Document M46kLb8vzb1p2rV5pLdy43BM7

'FERRUGINOUS BODIES" IN GUINEA PIGS-DAVIS ET Ah 373 other minerals may predominate and very few of these bodies be due to asbestos. A number of studies are at present being undertaken to recognize the mineral core of bodies found in unselected autopsies, but the examination of even one body is tedious and no definite results are yet available. The finding that the formation of elastin bodies is a process of impregnation rather than coating raises some interesting queries regarding the chemical processes involved in the formation of all types of ferruginous body. The impregnation of basement membranes by ferritin is a wellknown phenomenon,1 e and colloidal iron is used as a stain for acid mucopolysac charides.10-*0 It may be, therefore, that some iron-containing molecules have an affinity for certain proteins, and perhaps some mucopolysaccharides, and will se lectively impregnate aggregates of these materials. It has been known for a long time that asbestos body coating contained both iron and protein, but the discovery that granules very similar to ferritin con stituted the bulk of the coating material suggested that this iron-containing protein might make up the coating exclusively. One of us (J.M.G.D., 1965), however, showed that some layers of asbestos body contained little ferritin, and it may be that body formation involves initially the coat ing of the dust with a layer of protein or mucopolysaccharide containing no iron. Later, ferritin may impregnate this layer in a number of patterns to produce either single- or multiple-layered bodies. References 1. Fahr, and Feigel: Aerztlicher Verein In Ham burg, Mvnchen Med Wschr 61:625-626 (March) 1914. 2. Cooke, W.: Fibrosis of the Lungs Due to the Inhalation of Asbestos Dust, Brit Med J 2:147 (July) 1921. 3. Stewart. M.J., and HBddow, A.C.: Demonstra tion of the Peculiar Bodies of Pulmonary Asbestosis (Asbestosis Bodies) in Material Obtained by Lung Puncture and in the Sputum, J Path Baet 32:172 (Jan) 1929. 4. Gloyne, S.R.: The Asbestosis Body, Lancet 219: 1351-1353 (June) 1932 5. Beger, PJ.: Ober die Asbestosiskorperchen, Virchow Arch 290:280-333 (March) 1933. 6. Sundius, N., and Bygden. A.: Der Staubinhalt einer Asbestosislunge und die Beshaffenheit der sogenannten Asbestosis korperchen. Arch Geuierbepoth Gewerbehyp 8:26-34 (March) 1937. 7. Thomson, J.G.; Kaschula, R.O.C.; and Mac donald. R.R.: Asbestos as a Modem Urban Hazard, 5 Air Med J 37:77-81 (Jan) 1963. 8. Thomson, J.G.; Path, F.C.; and Graves, W.M.: Asbestos as an Urban Air Contaminant, Arch Path 81:438-461 (May) 1966. 9. Cauna. D.; Totten, R.S.: and Gross, P.: Asbestos Bodies in Human Lungs at Autopsy. JAMA 192:371373 (May 3) 1965. 10. Anjilvel, L., and Thurlbeck, W.M.: The Inci dence of Asbestos Bodies in the Lungs at Random Necropsies in Montreal, Canod Med Atioc J 95: 1179-1182 (Dec) 1966. 11. Utidjian, M.D.; Gross, P.; and de Treville, R.T.P.: Ferruginous Bodies in Human Lungs, Arch Environ Health 17:327-333 (Sept) 1968. 12. Gloyne, S.R.; Marshall, G.; and Hoyle, C.: Pneumoconiosis Due to Graphite Dust, Thorax 4: 31-38 (March) 1949. 13. Gross, P., el al: Pulmonary Ferruginous Bodies: Development in Response to Filamentous Dusts and a Method of Isolation and Concentration, Arch Path 85:539-346 (May) 1968. 14. Davis. J.M.G.: The Ultrastructure of Asbestos Bodies From Guinea Pig Lungs, Brit J Exp Path 45:634-641 (Dec) 1964. 15. Davis, JM.G.: The Ultrastructure of Asbestos Bodies From Human Lungs, Brit J Exp Path 45: 642-646 (Dec) 1964. 16. Gough, J.: Differential Diagnosis in the Pathology of Asbestosis, Ann NY Acad Set 132: 368-372 (Sept) 1965. 17. Collet A., end Reuet-Normand, C.: Aspects Infra-structuraux de la Traversee de la Paroi Alveolaire du Poumon par des Cellules Migratriees. Sem Hop Paris 43:1928-1937 (June) 1967. 18. Farquar, M.G., and Paladc, GJ2.: Glomerular Permeability: II. Ferritin Transfer Across the Glomerular Capillary Wall in Nephrotic Rats. J Exp Med 114:699-716 (Nov) 1961. 19. Curran. R.C.: Lovell, D.; and Clark, A.E.: Mucopolysaccharides in Peritoneal Granulomas in the Rat. J Path Bact 91:429-439 (April) 1966. 20. Roy, S.. and GhBdiBlIy, F.N.: Synthesis of Hyaluronic Acid by Synovia] Cells, J Path Bact 93: 555-557 (April) 1967. Arch Path--Vol 89, April 1970 8005 1457 PRODUCED BY FORD