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c 5. IflPLETE--NOT VERIFIED--11/10/76 6. L - 7. 8. APPENDIX A. HISTOPATHOLOGY - RATS .9. 10 12; INDIVIDUAL HISTOPATHOLOGY OF HALE RATS. COHTROI. HTNTR1 GROUP: 07-031H 13. NCI CONTRACT: 723278 HAZLETON 14. NCI CHEMICAL: C00511 1,2--DICHLOROETHANE 15. c c: ;t c: i i a 16. 17. 18. 29. .21 .22 23. 24. 25. 26. 27. 28. 29. WEEKS ON STUDY DISP ANIMAL CODE NUMBER TOPOGRAPHY TDHORS MORPHOLOGY 106 NATD 001 OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY CERVICAL LYMPH NODE LUNG KIDNEY LIVER MESENTERY PANCREAS TESTIS ----- INFLAMMATION PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC ------- ANGIBCTASIS PERIARTERITIS ~-------- PERIARTERITIS ATROPHY --------------------------- C c C 30. 31. 32. 33. 34. 35. 36. 37. 38. 101 NATD 002 ----- AORTA--------------------- PERICARDIUM ------MYOCARDIUM-- * 1 KIDNEY -- --------------- MESENTERY------------ PANCREAS TESTIS---------------------- -------- PITUITARY ---------- PARATHYROID MED IAL~ CALCIFICATION------------INFLAMMATION INFLAMMATION -----------------------------INFLAMMATION CHRONIC PERIARTERITIS------=------------------PERIARTERITIS ATROPHY-----------------------------------------ANGIBCTASIS HYPERPLASIA -------------------------------- Q 39. 40. 41. 42. 43. 44. 45. 46; 47. 48. 49. 50: 101 NATD 003 ------- AORTA--------HEART LUNG--------LUNG - --------- --------------KIDNEY--------------MESENTERIC ARTERY ---------------------------- STOMACH---------------------TESTIS ----------------------------- EPIDIDYMIS-----THYROID ----------------------------- PARATHYROID------------ MEDIAL"CALCIFICATION------------- CALCIUM DEPOSITION PNEUMONIA CHRONIC-MURINE-- CALdDM DEPOSITION. INFLAMMATION-CHRONIC--7:------ . MEDIAL CALCIFICATION ' . ' CALCIUM-DEPOSITION ATROPHY ATROPHY----------------- "---------------------. HYPERPLASIA FOLLICULAR-C $ ' HYPERPLASIA--------"-----------r -52v - 87 NATD -004 PITUITARY -- ------------ CHR OHOPROBE-ADENOMA------------------------------------ LONG------------------ c PNEUMONIA -CHRONIC MURINE -- 53. THYROID FOLLICULAR-CELL CARCINOMA LIVER INFLAMMATION 54-.-------------------------------- ADRENAL -CORTICAL-CARCINOMA------------------------------------- KIDNEY----------------------------- INFLAMMATION CHRONIC-------- -- 55. MAMMARY GLAND FIBROADENOMA TESTIS 56.- ------ ------------ - - --......................- - ' - --------- ----------------------------------------------------------------------------------------- EPIDIDYMIS..................... ATROPHY ATROPHY ---------------------------------- c; SL 068334 58. 59. 60. 61 . 62. 63. .6S . 66 .67. 68 PLETE -- NOT VEHIFIED-- 11/10/76 Iem > APPENDIX A. HISTOPATHOLOGY - HATS INDIVIDUAL HISTOPATHOLOGY OF HALE RATS.CONTROL fOSTRI NCI COHTEACT: 723278 HAZLETON NCI CHEHICAL: C00511 1,2-DICHLOROETHANE GEOtJP: 01-031H 69. REEKS ON DISP ANIHAL TOHORS 70. STUDY CODE 80HBER 71 . TOPOGRAPHY 73. 74. 475. 76. 106 TSAC 005 PITUITARY SHALL INTESTINE 77. 78. 79. 80. 81. & 106 TSAC 006 82. 83. 84. .85. 86 .87. 88 89. 78 NATD 007 *H0LTIPLE ORGANS 90. 91. 92. 93. 90 NATD 008 94. 95. 96. 97. 98. 106 TSAC 009 99. .100 .101 .102 86 NATD 010 103. 104. 105. 106. 107. 108. 76 NATD 011 .109. 110 m. .112 * HOLTIPLE TDHOR HORPHOLOGY CHROHOPHOBE ADENOHA FI5R0SARC0HA LEOKEHIA LYHPBOCYTIC OTHER PATHOLOGY TOPOGRAPHY HORPHOLOGY LUNG KIDNEY BILE DOCT TESTIS LONG KIDNEY BILE DUCT HYOCARDIDH HESENTERY PANCREAS TESTIS PROSTATE STOHACH PROSTATE THYROID ADRENAL CORTEX LONG KIDNEY LITER LONG KIDNEY BILE DUCT LONG KIDNEY LITER TESTIS EPIDIDYHIS LONG TESTIS KIDNEY PNEUHOHIA CHRONIC HURIHE INFLAHHATION CHHONIC HYPERPLASIA ATROPHY PNEDHONIA CHRONIC BURINE IHPLASHATION CHRONIC HYPERPLASIA DEGENERATION PERIARTERITIS PERIARTERITIS ATROPHY INFLAHHATION CALCIUH DEPOSITION INFLAHHATION DLTIHOBRANCHIAL CYST ANGIECTASIS PNEDHONIA CHRONIC HBEINE INFLAHHATION CHRONIC ANGIECTASIS PNEDHONIA CHRONIC HOHIHE INFLAHHATION CHRONIC HYPERPLASIA PNEDHONIA CHRONIC HORIBE INFLAHHATION CHRONIC ANGIECTASIS ATROPHY ATROPHY PNEDHONIA CHRONIC HDSINE ATROPHY INPLAHHATION CHRONIC r < c c c c c c ( c c c c c c c c f SL 068335 ( 113. 1 14. 115. 116. 117. 118. 139. 121. 122. 123. 1[ITMRPLETE -- HOT VERIFIED -- 11/10/76 APPENDIX A. HISTOPATHOLOGY - RATS INDIVIDUAL HISTOPATHOLOGY OF HALE RATS.CONTROL(HNTR) SCI CONTRACT: 723278 HAZLETON NCI CEEHICAL: C00511 1,2-DICHLOROETHANE GROUP: 01-031H 124. 125. 126. 128. 129. 130. 131 . 132. 133. 134. 135. 136. 137. 138. 139. 140. 141. 142. 143. 144. 145. 146. 147. 148. 149. 150. 151. 152. 153. 154. 155. 156. 157. 158. 159. 160. 161. -c*> WEEKS OH STUDY DISP AHIHAL CODE NUMBER TOPOGRAPHY TUHORS y 106 TSAC 012 ADRENAL <s> 61 SATD 013 89 NATD 014 SALIVARY GLAND HAHHARY GLAHD 57 SSAC 015 57 SSAC 016 MORPHOLOGY CORTICAL CARCINOHA CARCINOHA,NOS ADEN OCARCIHOHA '^ OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY ENDOCARDIOH LONG KIDNEY SKIN LONG BILE DOCT KIDNEY KIDNEY TESTIS PROSTATE SBHINAL VESICLE URINARY BLADDER PER ITONBUB LONG KIDNEY LIVER BBSENTER! PANCREAS TESTIS KIDNEY LONG THYROID LONG KIDNEY TESTIS TESTIS EPIDIDYMIS COLON HYPERPLASIA PNEOBONIA CHRONIC BORINS INFLA HS ATION CHRONIC INFLAHHATIOH PNEOBONIA CHRONIC BURINE HYPERPLASIA PYELONEPHRITIS CALCIOB DEPOSITION ATROPHY INFLAHHATIOH IHFLAHMATION INFLAHHATIOH INFLAHHATIOH PNEOBONIA CHRONIC BURINE INFLAHHATIOH CHROBIC HETAHORPHOSIS FATTY PERIARTERITIS PERIARTERITIS ATROPHY IHFLAHHATION CHRONIC PNEOBONIA CHRONIC HORINB OLTIHOBKAHCHIAL-CYST PHEUHONIA CHRONIC HORINE IHFLAHHATION CHRONIC ATROPHY SPERHATOGENIC GRANULOHA NECROSIS FAT NEHATODIASIS SL 68336 163 164 165 166 167 168 1B9 171 172 173 174. 175. 176. 173. 179. 180. 181 . 182. 183. 184. 185. 186. 187. 188. 189. 190. 191 . 192. 193. 194. 195. 196. 197. 198. FHPLETE--SOTVERIFIED -- 11/10/76 APPENDIX A. HISTOPATHOLOGY - RATS INDIVIDUAL HISTOPATHOLOGT OF HALE RATS.CONTROL fPHTRI NCI CONTRACT: 723278 HAZLETON NCI CHEHICAL: C00511 1,2-DICHLOROETHANE GROUP: 01-031H WEEKS ON STUDY DISP ANIMAL CODE NUMBER TOPOGRAPHY TUMORS MORPHOLOGY 57 SSAC 017 50 NATD 018 SUBCUT TISSUE 57 SSAC 019 57 SSAC 020 FIBROSARCOMA OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY LIVES KIDNEY EYE/LACRIHAL GLAND MYOCARDIUM PERICARDIUM THYROID SPLEEN LUNG PROSTATE PROSTATE LUNG METAMORPHOSIS FATTY INFLAMMATION CHRONIC INFLAMMATION INFLAMMATION INFLAMMATION HYPERPLASIA C-CELL HEHATOPOIESIS PNEUMONIA CHRONIC MURINE INFLAMMATION INFLAMMATION PNEUMONIA CHRONIC MURINE DISPOSITION CODES: ACCK: AUTO: MISS: MSAC: ACCIDENTALLY KILLED AUTOLYSIS HISSING MORIBUND SACRIFICE NATD: NATURAL DEATH SSAC: SCHEDULED SACRIFICE TSAC: TERMINAL SACRIFICE OTHR: OTHER V c c c c c C C c r c SL 068337 c C C ( c 199. .220010.. 202 203. 204. 206. 207. 208. 209. 210. 211. 212. 213. 215. 216. 217. 218. 219. .220 .221 .222 223. 224. 225. 226. 227. 228. 229. 230. 231. 232. 233. 234. 235. 236. 237. 238. 239. 240. 241 . 24 2. 243. 244. 245. 246. 247. 248. 249. 250. 