Document M4OaDyeb4Mk4pEQmja96XXM2y

\ Reprinted from British Journal o) Industrial Medicine 1985;42:750-753 Copyright 1985 British Journal of Industrial Medicine All rights of reproduction of this reprint are reserved in all countries of the world Exposure to vinyl chloride and angiosarcoma of the liver: a report of the register of cases D FORMAN. B BENNETT, J STAFFORD, AND R DOLL British Medico! Association, Tavistock Square, London WCIH 9JR AP00055837 British Journal of Industrial Medicine 1985;42:750-753 Exposure to vinyl chloride and angiosarcoma of the liver: a report of the register of cases D FORMAN,1 B BENNETT,2 J STAFFORD,1 AND R DOLL1 From the Imperial Cancer Research Fund Epidemiology and Clinical Trials Unit,1 Radclijfe Infirmary, Oxford OX26HE. and Imperial Chemical Industries pic,2 Thornton Cleveleys, Blackpool FYS 4QD, UK abstract The Association of Plastic Manufacturers in Europe maintains a register of all cases of angiosarcoma of the liver (ASL) resulting from exposure to vinyl chloride monomer (VCM). This register has recorded all known VCM related cases of the disease worldwide that have been histologically confirmed. Although likely to be incomplete, it is the most comprehensive tabulation of such cases available and, by the end of 1984, 118 men had been registered. The information from analysis of the cases currently on the register is used to make an approximate projection of the number of cases to be expected in the future. The conclusion from this projection is that the industry is reaching the halfway stage in the appearance of VCM related ASL. The idea that vinyl chloride might cause cancer was first suggested by Viola in 1970 as a result of experi ments in rats.1 This was subsequently confirmed by Maltonr in 1973 with his comprehensive series of experiments in rats. mice, and hamsters.2 Among the tumours that developed in these animals was the nor mally rare angiosarcoma or the liver (ASL). It was not, however, until three cases of ASL were observed in men who had been heavily exposed to vinyl chloride in a polyvinyl chloride (PVC) polymerisation plant in the United States that the reality of the hazard was generally accepted.3 ASL is normally so rare that only three or four cases occur each year in the whole of Britain (see below) so that the occurrence of three cases in a small group of industrial employees in the United States was, in itself, sufficient to justify the belief that the chemical caused the disease. If, how ever, any doubt has persisted it was soon dispelled by the steady accretion of new industrial cases and the finding that angiosarcomas and various other tumours could be produced in rats by levels of exposure that were appreciably less than those that had previously occurred in industry* Steps were therefore quickly taken in the mid-1970s to reduce the extent to which individuals could be exposed from levels of the order of several hundred ppm to 5 ppm (13 x 10s ngm/mJ) or less.5 This reduction followed Received 25 February 1985 Accepted 25 March 1985 an earlier lowering of exposure levels in the mid-1960s after concern was expressed about the narcotic effects of vinyl chloride and the risk of it producing acroosteolysis. Before then exposure to some employees was often in the range of several thousand ppm. The rarity of ASL. even under conditions of heavy exposure, has made it difficult to study its epi demiological characteristics and it seemed, therefore, that it might be of value to summarise the data that have been recorded in the register of cases that has been maintained by Imperial Chemical Industries pic on behalf of the Association of Plastics Manu facturers in Europe (APME). This tabulates informa tion about all the cases of ASL known to have occurred in men exposed to vinyl chloride that have been reported by individual manufacturing compa nies, trade associations, and occupational health organisations in Europe, North America, and Japan. The register is, doubtless, incomplete. It includes. Table l Numbers of vinyl chloride related cases of angiosarcoma of the liver by date of death Period No of deaths I9S5-9 1960-4 1965-9 1970-4 1975-9 t980-4 1955-84 2 4 9 23 46 31 115" "Three men diagnosed in 1980-4 were still alive at I January 198$. 750 AP00055838 Exposure lo vinyl chloride and angiosarcoma of the liver 751 Table 2 Numbers of vinyl chloride related cases of angiosarcoma of liver by age at diagnosis Age t) earr) 35-39 40-44 45-49 50-54 55-59 60-64 65-69 70-74 All ages No of casts U 24 . 17 IS 20 17 S 3 ns however,, alt the cases known to the collaborating organisations and they will probably have been informed, in one way or another, about nearly all eases that have been diagnosed among the relevant groups of employees. Results Until the end of 1984, ! 18 men had been recorded as having vinyl chloride related ASL, of whom three were still alive on 1 January 1985. All the cases had been confirmed histologically: 117 were reported to be hepatoangiosarcomas and one a cholangiosarcoma. No cases were recorded in women, but few women have been employed in manufacturing PVC. Table I shows the breakdown of the cases by date of death. It should be noted that the register was begun in 1974 when vinyl chloride first became firmly established as a risk factor for ASL. Under-reporting is, therefore, less likely to be a problem after this date when special attention began to be paid to the disease. Table 2 gives the age distribution of the 118 men at the time of diagnosis. The mean age at diagnosis is 52. Table 2 gives the number of cases diagnosed and the number of PVC producing factories in each of the 12 countries reporting at least one case of ASL. Some countries have had cases in most of their factories (France. West Germany): others have had cases clus tered in a small number of factories {United States, United Kingdom). Indeed, the United States has had 23 of its 33 cases in just two factories. Other countries that produce PVC but have not reported any cases are shown in tabic 4. Table 5 shows the numbers of cases by time since first exposure and maximum exposure time possible. It seems that the incidence of ASL reaches a peak 20-29 years after first exposure but substantial num bers of cases may still occur after more than 30 years. The table also gives hypothetical numbers for expected new cases based on the distribution of cases in men who could have experienced the maximum latency period. These calculations show that the occurrence of vinyl chloride related ASL is not yet at the halfway stage and one might reasonably expect another 150 cases or so with an unknown number of further cases occurring 35 years or more after first exposure. Table 6 shows (he principal occupations of the 118 affected men. At least 43% of the men (51/118) had been employed as autoclave cleaners, an occupation that has been thought to have necessitated the highest exposure to vinyl chloride monomer. Discussion The reassuring feature of these results is that the num ber of eases on the register is so small, and, in partic ular, that only 80 new cases have been diagnosed since 1975, despite the large size of the industry. In the decade 1975-84, 19 cases were registered from the United States and seven from the United Kingdom. In men aged over 15 about 3300 deaths a year are attributed to all types of liver cancer in the United States and about 550 a year in the United Kingdom. Many of these cancers are probably sec- Tablc 3 Distribution of vinyl chloride related cases of angiosarcoma of liver by country. (Number offactories with three or more cases in parenthesesI Country No of eases No offactories reporting cases 7'dtfli' No offactories making PVC Pre-197* Prt-m* Capacity' in 1972 United Stain W German* France Canada United Kingdom Sued en (tab Yugoslavia Czechoslovakia iaoan Belgium Norway All countries reporting cases 35 26 IS 10 9 J 4 4 1 2 2 l IIS 10 (3) 6 (3) 5 (3) 1 (1) 2 (!) 1 (!) 4(- i in i (-) t <--> i <-) i (-) 34(H) 44 9 7 4 7 2 II 3 1 31 2 1 122 28 7 5 3 4 1 7 2 1 16 t 1 76 `Capacity in Wloionncj pvc production a year (Information supplied by ICl and by recipients of (he register). 2090 H55 627 38 502 105 778 60 48 1699 195 65 9462 / \ 752 Forman. Bennett, Stafford, and Dolt Table 4 Countries with PV'C factories operational before 1974 with no cases reported to register limes became faint and unconscious before the 1960s. when the main concern about vinyl chloride was its Country Total No o) facujries Ptt-1974 Pre-1964 narcotic effect. Secondly, in some countries there is a remarkable clustering of cases into a small number of factories. This suggests that the working conditions Western Europe Austria \l Finland 1-- Greece t-- Holland 21 Portugal i 1 Spain 4J t Switzerland Eastern Europe 1 1 Bulgaria 1 East Germany Hungary 2 1 2 1 Poland 21 54 USSR 3i South America Argentina 3 3 Brazil 12 _Chile 1-- Colombia 2 Mexico 52 Peru l-- and hygiene standards varied in different factories. Fifteen of the 16 Japanese and 19 of the 28 United States factories operating before 1964 have reported no cases, and it would be helpful if it could be shown that the exposures in these factories was appreciably less--unless, of course, the number of employees in these factories were ail very small. It is the rarity of this tumour that has enabled its rapid identification as an effect of exposure to vinyl chloride. Baxter tt a! have calculated that the back ground incidence of ASL in the United Kingdom is between two and seven cases a year--that is, cases unattributable to exposure to vinyl chloride or to tho- rotrast. the other established aetiological agent.7 That being so then the seven industrial.cases in the decade 1975-84 represent an increase in the national figures f Source; Information supplied by ICI aid by reoptenis of the register. of between 10% and 35%. The mean induction period (time from first ondary liver cancers originating in other organs, par exposure to initial diagnosis) for the 113 cases is 22-6 ticularly in men over <50, but if this is ignored it years. Most cases have occurred 15 to 29 years after appears that only about 0 06% of liver cancers in first exposure as is common with occupationally adult men in the United States (19/3300 x 10) are induced cancers. There are also, however, substantial attributable to vinyl chloride and about 0-13% in numbers ofcases occurring after longer time intervals, i Britain (7/550 x 10). 13 having been diagnosed 30 or more years after first Two pieces of evidence suggest that an extremely exposure. This means that new cases are likely to be high exposure to vinyl chloride may be needed to diagnosed well into the 1990s even ifit is assumed that induce ASL. Firstly, the fact that so many or the cases exposures were significantly reduced in the mid-1960s were among men working as autoclave cleaners in when the first major improvements in standards of which the highest exposures are thought to have hygiene were made. The mean induction period of the occurred: it was in these jobs that employees some- cases currently on the register (22 6 years) must there* Table 5 Cases of virtvl chloride related angiosarcoma of liver tabulated by years from first exposure to vinyl chloride to diagnosis and years to 3! December 1984 (maximum possible latent period). (Number ofcases expected to occur shown in parentheses*) Years from first exposure Years from first exposure to dale ofdiagnosis to 31 December 1984 5- 10- IS- 20- 25- 30-U Total within 33 or more 35 years >ts 30-34 25-29 20-24 15-19 0-14 Total 2 t 10 12 7 32 8 __ 4 12 7 3 ( + 4) 27 ( + 4) _ J 10 8 4{ + 9> 0( + 10) 25 (+19) _ 4 15 2( + 2i> 0( + 29> 0 ( + 22) 21 (+76) _1 2 -- 2( + T> 0(+lT) _0(4-18) o (+14) -- 5 (+56) 0 ( + ?)t 1 12 32 ( + 7) 32 (+42) 23{ + 56> 10 ( + 50) HO (+155) * (4-7)1 Number of cases expected to occur calculated by comparing proportion of cases in relevant years since first exposure category for previous lime periods with proportion in other categories--for example, for 25-29 years since first exposure and 25-29 years maximum latency expected (34-10 + 8) (2 + 1 + tt + 1-1-4+12) x (12 + 7) x 19 13.3 As four cues have already been diagnosed, anothernine may be expected. fNumberofnew cases to be expected among worker* who had less than IJ years since first exposure at 31 December 1984 unit be dependent on whether the hazard of vinyl cMonde wis eliminated in the Ute I960* orifl thenid*(970)> In the former instance no caw would be expected, in the latter a number approaching the 61 cases projected for those with 15-19 years since first exposure by the end of 1984. tit is virtually impossible to estimate the number of expected new cases 35 or more years after first exposure. s AP00055840 \ ! Exposure to vinyl chloride and angiosarcoma of the liver 753 Tabic 6 Recorded occupations among ASL cases an register ASL at any point in time increases in proportion to (i) the first power of the product of the population at risk Nom and the degree of exposure and (ii) a higher power Production worker/operator Autoclave cleaner General maintenance/fiiler Other jobs Unknown 69 51 8 1) 17 t36 (most probably the third) of the time since exposure first occurred.* Knowledge of the distribution ofcases recorded by the National Institute of Occupational Health and Hygiene (1982) by year of first exposure and year of occurrence, the amount of vinyl chloride *As several employees have more than one job recorded for them, these numbers do not add up to 118. produced, estimated average exposures at work at different periods from before 1950 to 1970-4. and lore be expected to be materially increased with the normal national mortality rates allowed them to make passage of time. Any method to assess ihe number of expected new cases is likely to be imprecise. Our method simply looks at the proportions of cases with different latent periods and makes projections based on the distribu approximate estimates of the variables in these equa tions and hence to calculate the number of cases that might be expected to occur in the future. Only time will show which of the two methods will give the better estimate of the number of cases that tion of cases that have occurred within different peri ods of maximum possible latency. In the absence of will eventually be observed. We are encouraged, how ever, to think that the lower estimate may be the 1 any information about the numbers of exposed employees it is all that can be done. The results suggest that another 155 cases are likely to be diagnosed within 35 years after first exposure. Compared with the 110 cases in this category diagnosed so far. this means that the industry is approaching the halfway stage in the appearance of ASL. The calculation of nearer as the method of Nicholson et at predicted an increase in the annual number of cases after 1979, whereas the number recorded to date has declined from an average of 9*2 in 1975-9 to an average of 6-8 in 1980-4. The latter figures will, however, almost certainly, be revised upwards in the course of the next few years owing to delayed reporting. 