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: am VJeaen sB. pSwaeeney S3aMltEnyviOrpoenrmaetnitoanls,Healthand 223579 5S3tM1PG7aen3,t7er3,58Bu05i5d1i4n4g-0120240-006 ba. AL2253ME Certified Mail gon 1600 & July 13,2010 EDoPcAumEaesntt--PrRoocoesmsi6n4g2C8eAntttenr: Section 8(c) OUfSfiEcePoAfPollution Prevention and Toxics W1a2s0h0iPnegninosnylDvCani2a04A6v0e-n0u0e01NW 3 No=CBU 3 2 Re: TSuSlCfoAna8t(ee-)baSsubesdtaanntdiaClarRbiosrkyNloitci-cbea:seSdupFpllueomreoncthaelmitcoalDsocket No. SEHQ-0598-373; "To whom it may concer: c3aMrbiosxsyulbamtiet-tbiansgedthfilsunoortoiccheemtiocsaulpsplement is previous submissions on sulfonate. and p3eMrfrleucoernotolcytarneecesiuvlefdonaanteab(sPtFraOcSt).froTmhea okbijneetcitciveevaolfutahtiison84i-ndmaiynsktu(dMyuswtaeslatovaisssoens)sctohneducted on mtogxkicgo/kdinaeytoicfpPrFoOfSileionftPheFiOrSdicotnfwoirld5l6ifdeayssp.ecTihesi.s wTawsenftoyllaodwueldtbmyalae2m8-idnakywreerceovaedrmyinpiesrtieorded 20 PduFrOinSgtwrheaitcehd galrloaunpimoanlsstwuedryedafyeds a2n8,u5nt6raeantded84.coFnitvreocdoinett.roFliaveniamnailmsalwserweersaecrsiafciricfeidcoend fsrtuodmythe dfoaryshi5s6tolaongdic$a4l. aAstsessascmreinfti.ce the heart, spleen, kidneys, adrenal lands and thyroid were collected sBtouddyy dweaiygsh4t2s,o4f9mainndk5f6.edWdiitcthsincosnetvaeinnidnagyPsF(sOtSudwyedraeysi6g3n)iofficbaenitlnyglfeesds cthoempuantrreedatteodccoonnttrroolls on Adibest,olbuotdeyawnedigrehltastiovfe t(h%eoPfFbOoSdyanwiemiaglhst)wesrpeleeeqnuiwveailgenhtsoofcPoFntOrSolaanniimmaallsbwoedryewsegingihftiscanly less ethxaanmicnoendt.rolOnwesitguhdtysdaatyst2u8d,yadmaaysxi6malansde8r4u.mTPhFerOeSwceornecennotrhaitsitoonlowgiacsalrecahcahnedg.esTihnisthweatsissues cfoonlsltoawnetdtbhyraougsthatsitsutdicyaldlayysi5g6.nifiDcuarnitndgrtohpei2n8c-odnacyenetlriamtiinoantiboyn spthuadsyeodfayth4e2 stthuadtyr,esmeariunmedPFOS. cHoenpcaetnitcraPtFiOonSdceocnlciennetdraatpipornosxiwmearteelaypp4r0ox%imfartoemlysehraulfmocfonrceespneicrtaitvieonsseorbusmercvonecdeontnrasttiuodnysdaanyd5d6.id dneoctrcehaasnegdebbyeatpwpereonxismtautdeyldya3ys0%2.8 and 56. During the 28-day elimination, hepatic concentrations "uTnheexpobescetrevdatbiaosneodfobnodthye-woeibghst ererducvotfiaobntodefiyf-eowcteniign shmtinrekodunctdioonsienfgfewcitsthinPoFtOheSr isspencoitesc.omSpilnecteely tmhienrkehsaulvse onfotthbiesekninperteivcieovuaslluyatuisoend ian tlhaebo8r(a)tdoroyckaenitmaaslsa