adveree elfecta/ DIGITALIS GLYCOSIDES, therapeutic use/ DIPHENYLHYDANTOIN, adverae effects/ DIPHENYLHYDANTOIN, therapeutic uae/ EPINEPHRINE, adverae effects/ ....... * ................ lltTM 4N ' HUMAN/ MIDDLE AGE/ POISONING, pathology/ POTASSIUM, poisoning/ SUICIDE TOXICITY 3754. lActlvatlon or renal potassium elimination and reduction of potassium toxicity through repeated ceding with KCI solution In rats of various ages) Puichmann R, et al. Acta Biol Med Ger29:B77-87,1971 (Eng. Abatr.) (Get) AGE FACTORS/ ANIMAL EXPERIMENTS/ ENGLISH ABSTRACT/ FEMALE/ KIDNEY TUBULES, drug elfecta/ -KIDNEY TUBULES, netabollam/ KIDNEY TUBULES, secretion/ MALE/ -POTASSIUM, metabolism/ POTASSIUM, pharmacodynamics/ POTASSIUM, secretion/ POTASSIUM, toxicity/ POTASSIUM, urine/ POTASSIUH CHLORIDE, metabolism/ POTASSIUM CHLORIDE, pharmacodynamic*/ RATS 3755. (Animal experiment models lor demonstration of sensitization potency o( drug combinations. 1. Demonstration of sensitization potency of potassium dlchromate under various conditions) Loecbel 1, et al. Dsrmatol Monataachr 159:551-4, Mar 73 (Eng. Abatr.) (Gar) ANIMAL EXPERIMENTS/ -CHROMATES, toxicity/ DISEASE MODELS. ANIMAL/ -DRUG HYPERSENSITIVITY/ -ECZEMA, chemically Induced/ ECZEMA, pathology/ ENGLISH ABSTRACT/ GUINEA PIGS/ MALE/ POTASSIUM, toxicity/ SKIN, pathology/ TIME FACTORS POTASSIUM CHLORIDE ADVERSE EFFECTS 3754. Gastric ulcers due to the Intake of potassium chloride. Jacobs E, et al. Am J Dig DIs 18:559-94, Apr 73 ADULT/ CORONARY DISEASE, diagnosis/ FEMALE/ HUMAN/ MALE/ OBESITY, drug therapy/ POTASSIUM CHLORIDE, administration A dosage/ -POTASSIUM CHLORIDE, adverae effect!/ POTASSIUM CHLORIDE, diagnostic use/ POTASSIUM CHLORIDE, therapeutic use/ -STOMACH ULCER, chemically Induced/ STOMACH ULCER, radiography/ TABLETS, ENTERIC-COATED 3757. Potassium overdoaage: a potential hazard of non-rlgld parenteral fluid containers. Williams RH. Dr Med J 1:714-5. 24 Mar 73 ADULT/ FEMALE/ HUMAN/ HYPERKALEMIA, etiology/ -INFUSIONS, PARENTERAL, adverse effects/ INFUSIONS, PARENTERAL, Instrumentation/ MALE/ PLASTICS/ POTASSIUM CHLORIDE, administration A doaage/ -POTASSIUM CHLORIDE, adverse effects 3758. Mortality of potash workers. Waxweller RJ, et al. J Oecup bled 15:433-9, Jun 73 ACCIDENT PREVENTION/ BRONCHITIS, -........... point-timr OGIC II.. I .UJUS,' VINYL COMPOUNDS DRUGS AND CHEMICALS VINYL COMPOUNDS POISONING D1SEASKSNS- Vet*rinarv/ 'POULTRY vaccin^. t5ZS?&t*trol/ *WRA*- SSSgSSSL SSSr"i toxicity t^RK'Ss"Tur!^K%V1c?noA`<le*;`*">> ANIMAL raPERmjENTsAcAMELs/ W (R",) INPK^ONS,NpS^- AtlcoX/|/POXVIRUS Sws\au,, VITAMIN A adverse eppects englbb^S relationship, chug/ KSSKPS* ans SSSWTM, TMS, sarcoma 1M- rarar= VIRAL VACCINES adverse eppects 4922' H!"'d* vacclnntlon In pregnnncy Drug Thtr Boll 11:13-5. l* J,h i mra'dra1^ diseases. etiology/ pRKNANrcu;/t^/Li!ni^,NE rflecU/ SHALLPo/vACCM,CXr erM VACON.7A<;fI.NATI0N- v5 ^ VIRAL VACCINES- 'p.^rsKrisr rrs*"TM- Mn*,,h V" *> a>:*54.<, I Apr' 73 (Eng, Ab.tr., o CATTLE/ 'CATTLE* ABSTR^/^^^^^^ySH Sf^vtterC"^ lTS^Tte^NT K5 veterinary/ VIRAL VACCINES COUNT. in S^LSc'"* V1BAL VACCINES, o 4SM- vaccine Tree, their progeny] *5 e? IV" MonaUb Vet Med 38:231-4, I Apr 73 (Eng. Ab.tr., ABSTnar??^ER,MENTS/ ENGLISH <0*f> ABSTRACT/ FEMALE/ *HOC chot poa v*cc"nfs & ,control/ pregnancy/ **viral vat f INFS. UviT-,,. irrrrt<i' V1T>^ 4 or _.tr.tiun corneum. Grice K, et ri wSaTHI^^^some 1,75 2s8S?KH\sFatsrsWB',jKBSSEj-5!B/ V1TAMIN rtlecf/ INWATER DOSS. 40. Acute Tunun KI. DISEASE/ ADULT/ AFRICA non-ph^S^^^^^dok. P^DLm^N./t|ofJA^E^Jr,l0U)>/ SUVR?inT?N/ *SIJNBURN, drug therapy/ disorders^C? wt,n/aVIS,ON admlnlatretlon A doMge/ VWAHm A. VITAMIN1a"?* wtkmin A, bSJd/ * etiologyN A' lller*Pe"tlc ue/ VOMITING, 4S3I. Induction by dlmetbylhydmtlne of i~.---- EW C*fr Re. 33:1WM, Il7y 73 ` " - aSTM??J^NOIIA- <*e"lUy Induced/ kn^^alexperiments/ diet/ drug HVT>RAifTLl^)cNS/ 'uvdrazines/ hydrazines, .dmlnutrallon A dome./ neoplasms "hl,C(?SA/ 'intestinal INTiStJS??- induced/ UPm?1TM !' k"^PLASMS- eompUcnUon./ HAL./' iSi0TM^?"' L,VEH- motabollra/ 5n&NwEOKPLA^SM^M^ET^ASTAS"IS't/ arcatotc'r/s/ SVITA^MIwN m*'muStj'uStuTia't-raJt^lo-nSA' VdIoTuAgMeI/N A. DETIClENC^1compIlSuo^>U,m/ *mAMIN A 4**19 Pit Pci, ,, r I TOXICITY 4636. Hypervltamlnoala A Lb rata. Var different forma, dote*, and roi LeeUprute V. et al. Arch I ANIMAL EXPERIMENTS/ RESORPTION, chemically i "CALCINOSIS, chemically i KIDNEY, drug effect*/ LP LUNG, drug effect*/ MYOeffect*/ "OSTEOPOROSIS, RATS/ VITAMIN A admin *VITAMIN A, toxicity 4096, Effect of hypervltamlnoala A corticosteroid*. Singh N. et Indian t Blocbem Blopfaya ACETATES, metabollam/ V HORMONES, bloayntheal*/ HORMONES, blood/ *ADRF drug effect*/ ADRENAL G metabollam/ ANIMAL EXP ASCORBIC ACID, meUbolh metabollam/ FEMALE/ L1V UVER GLYCOGEN, metab. STIMULATION, CHEMICAL toxicity VITAMIN B COMPLEX ADVERSE EFFECTS 4637. Behavioral effect* of drug then; Inpatient*. II. Multivitamin lupi al. 9 Am Ocrlgtr 6oe 31:34' AGED/ AGGRESSION, drug ASCORBIC ACID, adverse ACID, therapeutic uae/ *BI effect*/ CLINICAL RESEAI SYNERGISM/ FEMALE/ H( PSYCHIATRIC/ HUMAN/ V AGE/ PHEN0THIA2INE TN therapeutic use/ PLACEBO: STATUS RATING SCALES/ ORGANIC, drug therapy/ * SENILE, drug therapy/ SCI drug therapy/ VITAMIN B effecta/ *VITAMIN B COM I uae VITAMIN D ADVERSE EFFECTS 4636. Vitamin D: a reawakening. P; JAMA 224:1326-7, 11 Jun 79 AORTIC VALVE STENOSIS, Induced/ CALCIUM, mettbo METABOLISM DISORDERS, CHOLECALCIFEROL. metab ERGOCALC1FEROU meUbo) HUMAN/ HYDROXYCROLB* uic Lubollsm/ nVPE^ALCU induced/ i;,`?ANT/ KIDNEY DRUGS AND CHEMICALS POLYVINYLS POLYMERS ADVERSE EFFECTS 3381. [Dermatoses caused by melamine] Soubrler R, et al. Arch Mai Frol 33:203-4, Apr-May 72 (Fre) ENVIRONMENTAL EXPOSURE/ FEMALE/ HUMAN/ -OCCUPATIONAL DERMATITIS/ -POLYMERS, adveree ellecta/ SKIN TESTS 3332. The effect of a aynthetlc anlonle polymer (pyran! os the development of foot-and-mouth disease Is guinea-pigs. cattle and pigs. Sellers RF, et aL Rea Vet Sel 13:333-41, Jul 72 ANIMAL EXPERIMENTS/ BODY WEIGHT, drut effeeu/ CATTLE/ CATTLE DISEASES, prevention U control/ -FOOT-AND-MOUTH DISEASE, prevention it control/ GUINEA PIGS/ INJECTIONS. INTRAPERITONEAL/ INTERFERON, analysis/ INTERFERON INDUCERS, therapeutic use/ -MALEATES, therapeutic uie/. PERITONEAL DISEASES, chemically Induced/ POLYMERS, adverse effeeu/ 'POLYVINYLS, therapeutic use/ SWINE/ SWINE DISEASES, prevention A control 3333. [Health bases for standards for school bulldlnfs and equipment] Korencveksta EL Vettn AJtad Med Nank SSCR 37:23-33, 1371 (Real ADOLESCENCE/ -ARCHITECTURE/ CHILD/ CONSTRUCTION MATERIALS, adverse effects/ ENVIRONMENTAL EXPOSURE/ ENVIRONMENTAL HEALTH/ HEATING/ HUMAN/ LIGHTING/ POLYMERS, adverse effeeu/ -SCHOOL HEALTH/ USSR 3334. [Relapse prevention of the allerclc shoe eeaema) Kalkoff KW. Z Han Gesehlechtskr 47:383-4. 3 Jul 7* (Oerl DERMATITIS. CONTACT, etlolofy/ , 'DERMATITIS. CONTACT, prevention A / control/ FEMALE/ FOOT DERMATOSES, chemically Induced/ 'FOOT DERMATOSES, prevention A control/ HISTOCOMPATIBILITY TESTING/ HUMAN/ METHODS/ POLYMERS, adverse eflecU/ PROTECTIVE DEVICES/ RECURRENCE/ 'SHOES, adverse effeeu POLYMYXIN ADVERSE EFFECTS 3333, Monlllal sepals in the aurclcal patient, Richards CE. et at Sure CUn North Am 32:1333-403, Dec 72 ADOLESCENCE/ ADULT/ AGED/ AMP1C1LLIN, adverse effecU/ BODY TEMPERATURE/ 'BURNS, complications/ BURNS, microbiology/ CANDIDA ALBICANS, isolation A purification/ CARBENICILUN. adverse effeeu/ CATHETERIZATION, advert# effeeu/ CHILD/ CHILD. PRESCHOOL/ CHLORAMPHENICOL, adverse effeeu/ DRUG RESISTANCE, MICROBIAL/ ERYTHROMYCIN, adverse effecU/ FEMALE/ GENTAMICIN, adverse effecU/ HUMAN/ INFANT/ KANAMYCIN, adverse effecU/ MALE/ MIDDLE AGE/ 'MONILIASIS, etiology/ MONILIASIS, microbiology/ MONILIASIS, urine/ NASOPHARYNX, microbiology/ PENICILLIN, adverse effecU/ POLYMYXIN. \ adverse effecU/ 'SEPTICEMIA, etiology/ SURGERY. OPERATIVE/ TETRACYCLINE, adverse effecU/ URINARY CATHETERIZATION, advene effecU/ WOUND INFECTION, microbiology POLYSACCHARIDES TOXICITY 3338, Antitumor activity of the yeast manaan preparation In relation to the effect of chemical modlitcation. Oka S, et al. Gann 33:383-8, Jun 72 ACYLATION/ ADMINISTRATION, ORAL/ ANIMAL EXPERIMENTS/ ANTINEOPLAST1C AGENTS, admlnUtratlon A doaage/ 'ANTINEOPLASTIC AGENTS, therapeutic use/ ANTINEOPLASTIC AGENTS, toxicity/ 'CANDIDA/ COMPARATIVE STUDY/ FEMALE/ HYDROLYSIS/ INJECTIONS. INTRAPERITONEAL/ INJECTIONS, INTRAVENOUS/ INJECTIONS. SUBCUTANEOUS/ MALE/ METHYLATION/ MICE/ MOLECULAR WEIGHT/ NEOPLASM transplantation/ polysaccharides, administration A dosage/ 'POLYSACCHARIDES, therapeutic use/ POLYSACCHARIDES, toxicity/ 'SARCOMA 180, CROCKER, drug therapy POLYTHIAZIDE ADVERSE EFFECTS 3337. Propranolol aod polythlazlde In treatmaot of hypertenalon. O'Brien ET, et al. , Br Heart J 34:1042-4, Oct 72 ADULT/ BLOOD PRESSURE, drug effecU/ BRONCHIAL SPASM, chemically Induced/ 'DRUG SYNERGISM/ DRUG WITHDRAWAL SYMPTOMS/ FEMALE/ HALLUCINATIONS, chemically Induced/ HUMAN/ HYPERTENSION, drug therapy/ MALE/ MIDDLE AGE/ NEGROES/ POLYTHIAZIDE, adverae effect#/ `POLYTHIAZIDE, therapeutic use/ PROPRANOLOL, adverae eflecu/ PROPRANOLOL, therapeutic uae/ PULSE, drug effecU/ RACIAL STOCKS/ SLEEP DISORDERS, chemically Induced/ VERTIGO, chemically Induced POLYVINYLPYRROLIDONE ADVERSE EFFECTS 333S. [Hepatomegallc form of a theaaurlxmaela earned by polyvinylpyrrolidone after prolonged treatment with deleyed-aetlon poaterlor pltulUry preparation! Foaanti p, et al. Eev Ft Endocrinol Clin 13:37-32, Jao-Feh 72 (Eng- Abetr,) <rrl BIOPSY/ DELAYED-ACTION PREPARATIONS/ DIABETES INSIPIDUS, drug therapy/ ENGLISH ABSTRACT/ 'HEPATOMEGALY, chemically induced/ HUMAN/ INJECTIONS, INTRAMUSCULAR/ 'LIVER, metabolism/ LONG TERM CARE/ MALE/ 'METABOLIC DISEASES, chemically induced/ MIDDLE AGE/ PITUITARY HORMONES, POSTERIOR, administration h dotage/ POLYVINYLPYRROLIDONE, admlnUtratlon A doeago/ 'POLYVINYLPYRROLIDONE, advorao effecU/ POLYVINYLPYRROLIDONE. meUbolUu/ 'VEHICLES, advene effecU/ VEHICLES, metabolism POLYVINYLS A9TUIE KITZCTt S3M. [ScUrodrma Ilk* tkia ctunfe*. Raynaud** syndrom* tad *oroo*t*oly*M la workar* la tb* polyvinyl cblorld* producing Industry] JUhe $, *t *1, DUck Mod Woh*ftschr *7:19*2.3, 3 Dec 71 (Gtr) ARM# blood supply/ ARTERIES# radiography/ BONE RESORPTION, chemically induced/ ENVIRONMENTAL EXPOSURE/ UNGERS/ HUMAN/ MALE/ 'OCCUPATIONAL DISEASES# chemically induced/ POLYVINYLS# adverse effects/ 'RAYNAUD'S DISEASE# chemically induced/ 'SCLERODERMA# CIRCUMSCRIBED, chemically induced .2 7. 3338, Occupational aapecu of Raynaud's disease: a critical (tutorial gurvey. Christopher* AJ. Med t Aast 1:730-3, 23 Sep T1 BONE RESORPTION, chemically Induced/ COLD/ CONSTRICTION/ FINGERS, blood supply/ GERMANY/ GREAT BRITAIN/ HISTORICAL ARTICLE/ HISTORY or MEDICINE. 18TH CENT./ HISTORY OF MEDICINE. 20TH CENT./ OCCUPATIONAL DISEASES, etiology/ OCCUPATIONAL DISEASES, bUtory/ POLYVINYLS, adverse effecU/ RAYNAUD'S DISEASE, etiology/ RAYNAUD'S DISEASE, history/ ROME/ UNITED STATES/ VIBRATION M. 3131. The invisible pollution. Rail Dp. N Engl 3 Med 227:1143-7, 30 Nov 72 BLOOD PRESERVATION, InstrumenUtton/ BLOOD TRANSFUSION/ CHLORINE/ DISPOSABLE EQUIPMENT/ ENVIRONMENTAL POLLUTION/ HUMAN/ PHTHAL1C ACID, adveree effecU/ PHTHALIC ACID, blood/ PHTHAUC ACID, meUbolUm/ 'PLASTICS, adverae effecU/ 'POLYVINYLS, adverae effecU/ POLYVINYLS, meUboUam 3301. [Histological and hutochamlca] changes observed Ut the liver in experimental pneumoconloaU Induced by polyvinyl chloride! Cylwtk B. Root Akad Med Bialymitoku 17:33-111, 1972 (Eng. Abstr.) (Foil ANIMAL EXPERIMENTS/ CHLORIDES, adveree effeeu/ ENGLISH ABSTRACT/ FEMALE/ LIVER, drug effecU/ 'LIVER, ' 7 pathology/ MALE/ PNEUMOCONIOSIS, . OLI 2541 A-273 * A / DRUGS AND CHEMICALS Bo PLUTONIUM CATTLE/ `CATTLE DISEASES, diagnosis/ CATTLE DISEASES, etiology/ DIAGNOSIS, DIFFERENTIAL/ FEMALE/ HEINZ BODIES/ HEMATOCRIT/ HEMOGLOBIN, analysis/ HEMORRHAGE, complications/ HEMORRHAGE, veterinary/ MALE/ PLANT POISONING, complications/ PLANT POISONING, veterinary/ TR1CHOSTRONGYLOID1AS15. complications/ TRICHOSTRONGYLOIDIASIS, veterinary 3331. Diseases of zoo animals in Nigeria. Isoun TT, et aL J Wildl Di* 8:335-9, Oct 72 ANIMAL DISEASES, occurrence/ `ANIMALS. ZOO/ ARTIODACTYLA/ BABOONS/ BIRD DISEASES, occurrence/ CARNIVORA/ ECHINOCOCCOSIS, veterinary/ ENCEPHALITIS, veterinary/ ENCEPHALOMYELITIS, veterinary/ ESCHERICHIA COLI INFECTIONS, veterinary/ HERPESVIRUS INFECTIONS, veterinary/ MONKEY DISEASES, occurrence/ MUSCULAR DYSTROPHY, veterinary/ NIGERIA/ PERICARDITIS, veterinary/ PLANT POISONING, veterinary/ PRIMATES/ RODENT DISEASES, occurrence/ TRYPANOSOMIASIS, veterinary PLANT PROTEINS ADVEKSt EFFECTS HE. Soy prottn--another cauae of th* flat Intestinal talon. Ament ME, et *1. Gatroenterolocy 82:227-34, Feb 73 ACIDOSIS, etiology/ CYANOSIS, etiology/ DEHYDRATION, etiology/ DIARRHEA, etiology/ FEVER, etiology/ FOOD HYPERSENSITIVITY, complication!/ 'FOOD HYPERSENSITIVITY, etiology/ FOOD HYPERSENSITIVITY, pathology/ HUMAN/ /INFANT/ INFANT FOOD/ INTESTINAL DISEASES, complication*/ 'INTESTINAL DISEASES, etiology/ INTESTINAL DISEASES, pathology/ 'JEJUNUM/ JEJUNUM, pathology/ LEUKOCYTOSIS, etiology/ MALE/ 'PLANT PROTEINS, adverae effect!/ PROSPECTIVE STUDIES/ *SOY BEANS/ VOMITING, etiology PLASTER OF PARIS ADVERSE EFFECTS S3SS. i A vacuum-cleaner for relieving Irritation from plater of Peril fragment!] Allgulander S, et aL Lafcwtldnlngea *9:J588, 38 Jul 73 ($we> CASTS, SURGICAL/ 'EQUIPMENT AND SUPPLIES/ FRACTURES, therapy/ HUMAN/ METHODS/ 'PLASTER OF PARIS, adverae effect* PLASTICS ADVERSE EFFECTS 3334, Long-term effects of plastics. Toed Cosmet Tozleol 10:587-71, Aug 72 (41 ref.) ANIMAL EXPERIMENTS/ AORTIC VALVE, surgery/ BREAST, surgery/ BREAST NEOPLASMS, chemically induced/ FEMALE/ HUMAN/ HYPERSENSITIVITY/ INTRAUTERINE DEVICES, adverse effecta/ PLASTICS, advene effect*/ `PROSTHESIS, adverse effecta/ RATS/ REVIEW/ SARCOMA, chemically induced/ SILICONES/ SURGERY, PLASTIC/ TIME FACTORS 3335, (Pathogenesis of changes In the hepato-blllary ayatem la workers In the plutle industry] Reneva TG, et aL Gig Tr Prof Zabol 16:23*30. Jun 72 (Eng. Abatr.) (Ra) BILIARY TRACT DISEASES, Chemically Induced/ ENGLISH ABSTRACT/ HUMAN/ LIVER DISEASES, chemically induced/ OCCUPATIONAL DISEASES, chemically induced/ `PLASTICS, adverae effects 3333. (Preoperative assessment of risk factors in chip Implants of the nose] Hellmlch S. HNO 20:218-20, Jul 72 (Eng. Abstr.) (Gar) CARTILAGE, transplantation/ ENGLISH ABSTRACT/ HUMAN/ `NASAL SEPTUM, surgery/ `PLASTICS, adverse effects/ RHINOPLASTY/ RIBS, transplantation/ TRANSPLANTATION, adverse effect*/ TRANSPLANTATION, AUTOLOGOUS 3337. Migration of a phtbalate ester plasticizer from polyvinyl chloride blood bags into stored human blood and its localization in human tissue*. Jaeger rj, et al. N Engl J Med 287:1114-8, 30 Nov 72 ADIPOSE TISSUE, metabolism/ ANIMAL EXPERIMENTS/ `BLOOD PRESERVATION, instrumentation/ BLOOD TRANSFUSION/ CHLORINE/ CHROMATOGRAPHY. CAS/ DISPOSABLE EQUIPMENT/ DOGS/ FEMALE/ HEART SURGERY' HUMAN/ LIVER, metabolism/ LUNG, metabolism/ MALE/ PHTHALIC ACID/ PHTHALIC ACID, blood/ PHTHAL1C ACID, metabolism/ PHTHALIC ACID, urine/ `PLASTICS/ PLASTICS, adverse effects/ `POLYVINYLS/ POLYVINYLS, metabolism/ SPLEEN, metabolism/ TIME FACTORS 3338. The Invisible pollution. Rail DP, N Engl J Med 287:1146-7, 30 Nov 72 BLOOD PRESERVATION, Instrumentation/ BLOOD TRANSFUSION/ CHLORINE/ DISPOSABLE EQUIPMENT/ ENVIRONMENTAL POLLUTION' HUMAN/ PHTHALIC ACID, adverse effects/ PHTHALIC ACID, blood/ PHTHALIC ACID, metabolism/ `PLASTICS, adverse effects/ POLYVINYLS, adverse effects/ POLYVINYLS, metabolism TOXICITY 3339. The carcinogenesis of plastics used in orthopedic surgery. An assessment of the Incidence In rats and the possible relevance to man. Lavorgna JJ, et al. Clin Ortbop 88:223-7, 1972 ABDOMINAL NEOPLASMS, chemically induced/ ANIMAL EXPERIMENTS/ CARCINOGENS/ EPOXY RESINS, toxicity/ FIBROSARCOMA, chemically induced/ GLASS, toxicity/ MALE/ METHYLMETHACRYLATE, toxldty/ NEOPLASMS, EXPERIMENTAL, chemically Induced/ `ORTHOPEDICS/ PLASTICS, toxicity/ POLYETHYLENES, toxldty/ RATS/ TIME FACTORS PLATINUM ADVERSE EFFECTS 3340. Inhalation tests with chemical allergens: complex tails of platinum. Pickering CA. Free R Soc Med 65:272-4, Mar 72 `ALLERGENS, diagnostic use/ ASTHMA, chemically Induced/ HUMAN/ NOSE/ OCCUPATIONAL DISEASES, diagnosis/ PLATINUM, adverse effect*/ `PLATINUM, diagnostic use/ RESPIRATORY HYPERSENSITIVITY, chemically Induced/ RESPIRATORY HYPERSENSITIVITY, diagnosis/ SKIN TESTS/ SPIROMETRY PLUTONIUM ADVERSE EFFECTS 3341. Metabolism and biological effects of inhaled 241 Am and 239 Pu In dogs. Buldakov LA, et al. Health Phys 22:873*4, Jun 72 AEROSOLS/ `AMERICIUM/ AMERICIUM, adverse effects/ AMERICIUM, metabolism/ AMERICIUM, urine/ ANIMAL EXPERIMENTS/ DOGS/ LUNG, pathology/ LUNG, radiation effects/ NITRATES, metabolism/ OXYGEN, blood/ `PLUTONIUM/ PLUTONIUM, adverse effects/ PLUTONIUM, metabolism/ PLUTONIUM, urine/ RADIATION EFFECTS/ RESPIRATION, radiation effects/ SCLEROSIS, etiology 8342. Interpretation of human urinary excretion of plutonium for cases treated with DTPA. Jecb JJ, et aL Health Phys 22:787*92, Jun 72 AEROSOLS/ *DTPA, therapeutic use/ HUMAN/ NITRATES, adverse effects/ OXIDES, adverse effects/ PLUTONIUM, adverse effects/ PLUTONIUM, metabolism/ `PLUTONIUM, urine/ `RADIATION INJURIES, drug therspy/ RADIATION INJURIES. ,, etiology/ RADIATION INJURIES, prevention it control/ RADIATION INJURIES, urine/ TIME FACTORS 3343. Distribution sod toxicity of 230 Pu in bone. Joe WS. Health Phyi 22:583*95, Jun 72 ADMINISTRATION, ORAL/ AEROSOLS/ AGE FACTORS/ ANIMAL EXPERIMENTS/ AUTORADIOGRAPHY/ `BONE AND BONES/ BONE AND BONES, metabolism/ BONE MARROW, metabolism/ BONE MARROW, pathology/ BONE NEOPLASMS, pathology/ DOGS/ INJECTIONS, INTRAMUSCULAR/ INJECTIONS. INTRAPERITONEAL/ INJECTIONS, INTRAVENOUS/ INJECTIONS. SUBCUTANEOUS/ NEOPLASMS, A-269 OLI 2542 IGS AND CHEMICALS (Ger) VCSN, KENTIAL/ etiology/ (STIC. iBLASTIC. tlologv/ TKS10N/ rse otherapy in - eftrsinoniA, Aug 71 ECIA, TIC V : therapy/ itherapy/ rapy/ la/ ae/ IARRHEA. TODIES/ aducsd/ utic uae/ R1STINE, ictlca and : their at] Klein |71 (En*. (Oar) rapy/ LD/ 1/ ties/ re/ HUMAN/ herapy/ crapy/ TOSIS, apy/ :U/ Ucuium (Carl COMA JA V kSMS, is/ 1NE, utic : aL / atapy/ ADULT/ 'CHLORIDES, blood/ COGNITION DISORDERS, chemically induced/ GLUCOSE, therapeutic uae/ HUMAN/ 'HYPONATREMIA chemically induced/ HYPONATREMIA, therapy/ INFUSIONS, PARENTERAL/ INJECTIONS, INTRAVENOUS/ ISOTONIC SOLUTIONS/ LEUKEMIA, LYMPHOBLASTIC druf therapy/ MALE/ POTASSIUM, therapeutic uae/ SODIUM, blood/ SODIUM CHLORIDE, therapeutic uae/ VINCRISTINE, admlnlatratioo 8t dosage/ -VINCRISTINE, advarae effects/ WATER-ELECTROLYTE BALANCE $5$*- [lit experiencea with Adrlamycin, a new eytotoxie antibiotic, in combination chemotherapy gf malignant tumoraj Jungl WF, at al. SchwclxMad Wochcuachr 101:1213-11, IS Aug 71 (En*. Abatr.) (Oarl ADOLESCENCE/ ADULT/ AGED/ ANTIBIOTICS, ANTINEOPLASTIC, admlnlatratioo A dosage/ ANTIBIOTICS. ANTINEOPLASTIC, adverae effecta/ ANTIBIOTICS, ANTINEOPLASTIC, therapeutic uae/ BREAST NEOPLASMS, dru* therapy/ CARCINOMA dru* therapy/ DRUG SYNERGISM/ ENGLISH ABSTRACT/ FEMALE/ HUMAN/ LEUKEMIA MYELOBLASTIC, dru* therapy/ LUNG, radiography/ MALE/ MIDDLE AGE/- NEOPLASM METASTASIS/ OVARIAN NEOPLASMS, dru* therapy/ PREDNISONE, admlnlatratlon A doaace/ REMISSION/ SARCOMA dru* therapy/ 'TETRACYCLINE, admlnlatratlon A dosage/ VINCRISTINE, admlnlatratioo A doaa*#/ VINCRISTINE, adverae effecta SS39- Vincrlatine-Induced ayndrome of Inappropriate accretion of eotidluretlc hormone. Oldham RK, at aL South Med S *$.1010-1, Aug 73 FEMALE/ HUMAN/ 'HYPONATREMIA chemically Induced/ HYPONATREMIA dl**noaia/ MIDDLE AGE/ SARCOMA. RETICULUM CELL, dru* therapy/ TONSILLAR NEOPLASMS, dru* therapy/ VASOPRESSIN, accretion/ 'VINCRISTINE, adverae effecta SSSO. [Vinca alhalotda, a newer croup of anti-oeoplaatic dru*a] Hanaeo I, at aL Uiaakr Laeget 1M:121$-11,10 Jun 71 (71 ref.) (En*. Abatr.) man) ANIMAL EXPERIMENTS/ CHORIOCARCINOMA, dru* therapy/ DOGS/ ENGLISH ABSTRACT/ HODGKIN'S DISEASE, dru* therapy/ HUMAN/ IMMUNOSUPPRESSION/ LEUKEMIA dru* therapy/ 'NEOPLASMS, dru* therapy/ NEPHROBLASTOMA dru* therapy/ NEUROBLASTOMA dru* therapy/ REVIEW/ VINBLASTINE, admlnlatratlon A doaace/ VINBLASTINE, adverae effecta/ VINBLASTINE, therapeutic uae/ VINCRISTINE, admlnlatratlon A doaace/ VINCRISTINE, adverae effecta/ VINCRISTINE, therapeutic uae POISONING - SSS1. Syndrome of Inappropriate accretion of antidiuretic hormone produced by vlnerlttlne toxicity (with bloeaeay of ADH level). Suaklnd RM. et al. J Pedlatr 81:90-2. Jul 71 BIOLOGICAL ASSAY/ CHILD, PRESCHOOL/ EXTRACELLULAR SPACE/ FEMALE/ HUMAN/ HYPONATREMIA chemically Induced/ HYPONATREMIA dru* therapy/ KIDNEY NEOPLASMS, therapy/ MEDICATION ERRORS/ NEPHROBLASTOMA therapy/ OSMOLAR CONCENTRATION/ SODIUM CHLORID& therapeutic uae/ SPECIFIC GRAVITY/ URINE, analyaia/ VASOPRESSIN, blood/ `VASOPRESSIN, accretion/ VINCRISTINE, polaonln*/ WATER-ELECTROLYTE BALANCE, dru* effecta VINYL COMPOUNDS POISONING - $5*3. The correlation of clinical and environmental meaauremente for worker! expoted to vinyl chloride. Kramer CG, et al. Am lad Hyf assoc J 33:19-30, Jan 72 AIR POLLUTION/ 'ALKENES. poisoning/ BLOOD PRESSURE/ BLOOD PROTEINS/ CHLORIDES/ ENVIRONMENTAL EXPOSURE/ ENVIRONMENTAL HEALTH/ HEMOGLOBIN/ HUMAN/ INDUSTRIAL MEDICINE/ DRUGS At JAUNDICE, chemically Induced/ MALE/ MODELS, THEORETICAL/ 'OCCUPATIONAL DISEASES, chemically induced/ RETROSPECTIVE STUDIES/ SULFOBRQMOPHTHALEIN, blood/ TIME FACTORS/ VINYL COMPOUNDS, poisoning VIOMYCIN ADVERSE EFFECTS 5541, Druf reactions. 18. Cutaneous reactions to antituberculous druga, Levantine A. et al. Br J Dermatol 18:851-5, Jun 71 (57 ref.) AMINOSALICYLIC ACID, adverse effecta/ ANTITUBERCULAR AGENTS, adverae effecta/ CAPREOMYCIN, adverse effects/ CYCLOSERINE, adverse effects/ DERMATITIS MEDICAMENTOSA/ ETHAMBUTOL, adverae effects/ ETHIONAMIDE, adverse effects/ HUMAN/ ISONIAZJD, adverae effects/ ISON1COTINIC ACID, adveras effects/ KANAMYCIN, adverse effects/ PYRAZINAMIDE. adverae effects/ REVIEW/ RIFOMYCIN. adverae effects/ `SKIN, drug effecta/ STOMATITIS, chemically induced/ STREPTOMYCIN, adverse effects/ TH1ACETAZONE, edvene effects/ VIOMYCIN. adverse effecta 8544. Hypocalcemia, hypomagnesemia and hypokalemia during chemotherapy of pulmonary tuberculosis. Vanastn B, et al. Chest 81:498-9, May 72 ALKALOSIS, chamlcally Induced/ HUMAN/ 'HYPOCALCEMIA chemically induced/ 'HYPOKALEMIA chemically Induced/ 'MAGNESIUM, blood/ MALE/ MIDDLE AGE/ PHOSPHORUS, blood/ PYRAZINAMIDE. admlnlatratlon A dosage/ 'PYRAZINAMIDE, adverse effects/ TETANY, chemically Induced/ 'TUBERCULOSIS. PULMONARY, drug therapy/ VIOMYCIN, administration A dosage/ 'VIOMYCIN. adverse effecta 5548. [Tubereuloetatiea. General adverae effects] Mordrain) KR, et al. Ins Z Kim Pharmakol Tber Texlkol 5:499-818, Fob 72 (Ger) ADULT/ AMINOSALICYLIC ACID, adverae effecta/ 'ANTITUBERCULAR AGENTS, adverae effects/ ANTITUBERCULAR AGENTS, toxlctty/ CYCLOSERINE, adverae effects/ DRUG HYPERSENSITIVITY/ DRUG RESISTANCE. MICROBIAL/ ETHAMBUTOL. advene efteeta/ ETHIONAMIDE, adverse effects/ FEMALE/ HUMAN/ ISONIAZID, adverae effects/ KANAMYCIN, adverae efteeta/ MALE/ MIDDLE AGE/ NEOMYCIN, adverae effects/ OXYTETRACYCLINE, adverse effecta/ RIFOMYCIN, adverae effects/ STREPTOMYCIN, advarsa effects/ THIOSEMICARBAZONES. adverae effects/ VIOMYCIN. adverae effecta 5548. The dizzy patient. PapateUa MM. Postgrad Med 82:87-102, Aug 72 DIAZEPAM, therapeutic use/ DRAINAGE/ EAR. injuries/ EAR NEOPLASMS. eompUeationa/ ETHACRYNIC ACID, adverse effect*/ GENTAMICIN, adverae effects/ HEARING DISORDERS, etiology/ HUMAN/ INFLAMMATION. eompUeationa/ KANAMYCIN, adverse effects/ LABYRINTH DISEASES, eompUeationa/ LABYRINTH DISEASES, etiology/ MENIERE'S DISEASE, complications/ MENIERE'S DISEASE, diagnosis/ MENIERE'S DISEASE, drug therapy/ NEOPLASM METASTASIS/ POSTURE/ STREPTOMYCIN, advene effects/ STREPTOMYCIN, therapeutic use/ 'VERTIGO/ VERTIGO, chemicaUy Induced/ VERTIGO, diagnosis/ VERTIGO, etiology/ VERTIGO, surgery/ VESTIBULAR FUNCTION TESTS/ VESTIBULAR NERVE/ VIOMYCIN, adverse effects VIRAL VACCINES ADVERSE EFFECTS 8547. Rubella vaccination during pregnancy. Bolognese 1 il An 1 Obstet Gynecol 112:903-7. 1 Apr 72 ABORTION/ ADOLESCENCE/ ADULT/ ANTIBODIES/ FEMALE/ FETUS, microbiology/ HEMAGGLUTINATION INHIBITION TESTS/ HUMAN/ PLACENTA, microbiology/ PREGNANCY/ 'PREGNANCY COMPLICATIONS, INFECTIOUS, eU"1''*/' RUBELLA, Immunology/ RUBELLA VACCINE, Adverse effects/ 'RUBELLA VIRUS/ OLI 2543 -- DRUGS AND CHEMICALS potassium occurrenco/ POISONING, occurrence/ POLYMERS, poisoning TOXICITY 4500. Organic polymer biocompatibllity and toxicology. Bischoff F. Clin Chem 18:869-04, Sep 72 (241 ref.) ACRYLIC RESINS, therapeutic use/ ANIMAL EXPERIMENTS/ ARTIFICIAL ORGANS/ ASSISTED CIRCULATION/ BIOCOMPATIBLE MATERIALS/ BLOOD COAGULATION/ carcinogens/ cyanoacrylates. therapeutic use/ FREE RADICALS, therapeutic use/ GUINEA PIGS/ HEART, ARTIFICIAL/ HEART VALVE PROSTHESIS/ HUMAN/ INTRAUTERINE DEVICES/ KIDNEY, ARTIFICIAL/ MICE/ PENIS, surgery/ PLASMA SUBSTITUTES, therapeutic use/ POLYMERS, adverse effects/ POLYMERS, therapeutic use/ 'POLYMERS, toxicity/ POLYURETHANES, therapeutic use/ 'PROSTHESIS/ RABBITS/ RATS/ REVIEW/ SILICONES, therapeutic use/ TISSUE ADHESIVES, therapeutic use 4501. (Comparative characteristics of the biological reaction of tissues to polypropylene and lethilan-lavtan sutures] Tiurin VG. et aL Voett Med Zta 10:76-6, Oct 71 (Bus) ANIMAL EXPERIMENTS/ 'POLYMERS, toxicity/ RABBITS/ 'SUTURES, adverse effects POLYMYXIN ADVERSE EFFECTS 4502. [Harmful effects of common drugs on the visual apparatus. Anti-infective drugs. B. Antibiotics] . -Dralands L. Bull Soc Beige Ophtalmol 160:390*421, 1972 (Fre> ADOLESCENCE/ ADULT/ AGED/ 'ANTIBIOTICS, adverse effects/ BLINDNESS, chemically induced/ CEPHALOSPORINS, adverse effects/ CHILD/ CHILD, PRESCHOOL/ CHLORAMPHENICOL, adverse effects/ COLOR BLINDNESS, chemically induced/ DIPLOPIA, chemically induced/ ` 'EYE DISEASES, chemically Induced/ FEMALE/ HUMAN/ MALE/ MIDDLE AGE/ MYOPIA, chemically induced/ OCULOMOTOR PARALYSIS, chemically induced/ OLIGOSACCHARIDES, adverse effects/ OPTIC NEURITIS, chemically induced/ PAPILLEDEMA, chemically induced/ PENICILLIN, adverse effects/ POLYMYXIN, adverse effects/ RETINAL HEMORRHAGE, chemically induced/ 'VISION DISORDERS, chemically Induced POLYNUCLEOTIDES TOXICITY 4503. Hemoatatlc toxicity or Poly I-C. Grololck HR. et xL Toxicol Appl Phxrmocol 23:145*0. Mxy 72 ANIMAL EXPERIMENTS/ * BLOOD COAGULATION, drug effect,/ BLOOD coagulation tests/ disseminated INTRAVASCULAR COAGULATION, chomicsUy Induced/ DOGS/ FACTOR V, inalytu/ FACTOR VII, analyalf/ FACTOR VlII, anxlyili/ FACTOR IX. inalyxli/ FACTOR X. analyst,/ FIBRINOGEN, anxlyslx/ INJECTIONS, INTRAVENOUS/ LEUKOPENIA, chemically Induced/ POLY I-C, administration A dotage/ POLY I*C. toxicity/ -POLYNUCLEOTIDES, toxicity/ PROTHROMBIN TIME/ THROMBOPENIA, chemically induced/ TIME FACTORS POLYURETHANES ADVERSE EFFECTS 4504. Palnta and painted aurfacex. Piper R. Ann Oeenp Hyg 15:111*6, Apr 72 AEROSOLS, adverse effects/ CHILD/ CYANATES, poisoning/ GREAT BRITAIN/ HUMAN/ LEAD POISONING, etiology/ LEGISLATION/ OCCUPATIONAL DISEASES, prevention A control/ -PAINT, adverse effects/ -POLYURETHANES, adverae effects/ SOLVENTS, adverae effects POLYVINYLS ADVERSE EFFECTS 4505. Occupational acrooatcolyali. Markowiu SS, et ml. * Arch Dermatol 106:219-23, Aug 72 ADULT/ BONE RESORPTION, blood/ BONE RESORPTION, blood/ 'BONE RESORPTION, chemically induced/ BONE RESORPTION, diagnosis/ BONE RESORPTION, `pathology/ BONE RESORPTION, pathology/ BONE RESORPTION, radiography/ BONE RESORPTION, radiography/ HAND DERMATOSES, blood/ 'HAND DERMATOSES, chemically Induced/ HAND DERMATOSES, diagnosis/ HAND DERMATOSES, pathology/ HAND DERMATOSES, radiography/ HUMAN/ MALE/ OCCUPATIONAL DERMATITIS, blood/ 'OCCUPATIONAL DERMATITIS, chemically induced/ OCCUPATIONAL DERMATITIS, diagnosis/ OCCUPATIONAL DERMATITIS, pathology/ OCCUPATIONAL DERMATITIS, radiography/ POLYVINYLS, adverse effects/ 'POLYVINYLS, adverse effects POTASSIUM ADVERSE EFFECTS 45M. [Series of studies on heart rhythm disorder*. 5. Potassium and rhythm disorders] Zlpea DP, et aL Coenr Med Interne 11:277*91, Apr-Jun 72 (69 ref.) (Eng. Abatr.) (Fre) ANIMAL EXPERIMENTS/ -ARRHYTHMIA, drug therapy/ DOGS/ ELECTROCARDIOGRAPHY/ ENGLISH ABSTRACT/ FROGS/ -HEART CONDUCTION SYSTEM, drug effect*/ HUMAN/ IN VITRO/ POTASSIUM, administration A dosage/ POTASSIUM, adverse effect*/ -POTASSIUM, therapeutic use/ RABBITS/ REVIEW 4507. (Reversible hepatic encephalopathy provoked by diuretics] Guiltier M. et aL Ear J Toxicol 4:323-7, Jul-Aug 71 (Eng. Abatr.) (Fre) ALKALOSIS, metabolism/ ARGININE, therapeutic use/ CHLOROTHIAZIDE, adverse effects/ -DIURETICS, adverse effect*/ DIURETICS, therapeutic use/ ELECTROENCEPHALOGRAPHY/ ENGLISH ABSTRACT/ ETHACRYNIC ACID, adverse effect*/ FEMALE/ -HEPATIC COMA, chemically induced/ HEPATIC COMA, drug therapy/ HEPATIC COMA, prsventlon 4 control/ HUMAN/ HYPOKALEMIA, metabolism/ LIVER CIRRHOSIS, drug therapy/ LIVER CIRRHOSIS, metabolism/ POTASSIUM, advsrs* effects/ POTASSIUM, metabolism/ POTASSIUM, therapeutic use/ POTASSIUM CHLORIDE, therapeutic use POISONING 4503. (Suicide attempt with potassium cyanide. (Sulcldologic-psychopathologlc presentation)] Kapamadll)* B. NeuropalhljatrM* 18:347-53, 1970 (Eng. Abetr.) (Cro) ADULT/ AFFECTIVE DISTURBANCES, complications/ -CYANIDES, poisoning/ ENGLISH ABSTRACT/ HUMAN/ MALE/ POTASSIUM, poisoning/ PSYCHOPATHOLOGY/ RESUSCITATION/ -SUICIDE TOXICITY 4509. [Development of renal excretion of aodium and potassium in the postnatal period of the rat] Brgunllch H. et al. Acta Biol Med Gar 29:69*98. 1971 (Eng. Abatr.) (Oer) AGE FACTORS/ ANIMAL EXPERIMENTS/ ANIMALS, NEWBORN/ ENGLISH ABSTRACT/ FEMALE/ ION EXCHANGE/ -NATRIURESIS/ POTASSIUM, toxicity/ -POTASSIUM, urine/ RATS/ RATS. INBRED STRAINS/ SODIUM CHLORIDE, pharmacodynamic* POTASSIUM CHLORIDE ADVERSE EFFECTS 4510. Drug-induced malabsorption of vitamin B 12 , IV. Malabsorption and deficiency of B 12 during treatment with slow*release potassium chloride. Palva IP, et al. Acta Med Scand 191:355-7, Apr 72 HEART DISEASES, drug therapy/ HUMAN/ HYDROGEN*!ON CONCENTRATION/ ILEUM/ 'INTESTINAL ABSORPTION, drug effects/ MALABSORPTION SYNDROMES, chemically induced/ MALE/ 'POTASSIUM CHLORIDE, adverse effect*/ SCHILLING TEST/ TELEMETRY/ VITAMIN B 12, blood/ 'VITAMIN B 12 DEFICIENCY, chemically Induced * 4511. [Neurologic accidents after subarachEold'injtctlon of OLI 2544 A-361 polymers DRUGS AND CHEMICALS 33 HYDROGEN-ION CONCENTRATION/ IODINE, diagnostic use/ METHODS/ MICE/ molecular weight/ `polymers. diagnostic me/ POLYMERS, toxicity/ rabbits/ solubility/ water 3*25. Polymera containing pbenethylamlnes. Weiner BE, at tL J Med Cbem 15:410-3, Apr 72 ANIMAL EXPERIMENTS/ BEHAVIOR, ANIMAL, drug effect*/ BLOOD PRESSURE, drug effects/ CATS/ DEPRESSION, CHEMICAL/ FEMALE/ HYDROLYSIS/ INFRARED RAYS/ LETHAL DOSE 50/ MALE/ MICE/ MICE, INBRED STRAINS/ NUCLEAR MAGNETIC RESONANCE/ PHENETHYLAMINES, cbem synthesis/ PHENETHYLAMINES, pharmacodynamics/ PHENETHYLAMINES. toxicity/ `POLYMERS, Cbem synthesis/ POLYMERS, pharmacodynamics/ POLYMERS, toxicity/ RESPIRATION, drug effects/ SPECTRUM ANALYSIS/ STRUCTURE ACTIVITY RELATIONSHIP POLYMYXIN ADVERSE EFFECTS SOOT. [Problems of antibiotic administration In myasthenia gravis] Onlshl A, et al. Adv Neurol Set (Tokyo) 15:000-10. 1071 (Jap) ADULT/ ANTIBIOTICS, administration it dosage/ `ANTIBIOTICS, adverse effects/ BACTERIAL INFECTIONS, drug therapy/ CHOLINESTERASE INHIBITORS, therapeutic use/ FEMALE/ HUMAN/ `MYASTHENIA GRAVIS/ NEUROMUSCULAR DEPOLARIZING AGENTS/ `NEUROMUSCULAR JUNCTION, drug effects/ POLYMYXIN, adverse effects/ PSEUDOMONAS AERUGINOSA/ PSEUDOMONAS INFECTIONS, drug therapy/ TETRACYCLINE, adverse effects POLYNUCLEOTIDES TOXICITY 3000. Ultrastructural changes In chick cerebellum Induced by polylnosinlc polycytldylic acid. Yu MC, ct sL Am J Pathol 04:305-20, Aug 71 ANIMAL EXPERIMENTS/ CELL NUCLEUS/ CEREBELLAR DISEASES. Chemically Induced/ CEREBELLAR DISEASES, pathology/ CEREBELLUM, drug effects/ CEREBELLUM, pathology/ CEREBRAL ARTERIES, pathology/ CHICKENS/ DENDRITES/ ENDOPLASMIC RETICULUM/ MICROSCOPY, ELECTRON/ MICROTUBULES/ MITOCHONDRIA/ NERVE FIBERS, MYELINATED/ POLY I-C, pharmacodynamics/ POLY I-C, toxicity/ `POLYNUCLEOTIDES, toxicity/ PURKINJE CELLS/ RIBOSOMES/ TIME FACTORS POLYSACCHARIDES ADVERSE EFFECTS 3SM. [Fcrric-polymaltosldo. New therapeutic Sid In \ hypochromic anemia of childhood) Sendtm de Si DS, ct aL Rev Braa Med 22:81-4, Feb 72 (Per) `ANEMIA. HYPOCHROMIC, drug therapy/ CHILD/ CHILD, PRESCHOOL/ EVALUATION STUDIES/ FEMALE/ HUMAN/ INFANT/ INJECTIONS, INTRAMUSCULAR/ IRON, administration At dosage/ IRON, adverse effects/ -IRON, therapeutic use/ MALE/ MALTOSE, administration A dotage/ MALTOSE, adverse effects/ MALTOSE, therapeutic use/ POLYSACCHARIDES, administration A dosage/ POLYSACCHARIDES, adverse effects/ `POLYSACCHARIDES, therapeutic use POLYSACCHARIDES, BACTERIAL TOXICITY 3900, [Som* properties of polysaccherlde complexes obtained from cbolera-Uke vibrios] Vvedenskats OI, et al. Zb Hlkrobiol Epidemiol ImmanoMol 49*.39'43, Mar 73 (Bug. Abstr.) (Re*) ANIMAL EXPERIMENTS/ BACTERIAL ANTIGENS/ ENGLISH ABSTRACT/ IMMUNOELECTROPHORESIS/ LETHAL DOSE 50/ MICE/ `POLYSACCHARIDES, BACTERIAL/ POLYSACCHARIDES, BACTERIAL, toxicity/ `VIBRIO POLYURETHANES TOXICITY 3201, Comparison between In vitro toxicity of dusts of certain polymers and minerals and their flbrogentctty. Conning DM, et al. Inhaled Part vap 3:492-500, 1270 ANIMAL EXPERIMENTS/ ASBESTOS, toxicity/ AUTOANALYSIS/ CALCIUM CARBONATE, toxicity/ CELLS, CULTURED, drug effects/ `DUST/ FEMALE/ IN VITRO/ MACROPHAGES, drug effects/ MALE.' `MINERALS, toxicity/ PHTHALIC ACID, toxicity/ POLYETHYLENES. toxicity/ POLYMERS, toxicity/ POLYURETHANES, toxldty/ RATS/ RATS, INBRED STRAINS/ STRUCTURE ACTIVITY RELATIONSHIP/ TIME FACTORS POLYVINYLS POISONING 9901. Cue history: acro-osteolysls. Occep Health (Load) 14:173, May n BONE RESORPTION, chemically Induced/ FINGERS/ OCCUPATIONAL DISEASES, chemically Induced/ POLYVINYLS, poisoning/ SPECIAL UST NURSING POTASSIUM ADVERSE EFFECTS 3203. A gastrointestinal problem. Wilkinson B, et sL Bf Med J 1:727-2. 25 Mar 72 ABDOMEN/ HUMAN/ HYDROCHLOROTHIAZIDE, adverse effects/ HYPERTENSION, drug therapy/ ILEUM, surgery/ `INTESTINAL DISEASES, chemically Induced/ INTESTINAL OBSTRUCTION. , chemically Induced/ MALE/ MIDDLE AGE/ PAIN/ `POTASSIUM, advene effects/ KESEKPINE, adverse effects/ ULCER, chemically induced 3204. [Evaluation of obscure repolarlxatlou disturbances In the electrocardlogrsmm with oral potassium ] Stuts R, et aL Schwels Med Woeheuschr 103:403-5, 25 Mar 73 (Eng. Abetr.) (Car) ADULT/ `ELECTROCARDIOGRAPHY/ ENGLISH ABSTRACT/ FEMALE/ HEART, phytopathology/ `HEART DISEASES, dlaguoala/ HUMAN/ MALE/ MIDDLE AGE/ POTASSIUM, admlniitratlon A dosage/ POTASSIUM, advene effects/ -POTASSIUM, diagnostic use POISONING 3205. [Occupational contact eczema due to potassium gold cyanide] SchmolUck E. / Dermatol Monetaackr 157:811-4, Nev 71 (Eng. Abatr.) / (Ger) CONJUNCTIVITIS, chemically Induced/ CYANIDES, pollening/ `DERMATITIS, CONTACT, etiology/ ECZEMA, chemically Induced/ ENGLISH ABSTRACT/ FACIAL DERMATOSES, chemically Induced/ FEMALE/ GOLD, poisoning/ HAND DERMATOSES, chemically Induced/ HUMAN/ HYPERSENSITIVITY/ OCCUPATIONAL DERMATITIS, chemically Induced/ POTASSIUM, pollening/ SKIN TESTS/ TIME FACTORS TOXICITY 3205. Effect! of nicotine and sympathomimetic amines on potassium lntoxlcstion. Lum BK, et il. J Pharmacol Exp Thar 181:147-54, Apr 72 ADRENERGIC ALPHA RECEPTOR AGONISTS, pharmacodynamics/ ADRENERGIC BETA RECEPTOR AGONISTS, pharmacodynamics/ ANIMAL EXPERIMENTS/ ATROPINE, pharmacodynamics/ BLOOD PRESSURE, drug effects/ -CATECHOLAMINES, pharmacodynamics/ CATS/ CHLORISONDAMINE, pharmacodynamics/ DOGS/ ELECTROCARDIOGRAPHY/ EPINEPHRINE, pharmacodynamics/ FEMALE/ HEART RATE, drug affects/ ISOPROTERENOL, pharmacodynamics/ MALE/ NEPHRECTOMY/ `NICOTINE, pharmacodynamics/ PHENOXYBENZAMINE, Pharmacodynamics/ PHENYLEPHRINE, Pharmacodynamics/ POTASSIUM, antagonists A Inhibitors/ POTASSIUM, blood/ `POTASSIUM, toxicity/ PROPRANOLOL, pharmacodynamics/ L'-'' A-296 OIiI 2545 VINCRISTINE DRUGS AND CHEMICALS jV PRESCHOOL/ CORTICOSTERONE, therapeutic us/ CYCLOPHOSPHAMIDE, advene effect*/ CYCLOPHOSPHAMIDE, therapeutic use/ rEHALi/ human; inpant/ jaundice. chemically Induced/ LEUKOPENIA, chemically Induced/ MALE/ RETICULOENDOTHELIOSIS, <3rut therapy/ SULFATES/ VINBLASTINE, advene effecta/ `VINBLASTINE, therapeutic ace/ VINCRISTINE, advene effecta/ VINCRISTINE, therapeutic uae 4756. Combination Chemotherapy (MOPP) In the management of advanced Hodgkin's dlaeaae A progress report on 55 patients. Cooper IA, et aL Med J Anal 1.81-9, 8 Jan 72 ADOLESCENCE/ ADRENAL CORTEX HORMONES, therapeutic uae/ ADULT/ BENZOATES, thenpeutlc nee/ BONE AND BONES, radloraphy/ DRUG COMBINATIONS/ FEMALE/ `HODGKIN'S DISEASE, drug therapy/ HODGKIN'S DISEASE, pathology/ HODGKIN'S DISEASE, radiotherapy/ HUMAN/ LIVER FUNCTION TESTS/ LUNG, radlofraphy/ MALE/ MECHLORETHAM1NE, admlnlatratlon A doeace/ MECHLORETBAMINE, advene effect!/ MECHLORETHAMINX. therapeutic see/ MIDDLE AGE/ PREDNISOLONE, admlnletntton A doeace/ PREDNISOLONE, adverse effecta/ 'PREDNISOLONE, therapeutic uae/ PROCARBAZINE, administration a doaaga/ PROCARBAZINE, advene effect*/ PROCARBAZINE, therapeutic use/ VINCRISTINE, admlnlatratlon A dosage/ VINCRISTINE, advene affect*/ VINCRISTINE, therapeutic see 4759. [Vincristine-Induced encephalopathies during treatment of childhood lenkomlu] Grfibo H, at al. , Moentsaehr KlsdarheUkd 120:11-7, Jan 71 (Eng. / Abstr.) (Ocr) ALBUMINURIA/ CENTRAL NERVOUS SYSTEM, drui effects/ CHILD/ CHLORIDES, blood/ `CONVULSIONS, chemically induced/ ELECTROENCEPHALOGRAPHY/ ENGLISH abstract/ female/ human/ `leukemia, LYMPHOBLASTIC, dim* therapy/ POTASSIUM, blood/ SODIUM, blood/ SPECIFIC GRAVITY/ UNCONSCIOUSNESS, chemically Induced/ UREA, urine/ URINE/ `VINCRISTINE, adverse effects/ VINCRISTINE, therapeutic nee 47(0. Vincristine neurotoxicity. Weldon PL et aL N Enel J Med 2M.-1MP-70, 23 Jon 72 . HUMAN/ MALE/ MIDDLE AGE/ `MUSCULAR ATROPHY, complications/ `NERVOUS SYSTEM, dru* effects/ NERVOUS SYSTEM DISEASES, chemically Induced/ PARAPLEGIA, chemically Induced/ PARESTHESIA, chemically Induced/ TERATOID TUMOR, dru* tbenpy/ TESTICULAR NEOPLASMS, diu therapy/ VINCRISTINE, adverse effecta 47(1. IoniaIn* radiation end vincristine: poealble neurotonic syaerflsm. Byfleld JE. Radiol CUn HIM 41:129-58,1971 COBALT ISOTOPES, therapeutic u*e/ CYCLOPHOSPHAMIDE, admlniatratinn A doss**/ CYCLOPHOSPHAMIDE, thenpeutlc uae/ DRUG SYNERGISM/ HUMAN/ INFANT/ . INFANT, NEWBORN/ MALE/ MEDIASTINAL NEOPLASMS, drus therapy/ MEDIASTINAL NEOPLASMS, radiotherapy/ `MYELITIS, etiology/ NEURAL CONDUCTION/ NEUROBLASTOMA, drug therapy/ NEUROBLASTOMA, radiotherapy/ RADIATION-SENSITIZING AGENTS/ RADIOTHERAPY DOSAGE/ `RADIOTHERAPY. HIGH ENERGY, adverse effects/ VINCRISTINE, admlnlatratlon A doaaga/ VINCRISTINE, advene effects/ VINCRISTINE, thenpeutlc use 4782. [Studlee on the ncurctlxlclty of vincristine In the course of Infantile leukemia) Min L et aL RlV Patol Narv Meat 91:189-48, Jun 70 (Eng. Abatr.) (tea) child, preschool/ drug tolerance/ ENGLISH ABSTRACT/ FEMALE/ HUMAN/ LEUKEMIA, drus therapy/ MOTOR NEURONS, drug effects/ `NERVOUS SYSTEM DISEASES, chemically induced/ QUADRIPLXGIA. chemically induced/ VATER'S AMPULLA, drug effects/ VINCRISTINE, advene effect! VINYL COMPOUNDS POISONING 4743. [Ftthofuaesia of tb eteng0* dv*loplaf 1a loug-trm A-364 77/. xpotur* to vinyl chloride] Bat*l**v AV, *t iL Oil Tt Prof Zftfcol 16:24-7, Feb 72 (Eng. Abstr.) (Ri) ALKENES, polionlDtf/ ANIMAL EXPERIMENTS/ ARTERIES/ BLOOD PRESSURE/ BONE RESORPTION, chemically Induced/ CEREBRAL CORTEX, Physiology/ CHLORIDES, poisoning/ ELECTROCARDIOGRAPHY/ ENGLISH ABSTRACT/ HYPOTHALAMUS, Physiology/ PHONOCARDIOGRAPHY/ PULSE/ RABBITS/ RATS/ VINYL COMPOUNDS, poisoning TOXICITY 4764. A laboratory model for behaviour as an Indicator of tonicity. Silverman AP. Cite Pound Study Group 25:26-40, 1070 ACETATES, toxicity/ ALKENES, toxicity/ ANIMAL EXPERIMENTS/ ANIMALS. LABORATORY/ *BEHAVfOR, ANIMAL, drug effects/ CHEMICAL INDUSTRY/ DISEASE MODELS, ANIMAL/ ENVIRONMENTAL EXPOSURE/ HUMAN/ MALE/ NICOTINE, administration a dotage/ NICOTINE, toxicity/ RATS/ SMOKING/ SOCIAL BEHAVIOR, drug effects/ TAPE RECORDING/ 'TOXICOLOGY/ VINYL COMPOUNDS, toxicity 47CS. [Toxic effect on the organism of simultaneous air poUutlon by vinylacetate and acetaldehyde] PrisUxhAiufc VE. Gig Sanit 26:12-6, Dee 71 (Eng. Abstr.) (Rus) ACETALDEHYDE, toxldty/ ACETIC ACIDS, toxicity/ *AIR POLLUTION/ *ALKENES, toxicity/ ANIMAL EXPERIMENTS/ ENGLISH ABSTRACT/ ENVIRONMENTAL EXPOSURE/ HUMAN/ MAXIMUM PERMISSIBLE EXPOSURE LEVEL/ RATS/ TIME FACTORS/ VINYL COMPOUNDS, toxicity VIRAL VACCINES ADVERSE EFFECT* 47(4. Joint eymptome following an eree-wlde rubella humanization campalgfi-report of a aurvoy. Wallace JUk at al. Am J Fublie Hoallh 42:458-51, May 72 AGE FACTORS/ ANTIBODIES, analyst,/ CHILD/ CHILD. PRESCHOOL/ COMPARATIVE STUDY/ FEMALE/ HEMAGGLUTINATION INHIBITION TESTS/ HUMAN/ JOINT DISEASES. Mood/ 'JOINT DISEASES, otlolagy/ JOINT DISEASES, Immunology/ MALE/ NEW YORK/ PAIN, otiology/ RETROSPECTIVE STUDIES/ RUBELLA, immunology/ `RUBELLA, provuntloo A control/ RUBELLA VACCINE, edvereo effecta/ `RUBELLA VIRUS/ SCHOOL HEALTH/ TIME FACTORS/ `VIRAL VACCINES, advene effecta 47*7. Bronchial aenaltlvlty to mothacDollne after liver rubella vaccine immunization in aathmatle children. TRcbinda M, et al. Aa* AUer,y 80:142-5, Mar 72 ADOLESCENCE/ ANTIBODIES, aaalyals/ ASTHMA, Immunology/ CHILD/ FEMALE/ HEMAGGLUTINATION INHIBITION TESTS/ HUMAN/ MALE/ ,'METHACHOLINE COMPOUNDS. diagnostic uae/ RESPIRATORY AIRFLOW/ RESPIRATORY HYPERSENSITIVITY, dlaguoel*/ RUBELLA VACCINE, advert* effect!/ 'RUBELLA VIRUS. Immunology/ 'VIRAL VACCINES, advene effecte 4768. Lack of significant oncogenicity of hloloftcal products In hamsters. Cox CB, at *L Appl MlcroMel 28:87m, Apr 72 ADENOMA, chemically Induced/ ADENOVIRUS/ ADRENAL GLAND NEOPLASMS, chemically Induced/ ANIMAL EXPERIMENTS/ ANIMALS, NEWBORN/ BACTERIAL ANTIGENS, advene effects/ BACTERIAL VACCINES, adverse effect!/ BIOLOGICAL PRODUCTS, adverse effects/ CARCINOGENS/ DISEASE MODELS, ANIMAL/ FEMALE/ 'HAMSTERS, drug offsets/ NEOPLASMS. EXPERIMENTAL, chemically Induced/ ORGAN SPECIFICITY/ PREGNANCY/ SV48 VIRUS/ TOXOIDS, adverse effect!/ VIRAL VACCINES, advene effects 87*9. Clinical reactivity and lmmunogenlclty of hemagglutinin influenza vaccine, II. Clinical reactions, bemagglutlnatlon-tnblbitloag and strain and type-specific complement-filing antibody responsea in Infants. Zlvadovd H. et al. Arch Geaamte Vlmafoncb 38:53-81, 1972 ANTIBODIES, analyaic/ ANTIBODY OLI 2546 I POLYSTYRENES DRUGS AND CHEMICALS blood/ HUMAN/ HYDROGEN-ION CONCENTRATION/ HYDROXIDES, administration & dosage/ HYDROXIDES, adverse effects/ *ION EXCHANGE RESINS, administration A dosage/ ION EXCHANGE RESINS, adverse effects/ MAGNESIUM, administration A dotage/ MAGNESIUM, adverae effect!/ MAGNESIUM, blood/ MALE/ POLYSTYRENES, administration A dosage/ POLYSTYRENES, adverae effects/ POTASSIUM, blood/ SULFONIC ACIDS, administration * dotage/ SULFONIC ACIDS, adverae effects 3606. (Evaluation of color perception disturbances In apprentices in a chemical plant producing butadlene-Styrol-rubber sod polysterol] Klein O, et aL Z Gesamte Hyg 17:492-6. Ju1 71 (Ger) ADOLESCENCE/ * BUTADIENE, adverse effects/ -COLOR PERCEPTION/ COLOR PERCEPTION TESTS/ FEMALE/ HUMAN/ INDUSTRIAL MEDICINE/ MALE/ -OCCUPATIONAL DISEASES, diagnosis/ -POLYSTYRENES, adverae effects/ -VISION DISORDERS, chemically Induced POLYURETHANES TOXICITY MOT. TorJcttr ot iuh releaaetf by polyxir.th.ne faux objected to eatflcleaUy hlfh temper,tur.. Yamamoto K. et L lap j Leg Med 25:003*14, Jul Tl ANIMAL EXPERIMENTS/ CARBON MONOXIDE, blood/ CARBON MONOXIDE POISONING/ CYANIDES, blood/ CYANIDES, polronlni/ "CAS POISONING, etlolofy/ GAS POISONING, mortality/ `BEAT/ HEMOGLOBIN, an.ly.Ii/ MALE/ OXYGEN. *o*ly(l*/ `POLYURETHANES, toxicity/ RATS POLYVINYLS adverse effects 3M0. [Bebevlor of the bnnua liver durlnf Mllcoel* tbermpy ulus .POlyvlaylpyrldlBe-N-exlde (PVNO)l Bee, P, et it Beltr suuoeetonel) 23:1-1M, 1*71 (End. Abetr.) (Ger) BIOPSY/ ENGLISH ABSTRACT/ HUMAN/ LIVER, aetebolira,/ `LIVER, phytopathology/ MALE/ OXIDES/ POLYVINYLS, tdverM effect./ `POLYVINYLS, meubollnn/ POLYVINYLS, therapeutic ale/ PYRIDINES, .dvene effect./ `PYRIDINES, metabolixm/ PYRIDINES. therapeutic uie/ `SILICOSIS, drud therapy/ TIME FACTORS 3*09. Enteroeolitl* following exchange tranafualon. Super M. Lencel 3:1303-4. 27 Nov 71 BICARBONATES, advene effect*/ ENTEROCOLITIS, ACUTE, etlolofy/ EXCHANGE TRANSFUSION, .dvene effect./ HUMAN/ INFANT. NEWBORN/ `INFANT, NEWBORN, DISEASES, ctlolody/ POLYVINYLS, advene effect. M10, PleatlcUera In P.V.C. and the occurr.no* of bepetltl* in e haemodlalyala unit. A preliminary communication. Naergaard J, et *1. Scans J Urol Nephrol 5:141*3,1*71 ADULT/ AMINOTRANSFERASES, blood/ ANTIGEN-ANTIBODY REACTIONS/ BILIRUBIN, blood/ CARBON TETRACHLORIDE, enlyit*/ DYSPNEA, chemically Induced/ FEMALE/ FEVER, chemically Induced/ GLOMERULONEPHRITIS, complication./ GLOMERULONEPHRITIS, therapy/ `HEMODIALYSIS/ `HEPATITIS, TOXIC/ HEPATOMEGALY, chemically Induced/ HUMAN/ KIDNEY FAILURE, CHRONIC, therapy/ LACTATE DEHYDROGENASE, blood/ LIVER, p.tholofy/ MALE/ NAUSEA, chemically induced/ NEPHRECTOMY/ PAIN, chemically Induced/ PHTHAXJC ACID, advene effecte/ POLYVINYLS, adverae effect./ POLYVINYLS, uuly.li/ POSTOPERATIVE COMPLICATIONS TOXICITY MU. DcocoUtl. followln* exchande traufuMon. McCaadlew AE. Lancet 2:732. 2 Oct 71 COLITIS, etiology/ `EXCHANGE TRANSFUSION, adverse effects/ HUMAN/ ILEITIS, etlolofy/ POLYVINYLS, toxicity A-290 S' & / POTASSIUM ADVERSE EFFECTS 3612. Scabies. Wilson JW. Arch Dermatol 104:223. Aug 71 BIOPSY/ FECES, drug effects/ HUMAN/ -HYDROXIDES* adverae effects/ -INDICATORS AND REAGENTS/ POTASSIUM, adverae effects/ -SARCOPTES SCAB1EI, drug effects/ -SCABIES, diagnosis/ SODIUM CHLORIDE/ SOLUTIONS 3613. t Sodium dust effects and elimination procedures in the respiratory tract] Gall* E. at at Z Erkr Atmuufsorgnne 134:469-70, 1971 (Ger) ANIMAL EXPERIMENTS/ *DUST/ ENVIRONMENTAL EXPOSURE/ ENVIRONMENTAL POLLUTION/ INDUSTRIAL MEDICINE/ NASAL MUCOSA, drug effects/ NASAL SEPTUM* drug offecu/ NOSE, secretion/ PHAGOCYTOSIS/ POTASSIUM, advene effects/ RABBITS/ -RESPIRATORY SYSTEM, drug effects/ -SODIUM, adverse - effects POISONING 3614. Treatment of caustic alkali poisoning. Arena JM. Mod Treat 6:613-8, Aug 71 (11 ref.) ACCIDENTS, HOME/ ACETIC ACIDS, therapeutic use/ ADRENAL CORTEX HORMONES, therapeutic use/ -ALKALIES, poisoning/ BURNS. CHEMICAL, etiology/ BURNS, CHEMICAL, therapy/ CARBONATES, poisoning/ -CAUSTICS, poisoning/ DILATATION/ ESOPHAGOSCOPY/ ESOPHAGUS, Injuries/ EYE BURNS, etiology/ EYE BURNS, therapy/ HUMAN/ HYDROXIDES, poisoning/ IRRIGATION/ PEROXIDES, poisoning/ POTASSIUM, poisoning/ PREDNISOLONE, therapeutic use/ REVIEW/ SODIUM, poisoning/ SODIUM HYDROXIDE* poisoning/ SODIUM HYPOCHLORITE, poisoning POTASSIUM CHLORIDE ADVERSE EFFECTS 3619, [Arrhythmias. 