251 . MPL5TS--NOT VERIFIED--11/10/76 APPENDIX A. HISTOPATHOLOGY - RATS INDIVIDUAL HISTOPATHOLOGY OF 3ALB RATS.CONTROL fVEHl NCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C00511 1,2 --DICH LOROETffANE GROUP: 01-071H WEEKS ON STUDY DISP ANIMAL CODE SOMBER TOPOGRAPHY TUMORS MORPHOLOGY 0 110 110 & TSAC 001 TSAC 002 PITOITARY PANCREATIC ISLETS CHROMOPHOBE ADENOMA ISLET-CELL ADENOMA 85 NATD 003 80 NATD 004 80 NATD 005 (3 110 TSAC 006 28 G> 110 NATD 007 TSAC 008 MAMMARY GLAND 54 NATD 009 53 NATD 010 50 NATD Oil 104 NATD 012 ADENOCARCINOMA OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY LONG PNEOMONIA CHRONIC HDBIHE LUNG KIDNEY BILE DOCT PNEOMONIA CHRONIC HOBIBE INFLAMMATION CHHONIC HYPERPLASIA LONG TESTIS KIDNEY PNEOMONIA CHRONIC MORINE ATROPHY INFLAMMATION CHRONIC KIDNEY TESTIS LONG INFLAMMATION CHRONIC ATROPHY PNEOMONIA CHRONIC RORINB TESTIS ATROPHY LONG S0BCOT TISSOE/LBG TESTIS PNEOMONIA CHRONIC HOHIBE ABSCESS ATROPHY HO LESION REPORTED LUHG KIDNEY SOBCDT TISSDE/GROIN PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC ABSCESS LONG PNEOMONIA CHRONIC RORINB LONG PNEOMONIA CHRONIC HORINE LONG EPIDIDYMIS PNEOMONIA CHHONIC HORINE NECROSIS FAT LONG KIDNEY PNEUMONIA CHRONIC HORINE INFLAMMATION CHRONIC (. C C c c c c c c. c c c c c $ c i c C c SL 068338 c 252 . 253. 25a. 255. 256. 257. 258. 260. 261. 262. 263. 264. 265. 263. 268. 269. 270. 271. 272. 273. 274. 275. 276. 277. 278. 279. 280. 281. 282. 283. 284. '285. 286. 287. 288. 289. 290. 291. 292. 293. 294. 295. 296. 297. 298. spinPLETE--HOT VERIFIED-- 11/10/76 S' iiVltaat-i'-i - - " ^ " APPENDIX A. HISTOPATHOLOGY - RATS INDIVIDOAL HISTOPATHOLOGY OF HALE RATS.CONTROLrTEHl NCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C00511 1,2--DICHLOROETHANE GRODP: 01-071M HEEKS ON STUDY DISP ARIHAL CODE NUMBER TOPOGRAPHY TUHORS MORPHOLOGY OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY 108 NATD 013 PITHITARY 37 NATO 014 53 NATD 015 71 NATD 016 69 NATD 017 83 NATO 018 52 NATD 019 61 NATD 020 CHROMOPHOBE ADENOMA LUNG TESTIS LUNG STOMACH STOMACH LONG LUNG TESTIS SPLEEN LITER LUNG KIDNEY LITER STOMACH MESENTERY PANCREAS TESTIS PNEUMONIA CHRONIC MURINE ATROPHY NO LESION REPORTED PNEUMONIA CHRONIC MURINE ACANTHOSIS HYPERKERATOSIS PNEUMONIA CHRONIC MURINE PNEUMONIA CHROHIC MURINE ATROPHY HEMATOPOIESIS METAMORPHOSIS FATTY PNEUMONIA CHROHIC MURIBE INFLAMMATION CHROHIC METAHORPHOSIS FATTY CALCIUM DEPOSITION PERIARTERITIS PERIARTERITIS ATROPHY DISPOSITION CODES: ACCK: ADTO: HISS: HSAC: ACCIDENTALLY KILLED ADTOLYSIS HISSING HORIBDND SACRIFICE NATO: NATDRAL DEATH SSAC: SCHEDBLED SACRIFICE TSAC: TERMINAL SACRIFICE OTHH: OTHER SL 068339 299. 300 . 301. 302. 303. 304. 306 i. 307. 308. 309. 310, 311. 312, 313. 315. 316. 317. 318. 319. 320. 321. 322. 323. 324. 325. 326. 327. 328. 329. 330. 331. 332. 333. 334. 335. 336. 337. 338. 339. 340. 341. 342. 343. h f, Xf^MPLBTE--HOT VERIFIED--11/10/76 E i*. - t* u '* " APPENDIX A. HISTOPATHOLOGY - RATS INDIVIDUAL HISTOPATHOLOGY OF HALE RATS.LOW DOSE HCI CONTRACT: 723276 HAZLETON NCI CHEMICAL: C00511 1,2-DICHLOROETHANE GROUP: 01-0728 WEEKS OH STUDY DISP ANIMAL TUMORS CODE NUMBER TOPOGRAPHY MORPHOLOGY 103 NATO 001 76 NATD 002 98 KATD 003 89 NATD 004 75 NATD 005 93 NATD 006 ABDOMINAL CAVITY SPLEEN 104 NATD 007 HEMANGIOSARCOMA HEMANGIOSARCOMA METASTAT OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY LUNG TESTIS KIDNEY BRAIN/HENINGBS LUNG KIDNEY TESTIS LUNG LUNG KIDNEY TESTIS SPLEEN LUNG TESTIS LUNG KIDNEY TESTIS LUNG KIDNEY STOMACH TESTIS PNEUMONIA CHRONIC MURINE ATROPHY PYELONEPHRITIS INFLAMMATION PNEUMONIA CHRONIC MURINE PYELONEPHRITIS ATROPHY PNEUMONIA CHRONIC BURXBE PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC ATROPHY HEMATOPOIESIS PNEUMONIA CHRONIC HURIHE ATROPHY PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC ATROPHY PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC ULCER FOCAL ATROPHY SL 068340 344 . ' 345. 346. 347. 348. 349. 358. 352. 353. 354. 355. 356. 357. 358. 360 . 361. 362. 363. 364. 365. 366. 367. 368. 369. 370. 371. 372. 373. 374. 375. 376. 377. 378. 379. 380. 381. 382. 383. 384. 385. 386. 387. 388. 389. 390. 391. 392. 393. 394. 395. 396. 71PLETE--(TOT VERIFIED 11/10/76 APPENDIX A. 9ISTOPATHOLOGY - RATS INDIVIDUAL HISTOPATHOLOGY OF HALE RATS.LON DOSE NCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C00511 1,2-DICHLOROETHANE GROUP: 01-072M WEEKS ON STUDY DISP ANIMAL CODE NUMBER TOPOGRAPHY TUMORS MORPHOLOGY OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY 97 NATD 008 89 NATD 009 77 NATD 010 STOMACH PANCREATIC ISLETS KIDNEY 35 NATD Oil SQUAMOUS CELL CARCINOMA ISLET-CELL ADENOMA LIPOMA 82 NATD 012 STOMACH HEMANGIOSARCOMA 95 NATD 013 PITUITARY CHROMOPHOBE ADENOMA THYROID FOLLICULAR-CELL ADENOMA SUBCUT TISSUE/BACK FIBROMA MAMMARY GLAND FIBROSARCOMA SPLEEN HEMANGIOSARCOMA MYOCARDIUM HEART AORTA PARATHYROID LUNG KIDNEY LITER STOMACH TESTIS PROSTATE PARATHYROID LUNG KIDNEY TESTIS SPLEEN LUNG TESTIS LUNG TESTIS ESOPHAGUS PERICARDIUM SPLEEN LUNG KIDNEY LITER LUNG TESTIS DEGENERATION CALCIUM DEPOSITION MEDIAL CALCIFICATION HYPERPLASIA PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC METAMORPHOSIS FATTY CALCIUM DEPOSITION ATROPHY CALCIUM DEPOSITION HYPERPLASIA PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC ATROPHY HEMATOPOIESIS PNEUMONIA CHRONIC MURINE ATROPHY PNEUMONIA CHRONIC MURINE ATROPHY INFLAMMATION INFLAMMATION HEMATOPOIESIS PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC METAMORPHOSIS FATTY PNEUMONIA CHRONIC MURINE ATROPHY SL 068341 397. 398. 399. 400. 401. 402. 409. 405. 406. 407. 408. 409. 410. 412. 413. 414. 415. 416. 417. 418. 419. 420. 421. 422. 423. 424. 425. 426. 427. 428. 429. 430. 431 . 432. 433. 434. 435. 436. 437. 438. 439. 440. 441. 442. 443. 444. 445. 446. 447. 448. 449. M :SBoMPLETE--NOT VERIFIED- -11/10/76 i ------- J APPENDIX A. HISTOPATHOLOGY - RATS INDIVIDOAL HISTOPATHOLOGY OF HALE RATS.LOW DOSE NCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C00511 1,2--DICHLOROETHANE GROOP: 01-072H WEEKS ON STDDY DISP ANIMAL TUMORS CODE NOHBEK TOPOGRAPHY MORPHOLOGY 84 NATD 014 89 5ATD 015 TONICA VAGINALIS SPLEEN LIVER 92 NATD 016 THYROID MESOTHELIOMA HEMANGIOSARCOMA HEMANGIOSARCOMA FOLLICOLAR-CELL ADENOMA l 110 TSAC 017 MAMMARY GLAND TONICA VAGINALIS ADENOCARCINOMA MESOTHELIOMA 92 NATD 018 MAMMARY GLAND ADENOCARCINOMA 63 NATD 019 55 NATD 020 87 NATD 021 S0BC0T TISSOE/BACE SPLEEN FIBROMA HEMANGIOSARCOMA 59 NATD 022 OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY LONG KIDNEY LIVER LIVER PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC METAMORPHOSIS FATTY ANGIECTASIS LONG STOMACH TESTIS PNEOHONIA CHRONIC MURINE OLCER FOCAL ATROPHY LONG KIDNEY PANCREAS PNEUMONIA CHRONIC BORINS INFLAMMATION CHRONIC PERIARTERITIS THYROID LONG KIDNEY TESTIS CYST PNEOHONIA CHRONIC BORINS INFLAMMATION CHRONIC ATROPHY LONG KIDNEY TESTIS PNEOHONIA CHRONIC BORINE INF LAHfl ATIOH CHRONIC ATROPHY LONG PNEOHONIA CHRONIC HBRIHE LONG/BRONCHOS ABSCESS PLEURA rSFLABSATION KIDNEY IHFLAHHATIOH CHRONIC MESENTERIC LTHPHHODE AHGIECTASIS - TESTIS LONG ATROPHY PNEOHONIA CHRONIC BORINE LONG KIDNEY TESTIS PNEOHONIA CHRONIC HORIHE IHFLAHHATION CHRONIC ATROPHY SL 068342 4 SC. 451. 