155 more cases within 35 years of first exposure assumes that the hazard was essentially eliminated in the late 1960s. If it was not a further 50 or 60 cases References (something slightly less than the number expected to have been induced in men who could have been ` Viol* PL. Pathology of vinyl chloride. Med Lav I970;6I:I7J:SD. observed for only 15 to 19 years by the end of 1984) must be added to the total. Further cases must also be expected to occur 35 or more years after first exposure but it is, as yet, virtu * Maltoni C, Occupational carcinogenesis 2nd International Sym posium on Cancer Detection and Prevention. Bologna. 1974. In: Advances in Honour prevention, detection, and characterisation. Vol 2. Amsterdam: Exeepta Mediea, 1977, ' Creech JL. Johnson MW. Angiosarcoma of the liver in the manu ally impossible to estimate the number to be expected with any precision. It could, however, easily be around 50. We suggest, therefore, that it should be assumed that there will be another 200-250 deaths from vinyl chloride related ASL over the next 30 years. This estimate is in pronounced contrast with that calculated by Nicholson et at who suggest that "within a factor of 2 or 3" there will eventually be a facture of PVC. J Oecup Med t974;l&|9-2. 130-1. ' Maltoni C, Lefemine 0. Carcinogenicity biouuys of vinyl chlo ride. Environ Res I974;7JI7-40S. 5 Bames AW. Vinyl chloride and the production of PVC. Pro- eeedinfs ofthe Royal Society of Medicine 1976;69:27T-B0. * Fox AJ. Collier PF. Mortality experience of workers exposed to vinyl chloride monomer in the manufacture ofpolyvinyl chloride in Great Britain. Br J Ind Med 1977:34:1-10. ' Baxter PJ, Anthony PP. MacSween RNM. Schauer PJ. Angio sarcoma of (he liven incidence and aetiology in Great Britain. Br total of 350 deaths from vinyl chloride related ASL in the United States and 1200 in Western Europe alone.* Nicholson et at used acomplex model to deduce these figures based on the assumption that the incidence of J Ind Med 1980;37:213-21. * Nicholson WJ, Henneberger PK, Tarr D. Trends in cancer mor tality among workers in (he synthetic polymers industry. In: Industrial hatards ofplastics and synthetic elastimert. New York: Lis, 1984:65-78. AP00055841 L* if i \ CONFIDENTIAL World Register of Cases of ANGIOSARCOMA OF THE LIVER (ASL) due to VCM REVIEW DATE 1st JANUARY 1989 ********* Collated by: Dr Brian Bannatt Occupational Health Id Chemicals and Polymers Ltd HillhouseSite POBox 4 Thomton-Cleveleys - (Telephone Blackpool FY5 400 (Telex England (Facsimile 0253 861632 J 67483ICIPLHG) 0253 861861 / AP00055842 liver AJTCMSARC0MA CA5E5 CIRCULATION of REGISTER CONFIDENTIAL \ . FEBRUARY 1989 APPLETON B BAGSHAW Dr I MM ICI Runcorn, UK Hydro Polymers Ltd, Newton Aycliffe, UK band Dr p a BARON Dr C BARRA! Dr G BAXTER Dr Peter BAYLAC Dr gELLEC Dr pENECH Dr M BENNETT Dr B Cancer Control Agency of British Columbia, ICI Runcorn, UK AECRP, Commentry, France University of Cambridge, UK Atochem, Chauny, France Rhone Poulenc, Aubervillers, France Naphtachimie, Lavera, France ICI Hillhouse, UK Vancouver, Canada BERTAZZI Dr P gERTUZZI M Inst of Occupational Health, Milan University, Italy EVC, Brussels, Belgium BEYNON D W S BISHOP Dr C ICI Runcorn, UK EMAS, Cardiff, UK BORREt^ F E BRAUN Dr C L J BREWER Dr H D Georgia Gulf, Delaware City, USA Akzo, Arnhem, The Netherlands Imperial oil, Sarnia, Ontario, Canada BRYSON Dr D D BYREN Dr David ICI Wilton, UK Nobel Industrier, Sundsvall, Sweden CARTER Dr J T CATANZARITI A i CELLA C CHANCE M k I' CLARKE Dr E A EMAS, London, UK EVC, Brussels, Belgium EVC, Brussels, Belgium ICI Runcorn, UK Ontario Cancer Foundation, Toronto, Canada CLAYTON H CONTASSOT Dr J C Norsk Hydro, Newton Aycliffe, UK Atochem, Saint-Fons, France DAVIES J G D JONG Dr G EVC, Brussels, Belgium Shell, An Den Haag, Holland DELORME Dr F Quebec, Canada DEPLAN Dr F Atochem, Jarrie, France DIETZ Or H W B F Goodrich, Akron, Ohio, USA DOLL Prof Sir Richard Imperial Cancer Research Fund, Oxford University, UK DOMBROWSKI S L S DRUMWRIGHT Dr J R DoW Chemical, Midland, Michigan, USA Vista Chemical, Houston, Texas, USA DUPONT G emminger h APME, Brussels, Belgium VKE, Frankfurt, Germany ERNST Dr W Berufsgenossenschaft der Chemischen Industries, Nurnberg, Germany EVANS Dr A E J Lever Bros, Warrington, UK FALK, Dr K Centres for Disease Control, Atlanta, Georgia, USA FAVRE Dc Atochem, Montluel, France FIELDING Miss C ICI Millbank, London, UK FILLINGER J Solvay, Brussels, Belgium FINCHAM Ms Shirley Alberta Cancer Board, Edmonton, Canada FOA Prof V Inst Industrial Medicine, Milan, Italy FORMAN Dr D Imperial Cancer Research Fund, Oxford University, UK FRASE R W DiversiTech General, Akron, Ohio, USA FREIESLEBEN Dr W ECVK, Brussels, Belgium FRIEDEL Dr H P Berufsgenossenschaft der Chemischen Industries, Heidelberg, Germany GAFFEY Dr W Monsanto Co, St Louis, Missouri, USA GOTTESMAN R T The Vinyl Institute, Wayne, NJ, USA GROISHAN D Electrochemical Industries, Acre, Israel HILLMAN Dr D W Diamond Shamrock Corp, Dallas, Texas, USA HOWARD Dr J K University of Otago School of Medicine, Wellington, New Zealand HUMPHRY Dr N F I ICI Australia, Melbourne, Australia j WPX/ASL - ASL^AUDRESS, 1 ' "! A AP00055843 JOHNSON Dr C A JOHNSON Ray W KAIPERT Dr J H KLEIN Dr H LAGAST Dr H LANHAM Dr John LANOUZIERE Dr Claudine LAWRENCE--JONES Sir C LEE Dr F l LELBACH Prof Dr WK. LEVEQDE Dr G LEVISON Prof Dr D A LEWIS Dr P LIGO Dr R N LO KARTIRE Prof N LUSS R D LUSSATO Dr Jo9ette MALTONI Pt'of G MATTIUSSI Dr R MELTON B MIDDLETON D KOKKA Mr MONTESANO Dr R MOTTI Dr A A MUNOZ MOUTON Dr M MacSWEEN Prof RNM NAKAMURA Dr S OSMAN Dr J PADDLE Dr G M PAGLIALUNCA Dr S PAQUET Dr Christiane PATERSON Dr J C PIRASTU Dr Roberta POSSBERG Dr J PUECH Dr A M PEJRDHAM Dr J RAMBAUD Dr J RICHARD Dr A ROBSON Mrs D RODRIGUES Dr MJF RUTY Dr J SALG Dr Joyce A SCHIPPER Dr H SCKCTCKMANN Dr F SERONNE Dr D SHAH Dr Has SIGRIST Dr J SIMONATO Dr L SMITH Prof Allan H SMITH J S SMITH Dr P M SPIRTAS Dr R STAFFORD Dr J STAHNECKER Dr E SULAIKAN Dr -2- Goodyear Tire & Rubber, Akron, Ohio, USA GenCorp, Fairlavn, Ohio, USA Dow Chemical Europe, Horgen, Switzerland Dynarait Nobel, Troisdorf, Germany Solvay, Brussels, Belgium Dow Chemical, Midland, Michigan, USA Solvay, Tavaux, France Chief Medical Officer, ICI, London, UK Victoria Hospital, Blackpool, Lancs, UK University of Bonn, West Germany CDF Chimle, AZF, Buily-les-Mines, France Guy's Hospital, London, UK Chemical Industries Association, London, UK Dupont, Wilmington, Delaware, USA EniChem, Milan, Italy Occidental Chemical, Pottstown, Pennsylvania, USA Atochem, Port de Bouc, France Institute di Oncologia, Bologna, Italy Montedison, Milan, Italy Formosa Plastics, Delaware City, USA Hydro Polymers Ltd, Newton Aycliffe, UK Neste Oy, Espoo, Finland IARC, Lyon, France Duperial SAIC, Buenos Aires, Argentina Rio Rodano, Madrid, Spain Western Infirmary, Glasgow, Scotland Japanese PVC Association, Tokyo Health & Safety Executive, Bootle, UK ICI Central Medical Group, Alderley Park, UK Montedison, Novara, Italy Atochem, Serquigny, France ICI Runcorn, UK Istituto Superiore di Sanita* Rome, Italy Wacker-Chemie, Munich, Germany Atochem, Brignoud, France University of Toronto, Ontario, Canada RP Recherehes, Antony, France Rhone Poulenc, Roussillon, France Saskatchewan Cancer Foundation, Regina, Canada ICI, Sao Paulo, Brasil Atochem, St Auban, France NIOSH, Cincinnati, Ohio, USA University of Manitoba, Winnipeg, Canada Hoechst, Frankfurt, Germany Diamond Shamrock, Dallas, USA CMA, Washington DC, USA Shell Chimle, Berre L'Etang, France IARC, Lyon, France University of California, Berkeley, USA ICI Killhouse, UK Llandough Hospital, Penarth, UK NCI/NIK, Bethesda, Maryland, USA Somerset, UK BASF, Ludwigshafen, Germany Arabian Petrochemical Co, Saudi Arabia WPX/ASL - ASL ADDRESS,2 AP00055844 -3- \ TACHHCI Dr H TAMBURRO Prof CH ten BERGE Dr W F TENKHOFF Dr N TEPPER Dr L B TERWIESCR Dr B THERIAULT Dr Gilles THIIS-EVENSKN Dr E THOMSON Dr D H TONER H P VAN DER MBRWE Dr H J WALLACE J R WALTEMATE H WEJDLING S 0 WILLIAMS Dr DMJ WILSON Prof R YORK J YOUNG A E ZOBER Dr M A Hoechst AG, Frankfurt, Germany University of Louisville, Kentucky, USA DSM, Geleen, The Netherlands Huls AG, Marl, Germany Air Products, Allentown, Pennsylvania, USA Huls AG, Marl, Germany McGill University, Montreal, Canada Norsk Hydro, Porsgrunn, Norway Cancer Treatment & Research Foundation, Halifax, NS, Canada Society of the Plastics Industry, Washington DC, USA AECI, Sasolburg, South Africa Esso, Sarnia, Ontario, Canada BF Goodrich, Cleveland, Ohio, USA Norsk Hydro, Stenungsund, Sweden BP Chemicals International, Barry, UK Harvard University, Cambridge, Massachusetts, USA EVC, Brussels, Belgium EVC, Brussels, Belgium BASF, Ludwigshafen, Germany From: Dr B Bennett, Occupational Health Department, 1CI Chemicals & Polymers,, Hillhouse Site, PO Box 4, Thomton-Cleveleys, Blackpool FY5 4QD, England WPX/ASL - ASL ADDRESS,3 AP00055845 CONFIDENTIAL REGISTER OF CASES OF ANGIOSARCOMA OF THE LIVER DUE TO EXPOSURE TO VINYL CHLORIDE - REVIEW DATE 1 JANUARY 19^9 PREFACE : ACKNOWLEDGMENTS, SIGNIFICANT CHANGES, COMMENTS AND REQUESTS 1 The ? new cases in the Register are the following: Canada 13? France 23, 24 and 25; Italy 07; UK 15 and 16, 2 There ere amendments from the previous Register against the following cases: Canada 11 and 12, UK 14 and US 41. 3 I would like to thank the following for information about new cases: Dr Dietz, Dr Contaseot, Dr Lagast, Dr Benetta, Dr Williams, Dr Smith, Dr Lee. 4 For additional information about other cases I thank also Dr Delorme, Monsieur Bibeau, Dr C A Johnson, Mr Roy N Johnson and Professor Lelbach. 5 So far as I know the following people are still alive: cases France 15, 22, 23 and 24; Germany 31 and 32; US 33 end 36. Is this correct? This is important information for the industry world-wide and I would appreciate news, especially regarding the cases in Germany, please. 6 Tables 40 and 4h have been enlarged by the addition of the factories at Tavaux (France) and Hillhouse (UK), as each of these has now had 4 cases. 7 I should be glad if s') 1 recipients of this Register would continue to keep me fully informed of any new cases, or give the name and address of someone who can send me the necessary details. 1 have again attached a blank sheet at the back of the Register so that information can be supplied under the appropriate headings, so far as possible. Please also send any other relevant information about earlier cases, or about factory changes. 6 RESEARCH: (a) May I again ask that all individuals involved in relevant research keep cue informed and if possible send me reports. Perhaps recipients of this Register would pass on my request. (b) Co-factora - I have recently met Professor Carlo Tamburro at the University of Louisville, USA, to assess the data which many of you kindly sent in response to my questionnaire about possible co-factors with Vinyl Chloride. We found there was no correlation within Europe but among the North American cases there was a suggestion of a co-factor effect on latency. In plants where Di-Ethyl Maleate had been used, the latency period seemed to have been shortened. 9 There was an excellent response to the circular I sent in June 1988 about the Register mailing list. Thank you. Please continue to keep me up to date with news of retirements, movements and changes of addresB. AP00055846 FROM: Dr Brian Bennett, Occupational Health, ICI Chemicals 8r Polymers Limited Hillhouse Site, P 0 Box 4, Thornton-Cleveleys, Blackpool, FY5 4QD, England February 1989 BB/BGS Index 1CI CHEMICALS & POLYMERS LIVER ANGIOSARCOMA CASES (REVIEW DATE - \ JANUARY 1989) | ~~~~------ UPX/ASO - LANG10CASES,4 Table Sequence Belgium Canada Czechoslovakia Page 1 1 AS1, Case Numbers by year of Death (Table 6) 2-3 ASL Case Numbera by year of first exposure 4 (Table 7) Page 46 47 France Germany Italy 5-9 1 Western Europe PVC Producers - Start-up Dates vs ASL Cases 46-49 (Table 8) 10-15 1 USA PVC Producers - Start-up Dates vs ASL Cases 50-51 16-17 (Table 9) l Japan Norway Sweden 18 Canadian PVC Producers - Start-up Dates vs ASL Cases 52 (Table 10) 19 East European PVC Producers - Start-up Dates va ASL Cases 53 20 (Table 11) UK USA Yugoslavia 21-24 Japanese PVC Producers - Start-up Dates vs ASL Cases (Table 12) 25-32 South & Central American PVC Producers - Start-Up Dates 33 l (Table 13) 54 55 Incidence of Cases per annum (Table 1) 34 Australasian PVC Producers - Start-up Dates (Table 14) 56 Distribution of Cases by Country (Table 2) 35 Middle Eastern PVC Producers - Start-up Dates 1 (Table 15) 57 Pattern of Cases by Factory (Table 3) 36 Blank form for notifying new cases 1 - AP00055847 Latency Periods (Table 4A) Distribution of Latency Periods (Tables 48-4H) 37 38-44 l Annual Geographical Incidence (Table 5) 45 1 Page I elcum IC1 CHEMICALS 4 POLYMERS LIVER Angloaarcaaa Caaea - (ifview tale : 1 January 1989} MVX/ASI, - LA*U10CA$ES,6 1 COUNTRY AKA REFERENCE NO BELGIUM 01 02 1 Z| 1 NAME M | INITIALS i l i l 3 BATE OF birth 112.01.U 1 1 1 1 1 1 l t 1 1 J I 1 1 1 \ 1 1 1 1 1 1 1 1 1 t 1 1 * 1 Si |29 09 40 1 t 1 t 1 1 l * 1 t * i { 4 1S 1 COWAMY | FACTO*Y 4 FIRST VC urosm 7 BATE OF OIACHOSIS e ACE AT OIACHOSIS l Solvay I Jeaeppa 00.07.58 00.05. 76 63 Solway J*aapj>e 20 08 62 00.10.79 39 TEARS OF EXPOSURE TO DIAGNOSIS IS 17 10 11 12 YEARS OF EX resORE DATE OF DEATH HISTOLOGICAL CONFIRMATION 17 29.06.76 Yea 9 23 10 S3 Yaa -- .. 1 13 | I* l 1 ESTIMATED | EXPOSURE OCCUPATION LEVEL 1 15 | 16 OTHER CAREER HIGHLIGHTS l 1 1 l oTHtR COMMENTS Nl|h j Aucoc leaner |I4 yra 19)8-1968 1 enpoaed to|Polyworker 200 ppaa 3 yra fur 6 hra per day and certainly | under 500 ppa In 6 Co 93 ] | | autoc t avea1 lis-IP?2 l expeecd to| 50-200 pfa| 8 hra par | day In | 35*3 | utoc 14ve { 1972-1974 ( espoaed to) 50*200 ppa| In auto- | clave rooal 1974-100 | PP 1 1975- 50 | PP* RETIRED 1 | 1 Feb 1975| 1 1 08.62-03. |Aulucleaner 63 01.67 (5 yra 5 ( ha -111.71 (Operator 20(1 PF* Bti/day |3 yra 9atlia. | 04,61-12. | 6 b * 200 | PP* 1 1 1 1 1 1 1 1 Driller In 4 (Mesial I c tet foundry |tn Oct 19/4 (2 yia) [were nuiaal. Faraer | Ret 1 red (15 yra} iFeb 1975 WarH In gl*>* |Hup 11 a 11ed |nd. 6 cheat- |Hay |976 C*i | t L'uap lets |Clinlcal and | airr r delalla fare given in a [paper by | Hub let el at |1n Arch. BelR. |Ned. Sue.. |Hy*. Med. |Tree. ned. 1 Leg. ( 1977 peg a* 1601-627 1 1 1 1 1 Flreaan aliice |lai hIrii || r 10 71. | 791 Thorm i , 1 paln U7. )1 . | He pal 1 r I r r, i > (at rerrd t:> . . (Poe ItIv. lertiuRi aph, 111.79. It,.,,., 11 n 1 i>ay 11/ . HO . lUK-.dir, ,,iy. | lol.xaal I Id !.<. ( (!.(<<( 1 l r,... 1 i /.. i i i>, AP00055848 Page, 2 CANAJM Sheet 1 1C I CHEMICALS A POLTHERS LIVER Angloaarcaaa Came# - (Review Sate: I Jan 1909) DAY - MOUTH - YE At Aik date* oac UK eyarea WX/ASL - lANClOCAStS. I 1 COUItTSt AMD reference MO CAMAJM 1 21 1 t NAME OR | INITIALS | 1 1 1 1 1 31 | 1 DATE OF 1 IIRTM 1 1 ( 1 1 1 4 t5 COMPANY 1 I 1 | FACTORY 1 1 1 SNAWINICAN ---------------------- 1 0 FIRST VC CXPOSURE DATE OF OIACNOSIS 1 81 9 1 ACE AT 1 | TEARS OP OIACNOSIS i EXPOSURE TO | DIAGNOSIS ... 1 1 1 11 10 111 1 (2 11 11 TEARS OF | DATE OP | HISTOLOGICAL EXPOSURE | DEATH | CONFIRMATION 11 1( 11 11 11 13 1 14 1 k1 1 ESTIMATED 1 1 ( EXPOSUIE | OCCUPATION | LEVEL 1 1 11 l1 11 IS OTHtW CAREER HIGHLIGHTS 1 1 1 1 | ( 1 1 1 1 14 OTHtH COMMENTS 01 02 03 09 05 OR 07 OR 1 09 1 |IS.12.13 1 11 1| 11 104.03.14 1 11 lk 1| 11 I24.0B.I9 1 11 11 1| 11 105.04.19 1 11 11 1l 1| 11 |07.OS.11 1 11 11 1 1 115.12.14 1 I 1 1 1 11 1| 11 109.11.19 k 11 11 | 11 111.OS.20 1 1 1 1 |19.07.2k 1 1 1 1 11 i1 11 1 1 1 I 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 I 1 1 1 1 1 ( 1 1 1 1 1944 1943 I95S 1957 1941 1942 1945 1967 1944 1964 1947 1971 1944 1972 1961 1946 197) 1474 41 1 1 1 1 4) 1 1 1 1 1 42 1 1 1 1 1 48 1 1 1 1 I 1 S? ( l k I 1 SI 1 1 1 ) 1 S) 1 1 1 1 1 S3 1 t J t 51 1 1 1 1 U 14 21 22 24 24 26 12 ? 