3, Digitalis induced arrhythmia] Bertler A* et aL LakaiUdalngen 68:$uppl 11:66-, 14 Jun 71 (Sve) ADRENERGIC BETA RECEPTOR BLOCKADERS, therapeutic use/ ANTIDOTES/ -ARRHYTHMIA, chemically induced/ ARRHYTHMIA, drug therapy/ CALCIUM, therapeutic use/ -DIGITALIS GLYCOSIDES, adverse effects/ D1GOXIN, adverse effects/ DtPHENYLHYDANTOIN, therapeutic use/ HEART CONDUCTION SYSTEM, drug effects/ HUMAN/ L1DOCA1NE, therapeutic use/ POTASSIUM CHLORIDE, adverse effects 9616, [Use of potassium chloride in cardiovascular diseases) KetelaL hot Med 33:102-6, Nov 70 (Eng. Abstr.) (Rus) ADMINISTRATION, ORAL/ ADULT/ -ARRHYTHMIA, chemically induced/ -CORONARY DISEASE* drug therapy/ -DYSPEPSIA, chemically induced/ ENGUSH ABSTRACT/ FEMALE/ -HEMORRHAGE, GASTROINTESTINAL, chemically induced/ HUMAN/ INTESTINE, SMALL/ MALE/ MIDDLE AGE/ POTASSIUM CHLORIDE, administration A dosage/ -POTASSIUM CHLORIDE, adverse effects/ -ULCER, chemically induced POWDERS ADVERSE EFFECTS 3617. Prophylaxis of Found Infection. Stoker TA, et aL Br Med J 3:769, 25 Sep 71 AMPICILLIN, therapeutic use/ ANTIBIOTICS, adverse effects/ -ANTIBIOTICS, therapeutic use/ CLINICAL RESEARCH/ HUMAN/ POWDERS, adverse effects/ SUPPURATION, chemically Induced/ -SURGICAL WOUND INFECTION, prevention A control/ UREA, adverse effects/ -UREA, therapeutic use PREDNISOLONE ADVERSE EFFECTS 3618. [Steroid induced glaucoma] Sato N, Acta So* Ophthalmol Jap 75:1288-98, Jun 71 (Eng, Abstr.) (Jap) ADULT/ AGE FACTORS/ -BETAMETHASONE, adverae effect#/ CHILD/ CORTISONE, adverse OLI 2547 DRUGS AND CHEMICALS PREDNISOLONE poisoning 3424. [Toxic trigeminal disease and polyvinyUdene chloride] Krieger J, et M. Rev Otoneuroophtalmol 43:84-8, Jan-Feb 71 (Frc) ADULT/ HUMAN/ MALE/ `POLYNEURITIS, etiology/ 'POLYVINYLS, poisoning/ TRIGEMINAL NERVE TOXICITY 8425. [Detoxicating effect* of poly-2-vlnylpyrldlne-N*oxide] Antweller H. Beltr Sllikostforteh 22:93-172, 1970 (Ger> ANAPHYLAXIS, drug therapy/ ANIMAL EXPERIMENTS/ `ANTIDOTES/ CARBON TETRACHLORIDE POISONING, prevention * Control/ ENGLISH ABSTRACT/ ENZYME TESTS/ ERYTHROCYTES, drug effects/ FISHES/ FUNGI/ GUINEA PIGS/ HEMOLYSIS/ MICE/ OXIDES, pharmacodynamics/ OXIDES, therapeutic use/ `POISONING, drug therapy/ POLYVINYLPYRROLIDONE, pharmacodynamics/ 'POLYVINYLS, pharmacodynamics/ POLYVINYLS, therapeutic nse/ POLYVINYLS, toxicity/ 'PYRIDINES, pharmacodynamics/ PYRIDINES, therapeutic nse/ RABBITS/ RATS/ SILICA, antagonists * Inhibitor*/ SILICOSIS, drug therapy/ SILICOSIS, prevention & control/ SWINE/ URETHANE, pharmacodynamics POTASSIUM ADVERSE EFFECTS 842$. [Relationship between the extracellular potassium concentration, electrocardiographic excitatory ,prooessand functional cardiac capacity] Schwarzbach " W, Arch Kreislaufforsch $3:123*51, Nov-Dec 70 (Gcr) ADMINISTRATION, ORAL/ ADULT/ AGED/ ARRHYTHMIA, chemically Induced/ CARDIAC OUTPUT, drug effects/ CARDIAC VOLUME, drug effects/ DIURETICS, diagnostic nse/ 'ELECTROCARDIOGRAPHY/ ENGLISH ABSTRACT/ 'HEART, physiology/ HEART CONDUCTION SYSTEM, drug effects/ HEART FAILURE. CONGESTIVE, blood/ HEART FAILURE. CONGESTIVE. Complications/ 'HEART FAILURE, CONGESTIVE, phyilopathology/ HEART FUNCTION TESTS/ HEART RATE, drug effects/ HUMAN/ HYPOKALEMIA, complications/ HYPOKALEMIA phyilopathology/ MIDDLE AGE/ POTASSIUM, adverse effects/ 'POTASSIUM, blood/ POTASSIUM, diagnostic use/ POTASSIUM, pharmacodynamics/ STATISTICS 8427. Low sodium diet. A personal experience of its benefits and pleasures, Youngstrom KA. J Kana Med Sec 72:253*4, Jun 71 'CEREBROVASCULAR DISORDERS, therapy/ CHLOROTHIAZIDE, adverse effects/ 'DIET, SALT-FREE/ HUMAN/ METHYLDOPA. adverse effect*/ POTASSIUM, adverse effect* 242$. The effect of potassium perchlorate on the uptake of MmTc-pertechnetate la choroid plexns papillomas; a report of two cases. Fagan JA, et aL 3 Ned Med 12:312-4. Jun 71 CEREBRAL VENTRICLE NEOPLASMS, diagnosis/ CEREBRAL VENTRICLE NEOPLASMS, metabolism/ CHILD/ 'CHOROID PLEXUS, metabolism/ DEPRESSION, CHEMICAL/ FEMALE/ HUMAN/ INFANT/ MALE/ 'PAPILLOMA diagnosis/ PAPILLOMA metabolism/ 'PERCHLORIC ACIDS, adverse effects/ PERCHLORIC ACIDS, diagnostic use/ POTASSIUM, adverse effect*/ POTASSIUM, diagnostic use/ 'RADIOISOTOPE SCANNING/ RADIOISOTOPES, metabolism/ TECHNETIUM, metabolism POTASSIUM CHLORIDE ADVERSE EFFECTS 842$. Side-effects of potassium chloride In products with different dissolution rates. Graffner C, et aL Aeta Fharm Sate 8:19-28, Mar 71 ADULT/ CAPSULES/ COMPARATIVE STUDY/ DELAYED-ACTION PREPARATIONS/ FEMALE/ GASTROINTESTINAL SYSTEM, drug effects/ HUMAN/ MALE/ MIDDLE AGE/ PLACEBOS/ 'POTASSIUM CHLORIDE, adverse effect*/ TABLETS 3480. Fatal drug reactions among medical Inpatients. Shapiro , S, et aL JAMA 218:487-72, 19 Apr 71 ADMINISTRATION. ORAL/ AGED/ ASPARAGINASE, adverse effects/ DRUG HYPERSENSITIVITY, etiology/ DRUG INCOMPATIBILITY/ DRUG THERAPY, adverse effect*/ 'DRUG THERAPY, mortality/ DRUGS, administration A dosage/ FEMALE/ HOSPITALIZATION/ HUMAN/ HYPERKALEMIA, chemically induced/ INFUSIONS. PARENTERAL, adverse effects/ INJECTIONS/ MALE/ MEOICATION ERRORS/ MIDDLE AGE/ POTASSIUM CHLORIDE, adverse effect*/ PULMONARY EDEMA, chemically Induced POWDERS ADVERSE EFFECTS 3431. [Long-term studies following application of various glove powders] Ptelstlcker K, et aL Chlrnrg 41:232-3, May 70 (Ger) ABDOMEN/ ADHESIONS, chemically Induced/ ANIMAL EXPERIMENTS/ DERMATITIS, CONTACT, etiology/ ENGLISH ABSTRACT/ FOLLOW-UP STUDIES/ 'GLOVES, SURGICAL/ GRANULOMA, chemically induced/ POWDERS, adverse effects/ RATS/ STARCH, adverse effects/ TALC, adverse effects PREDNISOLONE ADVERSE EFFECTS 3482. [A case of glaucoma induced by short-term systemic steroid therapy] Gl S. et aL Acta See Ophthalmol Jap 78:344-$, 20 Jan 71 (Jap) ADMINISTRATION, ORAL/ CASE REPORT/ CHILD/ ENGLISH ABSTRACT/ FEMALE/ GLAUCOMA, chemically induced/ HUMAN/ INTRAOCULAR PRESSURE/ PREDNISOLONE, administration Sc domge/ 'PREDNISOLONE, adverse effects 3433. A study of the effects of corticosteroids on blood coagulation In rabbits. Mlshra KC, et aL Indian J Med Scl 25:154*7, Mar 71 ANIMAL EXPERIMENTS/ BETAMETHASONE, adverse effects/ 'BLOOD COAGULATION DISORDERS, chemically Induced/ CORTISONE, adverse effects/ 'GLUCOCORTICOIDS, adverse effects/ HYDROCORTISONE, adverse effects/ PREDNISOLONE, adverse affects/ RABBITS 3434. [Gray cataract caused by cortleosteroids] Molnir L, et aL Klin MonatsN Angtnhellkd 158:578-84, Apr 7! (Gr) CATARACT, chemically Induced/ CATARACT, diagnosis/ ENGLISH ABSTRACT/ FEMALE/ HUMAN/ MALE/ MIDDLE AGE/ PREDNISOLONE, advene affects 1485. Management at chronle hepatitis. Lancet 1:1221-8, 12 Jon 71 AZATJUOPRINE, therapeutic u*e/ CHRONIC DISEASE/ FEMALE/ 'HEPATITIS, drug therapy/ HEPATITIS, INFECTIOUS, complications/ HEPATITIS, TOXIC, complications/ HUMAN/ MALE/ PREDNISOLONE, adverse affects/ PREDNISOLONE, therapeutic use/ PREGNANCY 3438. (Catenet caused by corticosteroids] Molnir L, at aL Orv Hattl 112:799-800, 4 Apr 71 (Hun) CATARACT, chemically induced/ FEMALE/ HUMAN/ MALE/ MIDDLE AGE/ PREDNISOLONE, advene effects 3487. Advantages of prednisolone ftesroylglycolate In chronic steroid-dependent asthma. Flue* A, Practitioner 208:513-8, Apr 71 ADOLESCENCE/ ADULT/ AGED/ ASTHMA, drug thenpy/ BODY WEIGHT/ CHILD/ - CHRONIC DISEASE/ CLINICAL RESEARCH/ COMPARATIVE STUDY/ FEMALE/ HUMAN/ MALE/ MIDDLE AGE/ 'PREDNISOLONE, administration A dosage/ PREDNISOLONE, advene effects/ `STEARIC ACID, administration it dosage/ STEARIC ACID, advene effect*/ TABLETS, ENTERIC-COATED 3438. Side affects of long term steroid thenpy in chronic lung disease. Kerrebljn KF. Respiration 27:Suppl:230-l, 1970 `ASTHMA, drug therapy/ CHILD/ CORTICOTROPIN, diagnostic use/ ETHYLESTRENOL, pharmacodynamics/ `GROWTH, drug effects/ GROWTH DISORDERS, chemically Induced/ HUMAN/ A-251 OLI 2548 VINCRISTINE DRUGS AND CHEMICALS 31. EPILEPSY, cerebrospinal fluid/ 'EPILEPSY, chemically Induced/ FEMALE/ HUMAN/ LEUKEMIA, drug therapy/ MALE/ * VINCRISTINE, adverse effects 4096. [Blast cell leukemia with bullous lesions) Degos R, et aL Bull Soe Fr Dermatol Syphlllgr 76:270-1, I960 (Fre> BIOPSY/ BLISTER/ CASE REPORT/ HUMAN/ LEUKEMIA/ 'LEUKEMIA, pathology/ MALE/ MIDDLE AGE/ POLYNEURITIS, chemically Induced/ SKIN, pathology/ VINCRISTINE, adverse effects 4097. Combined actlnomycin D and vincristine In tbe treatment of patients with cancer. Chanes RE. et aL Cancer 27:613-7, Mar 71 BREAST NEOPLASMS, drug therapy/ 'DACTINOMYCIN, administration A dosage/ DACTINOMYCIN, adverse effects/ HUMAN/ LUNG NEOPLASMS, drug therapy/ MELANOMA, drug therapy/ 'NEOPLASMS, drug therapy/ SARCOMA, drug therapy/ 'VINCRISTINE, administration A dosage/ VINCRISTINE, adverse effects 4098. Vincristine, prednisone, and daunomyctn ^.in acute leukemia of childhood. Vlettl TJ. et aL Cancer 27;6Q2*7, Mar 71 ACUTE DISEASE/ ADOLESCENCE/ BLOOD CELL COUNT/ BONE MARROW CELLS, drug effects/ CHILD/ COMPARATIVE STUDY/ DAUNOMYCIN, administration A dosage/ DAUNOMYCIN, adverse effects/ 'DAUNOMYCIN, therapeutic use/ HUMAN/ 'LEUKEMIA, drug therapy/ LEUKEMIA, LYMPHOBLASTIC, drug therapy/ LEUKEMIA. . MONOBLASTIC, drug therapy/ LEUKEMtA, / MYELOBLASTIC, drug therapy/ LEUKOCYTE COUNT/ PREDNISONE, administration A dosage/ PREDNISONE, adverse effects/ 'PREDNISONE, therapeutic use/ VINCRISTINE, administration A dosage/ VINCRISTINE, adverse effects/ VINCRISTINE, therapeutic use 4099. (Vincristine polyneuritis] Dsun H, et aL Fortschr Neurol Psychlatr 39:jSl-65, Mar 71 (Ger) ADULT/ AGED/ BONE NEOPLASMS, drug therapy/ FEMALE/ HODGKIN'S DISEASE, drug therapy/ HUMAN/ LYMPHOSARCOMA, drug therapy/ MALE/ MIDDLE AGE/ 'POLYNEURITIS, chemically induced/ SARCOMA, OSTEOGENIC, drug therapy/ VINCRISTINE, administration A dosage/ 'VINCRISTINE, adverse effects 4100. [Side effects of drugs. 4. Drug induced polyneuropathies and myopathies] Johansson B. Lakartidningen 66:Suppi IV:77+, 10 Dec 69 (86 ref.) CHLOROQUINE, adverse effects/ (Swe) CORTICOTROPIN, adverse effects/ GLUCOCORTICOIDS, adverse effects/ HUMAN/ HYDRALAZINE, adverse effects/ ISONIAZTD, adverse effects/ MUSCULAR DISEASES, chemically Induced/ NEURONS, AFFERENT, physlopsthology/ NITROFURANS, \ adverse effects/ 'PERIPHERAL NERVE DISEASES, chemically Induced/ REVIEW/ THALIDOMIDE, adverse effects/ VINCRISTINE, adverse effects 4101. Neurological complications of systemic cancer. Posner JB. Med CUa North Am 55:823-46, May 71 (31 ref.) ADRENAL CORTEX HORMONES, adverse effects/ ADRENAL CORTEX HORMONES, therapeutic use/ ADULT/ AGED/ ASPARAGINASE, adverse effects/ BRAIN DISEASES, etiology/ BRAIN NEOPLASMS, complications/ BRAIN NEOPLASMS, drug therapy/ BRAIN NEOPLASMS, radiotherapy/ CERVIX NEOPLASMS, complications/ electroencephalography/ FEMALE/ GLUCOCORTICOIDS, therapeutic use/ HUMAN/ INFECTION, etiology/ MALE/ MELANOMA, complications/ MENINGES/ METABOLIC DISEASES, etiology/ MIDDLE AGE/ MYELOGRAPHY/ NEOPLASM METASTASIS/ NEOPLASM METASTASIS, diagnosis/ 'NEOPLASMS, complications/ 'NEOPLASMS, NERVOUS TISSUE, complications/ NEOPLASMS, NERVOUS TISSUE, diagnosis/ NERVE COMPRESSION, etiology/ 'NERVOUS SYSTEM DISEASES, etiology/ 'NEUROLOGIC MANIFESTATIONS/ PERIPHERAL NERVE DISEASES, etiology/ RADIATION INJURY/ REVIEW/ SPINAL CORD COMPRESSION, etiology/ SPINAL CORD NEOPLASMS, compUcatiooa/ SPINAL CORD NEOPLASMS, drug therapy/ SPINAL A-302 T^v jLuu. CORD NEOPLASMS, radiography/ VINCRISTINE, adverse effects 4102, [Experience with vincristine sulfate] Hartwich G, et al. Med Welt 17:706-12, 24 Apr 71 (Ger) ADULT/ AGED/ FEMALE/ 'HODGKIN'S DISEASE, drug therapy/ HUMAN/ 'LEUKEMIA, drug therapy/ 'LYMPHOMA, drug therapy/ MALE/ MIDDLE AGE/ POLYNEURITIS, chemically induced/ SULFATES, therapeutic use/ VINCRISTINE, adverse effects/ 'VINCRISTINE, therapeutic 4103. [ Effects of repetitive stimulations during neuropathiea due to vincristine. Preliminary observations] Metral S, et aL Rev Neurol (Parts) 123:275-9, Oct 70 (Fre) CHILD/ CHILD, PRESCHOOL/ ELECTROMYOGRAPHY/ FEMALE/ HUMAN/ INFANT/ MALE/ 'NEPHROBLASTOMA, drug therapy/ 'NEURAL CONDUCTION/ 'NEUROBLASTOMA, drug therapy/ NEUROMUSCULAR DISEASES, chemically Induced/ NEUROMUSCULAR DISEASES, phytopathology/ VINCRISTINE, administration It dosage/ 'VINCRISTINE, adverse effects VINYL COMPOUNDS ADVERSE EFFECTS 4104. [Effect of histamine on tbe main functions of the stomach in anacid gastritis in persons working with aromatic hydrocarbons] Bashirov AA_ Ter Arkh 42:41-4, Dec 70 (Rus) 'ACHLORHYDRIA, chemically Induced/ ADULT/ AIR POLLUTION/ 'ALKENES, adverse effects/ ENGLISH ABSTRACT/ ENVIRONMENTAL EXPOSURE/ FEMALE/ 'GASTRITIS, Chemically induced/ GASTRITIS, diagnosis/ 'HISTAMINE, diagnostic use/ HUMAN/ MALE/ 'OCCUPATIONAL DISEASES, diagnosis/ 'STYRENES, adverse effects/ VINYL COMPOUNDS, advene affects POISONING 4105. [Characteristic* of electrocardiographic changes in patients with chronic vinyl chloride poisoning] Kudriavtseva OF. Gig Tr Prof Zabol 14:54-6, Aug 70 (Rua) ADULT/ AIR POLLUTION/ 'ALKENES, potsonlog/ 'CHLORIDES, poisoning/ 'ELECTROCARDIOGRAPHY/ ENVIRONMENTAL EXPOSURE/ FEMALE/ HUMAN/ MALE/ MIDDLE AGE/ 'OCCUPATIONAL DISEASES, diagnosis/ VINYL COMPOUNDS, poisoning TOXICITY 4108, [Comparative tanitary-toxicologic characteristics of vinylmethyladlpate and divinyladlpate plasticisers and standardisation of their content in water] Mironets NV. Gir Vault 35:88-9. Oct 70 (Rot) 'ADIPIC ACID, toxicity/ 'ALKENES, toxicity/ ANIMAL EXPERIMENTS/ GUINEA PIGS/ MAXIMUM PERMISSIBLE EXPOSURE LEVEL/ MICE/ RABBITS/ RATS/ VINYL COMPOUNDS, toxicity/ 'WATER POLLUTION/ WATER POLLUTION, CHEMICAL VIRAL VACCINES ADVERSE EFFECTS 4107. A method for detecting Newcastle disease virus of low virulence in poultry vaccines. Hirst RG, et at Aust Vet J 47:119-21, Mar 71 ANIMAL EXPERIMENTS/ AUSTRALIA/ CHICK EMBRYO/ HEMAGGLUTINATION INHIBITION TESTS, veterinary/ HEMAGGLUTINATION TESTS, veterinary/ NEWCASTLE DISEASE, Immunology/ 'NEWCASTLE DISEASE VIRUS, isolation A purification/ 'POULTRY DISEASES, Immunology/ 'VIRAL VACCINES, adverse effects/ VIRAL VACCINES, standards/ VIRULENCE 4108. The development of a vaccine against avian lnfectloos laryngotracbeltls. IV. Immunization of chlckeo* with a modified laryngotracheltls vaccine in the Orinkiog water. Sam berg Y. etaL Avian Dls 15:413*7, Apr-Juo 71 ADMINISTRATION. ORAL/ 'CHICKENS/ DNA VIRUSES, Immunology/ EVALUATION STUDIES/ LARYNGITIS, Immunology/ 'LARYNGITIS, veterinary/ 'POULTRY DISEASES, Immunology/ RESPIRATORY TRACT DISEASES, chemically Induced/ OLI 2549 X POLLEN DRUGS AND CHEMICALS POLLEN adverse effects 3287. (Chronic therapy resistant allergy and fitness for military service?] Michel H. et al. Munch Med Wochenscbr 113:160-70, 29 Jar r> ADULT/ ANTIGEN-ANTIBODY RBAC ASTHMA, etiology/ DUST/ GERMAVI HAY FEVER/ HUMAN/ `HYPERSE Si familial A genetic/ HYPERSENSITI T1 occurrence/ MALE/ `MILITARY PEttS' fr NUTS/ POLLEN, adverse effects POLYETHVLENES ADVERSE EFFECTS 3238. Inverted versus everted gastrointestinal anastomoses: the role of the everted mucosa In anastomotic breakdown. Hearn D, et aL Am $urg 38:728-30. Dec 70 ANIMAL EXPERIMENTS/ BACTERIA, growth A development/ BANDAGES, adverse effects/ DOGS/ ILEUM, surgery/ INTESTINAL MUCOSA, microbiology/ `INTESTINAL MUCOSA, phytopathology/ `INTESTINE, SMALL, surgery/ MESENTERY, surgery/. PERITONITIS, etiology/ POLYETHYLENES, adverse effects/ `SURGICAL WOUND DEHISCENCE, etiology/ SURGICAL WOUND DEHISCENCE, physlopathology/ SURGICAL WOUND INFECTION, etiology/ SURGICAL WOUND INFECTION, physlopathology/ SUTURE TECHNICS POLYMERS , ADVERSE EFFECTS 3289. Hemoiytic-uremlc-Uke syndrome following polycarboxylate interferon Induction. Treatment of Dawson's Inclusion-body encephalitis. Leavitt TJ. et al. Am J DU Child 121:43-7, Jan 71 ANEMIA, HEMOLYTIC, chemically Induced/ CHILD/ CHILD, PRESCHOOL/ FEMALE/ HUMAN/ `INTERFERON, adverse effects/ `KIDNEY FAILURE. ACUTE, chemically induced/ MALE/ POLYMERS, adverse effeet*/ PYRANS, adverse effect*/ SUBACUTE SCLEROSING PANENCEPHALITIS, drug therapy/ `THROMBOPENIA, chemically Induced 3290. (Behavior of blood volume, duration of plasms expansion and side effects after parenteral administration of a gelatin polymer (m. w. 35,000)] Allegro G, et al Arch Patol Clin Med 48:259-88, Aug 70 (Its> ADULT/ AGED/ BLOOD COAGULATION, drug effects/ `BLOOD VOLUME/ ELECTROCARDIOGRAPHY/ FEMALE/ GELATIN/ GELATIN, adverse effects/ HUMAN/ INFUSIONS, PARENTERAL/ MALE/ MIDDLE AGE/ `PLASMA SUBSTITUTES/ PLASMA SUBSTITUTES, adverse effects/ POLYMERS/ POLYMERS, adverse effects/ PROTHROMBIN TIME N 3291. [ Complications following reconstructive operations for occlusive sorto-illae lesions] Schneider K, et aL Laagenbsctt* Arch Cblr ,328:50-83, 1970 (Ger) AGE FACTORS/ AGED/ `ANEURYSM, etiology/ ANTICOAGULANTS, therapeutic use/ AORTA, ABDOMINAL, surgery/ ARTERIOSCLEROSIS, surgery/ `BLOOD VESSEL PROSTHESIS, adverse effects/ CHRONIC DISEASE/ `ENDARTERECTOMY, adverse effects/ ENGLISH ABSTRACT/ FEMORAL ARTERY, surgery/ HEMATOMA, etiology/ HUMAN/ "ILIAC ARTERY, surgery/ MIDDLE AGE/ POLYMERS, adverse effects/ POSTOPERATIVE COMPLICATIONS POISONING 3292. [Modern occupational diseases] Lacbnlt V. Wien Med WochensChr 120:820-5, 12 Sep 70 (Ger) AUSTRIA/ BEER, adverse effects/ BONE RESORPTION, chemically induced/ COBALT, poUonlng/ FARMER'S LUNG, chemically Induced/ FARMER'S LUNG, Immunology/ FARMER'S LUNG, occurrence/ FINGERS, pathology/ HEART DISEASES, chemically induced/ HUMAN/ OCCUPATIONAL DISEASES, chemically Induced/ OCCUPATIONAL DISEASES, occurrence/ PLASTICS, poisoning/ POISONING, occurrence/ POLYMERS, poisoning/ POLYVINYLS. poUonlng/ PRECIPITINS, A-244 analysis/ PULMONARY EDEMA, chemically induced/ `TECHNOLOGY TOXICITY 3293, Trends in preparation of new angiographic contrast media with special emphasis on polymeric derivative*. Hilal SK. Invest Radiol 5:458-72. Nov-Dec 70 AMMONIUM COMPOUNDS/ `ANGIOGRAPHY/ ANIMAL EXPERIMENTS/ CALCIUM/ CHEMISTRY/ `CONTRAST MEDIA, cb*m synthesis/ DOGS/ GELATIN/ GUINEA PIGS/ MAGNESIUM/ `POLYMERS/ POLYMERS, metabolism/ POLYMERS, toxicity 3294. Influence of cooking on foodstuffs. Lang K. World Rev Nttr Piet 12:268*317, 1970 (408 ref.) ANIMAL EXPERIMENTS/ ASCORBIC ACID/ BREAD/ CARCINOGENS/ CEREALS/ CHARCOAL/ CHOLESTEROL/ COFFEE/ COOKERY/ DIETARY FATS, metabolism/ DIETARY PROTEINS, metabolUm/ FATS, toxicity/ FISHES/ `FOOD/ HEAT/ HUMAN/ MEAT/ MILK/ MONOSACCHARIDES/ NUCLEIC ACIDS/ NUTRITION/ NUTS/ OLIGOSACCHARIDES/ OXIDATlON*REDUCTlON/ POLYMERS, toxicity/ PROTEIN DENATURATION/ RATS/ REVIEW/ STARCH/ VITAMIN B COMPLEX/ VITAMINS POLYMYXIN ADVERSE EFFECTS 3295. Danger of polymyxin B inhalation. Marschke C, et aL Ann Intern Med 74:298-7, Feb 71 AEROSOLS/ BRONCHIECTASIS, complications/ BRONCHITIS, complications/ `DRUG HYPERSENSITIVITY/ FEMALE/ HUMAN/ MALE/ MIDDLE AGE/ POLYMYXIN, administration k dosage/ `POLYMYXIN, adverse effects/ PSEUDOMONAS AERUGINOSA/ `PSEUDOMONAS INFECTIONS, drug therapy/ `RESPIRATORY INSUFFICIENCY, chemically Induced/ RESPIRATORY TRACT INFECTIONS, drug therapy 3298. Polymyxin Inhalation therapeutic hazard. Marschke G, et aL Ann Intern Med 74:144*5. Jan 71 AEROSOLS, adverse effect*/ FEMALE/ HUMAN/ ISOPROTERENOL, administration k dosage/ MALE/ MIDDLE AGE/ POLYMYXIN, administration It dosage/ `POLYMYXIN, adverse effects/ PSEUDOMONAS INFECTIONS, drug therapy/ `RESPIRATORY INSUFFICIENCY, chemically Induced POLYSACCHARIDES, BACTERIAL TOXICITY 3297. [Toxicity of polyscchartdee from different polysaccharide containing fractions of alkali-forming enterobacteria) Rashba El. et al. Mlkroblol Zb 31:463*7, Sep-Oct 69 (Ukr) ANIMAL EXPERIMENTS/ ENGLISH ABSTRACT/ ENTEROBACTERIACEAE, pathogenicity/ MICE/ `POLYSACCHARIDES, BACTERIAL, toxicity POLYURETHANES TOXICITY 3298. Chemical structure of polyurethane foam. Woolrlch PF. J Occup Med 12:529, Dec 70 CHEMISTRY/ HUMAN/ `INDUSTRIAL MEDICINE/ NOMENCLATURE/ POLYURETHANES, toxicity/ `URETHANE, toxicity POLYVINYLPYRROLIDONE ADVERSE EFFECTS 3299. [Ultrastructure stydy of skin Infiltration by polyvinylpyrrolidone (subatosan)) Leung TK, et il Ann Dermatol SyphlUgr (Paris) 97:567-72, 1970 (Fre) BIOPSY/ FEMALE/ HUMAN/ LYSOSOMES/ MALE/ MICROSCOPY. ELECTRON/ MIDDLE AGE/ `POLYVINYLPYRROLIDONE, adverse effects/ POLYVINYLPYRROLIDONE, pharmacodynamics/ `SKIN, drug effects/ SKIN, pathology/ SKIN DISEASES, chemically Induced/ `SKIN DISEASES, pathology 3300. Ultrastructural morphology jdstoebemlstry (add OLI 2550 DRUGS AND CHEMICALS 31- POTASSIUM phosphatase) of the cutaneous infiltration by polyvinylpyrrolidone. Thlvolet J, et *1. Br J Dermatol 83:661-9, Dec 70 ACID PHOSPHATASE, analysts/ BIOPSY/ female/ FIBROBLASTS/ FIBROMA, enzymoloey/ `FIBROMA, pathology/ GRANULOMA, pathology/ HISTIOCYTES/ HISTOCYTOCIIEMISTRY/ HUMAN/ LYSOSOMES. enzymology/ MALE/ MICROSCOPY. ELECTRON/ MIDDLE AGE/ POLYVINYLPYRROLIDONE, adverse effects/ POLYVINYLPYRROLIDONE, metabolism/ SKIN, drug effects/ SKIN, metabolism/ SKIN, pathology/ `SKIN DISEASES, chemically Induced POLYVINYLS ADVERSE EFFECTS 3301. Occupational acroosteolysls. II, An Industrial hygiene study. Cook WA, et al. Arch Environ Health 22:74-62, Jan 71 BONE RESORPTION, chemically induced/ BONE RESORPTION, etiology/ BONE RESORPTION, occurrence/ BONE RESORPTION, prevention & control/ CHLORIDES, adverse effects/ ENVIRONMENTAL EXPOSURE/ FEMALE/ HAND/ `HEALTH SURVEYS/ HUMAN/ INDUSTRIAL MEDICINE/ MALE/ OCCUPATIONAL DISEASES, chemically Induced/ OCCUPATIONAL DISEASES, etiology/ OCCUPATIONAL DISEASES, occurrence/ OCCUPATIONAL DISEASES, prevention ft control/ `POLYVINYLS, adverse effects/ STATISTICS 2302. Occupational acroosteolysls. 1. An epidemiological study. Dinman BD, et al. _. Arch Environ Health 22:61-73, Jan 71 ADULT/ `ALKENES, adverse effects/ BONE RESORPTION, chemically Induced/ BONE RESORPTION, etiology/ `BONE RESORPTION, occurrence/ BONE RESORPTION, prevention ft control/ `CHLORIDES, adverse effects/ FEMALE/ HAND/ HAND, radiography/ HEALTH SURVEYS/ HUMAN/ INDUSTRIAL MEDICINE/ MALE/ MIDDLE AGE/ OCCUPATIONAL DISEASES, chemically Induced/ OCCUPATIONAL DISEASES, etiology/ 'OCCUPATIONAL DISEASES, occurrence/ OCCUPATIONAL DISEASES, prevention A control/ `POLYVINYLS, adverse effects/ POPULATION SURVEILLANCE/ QUESTIONNAIRE/ RAYNAUD'S DISEASE, complications/ STATISTICS 3303. Occupational acroosteolysls. 3. A clinical study. Dodson VN. at al. Arch Environ Health 22:83-91, Jan 71 ADULT/ `BONE RESORPTION, diagnosis/ BONE RESORPTION, prevention ft control/ BONE RESORPTION, radiography/ CALCIUM, analysis/ CATECHOLAMINES, urine/ CHLORIDES, adverse effects/ FECES, analysis/ FLUORINE, diagnostic use/ HAND, radiography/ HUMAN/ HYDROXYINDOLEACET1C ACID, urine/ INDUSTRIAL MEDICINE/ MALE/ MIDDLE AGE/ `OCCUPATIONAL DISEASES, diagnosis/ PHOSPHORUS, analysis/ PLETHYSMOGRAPHY/ `POLYVINYLS, adverse effect#/ RADIOISOTOPE SCANNING/ RAYNAUD'S DISEASE, complications/ RAYNAUD'S DISEASE, diagnosis 3304. [Pneumoconiosis caused by inhalation of polyvinylchloride] Stende B, et aL Orv HetU 112:83*6, 10 Jan 71 (Hnn) ADULT/ 'CHLORIDES, adverse effects/ DUST/ ENVIRONMENTAL EXPOSURE/ HUMAN/ MALE/ `PNEUMOCONIOSIS, etiology/ `POLYVINYLS, adverse effects POISONING 3303. Pneumoconiosis caused by tbe Inhalation of polyvinylchloride dust. Stende B, et al. Med Lav 31:433-6, AugSep 70 ADULT/ AIR POLLUTION/ ENVIRONMENTAL EXPOSURE/ HUMAN/ MALE/ PNEUMOCONIOSIS, etiology/ `POLYVINYLS, poisoning 3308. [Modern occupational diseases) Lachnlt V. Wien Med Wochenschr 120:620-5, 12 Sep 70 (Gr) AUSTRIA/ BEER, adverse effects/ BONE RESORPTION, chemically induced/ COBALT, poisoning/ FARMER'S LUNG, chemically Induced/ FARMER'S LUNG, Immunology/ FARMER'S LUNG, occurrence/ FINGERS, pathology/ HEART DISEASES, chemically Induced/ HUMAN/ OCCUPATIONAL DISEASES, chemically induced/ OCCUPATIONAL DISEASES, occurrence/ PLASTICS, poisoning/ POISONING, occurrence/ POLYMERS, poisoning/ POLYVINYLS, poisoning/ PRECIPITINS, analysis/ PULMONARY EDEMA, chemically induced/ `TECHNOLOGY TOXICITY 3307. Polyfvinylpyrldlne oxides) In pneumoconiosis research. Holt PF. Br J tad Med 38:73*7, Jan 71 (41 ref.) AEROSOLS/ ANIMAL EXPERIMENTS/ CELL MEMBRANE/ `CYCLIC N-OXIDES, administration & dosage/ CYCLIC N-OXIDES, toxicity/ HUMAN/ INJECTIONS, INTRAPERITONEAL/ INJECTIONS, INTRAVENOUS/ INJECTIONS. SUBCUTANEOUS/ MACROPHAGES, drug effects/ MOLECULAR WEIGHT/ PERITONEUM, eytoiogy/ `PNEUMOCONIOSIS, drug therapy/ POLYSTYRENES, therapeutic use/ `POLYVINYLS, administration ft dosage/ POLYVINYLS, toxicity/ PULMONARY ALVEOLI, cytology/ PULMONARY FIBROSIS, drug therapy/ `PYRIDINES, administration ft dosage' PYRIDINES, toxicity/ RATS/ REVIEW/ SILICA/ TISSUE CULTURE 3308. (Carboxyvlnylpolymers in pharmaceutical technic. II] Ferotti AG. Fermace [Prat] 25:721*43, Dec 70 (Ita) ELECTROENCEPHALOGRAPHY/ EMULSIONS/ GELS/ HYDROGEN-ION CONCENTRATION/ IRRITANTS/ LUBRICATION/ OINTMENTS/ POLYVINYLS/ POLYVINYLS, toxicity/ SKIN TESTS/ SOLUBILITY/ SUSPENSIONS/ TABLETS/ TECHNOLOGY, PHARMACEUTICAL POTASSIUM ADVERSE EFFECTS 3309. Occupational dermatltla in five European dermatological department#. Melten KE, et aL Berultdertaatosen 19:1*14, Feb 71 BALSAMS, adverse effect#/ BENZOCAINZ, adverse effect#/ CHROMATES, adverse effects/ CLINICAL RESEARCH/ COBALT, advert* effect#/ EUROPE/ FEMALE/ HAND DERMATOSES, occurrence/ HUMAN/ MALE/ NEOMYCIN, adverse effects/ NICKEL, adverse effect#/ OCCUPATIONAL DERMATITIS, diagnosis/ 'OCCUPATIONAL DERMATITIS, occurrence/ POTASSIUM, adverse effects/ PROSPECTIVE STUDIES/ RUBBER, adverse effects/ SKIN TESTS/ TARS, adverse effects 3310. [Experimental bases for tbe use of acetylcholine in tbe treatment of arrhythmias earned by potaaaium] Ralnerl A, et mL Bell 8oc It*! Cardiol 10:77*90, 1988 (Ita) ACETYLCHOLINE, pharmacodynamics/ ACETYLCHOLINE, pharmacodynamics/ ANIMAL EXPERIMENTS/ ARRHYTHMIA, chemically induced/ `ARRHYTHMIA, chemically Induced/ DOGS/ ELECTROCARDIOGRAPHY/ ENGLISH ABSTRACT/ POTASSIUM, adverse affects/ POTASSIUM, advene effect# 3311. Toxic psychosis induced by Asthma-Dor, Hussain MZ. Can Mad Assoc J 104:326, 20 Feb 71 ADOLESCENCE/ ASTHMA, drug therapy/ DRUG ABUSE/ HUMAN/ MALE/ NITRATES, adverse effects/ PLANT EXTRACTS, adverse effects/ POTASSIUM, adverse effects/ PSYCHOSES, TOXIC/ STRAMONIUM, adverse effects 3312. [On skin morbidity caused by cement In construction workers and cement worken] Petruzzellla V, et *L G Ital Dermatol 44:485-7. Sep 69 (It*) *CHROMATES, adverse effect#/ `DERMATITIS, CONTACT, chemically Induced/ HUMAN/ `OCCUPATIONAL DERMATITIS, chemically Induced/ POTASSIUM, adverse effects 3313. Patch testing with potassium dlchromate In different vehicles. Skog E, et al. G Ital Dermatol 44:467-9, Sp 69 CHROMATES, adverse effects/ `DERMATITIS, CONTACT/ POTASSIUM, adverse effects/ SKIN TESTS/ `VEHICLES, pharmacodynamics 3314. Electron microscope observations on form changes In A-24S OLI 2551 4 4 I j ,5 .'.'j 3 ') 3 j I I 1 i f * l POLYMYXIN DRUGS AND CHEMICALS i INFANT, NEWBORN/ KIDNEY, drug effects/ KIDNEY DISEASES, chemically Induced/ NEUROMUSCULAR DISEASES, chemically Induced/ POLYMYXIN, administration A dotage/ POLYMYXIN, adverse effects/ POLYMYXIN, metabolism/ POLYMYXIN, pharmacodynamics/ *POLYMYXIN, therapeutic use/ *PSEUDOMONAS INFECTIONS, drug therapy/ REVIEW/ SULFATES/ `URINARY TRACT INFECTIONS, dm* therapy POLYNUCLEOTIDES TOXICITY 3514. Pharmacology of polyrlboinosinic; polyrlbocytidyUc acid, a new antiviral and antitumor agent. Adamson RH* etal. AntlmlerobAreotsCbemother 9:148-52,1969 ANIMAL EXPERIMENTS/ `ANTINEOPLASTIC AGENTS, therapeutic use/ `ANTIVIRAL AGENTS, pharmacodynamics/ CYTOSINE/ EMBRYO, drug effects/ MICE/ MONKEYS/ `NEOPLASMS, EXPERIMENTAL drug therapy/ POLYNUCLEOTIDES, chem synthesis/ `POLYNUCLEOTIDES, therapeutic use/ POLYNUCLEOTIDES, toxicity/ . PREGNANCY/ RABBITS/ RATS/ RNA* ebem synthesis/ RNA, phannaeodynamics/ RNA, therapeutic use/ RNA, toxicity 3315. Toxicity of poly 1; poly C for rabbit eyes. Ostler HR, et aL Nature (Londl 228:363-4, 24 Oct 70 ANIMAL EXPERIMENTS/ AQUEOUS HUMOR, drug effects/ `CATARACT, chemically induced/ `CYTOSINE NUCLEOTIDES, toxicity/ DISEASE MODELS, ANIMAL/ HERPESVIRUS INFECTIONS, drug therapy/ INTERFERON, biosynthesis/ KERATOCONJUNCTIVITIS, drug therapy/ `LENS, CRYSTALLINE, drug effect*/ POLYNUCLEOTIDES, therapeutic use/ `POLYNUCLEOTIDES, toxicity/ RABBITS 3316. Morphological changes In chick cerebellum Induced by poly I-poly C. Young PA, et al. Nature (Load) 2X8:1191-2. 19 Dec 70 ANIMAL EXPERIMENTS/ `ANTIVIRAL AGENTS, toxicity/ CAPILLARY FRAGILITY, drug effects/ `CEREBELLAR ATAXIA, chemically induced/, CEREBELLUM, blood supply/ CEREBELLUM, drug effects/ CHICKENS/ INTERFERON, biosynthesis/ MICROSCOPY, ELECTRON/ `POLYNUCLEOTIDES, toxicity POLYSACCHARIDES TOXICITY 3517. Fractionation mnd purification of tho polynocebnrldon with marked antitumor activity, eapeetally lentlnan, from Leatlnni adodoa (Bark.) Sin,, (an adlbln muahroom). Chilian G, ot al. Cancer Hea 30:3778^11, Nov 70 ANIMAL EXPERIMENTS/ CHROMATOGRAPHY, OEAE47ELLULOSE/ ELECTROPHORESIS/ HYDROGEN-ION CONCENTRATION/ MICE/ `MUSHROOMS/ OPTICAL ROTATORY DISPERSION/ POLYSACCHARIDES, laoMUon A purification/ POLYSACCHARIDES, tAarapeutle us,/ POLYSACCHARIDES, toxlelty/ `SARCOMA ISO, CROCKER, drus therapy/ TISSUE EXTRACTS/ ULTRACENTRIFUGATION POLYSACCHARIDES, BACTERIAL ADVERSE EFFECTS 3518. Metabolic and thermal responses to Plromen in man. Davidson MB, et al. J CU Endocrinol Metab 32:179*87, Feb 71 ADULT/ `BLOOD SUGAR/ BODY TEMPERATURE, drug effects/ CLINICAL RESEARCH/ `FATTY ACIDS, NONESTERIFIED, blood/ GLUCOSE, pharmacodynamics/ `GLYCERIN, blood/ . HEADACHE, chemically Induced/ HUMAN/ `INSULIN, blood/ LIPIDS, metabolism/ MALE/ POLYSACCHARIDES, BACTERIAL, adverse effect*/ `POLYSACCHARIDES, BACTERIAL, pharmacodynamics/ PSEUDOMONAS/ RESERPINE, pharmacodynamics/ SHIVERING/ SOMATOTROPIN, blood/ SOMATOTROPIN, secretion 3519. (AntMuroor activity and side reaction of bacterial component) Umezawa 1. Jap J Antiblot 23:287-97, Jun 70 (Jap) ANIMAL EXPERIMENTS/ ANTIBIOTICS, A-252 ^ #/ ANTINEOPLASTIC, therapeutic use/ BODY TEMPERATURE, drug effects/ CARCINOMA. EHRLICH TUMOR, drug therapy/ ESCHERICHIA COLI. analysis/ LEUKOCYTE COUNT/ LEUKOCYTES, drug effects/ LtPOPOLYSACCHARlDES, adverse effects/ LIPOPOLYSACCHARIDES, therapeutic use/ MICE/ `POLYSACCHARIDES, BACTERIAL, adverse effects/ `POLYSACCHARIDES. BACTERIAL, therapeutic use/ `PSEUDOMONAS AERUGINOSA, analysis/ RABBITS/ RETICULOENDOTHELIAL SYSTEM, drug effects/ `SARCOMA 180, CROCKER, drug therepy/ `STAPHYLOCOCCUS, analysis/ `STREPTOCOCCUS PYOGENES, analysis POLYSTYRENES ADVERSE EFFECTS 3320. An evaluation of polyelectrolyte complexes as biomedical materials. Marshall DW, et al. J Blomed Mater Res 4:357-88, Sep 70 ANIMAL EXPERIMENTS/ BIODEGRADATION/ BIOMECHANICS/ EQUIPMENT AND SUPPLIES/ `MEMBRANES, ARTIFICIAL/ `POLYMERS, adverse effects/ POLYSTYRENES, adverse effects/ POLYVINYLS, adverse effects/ `PROSTHESIS, standards/ RABBITS/ RATS/ STERILIZATION/ THROMBOSIS, chemically Induced POLYTHIAZIDE ADVERSE EFFECTS 35X1, Praioelfi hydrochloride (CP-12^99-1), an oral antl-hypertenslve agent: preliminary clinical observations lo ambulatory patients. Cohen RM. J Clin Pharmacol 10:408-17, Nov-Dee 70 ADOLESCENCE/ ADULT/ AGED/ AMBULATORY CARE/ ANTIHYPEKTENSIVE AGENTS, adverse effects/ ANTIHYPERTBNSIVX AGENTS, therapeutic use/ BLOOD PRESSURE, drug effects/ - CLINICAL RESEARCH/ COMPARATIVE STUDY/ ELECTROCARDIOGRAPHY/ FEMALE/ HUMAN/ HYPERTENSION, blood/ MALE/ MIDDLE AGE/ PIPERAZINES, adverse effects/ `PIPERAZINES, therapeutic use/ PLACEBOS/ POLYTHIAZIDE, adverse effects/ POLYTHlAZIDE, therapeutic use/ QUINAZQUNES, adverse effects/ QUINAZOLINES, therapeutic use POLYURETHANES ADVERSE EFFECTS 33X3. [Use of polyurethanes In the building tndusty. Pathological axards and their prevention] Jullieo G, et el Arch Mai Prof 31:44-6, Jao-Feb 70 (Fre) ENVIRONMENTAL EXPOSURE/ FRANCE/ HUMAN/ INSURANCE. HEALTH/ LEGISLATION/ `OCCUPATIONAL DISEASES, chemically Induced/ OCCUPATIONAL DISEASES, prevention fc control/ `POLYURETHANES, adverse effects/ SKIN MANIFESTATIONS POLYVINYLPYRROLIDONE ADVERSE EFFECTS 3533. [Thesaurismosis due to polyvinyl pyrtolidooe resembling inflammatory tumor of the big epiploon) Coulnnud C, ot al. Fresse Med 78:1839-41. 10 Oct 70 (Fre> ADULT/ DIAGNOSIS, DIFFERENTIAL/ FEMALE/ `GRANULOMA, chemically induced/ GRANULOMA, pathology/ HUMAN/ MALE/ METABOLIC DISEASES/ MIDDLE AGE/ `OMENTUM, pathology/ OMENTUM, surgery/ PERITONEAL DISEASES, chemically induced/ PERITONEAL DISEASES, pathology/ PERITONEAL DISEASES, surgery/ PERITONEAL NEOPLASMS, diagnosis/ POLYVINYLPYRROLIDONE, adverse effect* POLYVINYLS ADVERSE EFFECTS 3524. [Hamrds to the skin In the plastics industry] Weichardt H. Berufsdermatosen 18:25-34, Feb 70 (Cer) ACNE, chemically Induced/ ACRYLIC RESINS, adverse effects/ ALANINE AMINOTRANSFERASE, blood/ ASPARTATE AMINOTRANSFERASE, blood/ BILIRUBIN, blood/ BONE RESORPTION, etiology/ A OLl 2552 DRUGS AND CHEMICALS PREDNISOLONE DERMATITIS, CONTACT, etiology/ ECZEMA, etiology. ENGLISH ABSTRACT/ FINGERS, injuries/ HEPATITIS, TOXIC, etiology/ HUMAN/ NAPHTHALENES, adverse effects/ `OCCUPATIONAL DERMATITIS, chemically Induced/ `PLASTICS, adverse effects/ POLYMERS, adverse effects/ POLYVINYLS, adverse effects/ PRURITUS, chemically induced/ RAYNAUD'S DISEASE, chemically induced/ RESINS, adverse effects/ *SK1N DISEASES, chemically Induced/ SKIN TESTS 3525 An evaluation of polyelectrolyte complexes aa biomedical materials. Marshall DW, et al. J (Homed Mater Res 4:357-68, Sep 70 ANIMAL EXPERIMENTS/ BIODEGRADATION/ BIOMECHANICS/ EQUIPMENT AND SUPPLIES/ `MEMBRANES. ARTIFICIAL/ POLYMERS, adverse effects/ POLYSTYRENES, adverse effects/ POLYVINYLS, adverse effects/ PROSTHESIS, standards/ RABBITS/ RATS/ STERILIZATION/ THROMBOSIS, chemically Induced POTASSIUM ADVERSE EFFECTS 3526 Reversion of atrial fibrillation following hyperkalemia. Manchester JH, et al. Chest 58:399-402, Oct 70 ACUTE DISEASE/ ARRHYTHMIA, SINUS, cnemtcally induced/ `AURICULAR FIBRILLATION, complications/ AURICULAR FIBRILLATION, therapy/ ELECTROCARDIOGRAPHY/ GLUCOSE, therapeutic use/ HEART ATRIUM, physiopatbology/ HEART CONDUCTION SYSTEM, physiopatbology/ HUMAN/ HYPERKALEMIA, complications/ HYPERKALEMIA, therapy/ INSULIN, therapeutic use/ MIDDLE AGE/ PACEMAKER, ARTIFICIAL/ POTASSIUM, adverse effects/ POTASSIUM, therapeutic use/ SODIUM, therapeutic use 3527. Potassium therapy and gastrointestinal lesions. Emerson DN. Nebr State Med l 55:518-23, Sep 70 ANIMAL EXPERIMENTS/ DIURETICS, therapeutic use/ DRUG AND NARCOTIC CONTROL/ HUMAN/ 'INTESTINAL DISEASES, chemically Induced/ `INTESTINAL OBSTRUCTION, chemically induced/ INTESTINE, SMALL, drug effects/ POTASSIUM, adverse effects/ POTASSIUM CHLORIDE, adverse effects/ ULCER, chemically Induced POISONING 3528. [A fatal case of potassium chlorate poisoning) Fukumoto K, et al. Jap J Leg Med 24:242-6, May 70 (Jap) AGED/ AUTOPSY/ 'CATHARTICS, poisoning/ ENGLISH ABSTRACT/ FEMALE/ HUMAN/ `PERCHLORIC ACIDS, poisoning/ POISONING, pathology/ `POTASSIUM, poisoning TOXICITY 3529. Potassium and arrhythmias. Davis RH, et al. Geriatrics 25:108-16, Nov 70 ADMINISTRATION, ORAL/ * ARRHYTHMIA, drug therapy/ ELECTROCARDIOGRAPHY/ HEART BLOCK/ HEART CONDUCTION SYSTEM, drug effects/ HUMAN/ HYPERKALEMIA/ INJECTIONS, INTRAVENOUS/ KIDNEY FAILURE, ACUTE/ PACEMAKER, ARTIFICIAL/ 'POTASSIUM, administration & dosage/ POTASSIUM, toxicity POTASSIUM CHLORIDE ADVERSE EFFECTS 3530. [Gastric perforation due to potassium chloride pills] Aoustln J, et ah Ct&irurgie 96:172-3, 1970 (Fre] ADMINISTRATION. ORAL/ AGED/ HUMAN/ MALE/ POTASSIUM CHLORIDE, administration 8c dosage/ `POTASSIUM CHLORIDE, adverse effects/ `STOMACH RUPTURE, chemically Induced 3531. (Steoosisand Intestinal perforation after absorption of potassium chloride] Cblche P, et ah Coeur Med Interne 8.403-7, Jul 69 (Fre) `HEART DISEASES, drug therapy/ HUMAN/ INTESTINAL OBSTRUCTION, chemically induced/ `INTESTINAL PERFORATION, chemically induced/ MALE/ MIDDLE AGE/ PEPTIC ULCER PERFORATION, chemically Induced/ `POTASSIUM CHLORIDE, adverse effects 3532. Potassium therapy and gastrointestinal lesions. Emerson DN. Nebr State Med J 55:518-23, Sep 70 ANIMAL EXPERIMENTS/ DIURETICS, therapeutic use/ DRUG AND NARCOTIC CONTROL/ HUMAN/ `INTESTINAL DISEASES, chemically Induced/ `INTESTINAL OBSTRUCTION, chemically induced/ `INTESTINE, SMALL, drug effects/ `POTASSIUM, adverse effects/ POTASSIUM CHLORIDE, adverse effects/ ULCER, chemically induced POTASSIUM PERMANGANATE adverse effects 3533. [Vaginal burns by caustic substances. A socio-medical problem] Zirate Sandoval H, et al. Glnecol Obstet Mex 27:559*67, May 70 (Spa] ABORTION, CRIMINAL/ ADOLESCENCE/ ADULT/ `BURNS, CHEMICAL/ `CAUSTICS, adverse effects/ ENGLISH ABSTRACT/ FEMALE/ HUMAN/ `POTASSIUM PERMANGANATE, adverse effects/ pregnancy/ pregnancy COMPLICATIONS, chemically Induced/ SOCIOECONOMIC FACTORS/ `VAGINAL DISEASES, chemically Induced POISONING 3534. [Attempt at abortion with potassium permanganate tablets] Le Coz A, et al. Bull Fed Soc Gynecol Obstet Lang Fr 20:190-1, Apr-May 68 (Fre] `ABORTION. CRIMINAL/ FEMALE/ HUMAN/ `POTASSIUM PERMANGANATE, poisoning/ PREGNANCY/ TABLETS PRALIDOXIME COMPOUNDS TOXICITY 3535. Resistance to various pesticides Induced by catatoxic steroids. Selye H, Arch Environ Health 21:708-10, Dec 70 ADMINISTRATION, ORAL/ ANABOLIC STEROIDS, pharmacodynamics/ ANIMAL EXPERIMENTS/ DDT. toxicity/ DESOXYCORTICOSTERONE, pharmacodynamics/ ESTRADIOL, pharmacodynamics/ ETHYLESTRENOL, pharmacodynamics/ FEMALE/ INSECTICIDES, antagonists A inhibitors/ `INSECTICIDES, toxicity/ OXANDROLONE, pharmacodynamics/ PARATHION, toxicity/ PHOSPHORIC ACIDS, antagonists A inhibitors/ `PHOSPHORIC ACIDS, toxicity/ PHYSOSTIGMINE, toxicity/ PRALIDOXIME COMPOUNDS, toxicity/ PREDNISOLONE, pharmacodynamics/ PREGNANEDIOL, pharmacodynamics/ PREGNANES, pharmacodynamics/ PROGESTERONE, pharmacodynamics/ RATS/ SPIRONOLACTONE, pharmacodynamics/ `STEROIDS, pharmacodynamics/ THYROXINE, pharmacodynamics/ TRIAMCINOLONE, pharmacodynamics 3536. [Hepatotoxicity of nitrostigmlne (E 605 forte) and obidoxlme (Toxogonln) in dogs] Boelcke G, et al. Arch Toxlko! 26.93-101, 1970 <Ger] ALANINE AMINOTRANSFERASE, blood/ ANIMAL EXPERIMENTS/ ANTIDOTES/ ASPARTATE AMINOTRANSFERASE, blood/ ATROPINE, therapeutic use/ CHOLINESTERASE, blood/ DOGS/ ENGLISH ABSTRACT/ ERYTHROCYTES, eiwyraology/ FEMALE/ LACTATE DEHYDROGENASE, blood/ `LIVER, drug effects/ MALE/ PARATHION, toxicity/ `PRALIDOXIME COMPOUNDS, toxicity/ SUCCINA DEHYDROGENASE, blood OLI 2553 PREDNISOLONE ADVERSE EFFECTS 3537. Vasculas complication, in nephrotic syndrome. relationship to steroid therapy and accelerated thromboplastin generation. Mukherjee AP. et al. Br Med 1 4:2734, 31 Oct 70 ADULT/ BLOOD CELL COUNT/ BLOOD COAGULATION TESTS/ BLOOD PLATELETS/ CHOLESTEHOL. blood/ FEMALE/ HEPARIN, therapeutic `use/ HUMAN/ MALE/ , ^ NEPHROTIC SYNDROME, complications/ A.253 I 1 i < POLYSTYRENES DRUGS AND CHEMICALS POLYSTYRENES GASTROINTESTINAL DISEASES, etiology/ HUMAN/ MALE/ OCCUPATIONAL TOXICITY DISEASES, chemically induced/ POLYVINYLS, adverse effects/ `STYRENES, 3001. [Data on hygienic touts of some polymer materIlls used adverse effects In house construction] SUnicevlch KI et aL \ Vrach Delo 5:105*9, May 60 (Itus) i ANIMAL EXPERIMENTS/ ENGLISH POISONING ABSTRACT/ ENVIRONMENTAL EXPOSURE/ t HOUSING/ HUMAN/ MAXIMUM yPERMISSIBLE EXPOSURE LEVEL/ 3008, ["Polyneuritis cranlalls" following poisoning with chlorinated acetylenes in connection with vtuylideoe copolymers] Henschler D, et aL POLYMERS, toxicity/ `POLYSTYRENES, Arch Toxlk 26:62*75, 1970 (Ger) toxicity ACETYLENE, poisoning/ ADULT/ POLYTHIAZIDE ALKYNES, poisoning/ `CRANIAL NERVES, pathology/ ENGLISH ABSTRACT/ ADVERSE EFFECTS ENVIRONMENTAL EXPOSURE/ HUMAN/ HYDROCARBONS. HALOGENATED, poisoning/ HYPOGLOSSAL NERVE, drug 5002. (Hyperparathyroidism caused by thiazides] effects/ MALE/ MASTICATORY MUSCLES, Deutsch Med Wschr 95:244, 30 Jan 70 (G*r) drug effects/ MIDDLE AGE/ OCULOMOTOR ANTIHYPERTENSIVE AGENTS, adverse MUSCLES, drug effects/ `POLYNEURITIS, effects/ CHLOROTHIAZIDE, adverse effects/ chemically induced/ `POLYVINYLS, poisoning/ HUMAN/ HYDROCHLOROTHIAZIDE, adverse TRIGEMINAL NERVE, drug effects/ effects/ `HYPERPARATHYROIDISM, chemically Induced/ HYPERTENSION, TRIGEMINAL NERVE, pathology complications/ HYPERTENSION, drug therapy/ PORPHYRINS POLYTHIAZIDE, adverse effects/ TU$E FACTORS ADVERSE EFFECTS POLYURETHANES TOXICITY 3003. Hemolysis associated with plastics-a histopathologic study with polyurethane. Rlgdon RH. J BJomed Mat Res 4:57-71, Mar 70 ANIMAL EXPERIMENTS/ CARBON/ CREATINE, metabolism/ `ERYTHROCYTES, drug effects/ FLUOROCARBON POLYMERS/ GLASS/ GRANULOMA, chemically Induced/ HEMOLYSIS/ HEMOSIDERIN, metabolism/ MICE/ NYLON/ `POLYURETHANES, toxicity/ RATS/ RESINS 3009, [Significance of ly&osomes for cutaneous photosensttUatlon by porphyrins and other sensitizers] Magnus IA. Arch Klin Exp Derm 237:484*6, 1970 (Ger) ACID PHOSPHATASE, analysis/ ANIMAL EXPERIMENTS/ BENZENE HEXACHLORlDE/ HUMAN/ `LYSOSOMES, enzymology/ LYSOSOMES, radiation effects/ PHOTOSENSITIZATION, chemically Induced/ PHOTOSENSITIZATION, enzymology/ PHOTOSENSITIZATION, etiology/ PORPHYRIA, complications/ `PORPHYRINS, adverse effects/ RADIATION EFFECTS/ SELF MEDICATION/ THIOCAKBAMATES POLYVINYLPYRROLIDONE POTASSIUM adverse effects ADVERSE EFFECTS 3004. (Polyvinyl disease] Cabanne F, et aL 3010. [Pain producing subetences) Keel* CA. Ana Anat Path (Paris) 14:419*39, Oct-Dec 69 (Fre) BJppokrates 40:777*82, 31 Oct 69 (Ger) ADULT/ ANIMAL EXPERIMENTS/ BONE CHEMORECEPTORS, drug effect#/ DISEASES, chemically Induced/ CAPILLARIES, EXTRACELLULAR SPACE/ HISTAMINE, pathology/ ENGLISH ABSTRACT/ FEMALE/ adverse effects/ HUMAN/ KININS. adverse GUINEA PIGS/ HEPATOMEGALY, chemically effects/ `PAIN, chemically induced/ PAIN, Induced/ HISTIOCYTES, enaymology/ HUMAN/ etiology/ POTASSIUM, adverae effects/ INFLAMMATION, chemically Induced/ JOINT SEROTONIN, adverse effects DISEASES, chemically Induced/ LUNG DISEASES, chemically Induced/ LYMPH 3011. Increase In thyrotoxicosis In endemic goitre aree after NODES, pathology/ MALE/ MIDDLE AGE/ lodatlon of bread. Connolly RJ, et aL MUSCULAR DISEASES, chemically Induced/ Lancet 1:500*2, 7 Mar 70 `POLYVINYLPYRROLIDONE, adverse effects/ ADOLESCENCE/ ADULT/ AGE FACTORS/ POLYVINYLPYRROLIDONE, analysis/ SKIN AGED/ AUSTRALIA/ `BREAD/ CHILD/ DISEASES, chemically Induced/ GOITER, complications/ `GOITER, prevention SPLENOMEGALY, chemically induced & control/ GOITER, ENDEMIC, prevention A POLYVINYLS control/ HUMAN/ HYDROXIDES, administration A dosage/ `HYDROXIDES, -* ADVERSE EFFECTS ; adverse effects/ `HYPERTHYROIDISM, chemically Induced/ HYPERTHYROIDISM, occurrence/ IODIDES, 3005. Prolonged endotracheal intubation or tracheostomy in administration A dosage/ `IODIDES, adverse infants and children. Mattlla MA, et aL effects/ MIDDLE AGE/ POTASSIUM, adverse i 4 Fedlat Surg 4:674*82, Dee 69 CHILD/ CHILD, PRESCHOOL/ COMPARATIVE effects l STUDY/ FINLAND/ HUMAN/ INFANT/ INFANT, NEWBORN/ `INTUBATION, 3012. [Chemical mediators of pain] Musto P, et al. Minerva Ansst 35:1165-71, Nov 69 (Ita) INTRATRACHEAL/ INTUBATION. `ACETYLCHOLINE, adverse effects/ `AMIDES, INTRATRACHEAL, adverse effects/ adverse effects/ `CATECHOLAMINES, adverse INTUBATION, INTRATRACHEAL, effects/ ENGLISH ABSTRACT/ `HISTAMINE, instrumentation/ LARYNX. Injuries/ adverse effects/ HUMAN/ `KININS, adverse POLYVINYLS, adverse effects/ RUBBER, effects/ `PAIN, chemically induced/ PAIN, adverse effects/ TIME FACTORS/ TRACHEAL etiology/ `POTASSIUM, adverse effects/ STENOSIS, etiology/ `TRACHEOTOMY SEROTONIN, adverse effects 3006. [Development of arachnoendothellal accumulations in POISONING i. the dura mater following alloplasty of Its defects under experimental conditions] Maiorova NA, et al. 9013. Acute potassium dlchrornate poisoning- Treated by i Vop Ncirokhir 33:50-3, Jul-Aug 69 (Rns> ANIMAL EXPERIMENTS/ `ARACHNOID, peritoneal dialysis. Kaufman DB, et aL Amer J DIs Child 119:374*6, Apr 70 pathology/ DOGS/ DURA MATER, pathology/ ACUTE DISEASE/ ADOLESCENCE/ DURA MATER, Surgery/ FEMALE/ MALE/ ASCORBIC ACID, therapeutic use/ AUTOPSY/ i POLYVINYLS, adverse effects/ `SURGERY, BRAIN CHEMISTRY/ `CHROMATES, OPERATIVE, adverse effects poisoning/ CHROMIUM, blood/ DIMERCAPROL, therapeutic use/ HUMAN/ 3007. [Effect of petroleum hydrocarbons on the condition of KIDNEY, pathology/ LIVER, pathology/ the cardiovascular system In diseases of the MALE/ `PERITONEAL DIALYSIS/ gastrointestinal tract] Bashirov AA_ POISONING, drug therapy/ `POISONING, Vrach Delo 11:55-9, Nov 67 (Rus) therapy/ `POTASSIUM, poisoning ADULT/ `CARDIOVASCULAR DISEASES, etiology/ ENGLISH. ABSTRACT/ 3014. [Transfusion reactions] Bube FW. ENVIRONMENTAL EXPOSURE/ FEMALE/ Internist (Berlin) 10:46*51, Feb 69 (Ger) A.214 OLI 2554 3 3 &-JL 1/ JiA 790139496R V0L=79 ISS=24 SEC=59 WT*11 CA447CARD 30 7/' HYGIENIC EVALUATION OF WORKING CONDITIONS IN SOME CHEMICAL ( PLANTS OPERATING IN THE OPEN AIR FILATOVA, V. S. / VINOGRADOVA, V. K. BASHKIROVA, L. S. C INST. GIG. TR. PROFZABOL. / GORKI / USSR GIG. TR. PROF. ZABOL. GTPZAB, VOL ,ISS 8 , f //KEYWORDS// AMMONIA PRODN HYGIENE YR 1973, PGS 8 -11 VINYL CHLORIDE PRODN HYGIENE C ACS COPYRIGHT 1973,CA-CONDENSATES } ") -) 3 3 C3 3/, 7900231 ti5J VOL= 79 ISS= 04 WT= II CA447CARD 59 X7 HYGIENIC CbUIFICATION OF THE BUILDING PROJECTS, OEVELOPMEN T, AND RECONSTRUCTION OF PLANTS PRODUCING ORGANUCHLURINE PR ODUCTS ( LEVINA, M. M. / FILATOVA, V. S. / BELAYA, E. G. ASHIROVA, S. A. / TIKHOMIROV, YU. P. / LEVIN, A. L. MOSTINSKrtYA, P. Z. / KUZNETSKlI, P. E. i INST. GIG. TR. PR0F7AB0L / GORKI / USSR GIG. SANIT. ^ GISAAA, VOL , ISS 4 ,YR 73,PGS 8b- 7 , SEC 59 /./KEY WOkDS// ORGANCCHLOP. iNh MANUF HYGIENIC CERTIFICATION PVC MANUF HYGIENIC CERTIFICATION. ( ' VINYL UltOxIiJL MAilUF HYGIENIC CER TI F ICATIUN P(ILYCHLUkOPKr_:jE MANUF HYGUNIC CERTIFICATION TRICHLOROETHYLENE MANUF HYGIENIC CERTIFICATION ( ACS COPYRIGHT 1973,CA-CONDENSATES c3 790144974Z V0L=79 ISS*25 SEC=17 WT* 9 CA347CARD 13 SANITARY-HYGIENIC PROPERTIES OF COMPOSITIONS MADE OF POLYIV C INYL CHLORIDE) 3 STULOVA, L. I. / SHARGORODSKII, A. M. USSR ^ TR. KHIM. KHIM, TEKHNOL. TKKTAE, VOL ,ISS 3 , YR 1972, PGS 139- 42 //KEYWORDS// i FOOD PACKAGING POLYVINYL CHLORIDE ACS COPYRIGHT 1973,CA-CONDENSATES OLI 2555 w ;. > ,y > ~ v '.M -J ^ y* OLI 2556 131442 Chemical Abstracts 7ol. 76, 1972 Xo Page .710 131442n Formulation and stabilization of magistral collyria. with PVC samples did not reveal any changes of consequence. Henschcl, V. (Univ. Liege, Liege, Belg.). Farmaco, Ed. Prat. Irena Kloczko 1972, 27(2), 65-79 (Fr), A series of hypotonic solns. at pH 4.8, 131449v Factors affecting the composition of ultrafiltrate 6.5, and 6,8 contg. the antiseptics benzalkouium chloride, phenyl- from hemodialysis coils. Xolph, Karl D.; Stoltz, Michael L.; mercuric borate, Xa ethylmercurilhiosalieylate or chlorohexidine Carter, Charles B.; Fox, Marianne; Maher, John K. (Med. digluconate were prepd. and sterilized by heating 1 hr at 100 in Cent., Univ. Missouri, Columbia, Mo.), Trans. Amur. Soc. steam or by membrane filtration. These solns. were used prefer Artif. Intern. Organs. 