Document M44jBakgjqdLjgob8BZpv0Z8y

1 lead to mesothelioma? Page 460 2 A Yes, sir. I think there is substantial 3 evidence that asbestos fibers cause chromosomal damage 4 and that chromosomal damage is an important part of 5 the process leading to the cancer and mesothelioma. 6 Q Have there been other studies, doctors, 7 that you have been familiar with where chrysotile 8 fibers have been used in such a study? 9 A Yes, sir. I mentioned Dr. Mark's study 10 where he showed a chromosomal damage, and there is a 11 Dr. Tom Hei, University of New York and he has 12 developed an assay looking for mutations in human 13 chromosomes and, again, has found chrysotile to cause 14 these types of changes. 15 Q Doctor, do you have an opinion, again, with 16 reasonable medical certainty as to whether exposure to 17 asbestos can cause other diseases in the human 18 respiratory tract? 19 A Yes, sir. Based on these types of studies 20 as well as the observations of large numbers of 21 mesotheliomas, people exposed to asbestos, as well as