11 102.09.55 | 11 JL I1 14 121.12.57 | 1I 11 11 11 20 123.03.62 | 11 11 11 11 22 |2k.01.6* | 11 11 11 11 11 05 105.07.60 | 11 1k 11 1f 23 110.04.71 | 11 11 11 11 25 124.12.72 | I1 11 11 11 05 112.06.73 | 11 11 11 26 |04,09.74 | 11 11 11 Tea Yea Tea Tea Tea Tea Tea Tea Tea (Reactor (cleaner [Operecuc (Seeker Ipolynerlaatlo n| 11 11 (Halnranance (Operator 1 1 (Worked iBlUvrlgtic , 1 (pipefitter 1 (eve rilae | Smoker 1 1 (Operator, (foreman l 1 1 1 1 I 1 1 (Worked |ove r i lae (Morv-aaok e r 1 1 (React or 1 i (Ope tac or, 1 1 (Worked Ic leaner I foreman, (overt tae 1 1 k 1 (Reactor (water I uni t 1 1 (Water coo Ik up coo 11 <>| |Sacke i 1 1 1 1 Worked leleaner (unit levelllae 11 | Smoker 11 1 1 (Reactor (cleaner 1 | Maintenance, (11 Ivrljhl 1 IWorked (overt Ime 11 (Smoker 1 1 (Reactor |c leaner 1 1 1 1 (kVchlne ehop (operator and Ipoly unit 1 1 1 | Worked (overt lae |Saoker 1 1 (Reactor |C leaner 1 (Maintenance (machine ahop 1 (In plani 124 yrul Sen*,.. 1 1 | Furnace op. Iplpelliter (aim enrni r 1 1 1 1 1 1 1 | Wtrr b erl loved lae | Saekei 11 1 Haper hr Ur f BtLuRNE in Amialea d'AxecoBle patholoplquc Parla, 1978 Veil 2) No 2 ppl05-|(4 clilw thl* caac had b<h 4 hepatou and ASL ili|itiicm<lr AP00055849 "1 Page ) CANADA Sheet 2 ICI CHEMICALS l POLYHEKS LIVES KnfloMicou Cases - (Review Date: 1 Jan 1989) DAT - MONTH - YEAS All dac.ee uae US ayatea WPX/ASL -- LAHUlOCASES.a 1 COUNTRY AND REFERENCE HD CANADA I 2 13 1 1 NAME 0* | DATE OF INITIALS | HATH 1 i1 -------------------i 6 coHPAirr ll 15 | a 11 11 1 1 FIRST VC | FACTORY | exposuae 11 11 1i I1 7 DATE OF DIAGNOSIS 8 ACE AT DIAGNOSIS 9 TEARS OF EXPOSURE TO DIAGNOSIS 10 \ 11 LC 12 1C IIS.OS.i5 1 1 1 1 1 113.10.25 Culf 1 1 1 1 11 A.04.20 Calf 1 1 1 1 1 1 1 1 | 1951 1 1976 1 61 1 23 11 11 11 11 (Shawinlgsa mi Mo* 85 60 62 11 11 11 l1 1 (Shavlnlgan ms Mar 82 61 37 11 11 11 11 11 11 I1 1 10 I 11 1 1 TEARS OF | DATE OF EXPOSURE | DEATH 1 1 1 1 12 HISTOLOGICAL CONFIRMATION 1 13 1 16 1 1 ESTIMATED 1 EXPOSURE | OCCUPATION LEVEL 1 1 1 1 1 1 | | 15 OTHER CAREEN HIGHLIGHTS 16 I 00.0*.?? i i i i i 5 105.06.86 1 1 1 1 27 |31.03.82 1 1 l 1 1 1 1 Tea Tea Tea 1 | Reactor jfurnacc op. |c leaner (Maintenance, 1 (packaging 1 High High Lew 1 1961-67 (Operator 6 (Supervisor |VC Plant 1 1 11965-55 1 Awtec lava (Operator. |fVC Resina 1 | 1956-65 |VC IManuf eelwre [Retired 1472 IfAge 67) IRerlred 1977 KAge 52) 1 1 16 1 1 | OTHER | CUrtHEHTS 1 1 1 1 1 lEx-aeoker 1 1 1 1 (Letters Ifoe |0r Fernand | Oe 11> ree, IPathologlac 6 IN 81 bean. RFC 1 (Letters (roe |Dr Fernand (Oeloree, (Pathologist 6 |M HI beau , Ik; 1 1 1 11 1 1 _L 1 1 1) ss 110.00.26 arc t1 1 1 i1 J_ J _L 1 11 III 1 11 1 1t 11 1 1I 1 11 1 11 1 11 1 *1 1 11 1 11 11 11 11 11 11 | Niagara | I Welland | 11 1957 I9S7 60 30 11 1 --____L l1 1 _L 1 1 III 11 11 1 11 11 1 11 11 t 11 11 1 11 11 1 11 11 1 11 11 l 1 1 11 1 1 1 11 1 1 1 11 1 1 1 1 1 1 1 _L 1 21 126.1.87 1 1 1 J________ ___l III 111 III III III III III III III III III III Tea Had tun l 1965-72 | Aut oc lave lOperatar. IPVC Resina 1957-70 High 11 (Poly CleanerIttetI red 1980 16 Operator 1 ( Age 56) 1 1970-80 | Supervl lot Lew 1 1 || || | 1 |l || 1 | II || || II 1 | | | II 1 II || II 1 | 1 l 1 1 1 l | Inf urealIon |lrne j Dr H H Dim. |IKC, *H8B 1 | 1 1 1 I | 1 1 1 1 | 1 AP00055850 1 Pag* 4 CZECHOSLOVAKIA IC1 CHEMICALS A POLYMERS LJV6E AoRloaarcoaiA Caeea - {Review Date! I Jan 09) WPi/ASL ' LANCIOCAShS.I I |2 | 1I 4 I 5l6 S | 9 | 10 | II | 12 | 13 J4 I5 lb COUNTRY ADD I REFCRENCE | NO | NW OR INITIALS DATE OF RIRTR CZECHOSIOvAKU 01 1 1 i l I l ) i t ( 02 1 1 1 1 I (20.06.28 1 1 1 1 1 1 106.07.2? COMPANY FACTORY FIRST VC urosuti T State Co State Co i i i i Novafcy i i * 1 i Hovtky 1 1 1 1 1 0I.O7.S7 1 1 I t | 1 1 01.11.SO CATE OP DIAGNOSIS AGE AT DIAGNOSIS 24.12.73 27.11.64 1 1 1 1 1 1 1 1 1 | 1 1 45 37 YEARS OF EXPOSURE TO DIAGNOSIS YEARS OP | DATE OP EXPOSURE | MATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS i 1( 1 1 1t 1 ( 11 1 l 11 1 16 ( 16 (24.12,73 1 Yea | ( 11 l l 11 ( l 11 ( r II 1 * I| I 11 14 i IS 126.11.64 1 Yea | 1 ) I (Autoclave (Cleaner I | | | 1 I lAutaclave 1 IIAIC letter 1 ) (of 1-4-82 | Iglvlng decallal (free Pro! 1 | A David of (Centre Ind 1 ( IHyglene and | |Occ dlaeaaea. | 11 11 |IAAC letter of| 1-A-B2 (* aoaewhet altered dale* for this c*c. I have accepted die change* alnce the licet com I roa Pro< A David of Che Ccncre ot Induatrlai Hygiene and Occupac lena I Dlaeaaea, Hy date* coat urlgtnelly fro* HIOSH. OTIlLK COMMENTS AP0005 cn oo cn pgc 5 FRANCE 5hect 1 ICI CHEMICALS 6 POLYMERS LIVER Angloaarcoaa Caaea - (levlew Date: I Jan 89) WFX/ASL - LaNCIOCASES, 1" 3( 5 I6 11 COUNTRY AHO | HAMS OR | DATE OF REFERENCE | INITIALS | (* HO 1 1 L1! 11 FRANCE 1 1 1 01 |H 1 H5.04.2A 11 1 1 1 I 1 02 | S IN 1 1 1 1 <01.06.11 11 11 11 11 11 11 l 1 03 | NAY 1 1 <06.01.20 11 11 11 11 11 J_____ 1 06 |HQ 1 127.01.2? COMPANY *P PC UK If pcuk l l < FACTOtt i 1 I 1 1 |Rouaa| 11Ion I 1 1 1 |Brl|noud 1 1 1 1 1 1 t |$t Fona I i 1 1 1 1 1 IBrlfnoui 1 | FIRST VC k tXPQSUM 1 1 1 1 1 ) 00.01.46 1 1 1 1 t 1 I 06.07.59 ( * 1 1 1 1 1 I | 00.00.46 1 1 t 1 1 1 1 I 19.10.49 29.01.3S rlgnoud 18.01.63 DATE OF DIAGNOSIS IS.02.67 15.01.75 15.01.25 16.01.76 Mit Kt DIAGNOSIS 43 63 65 49 YEARS OF EXPOSURE TO DIAGNOSIS 21 16 29 26 YEARS OF EXPOSURE DATE OF DEATH 19 19.02.67 12 24.01.75 29 29,06.75 28 04.01.76 11.05.76 HISTOLOCiCAL CONFIRMATION Ye* Yea (KIOSK no tOHtnc) Yea Yea ESTIMATED EXPOSURE 1 t OCCUPATION | OTHER CAREER 1 | OTHER | cuhpents LEVEL | HICHLICHTS 1 1 ________ l1 1( 1 1 t High 1 (Autoclave (worker end (cleaner 1 19 yra 1 1 1 1 1 1 1 1 Ref . Ravlcr |*1 Ari-H. Hal. IProi. 1 30 ti ll Hov 7 3 |p 17|-|77 11 1 High 1 12 yra on 1 (Italian ( | Kef . [aonoaer (origin (C Somietun ec (10 yra an Ipolyaer| laaclun 1 1 1 1 t 1 |al "Nouvel 1 e (preaae laedlcale (5 Nov 1977 (P 7)5 High 1 1 | rolyworker 11 11 |VCH produc t Ion |Ref . Retjr cl I 10 yra aa 1 16 yra (el Arch. Ha 1. laucoc lave (Italian POW |Pro!. 1 V n' Icleaner (Shepherd, (6 June 77 | Coapoondlng (Sawyer, Maaon |p 531-355 1 3 yra 1 1 High 1 1 iMonoaer I product Ion 1 1 1 ) 1 (worker I 6 rra I PVC If111 rat I on High I IS tra I___ I | Pa I /work III yc* II |DThoracoloey |Jtf. P U;* |9ih Feb 1976 |ei el "Sc* (coaral <dea Ujspii |ang loaarcoaa | MJ Srpii-nii ( 2) Sc Ini Igr apliy >1976 | |ound ASL | 1)Herat!r rha | Previously I. | tiune |(ro- ASJ. | <i JRIghl | llrpet rc.1 uey I I (anglu.jo i.o.. |Al*o | Pi I I i l-.sll (a I "1..1 | Pf rr..i' IV .Jl , 17 l li Inly N/ Hn'. AP00055852 Page 6 FRANCE Sheet 2 1CI CHEMICALS 6 POLYMERS LIVER AnclN*rcoaa Caeea - (Review Date: 1 Jan 1989) WPX/ASL - LANGIOCaSES,11 COUMTRV AND REFERENCE NO NAME OR INITIALS DATE OP im FRANCE 06 07 1 1 \9* i i t i i i i i t i 1CIR 1 11 U4.0t.34 t FCUK i1 i1 i1 i1 iI i1 i1 i1 i> i1 i1 126.04.27 1 V 11 OS 01.04.J4 Solvay OB. 10. I* FIRST VC exposure DATE OF DIACMD51S ACE AT DIAGNOSIS YEARS OF eRPOSURE TO DIAGNOSIS YEARS OF exposure DATE OP DEATH msToiocrcAL CONFIRMATION I ESTIMATED | EXPOSURE | OCCUPATION LEVEL | 15 OTHER CAREER HICHLICHTS OTHlk OJMMt-HTS 11 11 1 I 1 t llrigoeud 101.03.5* | 12.0*.76 1 42 1 IS ii i 1 ii i 1 ii i 1 (i i t ii i 1 ii i 1 ii 1 i i 1 ii i 1 i i 1 ii i (Sc Auban | 01.07.50 | After 1 1 49 26 l1 I Neath 1 00.07,76 21.OS.57 03.12.75 10.01.At 26.04.76 t) 1 11 11 1 1 1 1t 11 | 1 1 13 | U.QS.H | 1 (OilOSH | 1 leeye ( 1 |I2.09.76)| Tea 1 Moderate 1 1 1 (1 1(1958-1960) | 12 yre | (filtration | (10-M yre | 1 | Tli 1 a nan had (AOL prior C o (AS. Ann, de (Mel. Paul. 1 11 J Ipolywotker ( IJuly '}> 1 11 1 I1 1 (and work. | 1 llebT | tp 6A5 6 6. (AOL ... found 1 11 1 11 11 11 1 1 lie 1971 five (yra befcie 1 11 11 1 (ASL 1 11 |1 1 1 1 t1 tI 1 1 1 27 102.07.76 | Yes 1 High | Plant fore- | 1972- > edeln (Died of 1 1 1 (KIOSK no 1 (aan In Jaectlon In |aeptlceeala (polyaer- {1 1*1lOfl I 1 SmI 1 liver (lealtxi luuevd |llei 30.01.77 I It yre packer J_____________ I | Had been |l autoclave (tunnel urln (clnr |I4 yra (autoclave worker | prevloualy I I 25.12.77 I Very High (Polyeer- 1941-1966 |leatlcin Leaaer (operator, Eepoaure |au< or leaner, 1966-1976 (autoclave lealnteoance I I I I 1 I I I 10 yre In aulplhirlc acid factory, acorekeeper 4 general ervicea |Ope rated 4. It (for reaova I <>! | tueuur it,aa | liver and |d led el I a (second |aurKlral Joperar I un (.,> | b11lo (brom-li lal | f lilult (Pepei by I Or Del y .: i II n At clil . L -, ,1,. |hUJ aile t |Pi ul r->a I....... .. , f Vo I ill re, imv I'.lgr, | / 4 I - J. AP0005585 T Page 7 [Cl CHEMICALS A POLYMERS WPX/ASL - UNCIOCASES.I2 PRANCE Sheet 3 LIVER Aitgloaarcoma Caeca - (Review Dace: I Jan B9> 1 COUNTRY AND REFER!MCE NO Franca 21 1 1 KMC OR | INITIALS | 1 1 t 1 ii i i DATE OF | IIKIN | 1 1 P 1 4 COMPANY li isj6 i i | 1 1 i FIRST VC | DATE OF | FACTORY xxrosuu i DIAGNOSIS 11 11 11 11 R ACE AT. DIAGNOSIS 9 YEARS OF EXPOSURE TO DIAGNOSIS 10 YEARS OF EXPOSURE l> 1 17 1 1 1) i i4 1 1 11 1I DATE OF | HISTOLOGICAL | ESTIHATEO ( | DEATH | CONFIRMATION | EXPOSURE | OCCUPATION 1 1 1 LEVEL 1 | 1 I1 1 (l ( 11 15 OTHER CAREER HiCHLICHTS l 1 1 1 1 ( 1 1 P 1 16 . .. OTHEI COMMENT'S to Vf 1 05*19 | Ii 1i (i 1 1 ___ i 15.02. IT 17 tsc Too* i i i i i 1 00.12.36 1 10.01.7R 1 1 1 1 j _L 00.01.41 I2.4M.78 I 58 TT TT I6.0a.|4 PCUK Irlgnoud 04.02.49 00.03.79 65 Solway ii.04.6i 26.06.79 ~nr China Chlale (Formal If) 71 1 21 1 0.01.70 1 1 1 1 1 _L TT J iTTi 1 Yea To' TT iS.06.7i TOOT | *> 1Auc<nlv* 10 yra to JpUd of 1 (cleaner (mechanical (pjlaonary (| (engineering leatollaa 5 1| (Induat ry (day* after (l (1946-1956 (aurgery 11 i High 11941-1946 (polyaer- llaaclon |gencral Ipurpoae | worker (19*4-1972 (VCM (ayntheaia I (MCI 6 (Acetylene) | forcaan ((agent High |de altrlae! (T5T? (retired J___________ IHonoaer (production land polymer IlaatIon Very High I 943-1975 anil (operator (Aucocleaner 17 yre. |Aut o- loperator 19 yra, (Copolymer* 14 yra ( ( I I |194 J-19/5 I A11 ty pea ot (Jobe on 2 yra aa eye I e ICIgar e t1 acchenlc. 10 yra aa citutller In aanlcary ware manufacture (aaoker uni 11 |1974. Ill a Jot 1977 d..v i tOeaophagr*I I ear Iree. |$urglral II atervent i.m I25.U5.79 I (c llil Ihrpaie. I .my | 1975-1979 a lotenance wort Inttral 11-laanul arCure encly |4 aalutenaiir 1975-1979 I in VCM Poly lfio.es* AP00055854 Page 8 FRANCE Sheet A 1C CHEMICALS A POLYMERS LIVER Angtoaar Caeca - (Review Data: 1 Jan 1989) WPX/ASL - LAHClOCAStS.n 1 11 1 COUNTRY AMO | REFERENCE | NO 1 1I 1 2| 1 t NAME OR | INITIALS { 1 1 1 3 DATE OF RIRTH France 1 1 4 COMPANY 11 13 6 | 1 1 | FACTORY FIRST VC EXPOSURE 1 | 1 1 OATH OF DIAGNOSIS B ACE AT DIAGNOSIS 1 19 1 10 1 | 11 1 11 1 YEARS or 1 YEARS 0F| | EXPOSURE TO| EXPOSURE) 1 DIAGNOSIS 1 |1 11 1 11 DATE OF DEATH 1J 12 | 13 | 14 1 11 11 HISTOLOGICAL | ESTIMATED | ( CONFIRMATION | EXPOSURE | OCCUPATION | | LEVEL | | 11 11 11 15 OTHER CAREER HICHLICHTS I t >6 1 | OTHER ( COMMENTS 1 1 |Letc Hepatecc (1983 IS |KF i i i i i \ i 16 |CIH 1 1 1 1 1 101.01.37 1 Chloa ISC Feaa 1 Chlale 1 1 (foraerly 1 1 AT) 1 (1 11 11 t 113.07.22 Chia* 1 |St Fan* 1 Chlale 1 1 (Fanearly 1 1 F) 1 1I 11 1 07.07.SS 116.09.82 1 1 1 17.10.41 OS.01.S3 i 4$ 61 | 27 1 1 1 1 | 41 1 1 1 27 |Aliv i 1 i i i i i i 38 103.04.83 1 1 1 1 1 Yaa Yea (Hlgh-20 yr (Autoclave (Moderate (cleaner (7 yra (1951-1962 | | autoclave 1 (operator | (1962-1982 11 |High-33 yre|Polyaerleet (Moderate- |icm Proceii | Loo - 5 yi* |Man 11 1 (Maintenance | (Worker |J C ConUciol |Letters of (5 10 j 9a3 and 129 i a. 1 1 1 (Retired (Jan 1979. (J C Cone >< ILeCtera of (5 (0 1987 and 125 7 84. 1 1 1 1 17 IHAR 1 1 1 l 1 1 1 1 J 1 16 <R 1 1 1 1 1 1 1 1 1 1 1 1 1 \ 1 i i |22.02.23 1 1 1 1 1 1 1 1 1 1 116.07*62 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Ohio* Chlale (Paracrly RF) 1 I | 1 ISC 1 1 1 1 1 1 1 Pane * J____ Solve? 1 (Tiveu 1 1 1 1 1 1 1 1 1 1 17.06.48 1 09.09.63 1 1 1 | 03.04.83 21.03.64 11 ) t t 60 34 28 103.04.83 1 1 1 1 11 1 1 l 1 42 21 21 (27.12.84 1 1 11 1 1 1 1 1 1 1 1 1 1 l _L ! 1 1 |4 | (Safety i4nt| J1 1 ( 1 ( Yea 1 (High - 1 (Autoclave 1 (Other eeclore (Retired (23 yra (Cleaner (of St Pone l3l.OI.79 | (1948-1471 11eccorjr I97|- |J C Conteiaoi 1I (197a | Letter of 11 |1 10 (98) 11 1 1i 1 11 11 1 11 1 11 21.03.64 161(6-12 refAutoclave 1 (39.01.84 (Low - 9 yie|Cleaner flight 11 (Hepatertoey || (01.05.84' \P (74.09.84 11 jcheweihvr^p/ 1i |lot lung- 11 I1 || 11 1l 11 (| (partial Irealsslun(06.84 - 1Iv<m (reiuf relief. ,10.84 - hint. |rvuluthHi lit 1t I ( tie JlBfjNB l1 AP0005585 e*%* 9 FRANCE Sheet 5 .'.l Clll-.NI CALK k I'lll.'intKS LIVER Anglosarcos Cases - (Kcvl. I Jan 198?) COUNTRY AND REFERENCE HO NAME OR INITIALS DATE OF IRTH 19 IS.12.32 02.03.23 Atochea 21 01.10.40 V 22 13.08.28 IT 07.01.27 IT Do' 08.tS.i6 Atochea TT 02.03.30 Solvay FIRST VC ex result: (MT OF DIAGNOSIS rlgnoud 07.0*.59 26.iO.B4 rlgnoud 1951 27.12.05 SEP Hontlucon 1959 St Aofcan 01.09.56 05.11.8? St Fooa 19TT W rlgnoud 1943 T5BT 1962 ACE AT DIAGNOSIS 52 "5T TEARS OF EXPOSURE TO DIAGNOSIS 25 2? TT 4T 10 TEARS OF EXPOSURE OATE OF DEATH 26.12.85 28.04.86 2b Alive T8 a!T5 or 23 07.03.88 HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL High High High High 1958-70 Low 1970-84 High High IJ yeara) High) 12 y . .i r v ) l./iw ) OCCUPATION OTHER CAREER HIGHLIGHTS J________ _______ _ I l UTRtK | CUHUtMT;; l I |Myocardial Ai(oc I ave operator and clean*r (< nl arcl i<>'i | IVHO.Coioirai y | by paaa I 0MR I. | Let ter I' >n j Dr Coni aat> ii( 15.4.06____________ An toe Iave operator and (Port al In other part (fIbrusle t iimi of factor) 126.04.74. II. * Ioce 1946 | 11Ineaa n (diagnosed s* | preRiaaabl y fwutR relatej |on 20.04.74. | Letter flue. | III Contain. <x ID).04.86 Autoe Ieaner tia I m enan 4 years wo i Re i | HepaC Ic lent 1 Hay 84 nut ..a I . Illrpaitc treat |Hy 8b nlmwi-.l | abnorna III Im. (Letter Inara | D Rarrei I 18.07.84. 12 years Aut oclave wo ike r 14 yeara In Control Rosa Autoclavr (Letters fi |Dl Cuntaae (Atochea 12.12-87 a. |21 7 88. I (Liver Cleaner I all PVC product 1c 11 r snap! ant (Hay I98H. ( Infucaatlran I i iba PVC Produ : l i - 2 yeara HCV De tec t lo - 3 yeara PVC Pr oduc 11 ai nt enai.ee | Ui J C lur.l .r< | At o l* lies , IVHH (Pin I a I I Hcpal er tuny , tBd , Oir.l I..'! ../ I infoiaaii.rn I > I lii Com a.M ni , | Al ...-Itea , | <iNh DO yeara Po 1 yc leaner - 5 years Polyfloor I_________ _ I Pr I a i y M , (l.iai.l Hot*. II.niK. Ural . - 6 y a r h Crmt r .. 1 Ruins - I 2 yc.trs II........... -I')' - IH.Iimr. I l im.mii.ji i.,, I Hi II I.IKI -1 l -...i ... AP00055856 AP00055857 GERMANY Sheet 1 COUNTRY AMO REFERENCE MO NAME OR INITIALS OATS OF urm GERMANY 01 00.00.30 02 1 01 1 1 1 t 1 1 t 1 1 1 t 1 1 1 1 t 1 1 00.00.31 11 (00.00.30 1 11 11 1 1| 11 11 11 11 11 11 11 11 11 11 1 11 1) 00.00.30 12 ICI CHEMICALS b FOL'MERS LIVER Mgloaarcwaa Case* - (Review Oece: 1 Jan 1989) WPK/ASL - LANG l OCASKS , I h 10 FIRST VC IPOSURE DATS OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE BATE OP DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS I I | | I OTHER COMMENT S ___ 01.10.54 19.OS.SB 1 | 12 1 1 1 1 1 l 1 1 1 1 1 1 1 1 1 1 lk.tO.5J 2S.09.J0 11 | 09.06.52 I 00.03.73 11 11 11 11 11 1 11 11 11 11 11 11 t1 11 11 11 11 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 16.04.57 26.11.74 59 45 1 | 1 1 I 1 1 1 1 1 1 1 1 1 l 1 1 1 1 21 23.01.69 Yea (HIOSH) Poly worker 14.12.71 Yea (HIOSH) Polyworker 1 11 11 1 1 | 16 110.10.73 |Yea (HIOSH) 1 (Filling | (Reported tinder 1 11 1 ipeitUiile | (non polfiee t- 1 11 1 lAaroaol cna| (laatIon 1 1 1 |wlth VC | (worker* In 1 11 11 1 (HIOSH Hat of 1 1( 11 1 131.3.77. 