1970, 16, 495-501 (Eng). Solute trans entially according to pH, antiseptic or mode of sterilization in the port during the ultrafiltration from a perfused hemodialysis coil formulation of eye-washes in accordance with the requirements of may be affected directly by the membrane, by a Gibbs-Donnan- the Belgian Pharmacopeia contg, ZnSO,, Nal-KI, Argyrol, like phenomenon related to protein charge, or by an addnl. pro atropine sulfate, procaine-HCl, resorcinol, pilocarpine-HCl, tein affinity. New discrepancies in solute and water removal chloramphenicol, 1% or b% Xa sulfacetamide, BzONa, or Nar during actual hemodialysis may be blunted by augmented dif B|Oj as active constituent. C. R. Addinall fusion. Perfusate protein concn., perfusate pH and ultrafiltra- 131443p Effect of technological parameters on the quality of tion rate may affect solute removal and must be* considered in tablets prepared from granulates produced with industrial fluid* bed granulation equipment. Bank, A.; Bezzegh, D,; Fekete, comparative dialyzer performance studies. Variations in factors affecting solute transport by ultrafiltration will be particularly P. (United Works Pharm. Diet. Prod., Budapest, Hung.). Free. Ctm}. Appl. Phys. Chem., 2nd 1971, 2, 687-92 (Eng). important to those designing dialyzers utilizing primarily ultra- filtration. P. J. Parisek Edited by Buzas, Ilona. Akad. Kiado: Budapest, Hung. The 131450p Liquid-liquid contactor for extracorporeal blood optimal tech, parameters for granulation on lab. scale and pilot plant were investigated for the fluidized bed spray granulator process (FBP). An increase in amt. of binding agent increases mech. strength and decreases wear loss. An increase in flow rate of fluidizing air and decrease in feeding rate of granulation oxygenation. Anderson, Richard Mark; Harris, Grady William; DeFilippi, Richard P.; Weber, David Charles; Malchesky, Paul S.; Nose, Yuirihiko (Abcor, Inc., Cambridge, Mass.). Trans., Amer. SoC. Artif. Intern. Organs 1970, 16, 375-80 (Eng). The concept of continuously contacting blood with a flowing liq., resulted in a particle size decrease. Phys. parameters of tablets obtained by FBP and wet granulation process (WGP) were in good agreement except that crushing strength for FBP tablet was greater than WGP tablet, L, X. Dhoot fluorocarbon film for extracorporeal blood oxygenation and COj removal was demonstrated. A 13-channel parallel-plate device has been tested in vitro and in vivo. It had no effect on hematol. variables during runs on calves for durations of up to 5 hr on 131444q Thermal processes during tableting. Bogs, U.; Lenhardt, E. (Get.). Pharm. Ini. 1971, 33(lla), 850-4 (Ger). Direct temp, measurement on the surface of tablets during tablet ing, with thermocouples welded into the surface of an epoxy resin bottom punch is described. Oscillog. was used to det. the temp, rise. Pressure was measured indirectly. An aminophenazone (I)-starch (50:46) granulation with 6.3% gelatin soln. with and without added lubricants (2% talc or Mg stearate) was used as the test mixt. for 0.5 g tablets. Temp, increase was propor/tional to the pressure used over wide limits, Addn, of lubricant changed the start of the temp, rise at higher pressures. During compression, the temp, rise was followed immediately by cooling to the original temp, when the pressure was released. A eutectic powd. mixt. of 40:45:15 I-dihydropyridine-nicotinamide of low eutectic point (38) alone gave less cooling of the tablet, tablet ing mold surfaces and a progressive temp, rise on further com pression cycles due to the formation of a thermally insulating molten film. During compression, the effect of heat generation on tablet formation and tableting difficulties is discussed. N, M. Khanna 13l445r Therapeutic value of bandaging materials as a func tion of their physicochemical parameters. Xovak, Janos; Molnar, Istvan; Szego, Eva; Huszka, Zoltan (Magy. Kephad- pumpless partial bypass. The oxygenation capacity was shown to be about 600 cc of blood/min, an Oi transfer rate of about 40 cc of Oj/min-M.* The fluorocarbon, FC-43, appears to be chem. inert both in vitro and in vivo. However, a fluorocarbon trap is required on the blood return line to prevent accidental carry-over of FC-43 because it blocked blood flow in capillaries. P. J. Parisek 131451q Extracorporeal chemical reactor. Martel, L.; Rotteveel, J,; Snider, M. T.; Galletti, P. M, (Div. Biol. Med. Sci., Brown Univ., Providence, R.I.). Trots., Amer. Soc. Artif. Intern. Organs 1970, 16, 504-7 (Eng), Biochem. specific ity can be achieved in the case of some low mol. wt. plasma solutes by introducing a high mol. wt. enzyme in a closed dialyzate compartment. The hemodialyzer then acts as an extra- corporeal reactor in which biochem. reactions can be imposed without actually introducing the reagents into the blood stream. This system, dubbed "cascade dialysis" permits lowering blood plasma asparagine levels in dogs to negligible values within 4 hr and maintaining low levels by continuous operation of the bio chem. reactor. The cascade dialysis system may be of value when the selected enzyme Is either rare, toxic or contaminated, or when the development of antibodies must be prevented. P. J. Parisek I31452r Surface chemical evaluation of thromboresistant sereg Kozp. Korhaza, Budapest, Hung.). Gyogyssereszet 1971, 15(11), 411-15 (Hung). The back skin of narcotized rats was materials before and after venous implantation. Baier, R. E.; Gott, V, L.; Feruse, A. (Cornell Aeronaut. Lab., Buffalo, N.Y.). removed from 8 X 6 cm areas and the adhesion-strength of ban Trans., Amer. Soc. Artif. Intern. Organs 1970, 16, 50-7 (Eng). dage strips onto the wound surface was detd. with a self con structed app. Also absorptivity of cotton gauze, cotton tulle alone and impregnated with paraffin, polyurethane sponge and polypropylene gauze was examd. with a stain soln. Polypropyl ene gauze gave the best performance. Bela Lang Over 20 different thromboresistant materials were studied in the' inferior vena cava in small dogs. Three different mechanism became apparent by which various materials become thrombo resistant (a) intrinsic low surface resistance, which became mani fest in erosion resistance, (6) intrinsically high energy surfaces 131446s Adhesion of caries preventive sealing material to the that rapidly form a thin protein film from the blood, (c) materials tooth enamel. Ohsawa, Takeo (Tokyo Dent, Coll., Tokyo, with desorbable surface active agents (heparin, albumin and Japan), Koku Eisei Gakhai Zasshi 1971, 21(1), 53-69 (Japan). surfactants). In all 3 cases a proteinaceous layer must be An improvement of adhesiveness of Et 2-cyanoacrylate and poly- formed from the blood and it is this layer which ultimately will (Me methacrylate) caries preventive seating material to the det. the thromboresistance of the material. The thickness and enamel surface was proposed by treatment of enamel surface nature of this protein film are important. The materials were with various decalcifing soln., such as HC1, phosphoric acid, examd. before and after implantation in the light of these above formic acid, acetic acid, citric acid, pyruvic acid and EDTA. parameters by ir reflectance and by contact angle expts. Polish Of these, the treatment of enamel surface with 3M pyruvic acid contaminated Stellite 21, tridodecylmethylammonium chloride- for 30 sec was the most effective in increasing the adhesiveness heparinized silicone, epoxy surfactants, polystyrene treated with to the sealing material. M. Shimizu albumin, polyurethane-based electret, diamond polished carbon 131447t The addition of glass filler to caries preventive seal and glow discharge-treated Stellite 21 were examd. Horst Kehl ing material. Oishi, Takahiro (Tokyo Dent. Coll,, Tokyo, 131453s Inconsequentially of surface properties for initial Japan). Koku Eisei Gakhai Zasshi 1971, 21(1), 32-52 (Japan). platelet adhesion. Friedman, L. I.; Liem, H.; Grabowski, The effects of addn. of glass filler on the phys. properties of Et 2- E, F.; Leonard, E. F.; McCord, C. W. (Dep. Chem. Eng., cyanoacrylate and poly(Me methacrylate) caries preventive Columbia Univ,, New York, N.Y.). Trans., Amer. Soc. sealing material were studied. The abrasion resistance and hard Artif. Intern. Organs 1970, 16, 63-73 (Eng). Fifteen different ness increased by 70% upon addn. of glass filler, and water types of material were examd. with respect to platelet adhesive absorption decreased. The addn. of glass filler treated with ness by (a) platelet adhesion examd. as a function of exposure 0.05-1.0% Silane A-187 or Silane A-174 was more effective. time to various flow rates and as a function of const, flow rate M. Shimizu but various exposure times, (i) using the same material but plate 131448u Preliminary evaluation of suitability of Polish poly- let adhesion was measured after exposure of the materials to (vinyl chlorides) for medical purposes. Kawecki. Karol; Stanis- heparinized blood, and (c) identical conditions as b but only zewska, Jolanla (Akad, Med., Wroclaw, Pol.). Polim. Med. nonheparinized blood was used. A math, model for platelet 1971, 1(1/2), 45-8 (Pol). Samples of Polish PVC types M 67 diffusion and adhesion was constructed. Either diffusion alone and MW 68 were implanted under the skin and into peritoneal regulated the process, or possibly both diffusion and reaction tissue of rats for 1-90 days. The results were compared with are important. Thetmaterials studied were: glass, siliconized those obtained with Italian PVC Sicron CR-S 3. After 90 days glass, albumin coated glasi, albumin coated siliconized glass, the loss in wt. of the 3 kinds of PVC was 0.0085, 0.0066, and perfluorinated octanolVolymethacrylate, poly(vinylpyrrolidone), 0.0294 mg. Histol. examn, of internal organs tissues in contact cellophane, cellulose acetate, fluorinated ethylene propylene 7 (, , 7/c/r/J?^, I 'age 107 4--Toxicology Vol. 76,1972 95348 Tarbon monoxide [630-08-0] poisoning was induced in rats maintained in an airtight plexiglass box contg. Na lime, and in which the 03 was supplied from a cylinder and its amt. was controlled. Calcn. of CO introduced was corrected for the vol. of animal bodies. CO poisoning (5 mg CO/1.) resulted in an increase of the ERYTHROPOIETIN LEVEL in blood plasma after 2 hr. D. F. Kalab 95339y Determination of lead in plant films with a portable isotope fluorescence analyzer. Barltrop, D.; Harford, C. L.; Killala, N. 3. P. (Pediatr. Unit, St. Mary's Hosp. Med. Sch., London, Engl.). Bull. Environ. Contam. Toxicol. 1971, 6(6), 502-8 (Eng). The application of x-ray fluorescence to the detn. of lead [7439-92-1] content of PAINT FILMS was evaluated using a portable isotope fluorescence analyzer. Accurate detns. were achieved in the laboratory using prepd. films in which the Pb was dispersed through matrices of constant compn. in a single layer. The presence of Pb, however, was masked by overlying paint films of low Pb content and was almost obscured by an overlying paint film of 77 mg/cm2. The results for commercial paint films correlated with chem. analyses but the confidence limits were too widely separated to allow application of this technique to Pb screening programs. In the field, the apparatus was incapable of discriminating between Pb contents of commercial paint films in the 0-6% range. 95340s Use of electron microscope to detect organic phosphate-induced demyelination. Ezell, W. Bruce, Jr.; Adkins, Theodore R., Jr. (South Carolina Agric. Exp. Stn., Clemson Umv., Clemson, S. C.). J. Econ. Entomol. 1971, 6416), 1345-8 (Eng). Electron microscopy indicated that i demyelination in chicken PERIPHERAL NERVES occurred as early as 4 days after treatment with 1 g TOCP (tri-o-cresyl phosphate) (I) (78-30-8l/kg, whereas paralysis was not obsd. until the 10-12th days posttreatment. | 9534It Organophosphate degrading enzymes in the crude 'supernatant fraction from the rat liver. Miyata, Tadashi; Matsumura, F. (Dep. Entomol., Univ. Wisconsin, Madison, Wis.). J. Agr. Food Chem. 1972, 20(1), 30-2 (Fr). Four distinctly different types of enzymes which degraded INSECTICIDAL ORGANOPHOSPHATES in the crude supema= tant fraction (20,000 g supernatant) of rat liver, were classified on the basis of cofactor and ion activation characteristics. The enzymes which degraded malathion [121-75-5] and parathion [56-38-2] were detected by the electrophoretic method. Electrophoresis treatments did not, however, facilitate the detection of Ca2+- or GSH-stimulated enzymes. Most of the ESTERASES detected in rat liver supernatant by using 1-naphthyl acetate did not appear to be important in degrading organophosphates. 95342u Urinary aflatoxin B and effects of preservatives on its detection. Parpia, H. A. B.; Sreenivasamurthy, V.; Shantha, T.; Shankaramurti, A.; Srikantia, S.; Amla, 1. (Cent. Food Technol. Res. Inst., Mysore, India). Amer. J. Clin. Nutr. 1972, 25(1), 13-15 (Eng). The suitability of Leeds, Engl.). Chem.-Biol. Interactions 1972, 4(4), 297-303 (Eng). An ISOPYCNIC GRADIENT TECHNIQUE was developed for measuring the interstrand cross-linking of DNA in mammalian cells after treatment with DIFUNCTIONAL ALKYLATING AGENTS, such as mustard gas [505-60-2], HeLa cells were grown for 3 hr in a medium contg. 5-bromodeo= xyundine [59-14-3] and then resuspended in a medium contg. labeled thymidne [50-89-5] to label heavy DNA. Treatment with mustard gas caused covalent chem. bonds between the light unlebeled and heavy labeled DNA, which appears as a sep. radioactive peak or shoulder of intermediate d. after cesium chloride gradient centrifugation. Moderately high doses of drug must be used before cross-linking can be readily measured reproducibly. 95345x Controlling the cytotoxic activity of components of plastics components used in pharmacy. I. Evaluation of poly(vinyl chloride) and its components using a phytobiologic= al test- Brzezicka-Bak, Maria (Zakl. Mater. Med., Inst. Lekow, Pol.). Farm. Pol. 1971, 27(11), 865-71 (Pol). In the presence of poly(vinyl chloride) [9002-86-2] water or alcohol exts., cress (Lepidium sativum) seeds showed, after 4 days, up to 16% slower germination and cress roots up to 31% growth inhibition. Decreases in germination and root growth of up to 16 and 50%, resp., were also obsd. after exposure of cress seeds to solns. contg. the po!y(vinyl chloride) PLASTICIZERS diisooctyl phthalate (27554-26-3] and Plastol 10, or the STABILIZERS tine laurate [2452-01-9], calcium laurate [4696-56-4], and Ergoterm OTGO [16089-37-5]. Although the po!y(vinyl chloride) components used showed interference with germination and growth, further testing is needed before using this phytobiol. test as a criterion in detg. the cytotoxity of plastic constituents. 95346y Rapid thin-layer chromatographic method for the identification of organophosphates in blood. Paez, D. M.; Farah, M. (Fac. Cienc. Fis. Quim., Univ. Nac. Cuyo, San Luis, Argent.). Rev. Asoc. Bioquim. Argent. 1971, 36(194-195), 127-31 (Span). Four ml of a sample of blood suspected of (E,O)Jo-H0>--no*, "*<VSCHC0jE. ^ contg. parathion (I) [56-38-2], malathion (II) [121-75-5], or their metabolites paraoxon [311-45-5] or malaoxon [1634-78-2], were extd. with acidic ethyl ether-petroleum ether (3:7). The condensed ext. was chromatographed on silica gel thin layers using either n-hexane-acetone (5:1) or cyclohexane-acetone-chlo= reform (7:2.5:0.5) as developing solvent. Spots were revealed using either 4-(p~nitrobenzyl)pyridine [1083-48-3] or bromphenol blue [115-39-9] color reagents. The limit of detection was 1 ppm in blood. 95347z Importance of thin-layer chromatography for the identification in urgent toxicological analysis of l,4-benzo(f= ldiazepines used in therapeutic treatment. Lafargue, Paul; Meumer, Jean; Lemontey, Yves (Ec. Appl. Serv. Saute Armees, Hop. Instr. Armees Val-de-Grace, Paris, Fr.). J. Chromatogr. 1971, 62(3), 423-9 (Fr). Benzodiazepine derivs. * oo OLI 2557 cx s>t> I hydrochloric add [7647-01-0], chloroform [67-66-3], Me ale, [67-56-1], and formalin [50-00-0] as urine preservatives for aflatoxin anal, was examd. Both HC1 and formalin were unsuitable as preservatives in monkey urine contg. added aflatoxin Si (I) [1162-65-8]. Seven percent of utine samples from children contained aflatoxin the identity of which was detd. by known methods. 95343v Thin-layer chromatographic comparison of Commercially available silica gel coated films and sheets with silica gel coated glass plates, demonstrated on toxicologicaUy interesting substances. Schweda, Paul (Off. Lhief Med. Exam., Baltimore, Md.). J. Chromatogr, 1971, 63(1), 67-72 (Eng). Chromatog. data from com. silica gel layers na flexible films and glass fiber sheets are compared with those trom handcoated silica gel glass plates for a ho. of drugs of to4*eol. interest. Running rates, relative running rates, solvent and general characteristics of the different media for THpJ-LAYER CHROMATOG. are reported. 95344w Estimation of interstrand DNA crosslinking iffuifing from mustard gas alkylation of HeLa cells. Ball, C. Roberts, J. J. (Dep. Exp. Pathol. Cancer Res., Sch. Med., present in urine were hydrolyzed to the corresponding BENZOPHENONES and HEXAHYDROACRIDINONES. Condensed ether exts. of the hydrolysis products were chromatographed on alumina thin layers using benzene-chlorofor= m (3:1) as solvent, and spots were revealed by fluorescence or diazocoupling. Depending on which hydrolysis products were detected on the chromatog. plates, the drug originally ingested was identified as belonging to 1 of the 4 groups: diazepam (1) [439-14-5] and medazepam [2898-12-6]; chlordiazepoxide [58-25-3], clorazepate [15585-90-7], and oxazepam [604-75-1]; nitrazepam [146-22-5]; or tetrazepam [10379-14-3], Gastric juice benzodiazepine hydrolysis products were identified either by the above thin-layer chromatog, method, or by known spectrofluorometric or gas chromatog. methods. 95348a Identification of rotenone in fish poisoned by derris root resin. Sinnappa, S.; Thuan, Chang Eng (Dep. Chem., Minist. Agric. Lands, Petaling Jaya, Malav.). Malaysian Agr. J. 1971, 48(1), 20-4 (Eng). A METHOD of extg. and identifying rotenone (I) 183-79-4] in fish poisoned by derris root resin was described. Acetone [67-64-1 j was used for exln. and thin layer chromatog. was used for detection of I, the active 81811 Chemical Abstracts Vol. 76, 1972 b'J. Page 83 Horce D. Academic: London, Engl. A REVIEW of the biochemistry and mode of action of B, thuringiensis protein crystal toxin, 75 Refs. 81812b Thermostable exotoxin of Bacillus thuringiensis. Bond, R. P. M.; Boyce, C. B, C.; Rogoff, M. H.; Shieh, T, R. (Milstead Lab. Chem. Enzymol., Shell Res. Ltd., Sittingbo= ume/Kent, Engl.). Microbial Contr. Insects Mites 1971, 275-303 (Eng). Edited by Burges, Horce D. Academic: London, Engl. A REVIEW on the assay, purification, chemistry, and biol. activity of the exotoxin-, 64 refs. 81813m Effects of oxygen upon ophthalmic structures. Nichols, Charles W.; Lambertsen, C. J. (Med. Cent., Univ. Pennsylvania, Philadelphia, Pa.). Underwater Physiol,, Proc. Symp., 4th 1971, 57-66 (Eng). Edited by Lambertsen, Christian J. Academic: New York, N. Y, A REVIEW of the physiol, and pathol. effects of oxygen [7782-44-7] on ophthalmic structures, such sb the cornea and lens with 36 refs. 81814n Modification of the leaf surface and its environment by pollution. Saunders, P. J. W. (Natl. Inst. Agric. Bot., Cambridge, Engl.). Ecol, Leaf Surface Micro-Organisms, Proc. Int, Symp. 1970 (Pub. 1971), 81-9 (Eng). Edited by Preece, T. F. Academic: London, Engl. A REVIEW and discussion on the effect of atm. pollution on leaf surface microorganisms, with 39 refs. 81815p Goals and perspectives of toxicology. Fink, Zdenek; Kabes, Jan (Vojen. Lek. Vyzk. Ustav, llmv. J. E. Purkyne, Hradec Kralove, Czech.). Prac. Lek. 1971, 23(8), 279-84 (Czech). A REVIEW with 9 refs. The necessity of further development of toxicol. is conditioned by increasing use of chems. in the environment. L. J. Urbanek 81816q Toxicological aspects of the utilization of organic tin compounds in poly(vinyl chloride) processing. Wexler, T. (Rom.). Mater, Plast. (Bucharest) 1971, 8(11), 600 (Rom). A REVIEW with 3 refs, on the toxicity of DIBUTYLTIN and DIOCTYLTIN DERIVS. used in polylvinyl chloride) [9002-86-2] processing. 81817r Peritoneal dialysis. Review. Mattocks, Albert M.; El-Bassiouni, Emad A. (Sch. Pharm., Univ. North Carolina, Chapel Hill, N. C.). J. Pharm. Sci. 1971, 60(12), 1767-82 (Eng). The uses of peritoneal dialysis in the treatment of RENAL FAILURE and BARBITURATE and DRUG POISO= NING and in the removal of endogenous and exogenous TOXINS were, reviewed, 274 Refs. 81818s Experimentally induced gastric adenocarcinomas. Stewart, Harold L. (Natl. Cancer Inst., Natl. Inst. Health, Bethesda, Md.). Lab. Invest. 1971, 25(6), 672-4 (Eng). The various chem. compds. which, alone or in combination, produce adenocarcinoma of the stomach in exptl. animals were REVIEWED. Incidence, criteria for diagnosis, and different routes of administration in mice, rats, guinea pigs, and hamsters were discussed. 7 Refs. 81819t Thin-layer chromatography of alkylating substances with 4-(4'-nitrobenn'l)pyridine (NBP). Norpoth, K.; Schri= ewer, H.; Rauen, H. M. (Hyg.~Inst., Univ. Muenster/Westf., Muenster, Ger.). Arxneim.-Forsch. 1971, 21(11), 1718-21 (Ger). Twenty-one compds. were tested for their ability to O"cM*_O"N0i'Hci4 i alkylate 4-{4`-nitrobenzyl)pyridine perchlorate (I) [2590-94-5] using 7 thin-layer chromatog. systems on silica gel at 140. Only cyclophosphamide [50-18-0] and its analog, 3-(2-chloroethyl)-2~(2-chloroethylamino)tetrahydro-2H-l,3,2-oxazaphosphorine 2- oxide [3778-73-2], had the same profile. These 2 compds. could not he investigated by paper chromatog. either. The sensitivity of this thm-layer chromatog. system to CHLOR= OETHYLAMINE COMPDS. was greater than that of paper chromatog. or spectroscopic anal. Quant, evaluation by chromatogram-spectroscopy may be possible. 81820m Adsorption of polychlorinated biphenyls (PCB) on glass surfaces. Hattula, Marja L.; Karlog, O. (Inst. Pharmacol. Toxicol., R. Vet. Agric. Univ., Copenhagen, Den.). Dan. Tidsskr. Farm. 1971, 45(7), 259-61 (Enp. Anal, measurement of polychlorinated biphenyls (PCB) is hindered by a strong adsorption of PCB from water solns. to glass surfaces. Insignificant adsorption, however, was obsd. when aluminum [7429-90-5] containers were used. Adsorption was higher onto older glass than onto silicone coated new glass, but adsorption was still significant in storage vessels. 81821n Rapid method of determination of barbiturates in biological fluids. Rouzioux, J. M.; Armand, J.; Bernon, H.; Badinand, A. (Lab. Cent. Chim. Biol. A, Hop. Edouard-Her= riot, Lyons, Fr.). Bull. Trau. Soc. Pharm. Lyon 1971, 15(1), 3- 12 (Fr). A rapid (20 min), highly reproducible method for detg. blood barbiturate levels was described. The method involved dichloroethane [1300-21-6] and NaOH extractions; for 8 barbiturates tested the mean per cent of extraction was 80%. the optical densities of 2 uv spectra obtained at 260 nm end pH's of 10 and 13.5. The error involved in the method v,.-s decreased when results were expressed as pmoles/1. rather then as mg/1. 81822p Stability of rat liver ribonucleic acid in vivo after metbylation with methyl methanesulfonate or dimethylni'.rosamine. McElhone, Marilyn J.; O'Connor, P. J.; Craig, W. (Paterson Lab., Christie Hosp, and Holt Radium Inst.. Manchester, Engl.). Rinchem. J. 1971, 125(3), 821-7 (Em- The half-life of the rate of disappearance of MC-labsl(.d 7-methylguanine [578-76-7] from RNA isolated from the liver <>: rats treated with either MC-labeled methyl methanesulfona`[66-27-3] (2 mg/kg) was ~3.5 days. The estd. biol. HALF-LD OF RNA using 'H-labeled orotic acid [65-86-1] was 5 day Reutilization of labeled RNA degradation products followin' orotic acid-'H may result in an overestimation of the half-h:- Non-toxic doses of the methylating agents may provide a better measure for estg. the biol. turnover of rat liver RNA than use o: orotic acid. 81823q Uncorrelated thin layer chromatographic systems for the identification of basic drugs. Smalldon, K, W. (Home Counties Forensic Sci. Lab., Aldermaston/Berkshire, Engl... Forensic Sci. Soc., J. 1971, 11(3), 171-6 (Eng). The R, value", for 50 relatively common basic drugs having NONPHENOT= HIAZINE BASES were detd. in 5 chromatographic systems using Merck PRECOATED PLATES. In the choice of thin layer chromatog. systems for use combinations, a compromise must he made between ideal R, frequency distributions and low correlation coefficients. 81824r Detecting tubocurarine in tissue. Stevens, H. M.; Fox, R. H. (Home Off. Cent, Res. Establ., Aldermaston/Rea= ding/Berkshire, Engl.). Forensic Sci. Soc., J. 1971, ll(3i. 177-82 (Eng). The method used for the extn. of d-tubocurarin* (I) [57-94-3J from LIVER tissue consisted of protein removal, alkylation of the soln., and removal of interfering bases by shaking with dichloromethane [75-09-2]. I could then be extd and estimated by uv spectrophotometry. Thymine [65-71-4; and tyramine [51-67-2], 2 commonly occurring putrefactiveproducts in liver tissue, could be sepd. from I, by a thin-layer chromatog. system using Merck precoated alumina plates. 81825s Determination of arsenic in coal and in insecticides by atomic absorption spectroscopy. Spielholtz, Gerald I: Toralballa, Gloria C.; Steinberg, Ralph J. (Herbert H. Lehmar Coll., City Univ. New York, Bronx, N. Y.l. Mikrochim. Actc 1971, (6), 918-23 (Eng). Following the decompn. of org. mattein coal and insecticides by WET COMBUSTION with perchloric acid plus periodic acid, arsenic [7440-38-2] could be detd. by at absorption spectroscopy. The method was rapid and efficient, and no loss occurred by VOLATILIZATION during sampl- prepn. The sensitivity of the method was enhanced over that of the normal aspiration technique by utilizing the sampling boat accessory. 81826t Biochemical screening test with [HC 1-glucose and [32p]-phosphate for the evaluation of embryotoxic effects in vivo. Krowke, Ralf; Siebert, Gabriele; Neubert, Diether (Pharmakol. Inst., Freien Univ. Berlin, Berlin, Ger.l Naunyn-Schmiedebergs Arch. Pharmakol. 1971, 271(3), 274-88 (Eng). Embryotoxic effects of drugs were screened biochem with the i.v, injection of uC-labeled glucose [50-99-7] or 3zP-labeled phosphate [14265-44-2] into various exptl. animals. These unspecific precursors were incorporated into a variety of acid-insol. cell components by various metabolic pathways, and did not induce an alteration in the concn. of any of the intermediary products of CELL METABOLISM. The radioac= tivity of incorporated lipids, RNA, glycosaminoglycans, DXA and proteins was measured, using a simple fractionation procedure and a double labelling technique. The applicability and limitations of this METHOD were discussed. 81827u Determination of bis(p-chlorophenyl)acetic acid in urine. Krechniak, Jerzy; Dubrawski, Raimund (Zakl. Chem Toksykol., Akad. Med. Gdansk, Gdansk, Pol ). Bromatol. Chem. Toksykol. 1971, 4(3), 281-5 (Pol). The DDT [50-29-3' CHCOjH 2I OLI 2558 metabolite, bis{p-chlorophenyl)acetic acid (I) [83-05-6], present in rat and human urine samples, was freed by hydrolysis and extd. with ethyl ether. After purification by reextn. into 2% NaOtt solns., I was detd. by the method of Schechter and Haller. Recovery of I from animal and human urine samples was 98 and 94%, resp. In human subjects who were not professionally exposed to DDT, a mean value of 0.05 mg I/kg urine was detected. 8I828v Fractionation of coral snake venom Separation and characterization of the protein fractions. Ramsey, Howard W.; Snvder. Gregnrv K Kitchen T-h'-em- Tev'nr V, 76067 Chemical Abstracts Vol. 76, 1972 S'S. Page 2% tions typical of recreational fires. The exptl. parameters were quantity of charcoal, air supply, arrangement of the briquets, and the method of ignition. CO yields depended primarily on factors that affected the reaction temp., i.e., the availability of 0 and fuel arrangements that generate the hottest fires. In a sealed compartment the CO concn. reached a satn. level of ~0.5- 0.7%. Prior to equil. the max. yield was ^0.3 g CO/'g charcoal consumed. 76068t Absorption and emission by sulfur dioxide between 1050 and 1400 cm"C Burch, Darrell E.; Pembrook, John D.; Gryvnak, David A. (Aeronutron. .Div., Philco-Ford Corp., Newport Beach, Calif.). U.S. Nat. Tech. Inform. Sen., PB Rep. 1971, No. 203523, 59 pp. (Eng). Avail. NTIS. From Govt. Rep. Announce. (N-S.) 1971, 71(23), 66. The absorp tion by the m (1151.38 cm-1) and (1361.76 cm-1) bands of SOj was studied between 1050 and 1400 cm-1. Spectral curves of transmittance were scanned with ~1 cm-1 resolution for >200 samples varying in temp, from ~296 to 575K and in pressure from 0.01 to 16 atm. The objective was to provide data on SO> absorption and emission that are required to inter pret data obtained in this spectral interval on the emission by smokestack exhausts contg. SOj. An extensive table pro vides information from which the emission between 1050 and 1250 cm-1 can be ealed. for temps, between 296 and 650K. Water vapor absorbs and emits so strongly in the region of the ej band of SOj that this band is probably not useful for remote sensing of smokestacks. Therefore, the in band was empha sized. The strengths of the 2 prominent bands in mols. are: M, (371 20) X 10!" and r,, 3020 200) X 10". 76069u Induced radioactivity. II. Air and water con tamination. Goebel, K.; Prantl, Friederike; Stevenson, G. R.; Vialettes, H. (Radiat. Group, CERN, Geneva, Switz.). CERN (Eur. Organ. Nucl. Res.) IRep.] 1971, CERN 71-21, 116-26 (Eng). Radiation problems arising from activation of the water used for cooling magnets, radio-frequency cavities, targets, and beam dumps is discussed. The extent of soil and ground water activation near the accelerator site is estd. Ests. are also made of airborne activity in the form of dust and radio isotopes produced in the air. W. W. Brown 76070a Morning vehicle-start effects on photochemical smog. Martinez, J. R.; Nordsieck, R. A.; Eschenroeder, A. Q. (Gen. Res. Corp., Santa Barbara, Calif.). U.S. Nat. Tech. Inform. Sere., PB Rep. 1971, No. 203872, 41 pp. (Eng). Avail, NTIS. From Goat. Rep. Announce. (U.S.) 1971, 71(24), 113. The influence of cold-start vehicle emissions on air quality is investigated using a photochem./diffusion model. Both the time and space distribution of cold starts are examd. Emis sions introduced during the starting process have the greatest effect of all on CO peaks, the effect being to increase the peak CO concn. from 9 to 13%. The levels of Os and NOs that build up later in the day are influenced less because chem. processes afford diln. time. If vehicle starts are decentralized geog., only a slight increase in the pollutant loading is noted because of the low morning speeds. Three possible weighting schemes are proposed for combining cold-start and hot start driving cycles. 76071p Catalytic control of NO, emissions from mobile sources. Seegall, Manfred I.; Napier, James C.; Compton, William A. (Solar, San Diego, Calif.). U.S. Nat. Tech. Inform. Serv., PB Rep. 1971, No. 204011, 142 pp. (Eng). Avail. NTIS. From Govt. Rep. Announce. (U.S.) 1971, 71(24), 116. The project investigated the use of various catalytic media to control N oxide emissions from motor vehicles. Lab. tests of various compds. were conducted. The compds. tested included rare earth oxides, Pt, Pd, Cu dichromate, and modified Monels. The modified Monel compds. were most effective in reducing N oxides. 76072q Fuel additives and automobile exhaust emissions. Fleming, R. D,; Marshall, W. F.; Allsup, J. R. (Energy Res. Cent., Bur. Mines, Bartlesville, Okla.). U.S. Nat. Tech. Inform. Serv., PB Rep. 1971, No. 203894, 15 pp. (Eng). Avail. NTIS. From Govt. Rep. Announce. (U.S.) 1971, 71(24), 182. The influence of fuel additives on exhaust emissions was studied using automotive engines currently found in the U.S. vehicle population. The fuel additives used were 4 multifunctional additives and one Pb antiknock additive. No significant direct effect on exhaust emissions was found for the multifunctional additives tested. Also, detergent-dispersant additives had little influence on emissions when used in conjunction with high- quality oil and motor fuel. The Et,Pb antiknock additive in creased exhaust hydrocarbons ''-12-17% during a 4000-mile accumulation period using a base fuel contg. 2 ml of EtrPb/gal. An unleaded fuel was used during a similar accumulation period with no increase in exhaust hydrocarbons with mileage. 76073r Exposure of marigold (Tagetes) to gaseous hydrogen chloride. Lind, Christopher T.; London, Sheldon A. (Aerosp. Med. Res. Lab., Wright-Patterson Air Force Base, Ohio). U.S. Nat. Tech. Inform. Serv., AD Rep. 1971, No. 732195, 18 pp. (Eng). Avail. NTIS. From Govt. Rep. Announce. (U.S.) 1971, 71(24), 31. To ascertain the extent of environmental pollution problems attendant with Air Force missile operations, mature flowering marigold plants were exposed to one of the known exhaust products, HC1. All plants died after 5 min ex posure to 2071 ppm, the highest concn. used. At 95 ppm n effect was noted. Seeds obtained from the exposed plants did not appear to be affected by the HC1 treatment. 76074s Automated instruments in air pollution monitoring systems. Thiele, Bevan R. (Div. Air Pollut. Control, Pep. Health, Brisbane, Aust.). Clean Air (Heidelberg, Aust.) 1971, 5(4), 65-70 (Eng), A detailed account is given of air pollution monitoring systems, and their application to the Australian urban situation. W. Strauss 76075t Possible effects of aircraft flying in the stratosphere. Bigg, E. K. (Div. Radiophys., CSIRO, Epping, Aust.). Clean Air (Heidelberg, Aust.) 1971, 5(4), 57-9 (Eng). Particles have been collected at heights between the ground and 40 km over Australia. Particles >0.1 pm are confined to 15-25 km, with a mean of 0,3 pm and a max. size of 2 pm, and this layer is world wide. In general these panicles are (NH,);SOt> but HuSO, droplets have predominated following the volcanic eruption in Bali in 1963. In the 0-10 km layer in Central Australia (NHt)j- SO< predominates. High flying supersonic aircraft will inject water vapor into the 22-km layer and cause swelling of the acid droplets, leading to either greater deposition rates or more light scattering, or both. W. Strauss 76076u Infrared spectrographic technique for analysis of flue products from gas-fired appliances. DeWerth, Douglas W. (American Gas Assoc., Inc., New York, N.Y.). Amer. Gas Ass., Oper. Sect., Proc. 1971, D45-D48 (Eng). A dispersive ir spectrophotometer set-up with an absorption spectrum range of 2.5-25 m can be used to det. directly and rapidly trace concns. of NO, NOj, SOi, CO, CH4, CsHt, and total aldehydes in flue gases of gas-fired home appliances. Gas anal, results can be re produced with an error <1%; NOs and SOs results agree to 4%, with wet chem. checks. 76077v Removal of dust and fumes from waste gases. Lancashire, R. (Process Eng. Div., Newton Chambers Eng. Ltd., Thorndiffe/Chapeltown/Sheffield, Engl,). Environ. Pol lut, Manage. 1971, 1(1), 29-31 (Eng). Efficient cleanup (< 99.9%) of waste gases at inlet concns. <5872 mg/m1 can be at tained by the use of a high-energy (pressure drop of 50-3000 mm water) Venturi scrubber (annular clearance washer) which con sists of a single large Venturi tube in which an axially adjustable displacement cone is fitted to form the gap through which the dust laden gases pass at high velocities. A system requiring al most no make-up water is described and can clean <3 ton dust/20 min produced during O blowing in a 200 ton converter. 76078w Activated carbon adsorption processes for preventing air pollution. Krill, Helmut; Storp, Klaus (Lurgi Ges. Waerme- und Chemotech, m.b.H., Frankfurt, Ger.). Environ. Pollut. Manage. 1971, 1(1), 8-15 (Eng). A discussion is given on the production, by gas and chem. activation processes, of various grades of activated C and their utilization in waste and exhaust gas purification in the Supersorbon, Sulfosorbon, and Sulfreen processes. Flow diagrams are given for the 3 processes together with cleanup efficiencies and S recoveries attained in viscose plants (by the Sulfosorbon process) and in waste gas desulfuriza tion (by the Sulfreen process). , 760791 Handling vinyl chloride emergencies. Dowell, Df, L. (B. F. Goodrich Chem. Co., Cleveland, Ohio). Loss Prev. 1971, 5,29-31 (Eng). The potential hazards from the accidental loss and combustion of tank car amts, of vinyl chloride monomer (VCM) are discussed, and procedures for handling VCM tank car and marine transport emergencies are listed. Modeling indicated that the burning of VCM under sp. conditions (pre mixed with O) can produce a phosgene concn. of 20-40 ppm and in tank car loads (200,000 lb) would produce a ground level HC1 concn, of 5 ppm to a distance of 10,000 ft. 76080r Specific method for the determination of ozone in the atmosphere. Sachdev, Sham L.; Lodge, J. P., Jr,; West. Philip W. (Coates Chem. Lab., Louisiana State Univ,, Baton Rouge, La.). Anal. Chim. Ada 1972, 58(1), 141-7 (Eng). A simple, sensitive, and specific method for the detn. of Oj in the atm. is described. Reactions of Oj with several 1-alkenes were studied at 25. Engenol, when treated with Oj, was found to produce relatively large amts, of HCHO compared to other 1- alkenes tested. The method described was compared with the alk. iodide method for the detn. of various concns. of Oj in the range 0.05-2.0 ppm. HiOt, peracetic acid, SOi, and various re ducing agents commonly present in the air, do not interfere. HCHO, when present in the air, must be detd. simultaneously and the concn. of HCHO subtracted from that of the Oi. Any HCHO monitoring equipment can be easily adapted for the detn. of O,. 76081s Bromine and chlorine loss from lead halide auto mobile exhaust particulates. Robbins, John A.; Smtz, Franklin L. (Dep. Environ: Ind. Health, Univ. Michigan. Ann Arbor, Mich.). Environ.m$ci,`Technol. 1972, 6(2), 164-9 (Eng j. Fresh automobile exhaust particulate matter introduced into a 10-m1 transparent, outdoor enclosure was analyzed for Br and Cl by neutron activation anal, and for Pb electrochem. Particles in 7/ ~ 7 9 J'nRi'M I'm-eBa Tmicuhr v Vi.l 76, 1972 t) `i. 68838 Il* T,** it.m * - 3.) cm* I'm- * `i, y.r i : }. / T'r <-V.) fr*-?; fu^rv.;,; JV-. f*rd ns vital jc-Mnl n JD7i, tvountl.K 'Taijon?,, in or ir i withm uric* is tt such gethcr A. A,; dlnnds, 1971, rnminc ct the ted to when icantly .g. the 'versed EtOH plus B Kin. ion. Roda, EtISC1 lUtnnn i with rt-life i the i, and IV. ise of lideo; pan), al. of The lowed dual, head a on ligan Res. ts of dfish onia. 17-3) e of the NT. mne 6-2) but > [fes re= Ich. -C9 ark. rj ons red =:s. by ri().* r ;v: Mi I ml' i.r 1 '! Mil-.;: ' n i.n e.-' ru^ ii ( . -- it - r lie ccntroN Mil-'iic M. Cl i rt,'It-,. r,t I.-, c.iv . ElDNi-.Y i l NCI P >N I- ii, oiicrra- on iia\ 2 nr (ri'.f.i to I". ,mri 7 0 of 1,^2"i Hi.lc of the microsomal electron transport system in ,1,1 hr'iiiiniuMi-tl' Ilf I .(rlniii (otraeliloride and cth.mol y; i.tonif l | mi., Bahunore. Mil P 1071 |.[t, iRngi. \v.nl Con. Microfilms. Ann Arbor, MiVli.. Ordir No 71 _'9,]56 I r.ini DNs. Ahstr. Int. B llJ71, ,12irn. 2s! 1, , ., , . 6S828a Comparison of cerebral toxicity or monomeric and trimcrie forms of sodium iothalamnte. Dnust. Bruce I)., f'ltrher, Harrs W, iDcp. Radio!.. Wayne Cty. Gen. Hosp., Kloise, ' MichJ. /int. J. Radiol. 1971, 44(520 , 764-G (Engl. co?nq /r^ SOjNO I r 11 was shov. n following I feeding for jS weeks. 6,s,s,33v C\ totoxic effect of fusidin in tissue culture. Cora.-nnma. K S.: Botvina, E. K.; Rlvumkin, V. N. 4Al: l"mon Re-.. Iit'.t. Ant linn;.. Moscow, I'.SSRi. Antibiatihi iMoscow) 1971, IGtll), 100.! ii (Russ). .Vn fusidin (I) |77.l-94-01 at 10, GO, or 1(H) eg ml hud no cytotoxic effects on chnk embryo fibroblast cultures ot transplantable monkey \ KKO cells in vitro. I at ,'200 yg, nil prevented further formation of the CELLULAR MONOLAYER and gradually destrnvcd the preformed cellular layer. CKS34z Effict of carbon monoxide inhalation on in vivo drug metabolism in the rat. Montgomery, Mark )L; Rubin, Robert J. (Sch. flvg. Public Health, Johns Hopkins I'niv., Baltimore, Md.). -J. Pharmacol. Exp. Thcr, 1971, 179(3), 4G5-73 (Eng). Preexposure to 1000 or 250 ppm carbon i ; t / i ; i I , : 1 j %/ /N ' Na iothalamnte (I) [1225-20-3] (0.2 and 0.4 ml/kg; 300 mg iodine [7553-56-2]/mll injected into the common carotid artery of dogs had less CEREBRAL TOXICITY (pulse rate, blood pressure) than a soln. of ;Ya lathalamatc trimer [34280-40-5] of the same iodine concn. The difference in toxicity may be due to the difference in the osmotic activity of the 2 CONTRAST MEDIA. 68829h Metabolic reactions in an organism during chronic carbon monoxide intoxication. Datsenko, I. I. (USSR). Paktory Vnesh. Srcdy Ikh Ztiachenic Zdoroe'ya Nasclcniya, Reap. Mczherd. Sh. i070. No. 2. 14G-9 (Russ|. From Ref. 7.h., Biol. Khim. 1971, Abstr. No. 5F2054. Rats and guinea pigs exposed to carbon monoxide [G30-08-0] (0.009-0.018, 0.030-0.040, and 0.03-0.1 mg/1, air) for 1.5-3 months showed an increase in blood cholesterol [57-88-51 levels during the early stages of poisoning and at low CO concns. No changes in heinatnl. indexes were ohsd., but earboxyhemnglobin was detected in the blood. CO may promote the development of ATHER0SC1,= EROSIS. 68830v Effect of qualitatively different proteins on some biochemical blood indexes of animals exposed to the action of elemental sulfur. Kuziv, R. S.; Aleksevich, Ya. 1. (USSR). Fahtory Vnesh. Srcdy Znachenie Ikh Zdoroe'ya Naselcnixa Reap. Mezhved. Sb. 1970, No. 2, 51-5 (Russ). From Ref. Zh., Biol. Khim. 1971, Abstr. No 5F2057. Lengthy (4 month) administr= ation of elemental sulfur [7704-34-91 (9-3 mg/kg, daily) into the stomach of rats caused a decrease in blood catalase and peroxidase activities and in blood SH-group concn. The total PROTEIN, albumin, and globulin levels in the blood changed very little. Casein, when added to the rations, standardized the biochem. indexes, probably by decreasing intoxication. The addn. of soybean protein or meat was less effective. 6883lw Toxicity of plasticized and nonplasticized poiy(vinyl chloride) extracts, stabilized with ethyl crotonate. Sporn, A.; Cirstea, Adriana; Dinu, Ileana; Boghianu, Liana: Ghtzelca, Gabrieia: Ozcranschi, Lucia; Botescu, Elena (Inst. Ig. Sanatate Publica, Bucharest, Rom.). Igiena 1971, 20(6), 323-30 (Rom), Et crotonate (I) [10544-63-5] leached from MtCH.'CHCOjEl J I-stabilized poiylcinyl chloride) (PVC) [9002-86-2] showed low TOXICITY. Exts., obtained by soaking I-contg. PVC in water for 2 months, given orally to young mice slightly impaired the growth and slightly depressed the serum acid phosphatase and succinic dehydrogenase activities. 6S832x Toxicity of the food dye amaranth. Galea, V,; Pftdu, N.; Pop.,, Letitia: Seiidrea, Doina iLah Tovieol., Jr., t. -Med. Farm., Cluj, Rom.I. Igiena 1971, 20|6). 331-6 (Rnm). Ihe FOOD DYE amaranth (I) [915-G7-3I presents some chronic 10XIC1TY', Rats fed 30 mg 1/day for 73 weeks showed G27o mortality as compared to 13% for controls. 1 reduced in the liver the VITAMIN Ji content, and induced histochem. modifications. I feeding fbr-. (0 days increased the glutamic-oxalacetic transaminase activities in the scrum and liver, and the glutamie-pyrueie transaminase activity in the liver. No such monoxide [630-08-0] inhalation for 90 min inhibited the in vivo metabolism of hexobarbital [50-09-9] and zoxaznlammc (1) [61-80-3), resp., by rats in room air. Exposure to the same CO levels for 90 min followed by drug testing in the CO environment significantly enhanced the CO-induccd effect. The prolongation of the pharmacol. responses mav result from a CO-induced inhibition of the HEPATIC MIXED FUNCTION OXIDASE ENZYME SY'STEM responsible for the metabolism of these compds. Inhalation of atmospheres containing lowered oxygen [7782-44-7] concns. also inhibited 1 metabolism. 08835a Effect of peroral administration of dioctyltin and dibcnzyltin bis(isooctyltliioglycolates) on rats. II. Effect on the animals' fertility and the development of fetuses. Mazur, Halina (Zakl. Badama Zywn. Przedmiotow Uzytku. Panstw. Zakl. Hig., Warsaw, Pol.). Roc:. Panstw. Zakl. Hig. 1971, 22(5). 509-18 (Pol). Female rats receiving the pnlvU myl chloride) (9002-SG-2) stabilizer, dioctvltin bis[isooctyirh'.nelyc= olate] [26401-97-8] (20 or 40 mg/kg) before conception nr during pregnancy, showed about 17% incidence of dead ictuses. No dead fetuses were obsd. in female rats receiving dihrn:\!tin bis[isooctxlihioplyeolate] [28G75-S3-4] (18 or 90 mg kg), and the no. of resorptions increased only at the higher dose. No differences were found in the process of skeletal ossification between fetuses of stabilizer-treated females and controls. 68836b Eflect of long-term peroral administration of dioctyl and dibutyl plithalates on rats. III. Effect on fertility and fetal development. Piekacz, Hanna iZakl. Badama Zywn. Przedmiotow Uzytku, Panstw. Zakl. Hig.. Warsaw. Pol.). Roc:. Panstw. Zakl, Hig. 1971, 22(5), 519-2G (Pol). Among female rats receiving dioctyl phthalate III [117-81-7] or dibutyl phthalate (84-74-2), at 1% or 57c of LD-.n before conception and during pregnancy, the animals receiving the higher dose of dibutyl phthalate showed the smallest incidence of live fetuses. In the rats receiving lethal dose ot I or oVr LD.n dose of dibutyl phthalate, decrease in the wt. of fetuses was aiso obsd. No impairment of ossification was noticed in the fetuses of the treated females. 68837c Influence of cadmium on bone salt metabolism. Hirota, Masatosht (Sch. Med., Gifu Univ., Gifu, Japani. Gifu Daigaku Igakuhu Kiyo 1971, 19(1), 82-115 (Japan). Cadmium [7440-43-9] (200 ppm) increased serum calcium [7440-70-2] and alkaline phosphatase as w-eil as urinary Ca and phosphorus [7723-14-0) but decreased serum P. Alter treatment with Cd for 1 year, OSTEOMALACIA AND OSTEOPORO.MS were obsd. lead [7439-92-1] increased serum Ca and P and urinary Ca, while decreasing serum alk. phosphatase and urinary P. F. Koide 68838d Selenium and tellurium in rats. Effect on growth, survival, and tumors, Schroeder, Henry A,: Mitchener. Marian (Dep. Physiol., Dartmouth Med. Sch.. Hanover. N. H.l. J. Niitr. 1971. 