Document M4MBN05v0oYnNKKZkvr40p359

FILE NAME: Oil Industry and American Petroleum Institute (API) DATE: 1947 Jan 30 DOC#: API021 DOCUMENT DESCRIPTION: Statement of Expenditures by the American Petroleum Industry for Fourth Quarter of 1946 (RING LABORATORY OF APPLIED PHYSIOLOGY ^ COLLEGE OF NEDICINE-EDEN AVENUE January 30 1947 CABLE ADDRESS' KETLAB. CINCINNA TELEPHONE- UNIVERSITY 2665 Mr. D. Stroop, The American Petroleum Institute, 50 West 50th Street, N e w York City 20. Dear Mr. Stroop: I am sending you herewith in Dr. Kehoe's absence from the Laboratory, a statement of expenditures made on behalf of The American Petroleum Institute for the fourth quarter of 1946. Dr. Kehoe asked that this be forwarded without comment. However, if there is any question concerning it, please do not hesitate to direct it to Dr. Kehoe. Very truly yours E. Hi Fortlage/ Secretary to D r . Khoe ' ef Enc API 04695 0 UNIVERSITY CP CINCINNATI KETTERING LABORATORY OF APPLIED PHYSIOLOGY ACCOUNT OF HB AMERICAN PETROLEUM INSTITUTE FOR THE FOURTH QUARTER 19^6 eiLARTSS (Based on P r o p o r t i o n of Time A c t u a l l y 5^ Spent on project) Erancis Heyroth Karl Kitzmiller Wm. Deichmann Harold Schlecht Sylvan Wltherup - Chemical and Toxicological Assistance - Pathological Assistance - Toxicological Assistance - Technical Assistance - Technical Assistance 3-70 2 2 .23 I 5I .62 47.11 03-46 308.12 fiTurKLLANEOUS EXPENSE P u r c h a s e of A n i m a l s ....................................... Proportion of Secretarial, Library, Janitors, Wash Boys, Draftsman, Shipping Clerks, Animal Caretakers e t c .......................... Proportion of Heat, Gas, Electricity, Steam, Telephone, M a i n t e n a n c e , P e n s i o n s , A n n u i t i e s e t c ............ TOTAL EXPENDITURES 44.00 210.26 305-^1 867.79 RECEIPTS ............................. EXPENDITURES - 2nd quarter 3rd quarter 4th quarter 238.58 710.55 867-79 $6000.00 1316.92 Balance Remaining for Work in 1947 $4183.08 API 04696 ' S o Copy fron D. V. Stroop for Information of liembers and Associates of Subcommittee on Carcinogenicity. 2-4-47. UNIVERSITY OF CINCI.'CIATI Cincinnati 19, Ohio Kettering Laboratory of Applied Physiology College of Ledicine Eden Avenue January 30, 1947 lr. D. V. Stroop American Petroleum Institute 50 VJest 50th Street New York 20, N. Y. Dear Mr. Stroop: I am sending you herewith in Dr. K e h o e 's absence from the Laboratory, a statement of expenditures made on behalf of the American Petroleum Institute for the fourth quarter of 1946. Dr. Kehoe asked that this be forwarded without comment. However, if there is any question concerning it, please do not hesitate to direct it to Dr. Kehoe. Very truly yours, ef Enc. /s/ E. R. Fortlage E. R. Fortlage, Secretary to Dr. Kehoe API 04697 1 <vrw UNIVERSITY OF CINCEINATI ' T A *3TTDA A C ^ T T - n TUVOT/*VT SALARIES (Based on Proportion of Tine actually ' Spent on Project) Francis Heyroth - Chemical and Tozicological Assistance Karl Kitzmiller - pathological Assistance ",,Tm. Deichmann - Toxicological Assistance Harold Schlecht - Technical Assistance Sylvan witherup - Technical Assistance $ 3 70 22.23 151.62 47.11 63.46 $308.12 ;Z3CZLLAN5CUS EXPENSE Purchase of Animals Proportion of Secretarial, Library, Janitors, Wash Boys, Draftsman, Shipping Clerks, Animal Caretakers, etc. . . . . . . . . . Proportion of Heat, Gas, Electricity, Steam, Telephone, Maintenance, Pensions, Annuities, etc.. . . . . . . . . . . . . . . . . . . . . . . . . $ 44.00 210.26 305*41 ' TOTAL EXPENDITURES .................. $867.79 RECEIPTS ................................... EXPENDITURES - 2nd quarter 3rd quarter 4th auarter 238.58 710.55 867.79 $6000.00 1816.92 Balance Remaining for Yfork in 1947 . . $4183.08 API 04698 SUBCOMMITTEE ON CARCINOGENICITY / Progress Beport April 28. 19V7. Dr. M.N. Nevqulst Chairman Medical Advisory Committee American Petroleum Institute The Subcommittee on Carcinogenicity submits the folloving progress re port: 1 - The experimental vork on animals, which vas begun last year at the Kettering Laboratory, is being continued. It is still too early to draw any definite conclusions but one of the eight samples furnished by us produced papillomata In four mice out of twenty after twentysix weeks. Whether any of the remaining samples will give positive findings by the end of this year remains to be seen. 2 - A meeting of the Subcommittee vas held In New York City on March lUth to review what has been accomplished and formulate plans for the future. It was agreed that an excellent start has been made but that much re mains to be done if the industry is to protect its employees and the general public from any carcinogenic substances which may be present In certain petroleum derivatives. 3 - On March 26th, at the request of the Subcommittee, Mr. Stroop sent out the folloving questionnaire to all members of the Advisory Committee: "Please report below the number of cases' of cutaneous or superficial cancer occurring among your employees In the United States during 19^6 In which the cancer vas al leged to have been due to the occupation. If any such cases, kindly give pertinent details such as age, sex, nature of occupation, exposure, nature and location of lesion, diagnosis, tissue report, course of disease, autopsy report If any, and whether or not a Workmen's Compensation Award vas granted." Up to date he has received reports from eight companies covering 99,^35 em ployees, none of whom developed cancer during 19^6. Beccmmendatlons: (a) The animal experiments now under way at the Kettering Laboratory should be continued, at least until the end of the current year. API 04699 Page 2 Becommendations (Cont*d); (b) Extend the scope of investigation to a good many more samples so they can be treated on a statistical basis, rather than on a com parative basis, using a small number of samples In an endeavor to get the same type of charge stock. It vould seem that the best attack vould be to get out a form letter to a number of oil com panies, Inquiring vhether they vould be villing to participate In such a program and, if so, request them to set aside barrel samples of catalytic recycle stock, catalytic reside, thermal recycle and thermal w e l d s and advise by vhat type of operation and under vhat conditions they have been produced. Then, after an analysis of responses to that questionnaire, the most perti nent samples vould be selected for further study. (c) Means must be found to refute the false and misleading state ments that are continually appearing In nevspapers and magazines as to the prevalence of cancer among those vho vork In refineries and filling stations. Respectfully submitted Dr. Mclver Woody, Chairman April 28, 19^7 Members : Dr. M.N. Nevqulst Dr. R.C. Page Dr. Mclver Woody Mr. L. C. Beard, Jr. Dr. A.E. Hoag Mr. Boy Bonelb Dr. J.P. Holt Mr. H.R. Warrick Dr. T.J. a l l y Mr. H.P. Lankelma Dr. W.I. Levis Mr. D.Y. Stroop Mr. H.H. Zuldema API 0470 For information Only - Not For Public M i o n API MEDICAL ADVISORY COMMITTEE Minutes of Meeting of Subcommittee on Carcinogenicity August 26, 19^7 A meeting of the Subcommittee on Carcinogenicity vas held at 26 Broadway, New York City, on Tuesday, August 26th, 19U7. Those present were: Dr. A. 1. Hoag Dr. J. P. Holt Dr. M. N. Nevquist Dr. fclver Woody Dr. L. C. Beard, Jr. Mr. B. S. Bonslb Mr. H. G. M. Fischer Mr. H. R. Warrick Socony-Vacuum Oil Company, Inc. Standard Oil Company (New Jersey) The Texas Company Standard Oil Company of New Jersey Socony-Vacuum Oil Company, Inc. Standard Oil Company (New Jersey) Standard Oil Develpment Company The Texas Company The purpose of the meeting was to review a progress report from the Kettering Laboratory and formulate plans for the remainder of the current year. Dr. Heyroth's letter of the 23rd was presented covering 72 mice that have died and were also examined histologically. Aside from one spontaneous mammary gland carcinoma which occurred in the control group, no tumors were found except in those mice.which were painted with sample number W-3632. Of the original 20 mice in this group, 17 died and were examined. One animal (38 applications) showed pronounced acanthosis. Another animal (32 applications) showed hyperkeratosis with slight acanthosis. In four of the