Document M4b6n1nNK57Jn2VKyjEDdX4Ra

001117 CONFIDENTIAL CO WORLD REGISTER OF CASES OF angiosarcoma OF LIVER CA S L) THE REVIEW DATE 1 JANUARY 1988 ********* Collated by: Dr Brian Bennett Occupational Health Department ICI Chemicals and Polymers Limited Hillhouse Site PO Box 4 Thomton-Cleveleys Blackpool FY4 4QD England (Telephone (Telex (Facsimile 0253 861632 ) 67483 ICIPLHG) 0253 861861 ) LIVER AfCIOSAROMA CASES CCRFUSNTLAL FEBRUARY 1988 dRCULATICN OF REGISTER BAGSHAW Dr I MM BAM) Dr P R BARON Dr C BARRAT Dr G BAXTER Dr Peter BAYLAC Dr BEAUPRE M BELLEC Dr BENECH Dr M BENNETT Dr B BEKEAZZI Dr P BISHOP Dr C BORRELLI F E BOYER R W BRAUN Dr C L J BREWER Dr M BRYSON Dr D D BURtESS Mr David BYREN Dr David CARTER Dr J T CAIAJEARITI A CELLA Mr C CHANCE Mr M CLARKE Dr E A CLAUS Mr P G CLAYTON Mr H CONTASSOT Dr J C DAVIES Mr J G DEJONG Dr G DELORME Dr F DEPLAN Dr DE VOS Mr A J DIETZ Dr H W DOLL Sir Richard DOMBROWSKI S L DRLMWRIGfT Dr J R DUPONT Mr G EMMINEER Mr H ERNST Dr W EVANS Dr A E J FALK, Dr H FAVRE Dr FERGUSON Dr D M FINCHAM Ms Shirley FORMAN Dr D FRA5E R W FRIEDEL Dr H P GOSZICNYI Jnr Dr GOTTEEMAN R T HARRIS Dr W D HENDERSON I B HILLMAN Dr D W HLNDERER Dr R K HOWARD Dr J K MMPHRY Dr N F JAUVERT Mr J JERVIS !t H R JONES Dr R D Norsk Hydro, Newtek Aycllffe, UK Cancer Control Agency of British Cblunbia, Vancouver, Canada ICI ftmcom, UK AECRP, Goomentry, France University of Canbridge, UK Atochem, Chauny, France Government of Ouebec Cancer Registry, Canada thone Poulenc, Aubervillers, France Naphtachimie, Lavera, France IQ HLUhouse, UK Inst of Occupational Health, Milan University, Italy EMAS, Cardiff, UK Georgia Gulf, Delaware City, USA Formosa Plastics, Delaware City, USA Akzo, Arnhem, Holland Inperial Oil, Sarnia, Ontario, Canada ICI BUUnghan, UK IQ Americas, Wilmington, Delaware USA Kemanord, Stockholm, Sweden EMAS, London, UK EVC, Brussels, Belgiun EVC, Brussels, Belgiun ICI Runcorn, UK Ontario Cancer Foundation, Toronto, Canada APPE, Brussels, Belgiun Norsk Hydro, Newton Aycllffe, UK Atochan, Saint-Fons, France ICI, Everberg, Belgiun Shell, An Den Haag, Holland Quebec, Canada Atochan, Jarrie, France EVC, Welwyn Garden City, UK B F Goodrich, Akron, Chio, USA Imperial Cancer Research Find, Oxford University, UK Dow Chemical, Midland, Michigan, USA Vista Chemical, Houston, Texas, USA AEME, Brussels, Belgiun VKE, Frankfurt, Germany Berufsgenossenschaft der Chsnischen Industries, Nurnberg, Germany Lever Bros, Warrington, UK Chronic Diseases Div, US Dept of Health & EUnan Services, Atlanta, USA Atochem, Montluel, France ICI Americas, Wilmington, Delaware, USA Alberta Cancer Board, Edmonton, Canada Imperial Cancer Research Rind, fcford University, UK DiversiTfech General, Akron, Chio, USA Berufsgenossenschaft der Chsnischen Industries, Heidelberg, Genany R E Termeco Chemicals, Plscataway, New Jersey, USA The Vinyl Institute, Vfeyne, NJ, USA Uniroyal Inc, Middlebury, Connecticut, USA ICI, HiUhouse, UK Diamond Jhanrodc Corp, Dallas, Texas, USA BF Goodrich, Qeveland, Chio, USA University of Otago School of Medicine, Wellington, New Zealand IQ Australia, Melbourne, Australia Chloe ChintLe, Paris, France ICI Millbank, Lorrion UK EMAS, Bootle, UK R&S 001118 WPX/ASL - ASL ADDRESS,I KAIFEBT Dr JH KARRH Dr Bruce KLEIN Dr H KREUGER Dr R A LAGAST Dr H LALOINE Dr J P UNHAM Dr John LANOUZIERE Dr LAWRENCE-JONES LEE Dr F I LELBACH Prof I* LEVHJQUE Dr G LEVISON Dr D A LEWIS Dr P LOLIVTER Mr LUSS R D LUSSATO Dr Josette MAHLARD Dr J M MALTDNI Prof C MARGEITS, Mr R J MATIRE Prof Lo MA3TTUSSI Dr R MIDDLETON D MDKXA Mr MONIESAND Dr R MOTTI Dr A A MJNOK MOUICN Dr M MaeSWQN Prof RIM NAKAMJRA Dr S OLSON H G CWEN Dr R PADDLE Dr G M PAGLIALUNGA Dr S PAQUET Dr PAIERSCN Dr J C PIRASTO Dr Roberta POPPER Dr Hans POSSBERG Dr J PUECH Dr A M PURDHAM Dr J RAMBAUD Dr J RICHARD Dr P ROBSON Mrs D RODRIGUES Dr MJF ROUSH Dr G RL7TY DT J SAIG Dr Joyce A SARAOCI Dr R SCHEFFERS Dr T M L SCHIFFER Dr H SERCRC Dr D SHAH Dr Has SIGRIST Dr J SMITH Prof Allan H SMTIH Dr E SMITH Hr J S SMTIH Dr P M SPIEEAS Dr R STAFFORD Dr J STAHNECKER Mr SULAIMAN Dr 2- - Dew Chanlcal Europe, Horten, Switzerland Dupont, Wilmington, Delaware USA Dynamic Nobel, Troisdorf, Germany BF Goodrich, Akron, Ohio, USA Solvay, Brussels, Belgian Solvay, Brussels, Belgian Daw Chanlcal, Midland, Michigan, USA Solvay, Tkvant, France Sir Christopher, Chief Medical Officer, ICI, London UK Victoria Hospital, Blackpool, Lancs, UK University of Bonn, Wtest Germany CDF Chimie, AZF, Bully-les-Mines, France St Bartholomew's Hospital, London, UK Chanlcal Industries Association, London, UK Solvay, Brussels, Belgian Occidental Chanlcal, Pottstow, Pennsylvania, USA Atochen, France Suva, Luzern, Switzerland Institute dl OncoLogla, Bologna, Italy ICI Directorate, Wilton HQ, UK Medil-Anlc-S, Milan, Italy Montedison, Milan, Italy Norsk Hydro, Newton Ayeliffe, UK Neste Oy, Espoo, Finland IARC, Lyon, France Duperial SAIC, Buenos Aires, Argentina Rio Rodano, Madrid, Spain Western Infirmary, Glasgow, Scotland Japanese PVC Association, Tckyo VC Safety Association, Louisiana, USA Trades Union Congress, Loreion, UK ICI Central Medical Group, Alderley Park, UK Montedison, Novara, Italy Atochen, Serquigny, France Id Runcorn, UK Istituto Superlore di SarrLta, Rone, Italy Mount Sinai Medical Center, New York, USA Ifecker-Chanle, Mmich, Germany Atochen, Brignoud, France Canadian Centre for Occupational Health & Safety, Hanlltcn, Canada FP Recherches, Antony, France Fhcne Poulenc, Roussillon, France Saskatchewan Cancer Foreidation, Regina, Canreia ICI, Sao Paulo, Brazil Monsanto, St Louis, Missouri, USA Atochen, St Auhan, France NIOSH, Cincinnati, USA IARC, Lyon, France DSM/CVM), Geleen, Hollared University of ffenltoba, Winnipeg, Chnada Dtanond Jhanrock, Dallas, USA CMA, Vhshlngton DC, USA Shell Chinde, Berre L'Etang, France University of California, Berkeley, USA Division of Environmental Health, World Health Organisation, Geneva, Swltzerlarei ICI Hlllhouse, UK Llandough Hospital, Penarth, UK NCI/NIH, Bethesda, Maryland, USA Somerset, UK BASF, Ludwigshafen, Germany Arabian PetrochenLcal Co, Saudi Arabia R&S 001119 WFX/ASL - ASL ADDRESS,2 3- - TACHECI Dr H TAMBURRO Prof ffl ten BERCE Dr W F TPUKHOFF Dr N TEPPER Dr L B TER HAAR Dr Gary TERWIESCH Dr B THERIAULT Dr Gilles IHIESS Prof Dr A M THHS-EVENSEN Dr E THOMSON Dr D H TONER H P VAN DER MERSE Dr H J WALLACE J R WALTEMA3E h WEJDLING S 0 WHITE K H WILINSKI 0 WIILIAMS Dr cm WILSON Prof R WRIGHT Dr A P YORK J Hoechst AG, Frankfurt, Germany University of Louisville, USA Dai, Geleen, ttollarei tills AG, Marl, Germany Air Products, Allentown, Pennsylvania, USA Ethyl Corporation, Baton Rouge, Louisiana, USA Chemische Werke fills, Kreis Recklinghausen, Germany McGill University, Montreal, Canada BASF, Ludwigshhafen, Germany Norsk Hydro, Porsgrunn, Norway Cancer Treatment & Research Foundation, Halifax, NS, Canada Society of the Plastics Industry, Washington DC, USA AECI, Sasolburg, South Africa Esso, Sarnia, Ontario, Canada BF Goodrich, Cleveland, Ohio, Usa Norsk Hydro, Stenungsund, Sweden Duperial, Buenos Aires, Argentina Electrochemical Industries, Acre, Israel fP Chemicals, Penarth, UK ` Harvard University, Cambridge, Massachusetts, USA IQ Wilton, UK ICT Everberg, Belgian From: Dr B Bennett, Occupational Health Department, IQ Chemicals & Polymers Group, Hillhouse Site, PO Box U, Thomton-Cleveleys, Blackpool FY5 4QD, England R & s 001120 WPX/ASL - ASL ADDRESS,3 CONFIDENTIAL REGISTER OF CASES OF ANGIOSARCOMA OF THE LIVEH DUE TO EXPOSURE TO VINYL CHLORIDE - REVIEW DATE 1 JANUAHY I988 PREFACE : ACKNOWLEDGMENTS, SIGNIFICANT CHANGES, COMMENTS AND REQUESTS 1 The 8 new cases in the Register are the following; Canada 11 and 12; France 22; Italy 06; Japan 03; UK 14; US 4o and 41 2 There are amendments from the previous Register against the following cases; Japan 01 and 02. 3 I would like to thank the following for informing me of new cases: Dr Delorme, Dr Contassot, Dr Chiozzini, Dr Nakamura, Dr Evans, Dr Williams, Dr Dietz, and Professor Tamburro. 4 For the case corrections I thank Dr Nakamura. 5 It will be noted that there are gaps in our knowledge of several cases, notably Canada 11 and 12 and US 4l. Also, so far as we know the following people are still alive; cases Canada 11, France 15 and 22, Germany 31 and 32, UK 14, US 33, 36, 41. Is this correct? This is important information for the industry world-wide and we would appreciate news. 6 I should be glad if all recipients of the Register would continue to keep me fully informed of any new cases, or give the name and address of someone who can give me the necessary details. I have again attached a blank sheet at the back of the Register so that information can be supplied under the appropriate headings, so far as possible. 7 As a result of the request sent with last year's Register, regarding Co-factors,we received a great deal of information about PVC Plants, which has resulted in many amendments to Tables 8, 9, 10 and 13. Further corrections will be appreciated, bearing in mind that the Tables are confined to PVC. 8 RESEARCH; (a) May I again ask that all individuals involved in relevant research keep me informed and if possible send me reports. Perhaps recipients of this Register would pass on my request. (b) Co-factors; In response to the questionnaire enclosed with the 198? Register, regarding possible co factors with Vinyl Chloride, I received replies from 26 Companies, covering 6l factories. This material is now being analysed by Professor Carlo Tamburro at the University of Louisville, Kentucky, USA, and we shall report on the results as soon as possible. We are extremely grateful to all who took the trouble to give this information. If any Company has not yet completed the Co-factor questionnaire I should be grateful if it could be completed and sent back to me as 6oon as possible. 9 I would also be glad of help to keep the mailing list correct and up to date, with news of retirements,etc. FROM; Dr Brian Bennett, Occupational Health Department, ICI Chemicals and Polymers Limited Hillhouse Site, P 0 Box 4, Thornton-Cleveleys, Blackpool, FY5 4QD, England February 1988 BB/BGS IZUOO S?u zzvioo s^a Index Table Sequence Be 1glum Canada Czechoslovakia France Germany Italy Japan Norway Sweden UK USA Yugoslavia Incidence o Cases per annum (Table 1) Distribution of Cases by Country (Table 2) Pattern of Cases by Factory (Table 3) Latency Periods (Table 4A) Distribution of Latency Periods (Tables 4B-4H) Annual Geographical Incidence (Table 5) ICI CHEMICALS A POLYMERS LIVER ANGIOSARCOMA CASES (REVIEW DATE - 1 JANUARY 1988) i ~" ' WPX/ASO - LANGIOCASES, A Page 1 2-3 4 5-9 10-15 16-17 18 19 20 21-24 25-32 33 34 35 36 ASL Case Numbers by year of Death (Table 6) ASL Case Numbers by year of first exposure (Table 7) Western Europe PVC Producers - Start-up Dates vs ASL Cases (Table 8) USA PVC Producers - Start-up Dates vs ASL Cases (Table 9) Canadian PVC Producers - Start-up Dates vs ASL Cases (Table 10) East European PVC Producers - Start-up Dates vs ASL Cases (Table 11) Japanese PVC Producers - Start-up Dates vs ASL Cases (Table 12) South A Central American PVC Producers - Start-Up Dates (Table 13) Australasian PVC Producers - Start-up Dates (Table 14) Middle Eastern PVC Producers - Start-up Dates (Table 15) Blank form for notifying new cases Page 46 47 48-49 50-51 52 51 54 55 56 57 - 37 38-44 45 J RKLGUJH ICE CHtHJCALS k POLYMERS LIVEH AnHloaarcoaa Cases - (Review Date s t January 1988) WPX/ASL - LANG1 OCASLb , 6 2 1 ____________ ! COUNTRY AND REFERENCE NO i NAME OX INITIALS 3i 1 i DATE OF l mm i i i ts _L t \ COMPANY \ FACTORY l 1 BELGIUM l 6 7| 8 1i 1 1 9 to 1i 12 13 14 1 1 i1 t1 FUST VC i DATE OP J ACE AT EXPOSURE i DIAGNOSIS J DIAGNOSIS i i! YEARS OF i YEARS OF DATE OF i HISTOLOGICAL 1 ESTIMATED EXPOSURE TO i EXPOSURE 1 DEATH i CONFIRMATION ( EXPOSURE i i OCCUPATION i i1 DIAGNOSIS i i l LEVEL i i X -L i 1j IS OTHER CAREER HIGHLIGHTS i i i 1 1 1 1 16 OTHER COMMENTS 01 02 SR 2 .CM . 