452. 453. 454. 455. 459. 458. 459. 460 . 461. 462. 463. 463. 466. 467. 468. 469. 470. 471. 472. 473. 474. 475. 476. 477. 478. 479. 480. 481. 482. 483. 484. 485. 486. 487. 48B. 489. 490. 491. 492. 493. 494. ItO R 496. 497. 498. 499. 500. 501. 502. V 5HPLETE--H01T_.VERIFI ED-- 11/10/76 . .. L` U "* kw APPENDIX A. HISTOPATHOLOGY - RATS INDIVIDUAL HISTOPATHOLOGY OF KALE HATS.LOW DOSE SCI COSTSACT: 723278 HAZLETOB SCI CHEMICAL: C00511 1,2-DICHLOROETHANE GROUP: 01-0728 WEEKS OS STUDY DISP ANIMAL CODE NUMBER TOPOGRAPHY TUKORS MORPHOLOGY OTHBH PATHOLOGY TOPOGRAPHY MORPHOLOGY 55 NATD 023 69 109 NATD 024 NATD 025 TUNICA VAGINALIS SPLEEN MESOTHELIOMA HEMANGIOSARCOMA 99 NATD 026 STOMACH SQUAMOUS CELL CARCINOMA 89 NATD 027 SUBCUT TISSUE/GROIN FIBROMA 52 NATD 028 52 NATD 029 77 NATO 030 THYMUS 104 NATD 031 SQUAMOUS CELL CARCINOMA BRAIN/HENINGES LUNG TESTIS INFLAMMATION PNEUMONIA CHRONIC MURINE ATROPHY BONE HARROW METAMORPHOSIS PATTY MYOCARDIUM KIDNEY LUNG DEGENERATION INFLAMMATION CHRONIC PNEUMONIA CHRONIC MURINE LUNG KIDNEY LIVES LITER TESTIS PROSTATE MESENTERY PNEUMONIA CHRONIC MURINE * INFLAMMATION CHRONIC ANGIECTASIS PERIARTERITIS ATROPHY IHFLAHH &TIOH PERIARTERITIS SPLEEN LUNG LIVER KIDNEY STOMACH TESTIS HEMATOPOIESIS PNEUMONIA CHRONIC MURINE INFLAMMATION INFLAMMATION CHRONIC ULCER FOCAL ATROPHY LUNG PNEUMONIA CHRONIC MURINE LUNG PNEUMONIA CHRONIC MURINE LUNG KIDNEY PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC LUNG KIDNEY TESTIS PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC ATROPHY SL 068343 50 3. 504. 505. 506. 507. 508. 500. 511. 512. 513. 514. 515. 516. 518. 519. 520. 521. 522. 523. 524. 525. 526. 527. 528. 529. 530. 531. 532. 533. 534. 535. 536. 537. 538. 539. 540. 541. 542. 543. 544. 545. 546. 547. 548. 549. 550: 551. 552. 553. 1PLBTE--MOT VERIFIED--11/10/76 v`-' *' APPENDIX A. HI5TOPATHOLOGY - RATS INDIVIDUAL HISTOPATHOLOGY OF HALE RATS.LOW DOSE NCI CONTRACT: 723278 HAZLETON NCI CHEHICAL: C00511 1,2-DICHLOROETHANE GROOP: 01-072H WEEKS ON STUDY DISP ANIHAL CODE NOflBER TOPOGRAPHY TfJHORS HORPROLOGY OTHER PATHOLOGY TOPOGRAPHY HORPHOLOGY 80 NATD 032 82 NATD 033 96 NATD 034 89 NATD 035 73 NATD 036 STOHACH 51 NATD 037 77 NATD 038 SPLEEN 82 NATD 039 HEHANGIOSARCOHA HEHANGIOSARCOHA LONG KIDNEY LUNG KIDNEY BILE DUCT ADRENAL ADRENAL CORTEX HYOCABDIUH LUNG KIDNEY KIDNEY STOHACH STOHACH LITER TESTIS LUNG KIDNEY TESTIS LUNG LUNG KIDNEY LUNG KIDNEY TESTIS LUNG KIDNEY PNEOHOSIA CHRONIC HURINE INFLAMRATION CHRONIC PNEUHOBIA CHRONIC NURXVE INFLAHH ATION CHRONIC HYPERPLASIA ANGIECTASIS DEGENERATION DEGENERATION PNEUHONIA CHRONIC HURINE INFLAHHATION CHRONIC PYELONEPHRITIS ACANTHOSIS HYPERKERATOSIS HETAHOHPHOSIS FATTY ATROPHY PNEUHONIA CHRONIC HURINE INFLAHHATION CHRONIC ATROPHY PNEUHONIA CHRONIC HURINE PNEUHONIA CHRONIC HURINE INFLAHHATION CHRONIC PNEUHONIA CHRONIC HURINE INFLAHHATION CHRONIC ATROPHY PNEUHONIA CHRONIC HURINE INFLAHHATION CHRONIC ( ( ( c c c c C: G c G C C C c c c G SL 068344 c c' O' 554 . 555. 556. 557. 558. 559. 560. 562. 563. 569. 565. 566. 567. 568. 570. 571. 572. 573. 579 . 575. 576. 577. 578. 579. 580. 581. 582. 583. 584. 585. 586. 587. 588. 589. 590. 591. 592. 593. 599. 595. 596. 597. 598. 599. 600. 601. 602. 603. 609. 605. I'^^^fcsPLETE-.-SOTrt IEBIFI ED--11/1 0/76 APPENDIX A. BISTOPATHOLOGY - RATS INDIVIDUAL BISTOPATHOLOGY OP BALE RATS.LOW DOSE NCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C00511 1,2-DICHLOROETHANE GROUP: 01-072H WEEKS ON ST0DY DISP ANIHAL CODE NUMBER TOPOGRAPHY TUMORS MORPHOLOGY OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY 102 KSAC 090 STOMACH HEMANGIOSARCOMA 61 NATD 041 65 NATD 042 99 NATD 043 39 NATD 044 77 NATD 045 75 NATD 046 SUBCUT TISSUE/GROIN PIBROMA 103 NATD 047 30 NATD 048 ADRENAL ADRENAL CORTEX LUNG KIDNEY TESTIS A NG IE CTAS IS DEGENERATION PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC ATROPHY LUNG PNEUMONIA CHRONIC MURINE LUNG KIDNEY PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC CERVICAL LYMPH LUNG KIDNEY TESTIS NODE INFLAMMATION PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC ATROPHY TRACHEA INFLAMMATION LUNG KIDNEY STOMACH PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC INFLAMMATION LUNG SUBCUT TISSUE PNEUMONIA CHRONIC MURINE ABSCESS TRACHEAL LYMPH NODE LUNG KIDNEY TESTIS SPLEEN LIVER STOMACH ANGIECTASIS PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC ATROPHY HEMATOPOIESIS METAMORPHOSIS FATTY ACANTHOSIS LUNG PNEUMONIA CHRONIC MURINE ( ,r Yr c; C c' c c c c c c c C- C C c /r SL 068345 C: C 606. 607. 608. 609. 610. 611. 612. 614. 615. 616. 617 6T8 619 629 622 623 624 625 626 627 628 629 630, 631 632 633 634 635 636 637 :>,1^PBP1.ETE--SOT VERIFIED --11/10/76 & APPENDIX A. HISTOPATHOLOGY - EATS INDIVIDUAL HISTOPATHOLOGY OF HALE RATS.LON DOSE SCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C00511 1,2-DICHLORORTHANE GROUP: 01-072H REEKS ON STUDY DISP ANIMAL CODE NUMBER TOPOGRAPHY TUMORS MORPHOLOGY OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY 81 NATD 049 SOBCOT TISSUE FIBROMA 74 NATD 050 SPLEEN PANCREAS HBHANGIOSARCORA HEMANGIOSARCOMA LUNG LIVER TESTIS PROSTATE URINARY BLADDER LUNG STOMACH STOMACH TESTIS PNEUMONIA CHRONIC BURINS METAMORPHOSIS FATTY ATROPHY INFLAMMATION INFLAMMATION PNEUMONIA CHRONIC BURINS ACANTHOSIS HYPERKERATOSIS ATROPHY DISPOSITION CODES: ACCK: AUTO: HISS: MS AC: ACCIDENTALLY KILLED AUTOLYSIS MISSING MORIBUND SACRIFICE . NATD: NATURAL DEATH SSAC: SCHEDULED SACRIFICE TSAC: TERMINAL SACRIFICE OTHR: OTHER SL 068346 638. 639. 640. 641. 642. 643. 64ft. 646. 647. 648. 649. 650. 651. 652. 654. 655. 656. 657. 658. 659. 660. 661. 662. 663. 664. .665. 666 .667. 668 669. 670. 671. 672. 673. 674. 675. 676. 677. 678. 679. 680. 681. 682. 683. 684. .685. 686 687. 688. 689. 690. 691. I^^HPLETE--NOT VERIFIED -- 71/10/76 i. ^ ,, ,, . - ------------ " ' APPENDIX A. HISTOPATHOLOGY - RATS INDIVIDOAL HISTOPATHOLOGY OF HALE RATS.BTGH DOSE NCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C005 11 1,2-DICHLOROETHANE GROUP: 01-073H REEKS ON STUDY DISP ANIHAL CODE NDM3ER TOPOGRAPHY T0HORS MORPHOLOGY OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY 9 NATD 001 22 NATD 002 16 NATD 003 74 NATD 004 34 NATO 005 73 NATO 006 83 HATD 007 *H0LTIPLE ORGANS 9 NATD 008 3 NATD 009 63 NATD 010 HEBANGIOSARCOBA 60 NATD 011 10 NATD 012 BONE BARRON PERICARDIBB LONG TESTIS LUNG KIDNEY LONG TESTIS SPLEEN LITER LONG LONG KIDNEY LONG TESTIS PROSTATE ORINARY BLADDER HEART HYOCARDIOH THYHOS ._ METABORPHOSIS FATTY NO LESION REPORTED NO LESION REPORTED INFLAHHATION PNEOHOHIA CHRONIC BURINE ATROPHY PNSDHONIA CHRONIC BURINS PYELONEPHRITIS PNE0HOHIA CHRONIC BORINE ATROPHY HEHOBEHAGE THROHB0S ORGANIZED PNEOHOHIA CHRONIC BORIHE PNEOHONIA CHRONIC H0RINB NO LESION REPORTED INFLABB ATION CHRONIC PNEOHOHIA CHRONIC BORINS ATROPHY INFLAHBATION INFLAHHATION NO LESION REPORTED THROHBOS ORGANIZED DEGENERATION ANGIECTASIS * MULTIPLE TUMOR SL 068347 692. 