animals (29 , 22, 28, 16 applications) skin sections were not remarkable. In one other animal, there was no gross evidence.of any skin tumor and no skin sections were made. Up to the present (29 weeks), no tumors have appeared in animals painted with methyl cholanthrene. Dr. Heyroth has promised to submit a more detailed report at the conclusion of the experiments. Actions taken: 1 - The fact that the mice tested with methyl cholanthrene have not shown cancer after 29 weeks, raises three questions: (a) Is the methyl cholanthrene applied in sufficient concentration (.3* in benzene)? (b) Is benzene the proper vehicle for our tests with methyl cholanthrene7 It hae been suggested that benzene may be a co-carcinogen and in view of its high volatility may evaporate so rapidly as to allow the methyl cholanthrene to remain on the skin in a dry, powdered or crystalline form which is easily lost. Why not use mineral oil as a vehicle, using a high boiling, highly refined, non-toxic white oil (such as Nujol) preferably applying the methyl cholanthrene in various concentrations? This would tie in with the physical and chemical analyses being conducted on oils that have shown toxic properties. A series of comparative tests should be instituted, employing both benzenes and the non-toxic white oil as vehicles containing various, but identical, concentrations of the methyl cholanthrene. &pl 04701  -S- i For Infornation Only - Not For Publication (c) Where was the methyl cholanthrone obtained and is it the "real stuff"? 2 - Mr. Fischer reported on the results of the special investigation of carcinogenic oils "being carried on by the Standard Oil Development Company, which indicate: (a ) Insofar as is known, the hydrocarbon type carcinogen consists of a condensed ring structure having at least ^ rings. This means that their boiling range is relatively high and very likely not lower than 700 F. Therefore, any carcinogen present in heavy, catalytic cycle oil can be assumed to have at least a structure consisting of at least It- rings. 0>) Such being the case, domestic fuel oils are safe as far as carcinogenicity is concerned. (c) However, heavy industrial fuels, heavy industrial distillate if fuels, asphalts and like materials are potentially dangerous if they contain catalytically cracked fractions of the type described under (a) above. () The danger threshold lies at or above 700 F. ASTM; anything boiling below that point should be safe. 3 - It was the consensus of those present that it would be advantageous for the companies who have conducted or who have plans for research work on this problem to submit their findings to the Subcommittee. k - It was the opinion of the Subcommittee that research work on this problem should be expanded and greatly accelerated. 5 - It was the opinion of those present that a full-time, properly qualified research worker should be assigned to this project. 6 - (a) It is desirable to assemble data regarding (1) nature, (2) frequency and (3) duration of exposure of employees and customers to intermediate or commercial products containing as a constituent heavy, catalytic distillates or residua which contain fractions boiling above 700 F. Also, to obtain the number of (1) employees and (2) customers so exposed. In order to obtain uniformity, Dr. Woody will outline the procedure for survey and approach the companies to conduct the above survey. (b) Employees who may be exposed to the substances mentioned above should be examined at least annually by the plant physician, observing the entire skin of the body particularly fear evidence of warts, papillomata and other skin conditions. (c) It seems desirable that the type and number of employees exposed to the above substances be restricted as much as possible and that suitable precautionary measures be taken to eliminate exposure. API 04702 I -3- l For Information Only - Not For Publication (d) Dr. Woody will seek the advice of Mr. Stroop as to the companies that are to be Invited to participate in this survey. 7 - Inasmuch as the Medical Advisory Committee has approved a Cancer Registry in principle, Dr. Woody will write to the members of the Medical Advisory Committee, asking them to obtain approval from their respective managements to submit the indicated data (in code if desired) concerning all cases of cancer occurring among their employees. 8 - The technical advisers of the Committee will be asked to meet and formulate their ideas as to the analysis of any samples, especially those found to be carcinogenic. 9 - At the first opportunity, Dr. Zehoe will be asked whether he can take on additional work and whether the contract with the Kettering Laboratory could be revised so that the Committee could if employ a research worker and place him in the Kettering Laboratory on loan, with the understanding that he would devote his entire time to work outlined by the Committee. Then a conference would be called to outline the work to be done. Mr. Stroop will be asked whether funds will bo available to employ the man as soon as he has been selected. Dr. Holt pointed out that at almost any university where industrial hygiene is taught, it should be possible to find one or two graduate students who would gladly devote their entire time to a research project such as we have in mind. McIW:EH Mclver Woody, M.D. CHAIRMAN 9-5-V7 API 04703 Minutes of Meeting of Subcommittee on Carcinogenicity September 9. 19h? A special meeting of the Subcommittee on Carcinogenic it/ wa- held at 25 Broadway, Rev; York City on Tuesday, September 9th, 19^7* Biose present were : Dr. T.M. Prank -- Pan American Refining Corporation Dr. A.P. Hoag - Socony-Vacuum Oil Company Dr * J .?. Holt - Standard Cil Company { T . J . ) 4< Dr. T.J. Kelly - Shell Oil Cornany Dr. M.R. Sewquist - The Texas Company Dr. Mclver Woody - Standard Oil Company of Dei; Jersey Dr. I.C. Beard, Jr. - Socony-Vacuum Oil Company Mr. P-.S. Bonsib - Standard Oil Company "(D.J.) Mr. E.G.M. Pischer - Standard Oil Development Cornany Mr. D.V. Stroop - American Petroleum Institute Dr. Robert Clinton Page, Mr. E.P. Lankelma and Mr. H.R. Warrick had written that they w i l d not be able to attend. follows: The ninutes of the previous meeting were reviewed and amended as Paragraph 1 (b), third'line, "a co-carcinogen and" should be "a co-carinogen or". Paragraph 2, (a), sixth line, "to nave at least a structure* should read "to have a structure". In discussing heading Bo. 1, Mr. Pischer stated M b reasons for re commending animal tests to determine the effect of different concentrations of methyl-cholanthrene dissolved in benzol as against the effect of the same con centrations .dissolved in wnite oil. He was inclined to think that at least five concentrations should be tested so chat two curves could be drawn, one shewing the effect of the concentrations in benzol and the other che effect of the same concentrations in white oil. Readings Do. 3 5 and 6 were discussed together and general agree ment was reached that the following questions should be investigated: 1 - Effect of actinic r?ys on skin contaminated with the possible carcinogen. 2 - Iffect of washing with soap and water, or some other solvent, after application of carcinogen. API 04704 I 3 - The value of protective creams. ** - Effect of varying the site of application by painting a given animal at a different spot.each time. 5 - Effect of applying carcinogen for a certain number of times (12 weeks?), then discontinuing applications and waiting to see whether a papilloma develops later on. 6 - The advisability of securing the services cf a full-time research worker who could not only direct research on problems designated by the A.F.I., but also run tests for individual conroanies on sazroles submitted by them. 7 - It was agreed that it would be up to the individual companies to decide how much each company wants to do on its own, with the understanding that they will be kept informed as to the nature of the A.?.I. work. %( 8 - It was agreed that it would be desirable to keep dis cussion within the Subcommittee on an informal basis so that each member could express his opinions freely without committing the company he represents. These discussions would serve as a basis for the Subcommittee's formal report, \iiich would be limited to recommendations based on facts, rather than on mere opinions. 