101(11), 1531-40 (Engl Among rats receiving 'odium sclenctc [niKMll-t1!. -'1(/; m - ....... [10102-18-8]. or sodium tellurite [10102-20-21. at 2 ppm So "r fo for 1 year after tune of weaning, and al 3 ppin 9C or 2 ppm Tv until natural death, selenite-treated animals showed highest suppression of growth and mortality. In the latter group. 50% of the males were dead at 58 days ol age. Selenatc and tellurite were not toxic in terms of growth, survival, and lungenty. In Se-fed animals, accumulation of So in organs was more than OLI 2560 *7/' f- Jf i / 42467 Chemical Abstracts Vol. 7G, 1972 Page 76 h-glutamic acid (I) [3181-19*8], glutamic acid j5G-?.G-0], and phthalic acid [88*99-3] showed no EMBRYOTOXIC and TERATOGENIC EFFECT when injected i.p. to pregnant mice. 42468h (-)*A"-Tetrahydrocannabinol. Two novel in vitro metabolites. Maynard, D. E.; Gurny, 0.; Pilcher, R. G.; Kierstead, R. W. (Ciiem. Res. Dep., Hoffmann-La Roche Inc., Nutley, N. J.). Experientia 1971, 27(10), 1154-5 (Eng). EtCHWCHICH(R')'' I. RiH, R' * OH D, R'OH, R'*M V-Hydroxy-N-tetrahydrocannabinol (I) [33886-04-3] and 3'-hydroxy-^-tetrahydrocannabinol (II) [33886-05-4] were identified as metabolites of (-)-3l-tetrahydrocannabinol [1972-07-2] following aerobic incubation with the 9,000 g supernatant fraction of male dog liver. 42469j Changes in microsomal lipids of rat liver after chronic carbon tetrachloride intoxication. Comporti, M.; Landucci, G.; Raja, F. (1st, Patol. Gen., Univ. Pisa, Pisa, Italy), Experientia 1971, 27(10), 1155-6 (Eng). Chronic Me(CHilwC0jH | * carbon tetrachloride [56-23-5] treatment of rats caused an enlargement, severe cirrhosis, and a massive fatty infiltration of their livers. The HEPATIC TRIGLYCERIDE CONCN. was increased in the CCL-treated group. Also, fatty acid changes occurred in liver microsomal phospholipids: stearic acid (I) 57-11-4], arachidonic acid [506-32-1], and docosahexaenoic acid 25167-62-8] content decreased, while that of palmitic acid 57-10-3], palmitoleic acid [373-49-9], and oleic acid [112-80-1] ncreased. Phospholipids of microsomes from CCL-treated rats contained smaller amts, of I, linoleic, arachidonic, and docosahexaenoic acids compared to those of control animals. The larger decrement was found in docosahexaenoic acid and the lower one in linoleic acid [60-33-3], PEROXIDATIVE DECOMPN. of lipids of the endoplasmic reticulum may persist after prolonged treatment with the poison. 42470c Experimental lathyrism. Inhibition of d-alanine incorporation by d-aminopropionitrile. Aleo, J.J.; Caramara= ta, A. (Sch. Dent., Temple Univ., Philadelphia, Pa.). Experientia 1971, 27(10), 1161-2 (Eng). The lathyrogen, HjNCHjCHjCN j fi-aminopropionitrile (I) [151-18-8], inhibited the incorporation of structurally similar 3-alanine [107-95-9] into L-929 fibroblasts cells in vitro, suggesting that a degree of competition existed between the 2; however, the effect of I was not truly proportional to the ^-alanine over a wide range of concns. /8-Alanine failed to reverse the effect of 1 on cell growth. Lathyrogens may act as antimetabolites competing with a normal analog for incorporation into developing connective tissues at one or more stages of metabolism. 4247Id Liver damage by protracted ethanol uptake and its reversibility. Turchetto, E.; Cabrini, L.; Costantino Lupi, M. P.; Formiggini, E. (1st. Chim. BioL, Univ. Bologna, Bologna, Italy). Experientia 1971, 27(10), 1167-8 (Eng). Following treatment of rats with 10 or 20% ethanol [64-17-5] in their drinking water for 2 weeks, the biochem. damage induced in LIVER PHOSPHOLIPIDS may be more severe than the accumulation of NEUTRAL FATS, and 2 weeks after the treatment ended, an appreciable reversal of the biochem. pattern was seen, especially in the 107o EtOH-treated group. Liver phospholipid fractions, such as LYSOLECITHIN. SPHIN'GOM = YELIN, PHOSPHATIDYLCHOLINE, PHOSPHATIDYLETHA= NOLAMINE, PHOSPHATIDYLINOSrrOL, PHOSPHATE)YL= SERINE, and CARDIOLIPIN were greatly increased in concn. immediately after cessation of the treatment, while 2 weeks later the values were near normal. 42472c Effect of cerium on drug-metabolizing activity in rat liver. Arvela, P.; Karki, N. T. (Dep. Pharmacol., Univ. Oulu, Oulu, Finland). Experientia 1971, 27(10), 1189-90 (Eng). On the 3rd day after a single i.v. injection of cerium chloride (2 mg Ce/kg) into rats, liver homogenates from the animals oxidized hexobarbital [50-09-9] and demethylated i\-methylaml= ine [100-61-8] at rates which were 31 and 47%, resp.. of the corresponding control values. On the same day, the cytochrome P-450 content of the liver was 53% of the control level, and blood glucose [50-99-7] was 52% of control. The metabolic OLI 2561 functions normalized within 16 days. Cerium may interact with MICROSOMAL PHOSPHOLIPIDS which are needed for the functioning of cytochrome P-450, or it may antagonize Mg- and Ca-enhancement of drug metabolism. 42473f Action of powdered unstabilized polyethylene ND and polypropylene on animals. Shvedchenko, V, S. (USSR). Gig. Vop. Proizvod. Prtmen. Pohm. Mater. 1969, 104-12 (Russ). Mosk. Nauch.-Issled. Inst. Gig.: Moscow, USSR. Powdered polyethylene ND and polypropylene [9003-07-0] given in a single oral dose (3-7 g/kg) to mice, or in a single intratracheal dose of 50 mg to white rats, or inhaled (100 mg/nr1) for 9 months by rats and rabbits showed weak TOXIC EFFECTS revealed in bronchitis, peribronchitis, bronchiolitis and a weak diffused sclerosis of the lungs. A concn. of S mu/m4 is considered as admissible for the factory buildings. 42474g Toxicity of a polymer cement coating based on butadiene-styrene latex for water pipes. Lasgochkina, K. O. (USSR). Gig. Vop. Ih-oizvod. Primen. Polim. Mater. 1969, 163-9 (Russ). Mosk. Nauch.-Issled. Inst, Gig.: Moscow, USSR. Long-term tests showed that cast iron pipes coated with a polymer cement coating (based on butadiene-styrene copolymer [9003-55-8] LATEX) could be used in water supply systems after CONTINUOUS RINSING for 16 days. A significant increase in OXIDIZABILITY was obsd. following a 4-day storage of water in the pipes, although styrene or butadiene were not detected in the water. 42475h Toxicity of a composite waterproofing coating based y on chlorinated poly(vinyl chloride) in water supply systems. /' Zamyslova, S. D.; Kudrin, L. V. (USSR). Gig. Vop. Proizvod. Primen. Polim. Mater. 1969, 182-8 (Russ). Mosk. Nauch.-Issled. Inst. Gig.: Moscow, USSR. Long-term tests showed that a composite chlorinated poly(vinyl chloride) [9002-86-2] coating (contg. crushed CaCOj, talc, asbestos, and alkyd-stvrene varnish) did not affect the PHYSICOCHEM. PROPERTIES or the ORGANOLEPTIC PROPERTIES of water, provided a proper ratio of surface area to vol, of water (1 ro2 coating to 2 m3 water) was maintained. 42476j Toxicity of polymer building materials employed in children's institutions. Gel'tishcheva, E. A.; Khrustaleva, V. A.; Osokina, S. K. (USSR). Gig. Vop. Proizvod. Pnmen. Polim. Mater. 1969, 208-16 (Russ). Mosk. Nauch.-Issled. Inst. Gig.: Moscow, USSR. The use of poly(vinyl acetate) [9003-20-7] as an INTERIOR LATEX PAINT in children's institutions was prohibited due to excessive evolution of toxic substances into the air. The manuf. of furniture from FIBERBOARD based on urea-formaldehyde resin was not recommended either. PAPER LAMINATES were suitable for finishing wood furniture, however, all children's organizations in which polymers were used, should be ventilated at least twice a day for 1 hr. 42477k Folate-catalyzed elimination of formic acid during methanol poisoning. Rietbrock, N,; Herken, W.; Abshagcn, U. (inst. Pharmakol. Toxikoh, Univ. Wuerzburg, Wuerzburg, Ger.). Biochem. Pharmacol. 1971, 20(10), 2613-22 (Ger). CO*H I HOjCCHjCHjCHNMCO- /yVNHi - NHCHj N During methanol [67-56-1] (2g/kg) poisoning, a reciprocal correlation existed between formate (I) [64-18-6] half-life and folic acid (II) [59-30-3] concn. in the PLASMA in man, dog, rabbit, and rat. Treatment of MeOH-poisoned dogs with amethoptenn [59-05-2] (0.75mg/kg orally) caused a marked rise in toxic I concn. in both plasma and urine. On the contrary, therapeutic doses (2.5mg/kg i.v.) of II produced an almost complete lack of I accumulation, presumably due to accelerated elimination of I. 42478m Primary irritation evaluation program study numbers 33-027-69/70 through 33-030-69/70 and 33-032-69/70 through 33-034-69/70. Rowe, Stephen E.; Steinberg, Marshall (Armv Environ, Hyg. Agency, Eagewood Arsenal, Md.). U.S, Clearinghouse Fed. Set. Tech. Inform., AD 1970, No. 867269, 8 pp. (Eng). Avail. NT1S. From Govt. Rep. Announce. (U.S.) 1971, 71(16), 68. Seven candidate INSECT REPELLENTS (ENT-31889, ENT-16750, ENT-20574-aGa, ENT-24828-a, ENT-32447, ENT-20593, and ENT-32844) were evaluated on rabbits for their potential to cause SKIN AND EYE IRRITATION. The data obtained served as a basis for making recommenda = tions concerning their potential use on humans. 42479o Primary irritation evaluation program study. Study numbers 33-004-70, 33-006-70 and 33-015-70. January-^ March, 1970. Spear, William J., Jr.; Steinberg, Marshall (Armv Environ. Hyg. Agency, Edgewood Arsenal, Md ). L.S. Clearinghouse Fed, Sci.Tecn. Inform., AD 1970, No. 870530, 8 pp. (Eng). Avail. NTIS. From Govt. Rep. Announce. (U.S.) 1971, 71(16), 69, In a study of the potential of INSECT 7 ii port ATPase increased etion of heavy synap- Transport ATPase synaptosomes and of 'thondrial fraction a bserved (by C5%). M. Hava rticulate fractions of r, Julian N-l Sargent, Mass.). Lipids 1971, tected in the ability of iking and normal mice -ketodihydrosphingo' CoA into ceramide; sphingomyelin, onucleic acid poly* ,d with Rous sarcoma M. (McArdle Lab. . Wis.). J. Virol, d with the B77 strain aduced no virus-like ic production of inact of the B77 virus _'d to det. the relative irus-infccted chicken much less B77 virus ken cells. RNaseesent in high-speed us-infected rat cells, ells contained lesser olymerase activity, ymerase activity in was not related to I virus. The DNA in high-speed pellet II extent with RNA nt with RNA from n virus 40 antigens is. Tsuchiya, V.; llinois Univ., Car6-60 (Eng). The infection of an cs' cells with simian >usly infected with "[ failed to induce jreinfected with Jected cells was the rate of DNA rred after infection cantly lower than iich had not been ' exert significant feet against SV40 ns of neoplastic eprivation. Lais-t. (Dep. Pathol., 971, 69(1), 57-64 re incubated in a lecific nutritional to acid (L-leucine, imal and various ie concn. of Lell multiplication id cells, whereas e effect on cell > hr. The mean mine was reduced rresponding pre>an, resp.). In culture medium iroxytryptamine ite into protein- f the blood upon n the carotidian a (Univ, Babesyai, Ser, Biol. irt activity and exptl. model of tider conditions d artificially by Hyperkalemia, .1 an inhibitory et both at the , compensated m\c cholinergic maggerates the action on the v/ chromaffin medulo-adrenal cells without a cholinergic inter mediary; in addn., it decreases the lethal threshold of K. Hyper calcemia begins with the specific adrenergic heart effect, soon followed by a marked cholinergic cardiovascular influence, which disappears almost completely owing to the double vagotomy which also diminishes the lethal threshold of hypercalcemia. An equiv. hypermagnesemia does not show remarkable effects on the in situ dog heart, nor on the carotid pressure. Double vagotomy or atropinization of the dog does not induce any other effects. Felix Saunders 2370p Alterations of deoxyribonucleoprotein thermal stability induced by lymphocyte-Ehrlich ascites tumor cell interaction, Alvarez, M. R. (Dep. Biol., Univ. South Florida, Tampa, Fla.). Exp. Coll Res. 1971, 69(1), 72-80 (Eng). Ehrlich ascites tumor cells and normal lymphocytes of the mouse were suspended in isotonic saline and allowed to settle on the surface of glass slides in equal densities. When the tumor cells and lymphocytes were attached to different slides, thermal denaturation of the deoxy- ribonucleoprotein (DNP) was greater in the tumor cells. When the two cell types were mixed and attached on common slides, the DNP thermal denaturation was greater in the lymphocytes and melting occurred at a higher temp, in both cell types. This relation held regardless of the relative proportions of either cell type in a mixt. However, when the tumor cells constituted the majority cell type, the difference in DNP thermal stability was smaller. 237lq Prostatic carcinoma of human origin transplanted in the golden hamster. Abdalla, Ahmad M.; Oliver, John A. (Gavin Miller Mem. Cancer Found., R. Victoria Hosp., Mon treal, Que.). J. Urol. 1971, 106(4), 590-4 (Eng). A trans plantable carcinoma was propagated in the hamster with evidence suggesting that it is a 3-methylcholanthrene-transformed car cinoma. Roland S. Pianotti 2372r Dynamics of RNA secretion into a culture medium by Ehrlich carcinoma cells in a short-lived culture. Ryazant- seva, I. N. (USSR). Sb. Aspir, Rub., Kazan. Cos. Univ., Estestv. Nauki 1969, 129-32 (Russ). Edited by Belyaeva, M. I. Kazan. Gos. Univ.: Kazan, Ukr, USSR. The Ehrlich car cinoma cells harvested the 6th day after transplantation were centrifuged from the ascitic fluid, the damage was controlled by staining with neutral red, and the cells (2-6 X 10*/ml) incubated for 3-3.5 hr at 37" in Hanks soln. with 10% inactivated calf serum. The 2-ml samples of the medium were taken at 30-min intervals. The cells retained their physiol, activity for 3-4 hr, the dead cells averaging 1.5-2%. Using the WP incorporation into RNA and a quant. RNA detn. the RNA content in the cells and in the medium was studied. RNA secretion into the medium increased during the incubation from 21.1 ag/tnl at the beginning to 32.9 at 2.5 hr. At the 3.5-hr interval, when the necrotic cells surpassed the active ones, the secretion rate de creased to 21.4 ag/ml. Ivo Kunstyr 2373s Zinc transport in ascites tumor cells. Guenther, Th.; Dorn, F. (Zentralinst.. Biochem. Biophys., Freie Univ., Berlin, Ger,). Z. Klin. Chem. Klin. Biochem. 1971, 9(5), 438-42 (Ger). Uptake and release of "Zn by ascites tumor cells are independent of cell metabolism. SH reagents increased the rate of both uptake and release of "Zn. The rate of Zn transport was decreased by incubation at 0 and by changes in pH. Proteins of the cell membrane are probably involved in Zn transport. Accumulation of Zn is attributed to complex formation within the cell. V. N. Nekrassoff 2374t Oncogenic response of rat skin, lungs, and bones to vinyl chloride. Viola, P. A.; Bigotti, A. (Regina Elena Inst. Cancer Res., Rome, Italy). Cancer Res. 1971, 31(5), 516-22 (Eng). Rats exposed for 12 months to vinyl chloride vapors (a const, flow of air contg. 3% vol./vol., 4 hr/day, 5 days/week) developed skin, lung, and bone tumors. The cutaneous system was the most susceptible. 2375u Possible importance of the reading mechanism of DNA in carcinogenesis. Lowdin, P. O. (Dep. Quantum Chem., Uppsala Univ., Uppsala, Swed.). Phys.-Chem. Mech. Carcinog., Froc. Ini. Symp. 1968 (Pub. 1969), 203-7 (Eng). Edited by Bergmann, E, D. Isr. Acad. Sci, Hum.: Jerusalem, Israel. Carcinogenesis may involve damage to the protein (or other) cover of the "closed'' part of the DNA code. Reading the "closed" portion would produce normal proteins, but in the wrong cells, against which immunol. defenses might not operate. Anal. of the proteins of malignant cells is proposed. J. Bunyan 2376v Radioglobulin localization and immunospecificity in the transplanted human choriocarcinoma. Mizejewski, Gerald J. ; Quinones, Jose; Baron, Jennifer (Gen. Med. Res., Veterans Adm. Hosp., Ann Arbor, Mich.). Airier. J, Obslet. Gynecol, 1971, 111(3), 413-18 (Eng). Human choriocarcinoma trans plants in hamster check pouches coiled, both radiolabeled im mune and nonimmune rabbit immunoglobulin G (lgG) as shown by radioautog,, immunofluorescence, and spectrometric anal. The intravascular activity and in vivo immunospecificity of radioglobulin prepns. was shown by using untagged wjjole rabbit sera as blocking agents. Untagged rabbit anti-tiumari chorionic gonadotropin serum could block radio-uptake in' tumor and v vi. it) u i>' S'k, ovary. In contrast, untagged, nonimmune rabbit st) . only tumor radioactivity levels. Both immune and n blocking sera may have satd. IgG receptor sites hi ii,,thus cutting radioglobulm IgG uptake. Possible uu-e! for the tumor's indiscriminate IgG uptake are discussed S. M. M.r 2377w Collagen synthesis in human keloid and hyper' scar. Cohen, I. Kelman; Reiser, Harry R.; S"cr Albert (Exp. Ther, Branch, Natl. Heart Lung lust., ):,i Md.). Surg. Forum 1971, 22 , 488-9 (Eng). Meas'ur- m proline hydroxylase activity (I) in skin correlates well ;- rate of collagen synthesis. This study compares I m hypertrophic scar, and normal skill of humans. In was assayed by incubating minces of skin for 30 min witn prepd. [J/f]-proline labeled protocollagen substrate in tin i : of excess cofactors. Th.e results indicate that the rale , lagen production as measured by I is significantly eh v keloids and hypertrophic scars and partly explains the a he collagen deposition in these states, Sidney V. 2378x Carnosine anserine synthetase of the liver am atoms. Parshin, A. N.; Lebedeva, S. B. (Xauchn'- Inst. Onkol. im. Petrova, Leningrad, USSR). Dok! Nauk SSSR 1971, 200(3), 736-9 [Biochem) (Russ) biosynthesis of carnosine and anserine in the liver of ! mice was compared to that with animals with hepatm.- it was shown that the tumor formation did not affect tl , activity toward carnosine synthesis in any meaningful The work was done with UC tracing of alanine and It- residues. G. M. Kosokr. 2379y Effect of lymphosarcoma on content of sulfhydr- disulfide groups in tumor-bearing animal organs. Darlyi, I.; Novikova, E. N. (USSR). Zdravookhr. Beloruss. No. 6, 47-50 (Russ). From Ref.Zh., Biol. Khim. 1970, No. 19F1290. Content of SH and -S-S-groups in the ' serum decreased gradually in rats with Pliss lympho-ur during tumor development; min. content of SH groups r liver corresponded to their max. content in tumor tissue, tent of SH-groups increased and -S-S-groups decreased m tumor tissue growth. 2380s Stability of chromatographic patterns of amin transfer ribonucleic acid from individual mouse plasmacv * and variability among different immunoglobulin A prod i plasmacytomas and normal organs. Mushinski, J. IV (Lab. Cell. Biol., Natl. Cancer Inst., Bethesda, Md.b chemistry 1971, 10(21), 3917-24 (Eng). The leucyl-, seryt-. tyrosyl-tRNAs from IgA-producing plasmacytomas and n t tissues were compared using reversed-phase chromatog. biol. stability of these chromatog. patterns was establish, ,1 comparing the patterns of these aminoacyl-tRNAs from dub transplant generations of a single tumor line, which were : to be very similar. Confirmation of the concept that patterns reflect a stable population of isoacceptmg specn tRNA comes from the finding that the tRNAs from tw- ferent tumor lines which originated in the same primary n have the same patterns for the three aminoacyl-tRNAs ex.. Four normal tissues examd. in this way showed almost no \ tion in the chromatog. pattern of tyrosyl-tRNA, small differ in leucyl-tRNA, and somewhat greater differences in - tRNA patterns. Four plasma cell tumors which secret'- immunoglobulins with antibody activity showed pattern ferences among themselves which were much more striking the differences among the normal organs. Possible sourc. this variable degree of pattern variation are discussed. 2381t Histidine decarboxylase in the transplantable ar philic gastric carcinoid of Praomys natalensis. Hosoda. Nakamura, W.; Snell, K. C.; Stewart, H. L. (Lab. Pul Aichi Cancer Cent. Res. Inst., Nagoya, Japan). Bim Pharmacol. 1971, 20(10), 2671-6 (Eng). A transplant argyrophilic gastric carcinoid of Praomys natalensis com . appreciable activities of specific histidine decarboxylase aromatic cells, probably histamine-contg. argyropliil cell-. tributed in the gastric mucosa. Specific histidine decarbo- free from aromatic L-amino acid decarboxylase was pm 10-fold by acid plus heat treatment and subsequent (Nit. pptn.; it was not essentially different from that prepd. i other mammalian sources. 2382u Autoradiographic studies on cellular proliferate: vivo of human gastric mucosa in normal and pathologic - ditions, after arterial perfusion of tritiated thymidine. NL moto, Hajime (Second Dep. Pathol., Kyoto Prefect, luiv. . l Kyoto, Japan). Kyoto Furilsu Ika Daigaku Zassin }' 80(7), 399-418 (Japan), Isotonic glucose soln ennu them; lH xvas injected into an artery of gastric cancer paln-ii' injection pressure slightly above the systolic pressure, tne tion of injection was usually about 30 nun, 1 Its- label'11- 1 (LI) was almost equal at any site of the tumor. Thy given for various types of carcinoma. There was no diuerc - LI of gastric carcinoma and metastatic carcinoma m the l> ; nodes. Chronic gastritis was found in noncancerous re around the tumor. \V. K. Kn- OLI 2562 rrr' 107797 Chemical Abstracts Vol. 75. 1971 iST'J hm, loading. Pneumonia, pasteurellosis, and lung hemorrhage were 107804r Histological and histochemical changes in .. obsd. in animals. liver under the effect of the chronic inhalation primh , 107797r Renin level in the kidneys of experimental animals methylstyrene. Lambina, S. A. (USSR). Nauch. Tr ' during chronic poisoning with a mixture of a-methylstyrene and Med. Inst. 1969, No. 88, 190-5 (Russ). Rats were treaV, ` 1,3-butadiene. Serebrcnnikov, 0. A, (USSR). Nauch. Tr., vapors of a-methylstyrene in concns. of 0.005 and o.f). i Omsk. Med. Inst. 1069, No. 88, 244-8 (Russ). The amt. of The inhalation lasted for 4 months at 6 hr/day. A shun renin (I) granules gradually vanished from "epitheloid" cells in of the above treatment resulted in unimportant and fl.... . rats inhaling admissible conens. of the title mixt., but later on I changes in liver parenchyma: fatty hepatic cells, lo'.ut: reappeared. A picture similar to protein dystrophy of the kid glycogen in their cytoplasm, and redistribution of rib. neys developed. D. F. Kalab protein, protein, and sulfhydryl groups. At 1 month th, 107798s Posttoxic reparative regeneration of the liver of rats phol. picture normalized. New changes were obsd. folio.,. . with intact adrenal glands and with corticosteroid deficiency. 2nd month, which were similar to the changes of the i,,,,. , Yakobson, G. S.; Gromova, O. A.; Dobrovol'skaya, S. G.; riod. After 90 days the most significant changes were i Kondakova, A. E.; Nosova, L. V.; Seregina, N. M.; Shorina, the liver. There was no difference in the results fro;;! G. N. (Cent. Sci, Res. Lab., Novosib. Med. Inst,, Novosibirsk, concns. of I except for the time of action. J. G. M USSR). Byull. Eksp. Biol. Med. 1971, 72(7), 95-9 (Russ). 107805s Changes in the secretion of the epithelium of v The livers of adrenalectomized rats with carbon tetrachloride rat trachea and bronchi during the action of a-methvhi-,. poisoning did not show the reparative processes typical of the vapors. Kuz'min, V. I. (USSR). Nauch. Tr., On:U livers of intact rats after CC1< poisoning. Instead, there was a Inst. 1969, No. 88, 209-14 (Russ). Rats were treated ;> greater spread of dystrophy in the liver, a drop in acid RNase, and pors of a-methylstyrene (I) given in a concn. of 0.0b", no change in DNA and RNA or in blood serum fl-globulins. The treatment lasted 6 hr/day 6 tiroes/week for 4 months, 107799t Toxicological study of formamide and its N-methyl ing the chronic intoxication a hypersecretory state deve- and N-ethyl derivatives. Pham Huu Chanh; Nguyen Dat the respiratory tract of the animals. There was a intr.i Xuong; Azum-Gelade, M. C. (Cent. Rech. Toxicites, CNRS, exoceltular accumulation of neutral and acid niueo-sulm, Toulouse, Fr.). Therapie 1971, 26(3), 40D-24 (Fr). The acute such as sialidase-labile sialomucin. The resistance of the r. toxicity of formamides to rats and mice was in the increasing tory organs against damaging factors and influenza viru. order: formamide, TV-methylformamidei jV,Y-dimethylforma- lowered, J. G. 1-W mide, IV-ethylformamide, and N.N-diethylformamide. Mice 107806t Pathomorphologies! and histochemical chan.. . were more susceptible than rats. The compds. induced testicular respiration organs of white rats during the action of o-itK- lesions. Repeated small doses of IV-ethylformamide and N,N- styrene vapors. Kuz'min, V. I. (USSR). Nauch. Tr.. ( dimcthylformamide stimulated the growth, whereas the other Med. Inst. 1969, No. 88, 220-5 (Russ). Rats were treated derivs, were growth inhibitory. All the derivs. given in repeated a-methylstyrene (I) in max. allowable concn, (5.67 mg 1. . doses increased the blood calcium level but depressed the urinary treatment was 6 hr/day for 120 days. In the initial pin excretion of Ca, and the blood levels of potassium and sodium. epithelial portion of the respiratory tract was damaged. II. '5 107800m Toxicity of tissue culture media exposed to poly- secretion of epithelial mucins and damage of permeabm', (vinyl chloride) plastic. DeHaan, Robert L. (Dep. Embryol., blood vessels (in connection with depolymn. of acid mut Carnegie Inst. Washington, Baltimore, Md.). Nature (London), saccharides) were obsd. The max. level of cell reaction cm. Nero Bid. 1971, 231(20), 85-6 (Eng). Blood serum-contg. demonstrated at 60 days, resulting in the accumulation solns. perfused through poly(vinyl chloride) administration mucopolysaccharides of hyaluronic acid and chondroitm :. tubing, of the type used for blood transfusions, became highly type in the connective tissue of the lungs. At the end > toxic to cultured chick embryo heart cells. expt. the new argyrophylic and collagen fibers demonstr.it 107801n Effect of folic acid on deoxyribonucleases in the moderately significant picture of peribronchial and pcm.i > mouse kidney. Temple, K. (Tieraerztl, Fak., Univ. Muenchen, sclerosis. These changes were accompanied by the dam. Munich, Ger.). Z. Naturforsch. B 1971, 26(6), 589-94 (Get). the general structure of pulmonary tissue: focal atclecu-:. < I emphysema. J. G. Fi-ci 107807u Effect of a-methylstyrene on the morphoU. picture of the kidneys of experimental animals. Serebrcw O. A. (USSR). Nauch. Tr., Omsk. Med. Inst. 1969, N- 240-3 (Russ). The expts. were carried out for 120 days- .m The first group was treated every day by vapors of n-nn The effect of i.v. administration of 60-180 mg folic acid (I) on styrene (I) in max. allowable concn. The second grmr the in vitro activity of DNase of the kidney and the DNA and treated at 50% of the above concn. The 3rd group protein content of kidney and thymus of 400 mice was investi control. In the kidneys of exptl. animals changes were gated. About an 80% decrease of renal alkaline DNase (E.C. depending on the dose and intensity of exposure. At t 3.1.4.5) (II) and a 180% increase of an acid DNase (E.C. 3.1.4.5) ginning of the expt. venous hyperemia was obsd. Later er. (III) and of a II inhibitor (IV) were obsd. 2-4 days after injection dystrophy, plasmatic impregnation of vessels, and pern., of high I doses. The protein and DNA content of the thymus sepn, were noted. In the last phase of the treatment di behaved similarly to the II activity of the kidney. The increase tion of parietal cells of Shumlyanskii capsules were obsd. of III in the kidney was due to enzyme induction by I, The ;. g. i-w decrease of II was due to an enzyme loss out of damaged cells 107808v Molecular composition of bones during c1' and to the induction of IV in the kidney. Preliminary studies fluoride poisoning [studied] by an ir-spectroscopic ny- on I-induced damage of the kidney suggest that IV plays a certain Abishev, Kh. A.; Sergaztn, A. G.; Poletaev, E. V : role in combining protein and DNA synthesis by inhibiting II. N. I. (Alma-At. Med. Inst., Alma-Ata, USSR). Zd>. 107802p Morphohistochemical changes in white rat brain Kaz. 1971, 30(5), 28-30 (Russ). Changes in ir absorpi..... during acute poisoning with a-methylstyrene. Zakharchenko, tra of rabbit bones caused by chronic intoxication with V. I. (USSR). Nauch. Tr., Omsk. Med. Inst. 1969, No. 88, studied. Rabbits were given 1.5-4.0 mg NaF per d.n 196-201 (Russ). Different doses (2-3 ml) of a-methylstyrene course of 6 or 12 months. The intoxication with Nal i (I) were given to 10 rats pcrorally in an acute exptl. to investigate about a decrease in the proportion of inorg. substance- > its effect on brain. In the following 1-2 days 9 animals died. bone. The absorption band at 630 cm-1 decreased ami i Diffuse disorders of the neurons of the brain stem were charac 480 cm-1 increased under the influence of NaF treatment-^ teristic. These were not obsd. in the cortex and in the basal nuclei. There were circulatory disorders causing hematomas, I07809W Histological investigations of the effect of m ' edema in the brain material, and increased dystrophic changes of oxides and ozone on some organs of laboratory annum- the neurons, esp. to anoxia-sensitive areas (cortex of the dominant Byczkowski, Stanislaw; Zawistowski, Stanislaw; hrn- hemispheres, diencephalic field etc.), J. G. Fischer Krystyna (Akad. Med., Gdansk, Pol.). Gdansk. To..-. 107803q Specific treatment of acute methyl bromide poison Rozpr. IVydz. 3 1969, No. 6, 101-5 (Pol). Chrome !>t> ing, Mizyukova, I. G.; Bakhishev, G. N. (Uses. Nauchno- of a mixt. of N oxides with Oi in air caused changes m t;' Issled. Inst, Gig. Toksikol. Pestits, Polim, Plast. Mass, Kiev, stitial tissue of the rat lungs. The rats exposed to the >1' USSR). Vrach. Delo 1971, (7), 128-31 (Russ). Cysteine (I) of NOj had changes typical of bronchopneumonia am HSCH,CH(NHj)CO;H 1 trophy of the reticuloendothelial cells of the liver, doses of NOj were as follows; one exposure to j111 " for 3 hr or to 300 mg/m' for 30 min or 3 exposure- in . OLI 2563 was an effective prophylactic and therapeutic agent against abs. each for 3 hr. lethal doses of methyl bromide in rats, mice, ami rabbits when 107810q Carbon-14 dioxide elimination in eip-mn . adnpr.istered orally or s.c. 30 min before or s.c. v. itimi 5 min toxication with carbon tetrachloride following d. 1 -as,>.-- after acute poisoning. I restored the level of sulfhydryl groups (4)-uC administration under aspartate protection, ` '-amd prevented changes in carboxyl and amino groups in the whole Szantay, I.; Tamas, St.; Szabo, Piroska; Cotui, , blood, serum, and protein and nonprotein fractions. I prevented Med. Clin., Cluj, Rom.). Rev. Roum. Biochim. 1 ; the death, paralysis, paresis, and spasms which developed on the 113-16 (Eng). "COt elimination was studied. 3rd-4tli days after MeBr inhalation in untreated animals. following DL-aspartic acid-4-'*C administration m ' * 1 ` 1< ' - -> V x r pee 182 pjge 183 14--Toxicology Vol. 7b, ly/i ' variables Cf., cchllaj nces of '^Rcdfern WaJ, anchimroanlsic, fled. Inst disturbed hi hronjofropic after DO daV!, ascular cui,. >t of poison. !' Kalab 'Ctacarbonvl I- B. (Kiev' Polim. ''plication of oiapliylactjc d is reduced V'. Bezdek 1 of bromoshu Univ. -'o(l), 59-cj he blood of nd the ext. xane-Et-Od tvas then kbits given s increased i was then idmitiistrad level was MK/g even shibashi * change in j | i I ! ! I Jte triphos- Nikulin, i ! Biokkim. n Ref. Zh., n thyroxine rally for 10 respiration esh tissue. _tdministraAp distur. I | i I I I absorpAdmin- w 7-day I horylation la, A. M.; o," Univ. -21 (Ital). -i pressure flow perIn. contc. c. per 100 il arterial satd. with re active, with con- icreases in agnotto Edward HI pp. Order No. l mustard ibson, J. , Mich.), c, 45 and A th; proars, and urves for kg were Tiorphol. treated dt'h dwma from rapidly The ihfI to tlic . unique Ins dur1. Yu.; ftavshanov, T. R,; Kutybaev, Sh.; Akhmcdov, M. (Uzb. .Vauchno-Issled, Inst. Travmatol. Ortop., USSR). Med. Zh. ttf). 1971, (5), 35 (Russ). Chronic intoxication with the in secticide hexachloran (1 mg/kg/day for up to 120 days) de creased the formation of bone callus and delayed the healing of simple lione fractures in expts. with 71 rabbits (2.1-3.5 kg). Therapy with hexachloran antidote normalized the healing pro cess only partly. M. Hava 96889u Biological features of the nematocide Nemagon, and its hyeenic characteristics. Rakhmatullaev, X. N. (Mosk, Med. Inst., Moscow, USSR). Med. Zh. Uzb. 1971, (5), 14-18 (Russ). Chronic administration of Xemagon (0.5-5.0 mg/'kg/- day lor 8 months by mouth) to adult male rats caused pathol, changes in the function of central nervous system, kidneys, and suprarenals, and in hematopoiesis. Morphol. changes were found in the kidneys, liver, and gonads. The min. toxic dose was 0.05 mg/kg/day. The max. allowable conen. proposed is 0.01 mg/1. M. Hava 96890n Toxicological characteristics of Sevin. Muminov, A. I.; Eshkabylov, T. D.; Mukhitdinov, A. G. (Samark. Med. Inst., Samarkand, USSR). Med.-Zh. Uzb. 1971, (5), 18-20 (Russ). Chronic administration of the insecticide Sevin (5 and 50 mg/kg/day by mouth for 6 months) caused pathol. changes in rabbit liver, heart, kidney, lungs, and internal ears. Serum aldolase and alanine transaminase increased after the 1st 40 days according to the amt. of the dose. Doses of 50 mg/kg/day killed 7 rabbits of 18, and doses of 5 mg/kg/day killed 1 rabbit of 18. -M. Hava 96891p Primary toxicological characteristics of Sumithion. Akhmedov, B, K.; Boiko, l. B. (Otd. Pitan., Uzb. N'auchno- Issled. Inst, Sanit. Gig. Profzabol., USSR). Med. Zh. Uzb. 1971, (5), 34 (Russ). Toxicity of the insecticide Sumithion was studied in 36 male rats and 70 male mice. The oral LD in rats was 837.5 mg/kg; in mice 768 mg Teg. The behaviour changes during intoxication are described and are similar to changes evoked by other organophosphates. M. Hava 968Q2q Pathomorphologies! changes in rat organs after administration of threshold doses of monuron and its mixture with atrazine. Xezefi, T. A. (Inst. Epidemiol, Gig., Ashkhabad, USSR). Zdravookhr. Turkm. 1971, 15(1), 8-11 (Russ). The herbicide monuron (40 mg/kg, by gavage) did not cause Clin. symptoms of intoxication, but monuron did cause reversible morphol. changes; damage to the erythrocytes, methemoglobin emia, hypoxemia and resulting changes in the cerebellum. In addn., pathol. changes in the liver, lungs, myocardium, and kidneys occurred. Administration of a mixt. of monuron with atrazine (35 and 25 mg/kg, resp.) resulted in less severe patho- morphol. effects. Maria Lesiak 96893r Unithiol accelerates mercury excretion from birds. Tishkov, A. I. (Vscs. Nauchno-Issled. Inst. Kezaraznykh Bolezn. Zhivotn., USSR). Veterinanya (Moscow) 1971, 47(3), 89-90 (Russ). Unithiol (dimercaprol) (I) injections accelerated Hg excretion from birds. After injection of I, Hg was initially coned, in the liver and kidney while the Hg content in other organs was reduced. With further administration of I Hg was completely eliminated within 45 days. V. Bezdek 96894s Toxicological characteristics of an anthracene- toluene-phenol-formaldehyde resin. Xagornyi. P. A. (Kri- vorozh. Inst. Gig. Tr. Profzabol., Krivoi Rog, USSR). Gig. Primen. Polim. Mater. Izdelii Nikh 1969, Xo. 1, 265-70 (Russ). The title resin has very low toxicity. Long-term oral administra tion may cause pathol. changes in the central nervous system, liver, and kidneys of rats and mice. V. Bezdek 96895t Skin-irritating and allergenic action of fabrics made from polyamide fibers. Ivanova, T. P.; Statsek, X. K. (Vses. Inst. Gig. Toksikol. Pestits,, Polim. Plast. Mass, Kiev, USSR). Gt'g. Primen. Polim. Mater. Izdelii Nikh 1969, Xo. 1, 227-33 (Russ). Water exts. of the polyamide fibers Kapron and Anid cause sensitization and skin-irritating effects in guinea pigs. V. Bezdek 96896u Toxicity of chemical substances isolated from poly- (vinyl chloride) materials. Rapoport, K. A.; Markova, Z. S. (Inst. Obshch. Kominunal'n. Gig. im. Sysina, Moscow, USSR). Gig. Primen. Polim. Mater. Izdelii Nikh 1969, Xo. 1, 222-6 (Russ). Chronic skin application of exts. from poly(vinyl chloride) to guinea pigs and rabbits caused significant leukocy tosis. V. Bezdek 96897v Toxic and teratogenic effects of saturated and un saturated fatty acids on house fly larvae. Quraishi, M. Sayeed (Dcp. Entomol., North Dakota State Univ., Fargo, X. Dak.). J. Peon. Entomol. 1971, 64(4), 787-92 (Eng). Satd. and un- satd, frtty acids interfered with the emergence of adult house flies (Musca domcslica) and wtre toxic when applied to the larvae (0.2 nl). Desatd. fatty acids, a complete series of n- mtsatd. fatty acids contg. 8 to 12 C atoms in the chain and a fratis-2-double bond, and fatty acids with a triple bond in posi tion 2 were investigated. /rans-2-Octenoic acid was the roost toxic, causing 100% mortality at 0.2 ml/larvae. 96898w Differential interaction of aflatoiin B2 with deoxy ribonucleic acids from different sources and with purines and purine nucleosides. Schabort, J. C. (Xatl. Xutr. Res. Inst., Counc. Sci. Ind. Res., Pretoria, S. Afr.). Chr:.-Biol. Interac tions 1971. 3(5), 371-82 (Eng). Aflatoxin Bj (I) was capable oo of weak binding to thermally denatured DXA as well as with highly polymerized yeast and calf-thymus histone. The intar- action of 1 with DXA was dependent on base sequence rather than on base eompn., and a mol. of the toxin was bound to approx. 18 mols. of calf thymus DXA-P. The purine bases and the pres ence of amino groups in the purine mols. probably played an important role in the binding of this toxin to DXA. 96899x Action of atmospheric aldehydic pollutants on the NAD-NADH system of the rat liver, lung, and brain. Ala- bert, Nicole; Godin, Jean; Boudene, Claude; Roussel, Andre (Cent. Rech. Pollut. Atmos., Inst. Xatl. Sante Rech. Med., Le Vesinet. Fr.). C. R. Acad. Sci., Ser. D 1971, 272(26), 3363-6 (Fr). Exposure of rats to the atmospheric pollutants acrolein, formaldehyde, and acetaldehyde in conens, of 90, 140, and 10,000 em'/m', resp., for 3 hr, modified the NAD and XADH levels in various tissues. Acrolein depressed the NAD+ levels in the liver, lung, and encephalon and increased the XADH levels in the fiver and encephalon. HjCO depressed in the encephalon the NAD* level very markedly, and the XADH slightly. AcH increased the NAD* levels and depressed the XADH levels in the liver and lung. 96900r Morphological changes in white rat testicles during the action of a-methylstyrene and 1,3-butadiene vapors on the animals. Morozov, G. 1. (USSR). Nauch. Tr., Omsk. Med. Inst. 1969, Xo. 88, 249-53 (Russ). a-Methylstyrene (I) dis turbed permeability of veins in that blood proteins accumulated in their walls and the stroma of testicles. Spermatogenesis was inhibited and dystrophic and necrotic changes finally developed. There were, however, signs of adaptation to I. Restoration of spermatogenesis after 60-90 day treatment with I took >24 days. The title mixt. showed the same effects as I alone, D. F. Kalab 96901s Histochemical study of nucleoproteins, amino acids, and functional groups of protein molecules during experimental poisoning by cracking gas. Lyutikova, T. M. (USSR). Nauch. Tr., Omsk. Med. Inst. 1969, Xo, 88, 274-81 (Russ). Rats (200) inhaled cracking gas (0.01 and 0.003 mg/l., expressed as H-S) 6 hr a day for up to 120 days. Histochem. changes in the central nervous system were due to disturbances of intracellular processes. A severe decrease of SH groups was obsd. in neurons of the motor and thalamic regions of cerebral cortex. Redistribu tion of protein SH groups probably depended on cellular en zymes, the activity of which is controlled by the presence of SH groups. Changes in carboxyl groups (mainly glutamine) indi cated that detoxication of NHj was disturbed. D, F. Kalab 96902t Morphological changes in the internal sex organs of female white rata during the action of vapors of a-methyl- styrene alone and mixed with 1,3-butadiene on the ammals. Morozov, G. I. (USSR). Nauch. Tr., Omsk. Med. Inst. 1969, Xo. 88, 254-60 (Russ). During the 1st month of poisoning fe male rats with the title mixt., the no. of primordial and maturing follicles decreased. Large nos. of corpus luteum were preserved and their luteinizing cells contained numerous RXA granules and large particles of glycoproteins indicating that these cells were functioning and active. The nos. of eosinophils in the mucous membrane of uterus and pyroninophils in stroma increased some what. After 2-3 months, signs of adaptation to poisoning ap peared, D. F. Kalab 96903U Effect of the long-term action of small concentrations of a-methylstyrene alone and in a mixture with 1,3-butadiene on the cholesterol level in the serum of animals. Chnkreev, E, F. (USSR). Nauch. Tr., Omsk. Med. Inst. 1969, Xo. 88. 261-4 (Russ). Poisoning with the title mixt. or a-methylstyrene alone for 120 days increased the cholesterol contents in blood of 84 rats, particularly cholesterol esters (from 29,3 to 64.9 mg %). D. F. Kalab 96904V Accelerated elimination of methyl mercury from animals. Takahashi, Hitoshi; Hirayama, Kuniko (Med. Sch., Kumamoto Univ., Kumamoto, Japan). Nature (London) 1971, 232(5307), 201-2 (Eng), Continuous oral administration of reduced human hair powder decreased the level of residual methyl mercury in mice poisoned with methyl mercuric chloride, indicating that methyl mercury (I) excreted into mtcstii't* was eliminated by this procedure in the feces. Reabsorption of I ex creted into bile may be 1 of the reasons for the prolonged biol. half-life of I in the animal and any material that has I binding ca pacity is resistant to digestion and absorption from the intestine may be useful for eliminating I from animals. Synthetic rc-rns with SH groups may be effective for the same purpose. The procedure may be useful in cases of accidental ingestion of- org. 7~ 9*>m OLI 2564 123241 Chemical Abstracts Vol. 74, 1971 s% Page 282 other fractions. Unlike CC1, intoxication, P intoxication in creased the activity of glucose-0-phosphatase. All of these re sults may help to explain the differences and similarities between CCli and white P poisoning. DZJN 123241q Histochemical study of the "adrenocortical lipid hyperplasia" induced in rats by aniline. Horvath, Eva; Ko- vacs, Kalman; Yeghiayan, E. (Inst. Med. Exp. Surg., Univ. Montreal, Montreal, Que.) Acta Histochcm. 1971, 39(1), 154- el (Eng). S.c. administration of 30 mg aniline (I) to rats for 7 or 14 days caused adrenal enlargement, increased the amts, of sudanophilic lipids and cholesterol, but decreased the activities of succinic dehydrogenase, lactic acid dehydrogenase, and steroid- 3ff-ol dehydrogenase. I probably interferes with corticosteroido- genesis at the adrenal level. - FGJN 123242r Gossypol: subcellular localization and stimulation of rat liver microsomal oxidases. Abou-Donia, Mohamed B.; Dieckert, Julius W. (Dcp. Biochem. Biophys., Texas A and M Univ., College Station, Tex.) Toxical. Appl. Pharmacol. 1971, 18(3), 507-16 (Erg). In rats, although the level of gossypol (I) ci--N CMMfj OHMti after oral administration was not exclusively segregated in any 1 liver cell fraction, most of it was found in the microsomal frac tion. I was distributed according to its lipid-sol. property rather than by virtue of its reaction with protein. In rats fed , I, the liver microsomal enzyme which catalyzed the oxidative demethylation of p-chloro-A'-methylaniline-HCl (II) increased in activity. A no effect dosage for the stimulation of demethylation of II by dietary gossypol was 50 mg/kg. The I stimulation of rat liver microsomal oxidases seems to be due to an increase in enzyme synthesis since it did not alter the K. (6.7 X 10"*Af) but increased the max. velocity of I demethylation (33%). The ability of rat liver microsomal enzymes to dealkylate some car bamate pesticides was increased by the oral administration of I. DCJN 123243s Exploratory study of automobile driving perform ance under the influence of low levels of carboxyhemoglobin. Ray, A. M.; Rockwell, T. H. (Dep. Ind. Eng., Ohio State Univ., Columbus, Ohio). Ann. N.Y. Acad. Sci. 1970, 174(Art. 1), 396-408 (Eng). Estd. automobile conens. of CO result in 8% of the nonsmokers having blood carboxyhemoglobin concn. levels greater than 7% and 4% having greater than 14% car boxyhemoglobin, assuming that they were exposed for two hr or more. Smokers would have carboxyhemoglobin levels up to 15% higher than these depending on their smoking habits. Several of the effects of carboxyhemoglobin were definitely detrimental to driving performance. Harry W. Gordon 123244t Effect of carbon monoxide on human performance. Mikulka, Peter; O'Donnell, Robert; Heinig, Patrick; Theo dore, James (Old Dominion Univ., Norfolk, Va.). Ann. N.Y. Acad. Set. 1970, 174(Art. 1), 409-20 (Eng). A study was under taken to det. the effects of CO on relatively simple applied per formance tasks. Carboxyhemoglobin (COHb) levels reflected a direct relation with the ambient CO exposure levels. The in dividual performance curves revealed no consistent differences as a function of low levels of CO exposure. Harry W. Gordon 123245u Human performance of a psychomotor test as a function of exposure to carbon monoxide. Hanks, Thrift G. (Syst. Corp., Newport Beach, Calif.). Ann. N.Y. Acad. Sci. 1970, 174(Art. 1), 421-4 (Eng). No effect on performance of the crit. tracking task of Jex (1966) attributable to CO exposure was found. An empirical relation wasobsd. between pulmonary CO and blood carboxyhemoglobin values. Harry W. Gordon 123246v Chemical poisoning. Hoogendoorn, D. (Sticht. Med. Reg., Utrecht, Neth.). Ned. Tijdschr. Cenecsk. 1970, 114(39), 1644-5 (Neth). Statistics were gathered in the Nether lands on poisoning by chem. compds. other than compds. for medical use. Poisoning by CO was the roost frequent type dur ing the period 1967-68. The largest no. of poisonings were en countered in the 1-4 age group. They were principally due to petroleum products ami industrial solvents. A. G. Derouane 123247w Disintegration products and smoke generation from fire action on plastics. 1. Rumberg, Eckhard (Staatl. Mate- rialpruefungsamt. Nordrheim-W'estfalen, Dortmund-Aplerbcck, Ger.) VDI (Ver. Dcul. Ing.) Z. 1971, 113(1), 20-4 (Ger). The toxicity and irritating effects of smoke and products of the thermal degradation of plastics on rats were studied. The possible detn. of relative toxicity of these combustion gases is also discussed. The toxic effects of gaseous pyrolysis products of polyolefins, poly (vinyl chloride) (PYC), polystyrene, polyacry lonitrile, polymethacrylates, and other synthetic polymers were studied on animals and humans. At 2-300, these polymers gave off gases which were less toxic to rats than those ntwrinrl nr rustier TVC (.`OBlBUSlibh gases WETS fh'e"ifnost toxic of the synthetic plastic decompn. products tested. BFJG 123248X Toxicity of bilirubin. Beck, Kurt (Gastroenterol. Abt., Med. Univcrsitaetsklin., Freiburg/Br., Ger.). Dcul. Z, Verdau. Stoffwcchselkr. 