11 J So I vay Jeae ppe 00.07.&8 | 00.03.76 \ 1 1 1 1 1 1 I 1 1 i 1 1 l 1 1 1 1 i t i i 1 1 1 J 1 1 1 1 t So Ivay Jeaeppe 1 I 20 08 62 I 00.10.79 1 1 1 1 1 1 { 1 1 t J I 2i J.QQ ssa 1 1 1 1 1 1 1 1 1 1 1 i i 1 i 1 1 t \ 1 i 1 1 i \ \ [ 1 i 1 1 i 1 1 I 1 1 J 1 1 1 1 1 1 1 I 1 1 1 J 63 J8 t i i 1. 39 D -- .. 1 n 129.06.76 i Yea l High lAutocleauer |0clller in a JiiepMt ir tel 1 11 1 |14 yta |foundry |In,0rl 1974 1 ti 1 1938-1968 1 1(2 IT.) (were norael. 1 ti 1 exposed to |Polyworker |Faraer 1 Re c1 red i ii 1 200 ppa t1 yra |(15 yra) t Feb 1975 1 ti I for B hra | |Work 1n glase t Hoapltallaed 1 ii i per day I tod. & cheat - IHay 1976 \ 11 1 and | |ce! Induetry i 11 1 certainly J JCoapleie 1 I1 i under \ JCHntcal and \ ii i 300 ppa i i (career detail* i \t t 1 n 6 to i i (are given In a t ii i 9a3 1 Ip.p.r by 1 it t autoclaveal | iHublet e( at 1 ii i 1968-1972 1 11n Arch. Re tg. 1 11 t exposed to| j |Ned. Soc. , 1 ii 1 50-200 ppa I | 1 Hyg. Med. 1 ii 1 8 hra per 1 ITrav. Hed. i ii i day in I ii*g- 1 ii t 23a1 1 |1977 page* \ ii 1 autoclaveal | 1601-622 1 ii 1i 1 i ii 1 ii 1 ii t exposed to| 1 50-200 ppa j 1 In auto- i J | 1 1 l 1 <i t clave rooal I \ 1 ii 1 1974-100 I 1 1 ii ) PP* I 1 i ii 1 1975- 50 j 1 t ii i Pf t 1 I ii 1 RETIRED i 1 i ii 1 1 Feb I973| | J i ii |1 1 I 1 11 1 9 123 10 83 I Yea ti 1 l 08.62-03. lAutocLeaner IFIreaan since |1 aC a Ign July 1 ii l 61 OJ.67 |5 yra 5 athv|10 71. ()9: Tbot.clc 1 11 i -10. M * lOperetor Ipaln 07.79. t ii 1 200 ppa |3 yra 9athx. |Hepatlet eat a 1 11 \ fth/day 1 tattered 10.79. 1 ii 1 04.63-12. 1 |Poa11 Iv* i ii \ 66 200 1 lectio^ r aptiy I ii 1 ppa 1 111.79. II. pa- t 11 11 (Cartnay 02.80. 1 11 t1 |(1]rant ht-f apy . 1 ii 1J 1(nforadt J ou 1 <i tJ igijpn in 1 Jl 1\ t lleitei U Nov 1 ii 1 i i __ 1 1 J \19fl4 | au Ur II . Sir nvi'l , wuoo S3U Page 2 CANADA Sfiret | COUNTRY AND REFERENCE NO NAME Oft INITIALS DATE OF BIRTH LIVER Angloaarcoaa Caeea - (Review Dale: I Jan 1986} UAY - MUNI H - YhAH wrMAbC - i ruu it hjcj ,, LO FACTORY FIRST VC EXPOSURE DATE OP DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS 16 tiniKK COMMENTS 15.12.11 ms 41 U2.0V.5S Reactor cleaner Operator polyaerfaat J<- 02 06.01.14 26.08*IV 05.04,19 2 I. I 2.57 194 I 1962 21. 03.62 1945 46 27 22 2 I.OJ.66 Hal (it ciuttct, Opef at or 1 Uwr Iglit , pi pef11 ter Wurked ov e r 11ue Snoker Opera!or, foreaan X Worked overtlae Non-aaoker Reactor cleaner Operator, foreman, water cool lag uni c WorkeJ overtlat> Ssok e c 07.05*11 1944 1966 1)5.07,66 React or c leaner Water cooling unit Work ed overtlae Saoke r 15*12*19 07 09.11.19 13.05.20 19.117,21 1947 1971 51 24 23 I0.04.7J 1946 1972 53 26 25 24.17.72 1973 1974 12.U6.73 114.09.74 Reactor cleaner Hal utenance, I 1lwrfftht Uu rkeJ overtlae Sucker Reactor c leaner Hactilne ehop operator and poly unit Walked overtime Saoke r React or cleaner Maintenance aaclilne shop In pi ant 25 yral banket Furnace up. pipefitter aalntenance Worked 6vrtlae Sack ct * Fd|>er by Ur K Utl.iJKKt In Anna leu ri* Annina I e pat li-j I ng ] *jne Harln, 14/M Vo I 2 1 No 2 pp!05-|14 claims title cane had both a hepatona and Ail. a 1 aul I aneona I y. FaRe CANADA Sheet 2 COUNTRY AND REFERENCE Nil NAME OR INITIALS DATE OF ftERTH 16.05.JS 20.09. 14 Cl CHEMICALS i. POLYMERS LEVER Angloaarcoaa Caaea - (Review Date: I Jan 1966} PAY - HOUTM - YEAR All date* uie UK ay*tea UPX/ASL - LANCiU<:A:jtS,6 n JS FIRST VC EXPOSURE DATE OF DIAGNOSES ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSES YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONf(RHATEON ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER S-OH KENTS mi 19H Shawlnlgsn Shawlnlgan Har 62 Yew Har 82 React or c)eaner Furnace op. aal nte nance t packaging letter (roa Dr Feruand be loraet Pat hologlac Letter I roa Dr fernand Deloiae, Pathologist SSI LOO ssy 9311-00 SSH Fage CZECHOSLOVAKIA 1C] CNKHICALS A POLYMERS LIVER Angiosarcoma Cases - (Review Dale; l Jan 8ft) WPX/ASL - LANGIOCaSEkV 12 13 COUNTRY AND REFERENCE NO HAKE OR INITIALS DATE Of aim COMPANY FIRST VC exposure DATE OF DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL J | OCOJ FAT ION I | OTHER CAREER HIGHLIGHTS CZECHOSLDVAX IA HI 1 1 | 1 | 1 1 i 1 i 02 ii ii ii 128.06.2ft | ii 11 11 11 -J1 State i i t 1 Co | l J 1 1 J Novaky 11 (1 i1 11 1 01 07.S? | il 1J 11 1t J___ --------------1 1 1 1 l 74.I2.7J ( 1 \ 1 1 J__ 45 \ 1 1 I ( \ 1 1 1 1 16 06*07*27 State Co Movaky 0J n.so U 1 I1 1 il 1 Ii i l1 1 16 124. 12.73 | 1 11 1 li 1 1I 1 11 ! 1 1 Yea i t 1 1 | 1 1 1 1 1- i i i (Autoclave ICleaner 1 1 l 1 ! Autoclev Cleaner 1 JAJtC tetter | |of 1-4-82 | (giving decal 1a | |fro* Prof | |A David of ( (Centre Ind ( (Hygiene and | |0cc dlaeaaea. ( _ji * |I ARC letter of 11-4-82 gave Jaoaetthat faltered dates |for this caae, 11 have (accepted the Ichangea since |the datea cone |fro* Prof |A David of the (Centra of JIndustrial (Hygiene and (Occupat tonal lOlaeaaea. My (datea coae forigloalty l(ro KIGSH. J_________________ OTHER COMMENTS Page 1 t-UANCt Sheet I 1C1 CHEMICALS 6 POLYMERS LlVE.it Angioaarcoaa Cases - (Review Date: J Jan 68) UVX/ASL - LANOJOCAbfcS,10 1 11 1 * (2 1 11 4 I1 ii l 1 *1 l1 J 6 i i i a 1 9 1 10 1 1 1 12 1 n 1 16 1 11 1 16 J J1 1 ii 1 1j |J 1 COUNTRY AND | REFERENCE | NO 1 1 MAKE OR | INITIALS | 1 1 DATE OF 1 IIRTH l 1 COMPANY 1 l | FACTORY i 111 11 1 FIRST VC 1 DATE OF t ACE AT J YEARS OF YEARS OF J DATE OP HISTOLOGICAL 1 ESTIMATED J I EXPOSURE | DIAGNOSIS J DIACNOS S | EXPOSURE TO i EXPOSURE | DEATH CONFIRMATION EXPOSURE J OCCUPATION 1 ii 1 DIAGNOSIS 1 t LEVEL 1 | OTHER CAREER HIGHLIGHTS 1 | | l OTHER COMMENTS J J _L i ii 11 1i i t FRANCE 1 1 1i i i | 1 J 1 \i \i i1 t i 1 ( 1 01 | H j IS.04.24 RP IRouaa- 00.01.46 | IB.02.67 | 61 1 21 19 |I9.02.6J Yea High 1 |Autoclave 1 |Ret. Ravier at 1 i1 11 | lllon i iii iiJ 1i i1 Ivorker and (cleaner |a1 At ch. Ha 1, (Prof. 1 10 n' \ i1 1 ii1 i1 |I9 yri (1 Nov n \i 1 ii i i1 1 (p 471-177 Jj JX i i i i1 11 1 0? I SIK 1I |03.06.U 1 PCUK 1 (Brlgnoud 11 06.07.S9 \ i6.ni.Ji i 61 1 1 16 i Ji i J 2 |24.Ill, 7S i Yea High 1 |2 yra on (11al1 an f | Ref . 11 1 iii i (HIOSH no laoitoaer lorIgln |C Bonne tun ei l1 i iii i 1 i coaaent) |10 yra on |al "Nouvella 11 1 iii 1i |pojymei- Ipreuae 11 1 iii i 1i llaatlon (aedlcalc" i 11 i1 i i t i J |5 Nov 1977 1 11 i1 i i i i ii ii J 9 ?15 J 1 01 l NAV J( J 106.01.20 RF j___________ JL ! 1i 1 1 I |Sl fone 1 00.00.46 1 Ji.OI.7i | 5i I 29 i ii i 1i i 29 (29.06.71 i Yea ii 1 High 11 |Polywurker (VCM product|u n(Kef. Kety et 1i 11 i i I i ii i 10 yra |16 yra |a 1 Aich. Mai. \ 11 11 i i 1 i ti (autoclave (Italian POU (Prut. I 17 n' 1 i1 t1 t i t i ii Icleaner |Shepherd, (6 June 77 ii i iiI 1i (Compounding (Sawyer, Mason (P HJ-iiS lt 1 1I I 1i i |J yr. 1 J 1 04 IKON i 1 1 1 1 1 1 1 Oi 1* 1 1 1 1 I J J___________ 11 1 1 I1 1 1 1 122.01.27 PCUK (Brlgnoud 1 19.10.49 | J6.OJ.76 | 49 l 26 I1 11 i i 1 i i1 i \ 1 i1 i1 i i J 1 1i i i t 11 \1 i i 1 t1 i1 1 1 1 j1 1 I29.0l.ie PCUK j___________ I JL 11 l 1 IRrlgnoud 1 IB.Ol.bl i n.oi.76 i IB 1 1 1 11 11 11 i i 1 1 11 i t 1 1 1r i i J 1 i i i t 1 1i i t l 1i i1 i 26 104.01.76 1i i1 i ii ii 1 ti 1 1t \ 1i 11 1 11 111*06.J6 1 1 1J 1 11 1 l1 1 J1 1 11 Yea Yea i1 ( 11 High |Honoaer (product Ion i (worker 1 1 1 ( i l yr. 1 |PVC 1 I i 1f1It ratlun 1 |IB yra t 1 JJ 1 11 ( 1 High |PoJ ywurker 1 1) Tlioracot omy jRef. p (.umle re 1 IM yt. |9th Feb 1976 (et al Semelne 1J 11 11 (coatal (dee hutiplcauc |ang]oaarcusa 110 sept embre |2)ScInt1 graphy11976 JJ (found ASI, - | Prev 1 mm 1 y had (I 1i j i 1 J1 11 l3)Haemorrhage | bone ( 11 11 1i 1i i i i i 1 1 t 11 1i 11 11 | f roa ASL iMRlgWt (anginal ft oaa~ (A) BO 11 1i j i 1 1 l1 f( | llepat ectoay | PI 11 Wiuwak l et 11 Ii i i 1 1 l1 11 | a 1 "La Nouve J1 e 11 1i i i I1 1i i i I J _L j___________ j. JL 1 l ( 1 Jt 1 11 _L 1 1 11 i1 1' (Prcaae Medical* 17th Ji.jy 1979 (Pag. 246S AS WOO s$a 82 woo s'sa 'K* 6 FRANCE Sheet 3 COUNTRY AND REFERENCE HO NAME OR INITIALS DATE OF BIRTH KCl CHEH1CAL* A POLYMERS LIVER Angfoaaccoata Caaea - (Review Date: 1 Jan 1966) WPX/ASL - LANCIOLAifcS,I I 12 FACTORY FUST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS or EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER | CJlHKR CAREER | COMMENTS HIGHLIGHTS 1 ____________I___________ 14.04.34 PCUK Brlgnoud 01.03.i6 16 l1.09.76 (NIUSH eaya 12.09.7b) (1958-1960) 2 yra flllrat I on 10-H yra )T)iJa aan had |AOL prior to |AS, Ann. de Irtal. pjot. poly worker I Ju ly '77 and work* Ip 645 A b. labT |AOL uaa found tin 19-71 Mvc lyra before I ASL 07 CIR 26.04.27 Si Auban 01.07.50 After death HI OSH aaye 00.07.76 J_____________ I 26 22 02.07.76 Yea High Plant fore- 1972-6 arfnln I Died of (N10SH no eut) nan In polymer aectlon In St Auban | eeptIceeal e |Salt liver isation I lee lent found |fter autopsy 01.04.34 Solvey 01.12.75 42 19 10.01.77 Moderate 6 yra packer J____________ i |Had been 6 autoclave Itunnel worker c Inr J 4 yra Iprevious!y autoclave worker x _L 06.10.14 St Fona 10.01.48 26.114.76 63 26 25.12,77 Very High 1948-1966 Leeaer Exposure 1966-1976 Polyaer- Iaatlon operator, utocleaner, uloclave Maintenance JO yra In sulphuric eeld factory, storekeeper 4 general eervlcea I Ope rated 4,76 |Cor reaovat of II uisour f roa 11Iver and |d I cd after laecond leurg t r*) lopcral J on I or |bl No Jb ruru hi a I I flat..I IPeper by | Dr Ret y el a I (In Archives de | Ha ladea | Pr of eaa I >>na I a | Vo I 40 Ho 6 |I979 pcigea '741- i. Page FRANCE SI.ee t J ici chemicals t rutYHtKs LIVER Anglosarcona Cases - (Review Date: I Jan 1988) NPX/ASL - LANGIULASES 112 1 1i 1 12 |3 i 4 15 6 11 81 t ti 9 i 10 i 11 i 12 n 1 >4 I t 15 1 16 JJi J _L i ii 11 l COUNTRY AND \ NAME oa | DATE Or 11 1 FUST VC DATE OF ACE AT YEARS OF YEARS UP | DATE OF KJSTOLOGICAL ESTIMATED ( OTHER 1 | OTHER REFERENCE | INITIALS | 81RTH NO 1 1 COMPANY | FACTORY 1 XPGSURE i DIAGNOSIS DIAGNOSIS 1 EXPOSURE TO 1 EXPOSURE | DEATH diagnosis 1 CONFIRMATION EXPOSURE | OCCUPATION | CAREER | LEVEL | HIGHLIGHTS 1 GOH HE NTS JJ J 1 11 11 11 1 1 11 11 11 1 | VP 124.05.19 rf | SC Fona 00.12.5b 10.01.76 58 21 1 21 (10.01.78 Yes High |Autoclave 110 yra In 1 (Died ut i1 i ii |cLeaner laechanlca1 {pulmonary 11 1 t 1 t lenglnaerlng leabol 1 aa 5 11 1 1 | iciduaf ry |days after i1 1 1 11946-1956 leurgc ry J 1 _L |L in.02.12 RP | SC Fona 06.01.41 I2.0S.78 66 17 11 11 l1 1 1 1i i t 1l 1 *i 1 1 11 111.II.76 1 * 1 1 1 Yea i High 1J 941-1946 | pol yne r- | laatIon Jgeneral Jpurpoae {worker 1 i 1 1 1 | \t 1 i 11 11 i i i 11 t 11 i i 11 l 1 1i 1i ii 11 1i 1 1i i t 11 ii ti 11 it ii 1 1 1 1 i1 i1 i1 i 1i i ii i ii i ii 11946-1972 t (VCH (eyntheala MHCJ E |Acet ylene} i | Foreman 1 (.gent l ld malt rtaeU i 11972 |ret1 red 1 1 1 J 1 1 1 i 1 1 1 1 J 12 i 1 1 1 1 in.oa.n i PCUK ii f 1 j j. | IrIgnoud i 09.02.49 i 00.05.79 ii 1 1i i i i 65 i i i 10 i ii i 27 121.06.74 1t i 1t i1 Yea |f i High |Honose r i (product loo 1 land polymerl |1aatIon I 1 i i 1 TT J i iia.6i.il i Solvay * ITavaux i i 11.04.6) i 26.06.i9 i 46 i u i ii 122,08.79 i Yea | i (operator 1 I |Autocleaner |2 yra aa cycl a|Clgareti 11 1 i 11 1 |2 yra, (echanlc. | smoker uru 11 11 1t 11 1I 1 1 1 i1 11 11 i |Auto- |10 yra aa 11974. Ill all 1 loperat or Jenamel1ar In (of 19U due to 1 (9 yra, laanltary ware |Oesophageal 11 11 11 1i 1 1 1 1 1J 1 (Copolyaera (Manufacture (varices. 1 {4 yra | Su t gl t a l 1 |ln(e r vent 1 mi 11 1 1 125.05.79 t1 J 1 l(r lht \1 jX |HJ (05-04-24 Chine | Si Fun* 1943 00.07,81 57 11 11 fhlnj, 1 ( Kn fine r I y l 11 KP) 1 11 1 1 16 r 16 129.U7.81 1 1 1 1 Yea 1 Very High 11941-1975 | 1975-1979 1941-1975 |Akl types u! (at iuenaru.tr and |Jobs on |work Intern!11 -|manuf art u t e ent 1 y 16 aa 1 ni e ns in e | hep at e< t nay J 1 t 1 1 1 11 1 t1 1975-1979 |In VCH ply 1 Jj j _L X XjX X | Prm'eaa _L_ 621.1-00 S'SU oewoo ssu Pa* & FRANCE Sheet* (Cl CHEMICALS 6 POLYMERS LIVER Anxlovarcoaa Ceae* - (Review Dale: I Jan (988) Up*/ASL - lAWClOLASfcb.n IS COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF RIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS AGE AT 01AGNOS(S YEANS OF YEARS OF EXPOSURE TO EXPOSURE DIAGNOSIS ' DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER H1CHLICHTS .OTHtH COMMENTS France i 1 u J DEP 1 1 I 1 1 -_J 1 16 |CIM ii 1 1i 1i I l 1 t 103.01.17 t Chloe | St Fone 1 Ohlmle l 1 (formerly 1 1 RP) 1 11 11 1 \ 113.07.22 Chloe J-- J | St Fona Chtmle (Formerly RP> 1 07.07.55 J28.09.62 i\ 1 i 11 1 11 11 J i i1 1 1J 11 _!