9 - The next meeting of the Subcommittee was set for 9 A.M., November 12th, at the Hotel Stevens in Chicago. 10 - Toward tile close of the meeting, agreement was reached among those present that it would be desirable to appoint Hr. H.G.H. FiBcher as Chairman of the Technical Group of the Subcommittee, with the understanding that he would call the technical advisers of the committee together to draw up physical and chemical specifications that mi^it distinguish fractions that are carcinogenic from those which are not. Then, to determine what refining processes produce such fractions and what samples should be obtained for further study and investigation. S?Af D. CHAIRMA5 API 04705 9 Not For Publication Copiea from D. V. Stroop for Information of Members and Associates of API Medical Advisory Committee September l6, I9U7 0O0 Minutes of Meeting of Subcommittee on Carcinogenicity September 9. 19^7 A special meeting of the Subcommittee on Carcinogenicity vas held at 26 Broadway, Nev York City on Tuesday, September 9th, 19^7- Those present vere Dr. T. M. Frank Dr. A. E. Hoag Dr. J. P. Holt Dr. T. J. Kelly Dr. M. N. Newquist Dr. McIver Woody Dr. L. C. Beard, Jr. Mr. R. S. Bonslb Mr. H. G. M. Fischer Mr. D. V. Stroop - Pan American Defining Corp. - Socony-Vacuum Oil Co., Inc. - Standard Oil Company (N.J.) - Shell Oil Company, Inc. - The Texas Company - Standard Oil Company of N.J. _ Socony-Vacuum Oil Co., Inc. Standard Oil Company (N.J.) - Standard Oil Development Co. - American Petroleum Institute Dr. Robert Clinton Page, Mr. H. P. Lankelma, and Mr. H. R. Warrick had written that they would not be able to attend. The minutes of the previous meeting were reviewed and amended as follows: Paragraph 1, (b), third line, "a eo-carclnogen and" should be "a co-carImogen or". Paragraph 2, (a), sixth line, "to have at least a structure" should read "to have a structure". In discussing heading No. 1, Mr. Fischer stated his reasons for recommending animal tests to determine the effect of different concentrations of methyl-cholacthrene dissolved in benzol as against the effect' of the same concentrations dissolved in white oil. He was inclined to think that at least five concentrations should be tested so that two curves could be drawn, one showing the effect of the concentrations in benzol and the other the effect of the same concentrations in white oil. Headings No. 3, b, 5 and 6 were discussed together and general agree ment was reached that the following questions should be Investigated: 1 - Effect of actinic rays on skin contaminated with the possible carcinogen. API 04706 d -2- * Hot For Publication 2 - Effect of washing with soap and water, or some other solvent, after application of carcinogen. 3 - The value of protective creams. 1* - Effect of varying the site of application by painting a given animal at a different spot each time. 5 - Effect of applying carcinogen for a certain number of times (12 weeks?), then discontinuing applications and waiting to see whether a papilloma develops later on. 6 - The advisability of securing the services of a full-time research worker who could not only direct research on problems designated by the API, but also run tests for individual companies on samples submitted by them. 7 - It was agreed that it would be up to the individual companies to decide how much each company wants to do on its own, with the understanding that they will be kept informed as to the nature of the API work. 8 - It was agreed that it would be desirable to keep discussion within the Subcommittee on an Informal basis so that each member could express his opinions freely without committing the company he represents. These discussions would serve as a basis for the Subcommittee's formal report, which would be limited to recannendatlona based on facts, rather than on mere opinions. 9 - The next meeting of the Subcommittee was set for 9 A.M., November 12th, at the Hotel Stevens in Chicago. 10 - Toward the close of the meeting, agreement was reached among those' present that it would be desirable to appoint __ Mr. H. G. M. Fischer as Chairman of the Technical Group of the Subcommittee, with the understanding that he would call the technical advisers of the committee together to draw up physical and chemical specifications that might distinguish fractions that are carcinogenic from those which are not. Than, to determine what refining processes produce such fractions and what samples should be obtained for further study and investigation. Mclver Woody. M.D. CHAIRMAN API 04707  * UNIVERSITY OF CINCINNATI CINCINNATI!. OHIO November 5 , 19^7 I . CABLE ADDRESS: KETLAB. CINCINNATI TELEPHONE: UNIVERSITY 2*15 Mr- Dav id V. Stroop, Director, Department of Safety, American Petroleum Institute, cq West 5uth Street, jfev York City 20. Dear Mr. Stroop: please accept my thanks for your letter of October 28 which completely clarifies matters from my viewpoint, in relation to the contribution of $250U.Uu on the part of the American Petroleum Institute, toward the development of information on fluorine and fluorine compounds (in accordance with our purposes as restated in your letter), for the period of twelve months immediately following your making of the contribution. I consider it entirely acceptable, that you should reconsider this matter as you desire, from year to year. It so happens that I shall be at the meeting of the Medical Advisory Committee in the Hotel Stevens on November 12, at which time details related to this matter can be discussed. Meanwhile I am authorized by the industrial sponsors of the project to Include your group among the sponsors. Therefore, this can be regarded as formal notification of the acceptance of your contri bution under the conditions set forth. in ^aeur letter. Very truly yours, RAE ef Dictated but not r e a d . C.C.: Mr. 3. C. Ogburn, Jr. Dr. A. S. Hoag 1 Or. Hobart A. Ethoe lettering Labaratcry OolTarait/ of Cincinnati Cincinnati, Obl October 20, lVf Saar Dootcr Xahoa: Ovla rafara to yocr nhang of lattar# vlth Doctor A. Z. Hong and to tha dlaonaaion at aaatlng of tha Ifcotltata'a Ifcdlcal Mrlmarj Cenaittee hald la Zaffalo an Aprii 26, l$b7 partala!m to the lnvaatlfation nov balng oandoetad by tha Sattarlag Inhoratory on tha beharior of flnarlna or flaoriaa inanimila la tha tanna orpaalna, alth tha purpooe of daralopl^ lnfaraatloa to tha and thatt (a) brtlnal axparta ahall ha ahla to atnto alth greatar daflaltanaaa ahathar ar net an aliatili allant la daa to flaoriaa ar flaoriaa ocnpoanda; and (b) Bungh aaltahlo phyaloal and lahcmtory axaalaa- tlcaa aad/ar aaltahlo dotacnlaatlaaa of anrlronaaatal eoniltlana, ladaatarlal h/claadata ahall fiai lt poaable to AlfPansntlata hataon aafa aod tmaafa Sta potroloon ladnafcry 1 latarootad la tha porpora of thla lnveatlgatlT* prajaet and tha Madloal Adriocry Canalttaa haa rvnnaannifiil that the IaatItata ahnald ofZOr a flnanelal oanhrlhatlaa to spedita and facilitate tha ianlnpont of iafornatioa m 1adnotai. Toor lottar of Saptanbar 25th otatao that tha ladaatrlal aponora of tha projaet vili aeloona aoch partlolpatlon hy tha Jnarlaan jata'slaan Swtltoto. tta Paola of tha latitata*# donatila nniaaartly voald dlffar la eharastar fToa that af tha athars la that va ara aaaila to dhll#ata aay aoa of nonaj aanaally aaar a pwlod of far jaara. Qnri'ently o r contrita* ticm voold lanVala aaly tha flood ana of #2,900 fv pipantitari darini a 12-aonth parlod 1-- (llataly follovlng tha doantlon. Tha qaoatlon of fnrthar donatieoa far aanaodlni jaara voold bava to ha daoldad la aneh lnatanoa aitar ocnelderatlcn aad raooanndntlan ty tha ZMtitata'a ladleal Adriaory Ccanlttaa. Xf thla haala of partlolpatlon la aooeptad hy tha bttnlac Zoharmtory and tha laiiuitrial grcnp of apoaanra, va ahall pay tha $2,500 to tha Tfcivaral^ of ClanInnati vpon fornai aotifioatlon af net acceptance. Tary trvly yoora, BTBsd ac j hadleal Adrlaory Coanlttaa API 04709 M N. N E W O U IS T . M .D MEDICAL DIRECTOR TH E TEXAS COMPANY 135 EA ST 4 2 "? S TR EET NEW YORK 17, N . Y. f n\ X \ * F -r - c v..