1970, 30(1-2), 47-51 (Ger). The i.v. LD of bilirubin (I) in rats is ~150 mg/kg. The animals be come atactic and die in tonic convulsions. Increased serum transaminase values, necrosis of liver and myocardium, severe renal tubular damage, and marked hemolysis with hcraoglobi- nemia and hemoglobinuria were obsd. By inhibiting respiration and decoupling of oxidative phosphorylation, I blocks its own detoxication, which depends on normal oxidn. and intact oxida tive phosphorylation. The toxicity of I is higher in adrenal- ectomized animals, which is partly due to glycogen depletion in the liver. This increase of toxicity is partly prevented by pre treatment with synthetic glucocorticoids. Kurt H. Zingraf 123249? Lead poisoning in cattle; brain lesions and hema tologic changes. Christian, R. G.; Tryphonas, L. (West. Coll. Vet. Med., Univ. Saskatchewan, Saskatoon, Sask.). Amer. J. Vet. Res. 1971, 32(2), 203-16 (Eng). In cattle with Pb poisoning, diagnosed initially by ciin. and toxicol. observa tions, gross brain lesions consisting of cerebrocortical softening, yellowish discoloration, and cavitation, were obsd. only in those with prolonged din. illness (>9 days), being most severe in the occipital lobes, but the tips of most cerebral gyri were affected. In acute Pb poisoning, microscopic lesions varied from diffuse capillary activation to scattered focal areas of status spongiosis and necrosis of the cerebral cortex. In subacute and chronic poisoning, the microscopic lesions were located at the gyral tips and ranged from different degrees of status spongiosis, astrocytic swelling, and nerve cell degeneration to severe cavitation and vascular proliferation. Exptl. induced Pb poisoning in 3 2-year old cattle produced acute, subacute, and chronic syndromes with clin. and pathol. features similar to those obsd. in naturally occurring Pb poisoning. David B. Sabine 123250s Intraerythrocytic 2,3-diphosphoglycerate and carbon monoxide exposure. Astrup, Poul (Dep. Clin. Chem., Rigs- hosp., Copenhagen, Den.). Ann. N.Y. Acad. Sci. 1970, 174 (Art. 1), 252-4 (Eng). 2,3-Diphosphogiycerate concns. were measured in the blood after 24 hr exposure of normal individuals to CO, leading to approx. 20% carboxyhemoglobin. The results indicated an 8% fall in 2,3-diphosphoglycerate, resulting in a higher affinity of Hb for O and a displacement of the oxyhemo globin dissocn. curve to the left. The same thing occurred when the percentage of reduced Hb was diminished by exposing pa tients to O inhalations or high atm. pressure (2 atm). Harry W. Gordon 123251t Effects of elevated carboxyhemoglobin on gas ex change tn the lung. Brody, Jerome S.; Coburn, Ronald F. (Sch. Med., Univ. Pennsylvania, Philadelphia, Pa.). Ann. N.Y. Acad. Sci. 1970, 174(Art. 1), 255-60 (Eng). Small amts, of CO directly interfere with alveolar gas exchange. The tissue hypoxia produced by CO inhalation may be accentuated by rather marked degrees of arterial hypoxemia in patients with heart or lung disease. The arterial hypoxemia in these instances results from the CO-induced changes in the shape of the oxyhemo globin dissocn. curve. Harry W. Gordon 123252U State of the biliary tract of pilots and technicians working with chemical poisons. Kaskevich, L. M. (Klin. Otd., Vses. Nauchno-Issled. Inst. Gig. Toksikol. Pestits., Polim. Plast. Mass, Kiev, USSR). Vrach. Delo 1971, (1), 133-6 (Russ). A group of 102 pilots and 30 air technicians working with chem. poisons of the chlor- and phosphoorg. group was compared with a group of 104 pilots and 11 air technicians not exposed to the poisons with respect to their biliary functions. A higher frequency of biliary tract diseases was found in the ex posed group and often chronic cholecystoangiocholitis had a latent course. Duodenal probing is recommended to ensure early diagnosis, and prophylactic hygiene is suggested. M. Hava 123253V Cannabis: study of the fractional extracts of the cannabis plant, smoke of cannabis cigarets, and residues in the urine of cannabis cigaret smokers. Repetto, M. J-; Menden- dez, M. (Inst. Natl, Toxicol., Seville, Spain). J. Ear. Toxicol. 1970, 3(6), 392-6 (Fr). Thin-layer chromatog., uv spectro photometry, and gas chromatog. of cannabis (hemp) plant exts., cannabis smoke and pipe residues, and urine of cannabis smokers was carried out. The detection of cannabis components was possible in all of these sources. Detection in urine was carried out by gas chromatog. using an SE-30 column on Chroinosorb after extn. with hexane and washing the ext. with XaCl soln. r - Kurt H. Zingraf * L23254w Effects of essential phospholipids (EPL) on the iip'd contents of the serum and liver in white rats after a single dose of ethyl alcohol. Samochowiec, Leonidas; Wojeicki, Jer*y (Dep. Pharmacol., Pomeranian Med. Acad., Szczecin, lo.) J. Med. (Basel) 1970, 1(5), 299-303 (Eng). The increased amts. OLI 2565 71 14--Toxicology Vol. 7< 1971 6 , 74465 vcnrs of age, who died with ale. in their blood, were ana. ' |,,r EtOH, and the contents in blood, brain, lungs, and liver ' utuilatcd for each individual. Typical resp. EtOH perwere 1-05, 1.57, 0.65, and 1.4; 3.64, 3.G4, 1.17, and . ami 1.1, 1-4, 1.2, and 1.2, resp. This indicates uneven V.Vauion of EtC>H in the human body. D. F. Kalab ' ut'ly Toxicity and reproduction studies of cefaioiin in story animals. Watanabe, Nobuo; Iwanami, Koki; ,v, Toiliiyuki (Res. Lab., Fujisawa Pharm. Co., Ltd., Osaka, Nippon Kagaku Ryohogakvkai Zassln 1070, IS(5j' ; > 13 (Japan). Na eefazolin (I) with a mouse i.p, LD of [ NCM2C0M COtNO 1 , ' r Vg, had no teratogenic effects in exptl. animals, but ex- i !urd lower renal toxicity in rabbits than did cephaloridine. t .'0 mg/kg). when given s.c. for 3 months to dogs, caused jrtvrrliagc at the site of injectiou, which was accompanied by j-wmia, loss of albumin, and by hypererythropoiesis in the :n and bone marrow. When given i.v. for 1 month, I was 4M,iid of such toxic effects. FKJY 14453* Toxicity of trimethylene glycol for the chick. Creek, gsturd D. (Dep. Poultry Sci., Univ. Maryland, College Park, \U.), Poultry Sci. 1970, 49(6), 1086-7 (Eng). Chicks given MOCHjCHjCHjCW , ,i;ct contg. 10% trimethylene glycol (I) showed extremely poor tiuwih. but no other abnormalities were obsd. BQJN 74454a Possible mechanism of liver necrosis caused by aro- caiic organic compounds. Brodie, Bernard B.; Reid, Watson (i ; Cho, Arthur K.; Sipes, Glenn: Krishna, Gopal; Gillette, lnr.es R. (Natl. Heart Lung Inst., Natl. Inst. Health, Bethesda, bit). Proc. Not. Acad. Sci. U.S. 1971, 68(1), 160-4 (Eng). 0I Treatment of rats with phenobarbital (I) (80 mg/kg i.p.), which xmiulates the activity of the drug-metabolizing enzymes in the tier, potentiates hepatic necrosis elicited by bromobenzene and niter halogenated aromatic compds. such as 1,2-dibromoben- mt, iodobenzene, and fl-chloronaphthalene. Radioautographic Judies indicate that UC labeled bromobenzene (0.13 mi/30 g, p.) was covalently bound at the sites of necrosis, inferring that .be hcpatotoxic effects of the halogenated aromatic hydrocarbons i:e mediated by them, active metabolites formed in hepatocytes. C.'orobenzene, 1,3 dichlorobenzene, and o-chloronaphthalene re converted by 1-treated liver microsomes in vitro to active mtrmediates which formed covalent complexes with MS-labeled Jlutathione. FGJN 74455b Effects of hyperbaric oxygenation on metabolism. VII. Succinate protection against oxygen toxicity in large ani- rnls. Currie, William D.; Kramer, Richard S ; Sanders, t-Jmn p (Dep. Radiol., Duke Univ. Med. Cent., Durham, C.j. Proc. Soc. Exp. Biol. Afed. 1971, 136(2), 630-1 (Eng). '* succinate (8 mAf/kg/hr for 50 min prior to and during ex- :*oure to 100% O at a pressure of 4Q psig) protected dogs against t' perhiric oxygen-induced convulsions. The relatively large 'l0** were satisfactorily tolerated by the large animals in- bating that Na succinate may be useful as a protective agent ' . humans undergoing hyperbaric O treatment. BSJN '4456c Hematological variations in rabbits submitted to mbseute intoxication with sodium nitrite. Fratoni, Alma; C. A.; Miuccio, C. F.; Violante, A. (1st Naz. Nutr., mv. Roma, Rome, Italy). Quad. Scali'o Diagn. Clin. Lab. '*0 6(2), 325-30 (Ital). NaNOi (5-30 tig/kg) administration [" Cubits i.p. for 5-10 days caused a significant decrease in eryth- *>'(es and an increase in methemoglobin. A high degree of vmia was obsd. in all rabbits except for those treated with the " dose. No significant variation was found in the no. of *'"Jt'*'yte51 nor in the osmotic resistance of the erythrocytes, and " hilirubinemic rate A slight decrease in Hb was also ob- V/'1- Carlo Bauer '4457d Enzymic variations of erythrocytes in rabbits sub- to subacute intoxication by sodium nitrite, Di Felice, r,: ', .Uma; Terzani, G.; Violante, A. (1st. Xn-. Nutr., ' Kama, Rome, Italy). Quad. Sclavo Diagn. Clin. Lab. i.',. 1 b'-), 331-9 (Ital). The activities ol different enzymes _.1 l!,,td. in the erythrocytes of rabbits made anemic by daily .'"-'Tal NaNOj injections at doses of 5 and 10 mg/kg body wt. ' .V1' "os a clear decrease in pyruvate kinase and lactate de- ^-'ogenase at both doses. Glucose-6-phosphate dehydrogenase with 10 mg/kg and decreased with 5 mg/kg, this ap- < h lscorclance was attributed to the more severe anemia at mglicr dose. An increase was also noted in aldolase and transaminases. The decrease of pyruvate kinase explained the increase in methemoglobin via a decrease in NAD-dependent methemoglobin reductases <diaphorases). Carlo Bauer 7445Se Enzymic activities in blood serum of rabbits treated with sodium nitrite. Di Felice, A.; Fratoni, Alma; Galante, A.; Violante, A. (1st. Naz. Nutr., Univ, Roma, Rome, Italy). Quad. Sda'.-o Diagn. Clin, Lab. 1970, 0(2), 340-5 (Ital). Serum enzyme levels were detd. in rabbits treated with NaXOi. An increase was noted in pyruvate kinase, lactate dehydrogenase, alk. phosphatase, and transaminases for 10 days. Glucose-G- phosphate dehydrogenase, aldolase, and transaminases after 10 days decreased. Lesions in some tissues were related to the above variations. Carlo Bauer 74459f Adrenal cortex dysfunction during subacute intoxi cation by sodium nitrite in rabbits Violante, A ; Fratoni, Alma; Cianetti, A. (1st. Naz. Nutr , Univ. Roma, Rome, Italy). Quad. Sclato Diagn. Clin. Lab. 1970, 6(2), 346-50 (Ital). Considering the subacute toxic effects obsd. in rabbits treated with NaNOa, a serious suprarenal insufficiency was as sumed as the main reason of their death. The degree of adrenal cortex dysfunction was investigated through the levels of uri nary 17-keto steroids and 17 ketogenic steroids; a sharp decrease in these steroids was obsd. G. De Stefanis 74460z Lipid composition of RBC [red-blood-cell| ghosts, liver mitochondria, ana microsomes of ethanol-fed rats. French, Samuel W.; Ihrig, Thomas J.; Morin, Robert J. (Sch. Med., Univ. California, Torrance, Calif.). Quart. J. Stud. Ale., Part A 1970, 31(4), 801-9 (Eng). Lipids in liver mitochondria and microsomes after 13 weeks and in KBC ghosts after 25 weeks re mained uneffected in rats fed 30% EtOH with an adequate diet. Mitochondrial phospholipid was reduced after 22 weeks. EtOH ingestion for 14 weeks increased some mitochondrial fatty acids and decreased others, but microsomal fatty acids were un changed. Harry W. Gordon 74461a Effects of ethanol on membrane lipids. Incorpora tion of palmitate-l-uC into microsomal and mitochondrial lipids in mouse liver. Ferrell, William J.; Miceli, Joseph N. (Bio- chem. Div., Univ. Detroit, Detroit, Mich.). Quart. J. Stud. Ale., Part A 1970, 31(4), 810-15 (Eng). Incorporation of pal- mitate-I-14C into total lipids of mouse-liver microsomes and mito chondria was reduced in vivo when mice were fed increasing COTicns. of EtOH. An increased enzymatic hydrolysis of phos pholipids or a decreased synthesis is suggested. Harry W. Gordon 74462b Comparative study of biochemical and morphological lesions of the liver of rats treated with tetrachloromethane and bromotrichloromethane. Calligaro, A.; Congiu, L.; Vannini, V. (1st. Fatol. Gen., Univ. Cagliari, Cagliari, Italy). Rass. Med. Sarda 1970, 73(4), 365-77 (Ital). The toxicities of Br- CljC and CCU were studied. BrCliC was more toxic then CC1,. Felix Saunders 74463c Effect of poiy(vinyI chloride) (PVC) dust on the re- spiratory system of the rat. Popow, Jerzy (Akad. Med., Bialy- stok, Pol.), Rocz. Akad. Med. Bialymstoku 1969, (Suppl. 24), 5--48 (Pol), Wistar rats (60) were placed for 1 hr a day in a PVC atm. contg. 92% particles of diam. <5 u. The time of treatment varied in different groups from 1 to 12 months, after which sections of lungs were examd. PVC dust proved to be biol. active with mech. and toxic effect on the respiratory sys tem. Irena Kloczko 74464d Proof of poisoning with belloid and bellasponum (bellataminolum) during chemico-toxicological analysis. Lozo- vaya G. F. (Mosk. Med. Inst. im. Sechenova, Moscow, USSR). Sud. Med. Ekspertisa 1970, 13(4), 31-6 (Russ). Neonal, pheno barbital, atropine, ergotoxine, and ergotamine were detd. in Belloid and Bellaspon tablets using thin layer chromatog. with CHClj-EtOH-25% NH4OH (20:5:1). The tablets dissolved in HiO or liver tissue to which the tablets were added were extd. with CHCti at pH 2.0. The aq. layer was made alk. to pH 10-11 and extd. with CHClj. Barbiturates were detected by the reaction with diphenylcarbazone and HgSO< or by micro- crystn. reaction with KI in the eluate. Alkaloids were detected in uv light, by spraying with Lugol soln., and by other classical reagents. The barbiturates were also detd. in organs of rabbits given orally Belloid or Bellaspon tablets with the barbiturate content in the range 500-1200 mg. The sensitivity of the method is 0.5 mg Neonal, 1 mg phenobarbital, 0.3 mg ergot alka loids, and 0.2 mg atropine. Peter Skrabanek 74465e Phenobarbital and deiamethasone inhibition of the adrenocortical response of rats to toxic chemicals and other stresses. Szot R. J.; Murphy, Sheldon Douglas (Dep. Phys iol. , Harvard Sch. Public Health, Boston, Mass.). Toxicol. Appl. Pharmacol. 1970, 17(3), 761-73 (Eng). Plasma and \f /' OLI 2566 adrenal corticosterone (I) levels in male rats increased 2--4-fold --r ej - iff, * ------- W-, ------ft ,,. 14--Toxicology Vol. 73, 1970 aanfifWtiafrnfVi <rh |IL /- 85994 . and in cardiac, renal, and lung tnorphol. The ' ,|f'tl max. permissible conen. was 0.3 mg of Sb/mJ if ' John Howe Scott Influence of cadmium compounds on the generative Tsvetkova, R. P. (Med. Inst. im. Sechenova, Mos- ^p)' Gig. Tr. Prof. Zabol. 1970, 14(3), 31-3 (Russ). V produced by various Cd compds. on the generative j()0 females working with alkali storage batteries and j.-eiits contg. Cd and Zn was studied. The women were i,, ihc edcct of Cd compds. in concns, of 0.03-35 mg/m1. . nens. do not affect the menstrual cycle, the course of ' and term of delivery. However, the wt. of children these females differed significantly from that of neonates . - females. Expts. on rats divulged the functional , '. ,. GISOi on the estrous cycle in females. The wt. of preg- mules exposed to the action of CdSO< and the wt, of new- /. ,/(, were significantly below that in control animals. The " . f m-wborn rats born to exposed female rats contained 2.5 , - j, much Cd as those of the control animals. Within 3 .. afk-r delivery 7% of control animals and 26% of treated ,,!, After 7 months' exposure to Cd the wts. of the preg- and control animals were not different. G.Muacevic i-.Vb Action of the polycyclic aromatic hydrocarbon 3,4- ;-.rcne on isolated mitochondria of normal and tumor cells. -Lova, N. A.; Petrikevich, S. B. (Inst. Chem. Xatur. Moscow, USSR). Itr. Akad. Nauk SSSR, Ser. Biot. - ft, 018-20 (Russ). Respiration of rat liver mitochondria . m.ciuate was markedly inhibited by 3,4-bcnzopyrene when .. ,-utvd for 15 min at 26 in the dark, and even more so when %ikd by long-wave uv light. Only a slight effect of 3,4- - ; ; viene was obsd. under similar conditions with mitochon- . i :t m Jensen sarcoma, presumably due to disturbances in the . mme system. Petr Skrabanek t'vUe Selenium. Hogue, Douglas E. (Dep. of Anim. Sci., ,-^il l/niv., Ithaca, N.Y.). J. Dairy Sci. 1970, 53(8), 1135-7 i i . Sc toxicity and deficiency in animals is reviewed with 27 BCJN f iMd Accumulation of manganese in rats during experi- fal manganese intoxication. Boyadzhiev, V.; Khalacheva, iv-iev, I. (Hop. Yama, Varna, Bulg.). /. Eur. Toxicol. : ,4), 212-15 (Er). The distribution of Mn in various ~ of rats given 100 mg Mn!t (soln, of MnCls)/kg orally, - "i uilier day for 60 days, was examd. In control animals, the *"i ronen. of Mn was found in the adrenals; brain, liver, blood, and parietal bone followed in this order. Exptl. ' :. ^ning increased the concn. in all tissues, but it was highest '-- 3 and brain and lowest in liver. A correlation existed the accumulation of Mn and the duration of poisoning. Kurt H. Zingraf ' 5e Effect of alpha naphthyl isothiocyanate on the liver of ' wj and calves. Gopinath, C.; Ford, E. J. H. (Dep. Yet. Mud., Univ. Liverpool, Liverpool, Engl.). J. Pathol. 1W(4), 269-80 (Eng). a-Naphthyl isothiocyanate 1 <100,400, or 000 mg/kg, intragastricaliy) increased both juw ATPase activity around the canaliculi and the sinus- X'k. phosphatase activity, and decreased glutamate dehy- succinic tetrazolium reductase, and esterase activity ' ami sheep livers. In the serum, sorbitol dehydrogenase, ' He dehydrogenase, and arginase activity increased, ' "ii concn. increased, and Bromsulphthalein clearance *<(1 following AXTT administration. Hepatic periportal ' -''ed swelling, vacuolation, and loss of paniculate staining. * "j- to the above changes, chronic administration of ANIT 1'Ki mg/kg/day) decreased the albumin-to-globulin ratio P.isnia and caused intravascular red ceil breakdown. i ' ^le of gastrointestinal absorption of kerosene in pro- " t pneumonitis in dogs, Wolfe, Bruce M-; Brodeur, Shields, J. B. (Sch. of Med., St. Louis LTniv,, St. - / Pediat. 1970, 76(6), 867-73 (Eng). After * "as injected directly into the stomachs of 7 pups, none - ... , i:l,,na!s had any radio!, evidence of pneumonitis, while . ., 'i 5 f the 7 had histol. suggestions of edema. One had i ^mon-hage. DCJN ' Solar simulator sunscreen evaluations in guinea pigs. ........ . Martin, Garland X.; Pu-ohuta. H.; Hockett. " '.m, Margaret M. (Smith Kline .md Freuui Lid., i' tan.). J. bur. Cosmct. Chan. 1979, 21'S), 607-12 , '' ht sunscreen preptis. contg. such active ingredients as ' '`'Mimethylarmnobenzoate, homomenthyl salicylate, '"obonioic acid, were evaluated on guinea pigs with 1 need erythema both with and without washing after *, tin the nonxvashed site, most of the sunscreens . from irradn. ranging from 1 min. erythemal dose |7 yff'-D's. When sunscreen sites were rinsed with .1 y tt'Ottmyl-p-A'.A'-dimethylaminobcnzoate in 75% -1 "r hydrnalc. lotion with emollients and p-aminobenzoic . w , o .f 85988h Pathology of vinyl chloride. Viola, P. Luigi (1st. Patol. Gen., Univ. Perugia, Perugia, Italy). Med. Lav. 1970, 61(3), 174-80 (Eng). Twenty-five rats after being exposed to vapors of vinyl chloride (30,000 ppm) 4 hr/day 5 days a week for 12 mouths were sacrificed in lots at 20-day intervals. After 10 months some animals showed a decrease in wt. and aggressiveness to outside stimuli and disturbed equil. Thirteen animals died from cardiorespiratory complications. Two animals died from hematoperitoneum. Most of the animals showed pathol. de generation of the brain, liver, kidneys, and thyroid. Six rats showed histopathol. alterations of the skeleton. Degeneration of the skeleton and connective tissue was similar to that observed in human acroosteolysis of the hands. L- D. Pagnotto 85989] Pathomorphological changes in the lungs during experiments involving boron carbide and corundum dust. Bronshtein, I. P.; Danilova, R. 1. (Uzb. Nauch.-Issled. Inst. Sanit., Gig. Profzabol., USSR). Med. Zh. Uzb. 1969, (12), 40-2 (Russ). Male rats (1.5 month old) were given boron carbide and corundum dust intratracheally in a dose of 50 mg/ml of physiol, saline. The dust of various dispersions contained about 90% AUO). The animals were killed after 3, 6, 9, and 12 months. Intoxication with dust resulted in inflammatory processes with peribronchial and perivascular sclerosis. Some animals had catarrhal pneumonia. The permeability of the arterial wall increased and dystrophy of connective tissue, caused by destruc tion of the procollagen complex, caused reticular pneumosclerosis. M. Slavikova 85990c Embryotoxic actions of trypan blue in mice in relation to the time of administration. Schluetcr, G. (Inst. Toxikol., Farbenfabriken Bayer A.-G., Wuppertal-Elberfcld, Ger.), Naunyn-Schmiedcberg) Arch. Pharmakol. 1970, 267(1), 20-30 (Ger). Mice received 1 s.c. injection of trypan blue (100 mg/kg) at days 6-14 of pregnancy. Injection at day 8 caused highest percentages of resorptions or malformations (notably exen- cephaly). Injection at days 8 to 14 cause growth retardation. J. Dufrenoy 8599Id Production of atherosclerosis in lathyritic aortas of rats. Hosoda, Yasuliiro; Suzuki, Minoru (Dep. of Pathol., Baylor Coll, of Med., Houston, Tex.). Pathol. Microbiol. 1970, 35(4), 267-79 (Eng). Weanling male rats receiving fi-aminopro- pionitrile fumarate (BAPX') (0.4%) for 3 weeks, and fed an atherogenic diet supplemented with 0.2% BAPX" for 4 weeks, and with 0.1% BAPX' for 9 weeks exhibited gross intimal lipidosis of the aorta in as early as 3 weeks. Dissected spaces of the aorta were filled with proliferating medial cells, and in the subendothelial zone, the smooth muscle cells were mixed with lipid-laden macrophages. Between the test and control animals, none of the major serum lipid fractions were significantly different, thus indicating that lathyritic changes of rat aortas induce not only active repair of damaged media but also enhance intimal lipid deposition. CGJXT 85992e Histological and histochemical pattern of the testes of rats exposed to carbon disulfide. Gondztk, Marian (Pomorska Akad. Med., Szczecin, Poland). Patol. Pol. 1970, 21(2), 129-36 (Pol), In rats poisoned by i.p. administration of CSi (12.5 or 25 mg/kg every other day for 60-120 days), regressive, degenerative, and atrophic changes were obsd. in the spermatogenic epithelium and interstitial tissue when the 25 mg/kg dose was given for more than 60 days. Irreversibility of the changes was postulated. Jerzy Lange 85993f Pathogenesis of asbestosis. Szymczykiewicz, Kon rad (Dep. Aerosols, Inst. Ind. Med., Lodz, Poland). Pol. Med. Sci. Hist. Bull. 1970, 13(3), 115-19, 138 (Eng). The cryst. structure of chrysotile asbestos (I) and quartz is responsible for their similar noxious biol. activities. Cryst. I caused pulmonary changes in guinea pigs characteristics for asbestosis wnereas amorphous I did not. Cryst. I and quartz significantly increased the O consumption of lung sections of white mice and the y globulin fraction of rabbit blood serum compared with controls, amorphous I, coal dust, fiber glass, and (or) fine glass. Textile asbestos factory workers in the spinning and weaving depts , which have higher concns. of longer fibers, have a higher incidence of asbestosis than workers in preparatory depts., where the dust concn. is highest. BCJX 85994g inhibition of the acute ethanol-induced fatty liver by pyrazole. Morgan, J. C.; De Luzio, X'icholas R. (Sch. of Med., Tulane Univ., X'--v. Orleans, La.). Proc. Soc. Ero. Bitti. Med. 1970, 134i2), 462-fi (Eng). Since pyrazole specifically inhibits liver ale, dehydrogenase and impairs the metabolism of EtOH. studies were undertaken in rats to evaluate the influence of inhibition of EtOH metabolism on the development ot an acute 23 EtOH-induced fatty liver. In agreement with previous observa tions, 20 hr after EtOH administration a 5-fold increase in hepatic triglyceride concn. occurred. In marked contrast, the pyrazole- and EtOH-treated group showed complete inhibition of EtOH- induced hepatic triglyceride accumulation. The prevention of the EtOH-induced hepatic triglyceride accumulation occurred ... -i.n . rf enhanced blood EtOH concns. in the ptrazole OLI 2567 Page 151 12--Mammalian Pathological Biochemistry Vol. 73, 1970 53940 163-89 (Japan). The cytotoxicities of histone fractions were investigated by using radiography and double staining method with neutral red and trypan blue. Histone fractions FI, F2B, F2A, and F3 extd. from the cancer cell (Ehriich ascites cell (EA)) and noncancer cell (calf thymus) showed similar activity on mouse L cells. However, early cultured LH cells (malignant transformed cells from L cells by EA histone K1) recultured from LH tumor were resistant to FI activity from EA. One more expt. was carried out by using another 3 human cells; PHEL (nononcofccnic), PPH (weakly oncogenic), and THEL (strongly oncogenic). Even in this expt. the activity was completely similar to those observed in L and LH and the cell response to both FI fractions was the highest in THEL. This gradual activity obtained in every cell was related to the arginine/lysine ratio of every frac tion with nearly the same amino acid compn. Possible cytotoxic abilities of amino acids and their polymers related to histone were also discussed. Hideo Kuroe 539281 Effects of post-treatment with caffeine on the sensi tivity to ultraviolet light irradiation of two lines of HeLa cells. Wilkinson, Ray; Kiefer, J.; Nias, A. H. W. (Paterson Lab., Christie Hosp., Manchester, Engl.). Mulct. Res. 1970, 10(1), 67-72 (Eng), The effect of UV irradn- was investigated on a std. line of HeLa cells and on a line sensitive to methyl methane- sulfonate (MMS). The MMS-sensitive line was found to be more sensitive to UV irradn. than the parent line. When the two cell lines were plated in caffeine-contg. medium immediately after UV irradn., there was no redn, in the surviving fraction of cells of either line, even when toxic conens. of caffeine were used. RCMR 53929y Synthesis of acid mucopolysaccharides by glial tumor cells in tissue culture. Dorfman, Albert; Ho, Pei-Lee (Dep. of Pediat., Joseph P. Kennedy, Jr. Mental Retardation Res. Cen ter, Chicago, 111.). Proc. Nat. Acad. Sci. US. 1970, 66(2), 495-9 (Eng). A clonal strain of rat glial tumor cells produced acid mucopolysaccharides, hyaluronic acid, chondroitin 4-sulfate, and heparin sulfate in tissue culture. The mucopolysaccharides were isolated both from the growth medium and the cells. RCYL 53930s Respiration and glycolysis of cells transformed with 4-nitroquinoline 1-oxide and its derivative. Sato, Kiyomi; Kuroki, Toshio; Sato, Haruo (Res. Inst. Tuberculosis, Leprosy, Cancer, Tohoku Univ., Sendai, Japan). Proc. Soc. Exp. Biol. Med. 1970, 134(1), 281-3 (Eng). Hamster embryonic cells transformed in vitro with 4-nitroquinoline 1-oxide and its deriv. exhibited an increased aerobic glycolysis and an inhibition of respiration by glucose addn. in the presence of pyruvate (the Crabtree effect). These changes, which are known to be charac teristic of many malignant cell strains, appear to be correlated with the grade of malignancy. RCTQ 5393It Mouse lysozyme production by a monocytoma: isola tion and comparison with other lysozymes. Riblet, Roy J.; Herzcnberg, Leonard A. (Med. Sch., Stanford Univ., Stanford, Calif.). Science 1970, 168(3939), 1595-7 (Eng). A transplant able mouse tumor, GPC-11, produces large amts, of lysozyme. The tumor is a reticulum cell sarcoma, type A, and is a neoplasm of monocytes. The lysozyme was purified from mouse urine in quantities sufficient for structural anal. Comparison of mouse lysozyme with lysozymes from chicken egg white and patients with monocytic leukemia reveals similarities in size and elec trophoretic mobility and, with human lysozyme, in functional properties. However, considerable differences are found in antigenic characteristics and amino acid compn. RCMH 53932U Plastic [-induced] carcihogenesis. Kogan, A. Kh. Mosk. Med. Inst. im. Sechenova, Moscow, USSR). Tr. 1 Pervogo} Mosk. Med. Inst. 1969, 66, 118-23 (Russ). Small capsules of nylon 6, polyethylene, Teflon, polystyrene, poly(Et terephthalate), poly(vinyl chloride), cellophane, rubber, colla gen, fibrin, or glass were implanted into 2100 rats s.c. The clin. observation of the implants after 12-27 months showed 34.6% incidence of blastomogenesis. The histol. examn. of the abnor mal tissues revealed a preponderance of sarcomas and fewer carcinomas and papillomas. The differences between blastomo- genetic activity of the tested materials are discussed. CPJR 53933V Transport into cytoplasm of nuclear DNA-like RNA in liver regeneration and chemical hepatocarcmogenesis. Plato nov, O. M.; Korotkoruchko, V, P.; Polishchuk, A. S.; Pinchuk, V. G. (Inst. Biochem., Kiev, USSR). Ukr. Biokhim. Zh. 1970, 42(1), 16-19 (Ukrain). Two fractions of "C-labeled DNA-like RNA (D-RNA-1 and D-RNA-2) were prepd. from isolated rat liver nuclei by thermal phenol fractionation (G. P. Georgiev and V. L. Mant'eva, 1962) at 55-63 and 63-85, rein Cyto plasmic RNA from normal liver competed wttn D-K.YA-1, but only slightly with D-RNA-2, in hybridization with DXA from liver nuclei, indicating that normal liver cytoplasm contains D-RNA-1 but only small amts, of D-RNA-2. In.regenerating liver (24 hr after partial hepatectoniy) and cancerous liver.(from rats administered dimethylaminoazobenzene for 2 faosithi), hybridization expts. showed the level of cytoplasmic D-RNA-2 to be greatly increased. I. Hajek 53934w Effect of a subfraction of carcinomatous rabbit serum 5-globulin on glycolysis and respiration. Galagan, N. P.; Stepanchenko, G. V.; Chernyavskii, E. I. (Inst. Biochem., Kiev, USSR). Ukr. Biokhim. Zh. 1970, 42(1), 70-80 (Ukrain). The effects of blood serum proteins of healthy rabbits and animals with the Brown-Pierce carcinoma, as well as of 3-globulin, on the processes of glycolysis and respiration were studied. Blood serum of carcinomatous rabbits, 3-globulin, and one of its sub fractions (protein positively reacting in the sedimentation test for carcinoma, PPR-STC) evoked a sharp activation of lactic acid formation in exts. of rabbit skeletal muscle. The addn. of healthy rabbit sera to such exts. decreased the intensity of lactate production considerably. When O absorption of myocardial mitochondria was studied, the addn. of healthy rabbit sera acti vated this process by 32% in comparison with the control and the cancer serum inhibited it almost to the same degree; 3-glohu- lin and PPR-STC inhibited by 59 and 75%, resp. I. Hajek 539351 Effect of isogenic lymphoid spleen cells on urethane carcinogenesis in the lungs of Af(B)-strain mice. Kraskovskii, G. V.; Gorelik, L. S. (Inst. Genet. Tsitol., Minsk, USSR). Vestsi Akad. Navuk Belarus. SSR, Ser. Biyal. Navuk 1970, (2), 109-11 (Russ), Carcinogenesis was produced in mouse lungs by urethane. Lymphoid (spleen) cells were obtained from normal isogenic mice and from those given the urethane. Injection of spleen cells from urethane-treated mice had no effect on the urethane carcinogenesis in the lungs. Spleen cells from isogenic normal mice suppressed inflammation in the lungs of treated females but stimulated adenoma formation in the males. L. Bakunowicz 53936y Excretion of unmetabolized 3,4-benzopyrene by rabbits, cows, and hens when it is present in food. Gorelova, X. D.; Cherepanova, A. I. (N. N. Petrov. Res. Inst. Oncol., Leningrad, USSR). Vop. Onkol. 1970, 16(4), 108-13 (Russ). Exptl. animals were given food supplements contg. 3,4-benzo- pyrene in daily doses of 86 y per rabbit for 5 months, 4.4^134 7 per hen for 4 months, 10 mg per cow for 80 days. Unmetabolized 3,4-benzopyrene was detd. in feces and urine once a month (in cows at the onset and end of expt.). The content in feces in creased in the rabbits from 0.34% of the daily dose (1st month) to 3.24% (5th month), in hens from 0.2 to 8% (lowest dose level) or from 0.06 to 0.46% (highest dose level). In 2 cows the excretion at the end of expt. was 24.0 and 1.7% of the daily dose. Only traces of the carcinogen were found in urine. Most of the compd. was metabolized prior to excretion. However, chronic intake of it altered the metabolic processes and enhanced the proportion of unmetabolized 3,4-benzopyrene in feces. I. Vavra 53937z Cytophotometric determination of DNA in plasmocytic nuclei of the spleen in rats with hormone-dependent tumors. Umanskii, Yu. A.; Antonyuk, R. D.; Gudim-Levkovich, K. A.; Lysyuk, L. P.; Ul'ysmova, t. X. (Res. Inst. Exptl. Clin. Oncol., Kiev, USSR). Vop. Onkol. 1970, 16(5), 61-5 (Russ). Female rats (strain Wistar) were castrated at age 2 months and a part of the ovary was implanted into the spleen. In 10 months after the implantation, tumors of various localization and size de veloped; the rats were then killed and the DNA content in the nuclei of plasmatic cells of the spleen was detd. cytospectrophotometrically. The DNA content depended on tumor localization with respect to the spleen. In the control animals, animals with tumors in the spleen, animals with tumors developed in other organs but not in the spleen, and animals in which tumors did not develop, the DNA content in each nucleus of spleen plasmatic cells was 2.84, 2.41, 5.09, and 5.72 arbitrary units, resp. V. Kleinwachter 53938a Water-salt metabolism in hypophyseal eosinophilic adenoma. Lebedev, A. A. (Ivanov. Med. Inst., Ivanovo, USSR). Zh. Nevropatol. Psikhiat. im. A. S. Korsakova 1970, 70(5), 689-93 (Russ). The antipyrine space (general content of water), the hyposulfite space (extracellular water), Na and K con tent in plasma, in erythrocytes, and in 24-hr urine was followed in 18 patients with hypophyseal eosinophilic adenoma and in 20 healthy subjects aged 35-410 years. A significantly bigger antipyrine and hyposulfite space was found in the patients in accord with the intracellular edema found in acromegalia. The changes occurred before the tumorous changes in hypothalamic area. The probability of hypersecretion of hypophysis anterior lobe hormones, resulting in disturbance of the water-salt metabolism, is supported by normalization after x-ray therapy. M. Hava 53939b Tumorigenicity of cyclic nitrosamines in Syrian golden hamsters. Lijinsky, William; Ferrero, A.; Montesano, R.; Wenyon, Charles E. M, (Med. Center, Univ. of Nebraska, Omaha, Nebr.). Z. Krebsforsch. 1970. 74(2), 1S5-9 (Eng), Ctai.y, mtosoazetidine was uoucareinogenic in hamsters, \\inle nitrosohcptamethyleneimine produced tumors in the esophagus, larnyx, pharynx, nasal cavity, forestomach, and trachea. Most of the tumors in the first 4 organs were malignant. Although this latter compd. produced bronchogenic carcinomas m the lungs of rats, this tumor was not induced in hamsters. DCJN 53940v Relevance of ehemicobiological interactions for the toxic and carcinogenic effects of aromatic amines. I. Carcino genic activity of some 4-aminostilbene and 4-aminobibenzyl deriv es ? --1 y * r> ~ O LI 2568 4*11, 'mML. 41109 *. 11 nhufri itr ~ i Chemical Abstracts Vol. 72, 1970 tsJ, u, Pe 216 14--TOXICOLOGY T. R. T0RJKEL50N 41109i Toxicology of vinyl chloride. Schottek, Wolfgang James A.; Seibold, H. R. (Tulane Univ., Covington, La.). . (Abt. Arbeitstoxikol., Holzweissig, Ger.). Chem. Tech, (Leip Toxicol. Appl. Pharmacol. 1969, 15(3), 024-31 (Eng). The zig) 1969, 21(11), 708-11 (Ger). A review with 24 refs. The toxic effects of ethylene glycol in several macaque species are re toxicity of vinyl chloride in animals and humans, and the relation ported. The compd. was administered in the drinking water at of the chem, structure of the compd. to its toxicity were dis conens. of 0.25-10%, and histol. studies were made after acute .'! cussed. CCJG and chronic administration. With the exception of a few animals s 4U10r Microscopically contrasted heavy metal intoxication. (which had Ca oxalate crystals in the brain), significant pathol. i i Silver sulfide process, a method for localized histochemical de alterations were limited to the kidneys. Animals receiving 15 tection of heavy metals in tissues. Haider, Gerhard (Ger.). ml/kg or more of ethylene glycol had Ca oxalate crystals within Mikrokosmos 1969, 58(9), 272-5 (Ger). A review of work is pre proximal renal tubules and assoed. tubular degeneration. De sented which illustrates the value of the combination of light mi spite the absence of crystals in animals receiving <15 ml/kg, mild croscopy with histochem. techniques for the detection, localiza glomerular damage was found, and azotemia occurred in some tion, and identification of Hg, Pb, Bi, Fe, Zn, and Cu in cells and animals, suggesting a toxic effect of ethylene glycol apart from its tissues. Highlights of the silver sulfide histochem. procedure are conversion to oxalic acid. RCZB presented along with representative photomicrographs. 6 refs. 41120U A clinicopathologic study of the effects of riot control Nellie G. Dehnbostel agents on monkeys. IV. o-Chlorobenzylidene malononitrile 'j 41111s Development of the hemodynamic, biochemical, and (CS) grenade. Striker, G, E.; Streett, C. S.; Ford, D. F.; morphologic changes in experimental endotoxin shock. Sten- Herman, L. H.; Helland, D. R. (Edgewood Arsenal, Md.). gert, Krzysztof (Z Zakl. Anestezjologii, AM, Lodz, Poland). U.S. Clearinghouse Fed. Sci. Tech. Inform., AD 1967, AD-808- -ff Postepy Hig. Med. Dosw. 1969, 23(5), 601-59 (Pol). A review 732, 39 pp. (Eng). Avail. CFSTI. From U.S. Gout. Res. De is given of methods for detg. hemodynamic, biochem., and mor- velop. Rep. 1969, 69(19), 123. A study was made of the order, phol. changes, the course of changes in dogs, clin. evaluation and severity, and resolution of pathol. changes in monkeys exposed to patterns, and damage to tissues and organisms during exptl. endo CS. Monkeys were exposed to CS (2700, 8500, 28,500, or toxin shock. 146 refs. Y. Pomeranz 80,000 mg min/m')- The most prominent lesions seen after the 41112t Saponins. Birk, Yehudith (Hebrew Univ., Re- 2 lower doses were mild pulmonary congestion, bronchorrhea, hovoth, Israel). Toxic Const. Plant Foodst. 1969, 169-210 emphysema, and atelectasis. These lesions cleared by 72 hr but (Eng). Edited by Liener, Irvin E. Acad. Press: New York, recurred at 1 week and 30 days. Oral and nasal discharges and N.Y. Dietary source, metabolism, and effects of various sapo dyspnea appeared early after a level of 28,500. They were most nins are given with methods for qua), and quant, analyses. 167 severe between 12 and 24 hr and were resolved by 72 hr. Pneu - refs. E. A. Hodgdon monia, emphysema, and atelectasis were present 1 week and 30 41113U Chromatographic identification of psychotropic drugs. days after exposure. Significant lesions were seen radiographi Phillips, Geoffrey F.; Gardiner, Jane (Lab. Govt. Chem., Lon cally only in those monkeys exposed to a level of 80,000. These don, Engl.). J. Pharnt. Pharmacol. 1969, 21(12), 793-807 lesions paralleled those seen on necropsy. At this level edema (Eng). The thin-layer chromatog. of 3 classes of psychotropic appeared by 12 hr, peaked between 24 and 48 hr, and cleared by drugs, phcnethylamines, tryptamines, and erganes, has been in 1 week. .Emphysema and bronchiolitis were present 1 week and vestigated. Published methods are reviewed and R/ data, nor 30 days after exposure. TCVL malized by a graphical technique, are reported for extensions and 41121v Experimental study on gas embolism with particular modifications of some of these systems. Optimum forensic sort reference to the differentiation between embolic gas and gas ing procedures are recommended. RCHQ from putrefaction. Pierucci, Giovanni; Gherson, Gemma i Inst. 41114v Estimation of lead in urine by atomic absorption Med. Legale, Univ. Pavia, Pavia, Italy). Zacchia 1968, [31 4(3), analysis. Taira, Yoshiko. Nippon Eiseikensa Giskikai Zasshi 347-73 (Ital). Embolism was induced by injecting air or He 1969, 18(5), 389-91 (Japan). The PbI+ was extd. into iso-Bu- i.v. into living (followed by instant death), and i.v. or intracardi- COMe soln. from 30% NH,OH. The recovery rate was 99.9%. ally into sacrificed, rabbits, and gas was aspirated from the heart The reproducibility of at. absorption measurement was 1.4%. at intervals. Putrefaction gas was aspirated from the heart and No interference from other ions was noticed. T. L. Chang abdominal cavity of rabbits and human cadavers 1-13 days, and 41115w Determination of toxic substances and their me 15-236 days, after death, resp. In samples of air embolic gas, tabolites in biological fluids by gas chromatography. I. Tri- Oj decreased and 1 hr after death was insignificant; CO; was chloroethanol in urine. Sedivec, Vaclav; Flek, Jan (Ustav Hyg. present immediately; N* levels were relatively staBle, similar to Prace, Prague, Czech.). Prac. Lek. 1969, 21(7), 301-5 (Czech). air, for 2 days, then decreased sharply. In He embolic gas, See C.4 70: 113446p. VNJZ Oj, Nj, and COj were present immediately. Results were essen 41116x Aflatoxin Bi in the excretion of aflatoxin-poisoned rats. Chou, Ming-Wu; Tung, Ta-Cheng (Coll. Med., Nat. Taiwan Univ., Taipei, Taiwan). 7"ai-Wan J Hsueh Hui Tsa Chth 1969, 68(8), 389-91 (Eng). Aflatoxin Bi was detected in the rat urine and feces after i.p. injection of the toxin. Most of the aflatoxin Bi was excreted in the first 24 hr. The percentage re covery was about 1.5%. A thin-layer chromatographic method tially the same in rabbits injected before and after death. Av. values for putrefaction gas contents in rabbit and cadaver heart were, resp,: Ot 1.32 and 2.05%, Xj (usually <50%) 12.13 and 22.06%, COi 31.08 and 50.62%; CHt appeared early and almost ' constantly in the rabbit. F- Earnara 41122w Early effects of carbon tetrachloride on the synthesis of phospholipids in the rat liver and their possible pathogenetic was a simple way for detg. the aflatoxin conen. of the excretions, role in fatty liver induction. Halbreich, A.; Mager. J. iHa- and could provide useful information for detecting it in humans. dassah Med. Sch., Hebrew Univ., Jerusalem, Israel). Biochim. N. M. Wright Biophys. Acta 1969, 187(4), 584-7 (Eng). In rats, i.p. injections 41117y Paper chromatography of Taxus baccata toxin. Bu- of CCI4 in doses as low as 0.5 ;il/100 g reduced the ability of liver i bien, Zenon (Wyzsza Szk. Roln., Wroclaw, Poland). Zesz. microsomes to incorporate choline-1*C into total phospholipids Nauk. Wyzsz. Szk. Roln. Wroclawiu, Wet. 1968, No. 23, 215-21 and labeled L-leucine-I-'*C into protein, discernible as early as 1 (Pol). The presence of toxin in T. baccata (English yew) needles, 10-15 rain postinjection and lasting for 20 hr. Incorporation in fodder, and in the alimentary tract content was detected by patterns of choline were identical whether the radioactive choline i paper chromatog. The alkaloid was extd. from the biol. ma was labeled in the Me groups or in the 1,2-carbou atoms. The i terial by EtjO, purified with active C, and chromatographed in magnitude of choline inhibition was not altered by varying the the form of aq. HC1 soln. The chromatograms were developed dose of labeled choline over a 1000-fold range, attesting to the i at 18 by the ascending technique, using as solvent either BuOH- independence of this phenomenon of the attendant variations in .J 80% AcOH-anhyd. EtOH-HiO (50:7:2:15), or 75% aq. (NH.)j- the internal pool size of free choline. Ethionine (1 mg g) and J SOi. The R/ values were 0.95 and 0.75, resp. The toxin spots dimethylnitrosamine (10 mg/100 g) did not affect the incorpora were stained by the Draggendorf reagent. Irena Kloczko 41118Z Errors of converting a urine alcohol value into a blood alcohol level. Kave, Sidney; Cardona, Eduardo (Sell. Med., Univ. Puerto Rico, Rio Picaras, P.R.). Amer, J. Clin. Pathol. tion of choline into liver phospholipids, although they inhibited protein synthesis. CCI4 enhanced the incorporation of ethanolamine-2-'1 C into liver microsomal phospholipids. The early on set and the long persistence, as well as the specinc nature, of the de CTi CD in CN 1969, 52(5), 577-S4 (Eng). Evidence is presented for the in advisability of ealeg. blood EtOH levels on the basis of urine EtOH content. EtOH content was detd. in the blood and urine r of -MS patients and the ratio of urine/blood was caled. The rangement of phospholipid synthesis by CCI4 suggest a possible role of this phenomenon in the pathogenesis in fatty liver. BKT.V 41123x In vitro inhibition of succinate and pyruvate oxidation H a o s rapge.of ratios was 0.21-2.66 with a mean ratio of 1.28. Blood by ethanolic extracts of grasses, legumes, and dystrophogenic 'levels were ealed. from urine levels using a conversion factor of forages. Cheeke, Peter R.; Oldfield, James E. (Oregon state 1.28 and compared with measured values. Caled. values ex Univ., Corvallis, Oreg.). Can. J. Anim. Sci. 1969, 49% '. 402-4 ceeded actual values by at least 0.02 g/ml in 21.5% of the cases (Eng). EtOH exts. of title plants inhibited in vitro oxidn. of and were lower by the same amt. in 34.5% of the cases. both succinate and pyruvate by rat liver homogenates, fixes, of J. R. Macnab 2 dystrnnhoeenic forages did not inti-hit tigri-vp ' r'' M* 51 11--Mammalian Biochemistry Vol. 71, 1969 110573 61. ,,,mals. The major difference lies in the larger maintenance ^uirements of the mouse due to its higher metabolic rate. 'T<* Philip Jacobson 110563) Levels of immunoglobulins (vG.vM.vA) in normal .k.Mren. Tabata, Kihachiro (Kyoto Univ., Kyoto, Japan). Wrniha Kiyo 1968, 14(6), 379-86 (Eng). Levels of serum L. munoglobulins were detd. by the antibody agar plate method in -jtcrnal and cord blood at the time of delivery and in groups of j.mial infants and children up to age 15. yA was absent from \,r(f blood, yM present only in traces, whereas the levels of yO c0rd blood were equal to or above those in maternal blood. M. nimum levels of yO were found at 3 and 6 months, then rose | ly, not attaining the adult range until age 11. Levels of yM rtjrhed half the range found in adults by 3 months, but did not nidi adult levels until 3 yrs. Levels of yA were less than half U adult range up to age 5, then rose rapidly. Jacob Sacks 110564k Polymorphism of transferrins of bovine, porcine, and (inine sera, as determined by means of acrylamide-gel disc ilectrophoresis. Dorner, Joseph L. (Univ. of Illinois, Urbana, I".!.). 1968, 66 pp. (Eng). Avail. Univ. Microfilms, Ann Arbor, Mich., Order No. 69-10,687. From Din. Abstr. B 1969, 29(12), *727. SNDC 110565m Hemoglobin-Lepore Baltimore, a third type of a iff nassover (tu, ff**). Ostertag, Wolfram; Smith, Ernest Wendell S:h, of Med., Johns Hopkins Univ., Baltimore, Md.). Eur. J. Fbichem. 