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by gasolin e known th a t burns :o f the sk in are produced^ p e r s is t e n t and recu rren t d e r m a titis i s n o t re c o g n ise d by more than a few g a s o lin e d is t r ib u t o r s to be an o c c a sio n a l consequence of rep ea ted arid r e g u la r co n ta ct o f the sk in -w ith ..g a s o lin e . During th e p a st f i f t e e n years s in c e the in tro d u ctio n of"-leaded-'gasoline 'into- commercial u s e , a number :o f cases,, e n tir e ly ty p ica l of the e f f e c t s of the in halation of to x ic concen tration s o f g a so lin e , as w ell as others ch a ra cteristic of the r e su lts o f sk in c o n ta c t hare been brought to my a tte n tio n by r e p r e se n ta tiv e s o f g a s o lin e d is t r ib u t o r s who were not aware th at g a s o lin e cou ld produce such e f f e c t s , and who thought th e se m ight be ca ses o f le a d p oison in g among g a s o lin e h a n d le r s. I have a ls o seen a few ca ses of i l l n e s s among persons who have swallowed g a s o lin e in sip h on in g from a f u e l tank or o th e r w ise . Here the symptoms were th ose o f the In ten se g a s tr o -in te s tin a l ir r it a t io n c h a r a c te r is tic cf g a so lin e e f f e c t s , a s s o c ia te d w ith some degree o f g e n e r a l in t o x ic a t io n where a p p recia b le g a s o lin e a b so rp tio n had occu rred . In no in sta n c e was th ere evidence o f lead in t o x ic a t io n , nor would any such r e s u lt be exp ected i f one took the trouble to ca lcu la te the q u a n tities of lead in gested with the g a s o lin e . Indeed, we may d ism iss the e n t ir e m atter o f any p e c u lia r ly to x ic p rop erties of commercial leaded g a so lin e , as d if fe r e n tia te d from corresponding non-leaded g a s o lin e , by p o in tin g out that nelthermy a sso c ia te s nor m yself have seen or have been able to find evidence of the occurrence of a sin g le case of lead poisoning or o f lead absorption from skin con tact w ith or in h a la tio n o f leaded g a s o lin e among the thousands o f persons a t r e fin e r y lo a d in g racks and f i l l i n g s t a t i o n s , o~ among tank-wagon d r iv e r s and other h and lers o f la r g e and sm a ll q u a n titie s o f g a s o lin e . Our f i e l d s t u d ie s and the experim ental o b serv a tio n s which provide an e x p la n a tio n o f the non-injurlcm s e ffe c ts of commercial concentrations of Ethyl F luid
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