693. 694 . 695. 696. 697. 699. 700. 701. 702. 703. 704. 705. 70S. 708. 709. 710. 711. 712. 713. 714. 715. 716. 717. 718. 719. 720. 721. 722. 723. 724. 725. 726. 727. 728. 729. 730. 731. 732. 733. 734. 735. 736. 737. 738. 739. 740. 741. 742. 743i 744. 745. 746. IPLETE--NOT VERIFIED--11/10/76 .. .. -------- APPENDIX A. HISTOPATHOLOGT - HATS INDIVIDUAL HISTOPATHOLOGY OF BALE RATS.HTGH DOSE NCI CONTRACT: 723278 HAZLETON NCI CHEBICAL: C00511 1,2-DICHLOROETHANE GRODP: 01-073H WEEKS ON STUDY DISP ANIMAL CODE NUMBER TOPOGRAPHY TBBORS MORPHOLOGY OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY 15 NATD 013 71 NATD 014 STOMACH SUBCUT TISSUE 52 NATD 015 STOMACH 11 NATD 016 10 NATD 017 88 NATD 018 PITUITARY SQUAMOUS CELL CARCINOMA FIBROMA SQUAMOUS CELL CARCINOMA CHROMOPHOBE ADENOMA 59 NATD 019 STOMACH 76 NATD 020 SPLEEN PANCREAS 10 NATD 021 54 NATD 022 SQUAMOUS CELL CARCINOMA HEMANGIOSARCOMA HEMANGIOSARCOMA HTOCARDIDH MYOCARDIUM BONE BARRON HEART LUNG KIDNEY PROSTATE SEMINAL VESICLE LUNG KIDNEY HEART HEART AORTA LONG KIDNEY KIDNEY STOMACH LUNG KIDNEY TESTIS URINARY BLADDER ADRENAL ADRENAL CORTEX LIVER KIDNEY STOMACH LUNG TESTIS DEGENERATION FIBROSIS METAMORPHOSIS FATTY THROHBUS ORGANIZED PNEUMONIA CHRONIC MURINE PTELONEPHRITIS INFLAMMATION INFLAMMATION PNEUMONIA CHRONIC HUBINE INFLAMMATION CHRONIC THROMBUS ORGANIZED THROMBUS ORGANIZED MEDIAL CALCIFICATION PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC CALCIUM DEPOSITION CALCIUM DEPOSITION PNEUMONIA CHRONIC MURINE HYDRONEPHROSIS ATROPHY HYPERPLASIA EPITHELIAL ANGIECTASIS DEGENERATION ANGIECTASIS INFLAMMATION CHRONIC ULCER FOCAL PNEUMONIA CHRONIC BUSINS ATROPHY SL 068348 747. 748 . 749. 750. 751. 752. 758. 755. 756. 757. 758. 759. 760. 763. 763. 764. 765. 766. 767. 768. 769. 770. 771. 772. 773. 774. 775. 776. 777. 778. 779. 780. 781. 782. 783. 784. 785. 786. 787. 788. 789i 790. 791. 792. 793. 794. 795. 796. 797. 798. 799. 800. 801. IHPLETE--NOT VERIFIED--11/10/76 'S'--' APPENDIX A. HISTOPATHOLOGY - RATS INDIVIDUAL HISTOPATROLOGY OF MALE NCI CONTRACT: 723278 EAZLETOH BATS.HIGH DOSE NCI CHEHICAL: C00511 1,2-DICHLOBOETHASE GROUP: 01-073H WEEKS ON DISP ASTRAL STUDY CODE NOMBER TOPOGRAPHY ____________ ____ ____ - -------- TOHORS MORPHOLOGY 68 NATD 023 KIDNEY TOBOLAR-CBLL ADENOMA SOBCOT TISSOE/GROIN FIBROMA HOLTIPLE ORGANS HEHANGIOSAHCOHA 10 NATD 024 33 NATD 025 74 NATD 026 STOMACH KIDNEY SPLEEN 51 NATD 027 STOHACH 33 NATD 028 SQOAMOOS CELL CARCINOMA TOBOLAR-CELL ADENOCARCINOMA HBBANGIOSARCOMA SQOAMOOS CELL CARCINOMA 62 NATD 029 33 NATD 030 48 HATD 031 78 NATD 032 PANCREAS ADRENAL HEHARGIOSARCORA HERANGIOSARCOHA HSTASTAT OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY TESTIS LIVER LONG LONG LONG ATROPHY INFLAMMATION PNEOHONIA CHRONIC HORIME NO LESrOB REPORTED PNEUMONIA CHRONIC HORINE PNEOHONIA CHRONIC HORINE LONG LONG KIDNEY SPLEEN ADRENAL ADRENAL CORTEX STOMACH TESTIS ORINARY BLADDER SKIN OF BACK SOBCOT TISSDB LONG KIDNEY LONG SPLEEN LONG KIDNEY KIDNEY LIVER PNEOHONIA CHRONIC HORINE PNEOHONIA CHRONIC HORINE INFLAHHATION CHRONIC HER ATOPOIESIS ANGIECTASIS DEGENERATION HYPERKERATOSIS ATROPHY INFLAHHATION INFLAHHATION ABSCESS PNEDMONIA CHRONIC HORINE INFLAERATION CHRONIC PNEOHONIA CHRONIC HORINE HEMATOPOIESIS PNEOHONIA CHRONIC BOHINE INFLAHHATION CHRONIC CYST ANGIECTASIS * HOLTIPLE TOflOR SL 068349 ( r ( C C C c c c l s- c c f ( ( (' ( c c c Cl- o 302 303 SOU 805 806 807 808 810 811 812 813. 814. 815. 818. 818. .819. 8 20 821. 822. 823. 824. 825. 826. 827. 828. 829. 830. 831. 832. 833. 834. 835. 836. 837. 838. 839. 840. 841. 842. 843. 844. 845. 846. 847. 848. 849 ^ 850. 851. 852. 853. 854 . 855. 'HPLETE--NOT VERIFIED -- 11/10/76 .... l-j u Jii J ^ 't si 'a t ti 14 APPENDIX A- HISTOPATHOLOGY - RATS INDIVIDUAL BISTOPATHOLOGY OF BALE RATS.SIGH DOSE NCI CONTRACT: 723278 HAZLETON NCI CHEHICAL: COOS 11 1,2-DICHLOROETHANE GROOP: 01-073B VEERS ON STUDY DISP ANIHAL CODE NUMBER TOPOGRAPHY TOHORS MORPHOLOGY OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY 74 61 58 57 68 41 37 10 63 15 20 101 NATO 033 SUBCUT TISSUE KIDNEY NATO 034 MULTIPLE ORGANS NATD 035 SHALL INTESTINE MULTIPLE ORGANS NATO 036 STOMACH LIVER PANCREAS SPLEEN NATD 037 STOMACH LIVER PITUITARY SPLEEN NATD 038 NATD 039 PITUITARY NATD 040 NATD 041 NATD 042 NATD 043 NATD 044 STOMACH SUBCUT TISSUE/BACK KIDNEY FIBSOHA HAMARTOMA HEHANGIOSARCOHA ADENOCARCINOMA ADENOCARCINOMA METASTATIC SQUAMOUS CELL CARCINOMA SQUAMOUS CELL CARCINOMA HETASTAT SQUAMOUS CELL CARCINOMA HETASTAT SQUAMOUS CELL CARCINOMA HETASTAT SQUAMOUS CELL CARCINOMA HEPATOCELLULAR CARCINOMA CHROMOPHOBE ADENOMA HEHANGIOSARCOHA CHROMOPHOBE ADENOMA SQUAMOUS CELL CARCINOMA FIBROMA LIPOSARCOMA LUNG LUNG LUNG KIDNEY TESTIS THYROID LUNG TESTIS PERITONEUM THYROID LUNG BONE BARRON LONG STOMACH LUNG LIVES LIVER TESTIS PNEUMONIA CHRONIC MURINE PNEUMONIA CHRONIC MURINE PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC ATROPHY CYST PNEUMONIA CHRONIC MURINE ATROPHY HEMORRHAGE HYPERPLASIA POLLICULAR-C PNEDMONIA CHRONIC MURINE METAMORPHOSIS FATTY PNEUMONIA CHRONIC MURINE ULCER FOCAL NO LESION REPORTED PNEUMONIA CHRONIC MURINE HYPERPLASIA ANGIECTASIS ATR OPHY * MULTIPLE TUBOR 8 56 . 857. 853. B59. 860. 861. 862. 864. .865. 866 867 868 869 870 872 873 874 875 876 877 878 879 880 881 882 883 884 885 886 887 888 889 890 891 892 893 894 895 898 897 898 899. 900. 901. 902. FbPLETE--NOT VERIFIED--11/70/76 APPENDIX A. HISTOPATHOLOGY - HATS INDIVIDUAL HISTOPATHOLOGY OF HALE RATS.HIGH DOSE NCI CONTRACT: 723278 HAZLETON NCI CHEHICAL: C00511 1,2-DICHLOROETHANB GROUP: 01-073H WEEKS ON STUDY DISP ANIHAL CODE NUMBER TOPOGRAPHY TUHORS MORPHOLOGY OTHER PATHOLOGY TOPOGRAPHT MORPHOLOGY 76 NATD 045 SOBCUT TISSUE/GROIN FIBROMA 72 NATD 046 8 NATD 047 78 NATD 048 THYROID KIDNEY STOMACH PANCREAS SPLEEN FOLLICULAR-CELL ADENOMA LIPOMA LEIOMYOSARCOMA LEIOMYOSARCOMA METASTATIC LEIOMYOSARCOMA METASTATIC 84 NATD 049 STOMACH SQUAMOUS CELL CARCINOMA PITUITARY CHROMOPHOBE ADENOMA ADRENAL CORTICAL ADENOMA SOBCUT TISSOE/AXILLA FIBROMA SUBCUT TISSUE/BACK FIBROMA KIDNEY LIPOMA 74 NATD 050 TESTIS LUNG LUNG LONG BILE DUCT TESTIS PARATHYROID LUNG LIVER LIVER STOMACH TESTIS PROSTATE STOMACH STOMACH ATROPHY PNEUMONIA CHRONIC MURINE PNEUMONIA CHRONIC MURINE HO LESION REPORTED PNEUMONIA CHRONIC MURINE HYPERPLASIA ATROPHY HYPERPLASIA PNEUMONIA CHRONIC MURINE ASGIECTASIS CYST ULCER FOCAL ATROPHY INFLAMMATION ACANTHOSIS HYPERKERATOSIS DISPOSITION CODES: ACCK: ACCIDENTALLY KILLED AUTO: AUTOLYSIS HISS: HISSING HSAC: HORIBDHD SACRIFICE NATD: NATURAL DEATH SSAC: SCHEDULED SACRIFICE TSAC: TER8INAL SACRIFICE OTHR: OTHER SL 068351 1374. 1375. 1376. 1377. 1378. 1379. 1380. 1382. 1383. 1384. 1385. 1386. 1387. 1389. 1390. 1391. 1392. 1393. 1394. 1395. 1396. 1397. 1398. 1399. 1400. 1401. 