1969, 10(2), 371-6 (Eng). A new Lepore-type Hb in a person of Negro descent has been identified. In this- person a minor Hb (Hb-LeporeB*nio,o,) was detected. An abnormal (j-chain was isolated and fingerprinted. This hybrid-type pro- urn presumably arose as a consequence of unequal crossing over between the i and ff genes, as was concluded for Hb-LeporeBWB sad Hb-LeporeHotUndu- In the new Lepore-type Hb described here the crossover could be placed between residues iw and ff". This type of crossover should occur with the highest frequency if ctossing over is equally frequent between any nucleotides and if Klection favors none of the crossover types. RCBY 110566n Genetic and developmental regulation of hepatic Uminolevulinate dehydratase in mice. Doyle, Darrell J.; Schimke, Robert T. (Sch. of Med., Stanford Univ., Stanford, Calif.). J. Biol. Chem. 1969, 244(20), 5449-59 (Eng). The mechanism by which the levulinate locus (Lv) regulates the tissue setivity of 4-aminolevulinate dehydratase in mice has been exarod. The assayable hepatic enzyme activity in homozygous Lt,b mouse mains, represented by C57B1/6, is between one-third and one- half that of homozygous Li* strains. This difference in enzyme activity is due to a difference in amt. of enzyme protein as demon- mated by immunochem. techniques with an antibody specific for i-aminolevulinate dehydratase. Combined immunochem. and notopic techniques show that the levulinate locus regulates the ronen. of hepatic J-aminolevulinate dehydratase by acting at the level of enzyme synthesis. The rate of degradation of hepatic enzyme is the same in both low and high activity strains; when repressed as a half-life, this is equal to 5-6 days. The pattern of I-aminolevulinate dehydratase development with age is similar m livers of both low and high activity strains. The specific activity of the enzyme is high in fetal liver, decreases during the teveral days prior to birth, and increases to the adult level during the first 3 weeks of postnatal life. The activity of 3-amino- evulinate dehydratase in fetal liver is also regulated by the evulinate locus. The enzyme in fetal liver is approx, twice as s-hvc catalytically as the enzyme in adult liver relative to its faction as an antigen. The fetal enzyme also appears to be -:Strent in stability to heat and proteolytic inactivation. How e'er, fetal and adult enzymes are similar by other physiochem. criteria, including electrophoretic mobility, sedimentation coeff., t-d A, for the substrate. RCJN 110567p Identification and genetic control of two new low* "?"*y lipoprotein allotypes: phenogroups at the Lpq locus- J oers, John J.; Dray, Sheldon (Med. Center, Univ. of Illinois, Lvicago, 111.). J. Immunol. 1969, 103(2), 155-62 (Eng). See Cl 69:104403z. VNJZ 110568q Modification by crude histones of gene activity for "V** dehydrogenase. Latner, A. L.; Longstaff, E. (Roy. 'etoria Infirmary, Newcastle upon Tyne, Engl.). Nature 1969, 224(5214), 71-3 (Eng). Addn. of crude calf ymus histone to the mouse kidney organ culture increased the 0portion of the lactate dehydrogenase (LDH) isozymes which o'ed more rapidly toward the anode during electrophoresis. crude rat liver histone fraction was added to the culture, the ,rase was in the direction of the slower moving LDH isozymes. 1 >- cultures exposed to the crude caif thvmu? histone, the , ,yit of LDH-1 and the H subunit contribution to the total activity significantly increased, whereas the opposite was -I with the rat liver histone prepn.; LDH-5 and the M sub- Slriiificantly increased. Enrichment of the medium with , ac,ds present in the calf thymus histone prepn. did not ,, the isozyme pattern, indicating that the changes in LDH 'em were not caused by hydrolysis of the histone. Gene *'hg by histones apparently is nonspecific, and the crude ext. may contain factors, not necessarily histones, which affect gene activity in a manner that is not species specific. BSJN 110569r Changes in the activity of isolated vascular smooth muscle in response to reduced osmolarity. Jonsson, Olof (Univ. Goteborg, Goteborg, Swed.). Acta Physiol. Scand. 1969, 77(1), 191-200 (Eng). The effects of hypoosmolarity on the spon taneous activity of the smooth muscle in the isolated portal vein of the rat have been studied in solus, with varied ionic compn. A comparison between the stimulatory effects of lowered osmolarity and increased [K+]0 (external K+ concu.) indicated that at normal [K+jt in the control state the excitation caused by hypo- tonicity is not mediated only via changes in the [K^],/[K+]o ratio. The response to hypoosmolarity at a higher [K*]t is, however, more readily explained by the change in lK+),/[K+]o which occurs in assocn. with the swelling of the cells. This might be attributed to the fact that the membrane potential of smooth muscle is more dependent on the transmembrane concn. gradient for K-1 at higher levels of iK+Jo. The stimulatory effects of hypo osmolarity are markedly reduced at a low [Xa+]t but are not considerably affected by comparable redns. in [K+]o or [Cl']0. This indicates that the transmembrane Xa+ gradient is involved in the mechanisms by which hypoosmolarity excites the spon taneous activity of vascular smooth muscle. One possible interpretation is that the swelling of the muscle cells in hypotonic solns. causes an increase in the permeability of the cell membrane to the relatively larger Na+. RCVV 110570j Secretion of rat pancreas perfused with plasma from rats fed soybean trypsin inhibitor. Khayambashi, H.; Lyman, R. L. (Univ. of California, Berkeley, Calif.). Amer. J. Physiol. 1969,217(3), 646-51 (Eng), When plasma from rats fed soybean trypsin inhibitor was perfused through an isolated, fasted rat pancreas, amylase secretion was 2-3-fold greater than that of a pancreas perfused with plasma from rats fed the same diet without trypsin inhibitor. Addn, of atropine to the perfusate did not inhibit the secretory response. The plasma factor was relatively unstable upon storage at 4 (50% loss of activity in 4 days) and appeared to be assoed. mainly with those plasma proteins of 10,000 mol. wt. or less. Thus, active soybean trypsin inhibitor enhanced the formation and (or) release of a humoral pancreozy minlike substance that markedly stimulated external enzyme secretion of the rat pancreas. RCDH 110571k Effects of diet and catechol amines on bile acid metabolism in dogs. Gans, Joseph H.; Cater, Marilyn R. (Coll, of Med., Univ. of Vermont, Burlington, Vt.). Amer. J. Physiol. 1969, 217(4), 1018-24 (Eng). Five adult male dogs were surgically prepd. with polyvinyl tubing placed in the upper duodenum. Each dog was given cholic-carboxyl~uC acid and samptes of gallbladder bile were withdrawn over a 10-day period. The taurocholic acid pool was 1.09 g./lO kg. body wt. and half- life was 3.2 days when dogs were given a dry dog food diet. Epinephrine in oil, 0.8-1 rog./kg./day, increased plasma cho lesterol concns., produced a 23.9% redn. in the taurocholic acid pool size, and increased the rate of decline of specific radioactivity of both taurocholic and taurodeoxycholic acids. The halt-life of taurocholic-1* C acid during epinephrine administration was 1.6 days. Norepinephrine in oil, 0.8-1.0 mg, free base/kg./day, produced a modest decrease in the half-life of taurocholic-1*C acid without significant elevations in plasma cholesterol concns. A dietary supplement of l/i lb. beef plus 2-3 g. of cholesterol per day resulted in increased plasma cholesterol concns., increases in the taurocholic acid pool size, and a decrease in the half-life of taurocholic-1*C acid. Epinephrine administration further in creased plasma cholesterol concns. in cholesterol-fed dogs, but did not significantly alter bile acid metabolism. RCDH 110572m Effect of osmolarity on canine renal vascular resistance. Gazitua, Sergio; Scott, Jerry Benjamin; Chou, Ching-Chung; Haddy, Francis J. (Michigan State Univ., East Lansing, Mich.). Amer. J. Physiol. 1969, 217(4), 1216-23 (Eng). The effects of changes in renal blood osmolarity, pro duced by close intraarterial infusion of solns. of dextrose, NaCl, and urea, on renal resistance were systematically examd. in the dog. Infusion of a hyperosmotic soln. of dextrose for 3 min. produced a fall in renal vascular resistance which was sustained for the entire infusion period. On termination of the infusion, resistance returned to the control level. Infusion of a soln. of hyperosmotic NaCl or urea, on the other hand, produced a fall in resistance which waned with time. Furthermore, on stopping the infusion, resistance transiently rose well above the control level, particularly in the case of urea. Intraarterial infusion of an isosraotic soln. of urea and of hyposmotic solns. of all three substances produced large increases in resistance. Studies con cerning lymphatic vessel pressure and cell-free perfusion, as well as the findings of others, are consistent with the.hypothesis that the changes in resistance result, to a large extent, from active vasomotiOn, possibly due to osmotic changes in the water content of the smooth muscle cells. RCDH 110573n Metabolism of allyl compounds in the rat. Clapp, J. J.; Kaye, C. M.; Young, Leslie (St. Thomas's Hosf. Med. Sch., London, Engl.). Biochem. J. 1969, 114(1), 6P-YP-_(Eng). A mercapturic acid was isolated from the urine of rats treated s.c. OLI 2570 7/ //<rSr 73-*./ 110574 Chemical Abstracts Vol. 71, 1969 with CH*:CHOAc or Cl-Ij:CHOH and identified as 3-hydroxy- propylinc-rcapluric acid (,V-acctyl-5-(3-hydroxypropyI)-L-cys- tcine, I). There was no evidence for the presence of allylmcr- capturic acid (jY-acctyl-5-allyl-L-cystcine, II) in the urine of these animals. II, however, was detected in the urine of rats injected s.c. with CHjiCHCl, 5-ally]glutatl:ione, and 5-allyl-L- cysteine. Rats treated with CHjiCKCI also excreted I. Mer- capturie acids apparently arise by the reaction of aUyl compds. or their active derivs. with glutathione. BQJN 110574p Metabolites of octoclothepine eliminated in human and rat urine. Queisnerova, Milena; Svatek, E.; Metysova, Jirina (Res. Inst. Pharm, Biochem., Prague, Czech.). Biochem. J. 1969, 114(2), 339-42 (Eng). Pour metabolites and Unchanged octoclothepine were extd. with dichloroethane from the urine of humans given octoclothepine. These substances were isolated and purified by column and thin-layer chromatog. By chro matographic, spectrophotometric, and polarographic anal., unchanged octoclothepine and 3 of the metabolites were identified (noroctoclothepine, noroctoclothepine 5-oxide, and octoclothe pine 5-oxide). The presence of glucuronidcs in human urine was shown. The same metabolites and unchanged octoclothepine were also found in rat urine by chromatog. RCFG 110575q Mechanism by which leucine and arginine stimulate insulin release in vitro. Milner, R. D. G. (Univ. West Indies, Kingston, Jamaica). Biochim. Biophys. Acta 1969, 192(1), 154-30 (Eng). Basal insulin release in young rabbit pancreas slices in vitro was higher in the presence of leucine (5m#) than of arginine (5m#) (in the absence of glucose). Glucagon (5 jig./ml.), theophylline (ImM), dibutyryl cyclic AMP (lm#), or L-arginine (5m#) stimulated insulin release in the presence of leucine but not in the presence of arginine. Arginine-stimulated basal insulin release perhaps works by releasing glucagon from the a-cells. The mechanism of the leucine-induced stimulation is different, probably via the adenyl cyclase system. BSJN 110576r Cytochemical study of the distribution and content of nucleoproteins and of some functional groups of proteins in iso lated formations of the central nervous system following foreign protein injection. Tumanyan, E. L. (Erevan. Med. Inst., Erevan, USSR). Biol. Zh, Arm. 1969, 22(5), 97-8 (Russ). Cytoplasm of various parts of rabbit central nervous system (including intervertebral ganglia, nuclei of the XII cranial nerve," and skin motor area of brain cortex) displayed higher ribonucleo- protcin content in animals treated with repeated i.v. injection of normal horse serum. The peak effect was observed on the 4th day after the last injection. N > changes were seen in content and distribution of protein SH groups. N. Jasinczuk 110577s DNA synthesis in mouse embryonic fibroblast-like cells in vitro, stimulated by various factors. Vasil'ev, Yu. M.; Gel'fand, I. M.; Gel'shtein, V. I.; Fetisova, E. K. (Mosk. Gos. Univ., Moscow, USSR). Dokl.Akad. Nauk SSSR 1969, 187(4), 913-15[Cytol] (Russ). Autoradiography was used to follow the DNA synthesis in single-layer cultures of mouse embryo fibro blast-like cells in lactalbumin hydrolyzate and ox serum media in the presence of thymidine-1# added at various periods of culture age. The index of 'H inclusion was increased by addn. of tes- tjcular or bacterial hyaluronidases, RNase, and digitonin. The rise of "H intake was the result of stimulation of the entry of the cells into the S-phase of development. G. M. Kosolapoff 110578t Effect of pregnancy and oral contraceptives on glu cose and insulin metabolism. Taskinen, Marja R. Duodccim 1969, 85(11), 676-83 (Finnish). A review. The effect of both pregnancy and oral contraceptives is diabetogenous, and they may cause deterioration of glucose tolerance in healthy women. The organism tends to compensate this by enhanced insulin secretion, which leads to hyperinsulinism. 43 references. I, G. Zewi 110579u Effect of pyridoxal 5'-phosphate on the strength of skin in vitro. Harkness, Robert D. (Univ. Coll. London, Lon don, Engl.). Experientia 1969, 25(10), 1048-9 (Eng). Treat ment with 10m# pyridoxal 5'-phosphate (I) in vitro reduced the strength of rat tail skin progressively with time of incubation. The redn. was reversible, with strength returning when the skin rings were placed in buffered saline. Pyridoxamine or pyri- doxine at 10m# had no comparable effect. The effect of I was reduced in the presence of lysine. Pretreatment of the skin with NaBHj, followed by washing in saline buffer, largely inhibited the effect of I. Pretreatment with NHtOH also inhibited the effect of I. Treatment with NHiOH after I prevented the re covery of strength on subsequent transfer to the saline buffer; H-NNH. had a similar effect. The effect of I on skin strength is apparently brought about by rupture of azomethine linkages formed between an aldehyde and an ammo group. BSJN 110580n Diabetogenic effect of L-asparaginase. Khan, Amanullah; Adachi, Mitsuo; Hill, Joseph MacGlashan (Wad- ley Inst, of Mol. Med., Dallas, Tex.). J. Clint Endocrinol. Metab. 1969, 29(10), 1373-6 (Eng). The effects-of Escherichia eoli L-asparaginase (500-50,000 I.U./kg., i.v.), which has been used to induce remission of human acute lymphatic and myelog enous leukemias via depletion of an amino acid essential for some neoplastic cells, on rabbit blood and urinary glucose levels were studied. A dose of 2000 I.U. L-asparaginase/kg. rw,' glycemia and glycosuria in most of the animals; tin dose which induced hyperglycemia when given to : , rabbits receiving 10,000 I.U. L-asparaginase/kg, or diabetogenic responses, but these effects were tern-; days) and were not assoed. with any histological T: i pancreatic islets, except in 1 rabbit which showed i I. tion. 110581 p Effect of Bidrin on the metabolism of <1 ponents by the bovine. Lowrey, R. S.; Bowman..'.. Knox, F. E. (Coastal Plain Exp. Sta., Agr. Res. Sci . Ga.). J. Dairy Sci. 1969, 52(9), 1460-3 (Eng), averaging 400 kg. in wt. were used in a switchback tr: the effect of spiking corn silage with 15.7 ppm. in.. body wt.) of the pesticide Bidrin [3-(dimethoxyph..... fV.iV-dimethyl-w-crotonamide] on blood cholinestcr. ibility of dietary components, utilization of N, and run., tation. Bidrin residues were not found either in the : the feces of animals ingesting Bidrin. Azodrin, a uu . Bidrin, was not present in the feces of treated anim,i. aged 0.430 ppm. in the urine. Based on urine vol. > sented 1.5% of the ingested Bidrin. Blood choline depressed to 30% of pretreatment values by the end of , exptl. period, whereas activity of steers fed untreated . unaffected. In the metabolism trial conducted dure 14 days of the 42-day period Bidrin had no effect on ; ibility of dietary components (dry matter, crude pm. ext., crude fiber, N-free ext., and gross energy), the t of N, or rumen fermentation. i 110382q Effect of a second dose of cadmium salts on permeability in the rat testis. Clegg, E. J.; Carr, Ian, M. (Univ. Sheffield, Sheffield, Engl.). J. Endocrine! (2), 265-8 (Eng). Two doses of CdClj were given > intervals varying from 76 to 194 days. After the secou i blood vessels in the testis and Initial segment of the <.;> showed increased permeability, as demonstrated by i.v. In the testis, leaking vessels were usually found in at,. interstitial cells were abundant. 1. 110583r Acid-base and electrolyte changes induced 1 isotonic saline infusion in the nephrectomized dog. Re. . Barrjr J.; Makoff, Dwight L.; Maxwell, Morton R., oughi, Michael (Cedars-Sinai Med. Res. Inst., Los . Calif.). J. Lab. Clin. Med. 1969, 74(3), 427-35 (Ho rnechanism and extent of "dilution acidosis" by acute of isotonic saline was studied in nephrectomized dogs, of 50, 75, and 100 ml./kg. of body wt. (BW) (Groups 1. over a 30-min. period resulted in extracellular fluid expo- 24.4 1.7%, 28.8 2.2%, and 33.9 5.5%, resp. . kept const. Body spaces were measured isotopicallv, a: cellular H+ activity by 5,5-dimethyl-2,4-oxazolidincd The extracellular bicarbonate concn. decreased only --3 meq./l. and --2.5 0.4 meq./l. in Groups J and 2 am; 1.0 in Group 3. The total amt. of extracellular bicarb creased +0.6 =fc 0.2 meq./kg. of BW, +0.8 0.2 im BW, and +1.5 0.4 meq./kg. of BW in each group, rev constantly, the total amt. of extracellular fluid K incrcz. 0.0 meq./kg. of BW, +0.5 0.1 meq./kg. of BW, .. 0.1 meq./kg. of BW, resp., while there was no dc, extracellular K concn. It was suggested that the extras, carbonate and K concns. were defended by shifts of H* (or bicarbonate out of cells), in conjunction with a si:: out of cells. Despite the presumed H+ (or bicarbon;, there were no net changes of H+ activity. The ci theory of extracellular "dilution acidosis" is valid but <. magnitude and little clin. significance when expansion is r- slow. Cellular buffering minimizes the extracellular . and the shift of K out of cells prevents hypokalemia, k 110584s Effect of erythropoietin on bone marrow . levulinfc add synthetase and heme synthetase. Be Sylvia S.; Smithee, G. Ann (Veterans Admin. Hosp., u City, Okla.). /. Lab. Clin. Med. 1969, 74(3), 445-5. An in vitro culture method has been adapted for rab marrow and has permitted measurement of the effect of poietin on A-aminolevulinic acid synthetase and heme activities in marrow cells. In this system, erythrop; hanced A-aminolevulinic acid synthetase activity. I- was detectable as early as 6 hrs. after contact with erytlir : The max. enzyme activity observed was 200% greater ulated than in control cultures. Studies with inhibit*' tein synthesis suggested that erythropoie'm men thesis of the enzyme. No stimulatory effect uy cr.. on heme synthetase activity was observed. 1105851 Action of adenosine triphosphate on the spontaneous electrical activity of the dog cerebral cor:. Gian; Arrigoni, Elena; Ferrara, A.; Maschcipa. : Pharmacol., Univ. Pavia, Pavia, Italy). J- J'hatni. ' 58(9), 1161-3 (Eng). The repeated suppression of tn. tion and the circulation of the brain in the dog induce' pression or a silence of elec, activity of the cortical cortical centers. The recovery of respiratory and ns OLI 2571 14--Toxicology Vol. 70, l,c fatty acid compn. of the brain between HCN- '] untreated rats. N. Constantsas. Curative antagonization of liver damage caused by "With silymarin as a model of antihepatotoxin therapy. ' nilicr; Tcmme, Inge (Biol. Inst. Madaus, Cologne, i`.:uciin.-Forsch. 1969, 19(4), 013-15 (Oer). Silymarin, -p.itotoxic agent in the seeds of SHyhum mannnum, [lie toxic effects of phalloidin in mice, Silymarin was .jic in reversing the toxic effects of phalloidin in mice j fjrst with this compd. and then treated with siiy- 'i,c antiphalloidin effect, of silymarin depended on the -v.il between intoxication and treatment, and on the iiv or damage. BQJG Evidence for the bioactivation of slaframine. Aust, 1 ' (Michigan State Univ., East I-ansiiig, Mich.). Bio- ,:rmncol. 1969, 18(4), 929-32 (Eng). Max. salivary iii pentobarbital-anesthetized cats occurred ~1 hr. .ulininistration of slaframine (0.3 mg./kg.); the dura- Jiration was extremely long, usually lasting for 0 hrs. ,dc dose. In addn. to salivation, most of the exocrine ..rc specifically stimulated by slaframine. Upon ad- . poo of slaframine to cows, sheep, and goats with pan- ,nnulas there was also a substantial delay before an inpincreatic flow was observed. In mice, a longer delay 1 jlter i.v. injection of 2 mg./kg. than with i.p. adminis- the same dose; this delay was decreased by injection *..,to the portal vein. Delay of the effect of the drug at ,,, was siguificantly extended by briefly isolating (with the liver of rats; the effect was completely eliminated xrmanent isolation of the liver. Common inducers of v.-.mctabolizing enzymes consistently reduced the delay ejection of salivation in mice, while inhibitors of the en- .. [.insistently lengthened the delay. Thus, slaframine ., require activation by the liver before stimulating exo- ;ands. The enzymes involved in this activation are ... iv those responsible for the metabolism of most xeno- / BYJN vxq Metabolism of phospholipids in the brain and liver ,3 during intoxication with organophosphorus compounds. . V. Ya.; Tofilo, A. P. (Pavlov Inst. Physiol., Lenin. . nSR). Byull. Eksp. Biol. Mid. 1969, 67(3), 50-2 (Russ). hosphonts compds. LG-63 (5 mg./kg.) and GA-81 (0.4 n i administered i.m. to rats did not affect the level of -.. lipids in the brain and liver or the rate of restoration of hpids in the brain. The metabolism of phospholipids iwcr was increased 24.8% by organophosphorus compd. r=d 32.4% by GA-81, The increased intensity of phos- -! metabolism may be connected in some way to increased > of the hepatic cells during detoxication of the cholin- - inhibitors. BJJR -i!5r Toxicity studies in mice treated with 1-0-D-arabino'*>(cytosine (ara-C). Leach, William B,; Laster, W. Jr.; Mayo, Joseph G.; Griswold, Daniel P., Jr.; Prank M., Jr. (Med. Center, Univ. of Alabama, mam, Ala.). Cancer Res. 1969, 29(3), 529-35 (Eng), -m therapeutic dosage schedules of 1-d-p-arabinofurano- *me (ara-C) administered i.p. in mice (15 mg./kg., every ' ;'r 24 hrs.) result in karyorrhectic damage to the crypt -*1 cells of the intestinal mucosa. This damage is most ` *' 4 hrs. (earliest observations made) after the end of the '-arse, after which there is a rapid recovery to completion 'l- The damage is thus transitory and resembles that of /uirea. This cycle of transitory intestinal damage fol- V recovery occurs after each therapeutic dosage schedule '* e as long as the schedule is not repeated more often than hh day. Progressive damage to the intestinal mucosa -anied by changes in the hematopoietic tissues occurs 'ms optimum therapeutic dose (15 mg./kg., every 3 hrs.) "*ucd uninterrupted to the LDu dose (360 mg./kg. in and beyond. Irreversible changes are seen in the in- . *' niucosa, and a progressive depopulation of the bone . ultimate aplasia ensues as the LDwo dose is reached 'hissed. RCTT Effect of butylated hydroxytoluene (BHT) on rat '0);"rome oxidase activity. Pascal, Gerard; Terroine, .. ' ,'-cntre Rech. Nutr., C.N.R.S., Bellevue, Fr.). C. R. Paris, Sir. D 1969, 268(11), 1529-31 (Fr). The oral . .. of BHT (0.05% in the food, a concn. 50-fold 1 in Jo1*14* authorized for human food) for 8 weeks caused "I, % decrease in hepatic cytochrome oxidase activity noth sexes. The addn. of BHT to rat liver homoge- " '"Jel of 10 mg./g. liver caused a 12% decrease in oxidase activity. Thus, BUT appears to exert an ./ 11 effect on in vivo metabolism. DFJF , 'a of guanine deaminase in rat kidney, liver, ` , -during experimental uranyl nitrate intoxication. ' v/v'tic; Bastide, Pierre (Fac. Mixte Med, Pharm., 'I IK//ranGdu' anFinr-e)- deCam` inRas` eSaocc`tivBitywl(' I)1w96a6s' s1tu6d-i(e5d~6iu'> xidney, and blood of rats during exptl. intoxication with uranyl nitrate (1 ml. i.p. of a soln. contg. 2 g./l. per 100 g. body wt.). As early as 24 hrs. later a progressive elevation of I was noted in all organs, but there was a definite lowering of I in the kidney for the first 12 hrs. after the start of intoxication. Dorothy J. Buchanan-Davidson U3458u Excretion of tetraethylgermanium in the rat. Ous- trin, J.; Clavel, M. J.; Pitet, G. (Centre Rech. Toxictes, C.N.R.S., Toulouse, Fr.). C. R. Soc. Biol. 1968, 162(5-6), 122G-9 (Fr); cf. G. Pitet (1967). Et4Gc (I), a very resistant compd. in vitro, is degraded very easily in the rat. Although I has a very high b .p., it is eliminated in large amts, during respira tion. The metabolites of I found in rat urine are GeOt or the germauates. The metabolism of I is different from that of tetra ethyllead (II) or tetraethyltin (III). No evidence was found for the formation of tricthylgermanium, which explains the weak toxicity of I compared to II and III. Dorothy J. Buchanan-Davidson 113459V a-Hydroxybutyrate dehydrogenase activity of rat kidney homogenate fractions after experimental uranyl nitrate intoxication, Bastide, Janine; Bastide, Pierre (Fac. Mixte Med. Pharm., Clermont-Ferrand, Fr.). C. R. Soc. Biol. 1968, 162(8-9), 1492-3 (Fr). Most of the e-hydroxybutyrate de hydrogenase activity of the rat kidney is found in the super natant after centrifugation at 24,000 g for 2 hrs. This activity decreased with time during exptl. uranyl nitrate poisoning, whereas the contents of protein, DMA, and RNA were relatively low and underwent but little variation. C. W. Ackerson 113460p Effect of ethyl bromide on the liver. Karimullina, N. K'.; Gizatullina, A. A. (Ufim. Nauch.-Issled. Inst. Gig. ProfzaboL, Ufa, USSR). Farntakol. Toksikol. (Moscow) 1969, 32(2), 165-7 (Russ). EtBr fumes (2.4 mg./l.) inhaled by rats and rabbits for 4 hrs. daily for 6 months disrupted the func tional ability of the liver, decreased the hepatic glycogen and fat levels, and prolonged hexenal sleep. Granular dystrophy in the hepatic cells and a decreased RNA level in the cytoplasm were detected. BJJR 113461q Hemopoiesis in chronic heliotrine poisoning of Wistar rats. Levin, G. S.; Novachenko, Z. I, (Uzb. Nauch.- Issled, Inst. Gematol. Pereliv. Krovi, USSR). Farmakol, Toksikol. (Moscow) 1969, 32(2), 170-1 (Russ). Heliotrine administered s.c. at 3-10 mg./100 g. once a week for 1-8 months to Wistar rats caused hepatic lesions, hypochromic anemia, severe reticulocytosis, normoblastosis, and leukopenia. Erythro blastic sprout hyperplasia, an increased no. of mitoses, and an increased no. of reticular and esp. plasmatic cells were observed. The observed changes in the blood and bone marrow suggest development of an autoimmune form of hemolytic anemia in response to chronic heliotrine poisioning. BJJR 113462r Benzene metabolism in the liver of experimental animals and man. Tiunov, L. A.; Sokolova, T. I.; Bandman, A. L. (USSR). Farmakol. Toksikol. (Moscow) 1969, 32(2), 185-8 (Russ). The rate of CjH. metabolism during 24 hrs. of incubation was similar in liver homogenates from humans and rats, more rapid in homogenates from guinea pigs, and slower in rabbit liver homogenates. Species-specific differences seemed to be involved in CHt conversion, since the activities of aryl-4- hydroxylasc and glueuronyltransferase increased while the sulfonating system activity did not change in CtHi-treated rats. In C8Hi-treated rabbits the sulfate adcnyltransferase and aryl sulfotransferase activities decreased during disruption of the sulfonating system. The high rate of CH conversion in guinea pigs may be connected with the relatively high liver catalase activity. BJJR 113463s Effect of the sodium salt of adenosine triphosphate on experimental cyanide poisoning of rats (mechanism of the antidotal action). Mosketi, K. V.; Ganzhara, P. S. (Odess. Med. Inst., Odessa, USSR). Farmakol. Toksikol. (Moscow) 1969, 32(2), 214-15 (Russ). Na ATF (0.5 ml. of a 1% soln.) given s.c. or i.m. to rats 1 hr. prior to administration of the min, lethal dose of NaCN prolonged survival. When given s.c. im mediately after lethal cyanide poisoning it substantially extended the life span of 50% and prevented death in the other 50% of the rats. The antidotic effect of ATP may result from its ability to restore respiration by bypassing cyanide-sensitive enzymes. . BKJR 113464t Changes in the cardiac activity of rats chronically exposed to vinyl chloride vapors. Vazin, A. N.; Plokhova, E. I. (Gor'k. Nauch.-Issled. Inst. Gig. Tr. Prof. Zabol., Gonki, USSR). Farmakol. Toksikol. (Moscow) 1969, 32(2), 220-2 (Russ). Chronic (5 months) exposure of rats to vinyl chloride vapors at 0.03-0.04 mg./l. disrupted cardiac work rhythm, in duced bradycardia and arrhythmia, and reduced the relative duration of I -11 and T-II sound intervals. The relative dura tion of Uic U-T complex (in! not change significantly. Within 15 days after termination of poisoning, the rat cardiac activity rhythm returned to normal, but the duration of the I-II and T-II sound intervals remained below the initial level for another 15 days. The maximal permissible concn. of vinyl chloride apparently is significantly less than the 0.03 mg./l. level pre viously estd. BJJR X OLI 2572 70. t '*&***+* 'iRipnwmn, 85811 Chemical Abstracts Vol. 70, 1969 150 daily for 60 days increased both 0- and -/-globulin levels and de creased the albumin-to-globulin ratio; a-globulin levels were not affected. BKJR 85811b Effect of selenophene on liver and kidneys during carbon tetrachloride intoxication. Zolotarevskii, V. B.; Tugari- nova, V. N.; Miklashevskii, V. E. (Mosk. Med. Inst. im. Sechcnova, Moscow, USSR). Farmakol. Toksikol. Prep. Selena, Mater. Simp. 1967, 87-9 (Russ). Two groups each com prising 10 male rabbits (2-3 kg.) were used. All animals re ceived twice a week s.c. doses of 0.3 ml./kg. of a 40% oil soln. of CCli. To one of these groups 0.5 ml./kg. of 1% selenophene soln. was s.c. injected 2 hrs. later. During the 1st 10-12 days of CCli intoxication approx. 50% of the rabbits died in both groups. Selenophene (5000 Mg./kg. = approx. 100 as. % or 1/32 of an LD) protected kidney tissue against CCU intoxication, but dystrophic and necrotic changes of liver were more extensive and more important in animals to whom a combination of CC1< with selenophene was given. Thus, the exptl. dose of selenophene was too great and showed no protective but a destructive effect on the liver, although smaller doses of 2-3 Mg. % of Se are necessary to maintain normal liver function. Addn. of 20 pg. % of Se to the normal diet of rabbits prevented dietary liver necrosis in Ceases of hyperthyroidism. R. Pavlak 85812j Toxicology of some polymers (Povinols). Dvoskin, Ya. G.; Rakhmanina, N. A.; Dem'yanko, F, V.; Men'shikova, T. A.; Erofeeva, L. F.; Lashkina, A. V. (Nauch.-Issled, Inst. Gig. Vod. Transp., Moscow, USSR). Gig. Sanit. 1969, 34(1), 7-11 (Russ). Three samples of poly(vinyf chloride) polymers (povinols) contg. di-Bu phthalate (I), tricresyl phosphate, and chlorinated hydrocarbons as plasticizers, released I into the sur rounding air in amts, of 1.8-3.73 mg./m.1 in a sealed container and 0.53 during a single air exchange. All 3 samples had un favorable physiol, effects on exptl. animals and are not recom mended for use as finishing materials in shipbuilding. Exposure of rats to I (0.2-8 mg./m.') for 1-5 days disrupted conditioned reflex activity and nonspecific immunity, and, to a lesser extent, / the blood protein compn. and phagocytic index, and the liver wt. I-induced changes were dose-xlependcnt. BJJR 85813k Mechanism of boron effect on warm-blooded animals. Popov, T.; Angelieva, R. (Nauch.-Issled. Inst. Gig., Sofia, Bulg.). Gig. Sanit. 1969, 34(1), 78-81 (Russ). Of 60 mg. B given to rats, the distribution was approx, as follows: 50 mg. in the bones, 0.62 mg. in the liver, 0.06 mg. in the kidneys, and 0.1 mg. in the brain. The max. was reached in 12 hrs. in the liver and kidneys, after 24 hrs. in the bones and brain, B was prin cipally excreted in the urine. Complete excretion of the ac cumulated B required a long time, but the majority was gone in 2 days after reaching the max. in each tissue. John Howe Scott 85814m Effect of ascorbic acid on various signs of vanadium toxicity. Matantseva, E. I. (Inst. Gig. Tr. Profzabol., Sverd lovsk, USSR). Gig. Tr. Prof. Zabol. 1968, 12(12), 22-5 (Russ). I.v. administration to dogs (8-16 kg.) of 3, 4, or 5 mg./kg. of ammonium vanadate, or 3-11 mg./kg. of Na metavanadate in creased blood inorg. P, glucose, and lactic acid, decreased blood glutathione, and caused salivation, dyspnea, increased respira tory and heart rates, urination, and defecation. Na ascorbate, 10-50 rag./kg. given i.v. simultaneously with, or 10 min. after the administration of V corapds., alleviated or prevented the toxic and biochem. effects. One dog given 5 mg./kg. of both N ammonium vanadate and Na ascorbate died of lung edema. The severe toxicity of V compds. was attributed to increased vascular permeability and depressed glycolysis and oxidn. S. K. Vanov 85815n Comparative toxicity of tome aralkylphenols and their quaternary ammonium salts. Gadzhibalaev, A. A.; Goryaev, M. I.; Dakhno, O. V.; Kanaulova, L. P.; Potapov, S. V.; Slepushev, V. S.; Churakov, V. I.; Dozorova, A. D.; Zharkova, I. I.; Fedrushkova, I. N, (Khim.-Tekhnol. Inst., Chimkent, USSR). Gig. Tr. Prof. Zabol. 1968, 12(12), 44-7 (Russ). The phenols p- and o-hydroxydiphenyldimethyl- methane (I and II), p- and o-hydroxydiphenylmethylmethane (III and IV), the quaternary N- [8- [/3-(p-methylbenzylphenoxy )- ethoxy]ethyl]pyridinium chloride (V), and a mixt, (VI) of V and its ortho isomer had in frogs the following LDjo values: 334.9, 584.7, 329.9, 126.4 , 42.5, and 42.5 mg./kg. V and VI were more toxic, presumably because of better water soly. which permitted better absorption. In mice and frogs II or IV first caused increased motility and convulsions, then marked central nervous system depression. All other compds. caused depres sion. All compds. applied topically to the skin or in the eyes of rabbits caused local irritation, pam, and necrosis. In rabbits skin absorption was evidenced by the occurrence of toxic signs and death (in 2-3 months) after topical application of 20, 12, and 5% solns. S. K. Vanov 85816p Tolerance to lethal doses of metals in mice pretreated with low doses. Yoshikawa, Hiroshi (Nat. Inst. Ind. Health, Kawasaki, Japan). Ind. Health (Kawasaki, Jap.) 1968, 6(1-2), 88-9 (Eng). Rats were pretreated with metal ions at 10% of the challenge dose. Pretreatment decreased the mortality after challenge by Cd, Hg, In, and Pb, had no effect with Mn and Cu, and increased mortality in Fe and Zn. When the challenge rat iui was different from the pretreatment metal, Cd, Hg, In, and Pb developed cross-tolerance. D. Barbara Sankar 85817q Reversible necrosis in striated muscle fibers of the rat after severe intoxication with various cholinesterase inhib itors. Ariens, A. Th.; Cohen, E. M.; Meeter, E.; Wolthuis. O. L. (Med. Biol. Lab., Nat. Def. Res. Organ, T.N.O., Rijswijk Neth.). Ind. Med. Surg. 1968, 37(11), 845-7 (Eng). Albino, rats (200 g.) were injected i.v. with just sublethal doses of paraoxon, diisopropyl pliosphorofluoridate, or tabun, and sacri ficed at various intervals after injection. The diaphragm, intercostal muscles, gastrocnemius-soleus muscle group, and the psoas muscle were dissected, fixed in 10% formalin, and examd. histol. Local necrosis of muscle fibers is caused by the ab normally long-lasting presence of acetylcholine around the end plates. Muscle fiber necrosis may also occur in man after anti cholinesterase poisoning. R. R. Rowlands 85818r Chemical Mace: ocular effects in rabbits and mon keys. MacLeod, Ian F. (Med. School, Univ. of Michigan, Ann Arbor, Mich.). J. Forensic Sci. 1969, 14(1), 34--17 (Eng). Direct corneal contact with liquid Mace produces lasting opacities and melanosis. Spray exposure resembling that anticipated for actual use of a Mace weapon causes only transitory lesions of the face and eyes with possible sunbumlike sequellae. A Mace weapon should not be aimed directly at the face if it is discharged at less than 6 ft. The propellant does not seem to be responsible for the injuries; they seem to be due to the lacrimator, chloro- acetophenone. Irving Sunshine 85819s Cerebral amines and acute hyperbaric oxygen toxicity. Blenkam, G. Douglas; Schanberg, Saul M.; Saltzman, Herbert A. (Med. Center, Duke Univ., Durham, N.C.). J. Pharmacol. Exp. Ther. 1969, 166(2), 346-53 (Eng). Acute central nervous system (CNS) toxicity impedes treatment with hyperbaric 0 (OHP) for ischemic illness which led to a study of relations between cerebral amines and OHP-indueed CNS toxicity in rats after in jection of selected drugs. Brain levels of norepinephrine and serotonin were unchanged after 1 hr. of OHP at 4.95 atm. abs. Injection of pargyline (40-60 mg./kg.), a monoamine oxidase (MAO) inhibitor, 30 min. prior to OHP (4.95 atm. abs.) exposure for 2.5 hrs. increased (54%) the latent period before the onset of convulsions, decreased the frequency of convulsions from 92 to 33%, and increased 72-hr. survival from 20 to 59% (n = 60). Iproniazid (25-75 mg./kg.) proved equally effective; isoniazid (50-100 mg./kg.) was ineffective. Although inhibitors of norepinephrine synthesis (a-methyl-p-tyrosine, 100 mg./kg.) and of 5-hydroxytryptamine synthesis (DL-p-chlorophenylalanine. 300 mg./kg.) lowered resp. amine levels without changing OHP tolerance, the protective action of pargyline remained unaltered. Amine precursors 5-hydroxytryptophan (10-25 mg./kg.) and 3,4- dihydroxyphenylalanine (25-50 mg./kg.) also failed to alter O tolerance. The data indicate that premedication with certain MAO inhibitors can protect rats from OHP-induced CNS toxicity. These studies suggest that both the CNS toxicity in duced by hyperbaric 0 and the protection from toxicity afforded by certain MAO inhibitors are not mediated through alterations in the brain metabolism of norepinephrine and 5-hydroxy- tryptamine. RCHP 85820k Effect of Coprinus atramentarius on the metabolism of ethanol in mice. Coldwell, Blake B.; Genest, Klaus; Hughes, David William (Res. Lab., Food Drug Dir., Ottawa, Can.). J- Pharm. Pharmacol. 1969, 21(3), 176-9 (Eng). The EtOH-$o!. material extd, from C. atramentarius was more toxic to mice, as measured by the LD and potentiation of the EtOH-induced sleeping time, than the whole mushroom or the residue remaining after EtOH extn. Also, the EtOH-sol. fraction when fed to mice 4 hrs. before administration of EtOH markedly increased the blood HAc and EtOH levels. RCHQ 85821m Salivary gland regeneration after pL-ethionine poisoning. Ulmansky, Mario; Rubinow, A.; Ungar, Henry (Hadassah Med. Sch., Hebrew Univ., Jerusalem, Israel). Lr.ti. Invest. 1969, 20(3), 230-3 (Eng). After ethionine feeding, there is increased structural damage during the first 24 hrs. to^thc salivary glands of male white rats. Recovery begins in 48 ,irs- After 72 hrs., mitotic figures are apparent, and after cessation ethionine feeding for 2 weeks, morphological and histochem- indicators of the salivary glands are normal. Anna Lee Waldo 85822n Changes induced by cadmium, zinc, and lead in renal and peripheral vascular resistances in the anesthetized rabbi- Chiappino, Gerolamo; Costantini, S.; Ciria, A. M. ' Milano, Milan, Italy). Med. Lav. 1968, 59(8-9), 522-33 (H iCd at 100-500 Mg- into the jugular vein of anesthetized rablnproduced a drop in the vascular resistance of the renal arut> which decreased approx, with dose in magnitude and duratic-^ At the highest dose it was almost absent. The effect on tj-arterial system below the aortic bifurcation (measured at >-u carotid) varied. There was an increase in vascular resistance > low dosages and a slight redn. at higher dosages. Zn and Pb 11 O lil 2573 -7 7 f ~P / 7 50591 Chemical Abstracts Vol. 69, 1968 Page 47} wick, N.J.)- Can. J. Physiol. Pharmacol. 1968, 46(4), 609-16 Issled. Inst. Onkol., Leningrad, USSR). Farmakol. Toksikn- (Eng). A series of expts. has shown that the mechanisms by 1968, 31(3), 364-5 (Russ). Polyethylene polyamine (750 n:_- which the metabolism of EtOH occurs are strongly influenced by kg.) administered s.c. to rats and mice increased the hep.u the partial pressures of the 0 present in the aerating medium. monoamine oxidase and histaminase activities, decreasing For the most frequently used gas mixt., 95% 0; + 5% CO;, tyramine and histamine levels in the blood and organs of t; the EtOH consumption was abnormally large, and proportional poisoned animals. The pathol. disturbances observed in m:i, to the concn. of EtOH in the perfusate. However, when the and rats with acute polyethylene polyamine poisoning may i, system was aerated with 18% Os + 5% COj + 77% Ns, the due to the increased oxidative deamination of endogenous amiti, consumption of EtOH was similar to that found in the intact with the consequent formation of aldehydes, NHi, and H.O.. rat. The perfusate concn. of MesCO, HOAc, pyruvic acid, and BJJR lactic acid was measured in all expts. When EtOH was con 5Q598w Effect of niacin on phagocytosis in chronic trinitro sumed at these two different rates, increases in the lactic toluene poisoning. Pidemskii, E. L.; Chukichev, E, M.: pyruvic ratio and acetate levels of the perfusate were noted Mul'menko, A. M. (Perm, Univ., Perm, USSR). Farntakr.i in both types of expts. However, the utilization of glucose Toksikol. 1968, 31(3), 365-6 (Russ). Trinitrotoluene (TNT by isolated perfused liver was inhibited, and acetone levels in administered orally at 30 mg./kg. daily for 6 days to rats pro creased markedly, when EtOH was consumed at abnormally rapid gressively decreased phagocytosis. Niacin administered simul rates, although no effect was noted in the perfusate levels of these taneously at 1 mg./kg. s.c. prevented this decrease and even in metabolites when EtOH was consumed at normal rates. 27 creased the phagocytic activity of the leukocytes to 1.5-times tiie references. RCYD level in control rats. BJJR 50591p Action of beryllium ions on primary cultures of swine V 50599X Pathogenic effect of chronic exposure to vinyl chloride cells. Vegni Talluri, Maria; Guiggani, Viviana (Univ. Siena, "on rabbits. Vazin, A. N.; Plokhova, E. I. (Inst. Gig. Tr. Prof- Siena, Italy). Caryologia 1967, 20(4), 355-67 (Eng). The zabol., Gorki, USSR). Farmakol. Toksikol. 1968, 31(3), 369- effect of Be++ poisoning on mitosis and morphology of swine 72 (Russ). In rabbits exposed to vinyl chloride (9-10 mg./I. kidney cell and lymphocyte cultures was studied. Treatment air) for 4 hrs. daily for 5.5 months altered 5-waves (frequency with Be++ had a harmful effect on all the mitotic phases and >80 Hz.) appeared on the electroencephalogram from the an- abnormality of chromosomes was frequent. At high conctts. terior hypothalamic nuclei, and the potentials of the anterior the action of Be** was less pronounced on kidney cells than on and posterior nuclei increased by 18-30 and 70-85%, resp., over lymphocytes. Be++ exerts its toxic action by competition control values. Concomitant changes in the cardiovascular sys with Mg++ either in the activation of DNA polymerase or in tem (bradycardia, arrhythmia, decreased voltage of the in the binding of DNA to histones. L. Mirone dividual electrocardiogram peaks or whole complexes, decreased 5Q592q Protective effect of ethyl alcohol towards ally] alco duration of systole, increased arterial pressure, and retarded hol-induced hepatic lesions. Schwarzmann, V.; Infante, R.; blood flow) also occurred. The functional changes m the an Raisonnier, A.; Caroli, J. (CHU Saint-Antoine, Paris, Fr.), terior and posterior hypothalamic nuclei may have a role in the C. R. Soc. Biol. 1967, 161(12), 2425-9 (Fr). A 90-min. per pathogenesis of toxic angioneurosis due to vinyl chloride. fusion of isolated rat liver with blood contg. allyl ale. (0.018 ml./ 180 ml.) caused a release of lactic dehydrogenase, malic dehy BJJR 50600r Brown FK. HI. Administration of high doses to drogenase, and glutamic-pyruvic transaminase into the perfusate rats and mice. Grasso, P,; Gaunt, I. F.; Hall, D. E.; Gotberg, and a simultaneous depletion of these enzymes from the liver; L.; Batstone, Elizabeth (Brit. Ind. Biol. Res. Assoc., Carshal- ale. dehydrogenase and glutamic dehydrogenase activities ton, Engl,). Food Cosmet. Toxicol. 1968, 6(1), 1-11 (Eng). were not detected in the perfusate and were not decreased in the Acute oral toxicity studies with Brown FK gave LD values >2 liver. Biliary secretion was irreversibly arrested after 18-20 g./kg. and 8 g./kg. in mice and rats, resp. The values for i.p. min. of perfusion, and hepatic lesions occurred. A 20-min. per injection were 1.5-2 g./kg- in mice and 0.75-1.15 g./kg. in rats. fusion with blood contg. EtOH prior to the treatment with allyl When repeated daily oral doses ranging from 0.1 to 2 g./kg, were ale. prevented the enzyme release, the hepatic lesi ns and the given to rats, a precipitous wt. loss and a vacuolar myopathy effect on biliary secretion, and did not cause the release of ale. of the heart and skeletal muscles accompanied by lipofuscin dehydrogenase or glutamic dehydrogenase activities. BPJF formation occurred with doses of 0.5 g./kg. and over. At the 50593r Effect of ethanol on hepatic metabolism and enzyme highest dose employed (2 g./kg.), there was also hepatic centri- activities. Nelson, Patricia Ann (Indiana Univ., Blooming lobular necrosis and renal tubular degeneration Pretreatroent ton, Indiana). 1967, 104 pp, (Eng). Avail. Univ. Microfilms, with antibiotics reduced the incidence of muscle lesions. Re Ann Arbor, Mich., Order No. 68-7228. From Diss. Abstr. B peated i.p. injection did not have any effect on the heart or skeletal 1968, 28(11), 4688. SNDC muscle. Only 2 of the 6 components of Brown FK. 2,4-diamino- 50594s Energy-linked calcium transport in liver mitochondria 5-(p-sulfophenylazo)toluene (I) and l,3-diamino-4-(p-su!fo- during carbon tetrachloride intoxication. Carafoli, Ernesto; phenylazo Jbenzene (II), produced muscle damage after repeated Tiozzo, Roberta (Univ. Modena, Modena, Italy). Exp. Mol. oral doses of 0.5 g./kg. Comparable doses of mixts. contg. the Pathol. 