1 11 I1 1 IThle ol coulee 11 11 1 |la etrlctly 1 11 11 1 (cotrect. 1 11 11 1 (However 1 1 11 11 1 (wonder 1 11 1 11 11 11 1 1 (whether thle (an had hi gli 1 11 11 1 (eapoaure to 1 11 11 1 |VCH in hla 1 I1 11 1 |can (111 Ing 1 11 1I 1 (apetat Ion? 1 11 1 1l __________ l___________________ l 23.11.74 Yea (MIOSN) 200-300 ppa Polyworker 4 1938 wa |Clinical but high I caysrary aotocI ear | del el I a In during I yr autacleaner foe l yi (paper by autocleaner (Cukel el al iVIrtltowa anli |A Petty IV/6 *2U P 1*5-Jill ( I I I I l I f > "O o o 0 01 Ol 00 cn ItHUiAHY llwn 2 H 1CI CHEMICALS l POLYMERS LIVER Anglaearcoaa Caaea - (Review Date: I Jen 198*) WPX/ASL - LANClOCASSS.lb 1 11 1 COUNTRY AMD | REFERENCE I MO | GERMANY 1 1 1 11 2 |3 1 1| 11 MANE OR | MTC OF 1 INITIALS | IIRTH ( 11 1| 11 11 6 COMPANY s | 1 1 1 FACTORY 1 6 FIRST VC EXPOSURE 1 >a DATE OF l ACE At DIAGNOSIS | DIAGNOSIS 1 1 1 1 9 YEARS or EXPOSURE TO DIAGNOSIS 1 10 1 1 1 1 YEARS OF t DATE OF EXPOSURE | DEATH 1 1 l 1 12 HISTOLOGICAL CONFIRMATION 11 1) 1 14 1 1 1 ESTIMATED I 1 1 EXPOSURE ) OCCUPATION | LEVEL 1 1 1 I 1 1 1 1 1 16 1 >6 OTHER CAREER HICHL1CHTS 1 j ' unit* | CCHMEHTS 1 1 ) Conf1 reed 08 | i (HIOSH glveet a Caia 06} | I 1 1 I 1 < 1 1 1 1 1 1 1 1 06 | 1 (HIOSH Ktvcal C*e 06) I ___________ L \ 07 I l 1 1 1 1 1 1 1 J i 1 oa i i i i i |00,00.3* 1 ii 11 t It 1 | 02.64.60 1 10.12.73 1 i M 13 t1 1 i il 1 i i1 1 i i1 i1 1 t i1 1 i i1 1 i i1 i1 i i t1 1 i i1 i1 1 i i i1 i1 1 1 i i i1 1 i i1 1 i i| | i it k i 100.00.32 1 1 16.12.62 00.00.73 1 68 13 1 1 1 \I 1 1 11 1 1| | 11 k 100.00.26 1 8 1 8 11 1 11 1 11 1 (1 1 IS.04.$4 12.I1.7S 1 J 1 1 1 1 1 69 21 i1 1i I l 1 * t1 1 11 1 11 1 J1 1 11 1 >00.00.17 1 4 1 A 11 1 1I It i i 11 i 1 1 1 1 I9.07.S4 1 06.04.7S i sa 20 l i i1 1 OS |16.12.74 |Ye* (HIOSH) t t i i i i i i i i i i i i i i 12 >09.01,76 1 lea 1 1 1 21 1 (HIOSH aaya 12) 20 113.11.76 1 1 1 l 1 1 1 1 1 1 1 |2S.12.75 1 1 1 1 Tea Yea 1 I 1 { 1 | KC Oieal | |aapa 1 I'cheatstry 1 (laboratorlanl >ln the | {Techno- 1 (logical (Research | | |OepiriaM* > ((HIOSH aaya | I factory | ichealet I |which My be| Iwrong | ItranelacIon)1 11 <1 11 (1 IPVC - Menu- I Ifaccure | (Shift Leader) I1 1 1 IPVCHanu- 1 ( | tlactuie and 1 lali work I llncl onto- I (cleaning | 1 12 yra >(1914-66) 1 < IForcwen Tech| |0ev 8 yra 1 ((I967-197SJ J 1 1 | Po Ijrwuifce i 1 1 | 11 11 1I JL_ T |Reported under | oon-fio lyee r |leacIon {worker! In (HIOSH Hat ol 131.3.77 and 11.78. 1 don't (think UH! la (a correct {classification (by HIOSH. TT>* lean mf have (been Involved {In ven |polyaer(sat Ion (In plloc plant |Of In Min (plant. 1 t 1 1 1 * ) 1 1 1 1 1 1 1 ( 1 1 1 1 1 1 1 1 r*|e CERHANY Sheet 3 12 1C1 CHEMICALS A POLfHEAS LIVER Anfloearcoee c*>e* - (Review Oete: I Jen i*B) UPY/ASl. - LAHCIOCASES ,\1 1 COUNTRY AND REFERENCE NO HAH O* INITIALS DATE Of RUTH 1 -----------j------------------ l GERMANY 1 11 FACTORY FIRST VC exposure DATE OF DIAGNOSIS ACE AT OIACMOSlS 11T (1 1 1 YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOCICAL CONFIRMATION ESTIMATED I EXPOSURE | OCCUPATION LEVEL I 1 11 1 11 11 1> 1 1 OTHER CAREER HIGHLIGHTS I I l 1 OTHER COMMENTS 09 | ( I ( 1 1 1 1 1 1 1 IO 1 (MIOSH Rives ee Ceee II) jooeoo.n i 21 ii ( ii 1 ii 1 ii 1 ii 1 ii 1 ii 1 ii 1 ii 1 2 i 100.00.16 1 1 1 20.02.61 \ it.06.76 ( 1 1 1 1 1 1 1 [ 1 1 01.01.61 00.01.77 1 1 1 1 1 1 ( ( 1 | 1 1 61 60 11 1 13 l24.D3.7a Yea 1 i1 1 i1 1 i1 1 i1 ( i1 1 iI 1 i1 1 i1 1 i J__ 1 J1 16 1 10 (07.01.77 1 Yea III III i I III IIiIII1!111!ISI I Ii iI l Il ill 11 I 100.00.29 | 6 | 6 I I0.I0.5S | 2R.O*.?7 | 47 | 21 (22 |2R.06.77 | (NIOSH fives) I I II I II ee Caa* 10) | || III i I III III I I III III III I II II I i l I II II I I I III III -------------------- J------------ .1. IIIIIl1II!iIL _ I II II I II III 12 ) (00.00,10 | A | A | 00.00.61 | 00.10.77 | 19 | 16 | 6 (07.10.77 | I II >i I If III fee (High i i i i i i i i i i (High peaks peeks |!2 yf poly~| Iwotkcr incl | 1 17Z auto- | (cleve Icl.e.ilng J | |Control rixM| 11 yr 1 1i 11 11 110 yr poly-j lusrkcr Incl |t?Z euto- (cleve |clc<aln( I || | fI0/7S IConf treed (Avereft (exposure liter |9 yre ISO pfm. |t>cc JOOO ftpm . 1 Next ) fil e. |7 1 ppe. last . |yr pv IS pl*e J___________________ 1 leverage (exposure II m |9 yre ISO pfm, (occ 1000 pin i |L*ei yr 17 5 ppe. CUM jlelter of |2I.04.78 ii i | HlRh |3 rre auto- | I iclave I I |cleaner | | 119 yre | I Iftlter | | (operator | i I I | I | | it | 1 |PVC Menu- | | I | I Ifecture I (AuLocleve | f | (worker (os | I (6 yre | I II I II I II I II I 1I I II I II I II I Ijl_ AP00055859 13 GERMANY Sheet 4 1 2 t3 ------ j-------- ----- --- l rraiirrif am REFERENCE MO GERMANY \ 1 MAKE OR 1 SATE Of INITIALS f EIRTO 11 1 f1 tt COMPANY 1 \ FACTORY l 1 t l ICt CHEMICALS V POLYMERS LIVE* Angloaarco*. Caaea - (Review Date: l Jan 1989) UPX/ASL - LAMClOCAStS.U 6| > 1 FUST SC j exposure t 1 1 1 BATE OF macnosis A ABE AT DIAGNOSIS 9 YEARS OF EXPOSURE TO DIAGNOSIS 16 i 1 YEARS OF i EXPOSURE t 1 1 1 1 il 1 1 CATE OF | DEATH | 1 1 1 I 12 | t HtSTOlOCICAL ) CONFIRMATION | 1 1 1 1 11 ESTIMATE!! EXPOSURE LEVEL 1 14 ( OCCUPATION 1$ OTHER CAREER HIGHLIGHTS 1 1 | t 1 1 1 1 lb OTHER COMMENTS 13 1 i4 1 is 1 (NIOSH flv*a| (his Caae 13) t 1 416 1 t i i i i i i i i i < i 100.00.14 i 1 7 1 00,00,*0 ( 04.04*74 1 i1 1 1 l1 1i 1 1 1 l1 1 l1 *i 1i f 1 1 1 l 1 1i l t i 1 1 1i 1i 1 i 1 1 1i 1 l I 1 1 1< ( 1i l 1 1i l 1 1i l 1 1 1i l 1 1 1i 1i l t1 1 1 1 1 1 1 100.00.29 7i ^------ 1------ | ----- i----- 19.I0.53-) 09.10.71"T 1i 1i ti 1l 1 l 1 1 ( 1 1 1i 1i l 1 1 1i 1| f 100.00.23 4 A 1 1 1i l 1i l 1 l 1i 1i li l t 1i 1t l i 1i i 1i l 1i i 1i 1i ( j \i 1 1 10.01.55 I 07.08.7fl ((Laibach (auapected (ASL at | Feb 197$ |laparotoay) | * ( 1 l 1 t 1 1i 1i l 63 4* $5 1 IS 1 14 *19.05.74 J t*' 1 1 i1 i1 t 1 ( i1 t1 1 1 >1 1 i (Hot an [ i |Aogfoaarcoaa | i |la hla letter J i (of 21 12 81, | i Ittr Frlcdcl | i (aaid chla wee ( i |e "Fiaicencpl-I i |tlMlk*rilaia | i (Dar | i ISpelaerohre* | i |(a carcinoma | i |of the | i (oeaophagua) j i (not actrlbut- ( i (able to VCH A | i (not recognlaedl |aa an loduat- | i (rial dlacaae | -------15-------- 23 i1 ----- 13----- Ui.ift.7t i ( ^---------- r--------------- (Autoclave ii i (cleaner and ii i luorker. ii i (Drier ii i Jopcracor. ii i (Later ahlli ii i (leader ii i ii 20 io77S3775" 1 Yea i | ASL and ( High (Auloclare | (worker till i (Hepatocellular | | I9b4. 1 |Carclao*a | (Leader and i1 < |*aat er t1 | 11 i i1 | 1 | ii [ 11 | i1 | t1 1 i1 l i1 l 1 i1 | ( 1 l If W Kit | let ter of 130th June I960 |enc)atln| dti t (fro* |Hr H P Fried* 1 lof K Cheat* | K W teat (letter of 130th June I960 }Acloln| data I fro* (H F mere! i>t |K Cheat< (withdrawing (thla cat. 1 ( I 1 1 l 1 J 1 (Aftgloaarcnea (cent lined (09/79. Suae (derail ol |lii> |t ateo cac (9. 11, 15, lb |t 17 given In (HRU Xepoil lu< 1 1976 JAfiglosercnaa (cunt Iraed, |ful 1 dcl.l la lol lllne.e (aInce Hard. | 1973 RL.rn in |WW Hrii ln,r |Rep lot 19 lb, | 011 Im-i i Idn.lU *1.... | In VC |Ai>vlaied Ibnrr.r l,r 1 Lr 1 ha< > <.| I He I. ( e1ler (< mu J . AP00055860 SOOOdV cn oo CD Face 14 GERMANY Sheet 5 ICI CHEHI CALS 4 POLYMERS LIVER AnglMarcoat Cesea - {Review Date: I Jan 1989) UFKJASL - LAMUIOCAStS,19 l 11 1 1 COUNTRY AMD ) REFERENCE ( MO | GERMANY 1 1 1 1 17 | (NIOSM glvell an Case 1i> | 1 2 |) 1 1 MANE OR t DATE OP INITIALS | BIRTH 1 1 1 1 1 100.00.37 1 1 1 1 I 1 1 I 1 j 1 1 1 1 1 1 4 COMPANY A l 1 | 1 1 1 FACTORY 1 | 1 1 1 1 1 1 6 FIRST VC EXPOSURE 0i.lt.4l 7 DATE OF DIAGNOSIS 14.08.78 ACE AT DIAGNOSIS 41 1 9 10 1 M 1 Ti YEARS OF YEARS OF | DATE OF EXPOSURE TO EXPOSURE | DEATH DIAGNOSIS t l i i 1 14 It (28.08.78 1 1 12 HISTOLOCICAL CONFIRMATION Yea it 1 1 1 19 t 1 1 1 ! 26 1 i i i i i 21 i i i i i i 22 i i i i 100.00.13 | )1 11 100.00.24 | 11 t1 11 ------- 5 ------- %-- (00.00.15 ( 1 11 11 11 1t_ <00.00.13 | 11 11 11 11 11 100.00.21 | 11 I1 ...JL_ i 4 4 1 t 1 1 1 1 1 1 1 i 1 1 l | i t t 1 1 1 1 1 1 1 4 1 oo.oA.ss i i4.~i2.7A~i --SI-- t 1l t | ll.iA.4t 4 1 oo.oe.79 i 44 1i i 1i t 1l l 1 444 (TTTSKTT < 00.04.80 | l1 11 1< 11 1 1 1 i 4 j 01.01.42 | 00.09.79 | (pronounced | X Icliflical < 1 lllrtr | 1 layuptoaa) ( 1 4 t 13.10.41 1 28.08.80 | 1t 1 11 J1 1 1 44 l i 2* 24 It it 19 1 Ti t 1 1 it 1 1 I 1 1 it 1 1 1 i 1 1 it 1 1 1 1 1 1 II 1 1 i__ i24.ii.74 | Yea t1 l1 i2i.A2.4A i Tea i IHetaataelng i (ASL 11 1 ilCifr.so 1 Yea i | Haema ng 1 a i | Endot hel loaa i |e< liver with I IMetutiae* i1 119.00.80 1 Tea 1 1 1 106.12.81 ( 1 (Heeeanglo |Endothelloaa (of liver with IHataeteaee 1 1 Yea (Met aetaaIng |ASL _i 1 1 13 1 1 1* 1 1 14 1 16 1t ESTIMATED 1 1 EXPOSURE | OCCUPATION | LEVEL 1 1 < t 11 fI High (Autoclave (worker 1 | | 1 OTHER CAREER 1 | OTHER ( COMHEMTS HIGHLIGHTS 1 _J___________________ 1 I 1 Ho |Anglouarcna (coni IratL (Ann.ial irptnt lot the Sort l. (Rhine lUeatphalla (Medical |Inipactor^t e |/cir (978 (page* 547-177 Iglvea tull (detal la. V I ny l ichlurldc |dIaeaae (d lagnoaed 102-02-13. |Oecaphagt*l fvarlcea. iRadlolottre) l> (confirmed aero High High High Hlh | Autoclave (Marker 1 1 11 | Autoclave 1 | Mocker 1 11 11 r1 (Autoclave X iMorker 1 11 11 11 1 (Autoclave 1 jUorker and 1 Ivorked In 1 Idrylng ahap 1 1t 1| Au toe lave (poilcr 1 1 (Chaigrtiand, | vuhaeijuenl ly | Korea*n J 1 1 r (Or Beache (letter oi 1|3-04-82 n. (Or W G F yaaa 1 |Dt Beache (letter ol |l 1-04-82 co |Dr M C F Adaev 1 1 |Dr Beache 11 et t * r of 113-01-82 t | Or W C F Ad ana 1 llor ftevche letter i,1 1 l )-li4 n/ i., Dir v t. r A.I ,ni, Page 15 GERMANY Sheet 6 ICl CKKHlCAt.S 4 POl.tm.RS LIVER Angloaarcaaa Caeea ( Rev Uate: l Jan I9SV) UPAIASl. - LMtClOCM.fi i ti t 12 13 A 15| 6 1 _L J___ J COUNTRY AND REFERENCE MO 11 NAME OR | DATE OF | 11 | 1 FIRST VC initials i firm (COMPANY J FACTORY | EXPOSURE 1 > 11 GERMANY 23 1Jl1 11 | OO.OO,27 81 8 1 I 1955 1 t1 1 11 11 1 11 1 i1 _L 24 1 (00.00.2S I 8 ( 6 | 1969 1 11 1 1t J_ 1 25 (00.00.21 8 1 6 1 I960 11 l1 1 1 26 [00.06.21 1 1 J___ 12 1 1 i451 i i i i 25 i io6.&o.ir 11 11 i1 | 1 4 1 1953---------- i 1l i 1l 1 14 l i I 1 1 i 1 t t I 1 1 1 29 1 i t i i \ 31 1 i i 41 1 1 .... ill.11.21 1 1J 1 ( l 1 1 1 1 1 11 11 1 X1 100.00.22 212 1 1 1A 1 1 18 1 J____ 81 8 2 01.10.60 1 i 1 1 1 ( 1 1 1 1 1 11962 1 l iV5i 1 1 11953 1 1 11455 i i1 i 11 i J___ 1 1 11 7|81 9 1 10 1 11 1 11 i 11 DATE OF | ACE AT | YEARS OF | YEARS OF | DATE OF DIAGNOSIS | DIAGNOSIS | EXPOSURE TO | EXPOSURE 1 DEATH 1 | DIAGNOSIS 1 I 1 26.03.79 | 52 1 24 11 11 1 21 129.09.81 1 11 11 1 11 1 1l l 11 1 11.10.82 | 34 1 t4 11 1 ii 128.05.83 1 11 1 11 28.04.81 | 34 1 It t i i4 ii4.oi.44 1 1 1 14.44.74 1 $4 l 22 11 11 11 1 ( 22 ill.11.82 i 11 11 1 11 iB.dr.u 1 33 l 24 i 1 1 I* (02.03.84 11 11 It.08.85 1 41 1 25 1 1 1 1 1 1 I 1 1 1 1 [3,iJ5.84 j l 4t l 21 077tJT7S5 T 42 1 24 l 1 50.06,85 | 61 1 32 l 1 00.04.85 | 55 I 30 1 1 L 1 23 "i2s.08."b3" 1 11 1 i I1 11 11 i1 11 11 1 11 l i4 li3.b2.44 1l i "[25.05.83 1 23 11 1l l 20 lAltvef 11 l1 1 21 (AllveT 11 11 J______________ _ 1 1 1 12 hIstoLOGICAL CONFIRM ATION Yea 1 13 1 14 1 1 ESTIMATED EXPOSURE I OCCUPATION LEVEL I 1 High 1 (Qieatatry (MOO ppa) (Worker 1 1 Tea High (*300 Pf) 1 1 J (Autoclave |Cleaner l Yea High | Pclyc lave (Worker and (Autoclave (Cleaner Tea Nigh ( f Polyuorker Yea High 1 1 1 1 (Autoclave |Cleaner till 11972 Yea High 1 (Proceaa (worker 1947 (81 (01.10.60 1-31.03.8A |EVC pruducc|lon, (agitator (area). Yea 1 1 1 ( 1 --Rip;-- |Cheat airy | worker it* High 1 j Polyworker (Shift l*4er 1 |Au Col lave |r 1 eaner | Po lywurkvr 1 Au 1 or 1 Or l< leaner 1 IS OTHER CAREER HICHLICHTS l ( 16 1 l l | OTHER COftKEHTS 1 1 1 (Prlaary hcpatocellar (carclnoea ; (proliferation ot che (alnuaJudal cella with jalnoaoidal eclaala. | Fricdcl letter 23.12.8b. 1 IProf Eder (Munich) (latter 22.08.83. (Frledel letter (9.04.85. 1 IProf Selwair (Munich! | let ter 27.08.81. IFrledei letter (9,04.85 1 1 (Chronic hepacftla, (angl Mat oslo , t nusold a l (ectaela. Prledel letter (21.12.86. 1 | Lei bach. (Prledel letter |19.04. |Annual VCH acreenlnj (24.04.85: no coaplalut. (no abnoreallty detecled. I (970 two-thlrie (gawt rectoaiy for ulcers. (1971 Coronary <hiot.al | 1983 Feeoral | lapl ant at Ion 11984 Puleonary nbollwe land pleurupneuwonla. ILandera letter* t8.U9.H5 (and 04.02.87. | HaeNangloaarkoaa. (Prledcl letter 21.t2.H6. IHaeaarg1oaarkosa. (rrledet lerler 21. K.hi.. |Haeaglosikusa. | Fried* l Idler J ), 1rt 1,. | Haewang lusii kuna. I Fr ie<U-1 (el ( c-1 7 1. 1 i.h i,. 1 1 AP00055862 Page ITALY Sheet 1 16 1C1 CHEMICALS 6 POLYMERS Live* fcigluaarc** Cate* - (Review Dale: 1 Jan 1989) 1 urx/ASL - i.MtcmcASts ,n 1 COUNTRY AMD REFERENCE HO ITALY 1 2 |3 1 1 NAME OB I DATE OF 1 INITIALS i turn t i i 4 COMPANY 11 | 3I 6 11 11 1 1 FUST VC FACTORY I exposure 11 11 11 01 (On NIOSH oppleentary Hat) LC | 13.06.34 i FANSAC 1 1 1 1 JHLr* I Venice 1 1 1 | 00.00.63 1 1 1 1 1 81 1 DATE OF DIAGNOSIS ACE AT | YEARS OF DIAGNOSIS | EXPOSURE TO 1 DIAGNOSIS 1 19.04.71 1 3* | i i i i 06 1 10 1 1 1 i YEARS OF l DATE or EXPOSLBE | DEATH 1 1 1 03 116.04.71 1 1 1 1 12 HISTOLOGICAL CONFIEHATIOM 7 Yea 1 1J 1 14 1 ESTIMATED 1 EXPOSUBE | LEVEL 1 1 1 OCCU PAT 1 ON IFVC Bag |ezc ruder 1 1 1 I | 1 15 1 lb QTHEB CAREER 1 | OTHER | COMMENTS HICHLIGHTS 1 _J____________________ i l IFrieary Cta"ur |*ay have been Iperlcardlua. (Hot honoIgeneoua with |other ctei. 1 02 ise i I I 0) |YC 1 1 1 1 1 04 | FB 1 113.11.29 1 1 1 114.03.20 1 1 1 1 1 1 120.07.37 1 Mootedleon|Port (Hargheca Solvey 1 1 (Ferrara AM1C 1 1 1 1 1 | Ravenna 00.00.57 00.01.33 00.04.59 13.12.72 10.07.75 00.01.81 1 I 1 1 1 | 1 1 1 1 1 I | 43 ss 43 1 11 15 i 06 127 .12.72 I 1 11 1 11 1 1t 22 1 21 (10.07.75 | 1 11 1 11 1 11 1 11 11 1 11 21 1 21 |30 .03.61 | C Dane*In 19.03.37 FANSAC Hi ra Venice 00.00.67 07.03.83 a Set Nallt.nl tvd ill Uvuru 65 p445, >974. .Fuillurr deni la I ti letter fro* Dr Nontcaano of IAKC on April 1st 1962. Ala*, aer He Itenl and kiH.dltrl li In At is One u I hr I. a Vnl | l 4617 p*R# * I) - 49. Yea Yea (ti 11 i 1 1 Polymarker | 1 1* 11 I 1 .1 1 1 1 1 1 High 1 1 1 1 lAutocleaner | 16 yra ( |*-| |6l) Autoclave (operator | 1 12 yra (1961- 1 1972-5 did | a varl ety o( ( job* 1 Iticlud Ing | PVC packing,) * 1 172) 11 1 12 F< - (1 yr Vary High |Honar | ___L 11 |Mevcr cleaned | autoclave*. | (operator See paper by I * 5 yra - | CHIAPPIMO at (Hon-Moker. Hedlt* 120 yr. - al Med Lavoeo (Conauued |Autoclave Vo I 6 (1982) (little 4 yra l-ow (operator t pp 555-563 |OCh<( dutlra (a Icohel. (ii |A0|.. I In auapena(lon polyaeillaaclan. I I I I |Ar*a Foreman |irt at Dept (elnce J97S, I I ( I J____________ Med lua>~? I I Bag eattude I (S Pag lla l.i.i*;, HI gtl |1967-1975 |lele. (Connercia 1 | 2 Aufl 1' | | Dept 1976( I 945 3 i I J_____ I _____ AP00055863 Page 17 ITALY Sheet 2 ICI CHEMICALS 4 POLYMERS LIVER kit|lMircoM Caaea - (Review Date: 1 Jan 1969) VYIJASL - LhKClttCASliS.il COUNTRY ANO REFERENCE NO MAKE OR INITIALS DATE OF UTH FIRST VC urosutK YEARS OF MR op ACC AT EXPOSURE YEARS Of DIAGNOSIS DIAGNOSIS TO EXPOSURE DIAGNOSIS DATE OP DEATH HISTOLOCICAL ESTIMATED CONFIRMATION EXPOSUAE OCCUPATION LEVEL OTHER CAREER HIGHLIGHTS UIHtR COMMENTS Hontedlaon Porto Nar|hafti Violet 09.02.79 tfeplefan 1998 09.04.86 High 1960-71 Nadlua 1971-74 low 1975-85 PVC wnulictuce II pear* # Autoclave cleaner 1960-71. 