1402. 1403. 1404. 1405. 1406. 1407. 1406. 1409. 1410. 1411. 1412. 1413. 1414. 1415. 1416. 1417. 1418. 1419. 1420. 1421. 1422. 1423. 1424. 1425. 1426. MPLETE--SOT VERIFIED--11/10/76 P w. . ' ? n T R P APPENDIX B. HISTOPATHOLOGY - RATS IKDIVIDOAL HISTOPATHOLOGT OF FEMALE RATS.CONTROLfUKTRI SCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C00511 1,2-DICHLOROETHANE GROUP: 01-031F SEEKS ON STUDY DISP ANIMAL CODE NOHBER TOPOGRAPHY TUMORS MORPHOLOGY OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY 0 106 (S. 106 &| 106 79 106 (9 TSAC 001 TSAC 002 TSAC 003 NATD 004 TSAC 005 MAMMARY GLAND PANCREATIC ISLETS PITUITARY THYROID KIDNEY HEART PITUITARY ADENOCARCINOMA ISLET-CELL ADENOMA CHROMOPHOBE ADENOMA C-CELL CARCINOMA MIXED TUMOR MALIGNANT MIXED TUMOR METASTAT CHROMOPHOBE ADENOMA Q 106 TSAC 006 PITUITARY 106 TSAC 007 HAHMARY GLAND 106 TSAC 008 MAMMARY GLAND THYROID OVARY 0 106 106 TSAC 009 TSAC 010 PITUITARY THYROID PITUITARY CHROMOPHOBE ADENOMA FIBROADENOMA ADENOCARCINOMA C-CELL ADENOMA CTSTADENOCARCINOMA CHROMOPHOBE ADENOMA C-CELL CARCINOMA CHROMOPHOBE ADENOMA ADRENAL CORTEX LUNG ANGIECTASIS PHEBMOHIA CHRONIC MURINE LUNG PNEUHONIA CHRONIC MURINE PARATHYROID LUNG HYPERPLASIA PNEUHONIA CHRONIC MURINE LIVER/CENTRILOBULAR NECROSIS UTERUS HYDROMETRA MYOCARDIUM LUNG KIDNEY OTERUS/ENDOHETRIUH THYROID FIBROSIS PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC HYPERPLASIA CYSTIC HYPERPLASIA C-CELL LUNG KIDNEY PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC LUNG KIDNEY PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC AORTA LUNG KIDNEY UTERUS THYROID MEDIAL CALCIFICATION ~ PNEUMONIA CHRONIC MURINE CALCIUM DEPOSITION HYDROMETRA HYPERPLASIA C-CELL LUNG KIDNEY PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC LONG THYROID PNEUMONIA CHRONIC MURINE HYPERPLASIA C-CELL r c c c c c ( c c C: C C G C '<= C c SL 068352 c 14 27. 1428. 1429. 1430. 1431. 1432. 1438. 1435. 1436. 14 37. 1438. 1439. 1440. 144a. 1443. 1444. 1445. 1446. 1447. 1448. 1449. 1450. 1451. 1452. 1453. 1454. 1455. 1456. 1457. 1458. 1459. 1460. 1461. 1462. 1463. 1464. 1465. 1466. 1467. 1468. 1469. 1470. 1471 . 1472. 1473. 1474; 1475. 14 76. 1477. 1478. 1479; 1480. 1481. FMPLETE--KOT VERIFIED--11/10/76 APPENDIX B. BISTOPATHOLOGY - RATS INDIVIDUAL HISTOPATHOLOGY OP FEHALB RATS.CONTROLfHNTRI NCI CONTRACT; 723278 HAZLETON NCI CHEMICAL: C00511 1,2-DICHLOROETHAKE GROUP: 01-03 IP SEEKS OH STUDY DISP ANIMAL CODE NOMBER TOPOGRAPHY TUMORS MORPHOLOGY OTHER PATHOLOGY TOPOGRAPHY MOB PROLOGY 106 (B> g> 106 TSAC 011 TSAC 012 KIDNEY UTERUS 91 NATO 013 106 TSAC 014 HAMARTOMA HEMANGIOMA 106 dP 57 57 TSAC 015 SSAC 016 SSAC 017 LIVER PITUITARY KIDNEY 57 SSAC 078 57 SSAC 019 MAMMARY GLAND 57 SSAC 020 THYROID HEPATOCELLULAR CARCINOMA CHROMOPHOBE ADENOMA HAMARTOMA FIBROADENOMA C-CELL ADENOMA LUNG UTERUS LONG KIDNEY LUNG KIDNEY LUNG KIDNEY LIVER STOMACH STOMACH STOMACH LUNG THYROID HTEROS/ENDOMETRIUH LUNG LUNG ADRENAL CORTEX LUNG KIDNEY UTEBUS LONG KIDNEY ADRENAL CORTEX PHBUHOHIA CHRONIC MUHINE HYDSOMETHA PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC METAMORPHOSIS FATTY INFLAMMATION ACANTHOSIS HYPERKERATOSIS PHEOHONIA CHRONIC MURINE HYPERPLASIA C-CELL INFLAMMATION PKEUHONIA CHRONIC MURINE PNEUMONIA CHRONIC MURINE ANGIECTASIS PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC HYDSOMETHA PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC ANGIECTASIS DISPOSITION CODES: ACCK: AUTO: MISS: MSAC: ACCIDENTALLY KILLED AUTOLYSIS MISSING MORIBUND SACRIFICE NATO: NATURAL DEATH SSAC: SCHEDULED SACRIFICE TSAC: TERMINAL SACRIFICE OTHR: OTHER Si 683 53 { r ( c c c c ( c c c c c c c c c c c <: c 1482. 1483. 1484. 1485. 1486. 1487. 1488. 1490. 1491. 1492. i MPLETE--NOT VERIFIED-- 11/10/76 APPENDIX B. HISTOPATHOIOGT - RATS INDIVIDUAL HISTOPATHOLOGY OF FEMALE RATS .CONTROL fYEm NCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C00511 1,2-DICHLOROETHANE GROUP: 01-071F 1493. 1494 . 1495. 1498. 1498. 1499. 1500. 1501. 1502. 1503. 1504. 1505. 1506. 1507. 1508. 1509. 1510. 1511. 1512. 1513. 1514. 1515. 1516. 1517. 1518. 1519. 1520. 1521. 1522. 1523. 1524. 1525. 1526. 1527. 1528. 1529. 1530. 1531. 1532. 1533. 1534. 1535. SEEKS ON STUDY DISP ANIMAL TODORS CODE NUMBER TOPOGRAPHY 71 NATO 001 (9 & 82 110 110 79 110 NATD 002 TSAC 003 TSAC 004 NATD 005 TSAC 006 PITUITARY PITUITARY SUBCUT TISSUE/BACK PITUITARY 62 80 87 6> 110 75 NATD 007 NATD 008 NATD 009 TSAC 010 NATD Oil PITUITARY OVARY 110 26 P) no 80 TSAC 012 NATD 013 TSAC 014 NATD 015 PITUITARY MORPHOLOGY CHROMOPHOBE ADENOMA CHROMOPHOBE ADENOMA FIBROMA CHROMOPHOBE ADENOMA CHROMOPHOBE ADENOMA GRANULOSA-CELL TUMOR CHROMOPHOBE ADENOMA OTHER PATHOLOGY TOPOGRAPHY HOH PHOLOGY LUNG PNEUMONIA CHRONIC MURINE CERVICAL LYMPH NODE INFLAMMATION LUNG PNEUMONIA CHRONIC MURINE LUNG KIDNEY PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC LUNG KIDNEY PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC LUNG PNEUMONIA CHRONIC MURINE UTERUS LUNG INFLAMMATION PNEUMONIA CHRONIC MURINE LUNG PNEUMONIA CHRONIC MURINE LUNG PNEUMONIA CHRONIC MURINE LUNG PNEUMONIA CHRONIC MURINE LUNG PNEUMONIA CHRONIC MURINE LUNG BRAIN/HENINGBS LUNG KIDNEY LUNG LUNG PNEUMONIA CHRONIC MURINE INFLAMMATION PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC NO LESION REPORTED PNEUMONIA CHRONIC MURINE PNEUMONIA CHRONIC MURINE SL 068354 1536. 1537. 1538. 1539. 1540. 1541. 1543. 1544. 1545. 1546. 1547 1546 1549 1559 1552 1553 1554 1555 1556 1557 1558 1559 1560 1561 1562 1563 1564 1565 1566 1567 1568 1569 1570 1571 1572. 1573. 1574. 1575. BHPLSTE--NOT VERIFIED--11/10/76 APPENDIX B. HISTOPATHOLOGY - HATS INDIVIDUAL HISTOPATHOLOGY OF FEMALE RATS . CONTROL fVEHl NCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C00511 1,2-DICELOROETHANE GBO0P: 01-07IF WEEKS ON STUDY DISP ANIKAL CODE NUMBER TOPOGRAPHY TDHORS MORPHOLOGY OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY 69 NATD 016 110 & TSAC 017 100 NATD 018 90 NATD 019 PITUITARY 0 110 TSAC 020 PITUITARY CHROMOPHOBE ADENOMA CHROMOPHOBE ADENOMA SPLEEN LIVER LUNG ADRENAL COBTBX ADRENAL LUNG OVA RT LUNG STOMACH STOMACH LUNG ADRENAL ADRENAL CORTEX LUNG HEMATOPOIESIS INFLAMMATION PNEUMONIA CHRONIC HURIHE DEGENERATION AHGIECTASIS PNEUMONIA CHRONIC MURINE CYST PNEUMONIA CHRONIC MURINE ACANTHOSIS HYPERKERATOSIS PNEUMONIA CHRONIC MURINE ANGIECTASIS DEGENERATION PNEUMONIA CHRONIC KURINE DISPOSITION CODES: ACCK: ACCIDENTALLY HILLED AUTO: SUTOLYSIS KISS: HISSING HSAC: HOHIBOND SACRIFICE NATD: NATURAL DEATH SSAC: SCHEDULED SACRIFICE TSAC: TERMINAL SACRIFICE OTKR: OTHER SL 068355 1576. 1577. 1578. 1579. 1580. 1581. 1582. 1584. 1585. 1586. 1587. 1588. 1589. 1598. 1592. 1593. 1594. 1595. 1596 . 1597. 1598. 1599. 1600. 1601. 1602. 1603. 1604. 1605. 1606. 1607. 1608. 1609. 1610. 1611. 1612. 1613. 1614. 1615. 1616. 1617. 1618. 1619. 1620. 1621. 1622. 1623. 1624. 1625. 1626. 1627. 1628. 1629. 1630. f MPLETF--WOT VERIFIED--If/,10/76 i. - .