^ X A O c t o b e r 7 3 , 1 9 " 7 ^ \ Voi )\ Mr. D. V. S t r o o p American Petroleum. Institute 0 W e s t 5 Ot'r. S t r e e t e u Y o r k , K e T.: Y o r k Dear Mr. Stroop: P l e a s e r e f e r to y o u r l e t t e r of O c t o b e r 3, 1 9 ^ 7 , to members of the Medical Advisory Committee. I c o n c u r in y o u r p r o p o s a l to s e n d to Dr. Xeh o e on October 2?th, the l e t t e r w h i ch you have formulated pertaining to the research program on fluorine and its compounds. Very truly yours, d i A m e r i c a n P e t r o l e u m In s t i t u t e 50 W EST SOth STREET NEW YORK 20, N. Y. Dr. Robert A. Kehoe Kettering Laboratory University of Cincinnati Cincinnati, Ohio October 28, 19^7 Dear Doctor Kehoe: This refers to your exchange of letters with Doctor A. E.. Hoag and to the discussion at meeting of the Institute's Medical Advisory Committee held in Buffalo on April 28, 19L7 pertaining to the investigation now being conducted by the Kettering Laboratory on the behavior of fluorine or fluorine compounds in the human organism, with the purpose of developing information to the end that: (a) Medical experts shall be able to state with greater definiteness whether or not an alleged ailment is due to fluorine or fluorine compounds; and (b) Through suitable physical and laboratory examina tions and/or suitable determinations of environmental conditions, industrial hygienists shall find it possible to differentiate between safe and unsafe degrees of absorption of or exposure to fluorine or fluorine compounds. The petroleum industry is interested in the purpose of this investigative project and the Medical Advisory Committee has recommended that the Institute should offer a financial contribution to expedite and facilitate the development of information as indicated. Tour letter of September 25th states that the industrial sponsors of the project will welcome such participation by the American Petroleum Institute. The basis of the Institute's donation necessarily would differ in character from that of the others in that we are unable to obligate any sum of money annually over a period of four years. Currently our contribu tion would include only the fixed sum of $2,500 far expenditure during a 12-month period Immediately following the donation. The question of further donations for succeeding years would have to be decided in each Instance after consideration and recommendation by the Institute's Medical Advisory Committee. If this basis of participation is accepted by the Kettering Laboratory and the industrial group of sponsors, we shall pay the $2,500 to the University of Cincinnati upon formal notification of such acceptance. * Very truly yours, DVS :d me: Medical Advisory Comnittee. D. V. Stroop API 04711 0 A m e r i c a n P e t r o l e u m In s t i t u t e 50 W E S T 50th S T R E E T N E W Y O R K 20. N. Y . October 3 19^7 To Members and Associates , Medical Advisory Committee Gentlemen: At meeting held in Buffalo on April 28 you voted that the American Petroleum Institute should contribute $2,500 to the work on fluorides which was being sponsored by an industrial group at the Kettering Laboratory of Applied Physiology, College of Medicine, University of Cincinnati, under the direction of Doctor Kehoe. You authorized Doctor Hoag to make the necessary arrangemsnts with Doctor Kehoe in the understanding that you would be informed on the detailed arrangements and be given an opportunity to comment on them before the contribution was made. For your consideration, we enclose copies of letters from Doctor Kehoe dated September 25, 19^7 and from Doctor Hoag dated May 8 and October 2, 19^7. Based upon the suggestions made in these letters, we have prepared a draft of letter to Doctor Kehoe which will be transmitted to him on October 27 unless objections or alternate proposals are received from you on or before that date. A copy of the draft is enclosed. If you desire to conEDent on it, please do so as promptly as possible. Very truly.yours, DVS :d Enes. D.. V. Stroop API 04712 3 if For Committee Consideration Only - Hot Far publication DRAFT OF L E n t e (To be transmitted, on October 27 in the absence of objection by Members or Associates of API Msdical Advisory Committee.) Dr. Robert A. Kehoe Kettering Laboratory University of Cincinnati Cincinnati, Ohio Dear Doctor Kehoe: This referB to your exchange of letters with Doctor A. E. Hoag and. to the diBcusBion at meeting of the Institute's Medical Advisory Committee held in Buffalo on April 28, 19^7 pertaining to the investigation now being conducted by the Kettering Laboratory on the behavior of fluorine or fluorine compounds in the human organism, with the purpoBe of developing information to the end that: , (a) Medical experts shall be able to state with greater definiteness whether or not an alleged ailment is due to fluorine or fluorine compounds; and (b) Through suitable physical and laboratory examina tions and/or suitable determinations of environmental conditions, industrial hygienists shall find it poBBlble to differentiate between safe and unsafe degrees of absorption of or exposure to fluorine or fluorine compounds. The petroleum Industry is interested in the purpose of this investigative project and the Medical Advisory Committee haB recommended that the Institute should offer a financial contribution to expedite and facilitate the development of information aB Indicated. Your letter of September 25th states that the industrial sponsors of the project will welcome such participation by the American Petroleum Institute. The basis of the Institute's donation necessarily would differ in character from that of the otherb ,in that we are unable to obligate any sum of money annually over a period of four years. Currently our contribu tion would include only the fixed sum of $2,500 for expenditure during a 12-month period immediately following the donation. The question of further donations for succeeding years would have to be decided in each instance after consideration and recommendation by the Institute's Medical Advisory Cccmittee. If this basis of participation 1b accepted by the Kettering Laboratory and the industrial group of sponsors, we shall pay the $2,500 to the University of Cincinnati upon formal notification of such acceptance. Very truly yourB, DVB:d D. V, Stroop API 04713 September 25, I9V 7 Dr. A. E. Hoag API Medical Advisory Committee Socony-Vacuum Oil Company, Inc. 26 Broadway New York City U 0 (C 0 P y) Dear Dr. Hoag: I have been somewhat embarrassed by the delays involved in obtaining full acceptance of the generous proposal of the API Medical Advisory Committee to take part in our project for the study of the behavior of fluorides in the p p '*TM*-1 organism. I have been particularly sorry that I could not reply promptly to your letter of September 10. As you may well appreciate the interruptions of summer vacations and of other activities of people in the several industrial organizations have made it difficult to get a decision arrived at and confirmed in writing. However, I am glad to be able to report to you that all of the industries represented in this project have welcomed the proposal of your Committee. There remains now only the question of the implementation. I am writing to Mr. O g b u m of Pennsylvania Salt Manufacturing Company, who has acted as the center of conmmlcation for the group of Industries. I am making certain suggestions and asking certain questions, which have to do actually only with the means of allocating the expenditures during the specific period of time. I shall let you know Just what the reaction of the group is on this score, but I think there need be no further delay in the formal entrance of your group into the project. , From my point of view the terms of the agreement entered into between ourselves and your group clarify the policies of the University and provide for the procedures of accounting, reporting, etc. There are certain additional details to be taken into account, but I see no reason for executing an additional agreement. Bather I should consider that an exchange of letters will take care of the situation adequately. Our agreements with the other organizations concerned in this project are made with each one individually, and there are certain slight differences in the wording here and there. However, the under standing is that we are to proceed on a program of experimentation, which is concerned primarily with the determination of the physiological behavior of fluorine compounds in the aniine.