Document M4xRgRoe5z7Ypp1z5qvjXE4zx

HANDBOOK of INDUSTRIAL TOXICOLOGY by E. R. PLUNKETT, M.D. Industrial Health Services Barberton, Ohio CHEMICAL PUBLISHING COMPANY, INC. New York 1966 UCC 022483 UCC 022484 ppm of air 36 l nervous system d cells by reduction in glutathione s and nephritis tidneys May be delayed up to two days) Garlic odor of breath Numb ing of hands and feet Nausea, al cramping - Abdominal tender Weakness Bronzing of skin ing) Pulmonary edema Jaunegaly - Hematuria, hemoglobinand oliguria - Anemia and leukoblood calcium Increased blood ck Delirium and coma ilevation of T-waves in all leads jr more with normal conduction /$ 0.2 mg/liter g body weight (but not to exceed dose) every 4 hours the first day; econd day; then 3 times daily for week mulation in patients with reduced ; blood and packed red blood cells pportive ;urs is usually complete rline respirator 37 ARSINE Periodic examinations of urine should not exceed 0.5-1.0 mg arsenic/liter of urine \ Preclude from exposure those individuals with diseases of blood, liver, kidney, and central nervous system ASBESTOS Synonyms: Amianthus - Amphibole Chrysotile Earth Flax Impure Magnesium-calcium Silicate Mountain Cork Serpen tine Stone Flax Many mineralogical names Description: Flax-like fibers; fireproof Occupational Exposure: Clutch facings and brake linings Roofing and insulating materials Asbestos cloth products, valve packings, gaskets, pipe cover ing Auto undercoatings Threshold Limit Value: 5 million particles/cu ft of air Toxicity: Arsorption; Inhalation Pathology: Asbestos warts, from fibers that penetrate epidermis Pulmonary interstitial fibrosis via mechanical action of long fibers (20-50 microns) in terminal bron chioles Grade I: Asbestos bodies in alveoli Grade II: Asbestos bodies * Thickening of alveolar walls Perivascular fibrosis Grade III: Coarse honey-combing of lungs Scar ring in upper portions * Thickening of Pleura Adhesions Benign asbestos pleurisy may occur without other significant pulmonary disease Signs and Symptoms: Anorexia Cough * Dyspnea Loss of weight Pallor Weakness - Cyanosis Clubbed fingers Decreased vital capacity UCC 022485 ASBESTOS 38 Diagnostic Tests: , Asbestos bodies in sputum X-ray changes after 10 years or more of exposure: Stage I: Increased density at both bases with an occasional superimposed granular pat tern Apices dear Stage II: Decrease in clarity of cardiac silhouette Densities extend to the periphery of mid dle and lower thirds of both lung fields --"ground glass appearance" Accentuation of hilar markings Stage III: Shadowing of middle and lower thirds of both lung fields Cardiac shadow obscured--"shaggy heart" Treatment: Symptomatic and supportive Disability: Disease ceases to progress on cessation of exposure Question of cancer not yet answered Preventive Measures: Adequate ventilation Wet methods * Mechanical filter respirator Physical examinations of exposed personnel annually, in cluding vital capacity measurements and chest x-rays Preclude from exposure: Persons with pulmonary disease Persons under 40 when diagnosis of asbestosis is definite Persons in whom disease is progressing, regardless of age ASPHALT Synonyms: Asphaltum Bitumen Earth Pitch Mineral Pitch Petro leum Pitch Description: Brownish-black solid Occupational Exposure: Insulating Paving Roofing Waterproofing Paints and varnishes Wood impregnation Threshold Limit Value: None Toxicity: Absorption: None Pathology: Local iriitani Signs and Symptoms: Acne-like lesions and Tar melanosis: yellow skin Irritation of eyes and : Diagnostic Tests: None Treatment: Remove by scraping, o Symptomatic and sup Disability: No permanen Preventive Measures: Loose clothing, closed at n US Protective goggles Personal cleanliness m Synonyms: v Pyoktaninum laureum Py : aminophenyl) methylene zophenonimide Description: Yellow flakes or pi Occupational Exposure: Antiseptics Dyes Threshold Limit Value: None Toxicity: Arsorption: Inhalation Pathology: Sensitizer Tumors ir Signs and Symptoms: v Dermatitis and burns ing Yellow vision UCC 022486