-- u~U ti 4 APPENDIX B. HISTOPATHOLOGY - RATS ( ( INDIVIDUAL HISTOPATHOLOGY OF FEMALE RATS.LOW DOSE NCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: COOS 11 1,2-DICHLOBOETHANE GROOP: 01-074F WEEKS ON STODY DISP ANIMAL CODE NOHBBR TOPOGRAPHY TOMORS MORPHOLOGY 6> 110 HATD 001 PITUITARY MAMMARY GLAND SPLEEN CHROMOPHOBE ADENOMA FIBROADENOMA HE8A NGIOSARCOHA 93 NATD 002 SUBCOT TISSOE/BACK HEMANGIOSARCOMA 74 MSAC 003 SUBCUT TISSUE/NECK ADENOCARCINOMA PITUITARY CHROMOPHOBE ADENOMA 63 NATD 004 4 NATD 005 2 NATD 006 93 NATD 007 MAMMARY GLAND FIBROADENOMA 96 NATD 008 82 NATD 009 SALIVARY GLAND 2 NATD 010 98 NATD Oil WAHWARY GLAND SQUAMOUS CELL CARCINOMA FIBROADENOMA 71 NATD 012 51 NATD 013 OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY LUNG SKIN SKIN UTERUS PNEUMONIA CHRONIC MURINE ACANTHOSIS HYPERKERATOSIS INFLAMMATION LUNG PNEUMONIA CHRONIC HUBIRB UTERUS OVARY LONG INFLAMMATION INFLAMMATION PNEUMONIA CHRONIC MURINE LUNG PNEUMONIA CHRONIC MURINE LUNG PNEUMONIA CHRONIC MURINE NO LESION REPORTED LUNG KIDNEY PNEUMONIA CHRONIC MURINE PYELONEPHRITIS ADRENAL CERVICAL LYMPH NODE LUNG ANGIECTASIS INFLAMMATION PNEUMONIA CHRONIC MURINE LUNG PNEUMONIA CHROMIC MURINE LUNG PNEUMONIA CHRONIC MURINE ADRENAL ADRENAL CORTEX LUNG VAGINA ANGIECTASIS DEGENERATION PNEUMONIA CHRONIC INFLAMMATION MUBINE LUNG PNEUMONIA CHRONIC MURINE LUNG PNEUMONIA CHRONIC MURINE ( c ( ( ' ( ( c c ( ( ( t ( c * MULTIPLE TOMOR SL 068356 1631. 1632. 1633. 1634 . 1635. 1636. 1638. 1639. 1640. 1641. MPLETE--HOT VERIFIED--11/10/76 APPENDIX B. HI STOPS TftOLOGY - RATS INDIVIDUAL HISTOPATHOLOGY OF FEMALE RATS.LON DOSE NCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C00511 1,2-DICHLOROETHANE GROUP: 01-074F 1642. 1643. 1644. 1646. 1647. 1648. 1649. 1650. 1651. 1652. 1653. 1654. 1655. 1656. 1657. 1658. 1659. 1660. 1661. 1662. 1663. 1664. 1665. 1666. 1667. 1668. 1669. 1670. 1671. 1672. 1673. 1674. 1675. 1676. 1677. 1678; 1679. 1680. 1681. HEEKS ON ST0DY DISP ANIMAL CODE SOMBER TOPOGSAPHY TUMORS 83 SATD 014 95 HSAC 015 94 NATD 016 MAMMARY GLAND 2 NATD 017 96 NATD 018 MAMMARY GLAND S(9 109 83 TSAC 019 NATD 020 *HAHHARY GLAND 53 NATD 021 PITUITARY MORPHOLOGY FIBROADENOMA FIBROADENOMA FIBROADENOMA CHROMOPHOBE ADENOMA OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY ADRENAL ADRENAL CORTEX LONG KIDNEY ANGIECTASIS DEGENERATION PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC LONG KIDNEY STOMACH STOMACH DTER0S HTER0S PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC ACANTHOSIS PARAKERATOSIS INFLAMMATION ABSCESS LUNG PERICARDIUM PNEUMONIA CHRONIC MURINE INFLAMMATION BONE BARRON ESOPHAGUS PLEURA METAMORPHOSIS FATTY INFLAMMATION INFLAMMATION LUNG LIVER PNEUMONIA CHRONIC MURINE ABSCESS LUNG KIDNEY PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC ADRENAL LUNG KIDNEY ASGIECTASIS PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC PERICARDIUM LUNG LIVER/CBNTRILOBULAR LIVER INFLAMMATION PNEUMONIA CHRONIC MURINE DEGENERATION METAMORPHOSIS FATTY 1682. * MULTIPLE TUMOR f SL 068357 16d3. 1684 . 1685. 1686. 1687. 1688. 1689 .. 1691. 1692. 1693. 1694 1695 1696 1698 1699 1700 1701 1702 1703 1704 1705 1706 1707 1708 1709 1710 1711 1712 1713 1714 1715 1716 1717 1718 1719 1720 1721 1722 1723 1724 1725 1726 1727. 1728 1729 1730 1731 MPL2TE--SOT VERIFIED--!1/10/76 APPENDIX 3. HISTOPATHOLOGY - RATS INDIVIDUAL HISTOPATHOLOGY OF FBHALE RATS.T.OW DOSE NCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C00511 1,2-DICHLOROETHANE GROUP: 07-074F WEEKS ON STUDY DISP ANIHAL CODE NUMBER TOPOGRAPHY TUMORS HORPBOLOGY 82 NATD 022 74 NATD 023 LIVER ADRENAL 31 NATD 024 95 NATD 025 103 NATD 026 PITUITARY 70 NATD 027 72 NATD 028 HEPATOCELLULAR CARCINOHA CORTICAL CARCINOHA CHROMOPHOBE ADENOHA OTHER PATHOLOGY TOPOGRAPHY HORPHOLOGY BRAIN/HBNINGES ADRENAL MYOCARDIUH PERICARDIUH LUNG KIDNEY PANCREAS KIDNEY STOBACH STOHACH BONE HARROW LUNG STOHACH STOHACH STOHACH SKIN LONG KIDNEY UTERUS BONE HARROW LUNG PERICARDIUH HYOCARDIUH VAGINA LUNG INFLA HH ATION ANGIBCTASIS INFLAHHATION INFLAHHATION PNEUHOHIA CHRONIC PYELONEPHRITIS INFLAHHATION HURINE INFLAHHATION CHRONIC ACANTHOSIS HYPERKERATOSIS HRT1HORPHOSIS FATTY PNEUHOHIA CHRONIC ULCER FOCAL ACANTHOSIS PARAKERATOSIS INFLAHHATION HURINE PNEUMONIA CHRONIC HURINE INFLAHHATION CHRONIC INFLAHHATION HETAHORPHOSIS FATTY PNEUMONIA CHRONIC HURINE INFLAHHATION INFLAHHATION INFLAHHATION PNEUMONIA CHRONIC HURINE { ( ( ( c ( ( ( ( ( c ( f f ( r SL 068358 t c ( c 1732. 1733. 1734 . 1735. 1736. 1737. 1738. 1740. 1741. 1742. 1743. 1744. 1745. 1748. 1748. 1749. 1750. 1751. 1752. 1753. 1754. 1755. 1756. 1757. 1758. 1759. 1760. 1761. 1762. 1763. 1764. 1765. 1766. 1767. 1768. 1769. 1770. 1771. 1772. 1773. 1774. 1775. 1776. * 1777. 1778. 1779. 1780. 1781. 1782. 1783. 1784. 1785. 1786. . !^rtPLETE--KOT VERIFIED --11/10/76 APPENDIX B. HISTOPATHOLOGY - RATS INDIVIDUAL HISTOPATHOLOGY OF FEMALE RATSrLOW DOSE NCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C00511 1,2-DICHLOROBTHANE GROUP: 01-074F WEEKS OR STUDY DISP ANIMAL CODE NDMBER TOPOGRAPHY TUMORS MORPHOLOGY OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY 63 NATO 029 100 NATD 030 85 NATD 031 PITBITARY 85 NATD 032 77 NATD 033 MAMMARY GLAND 98 NATD 034 STOMACH MAMMARY GLAND SDBCOT TISSUE 84 NATD 035 PITUITARY THYROID MAMMARY GLAND 85 NATD 036 THYROID 52 NATD 037 92 NATD 038 UTERUS MAMMARY GLAND CHROMOPHOBE ADENOMA FIBROADENOMA SQUAMOUS CELL CARCINOMA FIBROADENOMA HEBA NGIOSARCOHA CHROMOPHOBE ADENOMA FOLLICULAR-CELL ADENOMA FIBROADENOMA FOLLICULAR-CELL ADENOMA ENDOMETRIAL STROMAL POLYP FIBROADENOMA ADRENAL AORTA KIDNEY PANCREAS MESENTERY UTERUS ADRENAL LUNG STOMACH LUNG KIDNEY STOMACH LUNG UTERUS ADRENAL LUNG GASTRIC SUBMUCOSA LUNG ANGIECTASIS MEDIAL CALCIFICATION INFLAMMATION CHRONIC PERIARTERITIS PERIARTERITIS INFLAMMATION ANGIECTASIS PNEUMONIA CHRONIC MURINE ULCER FOCAL PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC ULCER FOCAL PNEUMONIA CHRONIC MURINE HYDROHETRA ANGIECTASIS PNEUMONIA CHRONIC MURINE ULCER PNEUMONIA CHRONIC HORIHE ADRENAL ADRENAL CORTEX LUNG KIDNEY LUNG PERICARDIUM LUNG STOMACH ANGIECTASIS DEGENERATION PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC PNEUMONIA CHRONIC MURINE INFLAMMATION PNEUMONIA CHRONIC MURINE INFLAMMATION SL 68359 ( ( ( c ( ( ( c c ( c r V \f C i ( ( c c ( c 1797. 1788. 1789. 1790. 1791. 1792. 1793. 1795. 1796 . 1797. 1798. 1799. 1800. 1802. 1803. 1804. 1805. 1806. 1807, 1808. 1809. 1810. 1811. 1812 1813. 1814. 1815 1816 1817 1818. 1819. 1820. 