-) and human organism. Much of the work will be a continuation of our observations on human beings, and this work Is being expanded as rapidly as we can. The problem we are attempting to solve primarily is the effect of prolonged exposure to and absorption of Inorganic fluorine compounds. Insofar as our observations deal with Industrial employees, such observations will be carried out separately from the general experimental project, since they will be made at the request of a particular industrial organization, and will be financed by that organization Itself. Work done in the latter category will have certain confidential aspects related to the administrative and legal responsibilities of such a company with reference to its own employees. Reports are to be made from time to time as the results of the experimental program may Justify, and In any case an Annual report of work done is to be made. At the end of the project a report that Is complete in every respect is to be made available to the sponsors. The account of all expenditures is to be made to each participant in the project, and the cost is to be allocated by u b against each participant on the basis o f the total sum involved and the agreed upon share of the individual participant in the project. API 04714 Dr. A. E. Hoag - September 25, 19^7 -2- I am sending you herewith, for the sake of simplicity a copy of one of the agreements for the consideration of your group. Meanwhile I should obtain the suggestions of the other group as to the means of allocating the cost. There is one point in this respect on which I am not clear. You will note that the duration of the project as agreed upon by the other sponsors is four years. I am not sure whether your group has made or1 intended to make a commitment for this period of time. It would simplify matters from the point of view of allocating costs if this were to be settled, if indeed it can be settled by your group at this time. For my own part I take this means of welcoming the interest of your group in this problem and its participation in it. I feel quite sure that we Bhall find this further relationship to be pleasant, and I trust it will be mutually profitable. Cordially yours, RAE ef /s/ Robert A. Eehoe Robert A. Eiehoe, M. D. CC: Mr. I. V. Stroop Mr. S. C. Ogburn, Jr. Et c . P.w. It may well be necessary, or at least advisable from time to time for some representative of your group to meet with the other sponsors of this work, ihen matters of general and mutual Interest are up for discussion. Such meetings will be arranged for either through me or directly with Mr. S. C. Ogburn, Jr. of Pennsylvania Salt Manufacturing Company, 1000 Widener Building, Philadelphia 7. It will be advisable to have Borne person or persons designated to receive correspondence, reports and the like. Therefore, your instructions in this matter Bhould be transmitted to me at your early convenience. API 04715 Made this day of THIS AGREEMENT 19^7 "between i (C 0 P I) (herein called "the donor"), and the UNIVERSITY OF CINCIMATI, (hereinafter called "the University") WITNESSETH WHEREAS, wishes the Kettering Laboratory of Applied Physiology (hereinafter called "the Laboratory") to investigate the "behavior of fluorine or fluorine compounds in the human . organism, with the purpose of developing information to the following ends; (a) that medical experts shall "be able to state with greater definitiveness whether or not an alleged ailment is due to fluorine or fluorine compounds; and (b) that through suitable physical and laboratory examinations, and/or suitable determinations of environmental conditions, industrial hygienists shall find it possible to differentiate between safe and unsafe degrees of absorption of or exposure to fluorine or fluorine compounds; and WHEREAS, the University approves of such investigative work by said Laboratory, In consideration of the mutual premises hereinafter specified, IT IS AGREED: . 1. The Laboratory shall take full responsibility for and carry out such investigations within the limits of its available facilities and scientific interests over the period of four years beginning in January 19^7. 2. The Donor shall pay to the University therefore the sum of per year, over the four-year period, payable annually or quarterly in advance. 3. The Laboratory shall render an accounting for all of its expenditures in connection with this work at the end of each calendar year, and at the end of the fourth year shall refund to the Donor any balance of funds that may remain of those advanced during the entire period. Funds in excess of those advanced during the four-year period, may not be expended, without the written consent of the Donor. h. Any and all materials, chemicals and equipment purchased by the Laboratory out of funds advanced for the pursuance of this project and remaining after the termination of the project or of the four year period specified herein, shall remain the property of the Laboratory. 5. The "WfflA of the University or of the Laboratory, or of any member, officer or employee of the Laboratory or the University shall not be used in any advertising matter at any time during the prosecution of the work or thereafter. API 04716 I - 2- i 6. Written reports of the findings of the Laboratory shall he made at intervals Justified by the progress of the work, and, in any event, annually, and a final report complete in all respects is to be issued upon completion of the project or of the four-year period specified. JVom time to time, when mutually convenient, representatives of the Donor and of the Laboratory i confer on the progress of the work. 7. The Donor may use interim reports of the Laboratory or photostatic copies thereof, as evidence of the facts established, and if the findings are published in scientific Journals, the Donor shall be free to quote such findings subsequent to their publication. 8. The Investigative work shall be planned and carried out by the University, and the University shall have the right to disseminate for the public good, any information obtained. However, before the issuance of public reports or scientific publications, the manuscripts thereof will be submitted to the Donor for criticism and suggestions. Confidential information obtained from the Donor shall not be published without permiBBion of said Donor. 9. The Donor shall have the right, without further payment whatever, to make use of all information, methods, devices, knowledge and practical applications of knowledge developed in the course of the work on this project. No person connected with the Laboratory or the University shall be required to make an application for patent based on any invention, discovery or development resulting from any investigative work under this agreement. The purpose and policy of the Laboratory and of the University, with respect to inventions, discoveries or developments relating to medicine, therapeutics or hygiene, is to discourage the acquisition of patents by the staff of the Laboratory, except when the control provided by the patent rights appears to be necessary or desirable in relation to the public welfare; and in any case, the Laboratory and University seek and will accept no financial reward from such patent. On the other hand, the right of absolute ownership by a member of the staff of the Laboratory, of hiB own invention, discovery, writing, creation or development is recognized by the University as indefeasible, excepting as same specific agreement in writing has been executed between staff members and the University, provided, however, that the Donor Shall have the right stated in the first clause of this paragraph to use all information, methods, devices and practical applications of knowledge developed in the course of the work on this project, without further payment. Ho such agreement obtains at present or is desired by the University. Should any patent be obtained in connection with the work of this project the University will seek by every proper means to affect a fair and mutually acceptable agreement between the member or