1968, 9(1), 131-40 (Eng). In rats intoxicated by the gas Other components as well as I or II were considerably less toxic. tric intubation of 0.5 ml. CCU/200 g., CaI+ concn. in liver mito After daily oral doses of 1 g./kg., muscle lesions were found in chondria increased --10-fold within 18-20 hrs. However, i.p. rats, rabbits, and guinea-pigs, but none were seen m mice or injected uCa was not taken up by hepatic mitochondria in in hamsters. The results suggest that the intestinal micoflora is toxicated rats as rapidly as in normal animals. In vitro, hepatic responsible for the breakdown of the components of Brown FK mitochondria from CCL-intoxicated rats did not show increased to toxic products. Variations between species and between ani Ca*+ uptake, but Ca,+ release induced by oxidative phosphoryla mals of the same species may be due to qual. and quant, dif tion uncouplers was greatly decreased. This suggested that in ferences in the intestinal microbial population. RCNP CCU intoxication, the balance between ADP phosphorylation and Ca*+ uptake is shifted in favor of the latter, thus contribut ing to the accumulation of Ca,+ in mitochondria. DD JN 50595t Protective effects of alpha-tocopherol on the hepato- 50601s Brown FK. TV. Cytopathic effects of Brown FK on cardiac and skeletal muscle in the rat. Grasso, ?.; Muir, A.; Golberg, L.; Batstone, Elizabeth (Brit. Ind. Biol. Res. Assoc., Carshalton, Engl.). Food Cosmet. Toxicol. 1968, 6(1). 13-24 toxicity of carbon tetrachloride: an electron microscope study. (Eng). Administration of 2 or 3 massive (1 g./kg.) oral doses Meldolesi, Jacopo (Inst. Pharmacol., Univ. Milan, Milan, Italy). of Brown FK to rats induced a myopathy in cardiac and skeletal Exp. Mol. Pathol. 1968, 9(1), 141-7 (Eng). The oral administra muscles characterized by multiple vacuoles ~l-2 a m diam. tion of 2.5 ml./kg. CCUdild. 1:2 with liq. paraffin to rats produced Ultrastructurally, these consisted of areas of fibnllolysis, af severe hepatic lesions within 24 hrs. However, liver damage was fecting initially the A-band. Histochem., the myopathy was markedly reduced in rats i.p. injected with the lipid antioxidant, accompanied by a moderate increase in acid phosphatase activity a-tocopherol succinate (125 mg./kg.), before CCU administra and by a loss of phosphorylase activity. Subsequently, complete tion. This suggested that lipid peroxidn. is the primary mecha lysis of the affected fibers ensued. In the heart, lysis was fol nism of CCU hepatotoxicity. 27 references. DDJN lowed by macrophage invasion and fibroblastic proliferation, 50596u Distribution and toxicity of aliphatic hydrocarbons in and in skeletal muscle, by regeneration. The occurrence of body tissues. Shugaev, B. B, (Yaroslav. Med, Inst., Yaroslavl, lipofuscin in muscle fibers and in macrophages was scanty and USSR). Farmakol. Toksikol, 1968, 31(3), 360-3 (Russ). Gas erratic. When Brown FK was given in the diet at a level of 2%, chromatog. was used to study the distribution of 6 volatile hy fibrillolysis and an increase in the no. and electron d. of lyso- drocarbons in the mouse and rat body tissues. The volatile somes was observed ultrastructurally during week 2-3 of the hydrocarbon content of the brain and parenchymatous organs test. These changes were accompanied by a marked elevation was similar, but the level in the fatty tissue was significantly of histochem. demonstrable acid phosphatase. Progressive higher than in the brain, liver, kidneys, or spleen. There was a deposition of lipofuscin was the principal pathological feature parallel between the toxicity and effective cerebral concn, of iso- during week 3-12. Initial damage to the A- and I-bands in both prene, divinyl, and isobutylene, but not of butane, 2-meyhylpsnt- cardiac and skeletal muscle distinguishes the Brown F K myop 1-ene, or 2-methylpent-2-ene. The divinyl concn. was higher (n athy from that known to be produced by high doses of corti the medulla oblongata than in the cerebellum or cerebral-cortex. costeroids, thyroxine, chloroquine, or plasmocid, from ischemic BJJR damage and from muscle damage resulting from deprivation of 50597v Some biochemical changes in animals following acute K, Ca, or Mg. The lysosomal changes and accumulation of polyethylene polyamine poisoning. Soloimskaya, E. A. (Nauch.- lipofuscin are suggestive of primary lysosomal damage which ,, :t61 14--Toxicology wliicli are analogous to those observed in individuals Vladimir Kostka s)5o: Mammalian Pathological Biochemistry, Section 12. ,i'mhcsis of rat immunoglobulins--cell-free system for Aviithrsis prepared from lymph-node microsomal vesicles I'lgoSSj. Immunochent. studies on Salmonella--detn.of 1 of specific polysaccharide of Salmonella Strasbourg, "p Salmonella (Sect. 2) 16799f. Topochem. arrangement , jaisidcs in erythrocyte membrane (Sect. 2) 18808h. \>r.ithc study of reaction of heparin with hexammine cobalt k and lysozyme (Sect. 2) 18724c. Ascorbic acid oxidase ,1 from different plant materials (Sect. 3) 19064Z. Effect ' ' ,.,u,.lC prepn. on protein fractions of immunized animal ' : - i,sect. 4) 19263p. Changes in body compn. during long- ". in.itnicnt with cortisone and anabolic steroids in asthmatic ' - i-cij fSect. 4) 191881. Simplified batch method for isolation i) cuproteins from normal and pathological serums and ", j-J i.'tcft. C) 19409r. Biol, activities of polyclectrolyticaliy "it macromols. (Sect. 8) 19711h.-'Immunoelectrophoretic uni? of antigenic components of Bacillus megaterium (Sect. Vol, 68, 1968 20560 S) 19757c. Sepn. and characterization of sol. adenovirus type 9 components (Sect. 8) 197l6p. Structure and kinetics of forma tion of antibody in turtle (Sect. 9) 19946p. Difference in pro teolytic activity of spleen cells of young and immunologicatly mature rabbits (Sect. 11) 20213d. Corticosteroid-binding globulin--biochemistry, physiology, and phylogeny (Sect. 11) 20107*. Detection of embryo-specific globulins in serum of embryos and fullterm human infants (Sect. 11) 20150f. Com parative immunoglobulin detns. in human serum (Sect. 11) 20178w. Sensitivity to some fungal allergens during penicillin prepn. (Sect. 14) 20587d. Role of histamine in production of immediate reactions of wheal and angioneurotic type (Sect, 15) 20854p. Effect of some ganglion-blocking prepns. on develop ment and course of anaphylactic shock (Sect. 15) 20830c. In fluence of chloramphenicol in immune reactions in rats (Sect. 15) 20806Z. Methodology and trends in study and prevention of air pollution by chem. allergens (Sect, 59) 15779p. Antigen with nucleoside determinant (Sect. 63) 16099d. Fractionation of significant quantities of biol. active prepns. by prolonged pre parative paper electrophoresis (Sect. 2) 18711 w. Response of lymphocytes to penicillin; comparison with skin tests and circu lating antibodies in man (Sect. 15) 207061. 14--TOXICOLOGY T. a. TOKKBLSON KMCq Chemical analysis of aflatoxiii. R. Monacelli and , *M. Manzone (Inst. Super. Sanita, Rome). Ann. 1st. Super, J(l't. 3-4), 316~26(1907)(Ital). A review with 23 refer- ,, ,, Antonio A. Rizzoli ;:5<7r Toxicity of mercury vapor. G. A. Neville. Can. Educ. 3(1), 4-7(19G7)(Eng). A review is given of Hg ..4i uy, covering its history, threshold limits, mode of absorp- ,, r. ,iid distribution, and treatments for Hg poisoning. 33 i-.--miccs. CRJN Fluorocarbon toxicity and biological action. J. Wes- n Jl.iyton, Jr. (E. I. du Pont de Nemours and Co., Wilming- -. Del.). Fluorine Chem, Rev, 1(2), 197-252(1967)(Eng). ri tensive review summarizes the known toxicology of the i- oultanes, the fluoroalkcnes, and the ffuoropolymers, and dis- -4-ws various aspects of their biol, action. Much more in- rsjiinn is needed on the mechanism of action of these sub- tixors. Understanding their mode of action in relation to their >sm. constitution should be a governing factor in further in* ^ot-gaiions of fluorocarbon toxicity. 57 references. M. M. Judge 2S549t The effect of fluorides on livestock, with particular dittnte to cattle. James L. Shupe and Ernest W. Alther ' A. Ayr. Res. Serv., Logan, Utah). Handbuch Exp. Pharma- JOil), 307-54(1966)(Eng). A review of the effects of i*. talcs on sheep, swine, horses, turkeys, and, esp. cattle. The Jtr'i of fluorosis in cattle on teeth, bones, hair coat, skin, *<m, salt tissue, kidney, liver, reproduction, blood, placental vv-.tltr, milk production, digestion, metabolism, and enzymes "'t discussed. A comprehensive guide for diagnosing and "Minting fluorosis was given. 89 references. ^ Patricia W. Heenan --liOm The mammalian toxicology of organic compounds 'ttiming fluorine. J. Wesley Clayton, Jr. Handbuch Exp. '".4*0/. 20(1), 459-50Q(1966)(Eng). A review of mara- **jJa lexicology, history, and uses of fluorocarbons, including - wussion of the toxicology of fluoroalkanes, fluorocyclo- wa.rs, fluoroalkcnes, fluoroalcohols, and fluoroaromatic their acute and chronic inhalation toxicities, acute oral, as, itt eye toxicities, and their biol. activities. 72 references. w Patricia W. Heenan -'Sin Botulism. Anton Skulberg (Forskningsutvalget ;rfv?r-, Oslo, Norway). Norsk Pelsiyrblod 41(8), 259-61 ot 1 ^orweg), A review of the subject in connection with c;1ses of poisoning of mink in Telemark, Norway, due to "rutium] botulinum toxin in the mink feed. ,, Valborg Aschehoug otul*sm in mink. Steinar Hauge, Anton Skulberg, ` .Grini (Norges Veterinaerhoegskole, Oslo, Norway). ,, ,j ` Asdyrblad 41(18), 510-ll(1967)(Norweg). A review ,, '"uject in connection with the recent cases of poisoning in n \ w'*h Cllostridium botulinum in Telemark and AustNorway. As mink is an animal very sensitive to C. *""> toxin, vaccination of the puppies should be recom- " a prophylactic means. Valborg Aschehoug Short term chemical danger. Georges Le Moan I1"*"-. Paris). Pharm. Ft. 1967(15), 499:504(Fr). '' given of the hazards of explosion, poisoning, etc., . ihe precautions that should be taken against them. >.George M. Hocking *4 ,`j / "*ttrotoxicity of anticholinesterase agents. An- - i' ',c of various centrally acting drugs. G. Bignami L. Gatti (1st. Super. Sanita, Rome). Proc. Eur, Soc, Study Drug Toxicity 8, 93-106{1967)(Eng). The report sum marizes the behavioral effects of anticholinesterases, and evalu ates the usefulness of behavioral methods for toxicological in vestigations with Para-oxon, parathion, Chlorthion, Systox phosphamide, physostigmine, and galanthamine. 45 references. P. S. Sarin 20555s Neurotoxic side effects of certain organophosphorus compounds. W. N. Aldridge and J. M. Barnes (Med. Council Labs., Carshalton, Engl.). Proc. Eur. Soc. Study Drug Toxicity 8, 162-8(1967)(Eng). A review of delayed neurotoxic effects of some organophosphorous anticholinesterases. 20 references. Jenifer A. Edwards 20556t Biochemical and physiological causes of the toxicity of alcohol. Ryszard Wiktor Schramm and Halina Schrammowa (Univ- A. Mickiewicza, Poznan, Poland). Psychiat. Pol. 1(3), 343-7(1967)(Pol), A review with 47 references, Y.Pomeranz 20557u In vivo deiodination of Rose BengBl-u>I in rats after administration of CCU. H, Bergner (Humboldt-Univ., Berlin). Acta Bid. Med. Ger. 16, 294-9(1966)(Ger). About double the amt. of ulI*Iabeled Rose Bengal was deiodinated in vivo in rats intoxicated by 0.1 ml. CCL/lOO g. as compared with con trols. With a protein-free diet, the effect was smaller and could not be detected after 6 days. From CZ 1967(30), Abstr. No. 1564. MZCR 20558v Effect of acute and chronic hepatitis and of fatty liver degeneration on erythropoiesis. B. Sari, S. V. Kirilina, Sh. Dan, and L. Oros. Acta Corn. Med. Inlernae Hung., 3rd., Budapest 1965, 923-8(Russ), Rabbits were orally given 3 doses of 0.25 mg. CClj/kg. and then i.m. 3 doses of 15 mg. phenyl- hydrazine (I)/kg. Consequently, plasma enzymes (alk. phos phatase, aldolase, glutamic-oxalacetic transaminase) increased, but erythrocyte enzymes did not change or slightly decreased. After a few days, serum enzymes normalized and administration of I did not further alter their level. At the same time, erythro cyte enzymes increased in activity due to I and the increase was correlated with the no. of reticulocytes. Later, these enzymes normalized as well, with the exception of glucose-6-phosphate dehydrogenase and aldolase, whose increase outlasted normaliza tion of the reticulocytes, indicating the presence of a large no. of young erythrocytes in the peripheral blood. These changes were similar to those in erythrocyte enzymes in animals given only I without CCL; it is concluded, therefore, that a slight acute injury to the liver does not affect erythropoiesis. Chronic injury decreases erythrocyte survival time and accelerates erythropoiesis. M. Kalab 20559w Poisoning with organic mercury compounds in the Niigata prefecture along the Agano river. I. Detection of methylmercury compounds in hair of patients by gas chromatog raphy. Yukio Takizawza and Takao Kosaka Fak., (Med. Univ. Niigata, Japan). Acta Med. Biol. (Niigata) 14(3), 153-61 (1966)(Ger). Eight patients exhibited poisoning attributable to organomercury compds. Hair from the patients was treated with detergent, water, HC1, CHC1, and dithizone before anal, by gas chromatog. was carried out with a Shimazu GC-lC app. with electron capture detector (ECD-IA) with the conditions: column 1.5 m., inner diam. approx. 3 mm.; column temp. 190-5; 15 or 25% diethylene glycol succinate on 60-80 mesh Shimalite; N carrier gas at 35 ml./min.; detector temp. 200; sample size 0.5 p\. Sepn. of methyl-, ethyl-, and butylmercury chlorides was achieved with the ECD-IA detector, but not by flame ionization. D. S. Plaut 20560q Characterization of subtle toxicity of certain plastic Jx, O LI 2575 ,1*^. i t f 1 i -< i I i I i 10 t> in oi H o ---tYrr 20561 Chemical Abstracts Vol. 68, 1968 Page r i components used in manufacture of the polyvinyls. W. L. Guess, Sol Haberman, D. F. Rowan, R. K. Bower, and John Autiao (Univ. of Texas, Austin). Amcr. J. Hasp. Pharm. 24(9), 494-501(19G7)(Eug). The techniques useful in detecting the subtle toxicity of some ingredients used in the mamif. of poly(vinyl chloride) plastics, used in the production of containers and closures fqr certain biologicals, are discussed. Methods of detection include tissue culture tests, animal expts., and effects on antibody reactions and on washed blood cells. Certain heat stabilizers showed a marked incompatability with the biol. systems used. Reactions with 5 plastisizcrs were more subtle. The results suggest the need for further research into the relations between various levels of toxicity and potential harm in humans. H. M. Burlage 20561r Some chemical aspects concerning the occurrence of ailatoxin in foods and feeds. W. D. Raymond (Trop. Prod. Inst., London). Ann. 1st. Super. Sanila 3(Pt. 3-4), 289-300 (1967)(Ital). This paper reviews various aspects of the problem aflatoxin in foods and feeds. The agricultural, mycological chem., anal., biochem,, toxic, com., and public health aspects of the problem are discussed. The presence of mycotoxins in foods and foods also is summarized. 47 references. Katherine H. Fisher 20562s The effect of diet on carbon tetrachloride metabolism. A. A. Seawright and A. E. M. McLean (Med. Res. Council Labs., Carshalton, Engl.). Biochem* J. 105(3), 1055-60 (1967)(Eng). Blood and liver concns. of CCL were measured at intervals after an oral dose, in rats given stock and protein* free diets. The values did not correlate with the resistance to poisoning found in the rats given protein-free diets. Metabolism of CCl, to CO, in vivo and in liver microsomal prepns. was de pressed in animals given protein-free diets. Rats given a single dose of DDT are highly sensitive to CC1, poisoning. The livers of such animals had an increased microsomal protein content and greatly increased microsomal activity in the demethylation of Pyramidon and in the conversion of '*CCI, into uCO,. The incorporation of leucine-14 C into protein by liver slices is de pressed by CCl,. This effect is decreased by the addn. of SKF 525A and in slices from rats given protein-free diets. It is suggested that the toxicity of CCL is closely linked to its metabo lism. RCFG 20563t An attempt to influence the collagen defect in ex perimental lathyrism. K. Tmavsky, Z. Trnavska, B. Skrovina, and L. Cebecauer (Res. Inst. Rheumatic Diseases, Piestany, Czech,). Biochim. Physiol. Tissu Conjonctif, Conf. Commun. SymP. Int., Lyon 1965, 663-70(Pub. 1966)(Eng). To study the influence of hydrocortisone (I) and Na salicylate (II) on the soly. of collagen proteins and on changes in the epiphyseal growth plates in lathyric rats, exptl. lathyrism was induced in 36 male rats by feeding a 60% conen. of sweetpea seeds (Lathyrus odora- tus) for 30 days. Twelve of these rats were simultaneously treated with I (10 mg./kg. body wt. daily), i.m.; another group of 12 were treated with II (250 mg./kg. daily), i.p. The 3 exptl. groups were compared with 3 nonlathyric control groups treated similarly. After 30 days, total hydroxyproline (III), dialyzable III, and acid-sol. Ill were detd. in dorsal skin exts. For histol. evaluation, the tibial growth plates from decalcified bind limbs were microscopically examd. Total III was not significantly changed in any of the groups studied. I in intact (control) animals resulted in decreased levels of the neutral salt- sol. Ill and dialyzable III. II had no effect on the sol. fractions. Feeding with sweetpea increased the neutral and acid sol. Ill; the greatest part of the lathyric neutral sol. fraction being dialyzable. In lathyric rats, 1 treatment depressed the elevated amts, of sol. Ill as well as dialyzable III. Even more effective in restoring normal conditions in lathyric rats was II treatment. Histol., the cells of the epiphyseal plate in lathyric animals showed elevated mitotic activity but delayed maturation. The synthesis of ground substance in the intercellular spaces was also disturbed with demasked collagen fibers, granular decompn., and some cystic areas. I depressed lathyric toxicity, while II restored the tibial growth plate to nearly normal. 19 references. L. K. Alien 20564u Toxicity of 1,2-dichloroethane-extracted fish protein concentrate. I. C. Munro and A. B. Morrison (Food Drug Res. Labs., Dept. Natl. Health Welfare, Ottawa). Can. J, Biochem. 45(11), 1779-81(1967)(Eng); cf. CA 67; 52842d. Wistar rats were fed a protein-free diet with 50% protein from iyophilized or extd. cod fish (Iyophilized cod extd. for 24 hrs. with iso-PrOH or 1,2-dichloroethane (I), then heated for 2 hrs. at 60 in vacuo) which contained 40 mg. % chiorocholine chloride (II;. Cod fillets extd. with I were toxic to the growing rat. The toxicity was not due to II but was coned, in a McOH ext. of the I-treated fish. However the MeOH-extd. fish did not support growth even when supplemented with cystine and histidine. Dorothy J, Buchanan-Davidson 20565v Significance of carbon monoxide from cigaret smok ing inside a car. Milan Srch (Karlova Univ., Hradec-Kralove, Czech,). Deut, Z. Cesamte Gcrtchtl. Med. 60(3), 80-9(1967) (Ger). A forensic opinion from the author was needed in the case of a 30-year-old woman who had died in a closed car - . a garage. In a test on 4 persons, 2 of them smokers and 2 smokers, who sat in a closed car with a cubaturc of 2,IG and smoked 5 cigarets with inhalation during 60 min,, the ' hemoglobin conen. in the blood of the smokers rose from 10%, that in the blood of the non-smokers from 2 to 5%. such circumstances a fatal intoxication was deemed not po- Consequences for traffic safety are discussed.' D. H. Stni,- 20566w Histoautoradiographie studies on mesenchymal . duet cells of thioacetamide-induced cirrhosis of the liver in no- Balthasar Wohlgemuth (Kari-Marx-Univ,, Leipzig, Gi- Exp. Pathol. 1(1), G4-71(1967)(Gcr). White mice (19-21 were fed 0.25-0.45 mg. thioacetamide (I) in the drinking w:.t Controls without I were treated further by the same proced-.;:. After 70 days the animals were injected i.p. with 3 gci. of Un dine body wt. After this the animals were k.; and the livers were fixed in HCHO; sections (5 g) were win with inactive II to remove unincorporated II-'H, and autor.i grams were exposed for 4, 6, 8, and 19 days at 15. After days the development of cirrhosis had proceeded widely m treated animals. The parenchyma was penetrated by mien, and collagenous fibrillar structures as well as with mesenchyr and duct cells, which increased in relative no. The incorpM tion rate of II-'H into hepatoeytes increased from 0.03 (contr- to 0.24% in exptl. animals; in Kupffer's cells the resp. labi-i- indexes were 1.67 and 2.41%. Labeling of hepatic capsule .. endothelial cells or of the bile duct epithelium showed no ference between controls and I-treated animals. The duct c- exhibited a labeling rate similar to that of Kupffer's cells u: . treated animals. As early as 1 hr. after II application, blacker, mitotic figures could be seen in Kupffer's cells, both in contr and in I-treated animals. A possible shortening of the phase due to unexplained reasons was considered. 34 referenct , E. Talafan; 20567x Histamine level and histamine fixation in the br_ tissues and skin in rats under the effect of industrial poiscr.. R. S. Eizengart (Sanepidst., Moscow). Farmakol. Toksm 30(5), 608-9(1967)(Russ). Homogenates from rat brain a from rat skin were tested chromatographicaily for histanv conen. and histamine fixation after rats had been exposed citl . to -threshold concns. or to toxic doses of methylcyciohexa-. ethylene sulfide, diethyiaminoethyl mercaptan, or 2-methyi- vinylpyridine. At threshold levels there was less histarn fixation in skin and more in brain tissue. After toxic dost the changes were irregular both in conen. and in histanm fixation. Julian F. Smith 20568y The toxic peptides of Amanita phailoides. Theoo- Wieland (Gsethe-Univ., Frankfurt/M., Ger.). Fortschr. Chr- Org. Saturst. 25, 214-50(1967)(Eng). A review is given; fa; mushroom poisoning is almost exclusively attributable to me. bers of the genus Amanita. Their toxins are completely a sorbed from the gastrointestinal tract, while their action - primarily on the liver; no specific therapeutic agent is known present. Thus, the understanding of the chem. structures a: i the mechanism of the action of the toxins is of great importan from the therapeutic standpoint. Isolation of the toxic r gredients, the chem. structure of the toxic peptides, the pli loidin and the amanitin group, and synthetic expts. with am/ acids and cyclopeptides are covered. 86 references. CSJN 205692 Comparative toxicity of mercaptobenzimidazole a.-., its zinc salt. N. V. Mezentseva. Gig. Olsenka Khim. Fakti" Vnesh. Sredy 1966, 119-20(Russ). Mercaptobenzimidazole 1 and its Zn salt (H) were studied in acute (mice), subacute (rat and chronic (rabbits) expts. LD internally for mice was 12 for I and 737 mg./kg. for II. The animals were exposed u and H dust for 2 hrs. daily for 15 days in concns. of 400 mi m,` A lag in wt., increase in the content of amino N in i < urine, and disturbances in the nervous system were observe- Morphological alterations were found only in the lung tissue (pi1 bronchitis with slight atrophy of the bronchial mucosa), chronic expts. on rabbits I caused disorder in the protein-tor- ing function of the liver. II increased the lipid content in ' blood, I increased the aldolase content, and II decreased ' - cholinesterase activity of the blood. I decreased the erythroc; count in the blood to 20,000. A proliferative reaction was (ou. in the lungs; edema and fatty dystrophy were observed in ; liver, and punctate hemorrhages were observed in the my cardium. II caused slight edema in parenchymatous orga' I had no irritating effect on the skin or mucosa of the ev whereas II caused moderate irritation. From Kef. Zh., Furor. Khimoterap. Sredsia. Toksikol. 1967, Abstr. No. 7.54.831. . MVR 20570t Methods for the qualitative and quantitative termination of aflatoxins. E. H. Marth (Univ. of Wiseon- Madison). J. Milk Food Technol. 30(10), 3^.7--20( 19GTKlx'- Qual. and quant, measurements of aflatoxins-by -means of tli layer chromatog. can be improved by substituting a den-n metric "reading" of the thin-layer plates for visual exam Examn. of small samples (down to 0.3 mg.) can be accompfi'-1^ by a thin-layer chromatog. procedure which employs a MeA' 1699 Chemical Abstracts Vol. 68, 1968 ' Psg* 148 oxidn. of DPNH which results from ale. metabolism inhibits oxidn. of fatty acids', acetyl-CoA generation, and subsequently gluconcogcucsis. 24 references. FHJX 1699a Determination of the toxicity of quercimeritrin, its aglucone, and the amount of flavonoids obtained from cotton flowers. D. E. Tuniyants and L. A, El'kind (Tashkentsk. Cos. Mcdinst., Taslikcnt). JJokl. Akad. Nauk Uzb. SSR 24 (8), 50-l(19G7)Wuss). The toxicitics of quercetin 7-glucosidc (I), its aglucone quercetin (II), and flavonoids (III) extd. from cotton flower (108-F) were studied in 5 groups of 6 mice. Prepns, were given perorally in 1 ml. of distd. water daily for 12 days. II was administered in a dose of 1 g./kg. body wt., doses of 1 and III were not given. The av. increase in wt. was detd. Then the animals were decapitated and internal organs were studied histol. No morphological changes were noted m the brain, lungs, heart, stomach, pancreas, liver, kidneys, adrenal glands, and gonads of animals administered I, II, or III, except protein dystrophy observed in the liver and adrenal gland cortex tone of some cxptl. as well as control animals. F. Vitek 1700u Effect of small concentrations of thiophene and chloro- isocyanates on the ascorbic acid content in rat organs. X. N. Pushkina, I. A. Zibircva, and Sh. S. Khikmatullaeva (Inst. Obshch. Kommun. Gig. im. Sysiua, Moscow). Gig. Sanit. 32(10), 103-5(1967)(Russ). Inhalation of thiophene (3 or 20 ing./m.1), p-chlorophenylisocyanate (0.03" mg./m.1), or m- chlorophenyhsocyanate (0.1 mg./m.') by rats over an 80-day period decreased the adrenal, kidney, liver, and brain ascorbic acid (vitamin C) levels. This decrease was accompanied by dehydroascorbic acid and diketogulonic acid accumulation in the liver and increased urinary excretion of 17-keto steroids. BJJR ]701v An experimental study in dogs on the usefulness of mannitol, fursemide, and methyl phenidate in phenobarbital intoxication. S. V. Gokhalc, K. K. Gudibanda, D. G. Patel, and U. K. Sheth (Seth G. S. Med. Coll., Bombay). Indian J. Med. Res. 55(10), 1107-20(1967)(Eng). Acute intoxication by phenobarbital (I) (100 mg./kg,, i.p.) was studied in dogs. One hr. after I, i.v. infusion of 20% mannitol (II) (375 ml. in 110-30 min.) or i.v. injection of fursemide (III) (20 mg.) in creased the I excretion to 13.58% and 5.8%,Tesp., as compared to 1.78% of the injected dose in controls. A combination of II and III did not act synergistically. II (20%) in 3 infusions of 375 ml. interspersed with isotonic saline (500 ml.) caused an excretion of I of 47.7%. Saline alone was less effective than II. Methyl phenidate, 10 mg./kg. i.v. 1, 3, and 5 hrs. after I in creased the urinary excretion to 5.2%. This was thought to be due to high blood pressure and hyperventilation produced by methyl phenidate. 27 references. FHJX 1702w Toxicity of dimethyl sulfoxide (DMSO) to fish. Wayne A. Willford (Bur. of Sport Fisheries & Wildlife, La Crosse, Wis.). Invest. Fish. Contr. No. 20, 8 pp.(1967)(Eng). Toxicitics of DMSO to rainbow trout, brook trout, lake trout, carp, black bullhead, channel catfish, green sunfish, bluegill and yellow perch were detd. in 24-, 48-, and 9G-hr. static bioassays at 12. Toxicity was observed around 30 parts/thousand and was not seriously affected by water quality, although increased temp, increased the toxicity to rainbow trout. A preliminary test indicated that DMSO has little effect on the toxicity of antimycin to bluegill. S. Allen 1703x Accidental organic phosphorus poisoning: the use of propranolol to counteract vagolytic cardiac effects of atropine. A. Valero and D. Golan (Med. Dept. B, Rambam Govt. Hosp., Haifa). Israel J. Med. Set. 3(4), 582-4(1967)(Eng). The shortening of the time for coronary filling caused by the excessive tachycardia resulting from atropine administration after org. P poisoning has serious deleterious effects on the heart in the presence of hypoxia. The patient, a young healthy woman, demonstrated electrocardiogram changes after one day. of sinus tachycardia at 150-180 bcats/min. Shortly after injection of 5 mg. of propranolol, the electrocardiogram reverted to normal. This procedure was extremely safe, even in the presence of heart disease. Independent of the slowing of the heart rate it is thought that propranolol also has specific antiarrhythmic action, making this drug dually beneficial in counteracting the vagolytic effects of atropine and in guarding against ventricular fibrillation. Mahmoud A. Fayez I704y Organic phosphate intoxication. Wendell L. Fair banks and Kenneth C. Hoffman. Xeb. State Med, J. 52(S), 376-9(19G7)fEngl. A discussion of 2 cases of or.;, pio qd'ate poisoning, emphasizing the role of cholinesterases in resistance and of atropine and the oxime drugs in treatment. The mecha nism of toxicity and the rationale of treatment are detailed. William F. Bruce 1705z Histological and histochemical aspects of th{ morpho logic alterations in the heart muscle caused by alcoholic in toxication. V. I. Yakovleva (Xauch.-Issled. Inst. Sudebnoi Med., Moscow). Sudebno-Med. Eksperttza, Mm. Zdravookhr. SSSR 10(3), 25-30(19G7)(Russ). Morphological alterations in the heart muscle of 8 persons who had died from ale. intoxica tion and 16 persons who had died from atherosclerosis and ale. intoxication (2-3% ale. in the blood) were studied histol. and histochem. An increased size and wt. of the heart caused by a complex of pathoi. processes was noted in persons with ale. intoxication. A damaged permeability of blood vessels and stromal edema connected with the accumulation of acid muco polysaccharides, protein, and fatty myocardium dystrophy were observed. N. Mastalir 1706a Toxicity profiles of vinyl and polyotefinic plastics and X their additives. Wallace L. Guess and Sol Haberman (Coll, of Pharm., Univ. of Texas, Austin). Tech. Pap. Reg, Tech. Con/., Soc. Blast. Eng., N.Y. Sect. 1967(Sept.)f 15-23(Eng). Plastics were implanted into rabbit muscle tissue by cutting slivers of plastics into sections 1 mm. X 1 cm. These sli'-crs were placed in a hypodermic needle and inserted into the para vertebral muscle of anesthetized rabbits. One week later the rabbits were sacrificed and the implantation sites examd. for evidence of a histopathol. tissue reaction around the plastics. A cell culture technique was also used (C.4 62: 9G72c; 63:16545c). Exts. of plastics were prepd. by extg. for 24 lirs. in a Soxhlet app. using 95%, EtOH; the ale. was removed by gentle heat m vacuo and the residue was reconstituted with normal saline. These exts. were, then evaluated by mouse i.p. injection, rabbit intradermal injection, cell culture techniques, and hemolysis liability to a 2% suspension of washed red blood cells. Ale. extns. of one of the polyvinyl chloride (I'VC) resins revealed that the supposedly pure PVC resin contained an av. of 3.5% extractable material, which appeared to be a waxy-like semi solid material. Some of this material was pushed through a needle into the muscle of a rabbit and gave visible necrosis and microscopic eosinophilia after 1 week. Two different lots of PVC resin contained toxic material which was leachablc into a biol. system and an extreme eosinophilic response was noted. A large group of cliem. agents (17 phthalates, 5 scbacates, 6 adipates, 7 citrates, and 9 miscellaneous compds.) currently being used or having potential use in various plastics formula tions were investigated for toxic potential. As a group, the stabilizers showed the greatest degree of toxicity and if these were used in conjunction with a plasticizer in a plastics formula tion, the toxic potential was greatly increased due to an increased opportunity to migrate from the plastics. M. M. Fetkovich 1707b Changes in resistance to acids of erythrocytes during poisoning by some industrial poisons. M. G. Polyak, P. A. Balander, V. N. Fcdyanina, and T. I. Nevolina (Nauch.-Issled. Sanit, Inst., Novosibirsk). Vop. Biofiz., Biokhim. Fatal. Eritrotsitov, Akad. Nauk SSSR, Sib. Old., Inst. Fiz. 1967, 173-9 (Russ). The effect of mesidine (I), dichloroisobutylcne (II), and dioxydiphcnylpropane (III) on erythrocytes was tested in 50 rats and 28 rabbits. After I inhalation of concns. of 1,8-4.7 mg./l., close to the LD, the no. of erythrocytes was not affected, but mcthemoglobin increased by 3-5%; this increase, neverthe less, was not correlated with the severity of poisoning. In rabbits chronically poisoned with 0.01 mg. 1/1., reduced gluta thione in the blood increased after 4 months, whereas lower doses of I were without effect on its level. Acid resistance of the erythrocytes showed a left shift after poisoning with 0.001 mg. I/l,; after 0.01 mg./l. shifts both to the left and to the right occurred. II caused injury to the liver and was more toxic than CCL: 3 mg./l. caused hemolysis in rats, their erythrocyte no. decreased from 8.3 to 5.8 X 10*/mm.* and Hb decreased from 14.8 to 9.0 g. %. At the same time, reticulocytes increased from 460 to 708 X 10J/mm.' Changes on erythrograms of rats chronically intoxicated with 0.6 mg. II/l. for 3-5 weeks were similar to the changes after acute poisoning, but the no. of erythrocytes, reticulocytes, and the conen. of Hb did not differ from intact animals. Ill had effects similar to phenol; erythro grams normalized within 25 days. Crystn. of native Hb oc curred in the erythrocytes of rats poisoned with II or III. M. Kalab 1708c Glucuronide formation in cases of toxic liver damage. K. Beck, H. A. Kuehn, and B. Nouraie (Med. Univ,, Freiburg/ Br., Ger.). Acta Hepato-Splenol. 14(5), 280-91(19G7)(Gcr). Rabbits were poisoned either with a single s.c. injection of 1.5 ml. CCL/kg. of body wt., 0.3 ml. CCli/kg. of body wt. each 3rd day 6 times, a total of 40 ml. CC1< over a long period of time, or with daily s.c. injections of 0.4 ml. 5% aq. allyl ale. (I) soln./ kg. body wt. for 23 days to test the liver capacity of elucuronide (II) synthesis. The rise of plasma Il-glucuronic acid (III) as well us the urinary excretion of III after loadin': with 1 4. .Y-accty'.- p-aminophenol showed that the max. blood levels were readied only after 3 hrs. (in normal animals after 1 hr.), while the total increase was also considerably lower than in normal animals with a concomitant delayed urinary excretion of III. The dis turbances of the II synthesis are not as marked in cases of sub acute poisoning, while in chronic poisoning (CCL cirrhosis) only a shift of the max. to the 2nd hr. was observed. Poisoning with I produced no significant influence on II synthesis. These results confirm findings in humans in which a disturbance of II formation (after loading with menthol) only occurs in cases with I ..`V* 74452 Chemical Abstracts Vol. 66, 3967 13L. hemagglutination reaction--extn, and purification of antigen-- 72443g. Immunochenj. studies of insol, wheat prut selection of inactivation method (Rezepova) 68873e. Some bano) 72465r, Fluorescence depolarization iiumvi, factors that influence the iodination of ox insulin (Glover) pyrene-butyric acid-bovine serum conjugates (Knu;,- 14--TOXICOLOGY i OLI 2578 '^A (p(* 7*/^ T. K. TORKELSON 744S2h A simple apparatus for the estimation of some gaseous or volatile toxins. H. L. Boiteau and Cl, Moussion (Fac, Med. Phartn., Nantes, France). Ann. Biol. Clin. (Paris) 25(1-2), 215-27(19G7)(Fr). The app. is made up of 2 compartments con nected through a glass stopper. The first one, of known voi. (approx. 100 ml.) contains the sample to be analyzed. The second one (approx, 10 ml.) contains the reagents used in the detn. By connecting the 2 containers, the reaction can proceed and the detn. carried out colorimetrically or volumetrically. With this app., CO, COt, N,CU, HCN, and trichloroethylene were detd. within the limits of the sensitivity of the specific detn. Rene Evard 74453j Poison chamber and a setup for creating constant vapor concentrations under dynamic conditions. N. Sh. Vol'bcrg and A. A. Golubev (Inst-- Ind. Hyg, Prof. Diseases, Leningrad). Gig. Tr. Prof. Zabol. 10(12), 49-50(1966)(Russ). A chamber is described which contains small flasks for individual mice. The flasks are supplied with glass capillaries to ensure const, flow of poison-contg. gas. This app. was suggested for poisoning mice with halosilaiies. To avoid halosilanes decompn. with moisture, air was dried in a column of silica gel and then on zeolite NaA (mol. sieve). Inlet of toxic fluid terminates on an elec, heated coil, where the fluid evaps. and enters the air stream. Miloslav Kalab 74454k Toxicity studies of latex rubber and soft poiy(vinyl chloride) as tubing materials. Comparison between in vitro tests and results of prolonged administration to rats. L. H. Eklund, C. A. Grant, and V. Willners (Kgl. Farm. Inst., Stockholm). Acta Pharm. Succica 2(5), 349-56(1965)(Eng). A comparison has been made between in vitro and in vivo proper ties of water exts. of latex and poly(vinyl chloride) products. Sixty rats were injected 1 ml./lOO g. of body wt. i.p. for 12 weeks. Hematological, liver and kidney tests, and pathol. examns. were carried out. At the end of the study, no appreci able differences from the control animals were observed. The value of in vitro tests as a relevant parameter of toxicity of polymer products is discussed. R.CTT 74455m Alterations in microsomal electron transport, oxida tive N-demethylation, and azo-dye cleavage in carbon tetra chloride and dimethylnitrosamine-induced Over injury. E. A. Smuckler, E. Arrhenius, and T. Hultin (Wcnner-Gren Inst. Exptl. Biol., Stockholm). Biochem. J. 103(1), 55-64(1967) (Eng). The effect of administration of CCU and dimethyl- nitrosamine in vivo on hepatic microsomal function related to drug metabolism was measured. The capacity of isolated micro- somes to demethylate dimethylaniline was diminished during the 1st hr. after CC1, poisoning and during the 2nd hr, after dimethyl- nitrosamine poisoning. Thereafter the microsomes from CCU- poisoned livers showed a continuous decline in activity so that at 24 hrs. there was little residual capacity to undertake demethyla- tion. Microsomes- from dimethylnitrosaroine-poisoned animals were not different from controls at 24 hrs. During the first 3 hrs. there was a transient rise in the accumulation of the N-oxide intermediate in CCU-poisoned livers, with a subsequent fall to below control values. In diraethylnitrosamine poisoning there was a parallel decrease in A'-oxide accumulation with decreased demethylation. In the latter part of the first 24 hrs., theratioof IV-oxide accumulation to demethylation was increased in both instances. At 2 hrs. after poisoning with either compd., there was no evidence of altered NADPH-dependent neotetrazolium redn. or lipid peroxidn. NADPH-dependent azo-dye cleavage was decreased. There was no difference in microsomal cyto chrome bs content, but there was a decrease in the amt. of cyto chrome P-450. This latter change was correlated with the decreased capacity for NADPH-dependent oxidative demcthyla- tion. It is suggested that dimethylnitrosamine is assoed. with a defect in microsomal NADPH-dependent electron transport at the level of cytochrome P-450. In addn. to affecting cytochrome P-450, CCU is asmed. with a 2nd severe block involving the release of formaldehyde from the A-u:.ide intermediate. RCFG 74456n The effect of the aflatoxins Bi, Gi. and G- on protein and nucleic acid synthesis in rat liver. Janet I. Clifford, K. R. Rees, and M. Elizabeth M, Stevens (Univ. Coll. Hosp. Med. School, London). Biochem. J. 103 , 25S--61 (1967){Eng). A comparison has been made of the difference spectra obtained by causing various aflatoxins (Bi, Gi, and G*) to interact with calf thymus DNA. The effect of these toxins on RNA and protein synthesis by rat liver slices has been measured. The extent of their inhibitory action on the synthetic reactions was proportional DNA. It is proposed that their toxicity depends .,t, action. It was demonstrated that the RNA p,.|. nucleoli isolated from the livers of aflatoxir. Bi-pnin,: inhibited. This finding is in agreement with G , mechanism for the hepatotoxic action of aflatoxin. 74457p Effect of pretreatment with polycyclic hvr'.r on the metabolism of dimethylbenzaiuhraccne- U-:,C 1, and other tissues. P. H. Jellinck and Barbara British Columbia, Vancouver, Can.). Biochew, < 15(1), 131-41(1967)(Eng). Pretreatment of rats it polycylic hydrocarbons (3-methylcholanthrene. hi anthracene, benzo(c)pyrene, anthracene, phenanth: naphthalene) alters the metabolism of 7,12-dinv. anthracene (DMBA) by hepatic tissue from sidc-c:-.. hydroxylation. No change in the metabolism of DM): adrenal glands was observed under these conditions, . hydroxylated metabolite of the carcinogen was form, tissue. It is suggested that protection by aromatic liy.:- against DMBA-induced adrenal necrosis is achieved by,. the yield of the 7-hydroxymethyl deriv. of DMBA in This product, rather than the unchanged carcinogen, m the proximal necrotic agent by virtue of its structural rt- to the adrenocortical steroids. The cytotoxic effect adrenals may be due to damage of cellular membr release of lysosomal enzymes. 24 references. I. 74458q Metabolism of chloroethanol in the rat. Johnson (Med. Res. Council Labs., Carshalton, Eiu.I, chem. Pharmacol. 16(1), 185-99(1967)(Eng). When ethanol is given orally to rats, liver GSH (reduced glm is rapidly depleted and 5-(carboxymethy])glutatliiont t Release of "Cl- from chloroethanol-54Cl has been studa,. and shown to require stoichiometric amts, of GSH il ;. NAD (2 moles), 5-(Carboxymethyl)glutatluone li - identified as the product in vitro. Ethanol inhibits the of GSH in vivo and release of "Cl- in vitro. Chloroei. readily dehydrogenated in vitro by purified yeast and 1; ale. dehydrogenases. The route from chloroethanol t boxymethyl)glutathione has been studied in vitro. 5- x methyl)glutathione is degraded by kidney homogenate u glutamic acid, and S-(carboxymethyl)cysteine. hm metabolism of the latter compd. is discussed. It is that the toxicity of chloroethanol is due to its coitv; chloroacetaldehyde in vivo. A 74459r The effect of carbon tetrachloride on rat lb somes. David H. Alpers and Kurt J. Isselbacher * Med. School, Boston, Mass.). Biochim. Btcphys. .1:.'; 33-12(1967 )(Eng). The effects of CCU on isolated A and rat liver slices were examd. The addn. of CCU to lysosomes caused the release of F-glucuronidase, acid ! tase, and acid RNase activity. The release occurred lag period and was linear. In addn., the rate of n > dependent on the CCU conen. CCU added to liver slice a redistribution of the lysosomal enzyme activity su>: greater percent was found in the supernatant vs, the p e fraction. Under these conditions leucine-"C incorpor.c protein was inhibited. The effects on lysosomal enzyjm leucine incorporation were roughly comparable for a gi'1' of CCU. Studies of the kinetics of these changes rev i to be linear and to occur without any detectable L- Lysosomes were isolated by 2 different methods, such peroxidn. occurred to a much greater extent tn one pn-: pared with the other. Despite this difference, CCU ; comparable release of lysosomal enzyme activity in but Furthermore, in neither lysosomal fraction did CCU lipid peroxidn. at a time when its effect on enzyme acti max. 32 references. 1J 74460j Veterinary toxicology, to make a diagnosis. Buck and Virginia Marshall (Iowa State Univ., At"1' Slate Univ. Vet. 28(1), T-OdOGOVEng). Nv/'-er chem. toxicants and their diagnosis in veterinary u ; discussed. Martin r 74461k Histochemical enzyme levels in experinu cirrhosis. T. Tashev, L. Krustev, and L. Bal ib.m Inst. Khranene, Bulgar. Akad. .\auk 5, 20-3X11!" Exptl. liver cirrhosis was induced in rats by daily sill".- injection of CCU (0.05 ml.) during 3 months. Aik. P1'"' was neg. in normal liver parenchyma and bile duct-. ^ strongly pos. in hepatic cells of cirrhotic areas, L" changes were observed with acid phosphatase, its act'- 1 .. ...i l..u _r*u; ....... I- .1, i I clrrt'o-.' I Abstracts Vol. 66, 1967 p,* "88 ^Pbictz Tiomology ili Titani, v., Bloomlic amino _d. There hains, but . homology ,1 relations frentiation RCMH Section 12. yribosomes )2St. Difr) 61944V, if pituitary ificance in t) 622 lOq. Immunofluorescent localization of calcitonin in C cells of pig and dog thyroid (Bussolati) 63179y. Differentiation and functional expression of potential antibody-producing cells in presence of chloramphenicol (Schoenberg) 640l0y. Action of heparin and aminoguanidine on anaphylactic, anaphylatoxin- and histamineinduced shock in guinea pigs (Giertz) 64178j, Effect of anti coagulants on delayed hypersensitivity reactions (Cohen) 64146i, Side effects of drugs on granulopoiesis and throinbopoiesis (Hoppe) 63912g. Inhibition of chlorophyllin derivs. against complement activities and anaphylactic reaction (Sindo) 64140r, Effect of ,\'a Cu chlorophyllin as complement inhibitor on allo graft reaction (Fujii) 64141s, Effect of Imuran (azathioprine) on susceptibility of guinea pigs to allergic encephalomyelitis (Field) 64Q64U. Elucidation of structure of Vi-antigen isolated from (Escherichia coli) 5396/38 (Heyns) 65785s, Effect of chloroprene on immunologic reactivity of organism in persons vaccinated against typhoid fever (Mikaelyan) 58658z. Analysis of the crystal antigens of Bacillus thuringiensis by gel diffusion (Pendleton) 62794h. Interferon and interferon-like substances-- present state of research (Lackovic) 62728q. Patent: Allergen prepns. (Aktiebolag Cernelle) 58845h. 14--TOXICOLOGY 7s R. TOREBLSON idology to ompounds; Marseille. Commun., A review properties A. Colas tag water, ind). Caz, h~ present 1 for babies, of bacteria Nitrates hange on , or CCV Kloczko ^stations of substances. . Eizengart Tr. Prof. 'tat original ethylamine, rcaptan on nature and terior hypo: extent of 'O reported. av Kalab 1. Swamina. J. Nutr. A review d the signs ic principles Vicia were The chief and other i is available the carboxy derivs. have of lathyrism leaching in Cameron William B. iiv., Ames), ignosis and mts are dis Jacobson urns (Texas Vet. 18(4), e, poisonous cidcs, fungi- Numcrous J acobson ; i J composiiged alcohol ng, and L. hem. Scand. 1-ong-term mbolistn and litochondrial 1 metabolism it nonsignifi1 a slight in crease in that of neutral lipids were observed in mitochondria from alc.-fed rats, compared with controls. The compn. of the phospholipid fraction was nearly identical in the 2 groups of animals. 22 references. BXJN 63S66v Diuretic therapy of acute intoxication with hypnotics. G. A. Krueger (Evangelischen Krankenhauses, Muelheim, Ger.). Anaesthetist 16(2), 40-4(1967)(Ger). Furosemide (20 mg-), injected i.v, into patients with barbiturate intoxication and added to running infusions dependent on the progress of the case (an av. of 20 mg./lOOO ml.), was an effective therapeutic measure against the intoxication. The drug was easily ad ministered and could be safely used in case of diabetes or com plications caused by depression of cardiac, circulatory, or liver functions. It considerably reduced the time of unconsciousness and hospital treatment. Circulatory analeptics, particularly ethyldiphenylpropenamine, were effectively used in cases of hypotension in order to reestablish normal blood pressure values. 