1821 1822 1823 1824 1825 1826 1827 1828 1829 1830 1831 "1832 1833 1834 1835 1836 1837 HPLSTE-- WOT VERIFIED--11/10/76 APPENDIX B. HISTOPATHOLOGY - RATS INDIVIDUAL HISTOPATBOLOGY OF FEMALE HATS.LOW DOSE NCI CONTRACT: 723278 HAZLETON SCI CHEMICAL: C00511 1,2-DICHLOROETHANE GROUP: 01-074F WEEKS ON STDDY DISP ANIMAL CODE NUMBER TOPOGRAPHY TOHORS MORPHOLOGY 54 102 NATD 039 NATD 040 PITUITARY HAHNARY GLAND CHROROPHOBE ADSNOHA FIBROADENOHA 109 NATD 041 LIVER HEPATOCELLULAR CARCINOHA 93 NATD 042 UTERUS SPLEEN LARGE INTESTINE 74 NATD 043 EHDOHETBIAL STROHAL POLYP HEHANGIOSARCOBA HER A HGIOSA RCOHA 56 NATD 044 92 NATD 045 88 NATD 046 OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY LUNG LUNG KIDNEY UTERUS LUNG STOHACH STOHACH LUNG ' KIDNEY PNEUMONIA CHRONIC MURINE PNEUMONIA CHRONIC HURIRE INFLAHHATION CHRONIC INFLAMHATIOB PNEUMONIA CHRONIC HURINE ACANTHOSIS HYPERKERATOSIS PNEUHONIA CHRONIC HURINE INFLAHHATION CHRONIC LUNG PERICARDIUM MYOCARDIUM BONE HARROW LUNG ADRENAL ADRENAL CORTEX LUNG STOHACH STOHACH STOHACH LONG KIDNEY STOHACH STOHACH STOHACH PNEUHONIA CHRONIC HURINE INFLAHHATION IHFLAHHATIOS HETAHORPHOSIS FATTT PNEUMONIA CHRONIC HURINE ANGIECTASIS DEGENERATION PNEOHONIA CHRONIC HURINE NICER FOCAL ACANTHOSIS HYPERKERATOSIS PNEOHONIA CHRONIC HOKIKE INFLAHHATION CHRONIC INFLAHHATION ACANTHOSIS HYPERKERATOSIS SL 68360 1638. 1839. 1840. 1841. 1842. 1843. 1848.' 1846. 1847. 1848 . PLETE--NTOT VERIFIED --11/10/76 APPENDIX B. HISTOPATHOLOGY - RATS INDIVIDUAL HISTOPATHOLOGY OF FEMALE RATS.LOW DOSE NCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C00511 1,2-DICHLOROETHANE GROUP: 01-074F 1849. 1850. 1851 . 1853. 1854. 1855. 1856. 1857. 1858. 1859.1 1860. 1861. 1862. 1863. 1864. 1865. 1866 ., 1867.' 1868.f 1869.1 1870.' 1871. 1872. 1873. WEEKS ON STUDY DISP ANIMAL TUMORS CODE NUMBER TOPOGRAPHY MORPHOLOGY 88 NATD 047 SUBCUT TISSUE/AXILLA FIBROMA SOBCUT TISSUE/GROIH FIBROMA MAMMARY GLAND FIBROADENOMA 104 MSAC 048 MAMMARY GLAND FIBROADENOMA no 6> TSAC 049 THYROID MAMMARY GLAND 84 NATD 050 FOLLICULAR-CELL ADENOMA FIBROADENOMA OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY LUNG STOMACH STOMACH VAGINA PNEUMONIA CHRONIC MURINE ACANTHOSIS HYPERKERATOSIS INFLAMMATION LUNG KIDNET STOMACH STOMACH PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC ACANTHOSIS HYPERKERATOSIS LONG UTERUS KIDNEY LIVER PNEUMONIA CHRONIC MURINE INFLAMMATION INFLAMMATION CHRONIC ANGIECTASIS LUNG PNEUMONIA CHRONIC MURINE CERVICAL LYMPH NODE INFLAMMATION STOMACH ULCER FOCAL 1874.' 1875. 1876. 1877. DISPOSITION CODES: ACCK: AUTO: MISS: MSAC: ACCIDENTALLY KILLED AUTOLYSIS HISSING MORIBUND SACRIFICE NATD: NATURAL DEATH SSAC: SCHEDULED SACRIFICE TSAC: TERMINAL SACRIFICE OTHR: OTHER f ( ( c ( c r c c ( V SL 068361 C C ( ( 1878. 1879 . 1880. 188 I . 1882. 1883. 1885 . 1886 . 1887. 1888. 1889. 1890. 1891. 1892. 1899. 1895. ~ 1896. 1897. 1898. 1899. 1900. 1901. 1902. 1903. 1904. 1905. 1906. 1907. 1908. 1909. 1910. 1911. 1912. 1913. 1914. 1915. 1916. 1917. 1918. 1919. 1920 . 1921. 1922. 1923. 1924. 1925. 1926. 1927. SI P L ET E--NOT VERIFIED-- 11/10/76 APPENDIX B. HISTOPATHOLOGY - FATS INDIVIDUAL HISTOPATHOLOGY OF PEMALB BATS.HIGH DOSE NCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C0051T 1,2-DICffLOROETHAHE GROUP: 01-075F HEEKS ON STUDY DISP ANIMAL CODE NUMBER TOPOGRAPHY TUMORS MORPHOLOGY OTHEB PATHOLOGY TOPOGRAPHY MORPHOLOGY 16 NATD 001 48 NATD 002 MAMMARY GLAND ADENOCARCINOMA 76 NATD 003 OVARY GRANULOSA-CBLL TUMOR SUBCUT TISSUE/GROIN FIBROMA 12 NATD 004 84 NATD 005 SUBCUT TISSUE FIBROADENOMA 74 NATD 006 SUBCUT TISSUE/NECK ADENOCARCINOMA 70 NATD 007 PITUITARY CHROMOPHOBE ADENOMA SUBCUT TISSUE/AXILLA FIBROSARCOMA 57 NATD 008 MAMMARY GLAND FIBROADENOMA 80 NATD 009 MAMMARY GLAND ADENOCARCINOMA STOMACH STOMACH ACANTHOSIS HYPERKERATOSIS SPLEEN HEMATOPOIESIS LUNG STOMACH STOMACH PNEUMONIA CHRONIC MURINE ACANTHOSIS HYPERKERATOSIS NO LESION REPORTED LUNG ADRENAL ADRENAL CORTEX PNEUMONIA CHRONIC MURINE ANGIECTASIS DEGENERATION SPLEEN LIVEB/CENTRILOBULAR LIVER LUNG HEMATOPOIESIS NECROSIS INFLAMMATION PNEUMONIA CHRONIC MURINE LUNG STOMACH STOMACH PNEUMONIA CHRONIC MURINE ACANTHOSIS HYPERKERATOSIS LUNG SPLEEN LIVER PNBUHONIA CHRONIC MURINE HEMATOPOIESIS INFLAMMATION LUNG SPLEEN STOMACH STOMACH PNEUMONIA CHRONIC MURINE HEMATOPOIESIS ACANTHOSIS HYPERKERATOSIS S1, 068362 1928. 1929 . 1930. 1931. 1932. 1933. 1934 . 1936. 1937. 1938. 19 39. 1940 .' 1941. 1942. 1944. 1945. 1946. 1947. 1948. 1949. 1950. 1951. 1952. 1953. 1954. 1955. 1956. 1957. 1958. 1959. 1960. 19611962. 1963. 1964. / 1965. ' 1966. 1967. 1968. 1969: 1970. 1971. 1972. 1973. 1974. 1975. 1976. M PL ETE -- HOT VERIFI ED-- 11/10/76 APPENDIX B HISTOPATHOLOGY HATS INDIVIDUAL BISTOPATHOLOGY OF FEMALE RATS.HIGH DOSE SCI CONTRACT: 723278 HAZLETON SCI CHEMICAL: C00511 1,2-DICHLOBOETHANE GROUP: 01-075F SEEKS OS STUDY DISP ANIMAL CODE NUMBER TOPOGRAPHY TUMORS MORPHOLOGY OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY 93 HATD 010 KIDNEY MAMMARY GLA8D 8 NATO Oil 55 HATD 012 MAMMARY GLAND 59 SATD 013 MAMMARY GLAND MAMMARY GLAND 64 NATD 014 72 SATD 015 PITUITARY TUBULAR-CELL ADENOMA FIBROADENOMA ADENOCARCINOMA ADENOCARCINOMA FIBROADENOMA CHROMOPHOBE ADENOMA 53 HATD 016 12 HATD 017 STOMACH STOMACH STOMACH VAGINA OVARY SPLEEN LONG LUNG LUNG SIDNEY VAGINA LUNG SPLEEN KIDNEY BILE DUCT LIVER OVARY LUNG HEART KIDNEY STOMACH INFLAMMATION ACANTHOSIS HYPERKERATOSIS INFLAMMATION CYST HO LESION REPORTED HEMATOPOIESIS PNEUMONIA CHRONIC HURINB PNEUMONIA CHRONIC MURINE PNEUMONIA CHRONIC MDRIHE INFLAMMATION CHRONIC INFLAMMATION PNEUMONIA CHRONIC MURINE HEMORRHAGE INFLAMMATION CHRONIC HYPERPLASIA ANGIECTASIS CYST PNEUMONIA CHRONIC MURINE THROMBUS ORGANIZED INFLAMMATION CHRONIC ULCER FOCAL MULTIPLE TUMOR SL 068363 1977. 197a. 1979. 1980. 1981. 1982. 1988. 1985. 1986. 1987. 1988. 1989. 1990. 1993. 1993. 1994. 1995. 1996. 1997. 1998. 1999. 2000. 2001. 2002. 2003. 2004. 2005. 2006. 2007. 2008. 2009. 2010. 2011. 2012. 2013. 2014. 2015. 2016. 2017. 2018. 2019. .2020 .2021 2022. 2023. 2024. 2025. 2026. 2027. 8PLET E -- \O'" VSFIFIED--11/10/76 APPENDIX B. HISTOPATHOLOGY - RATS INDIVIDUAL HISTOPATHOLOGT OF FEMALE RATS.HIGH DOSE NCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C00511 1,2--DICELOROETHANE GROUP: 01-075F WEEKS ON STDDY DISP ANIMAL CODE NUMBER TOPOGRAPHY TUMORS MORPHOLOGY 87 NATD 018 50 NATD 019 SUBCUT TISSUE PITUITARY 58 NATD 020 MAMMARY GLAND 73 NATD 021 MAMMARY GLAND 56 NATD 022 MAMMARY GLAND PITUITARY 67 NATD 023 KIDNEY MAMMARY GLAND 57 NATD 024 MAMMARY GLAND LUNG 54 MSAC 025 MAMMARY GLAND 6 NATD 026 ADENOCARCINOMA CHROMOPHOBE ADENOMA ADENOCARCINOMA FIBROADENOMA ADENOCARCINOMA CHROMOPHOBE ADENOMA TUBULAR-CELL ADENOCARCINOMA FIBROADENOMA ADENOCARCINOMA ADENOCARCINOMA METASTATIC FIBROADENOMA OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY ADRENAL ADRENAL CORTEX HEART LIVER SPLEEN LUNG UTERUS LUNG SPLEEN LUNG SPLEEN LUNG KIDNEY SPLEEN SPLEEN STOMACH LUNG AORTA LUNG PERICARDIUM MYOCARDIUM SPLEEN LUNG SPLEEN ANGIECTASIS DEGENERATION THROMBUS ORGANIZED INFLAMMATION HEMATOPOIESIS PNEUMONIA CHRONIC MURINE INFLAMMATION PNEUMONIA CHRONIC MURINE HEM ATOPOIESIS PNEUMONIA CHRONIC MURINE HEMATOPOIESIS PNEUMONIA CHRONIC MURINE INFLAMMATION CHRONIC HEMORRHAGE HEMATOPOIESIS ULCER FOCAL PNEUMONIA CHRONIC MURINE THROMBUS ORGANIZED PNEUMONIA CHRONIC MURINE INFLAMMATION INFLAMMATION HEMATOPOIESIS PNEUMONIA CHRONIC MURINE HEMATOPOIESIS NO LESION REPORTED SL 068364 2023 . 