members of the Laboratory staff involved, the University, and the Donor. HI WITNESS WHEREOF, the parties hereto have executed this Agresltaent by their proper officers respectively, who are hereby certified to have been duly authorized to execute the same. t By. UNIVERSITY OF CINCINNATI through its Board of Directors API 04717 3 (C 0 p Y) 1 May 8, 19^7 Dr. Robert A. Kehoe Kettering Laboratory University of Cincinnati Cincinnati, Ohio API Medical Committee Subcommittee on Fluorides Dear Dr. Kehoe: Following your presentation to the API Medical Committee at their meeting held in Buffalo on April 28, it was approved in principlo for the API to contribute $2,500 for the coining year to the Kettering Institute for studies on fluorides. It is intended that this money shall supplement the work already sponsored with the Kettering Laboratories by the Industrial Group (Pennsylvania Salt, Reynolds Metal, The Aluminum Company of America, du Pont and Universal Oil Products). It is further understood that this grant carries with it access to such data as you have obtained for the Industrial Group which is of a fundamental nature and does not deal specifically with industrial problems of a confidential nature peculiar to some member of said group. It is also assumed that the API Subcommittee on Fluorides would receive sympathetic consideration by the Industrial Group of suggestions regarding the course of the work so long as said suggestions do not ontail an entirely new method of attack. The API Medical Advisory Committee, at the meeting of reference, authorized me to proceed with negotiations along the above line and to this end, I would appreciate it if you would approach the Industrial Group and obtain their reaction to this proposition. If their reaction is favorable, the nert step would then be for you to prepare a memorandum of agreenent between the Kettering Laboratory and the American Petroleum Institute along the same general linos as that in effect now for the work on carcinogenicity. I would appreciate it if you would carry through the above and reply to me with a copy to Mr. D. V. Stroop, in order that Mr. Stroop may take the matter up with the officials of the API and determine that the procedure and form of agreement are in accord with their existing policies. Again, permit me to thank you and Ur. Heyroth for explaining this matter to us at the meeting. Very truly yours, JsJ A. E. Hoag A. E. Hoag, M.D. Mr. D. V. Stroop Mr. W. R. Levis Dr. F. F. Boys Dr. Kieffer Davis Dr. B. 3. Reeve Dr. M. N. Newquist Mr. L. C. Beard, Jr. Mr. Nelson J. Gothard Mr. R. C. Cole Mr. E. W. Adams API 04718 (C 0 P Y) 3 1 SOCONY-VACUUM O U COMPANY, INC. 26 Broadway N ew York 1*, N. Y. October 2, I9U7 Mr. D. V. Stroop American Petroleum Institute 50 West 50th Street New York, N.Y. Pear Mr. Stroop: API Medical Committee Subcomnil ttee on FluoridsB Confirming the telephone conversation of Mr. L. C. Beard, Jr. with you on October 1, 19^7> we attach a copy of our letter of May 8, 19**7 to Dr. Robert A. Kehoe clearly outlining to him how far the API was prepared to go in the natter of contributions to the University of Cincinnati for research on Fluorides. You have already received a copy of Dr. Kehoe's letter of September 25, 19^7 in this respect, but Hr. Kehoe failed to attach to your copy a copy of a proposed agreement which is the agreement the University of Cincinnati now have with the Industrial Group referred to in our letter of May 8, I9V 7. We hasten to send you herewith a copy of this form of agreement. As we understand, API polioy and such authorization as we have (subject to letter ballot approval) from the API Medical Committee, API can only commit themselves to year-by-year contributions and in this specific case to a sum not to exceod $2,500 for that year following execution of the agreement. f In order to expedite this matter it might be in order if you can find the time to do so, to draw up an agreement along the lines suggested by the attachment to Ur. Kehoe's letter of September 25, 19^7 and insert under Item 2, Page 1 the following: "The donor shall pay to the University, therefore, a sum not to exceed $2,500 for that year Immediately following execution of the agreement." Item 3, Page 1 provides for a redistribution to the donor of any unexpended funds after four years. This work does not fit well into API procedure. However, since the contributions by the other members of the Industrial Group are larger each year than the $2,500 vs are offering, it seems to us that it would be in order to stipulate a return of unexpended funds to the API at the end of a year only in the event that the amount contributed by any other donor to the project and expended was less than $2,500. In other words, API by their modest contribution is. getting the benefit of greater sums spent by other members of the Industrial Group and in our opinions should not be entitled to a pro rata Bhare of unexpended funds unless other members of the Group actually spent less than $2,500. You could then send this prepared agreement with a short covering letter to the members of the API (subject to letter ballot approval) or alternatively send it . to Dr. Kehoe for his acceptance and then submit it to the members of the API Committee, whichever procedure in your opinion seems preferable. We stand ready to assist you in any manner we can in this correspondence, but when it comes to matters of contracts, there is a little doubt in our mind as to how far our prerogatives in that respect extend. Please 1st us have your early advice in this matter, as we would like to get this whole thing cleared up prior to the API Medical Meeting in November. Very truly yours, AEH:DMM Enc. /a/ A. E. Hoag A. E. Hoag, M.D __rKflJrwon _ F.A.C.S. API 04719 1 1 September 25, 1^47 Dr. A . S Hoag, * A.f.I. Medical Advisory'Committee, Socony-Vacuum Oil Company, 26 Broadway, Sev York City 4. Dear Dr. Hoagi A I have been somewhat embarrassed by the delays l^aviilved in obtaining full acceptance Of the generous proposal of the A.Pul. Medioal Advisory Committee to take part.in our project for the study of the behavior of fluorides in the animal organlsffr^X^ave peen particu larly sorry that 1 oould not reply pramptXy^to your letter of September 1 j . A s you may well appreciate the"tarunions of summer vacations and of other activities of p e o p l e r n tbe several industrial organizations have made lk"3Iiflcult to ge\a/decislon arrived at and confirmed in writing'. However, I am glam to be able io report to you that all of the ndy4trleB\repreBented in this project have welcomed the proposal ml youk* Committee. There remains now only the question of the Implementation/; X am writing to Mr. Ogburn of Pennsylvania Salt Manurhnturing/Company, who has acted as the center of communication for thosgroi of industries. I am making certain uggestiona''afcMaskln\oeivUin questions, whloh have to do actually only vltjr the moqns of allobating the expenditures during the specific p ^ i o ^ o K t u S e . I sh^ll let you know just what the reaction of the group is a a this soore, but I think there need be no further delay in the formal entrance o r your group Into the projeot. N. y J from my point/df'^ev theStenwriof/the agreement entered into between ourselves and yam- group clarify the policies of the University and provide tojr thir phkoednres of'Tiscounting, reporting, etc. There are certain additional details to be taken into account, but I tee no reason f o A executing>qnAdditional agreement, iiathar I should consider tn^t eTche^e] of letters will take pare of the situation adequately. N^ur^agre^murta with the other organizations concerned 'in this projecV^ars^made with each one individually, and there are certain alight clgfefences in the wording here and there. However, the understanding T J i h a t we are to proceed on a program of experi mentation whloh is concerned primarily with the determination of the physiological behavior offluorine compounds in the animal and human organism. Much of the work will be a continuation of our observations on human beings, and this work is being expanded aa rapidly aa we can* The problem we are attempting to solve primarily is the effect of prolonged exposure toTsbiorption of inorganic