46 references. _ BKJG 63867w Electroencepbalographic changes in chronic poisoning with trichloroethylene. K. Schwartzova (Karlova Univ., Plzen, Czech.). Cesk. Neurol, 29(6), 369-77(19G6)(Czech). Examns. of 78 persons, exposed for 7.5 years on the av., re vealed insufficient mental relaxation, lowered vigility, and dis turbance of the a rhythm (on the border of abnormality) in 46.1%, small focal lesions and few synchronous 8 waves (slight abnormality) in 5.1%, and frequent disperse or diffuse 8 waves with synchronous exacerbations or focally accentuated (moderate abnormality) in 34.5%, of the cases. L. J. Urbanek 63868X Depression of potential myocardial contractility accompanying chronic ethyl alcohol administration. Joha Elwood Maines, III (Tulane Univ., New Orleans, La.). Univ. Microfilms (Ann Arbor, Mich.), Order No. 66-10,767, 88 pp.; Diss. Abstr. B 27(5), 1561-2(1966)(Eng). SN'DC 63869y Subacute toxicity of ether extracts of PVC. S. Homrowski, H. Piekacz, and H. Mazur (Staatliches Inst. Hyg., Warsaw). Ernaehrungsforschung 11(3), 398-402(1966) (Ger). Toxicity assessments of H30--free Et-O-extd. plates of a polyfvinyl chloride) (PVC) plastic (consisting of PVC 89.5, Pala- tinol AH (dioctyl phthalate) as plasticizer 7, Advastab 17-W (S-contg. org. dibutyl Sn compd.) as stabilizer 1.0, Advawax 360 as lubricant 0.5, and TiOi as pigment 2.0%) were carried out by thin-layer chromatography of blood specimens obtained periodically from Wistar rats of both sexes with starting wts. of 100-125 g. In addn. to a standard diet, by means of a stomach tube, 60 animals received 1 or 100 mg. PVC ext./kg. body wt./ day as a 0.3 or 30.0% suspension, resp,, in olive oil, for 3 months, and 10 of these animals received 1 g. undild. PVC ext./kg. body wt./day throughout the 4th month. All exptl. animals exhibited normal behavior, appearance, and eating habits; body wt. gains and blood-constituent values were similar to those of olive oil- treated control animals. No significant macro- or microscopic lesions of liver, spleen, kidneys, or stomach were revealed follow ing removal after sacrifice of animals by Et-0 narcosis, with the exception of a statistically significant liver enlargement (about 28% heavier than for controls) among animals receiving 1-K- doses of ext. Only about 25% of the total content of non-P\ 0; contg. plastic constituents was extd. by the Et*0, of which 96% was plasticizer and 3% stabilizer; it was assumed that the other 7% consisted of the lubricant, since the pigment is practically insol. in EtjO. On the basis of reports, the plasticizer and lubri cant, both with an LD range of 33-35 g./kg. body wt., were practically nonpoisonous, whereas the LDso value for the stabil izer was 500-600 mg./kg. body wt., indicating that any toxicity r / O'i pio C'J H o Page 59B9 ^)3 ^--Toxicology evident in plastics exts. was due to the stabilizer. Doses of 100 I and 1000 mg. PVC ext./kg. body wt., which corresponded to \- about 3 and 30 mg. stabilizer/kg. body wt., resp., did not elicit any adverse reactions; the heavier wt. of the liver, as a result of p hemorrhage of its blood vessels, was considered to be evidence of 1 an enhanced activity of this organ in handling the increased amt. \ of ext. content. Roy Solkot 11 63870s Hepatotropie action of N-methylformamide. V. N. Vasil'eva and T. M. Sukharevskaya (Inst. Ind. Hyg.- Ppof. i Diseases, Moscow). Gig. Tr. Prot. Zabol. 10(12), 53-4(lf)GC) g (Russ). A case history is presented of a person who drank 50 : ml. of JV-methylformamide; even after washing the stomach with - water, acute injury to the liver developed, accompanied by v proconvertin (1) decrease (by 24%) in the biood and increase of i. plasma fibrinogen to 910 mg. % I normalized more slowly than t any other biochem. index. Miloslav Kalab f 6387 It Toxicity of phthalodmitnle and tetrachlorophthalodi- t nitrile. I. Acute toxicity in mice. Hiroshi Yoshikawa and I. Kiyoyuki Kawai (Nat. Inst. Ind. Health, Kawasaki). Ind. r Health (Kawasaki, Japan) 4(1-2), ll-15(1966)(Eng). Five to ii 30 min. after intraperitoneal, subcutaneous, or oral administra- v tion of e-phthalodinitrile (1), mice had generalized convulsions I lasting 10-15 sec. The convulsive attacks were repeated several s times with 30-60 sec. intervals and death occurred within 5 hrs. 1. Upon administration of the meta isomer of I, convulsions were less marked and animals receiving the para isomer showed only weak- n ness. The resp. LD values of o-,m-, and j>-I were 3-1.5,481.3 and C G98.6 mg./kg. LD values for 0-, m-, and #>-tetrachlorophthaIo- t dinitrile administered intraperitoneally were 66.4, 2.5, and 1581 t. wg./lcg. Convulsions were absent with the chlorinated derivs. r, Emanuel Kaplan t 63872u Hepatotoxicity of a series of organotta esters. David J. Galley, W, L. Guess, and J. Autian (Univ. of Texas, Austin), r J. Pharm. Sci. 56(2), 240-3(1967)(Eng). Four organotta esters r. having use or potential use in the formulation of medically used plastics were evaluated for their toxic effects on the liver follow- ing oral administration. The liver damage is apparently the c cumulative type, requiring several days to manifest damage in the form of elevated serum glutamic-pyruvic transaminase values and prolonged hexobarbital narcosis. The toxic potential was, in c general, soly. related. RCYG 63S73y.l Effect of Vandid on cardiac functions in experimental trichloroethylene poisoning. A. Kubacki, A. Mrozikiewicz, [ A. Skubiszynska, and A. Wachowiak (Akad. Med., Poznan, Poland). Med. Pracy 17(3), 196~200(1966)(PoI). Electro- : cardiograph curves were surveyed in rabbits exptl. poisoned with h trichloroethylene. Administration of Vandid (Y.A'-diethyl- u vanillamide) (5 mg./kg.) produced no arrhythmia symptoms, which occurred, however, when adrenaline (0.1 mg./kg.) was r. used as the cardiac stimulant. Helena Lange ti 63874w Histochemical evaluation of liver extracts in prophy- '. laxis of experimental carbon tetrachloride poisoning. Kazimierz i* Zajusz and Marek Zacharewicz (Inst. Med. Pracy, Zabrze, Poland). Med. Pracy 17(4), 317-28(1966)(Pol). CC1, ad- ministered by stomach tube to rats (0.6 mi./animal) caused an r initial increase of the liver acid and alk. phosphatases and ATPase ; activities, but this trend soon discontinued and the enzymes < became inhibited almost completely. Liver succinic dehydro- i genase, phosphorylase, and the branching enzyme were also c totally inhibited. Enhanced reactions for alk. and acid phos phatases were observed in the kidneys of the poisoned animals. : The effects of CC1, were markedly moderated by prophylactic administration of hepatic exts. Helena Lange , 63875x Pathomorphologic changes in white rat organs during chronic combined inhalation of methanol, aqueous ethanol, and furfural. R. U. Ubaidullaev and P. V. Panov. Med. Zk. Web. : 1966(9), 70-3(Russ). Three different conens, of a mixt. of i vapors of MeOH, aq. EtOH, and furfural were used in an in halation expt. of 3-months duration. Severe histol. changes j were found at the highest concn. only (5.79 mg. MeOH/m.'- 1 28.48 mg. EtOH/m.M),3 mg, furfural/ra.*). RNA of brain and glycogen of liver decreased, accompanied by fatty liver distrophy. J. Prukes 63$76y Morphological changes in the organs of animals in acute and chronic intoxications with a-methylstyTene and styrene. V. Veselova and G. A. Ogleznev. Nauch. Tr. Omsk. Med. < Inst. No. 61, 89-95(1965)(Russ). Expts. were conducted on mice and rats administered intragastrically an aq. soin. of a-meth- ylstyrene (X) or styrene (II). Internal administration of max. tolerance doses of I (3 for mice and 4 g./kg. for rats) and II ho and 2 g./kg., resp.) caused no marked morpholocica! cnaiigr acute I intoxications, grave hemodynamic and d> -tre*; enanges in the parenchymatous organs, most pronounced in the lungs, were recorded. The group of morphol. changes found m the central nervous system of animals with I intoxication was a 'Indrome of toxic encephalopathy. Morphol. changes yaux'ta y I intoxication did not essentially differ from II-causcdxhungcs. _ t-hronic administration of II (0.014 mg./kg.) to rats caused* oe- Velopment of dystrophic changes in the central nervous system more often than did 0.5 mg. I/kg. under the same conditions. I lien/ Abstracts Vol. 66, 1967 Page 118 ^9J9l/^Sh)c, d3CtlWin1t ith clilororotcin con- in. by an un it- influence of s ui-re inconj fictor in this -itv. were con,S with chloro- t* activities of vnivic transaiul Frankel btt'vpki units, n bJmKl, liver, . animals. In normal tissues , the spleen the a- enzymic acilnriiprene rea higher level y of pyridoxal l" that the iniy its reaction .. Bedighian cholesterol in id and hepatoWerke-Krank0810), 748-50 vels of clioleslinistration of atioti of cthiolaii/rd follow* ig./kg.) given CMJG i (rat) toxicity ate). D. E. tish Ind. Biol. Toxicol. 4(4), s studies have hli<ethyltne gly* ,D.m in both when given effect. The DDGB was i 90-day study 1.0, and 2.5% i both sexes at t was attributugh this effect hematological ind 2.5% diets and the relaicreascd. No cd to DDGB. ictary level of lays could not ested. RCTT ols. Norman Merck Chem. >n. Chem. Soc. i reacts with nrm relatively lv reported ine explained in impiexing and RCJC ating agents. vtrm. Pharma cy of effectiveie mustard, bI produced a red intracerelty included a gns of central ype behavior, d tonic extenphamide, and 'cd in doses of henvtniii (100 1 " < ITe, w ip. > i" ne " un.. '1 ?./ Milling the C.MJN iment on the L). B. Meyers, Greenfield, 66)(Eng). A method using rats that can be of value in predicting tile effects of chronic treatment with psychotherapeutics on the acute toxic ity of other medicinal agents is described. Results obtained by this method showed that nortriptyline, like amitriptyline, en hanced the toxicity of most ccrebial depressants in an additive manner. Both of the nutidepressive coinpds. markedly potenti- ' ated the toxicity of pliysostigmine and to a lesser degree pilocar pine. Eplicdrine toxicity was significantly antagonized by thymolcptie pretreatment. The test faile'd to verify reports that the tricyclic antideprt-ssives dangerously potentiate tlje toxicity of ale. or monoamine oxidase inhibitors. Results indicated that a variety of medicinal agents can be used in the nortriptyline treated patient without any problem of significant drug inter action. RCYG 1236r Chlorinated anilines and their sanitary-toxicological characteristics. G. D. Khainuev. Khim. Faklory Vneskn. Sredy i ikh Gigicn. Znachenie, 5b., Moscow 1965, 108-10(Russ). Monochloroaniline is used in the production of insecticides and dyes. wi-Monochloroanilinc (I) and ^-monochloroaniline (II) dis solve in HjO (5 g./l.), in which they cause an unpleasant taste and odor. The odor and taste perception thresholds were 2.6 and 7.2 for I and 1,5 and 3-6 mg./l. for II, resp. In a conen. of 150 mg./l., I and II lowered the B.O.D. of water. Threshold conens. are 1.5 mg./l. for I and 0.75 mg./l. for II. The L.D.so values (stomach administration) for I and II, resp., were 1104 and 401 for white mice, 1104 and 368 for white rats, and 750 and 350 mg./kg. for guinea pigs. A 3-month sub-acute expt., conducted on white rats with stomach administration of 0.1 L.D.so levels, caused the formation of methemoglobiii and re duced the hemoglobin level and the erythrocyte count. From Ref.Zh., Khim. 1966(8), Ft. II, Abstr. No. 81414. MVRK 1237y Toxicity of thioacetamide. Z. Hruban, W. Gradman, A. Slescrs, and M. Lubran (Univ. of Chicago). Lab. Invest. 15 (11), 1748-60(1966)(Eng). Thioacetamide (I), fed to rats in a diet contg. 50 mg./kg. body wt./day for 5 days, produced high serum lactic dehydrogenase levels and centroiobular necrosis of the livers within 24 hrs.; the enzyme levels decreased and the necrotic areas were resorbed within 3 days of feeding the diet. Severe degenerative changes in the kidneys, hematuria, and in creased serum urea N and serum creatinine levels occurred within 48 hrs. of treatment. The lethal effects of the above level of I were correlated with the renal damage. Excess dietary casein hydrolyzate, methionine, or guanosine reduced the mortality , and renal toxicity of I, although these compds. did not prevent the nuclear and nucleolar enlargement of hepatic cells and of the cells of the proximal convoluted tubules of the kidney occurring in treated rats. 67 references. BPJN 1238f Poisoning by grass. C. H. Gallagher, J, H. Koch, and H. Hoffmann (Univ. Sydney). New Scientist 31(510), 412- 14(1966)(Eng). Acute and chronic neuromuscular disorders occur in sheep feeding on the pasture grass Phalaris luberosa. This grass contained 0.3% (dry wt.) tryptamine alkaloids. Tissues from sheep undergoing acute poisoning showed no histol. alterations, whereas the brain and kidneys of chronically poisoned animals showed deposits of green pigment. The pigment was noted in the mitochondria cells of the mid-brain, brain stem, and spinal cord. It is suggested that these changes are related to the oxidative deamination of A'.A'-dimethyltryptamine and 5-me- thoxy-jV.A-dimethyltryptamine. The protective action of Co * against the chronic form of the disease, reported by others, may , be related to the prevention of degenerative changes in nerve i tissue or to the acceleration of alkaloid metabolism. I W, L. Downs y { 1239p Vinyl chloride; industrial toxicologic aspects. I. p* i Grigorescu and Gh, Toba. Rev. Chim. (Bucharest) 17(8), 499- i 501(1966)(Rom), A hypothesis was put forward, claiming that j CHiiCHCl (I) could react with HjO at the level of the hepatic cell, yielding ethylene monochlorohydrin, which could be oxi- ; dized to chloral and chloroacetic acid (II). II could be elimi- \ nated as such in the urine or be metabolized further through ami- j nation to glycocol. An anal, method was developed for detec- j tion of XX in urine, assuming that the only other source of II j could be massive ingestion of wine yeast or inhalation of trichloro ethylene. An aliquot (200 cc.) of urine, acidified with 50% J HsSOt (2 cc.) is extd. with Et;0 (200 cc.), shaking vigorously, and settling for 24 hrs. The ext. is dried (anhyd. NajSO*), j evapd. to dryness under reduced pressure, and the residue is dis- solved in 50% aq. ale. soln. (0.5 cc.). One drop of the soln. j (25-30 /il.) is placed on Whatman No. 1 paper strips (25 X 3 cm,), dried, and chromatographed by ascending method, i using as eiutant the mixt. NRiOH-EtOH-H-O (1:20:4) for a period of 0 hrs. The strips, dried in air, are kept 24 hrs. in a oiled. XHj atm., heated lor 5 min. at >')', sprayed wuh H.1% ninhydrin in MeOH, and dried. The II is indicated by reddish- violet spots. For distinct development, the strips arc sprayed finally with 10% Cu(NOj)i (carmine red spots). The Rf at 24 was established with a soln. of 20-30 ms- Il/cde, at 0.S9. The limit of sensitivity is 0.1 ug. II, and is improved by the use pf Cu- (XOj)i. The extn. of II from urine was demonstrated by treat ing a soln. of 25 uS- II/cc. in urine as above, cutting the corre- f fae ns ^ y 14--Toxicology spending spots, eluting the II with EtOH, and detg, colorimctri- caliy. The extn. yield was --80%. Preliminary tests shim a! no II in clin. healthy personnel, while among the staff of I-proe- cssing plants, 80% of the sampled persons gave a pos. reaction to tile method. Extensive tests showed that most of the pos. reactions were obtained with staff employed 2-5 years in the plants. In these cases the protcinograms were modified, the a- globulin fraction being higher and the y-globulin fraction being lower than in the persons with ncg. reactions to the pres ence of II in the urine. It was concluded that the capacity of the organism to metabolize II decreased after 2 years. M. Ben Eiiescr 1240g Effect of hexachloro-p-xylene ingestion on the oxidative phosphorylation of rat liver mitochondria. Hsia-Ying Chang and Chen-To Yuan (Sino-Soviet Friendship Hosp,, Peking, China). Sheng W'u Hua Hsueh Yu Sheng Wu lYu Li Hsueh Pan 6(3), 273-5(1966)(Ch). Oral administration of hcxachlom-p- xylene (I, 0.5 g./kg./day) to rats uncoupled the oxidative phos phorylation of the liver mitochondria, in extent proportional to the duration of I treatment. The decrease in the production of ATP with insufficient energy supply of tissue may be the basis of the toxic reactions of I such as generalized weakness, fatigue, dizziness, headache. BHJJ 1241q Adrenaline-inactivation capacity of the normal and of the CCL-poisoned liver perfused in vitro. Emrna Costincr, L. Vaislcr, and Viorica Chivu (Acad. Rep. Soc., Romania, Bu charest). Studii Ccrcctari Endocrinol. 17(4), 355-7(I960)(Rom I, Normal rat livers, and livers originating from CCL-treated rats were perfused with adrenaline in vitro. The latter showed a lower rate of adrenaline degradation as compared with the former. BTJQ I242x Pyruvic acid content in acute barbiturate poisoning. B. F. Murashov (S, M. Kirov Mil. Med. Acad., Leningrad). Ter. Arkh. 38(10), 103--l(19G6)(Russ). In deep coma due to barbiturate intoxication, 1.2 mg. % pyruvic acid (I) was found in the blood. Its concn. decreased with recovery to 0.77 mg. %. When the I concn. reached 1.8-2 mg. %, complications occurred and the respiration was disturbed. The I concn. was directly proportional to the severity of intoxication, as observed in a total of 32 poisoned humans. Miloslav Kalab 1243e Inhibition of biosynthesis of protein and nucleic acids by phenolic compounds in vivo. G. V. Kukushkina, L. B. Gor bacheva, and N. M. Emanuel (Inst. Chem. Phys., Moscow). Vopr. Med. Khim. 12(5), 452-5(19G6)(Russ). Mice with the Ehrlich ascites carcinoma or solid hepatoma XXII were injected with a mixt. of uniformly >'C-labeled L-amino acids (I) (10 jic./ mouse), Na formate-1*C (II) (5 uc.) or adenine-S-1*C (III) (17 nc.). After 30 min., one group was injected intraperitoncally with Pr gallate (IV) in 0.9% NaCl and another, with 4-methyl- 2,6-di-fcri-butylphenol (V) in 3% aq. Tween-80. Controls were injected with the resp. solvents. Ascitic fluid samples were taken from mice with Ehrlich tumors at time intervals from 0 to 180 min. and the cells washed with a 5:4:1 mixt. of 0.9% NaCl, 0.3M NajHPO.1, and 0.3A/ KHsPOt. Mice with solid tumors were sacrificed after 120 min. and the tumors, liver, kidneys, and spleen were removed and homogenized. When I was used, the cells were treated with cold 5% CLCCOOH and the pptd. pro teins isolated and examd. When II and III were used, 5% Clj- CCOOH washings were extd. with EtjO, the aq. layer evapd., and the residue (acid-sol. fraction) examd. for radioactivity. The acid-insol. fraction was washed with cold 96% EtOH and heated for 10 min. at 50 with EtOH-EtjO (2:1) to remove lipids. A sample was examd. for radioactivity and the rest extd. with 10% NaCl (pH 7.4-7.6) for 30 min. at 95. Nucleic acids were pptd. by adding 3 vols. of cold 96% EtOH and washed with "0% EtOH. In mice with ascites tumors, injection of 75 mg./ kg. of V decreased I incorporation into protein by 30% as com pared with the controls; 200 mg./kg. of V inhibited I incoi posi tion almost completely. Injection of 100 mg. of V/kg. de creased III incorporation into nucleic acids by 20%; 200 mg. of V/kg, inhibited III incorporation almost completely. Injec tion of 80 mg. of IV/kg. or of 120 mg. of V/kg. after 150 nun. de creased II incorporation into acid-insol, fraction by 43-5"/',, into nucleic acid by 54-61%, into acid-sol. fraction by 50-77%, and into proteins, by 30--14%. In mice with solid hepatoma, in jection of 150 mg. of IV/kg. after 150 min. decreased I incorpora tion into tumor proteins by 26%; 200 mg. of IV/kg. decreased I incorporation by 63%. Injection of 150-200 mg./kg. ol IV had no effect on protein biosynthesis in kidneys and the liver of normal mice and in kidneys of tumor-bearing mice which showed some activation of I incorporation in the liver. Injection of -nl> hi-- of IV/kg. decreased I incorporation into spleen prod h - "urinal and tumor-bearing mice by 30%; 150 mg./kg. had un 1 fleet on protein biosynthesis in the spleen. Felix liorik I244n Experimental intoxication by ammonium salts. Pro tection by some amino acids and their mechanism of action. 1-. U'imino and F. Salvatore (Univ. Naples). Biochim. .1 ppL 13 12), 57-85(1966)(ltal). The biochern. conversion of N'ilj into "rea is discussed relative to the protection afforded in acute ami chronic XH, intoxication by some compds. assoed. with the con- OLI 2580 A Guide to the Literature and Patents Concerning Polyvinyl Chloride Technology SECOND EDITION Edited by Lloyd R. Whittington Compiled by the Bibliography Committee of the Vinyl Professional Activities Group, Society of Plastics Engineers, Inc. Published by the Society of Plastics Engineers, Inc. for the 1363 Vinyl Professional Activities Group OLI 2581 C5 FILMS. W. E. ODERN PLASTICS 36, 59) LYMERS TO 90% J. Dletrlck and 3LYMER SCI. 2, No. >er 1959) 1Y UNSUPPORTED iugh, C. N. J, APPLIED bl (September/ ATER IN CONTACT . V. Woelk. 775 (December IS TO OASES. B. 3GYO KAGAKU ANIC POLYMERS TO Berlin and k, p. P. 2252 UGH POLYMERIC 'nraltt and R, M. 3 SCI. 3. No. 7, 3) FILMS FOR GASES OF THE DEGREE OF S'JTION ON THE BUNSHI KAGAKU .POLYMERS. H. H. 7 POLYMER SCI. ;5o) ZED PVC. H. OD. 12, No. 7, ZED PVC. H. 275. p. 359 ASTIC FILMS, inuary 1961) IRMEABILITY C S. VI. THE W. Myere et anuary, 1961) ZERS ON THE HROUQH high YO KAGAKU jary, 1961) ITIES OF on and W. A. >) 26, No. 280, p. 117 (February, 1961) ON THE WATER VAPOR ABSORPTION OF CERTAIN POWDERED FOODSTUFFS AND THEIR MOISTUREPROOFING BY SOME IACKAGING FILMS. T. MOkino et al. KOGYO KAGAKU ZASSHI 6b, No. 7, p. 1255 (July 1961) THE PERMEABILITY OF PVC-CELLULOSE LAMINATES TOWARDS HYDROGEN SULFIDE AND AMMONIA. H. Braunish and H. Lenhart. KOLLOID-ZEITS 177, No. 1, p. 24 (July 1961) PERMEABILITY OF PLASTICS. I. Phillips and D. V, Bartlett. BRITISH PLASTICS 3b, No. 10, P. 533 (October, 1961) DIFFUSION OF GASES AND VAPORS THROUGH POLY VINYL CHLORIDE- POLYVINYL ACETATE COPOLYMER FILMS. I. GLASS TRANSITION EFFECT. II. THE EFFECT OF POLYMER SEGMENT MOBILITY. C. A. Kumlns and J. Roteman. J. POLYMER SCI, 55, No. 162, p. 683 (December 1961) WVT THROUGH MULTIPLE BARRIERS. K. W. Ninnemann and L. E. Slmerl. MODERN PACKAGING 2jj, No. 4, p. 137 (December 1961) PERMEABILITY OF PLASTIC MATERIALS TO WATER VAPOR. Marie Korte-FalInski. J. CHIM. PHYS. p9, No, 1, p. 27 (January 1962) DIFFUSION OF GASES AND VAPORS THROUGH UNPIGMENTED VINYL FILMS -- GLASS TRANSITION EFFECT, C. A, Kumlns 4 D. J. Waythomas. OFF. DIG. J. PAINT TECH. 4 ENG. b, No. 445, p. 117 (February 1962) ELECTRON permeability of high polymers, j. Sucka. PLAGTE u.' KAUT. 9, No. 3, p. 117 (March 1962) ACTION OF LOW-MOLECULAR LIQUIDS OH CERTAIN POLYMERIC MATERIALS. (effects of immersion In water and gasoline) V. A. .Voskresenskll. ZHUR, PRIKLAD KiilM. 35, No. 3,* p. 696 (1962); and J. APPL. CHEM, U.S.S.R. 35, No. 3, p. 676 DETERMINATION OF THE PERMEABILITY OF PLASTIC CONTAINERS TO OXYGEN. A.-Dousa and V. Slmak. OBALY 8, No. 4, p. 104 (1962) GAS PERMEABILITY OF PLASTICS. Coleman J. Major and Karl Kammermeyer, MODERN PLASTICS 39, No. 11, p. 135 (July 1962) HYGROFHOTOGRAFHIC STUDIES ON THE PERMEABILITY TO WATER AND MOISTURE OF PACKAGING MATERIALS. J. Slvadjlan and F. Corral. J. APPL. POLYMER SCI. 6, No. 23, p. 561 (September 1962) ISOSTATIC-CHEMICAL ANALYSIS METHOD TESTS FILM'S GAS PERMEABILITY. R. G. Marlett. PACKAGE ENG. 7, No. 10, p. 60 (October 1962) WATER VAPOR TRANSMISSION THROUGH POROUS FIIMS, D. Satas and D. G. Carr. J. APPLIED POLYMER SCI. 6, No. 24, p. s-64 (November/December 1962) GAS CHROMATOGRAPH MEASURES FILM PERMEABILITY. H. L. Frlcke. PACKAGE ENG, 7, No. 12, p. 51 (December, 1962) ~ 47. TOXICITY See topic 38, Packaging, for general references dealing with toxicity problems. SKIN TROUBLES FROM TEXTILES. W. Schwelahelmer. TEXTILE COLORIST 66, p, 69 (Feb. 1944) ACUTE AND SUBACUTE TOXICITY OF DI (2-ETHYLHEXYL) PHTHALATE -- ITS METABOLISM. C. B. Shaffer et al. J. INDUS. HYG. 4 TOX, 27, NO. 5, (May 1945) HEALTH HAZARDS FOR PVC AND ACRYLICS? PLAS TICS 12, No. 129, p. 85 (February 1948) TOXICITY OF O-TRICRESYL PHOSPHATE. 0. Blomqvlat. SVENSKA PLAST, FOR TEK. MED. 5, No. 1 (1950) THE TOXICITY OF TRICRESYL PHOSPHATE. N. Nelaon. MED. BULL. NEW JERSEY 10, p. 114 (April 1950) STUDIES ON THE TOXICITY AND SKIN EFFECTS OF COMPOUNDS USED IN THE RUBBER AND PLASTICS INDUSTRIES. II. PLASTICIZERS. F. S. Mallette 4 E. Von Haam. ARCH. INDUS. HYG. 4 OCCUP. MED. 6, No. 3, p. 231 (September, 1952) TOXICITIES OF BUTYL STEARATE, DIBUTYL SEBACATE, DIBUTYL PHTHALATE, AND NETHOXYETHYL OLEATE. C. C, Smith. ARCH. INDUST. HYG. 4 OCCUP. MED. , p. 310 (April, 1953) TOXICITY OF 2-ETHYLHEXYL DIPHENYL PHOSPHATE. I. IMMEDIATE TOXICITY AND EFFECTS OF LONG TERM FEEDING EXPERIMENTS, J. F. Treon, F. R. Deutra 4 P. F. Cleveland. ARCH. IND. HYG. OCCUPATIONAL MED. 8, p. 170 (August, 1953) TOXICITY OF 2-ETHYLHEXYL DIPHENYL PHOSPHATE. III. STUDIES OF THE EXTRACTION OF SANTICIZER 141 FROM POLYVINYL CHLORIDE FILMS 3Y FOOD STUFFS UNDER VARIOUS CONDITIONS OF STORAGE. J. Clark Kaskie. ARCH. IND. HYG. OCCUPATION AL MED. 8, p, 281 (1953) OCCUPATIONAL DISEASE IN THE MANUFACTURE OF POLYVINYL CHLORIDE PRODUCTS, (when contain ing chlorinated naphthalene) J. Roubal 4 F. Pokorny. frACOVNI LEKARSTVI 5, p. 144 (1953) TOXICOLOGY OF PLASTICS AND RUBBER -- PLASTOMERS AND MONOMERS. Rex H. Wilson & Wm. . McCormick, IND. MED. 4 SURGERY 2, p. 479 (November, 1954) FURTHER STUDIES OF POLYMERS AS CARCINOGENIC AGENTS IN ANIMALS, B. S. Oppenhelmer et al. CANCER RESEARCH 15, p. 333 (1955) SOME ASPECTS OF THE TOXICOLOGY OF PLASTICS. R. Forquet. MATERIE PLASTICHE 22, No. 2, p. 100 (February 1956) CHRONIC ORAL TOXICITY OF 2-ETIfYt HEXYL OLI 2582 523 / ,** / `I i; * ;tt ; 'ii I : * I * * 48. VISCOSITY , FLOW PROPERTIES PKTHAUTE in BATS AJ;d DOGS. R. S. Harris, H. C. Hodge, E. A, Maynard, 6: H. J. Blanchct, Jr. ARCH. IND. HEALTH 1_3, p. 259 (1956) BEHAVIOR OF THE ORGANISMS INFLUENCED BY VAR IOUS PUSTICIZr.RS. (toxicity studies) G. Eornmann et al. Z. LEBENSKITT-UNT2RSUCH 102, P. 413 (1956) PROPOSALS FOB EVALUATION OF SYNTHETIC MATERI ALS USED IN THE FOOD INDUSTRY. (Identifica tion of plasticizers and stabilizers for packaging films, and_evaluations of their toxicity) M,, Staub.- MITT. LEBENSM. HYG. 4g, p. 1 (1958) " THE TOXICITY OF PLASTICS MATERIALS. PACKAG ING 41, No.- 342, p. 72 (December 1958) TOXICITY EXAMINATION OF PVC FOILS. 0. Berndt. PLASTE u. KAUT. 6, Mo. 7, p. 347 (July 1959) INVESTIGATIONS OF THE TOXICITY OF POLYVINYL CHLORIDE STABILIZERS. I. V.. Nebel Ic O.R. Klimmer. ARZNEIMITTEL-FORSCHUNG 10, No. 1, p. 44 (January i960) THE TOXICITY OF PLASTICS, (especially lead stabilizers) S. F. Chancellor. NATURE 185, No. 4716, p. 841 (March 19, i960) PLASTICS. (Review of toxicity references) R. H, Wilson & W. E. McCormick. ARCH. IND. HEALTH 21, No. 6, p. 536 (I960) THE TOXICOLOGICAL PROBLEMS OF PLASTICS USED IN FOOD PACKAGING. IND. PLASTIQUES HOD, 12, P, 59 (June i960) CHRONIC TOXICITY STUDIES ON TWO EPOXIDIZt SOYBEAN OILS IN THE RAT AND DOG. P. 5. Larson et al. TOXICOLOGY & APPL. FHAF.hacg; OGY 2_, No. 6, p. 649 (November, i960) THE ACUTE TOXICITY OF THE TRIARYL FHOSPHAT USED AS PLASTICIZERS. H. F. Bondy et al, BRIT. J. IND. MED. 17, p. 130 (I960) PHYSIOLOGICAL AND TOXICOLOGICAL PROPERTIES, (Toxicity of vinyl resin stabilizers) R. Lefaux. PUSTIC'JES INFORMATIONS 12, No. 257, p. 4 (196I) SANITARY-CHEMICAL STUDY OF PVC-COATED FABRIC N. I. Slepak. UCH. ZAP. MOSK. NAUGH, ISSLED. INST. GIGIENY, No. 9, p. 121 (19&1) THE TOXICITY OF RIGID PVC DRINKING WATER CON DUITS. A. Rodeyns. REV. BELGE MAT. PLASTI- QUES No. 1, p. 17 (January 1962) TOXIC AND HEALTH EFFECTS OF PLASTICS AND RESINS. J. A. Zapp. ARCHIVES ENVIRONMENTAL HEALTH 4, p. 335 (March, 1962) A MINIMUM STANDARD TO MAKE PLASTICS SAFE IN MEDICAL APPLICATIONS. Dr. John Autlan. PLASTICS WORLD 20, No. 3, p. 12 (March, 1962) HEALTH AND SAFETY IN THE PLASTICS INDUSTRY. D. Kenwln Harris. FUSTICS INST. TRANS. ^0, No. 86 (April 1962) THE PROBLEM OF NON-TOXICITY OF ADDITIVES IN THE DOMAIN OF FUSTICS. E. EeClerc. IND. PUSTIQUES MOD. 14, No. 10, p. 37 (Dec. 1962) 48. VISCOSITY & FLOW PROPERTIES MEASUREMENT OF THE FLOW TEMPERATURE OF THERMOPUSTIC MOLDING MATERIALS. L. W. A. Meyer. A.S.T.M, BULL. No. 105, p. 23 (August, lg40) FLOW TEMPERATURE OF THERMOPUSTICS. L. W. A. Meyer. MOD. FUSTICS 18, No. 4, p. 59 (December 1940) FLOW PROPERTIES OF THERMOPUSTICS. I. W. G. Wearmouth & J. S, Small. BRITISH FUSTICS 12, No. 144, p. 377 (May 1941) WORKING-RANGE FLOW PROPERTIES OF THERMO PUSTICS. F. E. Wiley. IND. ENG. CHEN. 22, No. 11, p, 1377 (November, 1941) SOME RHEOLOGICAL PROPERTIES OF POLYVINYL CHLORIDE. L. Bllmes. J. SOC. CHEM. IND. 63, No, 6, p. 182 (June 1944) HIGH TEMPERATURE, HIGH PRESSURE RHEOMETER FOR FUSTICS. H. K. Nason. J. APPLIED PHYS, 16, No, 6, p. 338 (June 1945) RHEOLOGICAL PROBLEMS IN THE PROCESSING' OF FUSTICS. R. Buchdahl Ic H. K. Nason. IND. ENG. CHEM. 40, No. 4, p. 642 (April 1948) VISCOEUSTIC PROPERTIES OF SEVERAL HIGH POLYMERS. M, Horio et al. J, APPLIED PHYS, 22, NO. 7. P. 966 (July 1951) RHEOLOGY AND THERMOPUSTICS. E. B Atkinson & H. A. Nanearrow. FUSTICS INST.,TRANa. 524 12, No. 38, p. 23 (October, 1951) APPLICATION OF NUTTING'S EQUATION TO VISCO EUSTIC BEHAVIOR OF CERTAIN POLYMERIC SYSTEMS. R. Buchdahl Ic L. E. Nielsen. J. APPLIED PHYSICS 22, No. 11, p. 1344 (November, 1951) THE EUSTIC-VISCOUS BEHAVIOR OF PUSTICIZED POLYVINYL CHLORIDE AT ELEVATED TEMPERATURE. W. Tsujl Ic K, Shlozawa. BULL. INST. CHEM. RESEARCH, KYOTO UNIV. 27, p. 67 (1951) TWO EXTRUSION PUSTOMETERS FOR USE WITH POLY VINYL CHLORIDE. R. Hayes. FUSTICS 17, No. 177, p. 104 (April 1952); and Ch'EM. & IND. (1952) p. 421 and p. 1069 VISCO-EUSTICITY OF HIGH POLYMERS. II. KINETIC BEHAVIOR OF PUSTICIZED POLYVINYL CHLORIDE NEAR THE TRANSITION POINT. S. Nohara it S. Ouchl. CHEM. HIGH POLYMERS (Japan) 10, p. 286 (1953) POLYVINYL CHLORIDE RESIN. IV. VISCOMETRIC STUDIES OF MASTICATED PVC, K. Goto et al. CHEM. HIGH POLYMERS (Japan) 1^, p. 437 (1954) A KINETIC INTERPRETATION OF THE RHEOLOGICAL BEHAVIOR OF HIGH POLYMERS. Junjl Rurakawa, J. POLYMER SCI. 15, No. 79, P. 193 (January 1955) INTERPRETATION OF BROOKFIELD VISCOSITIES. R. L, Bowles, R. P. Davie it W, D. Todd. MOD. PUSTICS No. 3, p. 140 (November, 1955) OLI 2583 world est pvc filt rs purify wastewater ,gfgQst installation ot polyvinylehloride trickling filters will soon be purifying wastewater at Stockton, Calif. Filters are being supplied by B.F. Goodrich, Akron, Ohio, in a $2million contract. The contract, says Earl D. Gunn, president of BFG General Products Co. is a record for BFG Koroseal vinyl-core wastewater purification filters. He said that nearly 1.5 million cu ft of the product will be needed to fill three towers, each 22 ft high and 166 ft dia. These are taking the place of three rock filters in an expansion and upgrading of the main municipal water quality-control plant at Stockton. The vinyl-core filter packs are each 2 by 2 by 4 ft. Component parts of the filters will be made from Koroseal PVC com pounds at the company's plant in Marietta, Ohio, and shipped to the BFG plant in Modeston, Calif., for assembly. 1L July 2, 1973 CAEN A new polystyrene formulation doubles the life of injec tion-molded phonograph records, according to the formulator, Richardson Co., Des Plaines, 111. At present, about half of 45-r.p.m. records are compression-molded from polyvinyl chloride; the rest are injection-molded from less costly (but heretofore less durable) polystyrene. Richardson says its new low-wear polystyrene will open up new opportunities in the PVC half of the phonograph record market. CAEN June 25, 1973 World demand for polyvinyl chloride and high-density polyethylene is rising so fast that Belgium's Solvay & Cie. expects to have no problem selling all the output of its currently expanding capacity, Solvay chairman Jacques Solvay says. Solvay will complete a 200,000 metric-ton-a-year vinyl monomer plant at Rheinberg, West Germany, next year to bring its worldwide capacity to 850,000 metric tons, with PVC capacity about the same. And plant expansions in France, Italy, and Brazil will lift the company's high-density polyethylene capac ity from 150,000 to 200,000 metric tons a year by the end of 1974. Search, 1J3/ Apr.-May 1973 / 682 JAPAN . TOYA, TEKKQSHA Offer Hjgb-Irapact PVC Toyo Soda Co and Tgkkosha Co have jointly developed a new shock resistant grade of polyvinyl chloride. The material Is produced by graft polymerizing an oleflnic resin on PVC and Is recommended for molding pipes and similar products. (C) (Plastics Industry News 2-73 p 28) CAEN July 9. 1973 Effect ofvinyl chloride on the health of those who have worked with the material is the subject of a survey being administered by the Manufacturing Chemists Associa tion and carried out by Tabershaw-Cooper Associates. Sponsor of the study is a group of chemical companies that handle vinyi chloride. Another study at Industrial Bio-Test Laboratories is determining effects on labora tory animals of long-term exposure to vinyl chloride vapors. The studies will supply data for the National Institute for Occupational Safety and Health. LI 2584 " s"lc,r* * OtrjNi'-e utrtNTiM Ptm,ot oni OTM r * U ULi.f' Nsiv ftsai on PVC? A warning on poKvinyl chloride pack aging was given in Uic Nov. 5 issue of the Journal of the American Medical Assn. Three women who wrap meat, an article stated, developed severe respiratory problems following exposure to fumes produced by cutting PVC film with a hot wire. "We are reporting these cases because we suspect the phenomenon is not un common," contended the three Califor nia physicians who authored the article. The workers, all middle-aged and all smokers, developed symptoms such as shortness of breath, coughing and wheez ing, which resembled an asthma attack, according to the doctors. The discomfort cleared up when the women left the packaging room, but they had respiratory problems when wrapping meat with some other materials, the doctors said. The difficulty could stem from the plas ticizer or stabilizer used in making the PVC filnt, Union Carbide speculates. The heat might have volatilized some of the materials in the film, the company theo rizes. Carbide says it is a large producer of PVC resins but that ils major outlets for them do not include food packaging. This is not the first time that questions have been raised about PVC packaging. A few months ago the Food and Drug Administration temporarily banned molded PVC bottles for liquor because of concern about monomer migration into the liquor. Moreover, had FDA not acted on PVC liquor bottles, the Environmental Protec tion Agency was reported ready to submit "new evidence" that a substantial in crease in the use of PVC in packaging would be harmful to the environment. 77-;/ Nov. 26,1973C&EN New syndrome (aid to PVC meat-wrap film Polyvinyl chloride film is the suspected cause of an apparent new syndrome, meat wrapper's asthma, turned up bv William N. Sokol, Yosscf Aelonv. and Gildon N. Beall of Harbor Gen eral Hospital. Torrance, Calif. (Beall works also at the school of medicine, University of Califor nia, Los Angeles.) The three physicians tel! all in the Nov. 5 issue of the Journal of the Amer ican Medical Association. Their evidence comes from three fe male patients, ages 40.45. and 64, employed as meat wrappers. The three suffered severe respi ratory problems following expo sure to the fumes produced by cutting the PVC film with a hot wire. The patients' symptoms-- shortness of breath, coughing, and wheezing--appeared soon after the supermarkets where they wrapped meat switched to PVC film. In their six to 10 years of wrapping experience, the ladies had not previously been thus afflicted--notwithstanding the facts that the wTapperies were crowded, not specially ven tilated for fume removal, and chilled to about 52* F. Two of the patients show symptoms only when exposed to the PVC fumes; the thud was that way at first, but now has chronic short ness of breath (dyspnea) "and produces sputum." What with one thing and an other, the three Torrance doctors are highly suspicious of the PVC film. They don't know how wide ly the s> ndrome occurs, hut sus pect it i not rare. In fart, the manufacturer of the fit m--(he same product was used by all three patients--had had reports from several cities of respiratory problems associated with PVC film in meat wrapping opera tions. Thus alerted, the compa ny had already completed a study of the matter. Manage ment had PVC film pyrohrert determined the composition of the resulting gases, and conclud ed that they offered no hazard to meat wrappers. (The thought process that led to this conclu sion must have been reasonably sophisticated, but the JAMA ar ticle gives no details.) The three doctors were unlujled by the fact that hydro chloric acid occurs naturally in the stomach. They note that it occurs also in the combustion products of PVC, is a bronchial irritant, and "could conceivably cause the patients' symptoms." Despite the uncertainty over causes, however, they are in no doubt about the syndrome. "... it seems advisable," they write, "to call this matter to general attention to gain some idea of its prevalence___ " OLI 2585 CANCER DEATHS AMONG Pt?C January 30, 1974 CHEMICAL WEEK WORKERS CAUSE CONCERN i ? Long-existing concern over possible . health hazards to workers in firms - making polyvinyl chloride and vinyl chloride intensified dramati* cally last week with a disclosure ,4 that indicates there may well be a serious occupational disease prob* 1 lem--one involving cancer. 1 B. F. Goodrich Co. voluntarily . revealed to federal and state offii cials that since 1971 three blue-col. lar workers at its PVC resins plant s at Louisville, Ky., have died from a very rare form of liver cancer, two in 1973 and one in 1971. The can cer--angiosarcoma--is so rare that - federal authorities estimate that deaths throughout the U.S. from this cause total only 21 per year. Alerted to the deaths, federal ex perts and safety inspectors rushed within 48 hours to the plant. Dr. Marcus M. Key, director of the Na tional Institute for Occupational Safety and Health, says that his agency will step up its effort to de termine the extent of the disease in the U.S. and in foreign countries with similar manufacturing pro cesses. NIOSH plans to develop, on a crash basis, criteria for stringent work practices for use in the polyvi nyl chloride process. An agency spokesman tells C&EN the criteria might be ready in several weeks. The deaths were among BFG employees who worked in some phase of the PVC polymerization operation, but not in drying, fin ishing, or other areas. They had worked for BFG for 15 to 28 years. Dr. Maurice N. Johnson, BFG's director of environmental health, stresses that the causes of death are subject to verification and that the company is probing to see whether they are occupationally linked. Neither company officials nor federal experts are certain now what the suspect carcinogen may be, if the deaths are due to job ex posure. And apparently there is no violation of the federal standard for exposure to vinyl chloride vapors of 500 p.p.m. of vinyl chloride on a time-weighted-average basis. BFG says maximum exposures in its plants have ranged from 50 to 100 p.p.m,, with possibly higher expo sures but not for long periods. Dow Chemical, a major vinyl chloride maker, urged use of a 50p.p.m. exposure level in the litera ture in 1961 and adopted it as a company standard some 15 years ago. Regular physical examinations for Dow workers support the safety of this level, says Dr. Etcyl H. Blair, health and environmental re search director. But last summer Dow warned all of its U.S. vinyl workers of a "potential problem," based upon results of an Italian re search study that found tumors in rats administered 30,000 p.p.m. of vinyl chloride. To its credit, BFG's voluntary alert is the first such notice ever made to NIOSH by a firm for a se rious health problem. But the ensu ing probe seems likely to shake op erators of the 36 existing PVC resin plants in the U.S, as well as anoth er 14 vinyl chloride plants. i i Probing cancer deaths Three cancer deaths of B.F. Goodrich employees have sparked an intensive in vestigation by the company. The probers want to find out whether workers are being exposed to a cancer-causing agent at Goodrich's Louisville, Ky., plant. The employees had worked in the plant's polyvinyl chloride operations and all died of liver cancer tentatively diagnosed as angiosarcoma. All three died within a 27month period--one in Sept. '71, another in Mar. '73, and the third in Dec. '73. Goodrich reported its investigation to Kentucky health officials and the Na tional Institute of Occupational Safety and Health after a company physician learned of the deaths late in December and suggested a possible relationship. NIOSH and the Kentucky Dept, of La bor, charged with insuring Occupational Safety and Health Administration com pliance in the state, have since sent in vestigators to the plant. NIOSH also may visit other PVC plants to evaluate expo; sure standards. Goodrich said last week that it has re duced worker exposure to hydrocarbons, particularly vinyl chloride and polyvinyl chloride, to one-tenth of the specified federal standards. So far, this has not in terfered with the plant's level of produc tion, the company says. In addition, the company is providing medical examinations for all employees involved in any phase of vinyl chloride or PVC production and is checking the medical records of other deceased work ers involved in those operations. A NIOSH spokesman remarks that it's very unusual for three people who worked in the same area to die of angio sarcoma of the liver within such a short period. He notes that the nationwide inci dence of death from this cause last year occurred at a rate of only 21 per year. 6 C&EN Jan. 28, 1974 OLI 2586 Wall .StJ_JJ_ Three Cancer Deaths May Be Job-Related, B.F. Goodrich Says *o# Former Employes at Louisville Plant All "Were Involved in j Polyvinyl Chloride Operation Du it Wall Street Joi'RN.w. Stuff h'( f>vrln- AKRON, Ohio - B. F. Goodrich Co., In a move that sent ripples through the plastics and chemicals industries, stud it is investigating the possioility that the cancer deaths of three workers at a plant in Louisville, Ky., may be job-related. Goodrich said that the workers affected were in its polyvinyl chloride operations, and that they died of angiosarcoma of the liver, a rare form of liver cancer. Dr. Maurice N, Johnson, Goodrich's direc tor of environmental health, said in the compa ny's statement that he had recently received medical reports concerning the death of an em ploye in late December. "A review of medico' records uncovered that two other employes had apparently died from the same cause-one in September 1071 and one in March 1973," the company said. It was understood that a fourth death-in 1933-involving a more common form of liver cancer was considered outside the reasonable bounds of the "grouping" of the three recent deaths, all attributed to angiosarcoma. Goodrich said it had informed Kentucky health officials and the Federal National Insti tute of Occupational Safety and Health that the company was investigating the possibility that the deaths might be "related to occupational causes." Will Begin Investigation Kentucky officials said they had just learned of the situation at the Louisville plant and had asked a medical expert to investigate. In Rockville, Md., a spokesman for NIOSH said a team of experts will arrive in Louisville this morning-to begin an investigation. Dr. Marcus M. Key, director of NIOSH, said the institute also will step up efforts to deter mine the extent of angiosarcoma in the U.S., and in foreign countries with similar manufac turing processes. A spokesman for the institute said the best information available shows 21 deaths per year in the U.S. attributable to an giosarcoma. The recent deaths at Louisville, according to Dr. Johnson of Goodrich, involved workers in the company's vinyl products operations. An official of NIOSH said he understood that the workers had an average of 20 years' exposure to various chemicals and agents involved in vinvi operations. Goodrich .-me! it h',s been conducting a r.ro- gr.t.:'. to redact fb hydrocurtasm. p, tiruiur'y v,r,y! i ,i--i .>' 1 !) i-gi-cut :;s dicta tions. Ftr tlier stop- to limit expot i re and to describe the skuuLion to workers m vinyl pioduets production ere being taken, the company said. Goodrich also said it is providing medical examination;; to all employes involved in any phase of vinyl chloi idc or polyvinyl chloride production, and is reviewing all its medical records of former or retired employes. About 3.200 persons work at the Louisville plant, of whom about 270 are involved in vinyl products operations. "Dropping of a Bomb" Word that the deaths might be job-related spread quickly throughout several industries. Kind Louis Belicxky, an industrial hygienist on the staff of the L'nited Rubber Workers union, which has many members involved in vinyl operations at various companies: "I look at this as the dropping of a bomb. It opens up the possibility of a whole new occupational dis ease." Mr. Beliczky said he suspected there might be a connection between the Goodrich prob lems at the Louisville plant and the problems of Borden Inc. at a vinyl-materials plant in Co lumbus, Oliio. Workers at the Borden plant for several months have complained of a variety of ailments, some believed crippling, which they allege are connected with working condi tions. Rudolph Kaelin, president of the Synthetic Rubber Workers unit representing the Ken tucky plant's workers, said some of his cowork ers "have been concerned for quite a while" about the possibility of cancer. "With these men dying of it, it makes you wonder." Mr. Kaelin says he has worked with vinyl products for about 15 years; he has been a Goodrich em ploye for 23 years. A medical expert at NIOSH, however, said he doubted the difficulties at the two plants were related. He asserted that the problem at the Borden plant has been defined as periph eral neuropathy, a disease that attacks nerves that control muscles in human limbs. The liver afflictions at the Goodrich plant seem unre lated to the problem at Borden, he said. Goodrich has four other polyvinyl chloride plants-at Avon Lake, Ohio, Pedricktown, N.J,; Long Beach, Calif., and Henry, 111. T SI OLI 2587