Document M7QpQOxmo6Zka5V5zwQ7v4ok

UNIVERSITY OF CINCINNATI CINCINNATI 1 9 . OHIO Decem ber 2 3 , 1943 CABLE ADDRESS: KETLAB. CINCINNATI TELEPHONE: UNIVERSITY 2 6 6 5 En clo se d p le a se fin d a p r e lim in a r y d r a ft o f a p a p e r on "The E f f e c t o f Le a d E x p o s u r e , Le a d P o is o n in g , an d BAL on t h e Co n c e n t r a t io n o f Le a d i n Human P la s m a ." Th is is th e f i r s t o f a p r o je cte d s e r ie s o f papers based on t h e d a t a t h a t h a ve b.een a ccu m u la t e d in t h e La b o r a t o r y o v e r t h e la s t 15 y e a r s . . ' The n e x t p a p e r w o u ld be on "The F a c t o r s E f fe c t i n g t h e Co n c e n t r a t io n o f Le a d in t h e E r y t h r o c y t e s a n d t h e U r i n e ." We have s u f f i c i e n t d a t a on t h e f e c a l c o n c e n t r a t io n .o f le a d t o w r it e a p ap er on th e t o t a l m e tab olism u s in g c e r t a in o f t h e gr o u p s o f man we h a ve s t u d ie d . A s u b s e q u e n t p a p e r w ou ld d e a l w it h c l i n i c a l le a d p o is o n in g . We w ou ld d is c u s s th e symptoms o f le a d in t o x ic a t io n , t h e s ig n s , and th e a s s o c ia t io n b e t w e e n t h e s ig n s an d sym p tom s. The fa c t o r s e ffe c t i n g gr ou p and in d iv id u a l s u s c e p t i b i li t y w ould be measured and d iscu sse d . The e ffe c t o f t h e r a p y , in c lu d in g r e m o v a l fr o m e x p o s u r e , BAL, c i t r a t e , c a lc iu m , sod iu m ammonium c h lo r id e , sodium b ica r b o n a t e and p o t a s s iu m io d id e and co n co m it a n t d is e a s e w ou ld b e , in la r g e p a r t , q u a n t it a t iv e ly a ssa ye d , th e co m p lica tio n s and cou r se o f le a d p oison in g w ou ld co n clu d e th e p a p e r . The l a s t p a p e r w ou ld be on t h e c o n t r o l o f le a d p o is o n ir ig . T h is w ould c o n s is t o f two p a r t s , t h e f i r s t , th e p r e ve n tio n and th e p a r t p layed by th e la b o r a t o r y and c lin ic a l fin d in g s ih a id in g in th e p r o p h y la xis , and secon d , t h e t r e a t m e n t ,in w h ich t h e r e l i e f o f t h e symptoms and t h e e ffe c t o f d e le a d in g p r o ce d u r e s w ould b e d is c u s s e d . U n fo r t u n a t e ly , i t w i l l n o t be p o s s ib le f o r me t o w r it e t h e s e p ap er s b e fo r e th e f i r s t o f th e ye a r a s I had I^ p N 6253 Dr Ro b e r t A . Kehoe 2- Decem b er 237,1 9 4 &. -* o r ig in a l l y p la n n e d t o d o . W h ile I am d is a p p o in t e d . I am n o t t o o s u r p r is e d b e ca u s e i t h a s t a k e n me a lo n g t im e and stu d y a lo n g d eviou s p ath s to ge t th e c lin ic a l and s t a t is t ic a l b a ckgr o und to p r o p e r ly in t e g r a t e th e m a g n ifice n t d a t a w hich i s in o ur h a n d s . I t h in k t h a t t h e f i r s t p a p e r , w h ich I am e n d o s i rig h e r e w it h , i s a good e xa m p le o f t h e u n iq u e v a lu e o f th e s t a t i s t i c a l m ethods w hich I have a p p lie d t o th e d a t a . I t w ou ld be w it h g r e a t r e lu c t a n c e t h a t I w ould le a ve th e work in t h is p r e se n t u n fin is h e d s t a t e . In th e f i r s t p la c e ,I t h in k th e work sh ou ld be done b ecau se I t h in k i t w i ll pr ove to, be th e m ost a u t h o r it a t iv e and v a lu a b le work t h a t hais y e t b e e n done in t h i s f i e l d . In t h e s e co n d p la c e , I d o n ' t t h in k t h a t a n yb o d y e ls e b u t me h a s t h e t im e , t h e background and th e u n d er stan d in g o f th e s t a t is t ic a l methods t h a t ar e n e ce s s a r y to com p lete th e s t u d y . In th e t h ir d p la c e , I h a ve s p e n t a v a s t amount o f t im e in le a r n in g how t o t a c k le t h is p r oblem an d t h is tim e w ould be w asted i f I co u ld n ot fin is h i t . L a s t l y , my s c i e n t i f i c r e p u t a t io n depends la r g e ly on th e q u a lit y o f th e work th a t I p u b lish and t h is r e p u t a t io n is o f th e utm ost va lu e t o me. I t h in k i t w ould t a k e a t le a s t s e v e r a l m onths an d p r o b a b ly h a l f a y e a r f o r me t o f i n i s h t h i s p r o je c t i f I co u ld sp en d a s much t im e on i t a s I h a ve in t h e l a s t y e a r . I w ou ld l i k e t o know i f you a g r e e w it h me t h a t t h e w or k sh ou ld be done and t h a t I sh ou ld do i t . Some t im e b e fo r e t h e f i r s t o f t h e y e a r I w ou ld a l s o lilc e t o know i f a n y t h in g h a s come o f t h e p r o je c t e d s t u d y iri t h e f i e l d o f r e s p ir a t o r y d is e a s e t h a t you m e n t ion e d t o me e a r l i e r in t h e m o n t h . Sin ce r e ly you r s, He n r y W. Ry d e r , M.D.