___ 1 1 17.10,41 | 05.01.83 l 45 61 i 1i i i1 1 J 27 J 1 27 JAtlve i1 1 1 1 1J 1 1 11 1 1 i1 1 i t1 1 i 1 ___ u 1 -J_____ 1 11 1 41 1 38 103.04 63 | Ye Yea i\ i <i ii |Hlgh-20 yr lAutoclave i i ( {Moderate |cleaner | 11 yr. | ms-1962 ( 1 (autoclave | 1 loperator J 1 11962-1982 t 11 1 i\ I |Hlgh~33 yra|Polyaerlvat-J Ho derace- Ion Proceea Low - 5 yra Hen HeIntenence Worker ILeft Hepatectomy 11983 |J C Cc>iitMeot I Letter ul is io mi 1 1 1 1 1 (Ret 1 red Jan ]9T4. J C Coniaeaot Lettere of 5 10 19m and 2b 7 84. Health A Safety Agent 17 22.02.11 Chloe 17.04.48 03.04.8) 60 Chlmle (Formerly RP) 28 03.04.8) High 23 yra Autoclave Cleaner 1948-1971 Other vectors of St Facie Factory 197|1976 Retlred OI.Ql.79 J C Contvveu Letter of 5 10 198) 14.07.42 Solvay Tavaua 09.09.61 21.01.64 42 21 21.01.64 Hfgh-12 yrv Autoclave Low - 9 yre Cleaner 09.01.84 Right Hepatect(my 05.GS.8424.09.84 cheaol her d|y fur lungaetan teala : partial real mm 1 ii. 08.84 - I l </ e i 10.84 - l.i > FRANCE Sheet 5 EC] CHEHICALS 4 POLYMERS LIVES Angloaarcoaa Caaea - (Review Cate: 1 Jan 1988) WX/4SL - I.AKGIOLAbtb, 14 1} IS COUNTRY AND REFERENCE HO NAME OS INITIALS DATE OP BIRTH 15.12.3? 02.03.23 01.10.40 13.08.28 COMPANY SP FIRST VC EXPOSURE brignoud 07.04.59 BrIgnoud SEP Monducon St Auban 0) .09.58 DATE OF DIAGNOSIS 26.10.84 27.12.85 03.06.86 05.1 1.67 AGE AT DIAGNOSIS 63 45 YEARS Of EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION Ot. 1 i .85 34 22 26.12.85 27 28.U6.86 29 26 AJ Ive ESTIMATED EXPOSURE LEVEL HI Hi. High OTHER | OTHER OCCtJ PAT JON CAREER 1 HIGHLIGHTS I OOHMEKTS X |Myocardla L Autoclave | Jtnfarci 1 on operator artdf (1960.Coronary cleaner J |bypeaa 198). I | Utter fro* 1 Dr Con: aaaot |5,4.B6 Autoclave X |In other part a|Port aJ operator and|of factory J f t broa la f roa cleaner lalnee 1946 |26.04.74. The 111J neaa wn Idlagnnaed a | preamabl y Juork related |on 2u.04.74. I Leit er fro* | Or Ccmiaaaot 105.04.66 High High 1958-71) Low 1970-84 I Aut ocleaner (Maintenance 4 years (worker I I J I ) 12 years Autoclave worker. ( | | J4 years In | Control RooaJ ____________L I |Hepet I l teat JKay 84 noraal. (Hapatli. teat (Hay 86 showed |abruirod M t lea . I Le11 er Iro* | Dr be r t at | 18.07.86. J____________ | Lc t 11-1 I(ia |Dr Coniiiot, | At nr lie* 12.12.87 L8U00 ssu zziioo s'sa *'aXe lu GERMANY Sheet l COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF RUTH JU.UO.3Q 00.00.11 00.00.30 00.00.30 [CI CHEM1CAI S k POLYMERS LIVER Angloearcoaa Caaea - (Review Date: 1 Jan )90b) tfPX/ASL - LANClOCAStb, I 5 10 l) FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HICHLICHTS 01HER COMMENTS [4.10.57 25.09.JO 09.06.32 00.03.J3 19 16.04.37 26.11.74 iS .1)1.6* Yea (H[OSH) Polywocker I4.I2.JI Yea (HIOSH) Polywotker IU.L0.7] Yea (NIOSH) 25.11.74 Yea (N10SI1) | Ft 111 ng [peatIcfde 1 1 laeroaoi cann| [with VC 1 i1 11 i1 i1 i[ t1 iJ ii il 11 if pl \i 1t 11 200-500 ppa|Polyworker 41 1950 waa but high (temporary | autocleaner during 1 yr|autocleaner J for 1 yr autocleanerJ * 1l 11 11 |Reported undei |non polyatr1 laat1 on [workera In |HIOSH Hat of i ii.i.pp. [Thla of course (fa atclctly |cor reel. (However 1 (wonder [whether (Me |aan had high (eapuaurc to |VCM In hla lean filling (operatIonJ 1 1 |Cl 1nlcal Jdetdlla In (paper by ICokel et el IVIrchitwe Ar> h I A Path 1 976 13/2 p 195-203 **** GERMANY Sheet 2 14 COUNTRY AND REFERENCE NO NAME OS INITIALS DATE Of BIRTH ( If losil k I vea k Caee 06) 00,00.16 1 U6 \ i (NIOSH glveej aa Caae OS) 1 i 11 100.00 12 1 11 11 t1 L. 1 . 00.00,26 7 SCI CHEMICALS 6 POLYMERS LIVER AngJ oMtrcuaa Cdt.et - (Key Jew Date: t Jan HdB} WX/ASL " UNGIOLASFS, i b FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH 12 HISTOLOGICAL CONFIRMATION _L ESTIMATED | EXPOSURE | OCCUPATION LEVEL | __________ L I I I OTHER t OTHER CAREER | COMMENTS HIGHLIGHTS J ___________ 1___________ |Cootlraed 02.04.60 11 11 l i 1 7 t 16.12.62 1 00.00,75 i 41 ii 1 1 1 i 1 il i i i L--------------------1 j___ 1S.04.S4 J | 1 i l 1 n 21 Yea (HIOSU) i 11 i 12 I09.0J ?S | i l1 i 11 i 11 1 1! 21 (NIoSH aaya 12) 11.11.7 S Yea I | 1 1 i i |bO Q.cate I aaya J"cheat a t r y | J aboratortan | In the ITechno- I ioglca1 | Rtaearch (Department" KNIOSJI Bays laaafatant | factory |cheat at (which aay be |wrong II ranalat Lon) I | RA(hjr t ed unde i | non-poly*er| taut Jon {worker* In INlOSti Mat ot m.l.J? anJ 11*70. J don't | ch J nk (lit a J a Ja correct (cJ aaa 111 cat J on |by NIOSH. The lean aay have |been Involved lln VCM JpolyaerJ aat J on fin pilot plant |or In aaIn Iplanc. ----------- 1------------------------ LE t1 1 |PVC - Ha ihi- | | (factor# | | |Shlft Leader! | ii i iii |PVC Kami(lactore and tail work | Incl entit le leant ng JI 2 yra |( HS4-66) |Foreman Teel |Dev 8 yra |l9b7-197S) iy.(>7.Y4 |Polyworker 661 LOO S^U mtoo s'sti GERMANY Sheet 3 12 ICt CHEMICALS 6 POLYMERS LJVEH Anglocarcoea tduee - (Review Date; 1 Jan !4Hb) WPX/ASL - LANGIOCAiESJ 7 COUNTRY AND REFERENCE NO NAME OX INITIALS DATE OP 61RTH FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS 1 JO I (NJOSK glveal 11a Caee )| 1 1 I 1 i ________________ i ( N10SH give* at Caae 10) 12 00.00.14 20.02.61 16.06.76 4k IS 24.01.76 11 00.00 36 1 | 1 1 i1 1i 11 11 1J 1i Ji 00.00.29 2 i ( 2 1 i 1 1 1 1 ____L_ 11 OJ .01.61 I | 00.01.77 1 1 40 16 J 1 10 i 1 i1 i 1 i 1i J i1 11 11 11 i 1 1 1 i t i i i 1 1 11 ! i_________ _!___ ___ ____ ___L_ 10.JO.55 26.06.77 47 1l 07.03 77 1 | 11 1i Jt 1i i1 1t ii i! 26.06.77 Yea ,00.00.16 00.00,61 00.10,77 39 16 07.IQ,77 High peaks 12 yra polyworker Incl I7X auto clave cleaning Control i I yr 1 1i 1 110High peaka yra poly-j 1 Iworker Incl | 1 1172 auto- | \ Iclava | 1 (cleaning | 1i i 1i i 1i i I it High 1 yra lute clave cleaner 19 yra filter operator PVC Kanuf act uTe Autocleve worker for 6 yra itV 7a Coni lined Average exposure flrat 9 yra 150 ppa, occ 1000 pp*. Neat 1 yra av, 7 5 PM* Laae. yr av 15 ppe 1 |Average (expoaore tirai |9 5yra I u pp. Jocc 1000 pfa. ILaat yr av us pi. cuh 11 at ter oi 121.04.78 1 Pd*i; GERMANY Sheet 4 l COUNTRY AND REFERENCE NO NAME OK INITIALS DATE OK BIRTH GERMANY 13 00,UO.I A IS (NlOSH give# this as Case 13) 00.00.29 00.00.21 ici ciiehicais a polymers LIVE It Angiosarcoma Cases - (Review Date: I Jan |9tta) UPX/ASL - LANClUCAStl>,l8 I FIRST VC EX POSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS 00.00.60 OR.04.78 19.10.53 09.10.78 49 10.01.55 07.08.76 (l.e tbach inspected ASL at Feb 1975 1 aperotoay) YEARS QF EXPOSURE TO DIAGNOSIS 18 25 10 i i 12 I) T4 IS I ib YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER \ OTHER CAREER | COMMENTS HIGHLIGHTS < ___________ i___________ Not an Angloaarcoaa In hie letter of 2 L 12 81. Mr Frledel aatd ihl* was a "Plattenep 1 * t helkarxIno Der Spetaerohre** {a carcinoma of the oeaophagua) not attribut able to VCH A not recognised ae an Induac- rfal disease 25 23.10.76 J- Yea Autoclave cleaner and worker. Drier operator. Later ahlft Ieeder 07.06.76 Yea 1 ASL and l llepatoce) 1 uler J Carcinoma | 1 1 1 1 1 1 1 1 1 1 1 High |Autoclave |wurkef till 11964. (Leader end jmeeter 1 1 1 i 1 1 1 1J i \ i i i i i j i i i r 4i coiinn cMOU I I JF U best jlctier ot |30th June I960 (enplualng data I f rot I Hr H P Frledel >ot Bo Uieal |F U Beet 11et ter of |30tH June 1980 (enclosing date (f roa |K P Frledal of 1 BG tJteale |withdrawing Jthle case I 1 1 I I 1 |Angiosarcoma (conf Jrmed 109/79. Soae Idelall of chi# |4 also caret | 9 , I 3 ,, 15, 16 14 17 given in (NRW Report for 1197a f Angl overcome Icon! J rmed, Ifult detalla |of U ineaa | J nre March (19 71 g l ven 1 n |NRU Hed Inep |Rep for 1976. I DC f r ereitt Idetalia given (In "VC lAesoi'lsled | D1 ee<ue* by |l elbrtch and |Kn r# 1 el 1 er 9611.00 SSH Page 14 GERMANY Sheet 5 let CHEMICALS 6 POLYMERS LIVER Angloaarcoua (.dues - (Review Dale; l Jan IV86) WPX/ASL - LANG 1OCASE S , I 9 12 n i COUNTRY AND ) REFERENCE i NO i 11 NAME OR | DATE OF l INITIALS | BIRTH 1 i1 GERMANY 1_ i i j I 1 j i i 7 (NIUSH gives as Case 15) 100.00.37 1 15 oo. ml.11 TV 00.00.25 COMPANY ii i i FIRST VC i FACTORY i EXPOSURE ti 1 DATE OF | AGE AT 1 l years OF DIAGNOSIS | DIAGNOSIS | EXPOSURE TO i i DIAGNOSIS 1 11 YEARS Ok 1 DATE OF HISTOLOGICAL 1 ESTIMATED | J EXPOSURE | DEATH i CONFIRMATION i EXPOSURE i OCCUPATION | 1i i LEVEL | | _X X JL X ti i1 1 i ll J 1l i ti 1 11 4 l4 01.11.61 14.06.75 1 41 | 16 N 136.08.78 Yes High 1 |Auti<.iave 1 | HOOT T57TTTTV 15.10.54 ooor sr 54 2* 25 25.12.74 15 22.02,50 Yea Hetaeteelflf High Autoclave Worker Autoclave Worker OTHER CAREER HICHLICHTS No 1 J OTHER | COMMENTS 1 1 1 1 | Aog lauait oue t onfIraed. An n tj a 1 fepuct of the North Rhine Westpha|1 a Medical Inspectoral e for 1976 pages 147-17? gives foil details. Vinyl chloride disease dlagnosed 03-02-73. Oesophageal varices. Radlologtcatly confirmed aero osteolysis. Dr &e ache letter of J 3-04-82 to Or V C f Ada 00.00.15 21 oo.oo.n 14,02,61 00.04,80 65 19 19.IQ.50 Yea llseanglu Knduthelluaa of liver with Metaetaaea High Autoclave Worker Ol.OI.62 no. <w.?9 pronounced clinical liver s ynt ijjiu ) 66 n 19.06,60 Yea Haeaanglo EndotheEloaa of liver with He t as t ases High Autoclave Worker and worked In drying shop Dr Be sc he lettei of 13-04-82 to Dr U G F Ada Dr Besrhe tetter of I 1-04-K2 to Dr VI C. k Ada 00.00.31 15.in,61 38.08.50 19 06.12.61 Yes Hl*h Autoc]ave Chargehsnd. Dr Bcuthe Hetastaslug Worker aubaequeiitly letter of ASL Foreaan 13-04-K2 r u _L Ur U U AJaa Page 15 i.hKMANY .sheet 6 ]C1 CHEMICALS 4 POLYMERS LlVbK Angiosarcoma Caves ( Rev Date; J Jan J 960) UPSMSL - LANi;lUCAitS,2U 10 12 n COUNTRY AND REFERENCE NO NAME OS INITIALS DATE OF BUTH FUST VC EXPOSURE DATE OF DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTO LOGICAL CONFIRM ATION ESTIMATED EXPOSURE LEVEL OCCll PAT10N OTHER CAREER HIGHLIGHTS OTHER COMMENTS GERMANY 23 00.00.23 ms 26.01.79 32 24 29.uy.ai High CJiealat ry {*100 ppa) Worker 24 1 1 1 1 25 i i 1 1 1 26 27 20 i 1 1 1 J 1 J i 1 1 1 1 1 29 12 I00.00.2fl | 11 11 11 100.00.21 | 11 ti 11 !L 00.00.22 AA ft _L_ a _L_ 1 1969 1 I960 1951 I II.10.62 | 11 11 11 | 20.04.81 j I1 11 II JL 14.06.76 54 50 TT i 1 i) 21 22 1 12 12fl.05.61 | Yea High lAutoclave | 11 ( 100 pps) fCleaner | L1 11 I1 \ LI lJ4.0l.fll | Yea High 4 |Polyclave 1 | 11 11 IWorker and | lAutoclave | 11 |Cleaner | 1 . .1 22 22. 11.02 Nigh 11 Polymarker oo.oo.is mr 10.01,SI ss 28 Ul U.2J | J | ~1 i oi.io 60 | 11.08.05 i 61 i 25 i I1i 1 i i 1 111 1 i 1 111 r i 1 111 i i 1 l11 i i 1 111 i i 1 11i i i 1 1i1 i i 1 1t1 i i 1 1f1 i i 1 I11 i j 100-.00.22 _______L. 1 1962 i _J__ I5.02.fll 1 oo.nn.17 00.00,21 1951 07.01.8fi 10.06.05 00.00. Til 00,04.715 ^CUOO S?U 55 30 ir oTToTTST Yea i 25 125.08 05 | Yea | i 11i i 111 i 111 1 111 1 111 1 111 i 111 t 111 1 11 1 1 111 1 111 t 1 ____ u 1 15.02.64 25 25.05.fll All v High High High High Autoclave Cleaner till 1972 |Process 1 Iworker I94J-I |8* (01.10.60) 1-11.03.04 | |PVC product lion, | lagltator 1 I.re). | 1J t1 11 11 ii Cheml at ry worker Polyworker Shif t |eadvr Autorlave cleaner Poly wo rker Aitt i*c I ave cIeaoer Primary Nepal 11* r c re Looms; pro! 1 feral Ion ul ilie Inualodsl cell* with alnuaoldal ectsal*. Frieda] letter 21.t2.H6. (Prof Eder (Munich) J t etter 22.00.01. JFrledel Letter 39.04.85. \ |Prof Selmalr (Munich) |1etter 22.08.fll. IFrUdel Utter 19.04.05 1 1 Chronic bep.ttcle, .ngloa.roaI.. ilnu.oldml ecta.la. Fried.1 letter 21.12.06. Lei bach. Frlede) letter 19.04.R5 |Annual VCH screening 124.04.65: no complaint. |no abnormality detected. |I970 two-thf rda (gastrectomy for ulcers. IL97L Coronary tltrumbosla |1901 Femoral |Implant at ton |I904 Pulmonary tMilml Ue land ptenropneuaonla. |Lenders letters 10,09.05 land 04,02.87. 