isnuptphletmesetnitngtoofprPeFvOiSo.us3suMbmiisspsliaocnisn.g : P.2 yohu oen actions oe E aoe n forptniwsooFt ewntdNFCe The in-life portion of this study is complete and an abstract has been produced. It is unknown at (651) 733-9384. Gordes Sosenesy Gore) --_-- StaffVice President, Environmental, Health and Safety Operations p3 J LKinNeetwisctEeSvdta?el,puhSaJat.niioBenuSorfmsiiPteahrn-f,El|duEwo.arLoriodncskt??a,nMDe.MJS..uElAhflor-neJasatmweaan(d?P?,,FOAaS.nE)d. iDnrMoiwn?,k S(cMoutstteFliatzvgiesroanl)d?, JL. Butenhoff 1Entrix, Inc. 2Michigan State University, 23M Company. fPleurofrloucohreomoicctaalnse dseurlifovneadtfer(oPmFOpSe)r,fltuhreouolcttiamnaetesudlefgonryaldaftluioornidper,oidsuwcitdoefsspurlefaodnaitnetdhe einncvliurdoinnmgemnti.nkP(FMOuSsthealsa bveiseonn).detHeecptaetdicincwoantceern,trsaoitli,ofnissho,fbPirFdOsSainndmmianmkmcaolnss,uming hfiesphatfircomPFSOaSgicnoanwceBnatyr,atMiiownserheavaes bgereeantdaeste4.c0teudg/ign.miBnekc,auasseserseslmateinvteloyfgtrheeatits wtiolxdilciofkeisnpeetciicesi.s aTnweinmptoyratdaunlttsmtaelpeimnitnhkeweevraeluatfeidonaodfietthecoinmtpaaicntinogf2P0FOmSgoPnFOS/kg tfeheedn aanndim1a0lsmoinnkthwaetrterefaedtmaencotnwterorlediperto.viTdheed PcFonOtSrodlieftewedasfoprrtohveidreedmfaoirni5n6g d28adndof dtheete8r4m-idnatrtiiaol.n OofnPdF0O,Sblcoonocdenatnrdatliiovnesr.saImnpladedsitwieorn,e tchoellheecatretd, fsrploemenf,ivkeiadnniemyas,ls for aadsrseensaslmegnlta.ndAsllananditmhaylrsoiwderweerweeirgehmeodvewde,ekwleyigahneddbalnododprsoacmepslseesdwfeorrehicsotlolleocgtiecdal ceovnetrryoltwmoinwkeewkesr.eOsnamdp2l8e,dfaivsedPeFscOrSibmeidnkabaovned.onBodd5y6waenidghdts84o,ffmiivenkPFfOedS dainedtsfive c56o.ntWaiitnihnign P7FdOSofwbeeriengsipgrnoivfiicdaendtlcyonletsrsolcofmeepdar(ded63t)o, cboondtryowlesiognhtdso42f,PdF4O9S aanndimdals swpelreeeneqwueiivgahltesntoftoPFcoOnStraonlibmaoldsywweerigehtsisg.niAfbiscaonltultyelaesnsdtrhealnatciovnetr(o%lowfeibgohdtyswaetidgh5t6) sanedrudm8P4.FOTShecroencweenrtreatnioonhiwstaoslorgiecaaclhecdhaantgdes28i,n ftohleltoiwsesduebsyeaxsatmaitnisetdi.calAlymaximal sDiugrniinfigctanhte 2el5i%midnratoiponinpchoansceenotftrhateiosntubdyy,ds4e2ruthmatPFrOeSmacionnecdenctornasttiaonnts tdhercoluignhedd 56. caopnpcreonxtirmaattieolnys4w0er%efarpopmrocxoinmceantterlaytihaolnfsofobrseesrpveectdioven sde5r6.umHceopnacteinctrPaFtOiSons and did cnoontccehnatnragteiboenstwdeeecnredas2e8dabnydadpp5r6.oxDiumraitnegltyhe30%28.-d elimination phase, hepatic