fluorine compounds. Insofar as our observations deal with industrial employees, such observations will be oarrled ou: separately from the general experi ment* l project, since they will be made at the request of a particular API 04720 1 I r . A. S. Koag - (2) - September 2 5 , 1947 industrial organization, and will be financed by that organization itself* Work done in the latter category will have certain confidential aspects related to the- administrative and legal respon sibilities of such a company with reference to its own employees. Reports are to be made from time to time as the results of the `experimental program may justify, and in any case an annual report of work done is to be made. At the end of the project a report that is complete in every respeot is to be made available to the sponsors. ihe account of all expenditures is to be made to(each participant in the project, and the cost is to be allocated by us against each participant on the basis of the total sum involved a^d the agreed upon share of the individual participant in^tE^o; I am sending you herewith, for the sake of simp! ^opy of one of the agreements for the consideratloa-nf vour grout jShVhile" I should obtain the suggestions of $ne other group as \q/the means of allocating the cost. There is ahe n s d n t M m this respect on which I am not clear. You will note tfrat the dyraplon of the project as agreed upon by _the other spanso rs . T"am n o t 'sure whether your group "has made or ' ke a commitment for this period of time. It would s iters from the point of view of allocating costs l^s-this wer' be settled, if indeed it can be settled by your group a v this far' my own part I tajre group in this problem!an that we shall find th. trust it trill be mutua of weihdming the interest of your tihlpation in it. I feel quite sure a^lonship to be pleasant, and I ofitable. Cordially yours, kotier'tt A. Ketio*, M. t. rAK ef C.C.: Mr. D . Mr. 5. C. O g b u m , Jr. Enc. ?. S. It may veil be neceaaary or at leaat advisable from time to __ ______ /our group to meet with the other sponsors of this werk, when matters of gemeral and mutual interest are up for discussion. Such meetings will be arranged for either through me or directly with Mr. S. C. O g b u m , Jr. of Pennsylvania Salt Manufacturing Company, I j j Videner Building, Philadelphia 7* It will be advisable to have some person or persons designated to receive correspondence, reports and the like. Therefore, your instructions in this matter should be transmitted to me at your arly convenience. API 04721 THIS AGREEMENT Made this day of 1947 between (herein- called "the donor"), and the UNIVERSITY OF CINCINNATI, (hereinafter called "the University") WITNESSETH WHEREAS, wishes the Kettering Laboratory of Applied Physiology (hereinafter called "the Laboratory") to investigate the behavior of fluorine or fluorine compounds in the hun&n organism, with the purpose of developing information to the following ends; - (a) that medical experts shall be able to state with greater definitiveness whether or not an alleged ailment is due to fluorine or fluorine compounds; and (b) that through suitable physical and laboratory examinations, and/or suitable determinations of environmental conditions, indus trial hygienists shall find it possible to defferentiate between safe and unsafe degrees of absorption of or exposure to fluorine or fluorine compounds; and v WHEREAS, the University approves of such investigative work by said Laboratory, In consideration of the mutual promises hereinafter specified, IT IS AGREED: 1. The Laboratory shall take full responsibility for and carry out such investigations within the limits of its available facilities and scientific interests over the period of four years beginning in January 1947. 2. The Donor shall pay to the University therefore the sum of per year, over the four-year period, API 04722 -2- payable annually or quarterly in advance. 3. Hie Laboratory shall render an accounting for all of its expenditures in connection with this work at the end of each calendar year, and at the end of the fourth year shall refund to the Donor any balance of funds that may remain of those advanced during the entire period. Funds in excess of those advanced during the four-year period, may not be expended, without the written consent of the Donor. 4. Any and all materials, chemicals and equipment purchased by the laboratory out of funds advanced for the pursuance of this project and remaining after the termination of the project or of the four year period specified herein, shall remain the property of the Laboratory. 4. Hie name of the University or of the Laboratory, or of any member, officer or employee of the laboratory or the University shall not be used in any advertising matter at any time during the prosecution of the work or thereafter. ' 6. Written reports of the findings of the Laboratory shall be made at intervals justified by the progress of the work, and, in any event, annually, and a final report complete in all respects is to be issued upon completion of the project or of the four-year period specified. From time to time, when mutually convenient, representatives of the Donor and of the Laboratory shall confer on the progress of the work. 7. Hie Donor may use interim reports of the Laboratory or photostatic copies thereof, as evidence of the facts Astablished, and if the findings are published in scientific journals, the Donor shall be free to quote such findings subsequent to their publication. API 04723 ` O 8. The investigative work shall be planned and carried out by the Dhiversity, and the University shall have the right to disseminate for the public good, any information obtained. However, before the issuance of public reports or scientific publications, the manuscripts thereof will be submitted to the Donor for criticism and suggestions. Confidential information obtained from the Donor shall not be pub lished without permission of said Donor. 9. The Donor shall have the right, without further payment whatever, to make use of all information, methods, devices, knowledge and prictical applications of knowledge developed in the course of the work on this project. Ho person connected with the laboratory or the University shall be required to make an application for patent based on any invention, discovery or development resulting from any investigative work under this agreement. The purpose and policy of the Laboratory and of the University, with rspect to inventions, discoveries or developments relating to medicine, therapeutics or hygiene, is to discourage the acquisition of patents by the staff of the laboratory, except when the control provided by the patent rights appears to be necessary or desirable in relation to the public welfare; and in any case, the laboratory and University seek and will accept no financial reward from such patent. On the other hand, the right of absolute ownership by a member of the staff of the Laboratory, of his own invention, discovery, writing, creation or development is recognized by the University as indefeasible, excepting as some specific agreement in writing has been executed between staff members and the University, provided, however, that the Donor ihan have the right stated in. the first clause of this paragraph to use all information, methods, devised and practical applications of API 04724 knowledge developed in the course of the work on this project, without further payment. No such agreement obtains at present or is desired by the Hiiversity. Should any patent be obtained in connection with the work of this project the University will seek by every proper means to affect a fair and mutually acceptable agreement between the member or members of the laboratory staff involved, the University, and the Donor. IN WITNESS WHEREOF, the parties hereto have executed this Agreement by their proper officers respectively, who are hereby certified to have been duly authorized to execute the same. By. UNIVERSITI OF CINCINNATI through its Board of Dirctors By__________________________ fiiairman 'By______________________ Clerk API 04725  S o co n y -Va c i t m Oil Company INCORPORA T E U 20 BR04DWAV N e w Y o r k 4,N.Y Ht . D. V. Stroop American Fetroleua 50 lest 