1 Haemaagtoaarkoms, Krledel Letter 21.U.06. HaeaengloserRom*. Frledel letter 21.J2.06, Haemangloearkoma. Frledel letter 21.1 2.06. HaemangJoaark one. Frledel letter 2T,t 2.0b, scuoo ssa fa**? ITALY Sheet l 16 IC[ CHfcHlCALS A POJ.YHEKS LIVER Angloaarcoea Cases - (Review Date: 1 Jen 1988) wfx/asl - LAHGJtJ CASES,21 1 1I 11 1 1 COUNTRY AND | NAME OR J DATE Of REFERENCE t INITIALS | II STM NO 1 ITALY J i 04 {On N10SH Miippl eaentary list) 02 01 04 |LC t i 1 1 t 1 J k tse t J 1 (VC 1 1 1 1 J 1 |f R 1 1 1 1 i i 1 1 1 1 115.06.14 111.11.19 | 14 ,01.20 |20.07.37 4 11 i 6i i i8 i 11 9 i LO I n \ 12 r 11 1 K ( 15 1 16 COMPANY J i i 11 i Ik i FIRST VC DATE OF AGE AT YEARS OF YEARS OF | DATE Of | HISTOLOGICAL | FACTORY EXPOSURE DIAGNOSIS DIAGNOSIS EXPOSURE TO EXPOSURE | DEATH | CONFIRMATION i i DIAGNOSIS 1l p * ESTIMATED I | EXPOSURE | OCCUPATION | LEVEL i ( OTHER CAREER HIGHLIGHTS | ( OTHER COMMENTS i _L _L i X J1 1 (i it i PANSAC (Ml re (Venice 00.00.65 19,04.71 i 16 Ob 1 t 01 116.04.71 1 TYes 11 1 |PVC leg (eat ruder (Prlaary tiaout |eay have been i i i 11 1i i1 1 i i (per 1 car dim. (Not hoaoIgeneoua with I1 i (other caaea. i (1 1 | a* ji _L ii Montedison t Porto i 00.00.57 11,12.72 i 43 (Merghere iii 15 Jr 1 1i 1 06 127,12.72 \ 1\ Yea I 1 |Polyworker i ia 1 114 i ii i Solway (Ferrara i 00.01.53 10.07.75 55 22 1i t 11 t 21 110.07.75 1 Yea High i i |Autocleener | 1972-5 did ii 1 11 |8 yra (1953- \ a variety oJ tt | b J} Autoctev a Job* J ** 1 11 (operator | Including i ii III yii (1961 - PVC packing. AttIC ji ! i _L ii (Revenue t 00.04.59 00.01.61 i 41 2k _L 21 i _i. 11 110.03.81 1 Yea i U yra - |73> 1 11 yr - 1 (Never cleaned 1 l 1i Very High IHoQoaer |autoclavea. I I 1l t 1 1 i1 ii l 1i i1 l 1i 5 yra Medina (operator 1 |20 yra (Autoclave (See paper by |CHI AFP I NO at |at Hed Lavoro IVol 6 (1982) 1 *k | Not) -auuker. [Conauaed I 1 Ut le il fl t l 1i 1 l 11 4 yra - (operator 4 |pp 555-561 Low lother dutleaj )a 1 coho r No | AGL. I 1 k1 |ln auepene- i 1 i1 |lon polyaer- 1 1 11 Illation. 1 11 11 J I 05 |G Danes(n | 19.03.37 PAHSAC (Ml ra f 00.00.67 07.03.03 1 |Venlce 1 1 1 1 1 J 1 _L I 4b l kb -1 1 11 11 11 11 11 6 (06.04.81 I Yea 1l 1\ 11 11 tt i 1 (Medina-? (High |Area Foreaai |ln iue Dept (alnce 1975. 1i r (leg extruder 11967-1975 (Cotuerclal |0ept 197b(1983 1 |S Pag lie(Lung* telex uf |2 Aug 198] Sue HaltunJ Hetl d I Lavuro 4)5 p445, |9?4. further detail it fm Or Mimtesanu ut (ARC oil April 1st Al s>n ait- ftiUnnf and Kondlnella In Ai'ta ltiicnl<i|(U'ii Vnl 1 I9HIJ ud^i 15 - 4V. Page l I ITALY Shret 2 1C) CHEMICALS k POLYMERS LIVER Angloeanood Cane a - (Review Date: l Jett 1988) WPX/ASL - i ANi, INCASES , COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OP RUTH FIRST VC EXPOSURE TEARS OF DATE OF AGE AT EXPOSURE TEARS OF DIAGNOSIS DIAGNOSIS TO EXPOSURE DIAGNOSIS DATE OF DEATH HISTOLOGICAL ESTIMATED CONFIRMATION EXPOSURE OCCUPATION LEVEL OTHER CAREER HIGHLIGHTS OTHER COHHENfS ITALY 21,06.16 Montedison Porto 01.10.60 Ha rghere, Venice I i.02.86 High i960-7I Medina 1971-74 Low 197i-a5 PVC aanulactuce 11 years ee Autocleve cleaner 1960-71. 14 year* In Cont roi ftooa 197l-8i x lettere Iron Or Chlozzlhl, 22.09,67 end 11.01.88 6^U00 SSy otrU-00 s'su age IAPAN 18 LCl CHEHU.AIS & PtJl.YKEKS LIVER Angloaarcoaa Cascb - (Review Date: l Jan 1VU8) WPX/ASL - LANG lUCAStS , i 3 COUNTRY AND REFERENCE NO 02 01 1 | J 1 NAME Oft I INITIALS | 3 DATE OF BIRTH ( Toao)l Hurl J 1 l 1 10 1.08,22 1 1 1 1 1 1 1 l 1 1 J 1 (02.08.39 i i 1 i j 1 (01.09,30 i i 1 i j l 4 (316 C0HPANY 1 1 1 | FIRST VC | FACTORY | EXPOSURE l J 1 l HI caul Teathu 1 |Nagoya 1 | 00.04.33 1 1 1 1 1 1 1 1 i ______ 1 KanegafuchllOsaka I 00,11.38 Chealcal i 1 i i HItaul Toatau j i 1 N.fOjf. 1 | 00.07.63 1 1 1 J_______ 7 DATE OF DIAGNOSIS 4 AGE AT DIACN0SIS 9 k io 1 1 * 1 YEARS OF 1 YEARS OF | DATE OF EXPOSURE TO | EXPOSURE | DEATH DIAGNOSIS a 24.10,73 * 33 a 22 1 7 |24 . 10.75 10.08.76 37 17 ii i _L t1 26.06.83 i 34 10 11 i i1 il _L t 1 13 |10.08.76 1 3 |14.09.45 i1 12 t n 1 14 Il 11 HISTOLOGICAL | ESTIMATED 1 CONFIRMATION | EXPOSURE | OCCUPAriUN | LEVEL 1 11 1 1 1 Yes | PVC A*sot 11 3 y t * mill)- |eaye not (clave 1 known. |cleaner |* Japan |1964 - tTlaea (assigned to 11ndlcsted |dIf ferent |on 25.10.7 5| wotk alnce (exposure* |had 111 (often at |hea l th (3000 ppa up| (to 1974 1 1 1 Yea |Not known |In polyner- i 11 aat Ion work ( | 11 ncludIng | (autoclave i |cleaning i1 l1 Yea 1 High |i years 1 (Autoclave J (cleaner 11 i j_________ j 1 13 ( 1 16 OTHER CAREER HIGHLIGHTS 1 | k 1 onitn I.OUHENTS 1 | Iwpdii liaca |23.10.75 t | Japanese PVC |A*Bor letter* (of 3 1.03,70 k (30,11.87 t i | 1 1 1 |J*pstieNe PVC | A**ocl at Ion | let Cera of 131.03.78 4 130.It.87 1 I leiitr 1roa |Dr NakdAura, iJspaneae PVC |Aaeoclat Ion 130.11.87 J____________ * In hie letter of let April 1942, Dr Honteaano of [ARC aaya Japanese Ministry of Labour give Date of diagnosis - 21-08-74 Age of diagnosis - 32 Years of exposure - 22 Pa*e 19 NORWAY COUNTRY AND REFERENCE NO NAME OK INITIALS DATE. Of BIRTH 1CI CHEMICALS 4 POLYMERS LIVER Angloaa fcou Caeea (Review Date; I Jan 19HH) WPX/ASL - LANCIOCASKS,?* to 12 n FIRST VC EXPOSURE DATE Of DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS Norak Hyd ro Heroya 00.03.30 21.12.71 22 HXgJi Foreman A Autoclave supervisor | | | t 1 1 1 1 1 \ \ l 1 1 1 |Cunt trued by |Dr ThlUlEvaneen of NH. |At APHE HtS at 19 June 1976 JMf P fUftfnea Istated that AU (had been a (member of a letart^up team. 1VCH 4 PVC were |made In same IbuiUlr*. Tht |VCH was made |from acetylene IPllOO SSy &1100 Page SWEDEN 20 1C] CHLHI CALS 6 POLYMERS LIVLK Angloeatcoaa Casea - (Review Dale: \ Jan 1988) WPX/ASL - LANG LUCASES,2 b COUNTRY AND REFERENCE NU 03 NAME OS INITIALS DATE OF mm 27.1 l.ll 10.08.10 Keaanord 16.t L. LA FUST VC EXPOSURE 14.08.51 Sundavall 00.01.4b Sondevall 00.0b.A7 00.00.46 DATE OF DIAGNOSIS 20.10.70 DO.08.72 18.01.76 I 2 .Ob. 7 7 ACE AT DIAGNOSIS 6b YEARS OF EXPOSURE TO DIAGNOSIS 19 29 11 YEARS OF EXPOSURE DATE OF DEATH 20.10.?G lb.08.72 21 19.03.76 11 12.Ob.77 HISTOLOGICAL CONFIRMATION 11 X I ESTIMATED | EXPOSURE | OCCUPATION LEVEL | _________ L I I I |Polyworker High X t JVCH |product ion ( I I l High X 1 I Polyworker J_______________ lb X I OTHER | OTHER CAREER | COMMENTS HIGHLIGHTS | ____________I___________ I |Hr SJuelIn*# (letter of |28 March 1976 Iconflraa BL |vae a Ronoaer (worker who wae (heavI1y leipoaed, Iprobably even Jaore ao than |a noraal | reactor |cleaner J____________ I X High |1946-1958 tpolyaer(laation Iworker (12 lyre) 6 195B|1977 fureaan 109 yra) I I J I I In M tel 12 (yra of leaployaeut had |been heavl]y leipoued. In 11974, liver |abnoraal1ty land necroal* Jd1agnoaed. (Data confIraed 11n Dr 0 Byran | let let 18.8.77 |to CEMC 1 Ob l 1 ( 1 i 1 1 1 11 I 1 1 12.01 19 | Reaanord (Simdsval || 11,OS.64 | 22.il.HO 1 61 I 16 J1 11 1 ( 1 11 ii 1 l 1 1 t1 J J 1 11 11 i 1 1 1t 11 1 1 t 1 __i _JL 1 1 ( 1 I 16 1 1 1 1 1 L- 1( (22.11 81) | 11 1 1 1l 11 11 Yea 1 | Nigh | 6 Year* I Low * | 10 Year# 1 1 1 l J1964-J 970 | cent r 1 foge loperator |1970-198U (drier loperator ( 1 | | | 1 | | 1 1 | Let ter of 12nd Nov mi 1 f rua I Or David Byren i ___________ i__________________ In tile letter of let April 1982, Dr Hcmieeanu of IAKC aaya hi Sweden'* Natlon.il Hoard uf OS Health gives 20-02-70 * date ut ittdKuoilH fur Caae tit and ib-Db-72 fur Ca*e 0/ Page 21 ICl CHEMICALS 6 POLYMERS - iUPX/ASL LANG IUC ASLS, 6 UK Sheetl LIVER Angloearcoaa Caaee - (Review bate; l Jan I'iijti) 1 1z l I *1 lI i 4 l5i 6 t 1 l ft I 9 1 1i 1 10 1 H 1 12 i n 1 u 1 15 1 16 1l JL t 1 1 l1 1 1 il COUNTRY AND | NAME OR t DATE OF ii 1 1 lt i * FUST VC DATE OF ACE AT | YEARS OF YEARS OF | DATE OF | HISTOLOGICAL | ESTIMATED 1 | OTHER 1 | OII1LK REFERENCE | INITIALS | RUTH COMPANY | FACTORY | EXPOSURE DIAGNOSIS DIAGNOSIS 1 EXPOSURE TO EXPOSURE | DEATH J CONFIRMATION 1 EXPOSURE | OCCUPATION 1 CAREER | COMMENTS NO 1 J 1 J Jl JL j DIAGNOSIS 1 1 1 1 LEVEL 1 \[ | HIGHLIGHTS i 1t i UK 1 1 ii ii t I 1\ i 1 11 1 1 01 |UJ |20.04.01 1C[ (HI 1|houne| 04.04.44 03.12.72 1 71 | 29 J 22 *Ui. 12.72 | Yea t1 1 500 pfa ) 1944-7 VCH t 11 L-c 4111J Harry 11 it <Fo t | 1 |(Ton 6 1 J 1947-8 Drier 11 an,el 11 \ ii 11 ii Collier paper aay*| 1 i ICc-Jlier | paper 1 |1948-61 \ (Autoclave |29-06074 | pages 13 16-8 iJ ii 23.11.72) | 1 Jaaye I |ope rator 1 11 11 i i i 121.12.72) 1 11961-66 J i 1i J -l i ii JL 1 t 1 1 1 1i l |Drier 1i 1 1 I i i 0? 1 1 1 1 l1 l1 tI ti 1i I1 t1 i1 il 11 1l 11 1 (UiiMmia t f at)r 1 c 11 on 11 JJ l1 JL 11 I il i1 i1 i1 l |c aae 1 1 01 |RJW 1 102.06.1? ap i Harry i | 00.02.66 00.12.74 I 37 | 09 i i 1.5 1 124.12,74 | Yea i 1 Hl**> 1 | Autoclave 1 Jt(H!h<jre 11 11 J1 1 |c leaner l J lalt e4 (d 11 JJ 11 i r 1 JL t i 1 1 1 11 1I 1 12.66 - V,69 I 1 04 I JSfi \ l I 1 123.06.20 1 1 1 i i ICI J1 |H( 1 Uiouae| 26.04.54 00.06.71 1 59 1 33 ii ii 11 I 11 i1 1 IS 112.10.79 ( ii 1 1 Yea |1 | Hedltaa- 154-5 1 high (lagging 1 IPJant 1 iii-t [Pre-war flah | packer ||4)9-4S a r.y Jvehlcle 1 1 1 1 * l1 \l l\ 11 11 l1 1 1 l1 lt 11 \ I1 i1 11 i1 11 1 11 11 I1 i i 1 1J i ii 1 it 11 11 It i \ i1 1 i1 ii 1 1 1 1 1 IDrJer Plant faalntenance l 1 IS6-58 1 liii-si 1 1 |Autoclave |flah packer 1 1 I worker 1 1 158-61 1 i (Cftargeheitd 1 i |Drier 1 1 tPtani J 1 161-72 * 1 J Foreman 1 t1 \1 11 1\ 11 11 1 1 1 1C 2/3 Plant 11 1 1 l1 l1 J\ 11 lJ 11 I1 11 1i i1 11 11 I 11 11 1 1 1 1 1 i1 I1 I1 i1 I1 1 i 1 * 1 I1 11 i1 11 \ 1 1 1 1 1i 1 1i *I 1 j____________________ f 1 l J 1 1 J______ etUOO S'SU ^uoo sy Page UK Sheet 2 22 COUNTRY AMO REFERENCE NO UK OS NAME OR INITIALS DATE OP 1IRTH 30.03.14 06 19)1 "FT RCR U.Gl.iH IP 08 ItfTM 1 i i 1 1 i i 1 1 1 1 t 1 ) 1 1 1 1 l 1 1 1 108.05.24 1 >P Ji i ii 11 11 i P1 1i 11 11 11 11 1J 11 11 11 11 11 11 11 11 11 FACTORY Mrry ferry FIRST VC EXPOSURE 08.01.51 1962 ir Id CHEMICALS 6 POLYMERS LIVER Angluaarco*4 Cubee - (Review bate: 1 Jan I9h8) 12 DATE OP 01 AC NOS 1S 00.10.79 ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS 28 YEARS OF EXPOSURE 21 DATE OF DEATH 9.M.79 HISTOLOGICAL CONFIRMATION 09.01.80 46/9 18 J 2 09.01.80 oi.oo.&o sr u 13.06.80 WPX/ASL - LANGlUCASEb.27 IT ESTIMATED EXPOSURE LEVEL OCCUPATION 1951-52 Pol yc lea lie r J952-55 Latex 1955-60 Poly f tour mo-64 Poly Qiargehand 1964-70 Charging operator 1970-72 Drier operator 1 yi. Poly Floor Operator 5 yre Creaaer on Poly FI oor Poiycleaner 1965-5 Recovery 1965-197] is OTHER CAREER HIGHLIGHTS OTHER COMMENTS l*rry 1 1 1 P 1 1 1 1 1 1 1 1 1 1 1 1 1 P 1 J 1 1 1 i4.69.io j it.ii.6i l ~vr~ il i1 l il 1 1l 1 11 1 il 1 11 1 l1 l l1 1 l1 1 i1 1 lI 1 l1 1 l1 1 t1 1 lP l l1 1 l1 1 lt 1 11 l 1J P l1 1 i n-- i 2i J25.I2 hi | i ii i ii i i1 i i1 t J1 1 11 1 if 1 11 i 11 \ 1t 1 11 1 11 1 J1 1 11 1 1P 1 11 1 11 t 1I 1 11 1 *1 1 1J 1 1 _ A______ ___ 1I950-I95ft 119S0-SI 1500 pp. |Autoclave il918-l9(,ft 1 IHotor Meehan c | 11968-1974 (operacor 1200 ppa imi-m? J1948-1950 (Operator on 1 1 i pChargeaan |Acet ytene 1 1 lautoclave |production J 1 |bulIdlng JPlanc i 11957-1974 1 1 | Shift P 1 1 1 fcauper vlm>t 1 1 1 | lut oc]av e 1 1 1 jbul Ming - 1 1 1 (Never l 1 Jr leaned 1 J 1 1 |autuclaves 1 1 1 I but 1 1 1 |aup*r vl snr 1 1 J fob entallc dp 1 P |enter! ng J 1 |autor 1 <tvi-b t 1 l 1 11 o iuvpert 1 1 lO.f* 1 1 1 1J _J _J__________________ Page U* Sheet 3 1C I CtttHICALS 6 POLYHERS LIVER Angloaercoaa Cases* - (Heview Dace: Jen 1986) UPX/ASL - LAHCIOCAStS^S JO IT JT IT it COUNTRY AND RFMNCE NO UK 09 1!1111!_______________________ 1____ | NAME OR | DATE Of i i FIRST VC i DATE OF i ACE AT YEARS OF i YEARS OF ( INITIALS | BIRTH i COW A NY ( FACTORY EXPOSURE i DIAGNOSIS i DIAGNOSIS EXPOSURE TO EXPOSURE r ii i i t DIAGNOSIS i i 1i J i | EICP 107.0S.25 l If Ibrrr (5.02.50 02.03.83 56 31 29 t1 I 11 J Ji 11 ll 1 1J (1 1 1 11 1 11 1 11 11 1 1 J J _L _J 1l 1 JO ICJT (04.Q4.47 I ftp (Retry 27.04,6t 0] 05 84 17 18 4.2 1 ( DATE or | DEATH i i 124.02.81 1 J 1 1 1 1 1 1 1 1 ) 1 | 16.05.84 11 HISTOLOGICAL CONFIRMATION Vet Ye* . ... | ESTIMATED ( EXPOSURE 1 LEVEL | | Hediua i | 1 1 1 1 t 1 I 1 \ (High - II 1 .... 