14 yaara In Control Hoo* 1971-85 1998-74 Nigh 1974-80 Medlua Maintained VC Hachlner (not operating or cleanlnf autoclave*) VC leva la reduced froa 1973/74 Lettcra froe Dr Chlotxlnii Venlc 22.09.87 and I 1.01.88 Information from La oedlclm lavoro. Italy. VoJ 79 No.J Jan-Feb SB, and Dr Senelta, EnlChem. AP0005 <J\ 00 05 I i Page JAPAN IB ICI CHEMICALS 4 POLYMERS LIVEt Anglosarcona Cate* - (Review Date; I Jto I9S9) WPl/ASL - LAMUIOCASKS.3) COUNTRY AND HEPERE MCE HO HAKE OB INITIALS MTS OP BIRTH COMPANY Toaojt Itorl 01.08.22 Mitsui Toateu Nagojra SC 02.00.39 Kasegafochl Osaka Chwlcal 01.09.30 Mtaul Toateu Nagoya 12 13 14 FIRST VC EXPOSURE DATE OP DIAGNOSIS ACE AT DIAGNOSIS YEARS OP EXPOSURE TO DIAGNOSIS YEARS OP EXPOSURE BATE or DEATH II HISTOLOGICAL I ESTIMATED ( COMPIIHATION | EXPOSURE ( OCCUPATION | LEVEL | ___________________ l________________ 1________________ 00.04.S3 24.10.25 S3 24.IO.7S 113 ynra auto|clc | leaner 11964 (Aligned to (dltfercnc 00.It.SB 10.0R.74 37 17 00.07.85 26.04.05 20 10.OB.76 14.OB.as |Hot known 1 I fin polyaer(laatlon work (includ ing lautoclave Iclaanlng High IS years lAotoclave leleaner I I t OTHER I | OTHER CAREER | HICHLICHTS | COHrtSNTS _____ I_________ I i I (Japan Tlieo |25.10.75 A | Ja pa neat PVC I As eve IcUcii |o 1 31.0). 78 A (30.11.87 I ( I I I 1_________________ I Japanese PVC ( AaeoCI ar Ion | let (era <>t 131,03.78 6 |30.I 1.6' I (Letter froe (Dr Nakaaura, | Japaneaa PVC (Association (30.11.87 I |PVC Ataoc I says out |known I* Japan (Tlaee (Indicated Ion 25.10. 2S| wik since (exposures (had 111 (often at lhaalth (3000 ppa up) |lo 1974 | J_____ AP00055865 1 Pile 19 NORWAY IC1 CHEMICALS 4 POLYMERS LIVER Angloasrco** Catei - (Review Detei ) Jso 1969) URX/ASL 1-M1C10CASES,2fc I Il I il * 5(6 6 9 | 10 II i2 i n 14 IS I lb COUNTRY AND REFERENCE M0 NAME OR | DATE OP 1 INITIALS ( R1RTH 1 11 COMPANY 1 1 FIRST VC | FACTORY ( EXPOSURE 11 DATE OP diagnosis ACE AT D1ACN0S IS YEARS OF EXPOSURE TO DIAGNOSIS YEARS Or EXPOSURE DATE OP DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION 1 f OTHER Career HIGHLIGHTS I 1 i OTHER COMMENTS NORWAY 01 | AM 23.12,1$ Norsk Hireyt 00.0). 50 | 2 12.71 | S6 22 21 (04.01.72 Yes High I'ulnin 4 Hydra Autoclave supervisor Coitf i rsed by Or ThlleEvsnaeu of NH. At ATHC h| of June I7fl Mr P Rengne* (ted tlist AH hod been s sea her of . (art-up tees. VCH i rVC were sale In ssae building. Pie VCM w< aadr J roa> *cet y I me AP0005 Ol 00 CD Pje SWEDEN 20 ICI CHEMICALS 4 POLYMERS LIVES Angloercoe Caeee - (Review Dace: 1 Jan 1989) UPX/ASL - LANC10CASE5.25 11 1 12 1j | 11 11 COUNTRY AND 1 MANE OR 1 DATE OP 1 REFERENCE 1 INITIALS 1 Him I NO 1 1 11 1 1 SWEDEN 11 4 COMPANY 1 |S 1 1 1 | FACTORY 1 1 1 1 6 FIRST VC ttrosuiE 01 |NU 01 |L 03 INE 1 04 |AL OS (23.06.27 1 ItMiurJ jSundeall 11 1 11 1 |2?.ll.l | KcMmird |Sundavall 11 t1 11 11 1 1 \ 1 11 11 11 11 1 1 1t 11 (1 1i 1 I 1 1 11 1 11 1 110.06.10 1 Kmanord (Sunday*)1 11 11 116.11.14 I F.fnord I Sundeeall 11 I1 {( 11 11 11 11 11 ll 1 l 1 1 1 ( 1 ( 11 11 1j 1 1 1 1{ 11 112.03.19 i Keaanord (Sunday*!1 11 11 11 1 1 1 11 11 l1 1 1 J I6.0A.SI 00.01.45 00.OS.47 00.00.46 II.05.64 7 DATE OF DIAGNOSIS 20.10.70 a 00.OR.72 IS.03.76 12.05.77 22.11.SO S1 9 11 1 to 1 1 12 JJ 11 ACR AT ( YEARS or | YEARS OF | DATE OP { H1STOL0C1CAL DIAGNOSIS 1 EXPOSURE TO 1 EXPOSURE 1 DEATH 1 CONFIRMATION | DIAGNOSIS 1 1 11 11 11 1 13 1 14 J_____________ 1 ESTIMATED 1 EXPOSURE | OCCUPATION LEVEL 1 1 1 1 5 OTHER CAREER HICHLICHTS 1 1 1 1 | | 1 1 1 J 16 OTHER COMMENT 3 43 1 19 61 1 27 65 1 29 62 1 31 61 I 16 1 IB {20.10.70 I1 1 27 |16.06.72 11 11 ll 11 11 11 1 11 1 11 l 1I 1\ 11 11 1 1( 1 21 (19.03.76 11 11 I 31 112.05.77 11 11 t1 1( 11 11 1 1I 11 11 1 11 11 1 i1 1 16 122.11.60 1 11 1 11 1 11 I 11 1 11 1 11 Yea Vea Yea Tea Tea High High High IPolywrker 1 | VCN |product Ion 1 1 1 1 1 1 1 1 1 1 1 1 1 IPolyuorker 1 1 (1946-1956 Ipolyuet- Illation |worker ( 12 |yr*) A I9S6 -| 1 1977 foreaan) 1(19 yra) 1 1 1 Nigh 6 Yeara Low 10 rear* 1 1 1 1 1 1 I 1964-1970 Icenr r1fugc |oj>rAcor |I970-J960 |d rler |o pcra t o r J_____ I 1 1 (Mr SJoeM o' a lletter of 126 March |97H Icon! Iraa 6L |waa aonnaer (worker who w | l.eavlly | exposed f I ptobabl y mn |ore ao 1 Inn ja tioinal Irenctor |cleaner 1 1 1 1 1 (In lli.L 17 lyre of JeapluyuenC had (been tieav 1 ly Jrapoitd. In |I974, liver labnoraal 11 y land necros it. |d l agnuaeJ. |0ala coni 1 r mt-.l 11 n 1>| b l|lm (letter 1H.H. 7 ! | C o CEP 1C 1 1 | Let ( er ol | 2nd Nov I'iHI 11 i nai (Or Da.Ij hyt ,-n 1 1 1 In hi* W Utr o lor April |9A2, Ur Honteiano of IARC utft in Sweden'* National Hoard of os Health g vea 20-02-70 aa date ot dlArimivlas f< Cure IJI and 15-05-7/ 1 n r fj.r 1)7. ct> AP000558 P.ge 21 UK Sheet 1 LIVER ICI CHEMICALS 6 POLYMERS C*a - (Review Date; l Jan 1*83) -"I WK/ASL - LAKCIOCASES ,26 COUNTRY AMD REFERENCE MO NAME OR INITIALS DATE OP rirto 20.04.01 ICI 02 ~-------------03 |BJW 1 1 1 04 (JSR 1 1 t 1 1 1 1 i 1 1 1 1 1 (02.06.37 1 I \ { 123.06.20 1 1 1 1 1 1 1 1 1 l 1 1 1 BP ICI factory FIRST VC IUOSOU HIlthMIRR 04.04.44 DATE or DIAGNOSIS Ace AT OIACNOSIS 03.12.72 <ri 4 Collier paper aeya 23.12.72) YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOCICAL CONFIRMATION I ESTIMATED | exposure | LEVEL I ___ I occupation I I te 22 03.12.72 Ya 500 ppe 11444-7 VCM (Fos 4 |147-R Drier Collier paper 11448-61 (Autoclave aer* 23.12.72) (operator |1461-66 (Drier t-..................... - OTHER CAREER HIGHLIGHTS other COMMENTS Lee and Harry Lancet 24-06-74 page* I 3 16-0 Dubtoul {brI cat U 1 1 Barry 1 | 00.02.66 11 11 l_____________ 1 <1 |Hlllhou*( 26.04.54 1I 11 11 11 11 I1 \1 1 11 11 11 11 11 11 00.12.74 00.06.73 r 1 1 1 1 1 | 1 ) 1 1 1 1 1 1 1 ) 1 1 1 37 33 1 i1 1( 1 09 1 3*3 124.12.74 1 Yea 1 High |Autoclave ( Etpoaure 1 11 1 |c leaner ( Ilalted c a 1 1I 11 1 2,66 - 9.64 t 1 1 1 \1 11 11 2$ 1 IB 112.10.79 1 Tea 1 NetUta- |54-5 1 1 (Pre-war Tien 1 11 1 Mfh (Ragging (packer 1 11 11 1 <1 1 |Plant 11434-44 anar 1 (55-6 (vehicle 1 (Drier Plant lealntrnance 1 11 1 11 1 )56-58 liTO-sI. ' ' 1 | Autoclave (fish packer 11 1 l1 1 1 worker 1 1 154-61 1 1 11 \ 1t 1 (Qiergeharwl 1 1 (Drier I 1 11 1 (Plant 1 i 11 1 (61-72 1 1I 1 |Poreaan 1 r 11 1 |C 2/1 Plant 1 1 I I I I I I AP00055868 Page 22 1 Cl CHEMICALS 4 POt.YHEKS UK Shaat 7 1 COUNTRY AMD 8EFEREHCE HO U os 2 1---------5------- ~j-----------i--------- l NAME ok t INITIALS i Blunt | COMPANY i( i1 JK 130.03.16 > BP JJ 1 1 | FACTORY 1 1 (Barry --- s---- first vc RRF040RE 08.01.51 LIVE* tj>(liH<cciiH Caaea - (Review Date: l Jan (989) 1 M4 Vf DIAGNOSIS 00.10.79 >1 b 1 ACS AT T YEARS or DIACHOS1S | EXPOSURE TO DIAGNOSIS 1 65 I 28 tb 1--n-- i icahS OF | DATE Or exposure ( DEATH 1 1 21 1)9.11.79 TFT SZF J*3I ST 26.0i.20 Barry TRF W.ftMft' TI7T irry T5JT TOJT TZT 17 6i.oi.86~ 872 Ji.06.s6 12 HXSTOLOGICAL CONFIRMATION ypx/asl - laih;iocases,2J li i rs r i ESTIMATED i i i EXPOSURE ( OCCUPATION | LEVEL 1 1 1 (1951-52 1 | (Polyc leaner (1952-55 | Uto (1955-60 IPolyf l nor 11960-66 (Poly (CJiatgehand |1966-70 lOtarging (operator | 1970-22 (Drier (operator I ______________ ~l 1 yr (Paly Floor (Operator (5 yra ICreaaer on (Poly floor IPolyc leaner II96J-S (Recovery 11965-1971 15 OTHER career HICHLICHTS 1 1 16 om COMMENTS 08 |WTM i i i i i t i l i i i ( i I i i i t L |64 6i.ii I BP I ( ( i i ( i i i ( i r i i i i j 1 --------- (tarry 1 I 1 1 1 1 1 1 1 1 1 I 1 1 1 1 1 1 1 i 'rc.w 50 (27.11.81 i i i i i i i ( i i i i i t i t i _j_________ 1 1 1 1 1 1 ( 1 1 l I 1 1 1 1 1 1 1 ( 1 \ 1 I 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 I 1 1 1 1 1 f 57 i --n-- ( l l i ( l i t l l l i i l l ( l i i i l i i i t i i i i i t i i i i i * i i ( i i TT~ 'jH.lMl < ll tl 11 ii li ll ll li ll ii li (( ii lt li ji (i li ii l( ll _i i 11950-1*56 1500 ppm ((968-1976 (ZOO ppa 1 * 1 t ( 1 1 1 I 1 1 1 ( 1 1 1 1 1 iJTSPTi (1938-1968 j 1 Autoc (are IMotor Neclianlcl (operator (1948-1950 | (1951-1957 (Operator on | IQllcgcun lAcetylrne I lautoclave (Production I (building (Plant 1 11957 -1976 (Shift liupeivlaor | auloc lav e (building | Aever |cleaned (autoclaves 1 1 1 1 1 1 1 1 1 > 1 1 1 1 1 IbuC 1 |tupervlaor J | job tnl al lad | 1 1 1 (rnterlng liai vr laves (to Inspect 11 lira 1 1 1 1 1 1 1 1 1 1 1 AP00055869 'Me UK She 3 ICI CHEMICALS i POLYMERS LIVER Angloaarcoa Caaea - (Xevi, _7--------- ------- Date: 1 Jan |989) I It UPX/ASL - LANUIOCASES,2B 13 country and REFERENCE HO NAtC OJl INITIALS DATS OF RUTH 09 EIC? 07.05.2S 10 CJT 04.04.47 W t 11 II (CLP (06.05.26 1 IF 1 11 1 11 1 1 I 11 1 11 1 11 1 11 1 11 1 1t 1 11 1 11 1 11 1-- -- _J J_______...... 24.01.37 FACTORY Retry Rarry 1 (Rarry 1 I 1 1 1 1 1 1 1 1 t 1 1. 1 1 1 1 1 1 1 1 1 I 1 I 1 | FIRST VC EXPOSURE DATE OF OIACM0SIS ACE AT DIACHOSIS 15.02.50 27.04,66 01 05 64 37 1 19.12.65 | 02.06.83 1 < 1 t 1 1 1 1 1 l 1 1 1 1 1 1 t t 1 1 1 I t 1 1 ) ( 03.04.65 57 46 1 | 1 1 1 1 1 1 1 1 1 ( 1 1 1 YEARS OF EXPOSURE TO DIACHOSIS t 19 | l 1 i i i i i i i i i i ! YEARS OF EXPOSURE DATE OF KATM 24.02.83 4.2 16. OS. 64 11 16 |02.06 85 | I1 11 11 1i 11 11 l 11 11 t1 1 1( 1 . 1 06.|2.85 HISTOLOCTCAL CONFIRMATION ESTIMATED | I EXPOSURE | OCCUPATION | LEVEL | I OTHER 1 CAREER | HICHLICHTS { OTHER cotoenrs | Pol ytmiket I I I I I t I I I )I I 2 peers on | (Acrylonltrllr | (Realn Plant. | |Alao prior to | 11950. 4 yea re | | RAF { Inalntcnance, | |3 year* actor | (car palntahop.f |2 yeara In | (Craving Dock. | iI (I HiRl> - II | Polyc leaner | Heavy gooda | infeiaallon oncha 000)1966-67. | vehicle drlvet(given in ppa). Low-| Spray-dr lei I until (Inal 16 aontha |biK<r l967-|lline jletler | 18.06.BA 1 n- (50 ppa). 168. Med I ua - | IlM-dorn III D H J |U111 laaa 2 I aunt ha ( 200 p(-) | nrlpper 1 operator | 1968-70. I I I I I 1 1 Tea )High 1t IPolycleaner |- 1 I Letic r of 11965 -69 (fed 69-79 |Low 79-82 1 1 1 ) 1 1 1 1 1965-60. I Service (operator | | | (68-69. | (Poly (Operator (69-79. 1 | | (Leading Hindi 179-82. | )1 11 11 I Low I9 5?-59|Spare ain, High 59-74 (Lagging Lou 74-85 (Moor 1 i (04,06.81 [Or Paul Salcfi (and letter uf (04.06.85 |Or l> HO tvan. (Oeaophagr. 1 Ihaeuorrhage (due to loeaophaRe. 1 Ivartrea due i .. (Angloaen.ia.* (uf liver - --1-------------------------- ----------- I Let irr | lb.Oh.85 |Or F I Le | 1957-59. (Autoclave |Opertor I 1959-05 I _____________ 1 AP0005 Page 24 UK Sheet 4 ICI CHEMICALS 4 POLYMERS LIVE* Anglcesyco** Caaee - (Review Dete ; ! January !953> WPX/ASL2 - LAHCiltCASES , 1l 1 1 i2 | 3 | 4 11 1 11 1 COUHTRT AM) INANE OK 1 DATE OP 1 IEF1UNCS |INITIALS) 61RTH 1 COMPANY MO 11 1 1I 11 1 1 11 1 UK |MJ 102.01.46 IIP n1 1 1 1 1 1 11 1 11 1 11 1 1 |. 1 11 1 11 1 11 1 |4 |CS |11.06.42 |6F t1 11 1 11 1 11 1I 1 1 1i 11 11 1 1 1 1\ \ tierI I) 11 >23.08.2) | if 11 1 t1 11 1 1 11 1 1 1 i1 ( i1 1 u |ST 121.01,22 1 ICI 11 11 11 11 1 1 1 1 1 1 _L_____ _ 1 1 1 J_ _ 1> ( III <11 III III 11 | 5 16 1 I7 1 19 11 ( 10 ( 11 I (12 11 1 13 1 14 i 1 15 1 1 16 111 11 1 1 111 (TEAKS Of | (HJSTD- 1 1 1 (FIRST VC (DATE OP (ACE AT (EXPOSURE (TEAKS 0F| DATE OP (LOCICAL (ESTIMATED! | PACTOUT (EXPOSURE |014CNOSIS| DIAGNOSIS) TO |EXPOSURE) DEATH |COHF1RH-(EXPOSURE | OCCUPATION 1 1 1 | OTHER CAREER 1 1 1 | OTHER COWlfHTS 1 11 1 1 11 1 1 (DIAGNOSIS! | IATION (LEVEL 1 I 11 I 1 1 11 1 1 1 1 H1CHL1CHTS 1 11 1( I (tarry 1 1 1968 1 ( Jan 66 1 37 1 18 11 ( 1 3 102.06.66 | Yea 1 H*Rh 1 Polyc leaner 1 |Moved to 1 (Reaalned well, working 111 11 1 !1 1 1( 1 11 1 1 1 111 1 1 1( | 1968-69 1 Acrylonltri le (actively, until Jan 1944 1 1 1 | Low (Cencral (Plant until 1 1 1 1 1 1 Depot (left Rp 19*3. 1 1 1 11 | 1969-70 IManagcr of 1 1 1 1 | High |Poly 1loot 1IC 4 SS Ltd at | 1 1 11 |1970-1971 ICatdlff Airport) 1 1 11 1 I 1961-86 1 1 1 |tarry ) 1 1 1 1 1 1 1 I 1 (terry I 1 I 1 1 1 11 11 107.07.66 (27.08.67 11 11 11 11 11 11 11 11 1 11956 1 1 11988 11 11 1( 11 11 I1 1 1 41 I 21 1 1 1 ( 1 1 1 1 1 1 66 1 32 1 1 1 1 1 1 1 1J i ... 1 1 1 (i 1 1 1 11 101.12.86 t Yea 110 ontha) Polyc leaner 1 (Letter! froa Dr OHC Evana, 1 1 (High | 1966-67 1 ( Pathologlae , Penarth, Hales 1 1 110 year* |Polyfloor J land Or QMJ Hllltaai, P, tarry 1 I (conatent (Hotter at tiaee| 1 1 (Nadlua (between l 1 | I t Ituc oo 11968-1942 ( 1 1 ( linear- 1 1 1 1 1 lalttcnt 1 ( 1 1 (Jo*a ( 1 1 f1 1 1 1 11 1 1 ( 16 | 01.03.881 Yea (9 ya ra (Poly cleaner 6 ) 1 1 |7n7orajtlon Ifoh 1 1 1 Nlh (Operator |Dr OHJ Hllllaaa. IP, and 1 1 |5 year* |61ow 6 Recovery).,...,,,,, (Or Paul Satth. ParfroJo* 1Jt 1944 1 1 | (fcdiua | Operator Mnterad t ent > 1 1 12 y*ar I Ut111 y ) 1 1 1 1 Low (Operator ) 1 1 11 l (1 .................- 11 IHUlhouBc) 1963 11 1( 11 11 1 1(988 1 1 1 1 \ 1 11 ( 66 1 23 1? I 12.11.681 Tea 1 > peer ) ( 1 1 I Low ) ( 1 1 1 |4 ycara) ( 1 J 1 1 High ) 1 1 11 1 (2 ycara) (Operator 1 ( 1 1 (Hepatic fI6rt>al* 1974 (OeeophageaJ v.ruea^ Iforta-caval hvftt 19/j j (Jn/oraation 7r< Or temi.-i ( , MCI, and Dr f 1 Lee, aleck,.,.,,| I11 I11 i <1 I i 1 (Ylctoda HoapUal J9B4. I 11 1 i t 1 I 1 1 1 11 11 { 1> 11 11 11 1 I I 11 11 1 1 1 1 11 11 1 1 1 1 11 11 1 11 1' 11 11 1 1 1 11 11 1 11 AP00055871 P<l* USA Sheet i 25 ICI CHEMICALS l POLYMERS LIVES Aagtoearcoee Caree - (Review Date; | Jen 1989) HE ifitn of dalem DAY - MONTH - YEAR 1 11 COUNTRY AND ( KANE OR | DATS OP 1 REFERENCE | INITIALS | BIRTH 1 COMPANY 11 1 i FIRST VC | FACTORY | EXPOSURE DATE Or DIAGNOSIS Ace AT DIAGNOSIS TEARS Of EXPOSURE TO T YEARS OF DATE OF EXPOSURE DEATH HISTOLOGICAL CONFIRMATION ESTIHATEO 1 | EXFOSOBE | OCCUPATION | OTHER CAREER l | .| OTHER COHHfcNTS NO t 11 11 D1ACHDS1S LEVEL | HICHLICHTS | L L 1 ----------------------L L X X X X XX X 1_________________ t 1 I IHIilurji given | tolling Slone Earl 17.10.23 UwU- Q9.l2.6R 03.03.7J 03.03.73 (in Annala Nt (Art Pot Cleaner (ACAD SCIENCES (ef l N'T Acad Park* iUU (lock Jmi (Vol 329 (|979)(of Sc Syp 19?*) p 33 |page 190 in 1197* |Paper by (Alao Hock |t R Cot tine oflJewa 1.7. 7A |0SHA |p 5) I9.0S.33 RFC LaulatllU IS.ll.S5 00.03.70 27.09.71 (MtOSH 28.09.71) I Pot Cleaner 1 (Cf Block) | I iRef I lAlao Hack (JAMA 1.7.7* IP S3 Edward 2S.0S.IS Dinwiddle Lou lavUle 28.II.*3 19.12.73 1 0* 1 11 IIS.01.24 | RPC 1 |Louta- 11 1 1 06.07.52 1 19.00.67 1 13 1 11 | vllle ( 1 1 1 1 OS ) P1 11 125.01.12 f RFC \ 1 |Loula- _!___ 11 1 I 19.06.66 | 09.06.66 t 52 1 11 I villa 1 1 ) ! P1 1 1I 06 |8*f 123.11.28 | RFC I AuicIn 1 1 I Jo neat 1 1 1 11 1 1 | Loot** ( villa 1 1 1 11 t 17.01.62 { 00.07.76 (1 11 11 I 1 1 l 1 I 65 1 11 I( ( t 1 11 11 1 _11_________________ _____ 1 _J 1 i_ . 1 l 07 )hirle* 03.05.22 T Saart S CJiarle- 27.08.** a ton 00.00.68 1 OB | 1 1 1 I 11 1 |06.OS 20 | Goodyear |Nlagera 1I 1 1( 1 1 - t. --- 1 1 ( _J 11 1 07.10.46 | 00.08.61 11 11 11 (1 1 1 1 1 1 1 *1 1 | 1 1 1 ! IS 20 12 is 19.12.73 1 11 1 13 107.01.68 | I 1t 1 11 1 1( 1 20 (09.06.6* | 1 11 1 11 1 1( 1 12 126.07.75 I 1 1t 1 11 1 11 1| 1 11 11 23.03.68 1 11 I 15 |29.08.61 1 1 )1 1 /1 1 tl 1 11 T* Yea Yaa Yea 1 I I 1 | 1 1 I 1 1 1 | 1 1 I 1 I Pot Cleaner (Loulavtlle (Cl Block) (Courier | Journal 07-09-80 11 IFot Cleaner 1 )(Cf Block) | |Pot Cleaner | |(Cf Block) | 11 11 IDS Air Force| (Pol Cleaner | | < Cf Block) | 11 11 IRef I |Alao Hock. 1 IRef I |Alao Block 1 1 IRef 1 (Alao Block 1 1 liter i < rloulavil 1 e /TlMft 2). ) ?5 (Ret Ired Apt 1 I (197* fAleo Hook t_________ _ I I Itef I 11 1 ! :1 1 1 1 . 