60 Street New Toik, H. T. Institute October 2, 1947 A.P.I. Medical Committee Subconmn t.t on Fluorides Dear Mr. Stroops Confining the telephone conversation of Mr. L. C. Beard, Jr. with you on October 1, 1947, we attach a copy of our letter of May 8, 1947 to Dr. Robert A. Kehoe clearly outlining to him how far the A.P.I. was prepared to go in the matter of contributions to the University of Cincinnati for research on Fluorides. You have already received a copy of Dr. Kehoe1e letter of Sep tember 25, 1947 in this respect, but Dr. Kehoe failed to attach to your copy a copy of a proposed agreement which is the agreement the University of Cin cinnati now have with the Industrial Group referred to in our letter of May 8, 1947. We hasten to send you herewith a copy of this foni of agreement. As we understand, A.P.I. policy and such authorization as we have (subject to letter ballot approval) from the A.P.I. Medical Committee, A.P.I. can only commit themselves to year-by-year contributions and in this specific case to a sua not to exceed #2,500 for that year following execution of the agreement. In ozder to expedite this matter it might be in order if you can find the time to do so, to draw up an agreement along the lines suggested by the attach ment to Dr. Kehoes letter of September 25, 1947 and insert under Item 2, Page 1 the following: "Bie donor pay to the University, therefore, a sun not to exceed #2,500 for that year immediately following execution of the agreement." Item 5, Rage 2 provides for a redistribution to the donor of any unexpend ed funds after four years. This work does not fit well into A.P.I. procedure. However, since the contributions by the other members of the Industrial Group are larger each year the #2,500 we are offering, it seems to us that it would be in order to stipulate a return of unexpended funds to the A.P.I. at the end of a year only in the event that the amount contributed by any other donor to the project and expended was less than #2,500. In other words, A.P.I. by their modest contribution is getting the benefit of greater s m s spent by other ifr. D. V. Stroop i - 2- Oetober 2. 1947 members of the Industrial Group and in our opinions should not be entitled to a pro rata share of unexpended funds unless other members of the Group actual ly spent less than $2,500. You could then send this prepared agreement with a short cowering letter to the members of the i.P.I. (subject to lmtter ballot approval) or alterna tively send it to Dr. Kehoe for his acceptance and then submit it to the mem bers of the A.P.I. committee, whichever procedure in your opinion seems pre ferable . He stand ready to assist you in any manner we can in this correspondence, but when it comes tg matters of contracts, there is a little doubt in our mind as to how far our prerogatives in that respect extend. Please let us have your early advice in this matter, as we would like to get this whole thing cleared up prior to the A.P.I. Medical Meeting in Bovember. Very truly yours, Enclosures: 2 cc: Mr. L. C. Beard, Jr. Chairman API 04727 1 I \o \ May 8, 1947 Dr. Robert A. Kehoe Kettering Laboratory University of Cincinnati Cincinnati, Ohio A.P.I. Medical CqTM h Suhp.pnm-ittee on Fluorides Dear Dr. Kehoe: Following your presentation to the A.P.I. Medical Committee at their meet ing held in Buffalo on April 28, it was approved in principle for the A.P.I. to contribute $2,500 for the coming year to the lettering Institute for stidies on fluorides. It is intended that this money shall supplement the work already spon sored with the Kettering Laboratories by the Industrial Group (Pennsylvania Salt, Reynolds Metal, The Alaninua Company of America, du Pont and Universal Oil Products). It is further understood that this grant carries with it access to such data as you have obtained for the Industrial Group which is of a fundamental nature and does not deal specifically with industrial problems of a confidential nature pe culiar to some member of said group. It is also assuned that the A.P.I. Subcom mittee on Fluorides would receive sympathetic consideration by the Industrial Group of suggestions regarding the course of the work so long as said suggestions do not entail an entirely new method of attack. The A.P.I. Medical Advisory Comittee, at the meeting of reference, author ised me to proceed with negotiations along the above line and to this end, I would appreciate it if you would approach the Industrial Group and obtain their reaction to this proposition. If their reaction is favorable, the next step would then be for you to prepare a memoranda of agreement between the Kettering Laboratory and the American Petroleum Institute along the same general lines as that in effect sow for the work on carcinogenicity. I would appreciate it if you would carry through the above ani reply to me with a copy to Ir. 0. 7 Stroop, in order that Mr. Stroop may take the matter up with the officials of the A.P.I. and determine that the procedure and form of agreement are in accord with their existing policies. Again, permit me to thank you and Dr. Heyroth for explaining this matter to us at the meeting. . bcc: Mr. D. V. Stroop Dr. W. R. Levis Dr. F. F. Boys Dr. Kieffer Davis Dr. B. Reeve Dr. M. N. HewqtrLst Mr. L. C. Beard, Jr. Mr. Kelson J. Gothard Mr. R. C. Cole Mr. E. W. Adams 04728 API % *,N U iO W T O R Y DF APPLIED PHYSIOLOGY ' c0UU OF MEDICINE-- EDEN AVENUE i UNIVERSITY OF CINCINNATI CINCINNATI I*. OHIO November 22, 19^7 CABLE ADDRESS: KETLAB. CINCINNATI TELEPHONE: UNIVERSITY 2665 Mr. D. V. Stroop, The American Petroleum 50 V e s t 50th S t r e e t , jjev Y o r k C i t y 20. Company, Dear Mr. Stroop: I send you herewith for your information, an account of the expenditures made during the third quarter of 19^7 in connection vith the i n v e s t i g a t i o n of c a r c i n o g e n i c i t y . This, I b e l i e v e , is self explanatory. Cordially yours, Robert A . Kehoe, M . D . API 04729 % i UNIVERSITY OP CINCINNATI KETTERING LABORATORY OF APPLIED PHYSIODGY ACCOUNT OF THE AMERICAN PETROLEUM INSTITUTE For the Third Quarter of 1947 TARIES (Based on Proportion of Time Actually *2^ Spent on project) yrancis Heyroth Chemical and Toxicological Karl Kitiailler Pathological Assistance Ruby Hirose Louis de Lugo ya. Deichmann Chemical Assistance Rarold Schlecht Technical Assistance Sylvan Hitherup - M M Marjorie Christian Asst. r vT,T.ANEOUS E X P E N S E Laboratory Supplies proportion of Secretarial, Library, Janitors, Wash Boys, Draftsman, Shipping Clerks, Animal Care takers, Histopathological preparation etc . . proportion of Heat, Gas, Electricity, Steam, Gas, Telephone, Maintenance, Pensions, Annuities etc. ' 12.02 256.44 4.97 .96 46.29 62.69 78,00 30.67 492.04 4.45 207.63 101.80 805.92 Balance Remaining for Work in 1947 at End of Second Quarter 1947 ............... $2347- 58 Expenditures 3rd Quarter 1947 ............. 805.92 Balance Remaining for vork in 1947 . . . . $1541.66 API 04730  i A m e r i c a n P e t r o l e u m In s t i t u t e 3 0 W E ST SOTH ST R E E T NEW YORK 20. N. Y. November 28, 19^7 Dr. Robert A. Kehoe University of Cincinnati Kettering Laboratory of Applied. Physiology College of Medicine Eden Avenue Cincinnati 19, Ohio Dear Doctor Kehoe: In accordance with the understanding reached by our letters of October 28 and November 5 bo and from you, we are enclosing check in the amount of $2,500 payable to the University of Cincinnati as contribution towards the development of Information on fluorine and fluorine compounds. Very truly yours, DVS:d Enc. me: Dr. A. E. Hoag and Members Medical Advisory Conmittee V. R. Boyd, Jr. S. C. Qgbum, Jr. Lacey Walker D. V. Stroop API 04731 f |N LA V A T O R Y op a p pl ie d ph ysio lo g y ^ c o l .LESE 0F MEDICINE-- E0EN AVENUE UNIVERSITY OF CINCINNATI CINCINNATI I. OHIO D e c e m b e r 1, 1947 CABLE ADDRESS: KCTLAS. CINCINNATI TELEPHONE' UNIVERSITY Z l( $ Mr D V . S t r o o p , American P e t r o l e u m I n s t i t u t e , 50 West 5uth Street, New Y o r k City 2u. Dear Mr. Stroop: I herewith acknowledge with thanks receipt of American Petroleum Insti tute's check in' the amou n t of $ 25U.uo, c o vering their p o r t i o n of vork to be done on behalf of the Fluorine Project for 1948. Very truly yours, ef API 04732