1 1 1 iI 1 OCCUPATION | OTHER CAREER | OTHER | LOHHENTS i 1 HIGHLIGHTS t |Polyworke r 1 1 t 1 i |2 yeara on | i(Aery)on! t r 1 e ( (Realn Plant. 1 |A]ao prior to | 11950. 4 yeara| 1 (RAF ( 1 laalntenance. J | |3 yeara otur l i (car pain tahop | 1 |2 yeara In 1 i |Craving Duck. 1 i I_ 1 r IPolycleaner (Heavy goods | Inioraet(on 1i 1 1 laonthe (50011966-67. l v eh 1 c 1 e drlverjg Jven 1n J 1 J 1 I 1 i i j 1 It JGLP 1 i i i 1 1 1 J 1 i 1 J J 1 2 1 JT 1 J 1 l 1 1 | ii 1 1 1 ii ii it ii jX 11 (08.05.26 1 BP t 1 it 11 J1 Ii 11 J 1t J 1 1 J 1 (24.01.V ICl i i i \ t I I J ii i 1 1 1 1 ii i ii i iii i iii t i ti 1 Btry 19.12.65 t 02.06.85 i 57 i 1 1i t 1ii 1 1i 1 i1J 1 111 1 J11 J 111 1 111 J Jli 1 111 1 111 1 1JJ _J J_ _L J1 J )HIJ Jhuuee| 16,09.57 1 Ol.iib. 85 1 46 l 1 J1i 1 tJi 11 \ 1 J1i 1i 1 J1 I L9 26 ii 1 i1 i iI iJ ti ii i i! l 1 16 102.06.85 ti i1 ii i1 11 iI 11 11 IJ 11 11 t1 11 1 1 28 |0b.12.85 11 i1 11 1t 11 11 1| Yee Yew Ippa). Low- JSpray-drier (until final 118 aonthe (bagger 1967 -(111nea. IO0 ppa). J 68 * JHedlua - |Slow-down 1 i 111 aonthe latrlpper 1(200 ppa) Joperator J i 1 J1968-70. 1 1J 1 11 1 11 i 1 High J Polycleaner JI965 -69 11965-68. 1 IHed 69-79 |Service ( (Lou 79-82 Joperator 1 1 166-69. l | IPoly 1 1 |Operator 1 1 J69-79. 1 1 (Leading JUndJ 1 179-82. 1 11 1 1t 1 11 JJ f l r (Low 195?-59|Spar* man, |Hlgh 59-74 1 bagging JLow 74-65 | f1onr i i I 11957-59. i ] tAutoe lave i 1 | Oper at i>r i f 11959-85 i lltltci 110.06.84 fcoa | Or D M i JU1lllama 1 1 1 1 |Let tar of (04.06.65 (Dr Paul Satt h land letter of J04.U6.85 JDr 0 M D tvaut jOeauptidgeel |hacoorrhige (due t a loeeuplvagea) Ivarlcee due to | Anglnaarcoee (of 1t xer t 11 f 1111 126.06.85 1 Dr V 1 1 .* 1 ( 1 1 j j X Sn*0 ssy Xj j_______________ j________________ i j____________________ 9UUH) SSH Pag* 24 UK Sheet 4 COUNTRY AND REVERENCE NO NAME OR INITIALS DATE OF BIRTH UK 02*03.48 11 15.06.42 [Cl CHEMICALS 6 POLYMERS WX/ASL2 - LANGlOCASXS.b LIVEN Angloaarcoaa Caae* - (Review Date : 1 January 1988) Barry FIRST VC EXPOSURE JO TEARS OP DATE OF ACE AT EXPOSURE YEARS OF DIAGNOSIS DIAGNOSIS TO EXPOSURE DIAGNOSIS 12 n XX HISTO DATE OF LOGICAL ESTIMATED DEATH CONFIRM EXPOSURE ATION LEVEL X OCCUPATION JS OTHER CAREER H1CHMCHTS OTHER COMMENTS ma 07.0^.66 27.06.87 45 21 02.0b.b6 High |Polycleaner Low 11966-69 (Central |Depot 11969-70 High 1 Poly(loor 11970-1971 1 J (Moved to |Acrylonlt rile (Plant until lleft BP 1983. Reaatned well, working actively, until Jan I9bb |Manager of IIC 6 SS Ltd at (Cardiff Airport J1963-66 _j 10 aonthi |Polycleaner High 11966-67 J JO yeara J Poly floor constant (worker at tiaeaI Hedlua Ibetween but on 11968-1962 1nter- alttent Jobe Lettara froai Dr DKD Evan*, Pethologlat, Penarth, Wala* and Or DHJ Ullllaaa, BP, Barry Page USA Sheet I 25 ICI CHEMICALS 4 POLYMERS LIVER Angloaarcuaa Caaee - { Rev I ew Oat e : 1 Jan 1988) UK ayeieia of date* DAY - MONTH - YEAR n UPX/ASL - UNMutASLS.29 15 COUNTRY AND REFERENCE HO NAME OR INITIALS DATE OF HATH | FIRST VC FACTORY | EXPOSURE DATE OF DE AC NOS IS ACE AT DIAGNOSIS TEARS OF EXPOSURE TO DIAGNOSIS TEARS OF EXPOSURE UATt OF | HISTOLOGICAL DEATH | CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS Earl Parka 1 7.10.21 Loulavllte 09.1 2.411 uJ.m.71 I 02 19.08.11 RFC Louie- f 15.ll.il 00.05.70 37 ville | I 27.09.71 | (NJOSH | a ay a | 01 Edward 25.05.15 Dinwiddle 04 15.01.24 28.09.71M _____________ I______________ ________ L I Louis 1 28.II.45 19.12.71 t ville I 1 11 J______________ X II Louie- | OS.07.52 19.08.67 41 15 15 07.01.68 | ville I 1 1 05 Loule- | 19.06.44 09.04.64 52 20 20 vllle 1 06 Ray 23.11.28 RFC Louie- 17.01.62 00.02.74 45 12 12 24.07.75 | Auettn ville Joneel Charles T Sart S Charle-f 27.08.44 ton f i\0.00.68 21.cn.68 1 I Pot Cleaner (Stuck Jaaa 1974) p 53 Hletory given In Annala NT ACAD SCIENCES Vol 129 (1979) page 190 In Paper by B R Colt Ine ot OSHA t>l I trig Stone Art Ref t NY Acad of Sc Syap 1974 Alao block Jana 1.7.74 p 51 Pot Cleaner (Cl Block) Met I Alu block iAKA 1.7.74 p 51 Pot Cleaner (Cf Blockl Loulevflie Courier Journal 02-09-80 Pot Cleaner (Cf Block) Ref I Alau Block Kef l Alau block Pot Cleaner (Cf Block) Kef 1 Alau block US Air Force Pul Cleaner (Cf block) Re 1 I t Loulavlilr TJoea 23.7. 75 Re 11 red April 1974 Alau Hluck 06.05.20 Coodyear Niagara f ()7.10,46 l l t 41 miOO S'ffU <<r 8fcU-00 S'SU Page 26 USA Sheet 2 1CJ CHEMICALS i POLYMERS LIVER Angtoasrcoaa Ceaee - (Review Dale: 1 Jan I960) UK a yetea of detea DAY - MONTH - YEAR WX/ASL_2 - LAHLIUCASKS COUNTRY AND REFERENCE NO NAME Oft INITIALS DATE OF BIRTH nn is X FIRST VC | DATE OF | AGE AT | TEARS OF | TEARS OF | DATE OF J HISTOLOCICAL I ESTIMATED | | EXPOSURE | DIAGNOSIS | DIAGNOSIS | EXPOSURE TO | EXPOSURE | DEATH | CONFIRMATION | EXPOSURE | OCCUPATION J DIAGNOSIS III | LEVEL | | OTHER ^ OTHER CAREER | COMMENTS HIGHLIGHTS l ___________ t____________ Rayaorid GetCleFinge r? 08.11*31 Lou I *dlli 28.05,AS 1 OJ.01.74 41 29 X to IS.08.11 | Goodyear (Niagara 12.08.It \ 00.01.68 ss 17 Il- it. 01. 75 10.01.68 2000 \3im I |Hct 4 l> |wrtmg figure* |re fleet | apoeure. | l-Dlll av I lit |Tl*e 129.10.n , 112.3.75, I 10,1.7b I | Vet 27.05.09 | Goodyear (Niagara 14.10.46 | 00.01.70 21 X I 11 \J 1 i 12 |Frencla A |17.11.16 1 FIrteione I Poltatownf 11.07.49 1 02.05.69 i 50 20 IRachasn 1 1 i Pa 1 1 \ i i1 ii i i il 1t 1 i i i i1 11 1 1 i i i1 11 it ii 1i 1 1 i i1 ii I i t _j____________ 1 1 il 11 | Riche rd 101.12.21 1 UCC j_ L 1 j___ J\ i IS Char Le-| 11.12.42 00.05.74 i 52 12 Edward Clendeoln J6.01.70 i 1J i 19 102.05.69 1 1 1i i it i ii 1 ii 1 1i i ti i i\ ! i1 t 11 I 26 107.04.74 1 Tea Yes | Re f i( IHIgh 10 yra|10 yra a 1 (Utility 6 1 (reactor op. |ServLce op. 1 ((not cleaner|Bagger 1 |- separate |Dryer op. 1 (crew cleaned!Sirlpplng op. 1 laucoclavee) (1 yra prior 1| (service In 1 | |tyre plant 1 1 12000 PP" ( 1 1 1 t 1 1 (Ret | ^ letter |of 26 April 119?a tcu. |Ruaael1 A Park 11 o ) T Seawell |of NLA | 1 1 ( | Chat 1 eeton | De ft y Me 11 121.7.75 | Neve r d I ag| noaed an englloearioad of | JIver. InfureJetIon given to fleeter 22 Key | 1984 (uia IJ A ba Jg. I Ac l mint ctnl ; |AM - Ho uvlIdem v of VCH I e * [>G hu ! i. . Page 27 USA Sheet 3 XCI CHEMICALS A POLYMERS LIVER Angioearcoaa Gave a - (Review Date: 1 Jan 1988) UK Syttea of date* DAY - MONTH - YEAR WFX/ASL_2 - LAHCJ0CASES.2 COUNTRY AND REFERENCE fitl NAME OS INITIALS DATE OP HATH 12 (3 FACTORY FI AST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEAAS Of EXPOSURE TO DIAGNOSIS TEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCOJKA f ION n OTHER CAREER KJCHL1GUTS I | | | I OTHER COMMENTS 16 tJaAea IOA.IJ.27 AFC (Howard i 1j 1i 1i l !X i1 17 (Peerenbooo (06.05.31 1 AFC i i 11 i1 _j 1 IS I Chari ie I Arthur i J_ 1 122.04.28 1 AFC 1 i i 1t i1 __i 1 11 19 (Virgil 100.00.15 1 UCC I Christian 1 l Lou la(vllte 1 1 i 1 i | 03.05.50 1 ( 1 1 ( i 00.00.69 i JLoula- IvilU it i | 21.06.55 IJ.10.74 ii it (1 l !j 11 |Avon Lake| 15.09.54 00.00.75 it i1 i1 t1 i1 11 *! I1 JS Charle -I | aeon 1 00.00.43 19.06,75 1 1 1 i I i i i i i i i i i t ) t i ( i 1 i l I 1 ( 1 41 43 46 60 1 i i i i i i i i i i i i 19 19 21 32 H .08. I 7 Ccodyear Niagara Cheat er Hinkle l-nrly 11 h7 6fruoo s*a 1 04 (27.113.69 Yea 1 | 1951-4 VCM (iron 1954 liable 4 In 11 l Ipolyver- lonward* in |Wagoner (1 | (1aation |Aray and uiher 1 Teatlaany to 1l 11 it (1 | aervlce. 146-50 At ay I US Senate |Cootlraed ]n 11 *t 11 t1 ( 1 JM N Johnaon (Itr 07.00,78 |1 1 ii Tea t i 19 116.10.80 on 11.10.74 i i1 but no i t( poat-aortea i i i t i i 1 i i i 1 ! (Dr M N Johnaon (letter of 124.2.81 con- 11 16.10.80 1 1 1 |firad death ii ii t1 i 11 |02.11.75 i1 i1 it 11 ii i 1 | tt Yea J13 yra |Navy 1 1 lautocleanerJ 1 (6 yrs on J 1 |E#tol (Tyre Store 1 Iplaaticiaerj 1 (6 year* after Idlaanoa la 1 |Confirmed in |H N Johnaon |)tr 07.06.78 |A1ao Rolling |Scone nag. 11 i1 |6 Carboaat | (operation | l 1 115.01.76 t !1 1( ( 1 11 I 12 106.04.76 1i Yea (2000 pf* I 1 * 1 I UJ 11 laiaa port I1 ii t ISun Catette | 2 1 June 1975 |Charleat on (Daily Mall I 2 1.7./5 J______________ |HIUbH let tec Jut 2*>.10.7V j_______________ ____ U2.II 1.7/ (23 y t with | UCi at SC |RetIreJ iNewa telcdac 123.2.77 j___________________ OS WOO S*8U Page USA Sheet 4 28 ICt CHEMICALS 6 POLYMERS LIVER Angiosarcoma Cases - (Review Oate: 1 Jan 190H) UR system of dates DAY - HOHTH - YEAR - LANt-IUCASeS,) 12 16 COUNTRY AND REFERENCE NO NAKE OR INITIALS DATE OF SIITH COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS AO AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE OATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS USA 22 02,10.2) Lou levlll* IJ .07.47 00.01.76 52 2) TT Char laa Edwa rd Moor* oo.oo.ii I7.0S.1? Great American Chemical Company T5cc~ FItchburg 08.ot.is Him. 8 Chari** ton lf]4 06.64.}] iT.orrr To* T5" (25) a ter emit tdmlnsfcI let TT liter I960 04.12.76 tr 06.04.7] I I |Ioolav!lie |Tles 26.1,76 1 * * 1 -d he vat |the IOth AS |v1ciI* it ( Re 11 Lane ot |whoa a had Idled by |26.1.76 |Cn h( letter |of li.09.ei |0r H N Johnson Iconflraa this lla the lease deacclbed |by Dannaher jTaaburro A tea |In Feb 19*0 |Aa J Hedlclne jVol 7Q p2SQ 241 (NIOSH aya 26) 27.OS.lt Cholangtoiircoaa { R Kaat nsIt I 26/2/79) Hedlia to high for 24 yrs 1941-65 non- 1937-19 was IN M Wheeler solvent off and on JIetter of vinyl resin 1 aboil rer unit and I4]4-U f 16.8.7/ to ~|J Stafford dispersion have been IB Ivea detalJ a vinyl restna eaposed aa ftoae Kaalnahl unit first reactor |lettr of aa fitter c leaner helper, then 1943 became 126/2/79 1R Esmlnakl shift shift fitter |<6 Nov 1960) utility nun 1946 becaae lauggeeiN that shift util It |NIOSH will an Iretaln on 26.04.65 freglater tilme employment w aajthl* neoplasm terminated |*ay he aaaoct- lated with aSL. |R H Wheeler 11 e(t e r of 120/2/79 aud | Suae Xdialnakl 11 ct t l e a of p 26/2/79 and | J5/J l/hl 29 USA Sheet S JC1 CHEMICALS 6 POLYMERS LIVER Angloaarcoaa Cates - (Review Date: l Jan 1988) UK systea of dates DAY - HONTH - YEAR UYtfASL_2 - LANC10LA5ES,4 l COUNTRY AND REFERENCE NU USA HAME 01 INITIALS DATE OP BIRTH 2b John berry 07,01.2) JL Forrest J1.05.I6 28 29 "5<r _L 11.04.1? 12.10.07 22,07.22 08.11.23 tsuoo S98 b FIRST VC EXPOSURE 7 DATE OP DIAGNOSIS 8 ACE AT DIAGNOSIS 9 10 11 12 YEARS OF YEARS OF DATE OP HISTOLOGICAL EXPOSURE TO EXPOSURE DEATH CONFIRMATION DIAGNOSIS _______ _______ __________ 1 n It l ESTIMATED i EXPOSURE OCCUPATION LEVEL _L [ 1 1 i 15 OTHER CAREER HICHL1CHTS i i i i 1 i ib OTHER COMMENTS UCC UCC Tenneco Chcelcali UCC Louis ville 03.10.47 1 00.00.77 52 l (up to 2 1 (death) 1 years i I after | death) J i1 1i ii ii 1 1 J 1i t S Qm r le sion 1 01.07.4] | 10.11.78 l i 1 62 l 1 1 Ii \ S Charle ston 1_______________ i 00.08.44 | OJ.11.78 1i 61 1i S Charle 00.05.42 | 00.03.80 72 ston 1 1 _L _L_ PI eat ng ton 11.06.64 | JO.1J.80 38 ti 1l 1 1 1 11 S Charle ston 1 12.05.46 | 01.08.81 t 57 1 l 1 1 l 1 1 1 1 ( \ 1 1 1 t t 1 1 1 i i 1 t 1 i i 1 1 1 l 1 t 1 1 i 1 1 28 (death) 17 14 38 ~lT " 35 1 18 J n.02.75 1 1 i1 1 11 1 11 1 11 1 i1 t 11 ( 11 \ 1t 1 11 1 11 1 11 i I1 I 11 i !1 1 20 123.1),78 | |(NIO$H i lety* 27 1 land C I |Dally HalJ 1 i 1 1 1 125) i i 1 ii 1 it 1 11 101.11.78 | 1 11 1 11 1 16 101.03,80 | 1 11 i ii i !1 1 15 130.12.60 | 1 11 1 (1 J ii i 1I I 11 l 11 i ii i n (02.04.82 | i 11 i 1J i 11 i ii 11 i 11 i 1* i 11 i t1 i 1I i 11 i 1t i 11 i }) Yea Yea Yea Yea Yea Yea l (Exposed In (Various Juba 1 soae degree!1 a PVC 1 to 22 1 plants t rim Ichealcal* (cold rot> tu (but sain (paste (exposure (recovery (u |ws to VCH.lPVC charging | R Keol nsk 1 (1et ter of (26/2/79 and (Prof. Taaburro (latter of (9/ I/7S |probably (operator to |hi|(h (paste J Icharglng. ) 1111 August ( 11865. ( (Teralnated t (eaployaent | (Jen 1966 ) | High (Operator to (Exposure In | R N Mhee lar | (10.