1- AP00055872 *'* 26 USA Sheet 2 ICI CHEMICALS 6 POLYMERS LIVER Angloaarcoea Caiea - (Review tote; 1 Jan 1989} UK intern ol daces DAY - MOUTH - YEAR COUNTRY AMO REFERENCE HO NAME OR INITIALS DATE OF BIRTH 09 Raymond 08.11.31 Cettle- Flngetf Goodyear Coodyear Princli A 17,11.18 lachwn FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS Loulelllt 21.05.45 01.03.74 Niagara 12.0fe.5t 00.03.68 Niagara Pottatown 13.07.49 Pd 02.05.69 ACC AT OIACM3SIS YEARS OF EXPOSURE TO DIAGNOSIS 29 YEARS OF EXPOSURE OATS OF DEATH 11.03.75 10.05.6S HfSTOtOCICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL 2000 pp 16 _L I | OCCUPATION I OTHER CAREER I | OTHER \ COMMENTS | HIGHLIGHTS ,| _____ ___________ f____________________ I_______________ . 1 1 I (Ref I haa I wrong tlgui lie Ifrtr leapoeure. | Lvulavll le | 7 lac a | 29.10.7*. H2.J.7S. I 10.3.76 !______________ ,, I I He/ I High 10 yr I (ef I 10 yr ai I lUtlllty t reactor ap. (Service op. (not cleaner|Bagger - aeparate (Dryer op. crew cleaned) Stripping of. J_____ _ I | Ref 1 let vi (of 76 Apr f 1 IJ978 /roe (Ruaecll A Perk |co J T leave? I i aucoclavea) |3 yt prior lf MCA (acrvlce In f | eyre plan* 1 13 RUhtrd 01.12.21 Edward Clangenln S Charle ston 07.04.74 2000 ppe fOiar Jeaiun |Dally Mai 1 171.7-75 I (Never dlag- |noaed aa alll< , lloaarvoea ,,g (liver. In(,,lre, (al Ion given j {lettet j2 M II9H4 fto> IJ A 5a I g I I JAccoui IASI. - Idvurc Vl n V AP00055873 Peg 27 USA Sheet 1 IC( CHEMICALS 4 POLYMERS LIVER taflMircoM Caaea - (Review Clete: I Jan 1989) UK Syates of datea DAT - MONTH ~ TEAR WVXMSL_2 - I -MU' lOCASLb, 7 COUNTRY AMD REFERENCE HO NAME OR INITIALS DATE OF nm FACTORY FIRST VC EXPOSURE DATE OF OIACMOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF MATH HISTOLOCICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HlCHMCHTS OTHLR COMMENTS USA Jaaea Howard 04.11.27 Louii- OR.OS.SO 00.00.49 17 Fcercnbooa 06.05.31 FC Loula llle 23.06.55 II.10.74 19 Charlie 22.04.28 Arthur Avon Lake 15.09.54 00.00.75 Virgil Qirlatlan S Cbarle- 00.00.43 aten 19.06.75 31.08.17 Goodyear Niagara 00.00.55 30.04.76 Cheater Hinkle 5 Charle- OO.12,46 aten Early 77 27.03.69 1951-4 VCH polytlaalloft Froa 1954 |Table 4 In onwarda In jUagoner A ray and ocher ITcatlaony to aervlce. IUS Senate 46-50 Aray |Conflred In |M N Johmon |Ur 07.06. ;a 16.10.80 Yea on 11.10.74 but no peat-aortas 16.10.90 |Or M K Jatuuon (letter ol |24.2.1 rn.i| f | need dee 11> |b yemra ( ter Id lagnoa le_______ 02.tl.75 06.04.76 13 yra awtocleane 8 yra on Eatol pi aatlclae 4 Carboaet operacIon Navy Tyre Set 2000 ppm iConttrved In lH H Juhnaun (I c r 07.09. 78 (Alio Roll! a* |Ston Mg. IJ5.OI.76 I J___________ I ) Ut J I l ai po r | Sun |2I June 1975 | Char l * t on 10.1 If Hell 121.7.75 1 | N I OSH lef L L. i |of 2$.IU.7`7 J_________ __ I |28 yra wj11 (UCC at *jc (getI red I News rein.., |? 1.7. 77 I AP00055874 R* ISA Ihect A 29 1CI CHEHICALS i PGLYHCRS LIVE* fngluiirciiM Caaea - (Review bate: 1 Jan 19(9) UK ayatea of dace* OAT - MONTH - TEAR NVX/ASV-_2 - LAW.1UCASKU. 1 11 1 |2 |3 11 1 1316 | 7 a i 1i 1i l 1 9 1 10 1 11 1 12 1 13 | 14 ( is 1 lb t1 11 1 1 11 11 1 1 1 COUNTRY AND | HAKE OR | PATE OF 11 1 1 1l 11 < I FIRST VC 1 DATE OF ACE AT YEARS OF ( YEARS OF 1 DATE OF | HISTOLOGICAL < ESTIMATED ( 1 | OTHER 1 1 UTHMt REFERENCE | INITIALS | IIKTH company | FACTO** | EXPOSURE | DIAGNOSIS DIAGNOSIS EXPOSURE TO | EXPOSURE ( DEATH | COMF1CHAT ION | EXPOSURE ( OCCUPATION | CAREER | CUMHEHTS NO 1 1 11 1 DIAGNOSIS l 1( | LEVEL 1 | HIGHLIGHTS r USA 1 1 1 1 1 1I 1 1 1 1 t1 1 1 1) 11 1 1 i i 22 1 1 102.10.23 1 RFC i 1 (villa | I ll.07.A7 t 00.01.76 11 52 t 29 1 26 104.12.?^ I i i1 Tea 1 l l ( 1 1 J Lout tvi 1 le |Tlae* 2b. 1. ?h )i 1i 1i \i I 11 11 l1 1 ) 1 1 i i( i i1 i i1 i i1 11 11 11 11 1 1 1 1 |Bald he ua> (the (Otb S (vlctla at |Sel la Lane oi 1i 1i 1 1i i 1i 1i 1i )i 1i 1i 1i 1( 11 11 11 I1 1 11 11 11 I1 11 11 11 I1 1 1 1 1 1 1 1 1 1 1 1 1 i i( i i1 i1 i >1 i i1 i i1 i i( ) i) i i1 i it i t i ii i i1 tl 11 11 lI 11 1( 11 11 ( 1J 11 11 11 1 1 1 1 1 1 1 1 ( ( 1 1 1 |whoa S had Idled by (26.1.74 | In hie Ittltl (Of |b.U9.81 |Dt K N Joha a on (conflnea ihle |1 the |caee described jby D*nnih?r (Taaburro 1 Vaa (In Feb I960 (A* J fk-dlcliu* t 23 I too.6A.ii 1 Great J______ 1 1 |Flt.chburg| 08.09.54 1 06.04.73 SO j i( 1 IS ( >4 (06.04.73 1 Yea l 1 1 1 ( 1 VoL 70 p280 1 11 letdcm (Maaa. 1 1 t 11 11 1 1 11 Qievlcal 1 1 1 1 Coacanv H lUiarlea IJ7ToS,17 Iktt |S* Oiarla 1 1759 "| 27.o5.7J Ml 1 11 11 1 "hrffrrr 1 1 44 i 'W JQ)1 iQ|lcr IHedlua to | 1941-65 non waa l 1 IN M Wheeler 1 Eduard Ifoorc I 1 1 1 ) aton 1 l l i 1 1 ) lOrlosN (aaya 267 t t j > Jrcoa 1 (I Kaalnakl 1 26/2/79) (high tor 124 yra 1 (advent (off and on Ivlnrl cealn 11abourec (unit and | 1939-4! may 11et t er of 110.6.77 to |J 5tat 1 ord 11 11 1l 1l < 1 ( 1 t i1 I |d [ppera Ion (have been ialvca beta I. 1 Ivlnyl realaa(eipoaed aa |Roae Kaalnabl 11 1l 1 1 i1 1 (unit f(rat |reac tor lleltet ol (25) 1 1 1 1 1 1 1 1 1 J 1 1 1 i 1 1 1 11 1 1 I 1l 1 1 1) 1 1 1 1 1i 1 1 1 Il 1 1 1 1i 1 1 1 ll 1 l 1 1l 1 t 1 1( 1 1 t JJ 1 1 1 (i 1 1 1 1l 1 1 11 ( 1 1i 1 1 i Removal fro* register con Iraed in R Kinafc| let tec of 5 November I9BI) 1 1 )1 1 l i1 i1 t1 j1 i1 j1 i1 i1 i1 i1 i1 i1 1 i1 i1 i1 1 (aa f Itter (cleaner (26/2/ 19 1 (helper, the | 1943 beca*e | R (Caalnahi 1 tahlfl (ehllt fitter |<5 Nov nsui ( (utility aan ((946 becaae laugReats tli.tt 11 lehtfl utility (NJ0SM *11 1 11 (aan (retain n 11 (2b.04.65 If r*t Btr ilwn 11 1( (eapioyaent va t|(Ms Iieojilnna (terelnated (ay hr faa.it 1 - (aied wl t It a:;i . 1 | R N Vliee 1 j 11 el 1vi "1 | 20/27 79 11 1 1 ( 1 ( K.nnl il'.k 1 (lellt-m "1 (lb/7/74 nii.l 11 J1J J i{ l1 1 |`./ 1 1 /mi AP00055875 Page 29 USA Sheet S ICI CHEMICALS i POLYMERS LIVER Angiosarcoma Case* - (Review Dele; I Jen 1989) UK lyila of date* DAY - MONTH * YEAR WVX/ASL 1 - LKHCTULAStS ,* 11 1 I2 |3 Il COUNTRY AM | NAME 01 | DATE OF REFERENCE | INITIALS | IRIK NO USA 1 | 1 t1 26 Mohr. lerrYl07.07.23 11 11 11 11 11 11 11 1( 11 )1 11 1 1 t 27 |J L 1 1 | <11.03.16 IIsrrtic 1 1 1 11 1< 1< i& |\ llOi.tJ 1 1 29 1 < |12.10.07 1 1 1 30 | WH 1 1 <22.07,22 11 11 t1 1I < 11 31 1 1 1 1 1 1 1 1 l i 1 1 1 108.11.23 < 1 1 1 1 1 1 1 1 1 1 1 i 4 COMPANY RFC ( VCC Vtt VCC Tanneco Cheat eala ucc 11 1 16 ii 1 1 FIRST VC I FACTORY | EXPOSURE 1( 11 1 lUxitn- IvlUt 1 | 01.10.47 | 11 1 11 <1 11 11 11 11 11 11 1i I1 11 IS Chexle-J ci.oJ.ri 1 aton | 11 11 11 11 11 7 DATE OF DIAGNOSIS 00.00.77 (up ta 2 Yra after death) lo.i77>~ |S Chari*-) 00.08.44 I ( I 11 IS Chari*-} 00,03.4i 1 area | 11 03.11.78 00.03.80 | fletlnicoo 11.06.44 i< i< <i ii i< ii <i |S a.arle-1 | eton l 12,03.46 1I 11 11 11 I1 <1 11 11 11 "30.iiT#o" 01.08.81 11 11 11 | 8 ACE AT DIAGNOSIS 52 (death) 4i 41 >2 58 57 9 YEARS OF EXPOSURE TO DIAGNOSIS 28 (death) JJ 34 44 ----------- n----------- )5 11 ( to < i | t | YEARS OF | DATE OK | | EXPOSURE | DEATH | 11 11 11 | IS lll.02.7S 1 1l 11 11 11 11 11 11 11 i1 11 11 11 11 1 iii (25.kl.78 IIMIOSH 1 27 land C < (Dal1Y NalL| <25) 1 11 1 1 44 103.11.78 1 11 1 11 |6l.o4.s6 I 1i 11 l I* |30.12.80 1 i1 l1 i1 i1 i1 11 i1 i li |02.04.82 1 i1 11 1< i1 i1 i1 1( t1 l1 l1 l1 11 11 1 1! i1 1 12 < u 1 U 1 H1STOLOGICAL | ESTIMATED | i | CONFIRMATION | EXPOSURE | OCCUPATION | 1 LEVEL I | I l 15 1 lb 1 OTHER | OTHER CAREER | CCHMEATS H1CHL1CHT5 _l____________________ ) I1 1 Tea (Exposed In (Various Jobs) (c** degree)In PVC | 1 |R KulniM | letter of |(o 22 Iplanca from ( Ichealcala (cold ruoa io| (26/2/79 and (Prof. Tea bo r ro |but Min (paste l (letter ol Yea Yea Yea Yes lexpoaure (recovery tu 1 (9/1/79 |vaa to VCH (PVC charglng| Iprobably loperacor te | 1 Ihlgh (paste ( i 1 (charging. | l 1 |IU August | | | 1 1965. 1 l 1 (Terminated 1 i 1 (employment | i 1 Man 1966 | t __________ 1 High (Operator to (Expoaure In |R N Wheeler 1 t 10.10.76 (bulk and jltr at 4 J*n 1| 1| |1 11 1 11 11 (dispersion PVC| 1979 and (manufacture 1 Charleston 1 (Dal If Hal 1 1 | 30.1 1. 78 and 1 (R Kaainrkl 1 126/2/79 1 ( Kaalnfkl 11 1 (letter of 1 11 1 11 1 1 1 1 16/4/79 |R Ksslnalti (Lercara ol |I9th June 1900 14 Srh Nov I9HD |6 - Unknown|Halncenance 1 ( |9 - Hinlaal|Hechanlc | 1 1 (6 yr* 1 1 ICIeewherc 1 fll fra 1 (Bol ler house) 1 (Operator | 1 1 1 1 1 >< Yea 1 (High (but (Cheatca 1 (aot aa high (Operator (as reactor (charge |c leaner | would (reactor | 1 (Proa 1959 to (Dr Dace> In 11976 Allphatl c| let ter (Cheat cal a ||b.10.81 and (operator arid |Jt N Wirl.-l ||roa July |976llctter <'l (experience) 1 (Worked aa | (labourer 1 (fr ( (June 1941 1 Ho date (Foreasn | a ) 1 phat 1 c (Cheat cal |Operc!ur> (9.11.81. |Alao Ur (1.., . ) |let ter <.{ (07.03. HI re {dare >il (to Mar I9*b| (and aay 1 1 1 1 (have 1 | c 1 earn'd 1 (r.-artoru |,,( , ( 1 1 t AP00055876 Page usa Sheet 6 w ICi L`UhH|CAl.S POLYMERS LIVER Anglaaarcoias Cases - (Review date: l Jan 1989) VIK system of dales BAY - MONTH - YEAR WX7AS\ I - LAHClOCAiT S.S 1 |7 1 J ( COUNTRY AHO | REFERENCE | NO 1 NAME OR INITIALS DATE Of tIRTti 1 1 32 (C W Cl row* 22-02-09 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 33 JS Fergon 09-10-27 I Jnr 1 1 1 J 1 34 |Hr fcyrua 29-01-34 1 1 1 1 1 J 1 35 1 1 1 1 09-03-12 J 1 36 1 1 1 27-08-32 1 1 1 1 1 1 1 4 COMPANY Monsanto 11 151 6 I1 11 1 1 FIRST VC | FACTORY | EXPOSURE 11 1J 11 Sprlngflaid 1 Mass | 15-10-51 !1 1i 11 11 11 11 11 11 1i 11 11 1( 11 11 11 11 11 BFC (Louisville 09-09-54 11 11 11 1l RFC 11 11 |Louisville 1955 11 11 !1 11 11 DCC 1) 11 IS ttsrle-t 1st on | 23-07-4* 11 11 11 11 The General|Ashtsbuls( Tire and 1 1 Rubber Co 1 1 11 1-06-56 11 11 11 11 11 I DATE OF DIACMOSIS 00-07-79 i1-05-82 03-11-92 18-07-93 21-08-83 ACE AT DIAGNOSIS 71 5* *8 71 50 9 YEARS OF EXPOSURE TO DIAGNOSIS 29 28 27 39 27 10 YF.ARS OF EXPOSURE 1* (In PVC autoclave ares) 28 10 1* 27 11 DATE OF DEATH 17-05-80 Alive 06.08.93 18-07-61 Alive 1( 1 12 1 n I 1* \5 1 16 l1 1 i1 HISTOLOGICAL | ESTIMATED 1 CONFIRMATION | EXPOSURE | OCCUPATION OrHbR CAREER | | UTIIKH l CdflHtfH* | LEVEL 1 HIGHLIGHTS l An autopsy 1 1 |Thc death 1 1 11940-1951 1 | | 11* f c>emA 11 was dune and Icerl If lcatel Various Jobs) (given In 1 Mediate Igave (In polyisei (letter ol 2A cause of |Hr Clrous1 |iinufactur* (February |9fcJ2 death given (usual [BUTVAl |lioa Ur (occupat Ion |LUSTRE* lUalier C 'AnfloRircoM | aa *kettle|I95I-196A I Rarnea ol (opeftLor* (Various |ob*| |Hon*ini o tin {In and | Spr lugf If Id < ("chemicals laround PVC {Or A Hunu ul |Indust ry". (autoclaves (Monsanto 1 11964-1973 1 | Vtrlout (Europe. ( 1 (clerical ( (Jobs In PVC 1 1 1 (polymerlasdon ( 1 (facility/ ( l | Retired 1 101-03-73. 1 1 1 Yea 1 |HultIp 1 e ( 1 Prof Tsjsbm > < | (jobs (letter ol 1 (Including | 12 Aug 1982 i ( (Pely |Da H N Julius,,,, 1 (Operator (Inter ol 1 1 Po lyc leaner 1 28 Feb (9H 1. 1( 1 Yea (Poly |1965 left RFC 1 Dr K N Jvhiiouii 1 (Operator 1 to be coac s 11et t f r of 1 |Au(oclave |Clergyman. |1 Nov 1982. l (Cleaner | 26 Feh 19U1 I 1(955-65. 11 land 9 Aug 1I9B4. 11 1 11 lea | High f ram 1 (194* to 1 11955. 1 1 | Dr Durey lift tor at | 5 h-pl 1 9h ; |H*dliai 1 run | 1 11955- me 1 Tea 1 (Muderate 1 1 1 1 1 1 11956-56 ) ]abouter (1956 57 (plod litrlptr | 1957- 70 | *ppr ra t or 1 i H V Lju.ldi I, | 1 el 1 el III 11 2 Sept |If [spill t I'll VI | Mr ft 1 Cd l | May IVB). ; 1 I197H-75 (li-il In* 1 |c Irrl rlil .< 1 | | V?5-(.| i-m-.iI 11 i( 1M.1I I'lttl 1 | .1 (! I 11 >> 1 AP00055877 P-B* }( USA Sheet 7 ICt CHEMICALS & POLYMERS LlVEf MxIomccom Caaea - (Review Data. I January 1969) tlPX/AM.2 * UK. ayvleii of dice* DAY - MONTH - TtAR 1l 1 2 1 5| A 1 1I COUNTRY ANO IHAHC ON 1 DATE OFI REFERENCE NO (INITIALS! alHTH 1 COMPANY (1 USA 57 1 1 |Hr J 1 1 129.08.291 an; I Peyton l 1 l 1 l 1 1I 11 1i (l 1 i J (JWR l t |2B.08.22|Alr 1 | (Product* 11 11 11 11 11 11 1 1 11 1( 1* I1 J1 51 59 l-l N**l|2).W,lt|Pantui>t* 1t 11 1t 11 11 11 1 1l 11 11 11 11 1< 11 11 (1 11 11 1I 1l 11 11 1 I5 1 1 ( i Facto** i 1 i | Louie(villa l 1 1 1 1 1 1 1 i (Calvert (City 1 1 ( 1 1 1 ( 1 J 1 1 1 I |Paeeefc 1 ( 1 1 I 1 1 r i i ( i i i i i i i i i r i ( i6 ( (FIRST VC irxposube l | l (955 i r 1 i > i i 1 i (00 .02.65 i ( i ( ( i ( ( i i l < I ( ( I960 ( t t i i i i i l i i i i i i t i i i i 1 |7 1 8 19 11 10 1 11 j 1 |DATE OF | ACC AT i1 (YEARS OF t (EXPOSURE |YEARS (>F| DATE OF 1 DIAGNOSIS!DIACNOSIS|TO tEXPOSURE) DEATH 1 (DIAGNOSIS! 1 1 1 (06.08.86 JL 1 1( 56 1 31 ( 22 106.08.86 1 1 (1 1 ( 1 ( 11 1 1 ( > 11 1 1 11 1 11 1 1 1 (19.01.96 1 1 61 ( 20 1 1 20 128.10.83 1 11 1 11 1 l (1 1 11 1 11 l 11 l 1 i 1l 1 (1 1 11 ( J (1 1 (March J 1 65 ( 26 1 1 23 129.06.86 11986 ( 1 1 (1 1 (1 1 11 1 l1 1 (1 1 (t 1 11 l 11 1 11 1 l1 ( 11 1 11 ( I1 1 1I 1 1 I l1 l 1I l I1 l 11 1 *1 1 I1 4 il ( i1 i i i) (16 1 15 1 <6 il ( 1 ttltSTO- 1 l 11 (LOGICAL 1 ESTIMATED! (OTHER 1 1 CONFIRM-1 EXPOSURE (OCCUPATION |CAREER 1 IAT10N (LEVEL | |HICHL1CHTS) other Comments 1 1 1 Yee 1 ( 1 1 1 1 1 1 ( ( 1 1 1 1 1 1 J 1 ( Wh 11 1 (Worked 1 | |regularly | |In PVC atca| |In the | |erly deyi | |MI ft | (reactor | 1 e teener ( 11953-75. | 1 1 (Information given In letter 09.08.fti |fran Dr N N Johnton 1 1 1 1 l 1 i 11 ( 1 i( 1 J t I High |Noreel | i |l963-t962|pre(reeslcn| (1 | i roft heIper| (1 (to *nlar | (1 (operator. | i1 (cleaned | i1 (rcactota, | l1 (atrlpplng | (( (end | l (recovery | (I (arena a* ( l( (well aa | l1 (charging | (1 (operator. 1 1 (Throabo cytopenl* and leukopenia l"te laince 1978. Cold treataent Cor irttirltla (1976. Under Or'a care about 6 aontbt |btfur death, had paned rnd*rd jihyvlcal |eaaainaclon 3 aoruhi earlier. J (err (letlera of 22.10.86 and 23.01.05. ( 1 1 1 \ 1 1 1 1 l1 1 1 l1 1 t (Never in huapltal for any chronic or 1 Te* | Low 129.09.60 - (Worked laruta medical probleaa. Oeaefi crttIHi-.if (1 (Hay 66 |belsic latatea cauae of death cardlo-pul aumty 1 (Vinyl (I960 (arraat aecondary to angloaarcoma ol 11 (Fabrlcet loot wl th US 11 Ivcr. 11 |Plant |Alr (Letter of I5-U7.86 frea John E Ertel r 1 lh (May 66 - (Force. |of Pantatote with letter of 26.02.86 i1 (Aug 7D (United (from Dr Auerbach, Pathologist. i1 (Utility (Wool 1 i1 (ftealn (Dyera 1 i) (Operator (and 1 i( il i1 | (Inc Jul b6| DA aril t e 1- Sep 67 IRractor | | 11 Xx i1 (Uperacor) | t I Low tSap 70-82 l 1 1 i1 (Monoeer I 1 rI (Operator | ) | LOW | IYS2-H ^ | 1 1 i> ii (Mill 1 I CJper at or , | 1 1 ii (Calendar | 1 ii Ji (Shop, until! ( rel 1 reeetit f 1 1 1i 1 I AP00055878 rs> )2 USA fik* a 1C1 CHEMICALS 6 POLYMERS LIVER Angioaarcoma tuci - (Review Date: I January 1989) UP1/ASL2 - LAHCloCAShS. 7 UK syC* of datea DAY - NORTH - YEAR I 12 f 3| 4 1 5 |6 | 7|0 10 | II I I 13 I I 14 I | 15 16 1 1111____ ____ _1____ _1_____________ 1]1111__________ _________ 1t1 1i 1 (YEARS OF 1 1 IHISTO- 1 1 couwrtr AMO 1 NAME OR 1 DATE OFI 1 irifcsr vc DATE OF | ACE AT IEIPOSURB | YEARS 0F| OATE OF | LOCICAL IESTINATEOI REFERENCE |INITIALS! RIRIJI | COMPANY 1 FACTORY (EXPOSURE DIAGNOSIS! DIAGNOSIS) TO lUfOSURE) DEATH icoNFiRM-iurosuRe ioccupation NO 11 1 11 1 IDIACNOSIS) | IATIOM IUVIL | USA ii 11 1 1 1 i1 11 J___ ______ 1 _______ 1________ 1 1 11 1 > 1 1 1 40 l p p i 4.10.14) arc (Ltxjta- t22.OS.42 1987 1 72 1 45 1 34 103.01.87 1 Yea ) High |Ch**ical ICItaer | 1 |*llle 1 1 1 1 1 1 |1942-1974)Worker 1 11 11 1 1 11 1f 11942-4$ 1 1 (OTHER | CAREER 1 1 | _ OTHER COMMENTS | N JCHLICHTS'I 11 r1 i (Letter fro* Dr Olcte, BVC, 1 110.3.87 i1 11 1t 1 1 1 1 11 11 )1 1 1 1 1 1 1 Lo 1 i < 1 11 1 |1975-1974)Foraan i 1 1 11 1| 11945-76 i 1 1 1 1( 1 t 1 11 i1 1 i1 1 1 11 41 |R Ruck ley 2.02.15) iosdyear INlagara 1 1940 1 11 (Falla 1 1 11 11 1i! 11 1 11 11 1 11 11 1 11 rI 1 11 ii 1 11 iI 1 11 1 1 1967 1 72 1 11 11 1 1 36 I 27 120.08.67 I Yea | High 11949-6$ i1 | Retired (Letter* fro* Frol Tamborio 1 1 1) 1| (Chemical Op/ 1977 (Unlverally o! Loulavllle, 1967 1 I 1 1 1 | | Shi f Sup/ 1 (AR 62) land Dr C A Johnson, Goodyear. I 966 1 1 11 11 iFoieawn, 1 1 1 I 11 1| |FVC Realn 1 1 1 1 1 1 1 1 |Production 1 t 1 i1 1 | Madlia 11963-77 1 1 1 t 11 11 INF Plane 1 1 1 1 11 1 IlLefc PVC area lor 6 one ha 1 1 1 1 1 1 1 In 19651 11 X AP00055879 Page 33 YUGOSLAVIA ICI CHEMICALS k FULTHEKS LIVER Angloaercee* Caaea - (teylev Pate.