(0.76 (bulk and 111r of 4 Jan 11 11 (1 (dispersion PVC|I979 and (manufacture | Cha r 1 ex t on |Dally Hall it 11 ii ii (1 11 t1 11 J( ii |6 - Unknown|Maintenance |10.11.78 and |R K*aJnak 1 126/2/79 (8 Kaatnskl (letter of 16/4/79 |R Kami nekl |Lettera of (19th June I960 |1 5tti Nov 198(1 (9 - Mlntaa1(Mechanic 1 It yt* 1 (Elsewhere 1 HI yt. | |Boller houecj | (Operator 1 1* yr. [ |Hlgh (But jChealcsl (Froa 1959 to |Dr Dacey (not as hlgMOperator lu (1976 AllphaLlctletier fit reactor |charge |Cheatcala ((6,10.81 and |cleaner |react or (operator and JR N Wheeler Jwould ] (froa July l97b|lotler of (experience)| 11 u date |9 . H.fll. |Worked as | | I'oreaan |Alvo tic Dacey llabourer ( jAllphatIc (letter of (i r<ia | |Chenlral (07.Ol.ti) te (June 194 J \ |Opera!(on |da( e of death . )li> May 1848) | a Fill aay | |)uve | |4 1 8-.I III ll | 2SH.00 S9U Pag* JS A Sheet 6 30 t2 13 COUNTRY AND 1 REFERENCE | HO NAH 08 | DATE OF INITIALS | BUTH US 32 JC U Clroux 122-02-08 US 13 j |$ Perguaon 108-10-27 Jnr US 34 Hr Syria 29-01-34 ii 4 iii 6 JL II I t FUST VC COMPANY j FACTORY | EXPOSURE ii i i. 11 Honaanto Sprlngfleld 15-10-51 | Hate t i i i J i i t i t< l1 ii 11 1( ii ii ii 11 ii ii 11 JL BFG 1I J Lotilevl 1 le 09-09-54 SPG Loulevl1l 1955 1Cl CHEHICALS 6 PULYhtKS LIVER Angloaercoad Cdtea - (Review Dele: 1 Jan 1 968) UK syxtea ot dates DAY - MONTH - YEAR UPX/ASL 2 - LANCJ0CASES,5 7 DATE OF DIAGNOSIS 00-07-79 L1-05-82 03-11-82 1i 8| 9 1 10 AGE AT DIAGNOSIS 1 1 | 1 1 1 YEARS OF | EXPOSURE TO | YEARS OF EXPOSURE 1 DIAGNOSIS 1 11 11 71 ) 28 1 14 1 |(ln PVC 1 (autoclave i l.re.) i1 11 11 i1 11 11 l1 J1 it i1 i1 11 i1 11 11 1 54 f 28 1 | 28 11 DATE OF DEATH * 7-05-80 Alive i 12 In 1 14 15 11 l HISTOLOGICAL | ESTIMATED OTHER CONFIRMATION | EXPOSURE | OCCUPATION CAREER An autupay van done and luedlate cauae of death given | LEVEL Ji 1 (The death |1940-1951 Icectlflcate JVarloua Jobe Igave Jin pulyner |Mr Clroux* |aaimfacluce Juana |BUTVAR HICHLICHTS aa Joccupatlun J LUSTREX "Angloo*. .>* ' | aa "Itett le | 1951-19b4 |operator~ JVarloua Juba | In 11 n and J"cheat cal a Ja round PVC |1nduatry~. i i (autoclavea 1 1964-1973 JVarloua Yea i 1 1 1 i i i i Icletlcal IJoba In PVC tpolyner)aatIon |factllty/ |Ret 1 red 101-01-73. |Hul11 pi * ]oba 1 nc 1 ud 1 ng Poly Operator + Polycleaner, 1 1 16 1 1 J OTHER | COMMENTS i i 1 |IntoraacIon Iglven In lletter of 24 (February 1982 |C tea Dr |Walter C Iftarnea of |Honaanto | Sprlngfleld to JOr A Hunn ot (Honaanto (Europe. 1 i 1 1 1 1 i 1 IPrul Taaburro letter of J 2 Ang I 982 Or H N Johnson letter of 2ft Feb 19ft). 48 27 04. Oft.81 Poly Operator * Autocl eve Cleaner 1955-45. 1965 left BPG to becooe a Clergyman. Or H N Johnau letter of 3 Nov 1982, 2ft Feb !983 and 9 Aug 196*<. US 35 09-03-12 S Char te 21-03-44 at on 27-08-32 The General Aahtab Tire and Ula Pub her Co 18-07-83 High froa 1944 to 1955. Hedlua f ri>a 1955-1958 Moderate l95b-56 1ahuurer 1956-57 prod he 1 pf c 1957-70 operator 1970-75 elect [Ul an I 9 7 5* p r I'Mnii oin-r it -i l>t Lai ey letter of 5 Sept 1981. K W Ia.mdrfe letter of 12 Sept 19 8 3: spotle I at cd I ca 1 Hay 19ftK Tea tIng l" 0BJBC IlC L*d Hay E9ftl Page USA Slv-e-e t 7 HI CHEHICALS 6 POLYMERS LIVER Angloaarcoaa Cdaea - (Review Date: I January 1980) tbWKK/ASL2 - l.ANOJitCASKS UK ayatee uf date* DAY - MONTH - YEAR COUNTRY AHD REFERENCE NO HAKE OR 1NIT LALS DATE OF BIRTH USA Hr J Paytu Lout avtlle FIRST VC EXPOSURE YEARS OF | DATE Of ACE AT EX POSH it YEARS OF DIAGNOSIS DIAGNOSIS TO EXPOSURE DIAGNOSIS DATE OF DEATH <l6.0tj.H4 HISTO LOGICAL CONFIRM ATION I ESTIHATEDI EXPOSURE |OCCUPATION LEVEL | High L I JVJti rked Irefular ly |ln PVC arei ) In the |early daya | wait treactor (c leaner | 1953-7). OTHER CAREER HIGHLIGHTS OTHER COKHLNTS (nforndt I ori given In letter frue Dr H N Johnaon 09.08.84 26.08.22 Air Produc ta Calvert City 00*02.6) 19.01.84 39 27.06.16 Pantaaote Paaaalc I960 Kerch 1984 26.10.8) 1 High I Nome l Throabo cytopenla and leukopenia alnce alnce 1978. Cold treatment fur erthrlcla 196)-19621progreaeIon 1976. Under Dr'a care about 6 aunt lie (f roe helper before death, had paaaed etandard phyelcal I to senior eaaelnation ) eontha earlier. J ftirr lopecatoc, lettera of 22.10.84 and 2).01.03. Jcleaned (reactor#, let ripping land | recovery lareaa aa |well aa Jcharging lope ratof. IIL I JNever In hoapltel for any chronic or 24 23 29.06.84 Yea Low 129.09.60 - (Uorked I acute nedlcal probleea. Death certificate (May 66 (before (atatea cauae of death cardlo-puleonary (Vinyl 11960 larreat eecondary to angloeercoea of | Fabrlcat on|wfth US Jliver. |Plant | AC r (Letter of 13.07.86 fro* Jolm E Ertel High | Hay 66 - |Force, (of Pantaeute with letter of 24.02,86 I Aug 70 (United |froe Dr Auerbach. Pathologist. (Ut lllty |Re a In |Operat nr tilnc Jul 1 - Sep 67 |Reactor IWool |Dyera (and 66J Ok anl t e 1 1 ( I 1 1 (Uperdtor) |Sep 70-82 | Ho miner (Uperatuc 11982-81 IMtll lOper iiL nr , GSUOO SSd | (> ' 1- nct.it | S**np , nrit I | t el I ri timol frsuoo s'sa t*d(<e 3/ USA Sheet 8 \Ci CHEMICALS 4 POLYMERS LIVER Angloaarcoea Cauee - (Review Datei I January 1966) WPX/ASL2 - LANCIOCASES, UK ayatea of date* DAY - MONTH - YEAR COUNTRY AND REFERENCE NO NAME OK i DATE OF INITIALS 11KTH USA PP Cl la 26.10.14 A Ruckle, T 1915 Goodyear 10 U 14 rACTORY Loutvlllt FIRST VC EKPOSUAE 22 .OS.42 YEARS OF | DATE OF ACE AT EXPOSURE | YEARS OF DIAGNOSIS DIAGNOSIS TO { EXPOSURE OIACNOSJ S| __________ _L DATE OF DEATH 1937 72 14 01,01.8) HISTO LOGICAL CONFIRM ATION ESTIMATED) EXPOSURE 1 OCCUPATION LEVEL | L I High |Q)ea|cal 1942-|974|Worker Low I1942-45 | I 97S-19761Foreaan 11945-76 ______ !______ OTHER CAREER HIGHLIGHTS OTHER COMMENTS Letter frua Dr Diet*, BFC, 10.3.6? Niagara 7 late 1940* 1962 72 T 40* 1 30 approx f Letter from Prof Taaburro UnJveralty of Loulavllle Kj(e )1 YUGOSLAVIA U.I CUtHICM.S t. t*UL.YHt.K!> LIVEK Anglu&dreuoa Cawei> - (Review Date: I Jen 1966) Wtl ASL - LAW, I l.I.Ait S , 31 10 12 11 14 J5 lb COUNTRY AHO |tt TERENCE HO NAME OR INITIALS DATE OH BIRTH l COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIACNOS IS ACL AT DIAGNOSIS TEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTO LOGICAL CONFIRM ATION ESTIMATED EXPOSURE OCCUPATION LEVEL OTHER CAREER HIGHLIGHTS OTHER COMMENTS YUGOSLAV 1 A 1 t l1 11 01 1 1 1 105.04,I4|Jugo I IVlnll 1j -J______--i----------------- 1 t 5.I 1 *ll|Jugo iVlnll 1 1 1Spl1t 1 1 ! Split \1 I1 1 100.00 SlJOfl 04.73 | 1 i1 i1 00.00,50 12.07.73 1 J 1 59 1 1 1 _J___ 20 42 21 11 11 I1 20 106.04 73 | 11 11 -J________ 1 12.07,71 1 1 1 Yes | 1 t 1 x I 11 .Ob. 30| Jugo IVlnll J_ _ _ _ _ Spile 15.12.56 01,09,76 20 01,09.76 11 11 11 11 1J 11 1\ VCM Product Ion t 1 ISARIC el *) paper lEflv Health Perspective |pp 189-192 I9?fc Vul (7, i *tn hie letter of 3 (Jet 1978, tit splrtas of NIUSH changed the statue of Case 02 to Vl'H production eaployee, Dr Splrtse sleo notified new Case 01 alto a VCh production worker. _L Rose Kanlnskl letter of 19 Juice I960 and 1 ARC letter ot I April 1962 fiSU00 S9H "Uoo ssy Page 34 Incidence of ASL Cases Per Annum TA FILE t (Review Date - 1 Jan 1988) By date of death 1955 ............................................................................................ 1 60 7 ....................................................................................................................................................... I 8 ............................................................................................ 0 9 .................................................................................... 0 1960 ............................................ o 1 2 3 ................. 1 ............................................. 1 0 4 ................................ 2 5 ............................................................................................ 0 6 ............................................................................................ 0 7 ............................................................................................ I 8 ............................................................................................ 5 9 ............................................................................................ 3 1970 .................................. 2 1 .......................................................................... 3 2 ............................................................................................ 5 3 ............................................................................................ 8 4 ............................................................................................ 5 5 ............................................................................................ .. 6 ........................................................................................... 11 7 ............ 9 8 ............... .................................... .......................................10 95 1980 ..............................................................................................10 1 ....................................... 5 2 ............................................................................................ 3 3 ................. 10 4 ............................................................................................ 7 5 ....................................................................................................................................................... 6 6 ............................................................................................ 3 7 ......................................................................................... Total 129 H.B. I Does not include Italian 01 but does include German 03. 2 The 1977 total Includes US case 24 which is a Cholangiosarcoma. 3 Does not Include the following who are still e, so far as known: Canll Pi-1 5 & 22, 03 1 t, 3 3t ! 'j 6 Page 35 Distribution of ASL Cases by Country TABLE 2 (Review Date - ) Jan 1988) USA W Germany France UK Canada Sweden Ita ly Yugos1avla Japan Czechoslovakia Belgium Norway 38 *** 31 ** *** 22 *** 13 *** 12 *** 5 **** 5* , * kkkk 3 2 2 1 Total 138 * Omit ItOl - atypical case of PVC bag extruder. ** Includes G03 aerosol can filler. *** Includes case US 24 which was diagnosed who are still alive, so far as known. as Cholangiosarcoma; & Canll, Frl5 & 22, G3I & 32 ' UK14 ` US33 ' 36 6 41 **** Includes one monomer worker. ***** Includes two monomer workers. i .e Western Europe North America Rest of World 79 50 9 WPX/AS1.2 - LANGrnCASES.lO Tota 1 738 ZSUOO S?u SSL LOO S3H Page 36 Pattern of ASL Cases by Factory (a) W Europe TABLE 3 (Review Date - 1 Jan 1988) Of the 79 cases in W Europe, 68 have occurred In clusters at 12 factories. Of the 31 German cases, 28 have occurred In clusters at 4 factories. ASL Cases Dynamlt, Troisdorf, Germany BP, Barry, UK Wacker, Burghausen, Germany Atochem (formerly Chloe Chimie, formerly RP), St Fons, France PCUK,.; Brlgnoud, France Kemanord, Sundsvall, Sweden CWH, Marl, Germany ICI, Hlllhouse, UK Solvay, Tavaux, France Lonza, Maidshut, Germany Solvay, Jeraeppe, Belgium Atochem, St Auban, France 12 10 9 8 7 5 4 3 3 3 2 2 68 NB: There are 32 pre 1962 PVC plants in W Europe; 18 of these have had ASL cases (Ref Table 8) (b) N America Of the 50 cases In N America, 42 have occurred at four factories out of a total of 55 factories. In N America 43 plants have not had ASL cases. ASL Cases BFG, Louisville, US BFG, Shawlnlgan, Canada UCC, S Charleston, US Goodyear, Niagara Falls, US 15 12 10 5 2 NB: There are 29 pre 1962 PVC plants in N America; 12 of these have had ASL cases (Ref Tables 9 & (c) Rest of World The 9 ASL cases are believed to be in one cluster of 4 and two clusters of 2 cases. WPX/AS1.2 - LANGIOCASES , 11 Page 37 TABLE 4A Laiency Periods (Years from first Exposure to Diagnosis) (Review Date - 1 Jan 1988) W Europe N America Count ry Belgium France Ge rmany Italy Norway Sweden UK No of Cases 2 22 31 5 1 5 J_3 79 Total Years 35 574 632 99 22 122 293 1777 Average 17.5 26.09 * 20.38 * 19.8 22 24.5 22.53 * 22.49 W Europe Average Rest of World US Canada 37 955 25.81 * 10 205 20.5 * 47 1 160 24.68 N America Average Summa ry Czechoslovakia Japan Yugoslavia 2 3 4 9 30 15.0 59 19.66 85 21.2 174 19.33 Rest of World Average W Europe 79 1777 22.49 N America 47 1 160 24.68 Rest of World 9 135 174 3111 19.33 23.04 * World Average * Of the countries with below world average. jo cases, France, and USA have an average latency period above world average; Germany, UK ; NB: Does not include Canll or 12, or US41: details not known. 6SU00 S9U o9uoo s'sa Page 38 DISTRIBUTION OF LATENCY PERIODS TABLE 4B (Review Date - 1 Jan 1988) 1 1 | Belgium 1 1 1 1 Canada ** 1 1 1 Czechoslovakia | France I I | Germany 1 J Italy Japan Norway Sweden 1 I1 1 11 1 1 1 1 I UK 1 1 USA ** 1 Yugoslavia 1 1 ! TOTAL ** 1 1 1 1 t 0-9 yrs | 1 1 1 1 1 1 1 ( I 1 1 1 1 1 11 1 11 1 | 1 1 1 11 1 1 1 1 t 1 11 1 l 1 10-14 yrs j 1 1 1 1 1 31 l 1I 1 i| i 51 f 1 r i jl i 1 i 1 i jl 21 1 1 1 1 12 1 1 15-19 yrs 2 1 4 9 2 1 2 5 7 33 * Includes G 03 aerosol can filler 1 1 11 1 1 11 20-24 yrs | 25-29 yrs 1 30-34 yrs 1 35+ yrs | 1 1 11 1 1 11 I 1 11 1 1 11 1 5I 1 21 11 11 \ 11 1 11 1 31 1 81 1 31 1 31 1 10* 1 5 1 21 1 1 1 21 1 11 11 1 1 11 21 1 1 1 1 1| 11 11 i11 i 21 1 1 1 1 1 4 1 21 1 1 1 9| 81 1 51 1 6I i 1 1l 41 1 1 t t 1 11 1 37 l 1 30 1 1 13 1 1 91 1 | |1 Total 2 10 2 22 31 5 3 1 5 13 37 4 135 1 | Average | Latency 1 Period |(Table 4A) t I 17.5 1 I 20.5 1 I 15.0 1 1 26.09 1 f 20.38 1 1 19.8 1 I 19.66 1 I 22 1 I 24.5 1 | 22.53 1 I 25.81 1 l 21.2 1 1 I 23.04 1 ** Does not include Canl1 or 12, or US4 I : details not known WPX/ASL2 - LANGIOCASES,I 3 Page 39 (Review dace 1 January 1988) TABLE 4C LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE 33 MAX POSSIBLE I YEAR OF 1 LATENCY PERIOD | LATENCY PERIOD I FIRST EXPOSURE 1 (NO OF YEARS) | 1 48 I 1939 1 38* 1 1 47 1 1940 1 1 46 1 l 1 37,21,37,41 | 45 1 2 1 32,38,45 | 44 1 3 1 38,14,32 | 1 9 1 28,11,24,20,24,34,39 | 1 5 1 27,22,28,29 | 1 6 ! 21,29,31,26,28,15,23,1 1 1 30,35 40 | 7 1 29,24,29,28 I 1 39 1 8 1 28,24,34 | 1 9 t 30,26,20 | I 1950 1 26,22,31,19,23,14,33 | 1 1 1 19,28,17,28,34,29 | 35 1 2 1 21**,15 1 34 1 3 1 25,22,23,22,20,31,22,1 1 1 32*** 1 1 9 ! 21,21,25,25,21,28***,! 1 I 22 | 1 5 1 22,23,24,14,19,21,27 | 1 I 27*** 24,28,30*** | 1 6 1 21,12,27*** | 30 ) 7 1 19,17,15,13,16,28 | 29 1 8 1 18,18,15,17,20,29*** I 1 9 1 16,21,25,27 | I 1960 1 13,18,21,25,24,25 I | 1 1 15,16,16,16,19,19,12 | 25 1 2 1 13,18,17,12,18,21 1 24 1 3 1 16,17,20,21 I 1 4 1 16,17 1 1 5 1 11,19,20 | 1 6 1 9,18,21*** 20 | 7 ! 16 | I 19 1 8 1 18 | 1 9 1 13 I I 1970 1 1 11 15 1 2 1 14 1 3 1 1 ! 1 91 1 1 TOTAL 1 135 CASES | 11 1 ARITHMETIC MEAN 1 (/> OF LATENCY PERIODS 1 1 O W 289 = 36.12 8 1 1 1 o 1 1 718 = 26.59 1 27 1 1 1 1 1 521 = 24.80 1 21 1 1 1 1 1 1 787 a 22.48 1 35 1 1 1 1 1 544 m 18.75 1 29 1 1 1 1 221 > 17.0 1 13 I ! 1 31 a 15.5 2 I 1 1 VIOLA 1 1 1 MALT0NI 1 GOODRICH 3111 = 23.04 1 135 1 * Cholangiosarcoma ** Aerosol can filler *** The following are still alive, so far as known FrI5 and 22, G31 and 32, UK14, US33 and 36 NB: Does not include Canll or 12, US41: details not known WPX/ASL2 - LANGIOCASES,14 R&S 001162 cage -4U (Review dace 1 January 198?) TABLE 4D LATENCY PERIODS OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL LOCATION MAX POSSIBLE 1 YEAR OF 1 LATENCY PERIODS IN LATENCY PERIOD 1 FIRST EXPOSURE 1 WESTERN EUROPE 1 NORTH AMERICA 11 1 48 I 1939 1 1 38* 47 1 1940 1 1 46 1 1 1 37,41 1 21,37 45 1 21 1 32,38,45 44 1 3 I 38 1 14,32 1 4 1 28 1 11,24,20,24,34,39 1 5 1 27 1 22,28,29 1 6 1 21,29,31,33 1 26,28,15,23,30,35 40 I 7 1 29 1 24,29,28 39 1 8 I 28,34 1 24 1 9 t 30,26 1 20 1 1950 1 26,22,31 1 19 1 1 I 19,28,34,29, 1 17,28 35 1 2 1 21** 1 15 34 1 3 1 25,22,22,32*** 1 23,31 1 4 1 21,21,25,25 1 21,28*** 1 5 I 22,23,24,27*** 24, 281 14,19,21,27 1 | 30*** 1 6 1 21,12 1 1 27*** 30 1 7 1 19,17,15,13,28 1 29 1 8 I 18,18,29*** 1 15 1 9 I 16,21,25,27, 1 1 1960 1 13,18,21,25,25 1 24 1 1 1 15,16,16,16,19 ,19 I 12 25 1 2 1 13,18,17,18,21 1 12 24 1 1 3 1 16,17,21 4 1 16 1 20 1 17 1 5 I 11,19 1 1 6 I 9,18,21*** 1 20 1 7 1 16 1 19 1 8 1 18 1 I 9 1 13 1 1 VIOLA 1970 1 1 1 11 1 1 21 1 1 MALT0NI 3 1 1 1 TOTAL CASES 1 79 1 47 1 ROW 1 t 1 1 1 1 1 1 1 1 I 1 1 23,14 1 1 1 22,20 1 22 1 1 1 16 1 17,20 1 1 1 I 1 1 1 20 1 I 1 1 1 1 1 1 I9 * Cholangiosarcoma ** Aerosol can filler *** The following are still alive, so far as known Frl5 and 22, G31 and 32, UK14, US33 and 36 " NB: Does not include Canll or 12, or US41: details not known WPX/ASL2 - LANGIOCASES,15 TABLE 4E "age i (Review dace l January 1988) PLANT LOUISVILLE USA TROISDORF W GERMANY SHAWINIGAN CANADA S CHARLESTON USA BARRY UK 11 I START | 1 UP 1 | DATE 1 11 11 1 1940? 1 I1 1 I 1954 1 1 1 1 11 1 L943 I 1 < 1941?)| ii 1 1939? 1 1 1 | 1948 1 1 1 I 1 1 1 LATENCY PERIODS OF ASL CASES IN SPECIFIC PLANTS (10 OR MORE CASES) 12,14,15,19,19,20,24,27,28,28,28,29,29 31,45 12,13,16,16,18,19,19,21,23,25,28,29 11,12,14,21,22,23,24,24,26,28 24,30,32,32,34,35,37,38,38,39, 9,17,18,28,31,33,18,19,18,21 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 NO OF | CASES | 1 1 1 15 I 1 1 12 I 1 1 10 1 1 1 10 | 1 1 10 I 1 1 AVERAGE LATENCY PERIOD 24,53 yea 19.91 20.5 33.99 21.20 MB: Does not include cases Canl1 and 12 at Shawinigan: details not known 31 (/) o o o> CO WPX/ASL2 - LANGIOCASES,16 yage (Review dace l January 1988) TABLE 4F LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPECIFIC PLANT (10 OR MORE CASES) YEAR OF FIRST 1 LOUISVILLE) TROISDORF EXPOSURE 1 USA 1 W GERMANY 1 SHAWINIGAN 1 S CHARLESTON 1 1 CANADA 1 USA 1 BARRY UK 1939 I 1 1 1 38 1 1940 I 1 11 1 11 1 1 21 1 37 1 21 31 1 1 1 1 14 1 32,38 I 32 1 1 4 1 20 I 5 1 28,29,27 1 1 11,24 t 22 1 24,34,39 1 1 1 6I I 1 26,28 1 30,35 1 7 1 29,28 I 1 24 1 1 8 1 24 1 11 1 91 1 11 1 1950 1 19 I I1 1 31,33 11 2 1 15 1 29 1 1 1 1 I 1 28 1 3 1 31 4 1 28 1 1 21,25 1 23 1 1 1 1 1 5 1 14,19 I 23,28 1 1 1 61 1 12 1 1 1 71 ! 13 1 1 I 81 1 11 1 91 1 11 1 1960 ! 1 11 t 11 1 16,16,19,19, 1 12 1 t 2 1 12 1 18 1 1 1 18 31 41 1 1 1) 11 1 17 1 51 i 11 I 19 61 1 11 1 9,18,21 71 I 11 1 81 1 11 1 18 9 1 11 1 1970 1 1 11 1 11 1 11 1 21 1 11 1 NB: Does not include cases Canll and 12 at Shawinigan: details not known R&S 001164 WPX/ASL2 - LANGIOCASES,17 fage i3 (Review dace l January 1988) TABLE AG PLANT START-UP DATE LATENCY PERIOD OF ASL CASES NO OF IN SPECIFIC PLANTSC 4-9 CASES) CASES AVERAGE PERIOD BURGHAUSEN | W GERMANY | l1 ST FONS | FRANCE I BRIGNOUD 1 | FRANCE | |1 SUNDSVALL I SWEDEN NIAGARA I 11 | USA I SPLIT 1 | YUGOSLAVIA! I MARL I W GERMANY 1933 1939 1950 1945 1947 1950 1948 1 17,21,22,25,24,13,21,32,30 1 9 1 22.77 years 1 il 1 21,28,29,37,38,27,41,34 11 1I 1 8 1 31.88 1 I1 I 11,16,18,26,30,25,34 11 1I 1 7 | 22.85 1 I1 i1 1 1 I 16,19,27,29,31 1 5 1 24.4 1 1 1 15,17,21,23 11 t1 1 1 4 1 19 1 1 1 20,20,22,23 11 t1 1 1 4 1 21.25 1 f> I 15,16,22,21 11 11 1 4 1 18.5 NB: Does not include US41 (Niagara): details not known R &s 001165 WPX/ASL2 - LANGIOCASES,18 R&S 001166 TABLE 4H Page *+4 (Review date 1 January L988) LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPECIFIC PLANT (4-9 CASES) 1 YEAR OF iBURGHAUSENl 1 FIRST EXPOSURE 1 W GERMANY! 11 11 | 1939 1 1 I 1940 1 1 | l1 1 1 21 1 | 3I 1 1 41 1 1 51 1 1 61 | 71 1 I 1 81 1 1 91 1 I 1950 1 1 1 11 1 1 21 I | 3 125,32 I 1 4 121 1 | 5 122,24,30 I 1 61 1 | 7 1 17 1 1 81 1 1 91 I 1960 121 1 1 I 11 1 1 21 1 1 31 1 4I 1 I I 51 1 1 61 | 71 1 1 1 81 I 1 9 1 13 t 1970 1 1 1 | 11 1 1 21 1 1 1 ST FONS FRANCE 37,41 38 29 28,34 27 21 BRIGNOUDl FRANCE 1 1 1 1 1 1 1 1 1 1 1 ! 26,30 1 1 1 34 1 ! 1 1 1 1 1 18 1 16,25 1 1 1 I 1 1 11 1 1 1 1 1 1 1 1 1 SUNDSVALLl SWEDEN 1 1 1 1 1 1 1 1 1 27* 1 31 1 29 1 1 1 1 19 1 1 1 1 1 1 1 1 1 1 1 1 1 16 1 1 1 1 1 1 1 1 1 1 NIAGARA I SA 1 1 1 1 1 1 1 1 15,23 1 1 1 1 1 1 I 17 1 t I 1 21 1 1 1 1 1 1 1 1 1 1 1 I 1 1 1 1 I 1 SPLIT I marl YUGO-lw GERMANY SLAVIAI 1 1 1 1 1 I 1 ! 1 ! 1 1 23* | 1 1 20 | 22 22* | I 1 20 | 1 1 115,16 121 ! 1 ! 1 1 1 1 1 1 1 1 *Monomer worker NB: Does not include US41 (Niagara): details not known WPX/ASL2 - LANGIOCASES,19 Page 45 TABLE 5 (Review Date - 1 Jan 1988) Annual Incidence of ASL Cases (Date of Death) by Geographical Area 1955 7 1961 2 4 7 8 9 1970 1 2 3 4 5 6 7 8 9 1980 1 2 1983 1984 1985 1986 1987 TOTAL 1i 1 Western Europe | North America 11 1 |1 1 |1 t |1 1 |1 1 |1 11 1 1 I5 11 I2 t1 I1 11 12 14 I1 11 14 13 12 16 t4 t6 13 16 13 17 12 )5 16 t4 15 io 11 12 t7 t3 15 12 15 i 13 1 1 11 1 74* ** I 46** 1 Rest of World 1 Annual Total ! i l 1 l 12 1 5 3 2 3 5 38 -5 1 11 2 ll 9 l 10 -5 - 10 -5 3 I 10 t7 1 16 13 11 9 1 129 * Includes G03 aerosol can filler hut omits It 01 hag extruder | Cumulative i 1 Total j Key Events 1 I1 12 13 14 t6 |7 1 12 1 15 1 17 | 20 t 25 1 33 I 38 1 I 1 1 1 ! 1 1 t | Viola 1 1 | Maltonl 1 Goodrich 1 49 I 60 1 69 1 79 1 84 I 94 1 99 1 102 1 112 1 119 1 125 1 128 I 129 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 1 1 1 1 1 1 1 1 t | 1 1 | | 1 1 1 1 1 1 t 1 1 1 1 1 1 ** Does not include the following who are still alive, so far as known; Canll, Frl5 and 22, G31 6. 32, UK14 , US33, 36 & 41 Ul'X/ASL? I.ANC I IH7ASK5, 20 Z9U00 S9U Page 46 (Review dace 1 January 1988) TABLE 6 ASL CASE NUMBERS BY YEAR OF DEATH AND GEOGRAPHICAL LOCATIONS (EXCLUDING It.Ol) 1 KEY I EVENTS I Viola 1Maltoni I Goodrich 1955 7 8 9 1960 1 2 3 4 5 6 7 8 9 1970 1 2 3 4 5 6 7 8 9 1980 1 2 3 4 5 6 7 Total | WESTERN EUROPE i I NORTH AMERICA 1 I REST OF WORLD| 11 1 1 Cl I 1 1 | C2 i1 i1 i1 1 US8 1 1 C3 1 1 1 US5 1 1 Cz2 11 11 1 FI 1 1 C4,C5,US4,US7,US10 1 1 1 G1 1 Swl 1 G2 I US12.US16 1 US11 ! C6.US2 1 1 1 | Nl,Sw2,UKl,It2 1 C7 1 1 G3*** 1 C8,US1,US3,US23 1 Y1 ,Y2 -,Czl | 1 G4,G5,UK3 I C9.US13 1 I F2,F3,G6,G7,G8,It3 I US6,US9,US18,US26 1 Japl I Bl,F4,F5,F6,F7 ,Sw3 1 F8,F9,G10,G11,G12,Sw4 1 F10,F11,G9,G13,G15 1 US19,US20,US22, I CIO,US21,US24* I US27.US28 1 Jap2, Y3 1 1 Y4 I I G16.G17 1 FI 2,F13,UK4,UK5,G18 1 1 1 1 I UK6, UK7,G19,Sw5,G20,G21US | US17, US29, US30.US32 1 I It4,F14,UK8,G22,G23 1 1 1 G26 1 US31.C12 1 I UK09,It5,F17,B2,G24,G25,G30| US35, US34, US38 1 I UK10, F16, F18, G27,G29 | US37.US39 1 I UK11, UK12,F19,F20,G28 1 1 Jap3 1 F21,UK13,It6 1 1 1 74*** | US40 1 46*** 1 19 11 * Cholangiosarcoma ** Aerosol can filler *** Does not include the following who are still alive, so far as known: Frl5 & 22, G3L & 32, UK14, US33, 36 & 41 Canll, R&S 001168 WPX/ASL2 - LANGIOCASES,21 Page 47 (Review dace 1 January 1988) TABLE 7 ASL CASE NUMBERS BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL LOCATION (EXCLUDING It.01) KEY I EVENTS I 1 WESTERN EUROPE 1 | NORTH AMERICA 1 1 REST OF WORLD| 1 11 1 11 1 1939 1 40 ! l lFrll,Fr16 I US24* 1 1 C3.US27 1 1 1 12 1 3 1 Frl4 1 4 1 UK1 | USl3, US29,US40 1 I C2,US19 1 I Cl,C5,US5,US7,US28, US35 | 1 5 1 Sw2 i 6 IFrl,Fr3,Sw4 1 7 1 Sw3 1 C4,US3,US9 1 I C7,C9,US8,US11,US21 ,US3 11 I C6.US22.US26 I 8 1Fr9 , Frl7 1 9 1Fr!2,Fr4 | USl I USl 2 1 1 1 50 1Fr7,N1,UK8,UK9 I US16 1Y2, Cz2 1 l ISwl,UK5,Fr20,G30 1 2 |G3** | US10, US32 1 US4 1 1 1 3 IG15,It3,G26,G31*** I CIO, US37 1Japl,Y1 ) 4 |G7,G8,UK4,G19 1 US18.US33*** | Y3 1 5 1G11 ,G16,G18, Frl5*** 1 US2,U$17,US20,US34 1 1 1G23,G28,G32*** 1 6 IFR10.G1 1 1 US36*** 1 1 1 7 |Fr8,G4,It2,G2,UK12 1 I Czl 1 8 1Fr6,B1,Fr22*** 1 US23 IJap2,Y4 1 9 |Fr2,It4,Frl9,Fr21 1 1 1 60 |G5,G13,G25,G28,It6 I US39 1 1 1G9,G10,G12,G17,G20,G22| C8 1 1 1 2 IG6,UK6,G21,B2,G29 1 3 1Frl3, UK7,Frl8 1 4 |Sw5 1 5 1Fr5,UKll 1 6 1UK3, UK10.UK14*** 1 7 1 It5 1 US6 1 US38 1 US30 1 1 1 1 1 1 1 Jap 3 1 1 1 8 IUK13 1 9 IG24 Viola | 70 1 1 11 1 ! 1 ( 1 1 11 II2| | || Maltoni 1 3 1 1 1 1 Total I 79 1 1 47**** 1 19 ! 