- I Jn i?) OTK/ASL - LANCtUCAStX. 1 1 1 12 I 1 1 couvrer and imam o* i xepensHCK iinitials! HO | YUGOSLAVIA 1 1 1 31 1 1 DATE Of! NINTH | 1 ( i i 1 5|6 | 7 a 1 . 10 1 11 1 11 | TEAMS Or 1 IFIUT VC|OATS or ACE AT iurosuite TEAKS OF CCKPANT | rACTOT|UPCSU*NlDIAGNOSIS DIAGNOSIS! TO EXPOSIMS 1 11 (DIAGNOSIS l 11 1 I1 1 1 t1 1 11 DATE OF MATH 12 | 3| 14 1 >3 1 1 llt&fc- | I 1 LOGICAL | ESTIMATED! C0MP1RH-I UPOSUKE (OCCUPATIO* 1 1 lOIHEK ICAMEK 1 1 1 1 ATION | LEVEL | IHICMUCHTS) 1i 11 J___ 1 1 11 16 OTHEK COMMENTS 01 | 1 1 1 1 02 | 1 1 1 t 05.04.I4|jufc IVintI 1 1 15.11.311 Ju* (Vlnll 1 1 t |split 1 1 1 1 |SpUt 1 1 1 1 (00.00.3 3101.04,7) 11 11 11 I1 100.00,S0| 12.07,73 11 11 1l 11 5 I 1 t 1 A2 1 1 l 1 1 20 23 20 OS.04.73 Ift 12.07.73 Yet | ( i t Tea* | 1 1 1 1 t 1 1 1 l | VCH ! Plroduc t Inn 1 1 1 (SAJUC ci *1 pper | Eny Health Perepectlvc Vo I 17. (PP 189-192 1976 1 1 |*ln hi* letter of 3 Oct 197ft. Dr Splriei of | NIOSH chanced Che atetui of Caae 02 (o VCH (production employee. Dr Splrla* alee (notified a new Caae 0) a 1 ao a VCH production | worker. 03 1 | i 04 ( 1 121.12 31 IJuge 1 |VI all 11 11 111.06 301J40 1 IVlnll ISpill 1 (Split | |0A.06.54| 1 1.01.76 | III1 III1 1 11 | |5.12.50(03.09.76 ( ( t1 45 1 1 | T 48 1 1 22 20 22 (11.01.76 | Tea* | 111 111 111 18 103.09.78 | T I 111 IVCH (Production 1 1 1 1 1 1 1 1 1 1 1 1 1 1 (loae Kaoinekl letter of 19 June 1980 i.d (lAKC letter of 1 April 1962 AP00055880 r In c id e n c e o f ASL Cases Per Annum E 0 u w CO *0 n o c cm c CQ CO (0 rH eo u 4) e 'tH O CD o 01 o 0] o-*ooo--'ONOa-^fiNnflteiA--<0'0^oi/iON>ciAn 'JIn Pi >k*l pH ccj v4 CO 4) O T3 3 X> u H 3 CN Q> CO p) o u o .G 3 C O yj o r-- 3 3 an c 4) M-- pH CO 3 a u pH J5 cw fl o tH a/ 1u TJ o 3 pH 3 H pH pH j_j U Co c u tH U rv. r>. c On pH CO 4) 4) aO e <> C V) 3 3 pH CN cl u,lN930'O*-Nn>Iin*N(S0O",N(n>Jlfl>aNa3l?O'"N(^>inv0P' tn \ oo On O' CT> ON AP00055881 Page 35 Distribution of ASL Cases by Country (Review Date -- \ A an TA.BL.E 1 USA U Qg rmfl Tlv France UK Canada Sweden Italy Yugoslavia Japan Czechoslovakia Belgium Norway 38 *** 31 ** *** 25 *** 15 13 5 **** 6* ***** 3 2 2 1 Total 145 AP00055882 * Omit 1tOl - atypical case of PVC bag extruder. ** Includes G03 aerosol can fillet. *** Includes case US 24 which was diagnosed as Choi angiosarcoma; & Frl5, 22, 23 & 24, G31 & 32, USjJ & Jb who are still alive, so far as known. **** includes one monomer worker. ***** Includes two monomer workers. i.e Western Europe North America Rest of World 85 51 9 Total 145 WPX/ASL2 - LANGIOCASES,10 Page 3 6 Pattern of ASL Cases by Factory TABLE 3 (.Review Oaxe -- V (a) W Europe Of the 85 cases in W Europe, 73 have occurred in clusters at 12 factories. Of the 31 German cases, 28 have occurred In clusters at 4 factories. ASL Cases Dynarait, Troisdorf, Germany BP, Barry, UK Hacker, Burghauaen, Germany Atochem (formerly Chloe Chimie, formerly RP) , St Fons, France Atochem (formerly PCUK) Brignoud, France Kemanord, Sundsvall, Sweden CWH, Marl, Germany 1CI, Hillhouse, UK Solvay, Tavaux, France Lonza, Waldshut, Germany Solvay, Jemeppe, Belgium Atochem, St Auban, France 12 11 9 9 8 5 A 4 4 3 2 2 73 NB: There are 32 pre 1962 PVC plants in W Europe; 19 of these have had ASL cases (Ref Table 8) (b) N America Of the 51 cases In N America, 42 have occurred at four factories out of a total of 55 factories. In N America 42 plants have not had ASL cases. ASL Cases BFG, Louisville, US BFG, Shawinigan, Canada UCC, S Charleston, US Goodyear, Niagara Falls, US 15 12 10 5 42 NB: There are 29 pre 1962 PVC plants in N America; 13 of these have had ASL cases (Ref Tables 9 & 10) (c) Rest of World The 9 ASL cases are believed to be In one cluster of 4 and two clusters of 2 cases. Wl'X/AS L2 - LANCIOCASES, J 1 AP00055883 Page 37 TABLE 4A (.Review Dace -- \ ISBS") (Years from first Exposure to Diagnosis) Country No of Cases Total Years Average W Europe Belgian 2 35 17.5 France 25 689 27.56 * Germany 31 632 20.38 * Italy 6 127 21.16 Norway 1 22 22 Sweden 5 122 24.5 N America UK 15 350 23.33 * 85 1977 23.25 W Europe Average US 38 993 26.13 * Rest of World Canada 13 314 24.15 * 5_l 1307 25.62 N America Average Czechoslovakia 2 30 15.0 Japan 3 59 19.66 Summary Yugoslavia 4 9 85 174 21.2 19.33 Rest of World Average W Europe 85 1977 23.25 AP00055884 N America 51 1307 25.62 Rest of World 9 145 174 3458 19.33 23.84 * World Average with * 10 cases, France, USA 6 Canada have ani average latency period above world average; Germany below world average. UPY/ AQf o Page 38 DISTRIBUTION OF LATENCY PERIODS TABLE 4B (Review Date - 1 Jan 1989) | Belgium 1 1 | 0-9 yrs } I 1 1 11 1 j 11 1 1 10-14 yrs | 15-19 yrs | 20-24 yrs | 25-29 yrs | 30-34 yrs 11 1 1 11 1 1 11 1 1 1 2| t 1 | Canada 1 ! | Czechoslovakia 1 | France 1 I t Germany 1 3I 1 1| 1 1| 1 5| 1 1| 1 41 91 5 3 10* | I f 1 1 | 2I t 1 1 91 l 5| 1 3 2 I Italy 1 1 2t 2 1 2 1 | Japan 1 1 1| 2| 1 | Norway 1 1 1 1| 1 | Sweden 1 UK l I t1 1 21 \ 21 1 11 J 5| 1 | 5 | 3 1 USA | Yugoslavia | TOTAL 1 l 1 1 1 11 1 2 12 * Includes G 03 aerosol can filler 1 1 1 1 1 | 1 7| I 1 1 1 33 | 1 91 1 4| 1 1 37 | 1 B1 1 1 I 1 33 | 1 5 15 11 35+ yrs | | Total i1 11 11 11 2 | Average | Latency | Period 1(Table 4A) | 17.5 2 1 1 13 I 24.IS I1 11 2| 15.0 l1 5 1 \ 25 t 27.56 1 1 31 | 20.38 11 6| 21. 16 11 31 19.66 I 1 1 | 22 11 51 24.5 11 1 1 15 | 23.33 7 1 1 38 1 26.13 11 11 4J 21.2 11 11 14 | | 145 \ 23.84 11 AP00055885 WPX/ASL2 - LANGIOCASES,13 TABLE 4C Page 39 (Review dace l January 1989) LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE MAX POSSIBLE I YEAR OF LATENCY PERIOD 1 ARITHMETIC MEAN LATENCY PERIOD J FIRST EXPOSURE (NO OF YEARS) j OF LATENCY PERIODS I1 49 | 1939 38* 1 1 48 I 1940 1 289 36.12 1 47 I 1 37,21,37,41 |8 46 1 2 32,38,45 5 45 1 3 14 1 |5 16 38,14,32,42,45*** I 28,11,24,20,24,34,39,1 44*** | 27,22,28,29,37 | 21,29,31,26,28,15,23,1 886 31 28.58 1 1 I I 1 1 30,35 ! 1 41 | 7 29,24,29,28 1 1 40 1 8 l 28,24,34 | 1 19 30,26,20,38 1 559 - 25.41 | 1950 26,22,31,19,23,14,33 | 22 1 \1 19,28,17,28,34.29 I 1 36 1 2 21**,15 1 1 35 1 3 25,22,23,22,20,31,22,1 1 1 32*** { 1 14 1 21,21,25,25,21,28***,) 22 | 849 - 22.94 1 1 15 22,23,24,14,19,21,27 I 37 ) 1 27*** 24,28,30*** 1 1 16 21,12,27***,32 | 1 31 1 7 19.17,15,13,16,28,-30 1 30 1 & 18,18,15,17,20,29*** 2 1 9 1 16,21,25,27 1 598 - 19.29 1 1960 13,18,21,25,24,25 1 31 |1 15.16.16,16,19,19,12 1 26 i 2 13.18,L7,12,18.21,26 1 25 1 3 16,17,20,21,25 1 1 4 1 16,17 1 246 17.57 I5 11,19,20 [ 14 1 6 1 9,18,21 1 21 I 7 1 16 1 20 ( 8 1 18 1 9 1 13 I 1970 1 1 1 31 15.5 12 VIOLA 16 1 2 15 1 i i 1 4! | TOTAL 1 145 CASES 11 1 1 MALTONI 1 GOODRICH 1 3458 - 23.84 1 145 * Cholangiosarcoma ** Aerosol can filler *** The following are still alive, so far as known Frl5, 22, 23 & 24, G31 and 32, CJS33 and 36 VPX/ASL2 - LANGIOCASES,14 AP00055886 T TABLE 4l> Page 40 (Review dice 1 Januarv 1989) LATENCY PERIODS OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL ~ LOCATION ' --------------------- MAX POSSIBLE LATENCY PERIOD YEAR OF FIRST EXPOSURE 49 1939 43 1940 47 1 46 2 45 3 4 5 6 41 7 40 8 9 1950 1 36 2 35 3 4 5 6 31 7 30 8 9 1960 1 26 2 25 3 4 5 6 21 7 20 8 9 VIOLA 1970 1 12 1 MALTONI 3 1 TOTAL CASES LATENCY PERIODS IN WESTERN EUROPE | NORTH AMERICA 1 38* 37,41 1 j 38,45*** I 28,44*** 27 1 ) 21,29,31,33 29 I I 28,34 30,26 1 1 26,22,31 1 19,28,34,29, l 21** 25,22,22,32*** 1 1 21,21,25,25 | 22,23,24,27***24,28 | 30*** 21,12,32 j 19,17.15.13,28 1 18,18,29***28 I 16,21,25,27, 13,18,21,25,25 f 15,16,16,16,19,19 13,18,17,18.21.26 16,17,21,25 1 t i 16 11,19 I 9,18,21 16 18 13 21,37 32,38,45 14,32,42 11,24,20,24,34,39 22,28,29,37 26,28,15,23,30,35 24,29,28 24 20,38 19 17,28 15 23,31 21,28*** 14,19,21,27 27*** 30 15 24 12 12 20 17 85 1 51 1 ROW t 1 1 1 1 1 1 1 1 1 1 ) I 23,14 1 1 1 22,20 1 22 1 1 1 1 16 1 17,20 1 1 1 1 1 1 1 20 1 I 1 1 1 t 1 19 * Cholangiosarcoma ** Aerosol can filler *** The following are atill alive, so far as known Frl5 22, 23 & 24, G31 and 32, US33 and 36 WPX/ASL2 - LANGIOCASES,15 AP00055887 TABLE 4 Page 4 i (Review date l January 1989) PLANT 1 | START I UP i DATE LOUISVILLE USA TROISDORF W GERMANY SHAWINIGAN CANADA 1 | 1940? 1 1 I 1954 1 | 1943 I (1941? BARRY UK | 1948 1 S CHARLESTON I 1939? USA 1 LATENCY PERIODS OF ASL CASES | NO OF | AVE RAGE IN SPECIFIC PLANTS (10 OR MORE CASES) | CASES | LATENCY PERIOD 11 1t 1 12,14,15,19,19,20,24,27,28,28,28,29,29 1 31,45 1 t 15 | 1 24.53 years Ii 12,13,16,16,18,19,19,21,23,25,28,29 1 12 ! 19.91 11,12,14,21,22,23,24,24,26,28,42,37 9,17,18,28,31,33,18,19,18,21,32 11 11 1 12 | 1l !1 1 11 1 11 23.66 22.18 24,30,32,32,34,35,37,38,38,39, 11 1 10 | I1 33.99 WPX/ASL2 - LANGI0CASBS,16 l AP00055888 Page 42 (Review date 1 January 1989) TABLE 4F LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPECIFIC PLANT (10 OR MORE CASES) YEAR OF FIRST | LOUISVILLE| TROISDORF | SHAWINIGAN | BARRY EXPOSURE 1 USA W GERMANY | CANADA j UK 1939 1 1 1! 1940 ) 11 1f 1 21 1 21 31 1 1 14,42 t 1 4 1 20 5 1 28,29,27 1 11,24 f 22,37 1 1 6I 7 1 29,28 | 26,28 1 24 1 1 8 1 24 11 9 1950 1 1 19 1 11 1 I 31,33 11 29 1 f 28 2 1 15 1 11 3 1 31 1 23 1 4 1 28 21,25 1 1 5 1 14,19 ! 23,28 1 1 61 71 1 12 1 13 ) 1 | 32 1 81 1 11 9 1960 1 1 1 11 11 2 1 12 16,16,19,19, 1 12 1 18 1 1 I 13 31 1 1 17 41 1 1( 51 61 1 1 1 I 19 1 | 9,18,21 71 1 11 81 1 1 1 18 91 1 11 1970 l ! 1 ! 1 11 11 21 1 11 ( S CHARLESTON J USA 1 38 1 1 37 1 32,38 1 32 ! 24,34,39 t 1 30,35 I 1 1 1 1 1 1 1 1 ) 1 1 1 1 1 1 I 1 1 1 1 l 1 1 1 WPX/ASL2 - LANGIOCASES,17 AP00055889 Page 43 TABLE 4G (Review dace 1 January 1939) | PLANT l | START-UP DATE I LATENCY PERIOD OF ASL CASES | NO OF ! AVERAGE PERIOD l )IN SPECIFIC PLANTS(4-9 CASES)! CASES 1 I1 | BURGHAUSEN I | W GERMANY | 1933 1 11 1 17,21,22,25,24,13,21,32,30 I 9 ( 22.77 years 1 11 | | ST FONS 1 | 1939 1 1! I 21,28,29,37,38,27,41,34,44 | 9 I 33.22 | FRANCE | I 11 | BRIGNOUD | FRANCE ) | 1950 1 11,16,18,26,30,25,34,45 1 1 | 8 | 25.62 |1 | SUNDSVALL I I SWEDEN | 1945 l 16,19,27,29,31 I | 5 | 24.4 1[ lNIAGARA FALLS | USA \ 1 1 SPLIT 1 | | YUGOSLAVIA! 11 1 MARL ! | W GERMANY | 1 | TAVAUX | FRANCE 1 | | 1947 1950 1948 1953 \ 15,17,21,23,38 I I 20,20,22,23 I ! 15,16,22,21 1 1 | 19,16,21,26 1 l5 1 |4 1 | 4 ! 1 |4 1 1 22.8 1 1 I 21.25 1 1 I 18.5 1 | 20.5 1 I HILLHOUSE 1 UK 1 | | 1 1940 | 28,25,28,25 [ t | 4 1 26.5 11 11 WPX/ASL2 - LANGI0CASES,18 AP00055890 AP00055891 Page 44 TABLE 4H (Review date l January 1969) LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPECIFIC PLANT (4-9 CASES) t YEAR OF iBURGHAUSENl (first exposure* I1 1939 1 1940 1 w Germany! i 1 1 11 1 2 3 4 5 6 7 6 9 1950 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 11 1 21 l 3 125,32 | 4 121 | 5 122,24,30 | 61 7 117 1 1 8 9 1960 1 f 121 1 1 | 1 2 3 4 5 6 7 8 9 1970 1 2 1 1 1 1 1 1 1 ( 1 13 1 1 1 1 1 I 1 1 I 1 1 1 1 1 1 1 ^Monomer worker 1 ST FONSi FRANCE * 1 1 1 37,41 1 1 38 1 44 1 29 1 28,34 27 21 J BRIGNOUDl FRANCE 1 1 1 45 1 1 26,30 34 1 1 18 16,25 1 1 1 1 11 1 1 1 1 1 1 SUNDSVALLl SWEDEN ( 1 1 1 1 27* 31 29 ! 1 19 1 t 1 1 16 t 1 1 1 1 NIAGARA | FALLS 1 USA | SPLIT \ marl j yugo-ih Germany! SLAVIAJ | TAVAUX FRANCE l1 ii 1 1 11 li li 1i 1 1 1 1 15,23 38 17 1 1 1 i l 12 3* 1 I I 20 1 22* 1 1 i I 1 | t 1 | 22 | 1 I l 1 1 1 1 1 1 21 1 1 11 1 1 20 1 | 1 1 1 19 1 11 1 I1 1 115,16 1 121 | 26 1! t 16,21 11 11 1 1 11 1t 1( it 11 11 t1 1 11 1 1 H1LLH0USE 1 UK 1 1 1 1 1 1 1 26 1 1 1 1 1 1 1 1 1 1 25 1 1 | 28 1 1 \ 1 | \ 25 1 1 1 1 I | 1 1 1 I i <0 (0 *-* 4J CO 0 <= 4> e t- to U 3 ln < a _ y--1 CO jO H u u Q. to c s- to 5o <i> <u H o O 0> 03 .a la <V n 3 (a JJ X 0) sc a liv e , so fa r as known: TABLE 5 * * Does n o t in c lu d e the fo llo w in g who are s t i l l a. ou 3 03 J* a to Cu O' 00 US33 & 36 o la sj <o s 69 0) a p r-H c<J AP00055892 Page 46 TABLE 6 {Revlev dace 1 January L989) ASL CASE NUMBERS BY YEAR OF DEATH AND GEOGRAPHICAL LOCATIONS (EXCLUDING Ic.01) | KEY t | EVENTS 1 1955 1 7 8 9 1960 11 2 3 4 1 Viola 1 Maltoni |Goodrich 6 7 3 9 1970 l 2 3 4 5 6 7 8 9 1980 1 2 3 4 5 6 7 8 Total WESTERN EUROPE 1 ! NORTH AMERICA 1 1 1 Cl | C2 1 1 REST OF WORLDj 1> 1 i 1 1 1 1 1 j US8 | C3 i t US5 1 1 1 1 { 1 I Cz2 11 t1 FI 1 1 | C4,C5,US4,US7,US10 1 G1 Swl G2 1 GS12.US16 1 US L1 I C6,US2 1 1 1 N1,Sw2,UK1,It2 C3** G4,G5,UK3 1 C7 I C8,US1 ,US3,US23 ! C9,US13 1 I Y1, Y 2 , Cz 1 1 F2,F3,G6,G7,G8,It3 M,F4,F5,F6,F7,Sw3 FS,F9,G10,Gli,G12,Sw4 F10,FIl,G9,G13,G15 G16,G17 1 US6,US9,US18,US26 I US19,US20,US22, 1 CIO,US21,US24* | US27.US28 1 1 Japl 1 Jap2,Y3 1 1 Y4 1 F12,F13,UK4,UK5,G18 1 1 UK.6 , UK.7 ,GL9 ,Sw5 G2Q ,G2LUS | USL7, US29, US30,US32l It4,F14,UK8,G22,G23 1 G26 t UK09,It5,F17,B2,G24,G25,G30| (JK10, F16, F18, G27.G29 1 UK11, UK12,F19,F20,G28 F21,UK13,It6,It7 l I l F25 ,UK14,UK15,UK16 79*** 1 1 US31,C12 US35, US34, US38 US37,OS39 Cll US40,US41,C13 49*** 1 1 1 1 { Jap 3 1 1 1 19 11 * Cholangiosarcona ** Aerosol can filler *** Does not include the following who are still alive, so far as known: Frl5, 22, 23 & 24, G3t & 32, US33 & 36 WPX/ASL2 - LANGI0CASES.21 AP00055893 Page 4 7 (Review dace 1 January 1989) TABLE 7 ASL CASE NUMBERS BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL LOCATION (EXCLUDING It.01) 1 KEY | | EVENTS | 1 1 | | 1 | | 1 | 1 | I I [ I 1 I I 1 1 1 1 1 1 1 l 1 1 [ 1 i 1 1 1 1 Viola 1 1 1 ! 1 1 ! 1 1 1 1 ( 1 1 l f 1 1 1 1 1 1 1 1 1 1 1 I 1 1 1 1 1 1 | t1 1 i WESTERN EUROPE I NORTH AMERICA | REST OF WORLD 1l 1 11 I 1939 1 1 US24* 1 40 ! 