11 * Cholangiosareoma (US24) ** Aerosol can filler (G3) *** Frl5 & 22, G3l & 32, UK14, US33 & 36 are still alive, so far as known **** Does not include Canll or 12, or US41: details not known R&S 001169 WPX/ASL2 - LANGIOCASES.22 Page 48 WPX/ASL2 - LANGIOCASES.23 (Review dace 1 January 1988) TABLE 8 WESTERN EUROPE FVC PRODUCERS - STARX-UP DATES vs ASL GASES (CMUTOC C03 & It.01) 1I 0 1 ! I4J R&s 001170 StART-yPl COUNTRY NME I COMPANY NttE 1 LOCATION I ASL CASE MJMBER | YEAR OF YEAR 1931 1933 1 I West Germany |West Germany 1 I BASF |Uacker |Ludwigshafen IBurghausen 1 I 1st Exposure 11 104,07,11,15,23,24157,54,55,53,55,69,60,531 1 1938 1 Italy 1939 |France 1 1 Mootecatini |Acna Utoone-Poulmc/ ISt Fons 125,31,32 1 103,09,10,11,14 |55 1 146,48,56,41,43, 1 IChloe/Arochan 115,16,17 1940 |United Kingdom |ICI/EVC Iftjncom (Closed 1948) 155,41,48 | I United Kingdom ICI/EVC IHillhouse 101.04,12 144.54.57 1945 1 Sweden IKananord/Nobel I Sundsvall( Stockvik) (01,02,03,04,05 151,45,47,46,64 1946 1 France IRhone-Poulenc I Roussillon 101 |46 1948 1 United Kingdom! BP Chen/ICI/EVC| Barry 103,05,06,07,08,09166,51,62,63,50,50 11 IVfest Germany ICWH/rtils IMarl 110,11,13,14 109,10,26,29 166,65,68,66 161,61,53,62 1949 IBeigiun ISolvay 1 Jeneppe 101,02 158,62 1950 I France I PCUK/Atochen IBrlgnoud 102,04,05,06,12,19159,49,65,58,49,59,51 1 I France 1 IRhone-Poulenc/ | Sc Auban 120 107,22 | 150,58 1 IHolland IChloe/Arochan 1 I Shell |Pemis, Rotterdan 1 1 1 1 Norway 1 Norsk IHeroya, Potsgrurai 101 150 1951 |Switzerland ILonza/Id/EVC iSins 1952 I Italy I Montedison |Temi 1 1 1 1 1 Italy 102,06 157,60 1953 |Austria 1 France IHalvic/Solvay I Hallein ISolvay ITavauc 1 108,13,18 1 157.63.63 1 Italy ISolvay I Ferrara 103 153 I Spain IRio Rodano lUhited Kingdom!BXL/BIP/NORSK IVfest Germany IHoechst |Hemani lAycliffe iGendorf 1 1 118 1 1 |55 1954 IVfest Germany IDynantt Iroisdorf |01,02,08,12,16,17|56,57,54,61,55,61, 1955 1956 1958 1960 1 I Spain I Spain 1 (West Germany (Italy 1 I Monsanto Iberia|Monzon ICaiqsa iSabinanigo IHispavic/Solvay|Tbrrelavega ISolvay iRheinberg |S C Ravenna/EVC|Ravenna 119,20,21,22,27,30154,61,62,61,55,51 11 11 11 11 104 |59 I West Germany I Lonza/ICI/EVC | Waldstut 106,13,28 162,60,60 1961 1 Italy IMontedison/EVC I Brindisi 1 1 1962 I Portugal 1965 |France Idres IOporto IRhone-Poulenc IMontlucon 1 121 1 159 I Italy 1 Italy IPozzl IPensac iFerrandina IMira, Venice 1 105 1 167 IVfest Germany IWacker 1966 IVfest Germany IHoechst |Cologne 1 |Knapsack(Frankfurt) 105* 1 |60 1967 1968 1969 I Prance lAtochen |Spain |Rio Rodano (Greece lEsso Pappas 1 Belgian IBadiphil |United Kingdom| Viratex/Norsk 1 Italy IRunanica/EVC iBalan I Miranda de Ebro iDiavata Salonika I Antwerp iStaveley ICagliari Sardina 1 1 1 1 1 1 1 1 1 1 1 1 Continued R&S 001171 tege 49 Table 8 - Continued hESTESfl EUROPE FVC PR001XZRS - START UP DATES vs ASL GASES (OMTITPC GQ3 & It.01) ISTAKT-UPI COUNTRY N | OCMPANY mtE I LOCATICN 1 YEAR 1 I 1970 I Italy 1 ISIR 1 I Porto Torres Sar |United Kingdom!ICI/EVC I Runcorn I 1971 I Spain I Hispavic/ Solvay | Martorell | Sweden IKananord/Norsk 1Stenungsund I United Kingdom! BP Chan I Raglan Bav ! 1972 I Finland IPekana ISvartback I Holland |DS4 IBeek Limburg I 1976 I France ISoc Art D'vinyllMazingarbe 1 l(CDF) I 1 1977 |Spain 1 Monsanto Iberia|Tarragona 1 1982 I West Germany 1 ICI/EVC | VosLapp 11 I Wilhelmshaven 1 ASL CASE NUMBER | 11 11 11 11 I1 11 I1 11 I1 11 11 11 11 YEAR OF 1st Exposure * Laboratory worker in Research Department WPX/ASL2 - LANGIOCASES.24 z i \ \ o s18ti L (Review dace 1 January 1988) TABLE 9 USA PVC PRODUCERS - START-UP DATES vs ASL CASES START-UP! COMPANY NAME YEAR I 1939? |*UCC LOCATION S Charleston 1 ASL CASE 1 YEAR OF 1 NUMBER ! 1st EXPOSURE 107,13,19,21,24, 144,42,43,46,39, 1940? 1 | Dow 1 1 *BFG Midland (made Saran copolymer) Louisville 127,28,29,31,35 141,44,42.46.44 11 !1 101,02,03,04,05, 148,55,45,52,44, 1 106,09,16,17,22, 162,45,50,55,47, 1 126.33,34.37,40 147,54,55.53.42 1946 1947 1948 I*UCC/Dow I Goodyear I Firestone/ Texas City (Partially closed 1977) 1 Niagara Falls 108,10,11,20,41 146,51,46,55,? Pottstown 112 I 49 1950 1952 1 Occidental | Uniroyal 1 1 Monsanto 1 | Dow Painesville (closed 1975) Springfield (Closed 1975 Midland (No PVC 1 1 1 132 1 since c 1975) 1 1 1 151 1 1 BFG Avon Lake 118 154 1953 I Diamond/BFG Deer Park 1 1954 I General Tire/ ** Ashtabula 136 156 I DiversiTech (Closed 1984. Reopened 1986 by Vygen) 1956 | Air Products 1 Atlantic Refining Pensacola (Pace) 1 Brooklyn(Closed late 1960s) 1 Borden Leominster (Closed 1984) | Conoco Hebronville (Closed 1975) I BFG I Great American Niagara Fitchburg 1 123 158 1 Plastics | Hooker (Closed 1983) 1 Hicksville (Closed 1980-81) | Pantasote Passaic(Closed 1984) 39 60 1957 | Atlantic Tubing Cranston (Closed 1967) I Tenneco/ Flemington NJ |30 59 I Occidental 1958 1 Keysor Century (Closed 1985) Saugus, Cal 1 1 I Air Products Calvert City(Paducah) 38 63 1 (Closed March 1982 Re-opened October 1983) 1960 1 BFG Long Beach, Cal (No PVC now. 1 Formerly shown as Watson) 1962 1963 I Borden I Tenneco/Occidental 1 Conoco/Vista | Stauffer Illiopolis Burlington NJ Aberdeen, Miss Long Beach, Cal 1 1 1 (Closed 1982) j 1965 1 Conoco/Olin Assonet, Mass (Closed by Olin 1975' I Ethyl Baton Rouge (Closed 1984) j 1966 | Diamond/Georgia 1 Gulf |Gen Tire/Pantasote Delaware City Mt Pleasant W Va 1 1 |(Closed 1982) | 1 BFG I Stauffer/Formosa Henry, 111 1 Delaware City (Sold to Formosa 1981) 1967 I Allied/Robintech/ Painesville, 0. (No PVC made by Robintech. I Georgia Pacific GP converted to polystyrene) I 1 Hooker/Occidental Burlington NJ I 1968 IFirestone/Occidental Perryville (Closed 1982) WPX/ASL2 - LANGIOCASES,25 Continued Page 51 TABLE 9 (Continued) USA PVC PRODUCERS - START-UP DATES vs ASL CASES START-UP | COMPANY NAME YEAR 1969 1 BFG ! Goodyear/BFG 1971 1 Conoco/Vista 1972 | Nat Starch 1973 | Borden 1974 I Atlantic Tubing/ I Tallyrand | Shintech 1975 I Certain-teed I Georgia Pacific/ I Georgia Gulf I Tenneco/Occidental 1979 1 Firestone/ 1 Occidental 1983 1 Formosa 1986 | Vygen ** LOCATION | ASL CASE 1 NUMBER Pedricktown NJ | Plaquemine 1 Oklahoma City | Meredosia, 111 | Springfield | Cranston RI (Closed 1982) Freeport, Tex 1 | Lake Charles 1 Plaquemine, La 1 Pasadena, Tex 1 | Addis (formerly shown as Plaquemine) I Point Comfort, Tex I Ashtabula, Ohio 1 1 YEAR OF 1 1 1st EXPOSURE I 1 1 1 I 1 1 1 1 1 1 I 1 1 1 1 1 * My databank has no information on UCC before 1946 or BFG before 1950 ** Refer to same plant at Ashtabula, bought by Vygen from DiversiTech. MB Some of the plants in this list were closed down, some have changed ownership over the years, some have changed their product. R&S 001173 WPX/ASL2 - LANGIOCASES,26 Page 52 (Review dace L January 1988) TABLE IQ CANADIAN PVC PRODUCERS - START-UP DATES vs ASL CASES |START-UP I I YEAR 1 11 1 1943 I 1(1941?) | 11 I1 1 1951 I 11 11 1 1957 | 11 11 1 1966 | 11 11 1 1979 | 11 COMPANY NAME I 1 Goodrich (Formerly Gulf) 1 I 1 1 Monsanto 1 I Goodrich 1 1 | Esso (Imperial Oil) 1 1 | 1 1 Diamond Shamrock Alb/ | BF Goodrich 1 LOCATION | ASL CASE 1 NUMBER 1 YEAR OF 1 1st EXPOSURE Shawinigan 11 101,02,03,04,05 I 44,43,41,4 5,44, 106,07,08,09,10 ,147,46,61,46,53 111 * 12 II ? 1 La Salle (Closed 1975) 1 1 11 1 Welland (? Niagara) 1 1 11 Sarnia 1 1 1 1 11 1 Fort Saskatchewan 1 1 1 11 R&S 001174 WPX/ASL2 - LANGIOCASES.27 Page 53 (Review date 1 January 1988) TABLE 11 EASTERN BLOC PVC FACTORIES - START-UP DATES vs ASL CASES START-UP | COUNTRY NAME | COMPANY NAME YEAR 1 Pre 1939 |East Germany !State Company 1941 |Russia 1 State Coraps 19 50 1 Yugoslavia IJugo Vinil 1951 1 Czechoslovakia |State Comps 1955 |East Germany I State Comps 1956 I Rumania 1957 |Poland |State Comps |State Comps I Rumania 1 State Comps 1 1958 1 Rumania 1959 1 Hungary I State Comps (State Comps 1961 I Rumania 1 State Comps 1963 I Yugoslavia 1 Ohis 1965 |Bulgaria I State Comps 1967 1 Poland I State Comps 1969 |Russia 1 State Comps 1970 1 Rumania I Russia I State Comps I State Comps 1972 1 Yugoslavia 1Vlnilplastika 1975 I Czechoslovakia I State Comps I Russia 1 State Comps 1976 I Yugoslavia 1 Hip 1977 I Rumania I State Comps I LOCATION 1 1Schopau (Vladimir et al (Split |Novaky |Bitterfeldt (Icechim lOsweicim (Dwory) ITIrnaveni ITurda IRisnov IBerente Borsod 1Borzesti ISkopie 1 Varna |Tarnow I Dlerjinsk |Rimnicu Vtlcea (Volgograd 1 Zadar |Neratovice IKalush Area 1Pancevo IRimnicu Vilcea | ASL CASE | NUMBER 1 1 101,02,03,04 101,02 1 1 1 1 1 1 1 1 1 1 I 1 1 1 1 1 1 1 I 1 YEAR OF 1 1st Exposure 1 1 153,50,54,48 157,50 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 WPX/ASL2 - LANGI0CASES.28 37 So <0 o o Nl Crj R&S 001176 Page (Review dace 1 January 198 TABLE 12 JAPANESE PVCPRODUCERS- START-UP OATES vs ASL CASES START-UP 1 COMPANY NAME YEAR 1950 1 Chisso Corp | Kanegafuchi Kag 1 Tekkosha 1951 | Mitsui ToaCsu 1952 | Mitsubishi Mon I Sumltomo Kag 1951 I Denki Kagaku 1 Nippon Zeon | Toa Gosei 1955 | Ryo-Nichi 1956 | Nippon Zeon | Nisshin Kagaku 1957 | Kureha Kasai | Shinetsu Kag 1960 | Denki Kagaku I Kanegafuchi Kag 1964 1 Chisso Corp 1966 | Tokuyama Seksui 1967 | San Arrow Kagak 1 Sumitomo Kag 1968 | Ryo-Nichi | Shinetsu Kag 1970 | Chisso Corp | Denki Kagaku | Kanegafuchi Kag | Kawasaki Yuki | Mitsui Toatsu I Nissan Kagaku | Shinetsu Kag 1971 | Tekkosha 1973 1 Asahi Glass 1974 | Toyo Soda 1975 1977 | Central Kagaku 1 Toyo Soda 1 Unknown 1 LOCATION I | Minamata | Osaka I Sakata I Nagoya | Yokkaichi | Kikumoto I Shibukawa 1 Kambara | Tckushima | Uozu | Takoaka I Takeo | Nishiki | Naoetsu 1 Ohmi | Takasago 1 Chiba | Tokuyama | Tokuyama | Chiba I Mizushima 1 Tokuyama | Mizushima 1 Goi (Chiba) | Kashima 1 Kawasaki | Sakai | Chiba I Kashima | Yokkaichi | Hayatsuki | Sakata | Yokkaishi | Kawasaki 1 Yokkaichi | Kashima | ASL CASE I NUMBER 1 | 02 1 1 01, 03 1 1 1 1 1 1 1 1 1 1 1 1 1 I 1 1 1 1 1 1 1 I 1 1 1 1 1 1 1 1 1 1 1 YEAR OF 1 1st EXPOSURE 1 1 58 1 I 53, 65 I 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 I 1 I 1 1 1 1 1 1 1 1 1 1 1 1 1 WPX/ASL2 - LANGIOCASES,29 Page 55 (Review date l January 1988) TABLE 13 SOUTH AND CENTRAL AMERICAN PVC PRODUCERS START-UP| COMPANY NAME YEAR I 1953 1 Monsanto Mexica 1954 1 Policyd 1955 ! Geon Do Brazil 1956 1 Elchlor/Solvay 1960 1 Electrochlor 1 Viplastic 1961 1 Indupa 1965 I PET Columbiana 1966 1 Carburo De Col 1967 1 Plasticos Omega 1 SOC Paramonga 1968 1 Primex 1970 1 Policasa 1 Petro Dow 1971 1 Polimeros Mex 1975 I Rico Chemicals 1976 1 Petroplas 1977 1 Indust Reslstoc 1978 1 Huls Brasil 1979 1 Polychem 1 Policyd 1 PET Camacari 1 LOCATION 1 11 | Lecheria (Mexico) 1 I Mexico City (Mexico) 1 | Sao Paulo (Brazil) 1 I Sao Caetano (Brazil) 1 ICapitan Bermudez(Argentina)| 1 Mendoz (Argentina) 1 | Cinco Saltos (Argentina) 1 | Cartagena (Colombia) 1 Medellin (Colombia) 1 I I Mexico 1 1 Paramonga (Peru) 1 I Puebla (Mexico) 1 | Managua (Nicaragua) t Conception (Chile) 1 1 | St Martin Puebla (Mexico) 1 | Guyanilla (Puerto Rico) I EL Tablazo (Venezuela) 1 1 | Tlazcala (Mexico) I Cubato (Brazil) | El Salvador 1 1 1 | Coatzacoalcos (Mexico) 1 I Camacari Bahia (Brazil) 1 ASL CASE NUMBER 1 YEAR OF 1 1st EXPOSURE 1 1 1 1 1 1 1 1 1 1 13 1 1 (0 1o 1 1 U 1 i _L --1 1 1 1 1 WPX/ASL2 - LANGIOCASES,30 Page 56 (Review date 1 January 1988) TABLE 14 AUSTRALASIAN PVC PRODUCERS START-UP DATES START-UP YEAR COMPANY NAME Mid 1950s ICI Australia 1960s B F Goodrich Late 1970s ICI Australia | LOCATION | | Botany, Sydney | | Melbourne | I Laverton | Melbourne | | ASL CASE NUMBER 1 YEAR OF 1 1st EXPOSURE 1 1 1 1 1 1 1 1 R&S 001178 WPX/ASL2 - LANGIOCASES,31 Pa^e 57 (Review dace 1 January 1988) TABLE 15 MIDDLE EASTERN PVC PRODUCERS START-UP DATES ART-UP I COUNTRY NAME DATE I I COMPANY NAME | I I LOCATION Sept 1986 | Saudi Arabia 11 11 11 | National Plastic 1 Company | (Ibn Hayan) 1 |Arabian Petrochemical IMadiant lAl-Jubail lAl-Sinahyah Company R&S 001179 WPX/ASL2 -- LANGIOCASES.32 08 WOO SSH Pa*e; Country; ICI CHEMICALS 4 POLYMER5 LIVER Anglosarcoaa Caaea (Review Date; 1 Jan 19..) 1 2 | ) f 4 i 5 I 6 t 7 ( 8 ( 9 i 10 | JL 1 iI 1 COUNTRY AND | NAME OK | DATE OF 1 REFERENCE |INITIALS) BIRTH r COMPANY 1 i J i J l J 1 (YEARS OF i 1 i 1 J FIRST VC |DATE OF (AGE AT (EXPOSURE |YEARS 0F| \ FACTORY |EXPOSURE (DIAGNOSES!DlAHQSIS(TQ | EXPOSURE! NO 11 i iiI (DIAGNOSES) j JL j_ JL j J J J1). it DATE OF DEATH 1 12 ( IJ f 14 iI f (5 | 1 IHISTO- I 11 J| I LOGICAL 1 ESTIMATED] (OTHER | 1 CONFIRM-*EXPOSURE |OCCUPATION 1 CAREER t JAT ION 1 LEVEL (KlCHLICHTSJ J________ __________JL _ UPX/ASL - LANCIOCASES, 12 16 OTHER COMMENTS W