1 |Fr1 1 ,Frl6 1 I C3,US27 1 1 21 i US13, US29,US40 1 3 |Fri4,Fr24*** | C2,US19,C11 l 4 1UK1,Fr23*** | C1,C5,US5,US7,US28, US35 | 5 | Sw2 1 C4,US3,US9,C12 1 6 IFr1,Fr3,Sv4 | C7,C9,US8,US11,US21 ,US3I| 7 I Sw3 1 C6,US22,US26 1 8 |Fr9, Fr17 9 )Fr12,Fr4 1 US! 1 US12.US41 1 1 50 lFr7,N1,UK8,UK9 l ISwl,UK5 Fr20,G3Q l US16 1 US10, US32 IY2, Cz2 1 2 IG3** 1 US4 1 3 |G15,It3,G26,G31*** I CIO, US37 |Japl,YI 4 |G7,G8,UK4,G19 1 US18 ,t)S33*** | Y3 5 IG11 ,G16,G18, Frl5*** 1 US2,US17,US20,US34 1G23,G28,G32*** 1 1 1 6 |FR10,G1,UKI5 1 US36*** 1 7 }Fr8,G4,It2,G2,UK12 t Cl 3 iCzl 8 |Fr6,Bl,Fr22***,It7 | US23 ) Jap2 ,Y4 9 |Fr2,1t4,Frl9,Fr21 1 1 60 |G5,G13,G25,G28,It6 1 US39 1 l |G9,GI0,G12,G17,G2Q,G22 I C8 1 2 |G6,UK6,G21,B2,G29,Fr25 1 US6 t 3 1Frl3, UK7,Frl8,UKl6 1 US38 1 4 I Sw5 \ US30 1 5 |Fr5,UKU 1 | Jap3 6 |UK3, UK10,UK14 1 1 7 | It5 1 1 8 IUK13 1 [ 9 IG24 1 1 70 1 l 1 1111 112 1 | Maltoni | 31 | 1 1 | 1 1 11 1 1 Total (85 1 11 1 1 51 1 1 |9 ! * Cholangiosarcoma (US24) ** Aerosol can filler (G3) *** Frl5, 22, 23 & 24, G31 & 32, US33 & 36 are still alive, so far as known WPX/ASL2 - LANGIOCASES,22 AP00055894 Page 48 WPX/ASL2 - IAN3IOCASES.23 (Review date 1 Jaruary 1989) TABLE 8 WESTERN EUROPE PVC PRODUCERS - STaKT^jTMISS vs ASL CASES (CMITTDC QD3 & Ic.01) | StART-UP) COUNHOr W | (TMPANY NMC I LOCATION 1 ASL CASE MMBER YEAR OF YEAR. 1 t 1931 (West Germany | BASF 1 | Ludwigshafen ( 1 | 1st Exposure 1 L933 |West Germany (Wacker I &irghausen (04,07,11,15,23,24(57 >54,55,53,55.69.60,53( 11 1 (25,31,32 155 1938 1 Italy IMcntecatini | Acna 1 1 1939 | France I Rhcre-Poulenc/ (St Fans 103,09,10.11.14 (46,48,56,41,43, 1 (Chloe/Atochem 1 (15.16.17.23 (55,41,48,44 1940 (United Kingdom|ICt/EVC llhited Kingdom) ICI/EVC (Runcorn (Closed 1948) iHillhciuse (01,04,12.L6 I (44,54,57,63 1945 (Sweden IKemarerd/lbbel (Sundsvall(Stockvlk)|01,02,03,04,05 |?1,45,47,46,64 " 1946" (France 1 Rhone-ftxilenc (Roussillon 101 |46 1948 lUhited KingdantBP Chan/ICI/EVC| Barry (03,05,06,07,06,09166,51.62,63,50,50 11 1 (10.11.13.14.15 (66,65,68,66,56 (West Germany (CWH/Huls (ferl 109,10,26,29 161,61,53,62 1949 l Belgium |Solvay IJemeppe (01,02 (58,62 1950 (France (FCUK/Atochau (Brignoud {02,04,05,06,12,19159,49,65,58,49,59, 1 (France 1( IFhone-Poulen:/ (St Auban (20,24 (07,22 151,43 (50,58 1 (Chloe/Acochan 1 11 (Holland (Shell (Ramis, Rotterdan 1 1 | Norway (Norsk (Heroya, Porsgrunn 101 150 1951 I Switzerland 1952 |Italy (Lonza/ ICI/EVC (Sins (Montedison/ (Temi 1 107 1 (56 1 1 Italy (Moplefan 1 (Montedison/EVC (Ftorto Markers f 102,06 1 (57,66 1953 (Austria IHalvlc/Solvay JHallein 1 1 (France I Solvay (Tavaux (06,13.18,25 157,63,63,62 (Italy ISolvay |Ferrara |03 153 1 Spain (Rio Rodano IHemanl 1 1 |United Kingdanl BXL/&IP/N0RSK (Aycliffe (Vfest Germany Ifcechst IGendorf l 118 1 (55 1954 (West Germany (Dynanit ITroisdorf 101,02,08,12,16,17(56,57,54,61,55,61, 1955 1956 1 (Spain (Spain 11 |Msanco Iberiaffixizon (Caiqsa JSabinanigo (19,20,21,22.27,30(54.61.62.61.55.51 f( 11 1 (Hispayic/SolvaytTorrelavega 1 1 1958 (West Germany (Solvay (Rheinberg 1 1 1960 (Italy |S C Ravema/EVCI Ravenna 104 159 (West Germany (Uxiza/ICI/EVC IWaldshut 1961 (Italy (Montedison/EVC (Brindisi (06,13,28 1 (62,60,60 1 1962 | Portugal [Cires (Oporto 1 1 1965 (France (Rhone-Foulenc (Montlucon (21 159 (Italy (Italy (West Germany Iftjzzi IFeneac (Wacker (Ferrandina (Mira, Venice (Cologne 1 105 1 ! (67 I 1966 (West Germany 1967 |France |Spain (Greece "W (Belgium (Hoechst (Atochan (Rio Rodano (Esso Pappas (Badlphll (Knapsack(Frankfurt)|05* (Balan 1 (Miranda de Ebro 1 IDiavata Salonika 1 1Antwerp 1 (60 1 1 I 1 1969 1 United Kingdaml Vinatex/Norsk 1Staveley (Italy (Rumanica/EVC (Cagliari Sardina t 1 1 1 Cbntinued AP00055895 Page /*9 Table 8 - Continued VESTEEN EUROPE PVC PRtXiUCERS - START UP DATES vs ASL CASES (OinTIxC 033 & tt.OD j START-UP! CCUNUff NAME ( CCKPANY NAME 1 IDCA1TCN j YEAR 1 -- 1970 Utalv !1 IS"'|Porto Torres Sar KlnprinttitICI/EVC IBuncom ___ 1971 [Spain__________jHispavic/ SoivayIMartoreli | ASl CASE TIMBER \ \ \\ 11 11 | 1972 1976 1977 - 1962 1 United Kingdom!BP Chem IBaglan Bay itwiW 1 France 1 |D$l iBeek Umtwrg |Soc Art D'viryUMazingarbe i(CEF) 1 jUfest Germany (ICI/EVC ,j IVoslapp fWLlhelmshaven 1 ! 1 ) 1 1 1 ( \ 1 1 | 1 1 YEAR CF 1st Exposure \ * laboratory wetter in Research Department WPX/ASU - LAM3lOCA$S>2<4 AP00055896 Page 50 TABLE 9 (Review dace 1 January 1989) USA PVC PRODUCERS - START-UP DATES vs ASL CASES |START-UP | COMPANY NAME LOCATION | ASL CASE | YEAR OF | t YEAR 1 1 19 39? |*UCC 1 | Dow S Charleston Midland (made 1 NUMBER | 1st EXPOSURE 1 107,13,19,21,24,144,42,43,46,39,"! 127,28,29,31,35 141,44,42,46.44 i || | 1 | 1940? | *SFG Saran copolymer) Louisville 1| | 101,02,03,04,05,148,55,45,52,44, | 1 1 1 1946 [*UCC/Dow 106,09,16,17,22,162,45,50,55,47, | 126,33,34,37,40 147,54.55,53,42 I Texas City (Partially closed 1977)| | 1 1947 I Goodyear I 1948 I Firestone/ Niagara Falls Pottstovm 108,10,11,20,41 146,51,46,55,49 l |12 |49 j 1 Occidental | Uniroyal Painesville 1 | 1 I 1 j 1 | 1950 j Monsanto 1 | 1952 | Dow I BFG (closed 1975) ! Springfield 132 (Closed 1975 1 Midland (No PVC since c 1975) Avon Lake (18 I 151 1 l |54 i | I | i 1 1953 1 Diamond/BFG Deer Park 1 1 1 1954 1 General Tire/ ** Ashtabula 136 156 \ DiversiTech (Closed 1984. Reopened 1986 by Vygen) j | | | 1956 | Air Products I Atlantic Refining Pensacola (Pace) I Brooklyn(Closed late 1960s) 1 I f | 1 Borden I Conoco Leominster (Closed 1984) Hebronville (Closed 1975) 1 t | { 1 BFG Niagara | 1 | | Great American I Plastics Fitchburg (Closed 1983) 123 | 158 1 | | | Hooker Hicksville (Closed 1980-81) 1 1 I Pantasote Passaic(Closed 1984) 39 160 | | 1957 1 Atlantic Tubing ] Tenneco/ Cranston (Closed 1967) Flemington NJ 130 1 159 I | 1 Occidental (Closed 1985) 1 1 ( | 1958 | Keysor Century l Air Products Saugus, Cal t Calvert City(Paducah) 38 t |63 { ( 1 l 1960 | BFG l I Borden (Closed March 1982 Re-opened October 1983) Long Beach, Cal (No PVC now, ! Formerly shown as Watson) 1 Illiopolis | | 1 { | J ! 1962 | Tenneco/Occidental Burlington NJ I I UTl 1 Conoco/Vista Aberdeen, Miss I | Stauffer Long Beach, Cal (Closed 1982) 1 1 t 1 1 1 1 1965 1 Conoco/Olin 1 Ethvl 1 1966 | Diamond/Georgia Assonet, Mass (Closed by Olin 1975) Baton Rouge (Closed 1984) 1 Delaware City I 1 I 1 1 f Gulf |Gen Tire/Pantasote 11 Mt Pleasant WVa [(Closed 1982^ i ( ! 1 BFG 1 Stauffer/Formosa Henry, 111 J 1 Delaware City (Sold to Formosa 1981) 1 1 1 1967 1 Allied/Roblntech/ 1 Georgia Pacific I Hooker/Occidental Painesville, 0, (No PVC made by Roblntech, GP converted to polystyrene) J Burlington NJ | 1 1 1 1 | 1968 IFirestone/Occidental Perryville (Closed 1982) 1 1 WPX/ASL2 - LANGIOCASES,25 Continued AP00055897 Page 51 TABLE 9 (Continued) USA PVC PRODUCERS - START-UP DATES vs A5L CASES START-UP| YEAR t 1969 i 1 1971 | 1972 | 1973 | 1974 | 1 I 1975 1 1 1 1 1979 1983 1986 { 1 j | COMPANY NAME | 1 BFG 1 Goodyear/BFG I Conoco/Vista ! Nat Starch I Borden | Atlantic Tubing/ } Tallyrand I Shintech 1 Certain-teed } Georgia Pacific/ | Georgia Gulf 1 Tenneco/Occidental! Firestone/ 1 Occidental [ Formosa | Vygen ** \ LOCATION 1 ASL CASE I NUMBER Pedricktown NJ ) Plaquemlne 1 Oklahoma City I Meredosia, 111 \ Springfield 1 Cranston Rl (Closed 1982) 1 Freeport, Tex 1 Lake Charles I Plaquemine, La | 1 Pasadena, Tex [ Addis (formerly shown as Plaquemlne) 1 Point Comfort, Texj Ashtabula, Ohio ! 1 YEAR OF ) 1 1st EXPOSURE 1 1 ! 1 ! 1 1 1 1 1 1 1 1 1 1 1 1 * My databank has no information on UCC before 1946 or BFG before 1950 ** Refer to same plant at Ashtabula, bought by Vygen from DtversiTech. NB Some of the plants In this list were closed down, some have changed ownership over the years, some have changed their product. WPX/ASL2 - LANGIOCASES,26 i I I I AP00055898 Page 52 TABLE 10 (Review dace 1 January 1989) CANADIAN PVC PRODUCERS - START-UP DATES vs ASL CASES )START-UP | 1 YEAR l 1 | 1943 1 1(1941?) | | 1 1 1 1 1951 ) 1 1 1 1957 | 1 1 1 1966 | 1 | 1 1979 | 1 COMPANY NAME l LOCATION 1 1 Goodrich | Shawinigan (Formerly Gulf) | (Formerly Shawinigan Chemicals) 1 ASL CASE l YEAR OF 1 NUMBER 1 1st EXPOSURE 1 101,02,03,04,05 144,43,41,45,44, 106,07,08,09,10, (47,46,61,46,53 ! 11,12 143,45 (formerly Canadian Resins & Chemicals) 1 1 1 Monsanto 11 | La Salle (Closed 1975) 11 Goodrich 11 | Welland (Niagara) 1 13 157 Esso (Imperial Oil) 1 1 | Sarnia l t 1 11 1l Diamond Shamrock Alb/I Fort Saskatchewan 1 BF Goodrich I 1 WPX/ASL2 - LANGIOCASES,27 AP00055899 Page 5 3 (Review date L January 1989) TABLE 11 EASTERN BLOC PVC FACTORIES - START-lfP PATES vs ASL CASES START-UP I COUNTRY NAME | COMPANY NAME YEAR I iqiqTEast Germany (State Company 1941 I Russia 1950 [Yugoslavia [State Comps I JugoVinil 1951 iCzechoslovakia!State Comps 1955 1956 19 57 "[East Germany [Rumania I Poland Rumania [State Comps [State Comps State Comps .State Cotaps 19 58 1959 1961 1963 1965 1967 1969 19 70 L 9 72 1975 1976 1977 1 Rumania [Hungary |Rumania [State Comps iState Cotaps State Comps [Yugoslavia [Phis [Bulgaria |Poland [Russia State Comps State Comps State Comps I Rumania |Russia State Comps iState Comps |Yugoslavia [Vinllplastlka |Czechoslovakia!State Comps [Russia [State Comps [Yugoslavia [Hip lRumania State Comps LOCATION Schopau I Vladimir et af [Split ' Novaky Bitterfeldt ; Iceohim joswelcim" (Dwory) Itimaveni iTurda [Ristiov I Betente Borsod iBorgesci Skopj i I Varna [Tarnow [IHetilosk IRimnicu Vllcea lVolgograd [Zadar INeratoylce [Kalush Area :Pancevo IRimnicu Vilcea ASL CASE NUMBER QU02,03,Q4 01,02 _____ YEAR OF 1st Exposure 53,50,54,58 57,50 WPX/ASL2 - LANGIOCASES,28 AP00055900 Page 54 (Review date 1 January 1989) TABLE 12 JAPANESE PVC PRODUCERS - START-UP DATES vs ASL CASES START-UP | COMPANY NAME YEAR 1950 1 Chisso Corp | Kanegafuchl Kag | Tekkosha 1951 I Mitsui Toatsu 1952 | Mitsubishi Mon ( Sumitomo Kag 1951 1 Denki Kagaku | Nippon Zeon I Toa Gosei 1955 l Ryo-Nlchi 1956 | Nippon Zeon 1 Nisshin Kagaku 1957 I Kureha Kasei | Shinetsu Kag 1960 | Denkl Kagaku | Kanegafuchl Kag 1964 I Chisso Corp 1966 | Tokuyama Seksui 196? } San Arrow Kagak 1 Sumitomo Kag 1968 | Ryo-Nichi | Shinetsu Kag 1970 1 Chisso Corp I Denkl Kagaku | Kanegafuchl Kag 1 Kawasaki Yuki 1 Mitsui Toatsu I Nissan Kagaku 1 Shinetsu Kag 1971 | Tekkosha 1973 1 Asahl Glass 1974 | Toyo Soda 1975 1977 | Central Kagaku S Toyo Soda | Unknown 1 LOCATION 1 1 Minamata 1 Osaka I Sakata i Nagoya I Yokkalchi 1 Kikumoto 1 Shibukawa | Kambara I Tckushima l Uozu I Takoaka 1 Takeo 1 Nishiki 1 Naoetsu ! Ohmi 1 Takasago 1 Chiba I Tokuyama 1 Tokuyama 1 Chiba I Mizushlma ! Tokuyama i Mizushlma 1 Goi (Chiba) 1 Kashina 1 Kawasaki 1 Sakai I Chiba ! Kashima f Yokkaichi 1 Hayatsuki ) Sakata I Yokkaishi I Kawasaki 1 Yokkaichi 1 Kashima | ASL CASE I NUMBER 1 | 02 1 1 01, 03 1 1 1 1 1 1 I 1 1 1 1 1 1 f 1 1 t 1 1 1 1 1 1 1 t 1 I 1 1 1 1 1 year of I 1st EXPOSURE 1 1 58 1 1 53, 65 1 1 1 1 1 1 1 ! ! 1 1 1 1 1 1 1 1 1 I 1 / 1 1 1 1 1 1 1 1 1 1 1 WPX/ASL2 - LANGIOCASES,29 AP00055901 Page 55 (Review date 1 January 1989) TABLE 13 SOUTH AND CENTRAL AMERICAN PVC PRODUCERS START-UP| COMPANY NAME YEAR 1 1953 | Monsanto Mexica ' 1954 1955 1956 1960 1 Policyd I Geon Do Brazil 1 Elchlor/Solvay 1 Electrochlor t Viplastic 1961 I Indupa 1965 | PET Columbiana 1966 1967 I Carburo De Col | Plasticos Omega | SOC Paramonga 1968 1970 19^1 19^5 \ Primex [ Policasa | Petro Dow I Polimeros Mex I Rico Chemicals 1976 | Petroplas 1$77 I Indust Resistoc 1978 1 Kuls Braail [ Polychem | Policyd 1979 1 PET Camacari 1 LOCATION [ ! 1 Lecheria (Mexico) 1 1 | Mexico City (Mexico) I Sao Paulo (Brazil) | Sao Caetano (Brazil) ! 1 1 ICapitan BermudezCArgentina)) | Mendoz (Argentina) 1 | Cinco Saltos (Argentina) 1 I Cartagena (Colombia) 1 t Medellin (Colombia) 1 | Mexico 1 | Paramonga (Peru) I | Puebla (Mexico) 1 [ Managua (Nicaragua) [ Conception (Chile) l 1 1 St Martin Puebla (Mexico) 1 I Guyanilia (Puerto Rico) 1 f EL Tablazo (Venezuela) 1 | Tlazcala (Mexico) 1 \ Cubato (Brazil) 1 I El Salvador 1 I Coatzacoalcos (Mexico) 1 1 Camacari Bahia (Brazil) 1 ASL CASE NUMBER 1 YEAR OF 1 1st EXPOSURE I 1 1 1 1 1 1 1 \ 1 1 1 1 1 1 1 1 1 1 1 WPX/ASL2 - LANGIOCASES,30 AP00055902 Page 56 (Review date 1 January 1989) TABLE \U AUSTRALASIAN PVC PRODUCERS START-UP DATES 1 START-UP } YEAR COMPANY NAME I Mid 1950s ICI Australia I 1960s B F Goodrich ILate 1970s ICI Australia | LOCATION 1 1 1 | Botany, Sydney 1 | Melbourne | Laverton | Melbourne I 1 1 ! t ASL CASE NUMBER 1 YEAR OF t 1st EXPOSURE 1 I 1 1 1 WPX/ASL2 - LANGIOCASES,31 AP00055903 Page 57 (Review date 1 January 1989) TABLE 15 MIDDLE EASTERN PVC PRODUCERS START-UP DATES |START-UP 1 DATE |Sept 1986 COUNTRY NAME Saudi Arabia 1 COMPANY NAME 1 11 LOCATION \1 | National Plastic jAtabian Petrochemical Company i Company iMadiant } (Ibn Hayan) 1Al-Jubail 1 |AL-Sinahyah 1t 11 11 WPX/ASL2 - LANGIQCASES,32 AP00055904 VZ*I m So *vs ;uwut25---zai s Z 1a ao vu1;Xc11ssaCwka!sl .B^;J i n1 y8SsE3ej IMA u LU 5 (3 1 3u 5 S - si S3 o VCQft, t3J s 3S23 | |V) * UU* Nta) O*0) 1Q" <A - SS 333 (A - II SH3= 2333 > Ek -< fOa* f " s<o *i .o3 N 33X 5- - X<>o.2w SE3? 3M<Mfc = 11 - AP00055905 1 1> Tuesday, February 10, 1976 } Move to Halt Scllnig Of Spray Adhesives Prompted Abortions I ** r Birth-Defect:; Scare Jic.siilted From U.S. Action; Fears Later Found Without Basis ^ By JCRAY E. Bishop I Stntf Reporter of Tho Wall, STr.r.BT JOURNAL | : MEW YORK - Federal action lc* stop! marketing of a consumer product due to; 'suspicions that it might he licked to birth] ; defects, and the resulting publicity, appar-S ently frightened some pregnane -women into! obtaining abortions--even though it turned- cut that the suspicions were unfounded and the government move was quickly re scinded. The incident Involved action by the U.S. Consumer Product Safety Commission eon ceroing spray adhesives used by hobbyists | and others. In August 1973, shortly after the | commission was created, it announced thatl \ tt was considering banning spray adhesives. : An Oklahoma pediatrician had found a higher incidence of damaged chromosomes In 10 persons who had used the spray adhe] eives than in 12 persons who hadrv't. He also had seen two deformed children bom to par ents who had been exposed to the sprays during or shortly before the pregnancies. Concern over the spray adhesives' possible link with birth defects led two major makers of the adhesives--Minnesota Mining < Manufacturing Co, and Borden Co.--to(. voluntarily stop marketing and distributing the products. The commission said that it ' wanted other makers to follow suit and that It was -considering regulatory action. It wanted to halt marketing as a precaution until further studies could confirm or allay , tho suspicions. It turned out that the suspicions couldn't' be confirmed by further studies and the commission's ban on the adhesives was lifted six months later. During that time, however, the commission's action received wide publicity. | A survey of public reaction, as gauged by 182 genetic-counseling centers, is published in tills week's issue of Science magazine, published by the American Association for " the Advancement of Science. The survey was limited to the genetic counselors and didn't include the experience of family phys- ' icians. pediatricians, obstetricians or other medical personnel. 1 The survey found that the centers were j aware of at least eight pregnant women who 1 I had been exposed to the spray adhesives and elected to have abortions without under going tests that would have disclosed whether tho fetuses were affected. The cen ters also reported U additional Instances where pregnant women underwent tests to determine if Ibe fetuses' chromosomes were damaged. One of the U women hid an abor tion although the genetic counselor told Imc that he was unable to confirm whether the fetus was damaged. The aborted fetus failed to show any obvious defect* although it wasn't checked for chromosome damage. The is? centers reported that they re-, ceivcd 1,100 inquiries about the adhesives' suspected dangers and estimated that It cost the centers 1,200 days of work. Inquiries were highest where local news media gave the story considerable prominence. The surveyors said that concern about possible genetic dangers of widely used sub stances "is a real one, and the report of sus picion of an effect should be taken seri ously." They added, however, that the epi[sodc with the spray adhesives "illustrates the need to distinguish suspicion of toxicity '.from evider.ee of toxicity.'' The survey was reported by Ernest B. [Hook and Kristine M. Healy of the New York State Department of Health and Al: bany <N.Y.) Medical College. AP00055906