2029. 2030. 2031 . 2032 . 2033. 2038. 2036. 2037. 2038. 20 39. 2040. 2041. 2042 . 2044. 2045. 2046. 2047. 2048. 2049. 2050. 2051. 20 5 2. 2053. 2054. 2055. 2056. 2057. 2058. 2059. 2060. 2061. 2062. 2063. 2064. 2065. 2066. 2067. 20 68.. 2069. 2070. 2071. 2072. 2073. 2074. 2075. 2076. 2077. 2078. 2079. OHPLETE--NOT VERIFIED--11/10/76 APPENDIX B. HISTOPATHOLOGY - HATS INDIVIDUAL HISTOPATHOLOGY OF FEMALE HATS.HIGH DOSE NCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C00511 1,2-DICHLOROETHANE GROUP: 01-075F REEKS ON STUDY DISP ANIMAL CODE NUMBER TOPOGRAPHY TUMORS MORPHOLOGY OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY 63 NATD 027 SUBCUT TISSUE/NECK ADENOCARCINOMA LUNG ADENOCARCINOMA METASTATIC KIDNEY LIPOMA SUBCUT TISSUE/BACK HEHARG10SARCOMA 2 NATD 028 67 NATD 029 UTERUS LIVER ENDOMETRIAL STROMAL POLYP HEMANGIOSARCOMA 48 NATD 030 36 NATD 031 MAMMARY GLAND 54 US AC 032 MAMMARY GLAND ADENOCARCINOMA ADENOCARCINOMA 65 NATD 033 SUBCUT TISSUE/AXILLA FIBROMA SPLEEN HEMANGIOSARCOMA 21 NATD 034 79 NATD 035 PITUITARY CHROMOPHOBE ADENOMA 15 NATD 036 PLEURA LUNG HEART HEART LUNG LONG SPLEEN UTERUS LUNG LUNG ADRENAL LUNG SALIVARY GLAND SALIVARY GLAND KIDNET UTERUS LUNG STOMACH INFLAMMATION PNEUMONIA CHRONIC MURINE THROMBUS ORGANIZED THROMBUS ORGANIZED PNEUMONIA CHRONIC BURINS PNEUMONIA CHRONIC BURINS HEMATOPOIESIS INFLAMMATION PNEUMONIA CHRONIC MURINE PNEUMONIA CRROHIC MURINE ANGIECTASIS PNEUMONIA CHRONIC BURINE ATROPHY FIBROSIS IKFLAHBATION CHRONIC INFLABBATION PNEUMONIA CHRONIC MURINE ULCER FOCAL * MULTIPLE TUMOR ( r C c c r ( C C (. c c ( ( / r ( C C SL 068365 { 2080 2081 2062 2083 2084 2085 2089 2088 2089 2090 2091. 2092. 2093.. 2099. 2096. 2097. 2093. 2099. 2100. 2101. 2102. 2103. 2104. 2105. 2106. 2107. 2108. 2109. 2110. 2111. 2112. 2113. 2114. 2115 2' 2116. 2117. 2118. 2119. 2120. 2121. 2122. 2123. 2124. 2125. 2126. 2127. 2128. 2129. 2130. 2131. 2132 MPLBT 2--SOI' VERIFIED-- 11/10/76 ( APPENDIX B. HISTOPATHOLOGY - RATS INDIVIDUAL HISTOPATHOLOGY OF FEEALE RATS.HIGH DOSE NCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C00511 1,2-DICHLOROETHANE GROUP: 01-075P WEEKS ON STUDY DISP ANIMAL CODE NUMBER TOPOGRAPHY TUMORS MORPHOLOGY OTHER PATHOLOGY TOPOGRAPHY MORPBOLOGY 26 NATO 037 75 NATO 038 ADRENAL CORTICAL CARCINOMA 59 NATO 039 MAMMARY GLAND ADENOCARCINOMA SUBCUT TISSUE/AXILLA FIBROSARCOMA 2 NATO 040 85 NATD 041 MAMMARY GLAND MAMMARY GLAND A DEN OCARCIMO HA FIBROADENOMA 35 MSAC 042 MAMMARY GLAND ADENOCARCINOMA 70 NATO 043 SUBCUT TISSUE HEMANGIOSARCOMA 54 NATD 044 78 NATD 045 KIDNEY PANCREAS 20 NATO 046 MAMMARY GLAND TUBULAR-CELL ADENOMA HEMANGIOSARCOMA ADENOCARCINOMA LUNG PERICARDIUM MYOCARDIUM UTERUS LUNG STOMACH STOMACH ADRENAL ADRENAL CORTEX LUNG LUNG SPLEEN LITER LONG SPLEEN ADRENAL ADRENAL CORTEX SPLEEN LUNG PERICARDIUM LUNG SALIVARY GLAND LITER PNEUMONIA CHRONIC INFLAMMATION INFLAMMATION HYDROHETRA MURINE PNEUMONIA CHRONIC MURINE ACANTHOSIS HYPERKERATOSIS ANGIECTASIS DEGENERATION PNEUMONIA CHRONIC MURINE NO LESION REPORTED PNEUMONIA CHRONIC MURINE HEMATOPOIESIS INFLAMMATION PNEUMONIA CHRONIC MURINE HEMATOPOIESIS ANGIECTASIS DEGENERATION HEM ATOPOIESIS PNEUMONIA CHRONIC MURINE INFLAMMATION PNEUMONIA CHRONIC MURINE INFLAMMATION INFLAMMATION * MULTIPLE TUMOR ( f (' Si 06S366 2133. 21 34. 2135. 2136 * 2137. 2138. 21382141. 2142. 2143. 2144 . 2145. 2146. 2145, 2149. 2150. 2151. 2152. 2153. 2154.' 2155. 2156. 2157.1 2158. 2159. 2160. 2161. 2162. 2163. 2164. 2165. 2166. 2167. 2166. OMPLETE --SOT VERIFIED--11/10/76 APPENDIX B. KISTOPATHOLOGY - BATS INDIVIDUAL RISTOPATHOLOGY OP PEHALE BATS.HIGH DOSE NCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C00511 1,2-DICHLOROETHANE GROUP: 01-075F REEKS ON STUDY DISP ANIMAL CODE NUMBER TOPOGRAPHY TUMORS MORPHOLOGY 54 NATO 047 MAMMARY GLANU ADENOCARCINOMA 54 8 ATD 048 MAMMARY GLAND ADENOCARCINOMA 84 NATO 049 28 NATD 050 OTHER PATHOLOGT TOPOGRAPHY MOR PHOLOGT LUNG STOHACH STOMACH PNEUMONIA CHRONIC MURINE ACANTHOSIS HYPERKERATOSIS LUNG SPLEEN LIVER PNEUMONIA CHRONIC MURINE HEMATOPOIESIS INFLAMMATION LUNG CERVICAL LTHPH NODE KIDNEY SPLEEN PNEUMONIA CHRONIC MURINE INFLAMMATION INFLAMMATION CHRONIC HEMORRHAGE NO LESION REPORTED DISPOSITION CODES: ACCK: AUTO: MISS: HSAC: ACCIDENTALLY KILLED AUTOLYSIS MISSING MORIBUND SACKIPICB NATO: NATURAL DEATH SSAC: SCHEDULED SACRIFICE TSAC: TERMINAL SACRIFICE OTHR: OTHER < f ( f c ( f SL 068367 i 2577. 2578. 2579. 2580. 2581 . 2582. 2583. 2585. 2586. 2587. 2588. 2589. 22559930-. 2593. 2594. 2595. 2596. 2597. 2598. 2599. 2600. 2601. 2602. 2603. 2604. 2605. 2606. 2607. 2608. 2609. 2610. 2611 . 2612. 26 13. 2614. 2615. 2616. 2617. 2618. 2619. 2620. 2621. 2622. 2623. 2624. 2625. 2626. 2627. 2628. HPLETE --NOT VERIFIED--11/10/76 APPENDIX C. HISTOPATHOLOGY - MICE INDIVIDUAL HISTOPATHOLOGY OF HALE ___HICE.CONTROL fUNTRl NCI CONTRACT: 723278 HAZLETON NCI CHEHICAL: C00511 1,2--DICHLOROETHANE GROUP: 02-H087 WEEKS ON STUDY DISP ASIHAL CODE NUMBER TOPOGRAPHY TUHORS MORPHOLOGY OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY (f? 90 & 90 19 90 Q 90 t. 89 87 70 66 60 56 55 49 TSAC 001 TSAC 002 TSAC 003 TSAC 004 ------ TSAC 005 LIVER SKIN OF BACK HEPATOCELLULAR CARCINOHA FIBROSARCOHA TSAC TSAC 006 007 -- ----------------- ------------------------ AUTO 008 HSAC 009 AUTO 010 NATO on NATD 012 NATO 013 AUTO 014 NATD 015 LIVER HEPATOCELLULAR CARCINOHA KIDNEY SUBCUT TISSUE SKIN KIDNEY KIDNEY KIDNEY SPLEEN KIDNEY KIDNEY KIDNEY SPLEEN INFLAMMATION CHRONIC NO LESION REPOSTED NO LESION REPORTED ABSCESS NO LESION REPORTED INFLAMMATION AUTOLYSIS/HO NECROPSY PE NO LESION REPORTED AUTOLYSIS/NO NECROPSY PE INFLAMMATION CHRONIC AMYLOIDOSIS INFLAMMATION CHRONIC AMYLOIDOSIS PYELONEPHRITIS AUTOLYSIS/NECROPSY PERF/ INFLAMMATION CHRONIC AMYLOIDOSIS AMYLOIDOSIS c r r C c c c c c c c c c c (. ( ( c c SL 068368 C 2629. 26 30. 2631. 2632. 2633. 2634. 2636. 2637. 2638. 2639. 2640 . 2641. 2642. 2648. 2645. 2646. 2647. 2648. 2649. 2650. 2651 . 2652. 2653. 2654. 2655. 2656. 2657. 2658. 2659. 2660. 2661. 2662. 2663. IftPLSTE -- NOT VERIFIED--11/10/76 APPENDIX C. H13TOPATHOLOGY - HICE INDIVIDUAL HISTOPATHOLOGY OF HALE HICE.CONTROL fUNTRl SCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C00511 1 ,2-DICBLOROETHANE GROUP: 02-M081 WEEKS ON STUDY DISP ANIHAL CODE NOSBER TOPOGRAPHY TUMORS MORPHOLOGY OTHER PATHOLOGY TOPOGRAPHY HORPHOLOGY 47 NATD 016 46 NATD 017 44 NATD 018 39 NATD 019 25 NATD 020 KIDNEY KIDNEY SPLEEN KIDNEY KIDNEY SPLEEN KIDNEY PYELONEPHRITIS A HY LOIDOSIS AMYLOIDOSIS INFLAMMATION CHRONIC AMYLOIDOSIS AMYLOIDOSIS NO LESION REPORTED PYELONEPHRITIS NO LESION REPORTED DISPOSITION CODES: ACCK: ABTO: MISS: HSAC: ACCIDENTALLY KILLED AOTOLYSIS HISSING MORIBOND SACRIFICE NATD: NATURAL DEATH SSAC: SCHEDULED SACRIFICE TSAC: TERMINAL SACRIFICE OTHR: OTHER SL 068369 2664 . 2665. 2666. 2667. 2668. 2669. 2670. 2672. 2673. 2674. 2675. 2676. 2677. 2678. 26802681 . 2682. 2683. 2684. 2685. 2686. 2687. 2688. 2689. 2690. 269T . 2692. 2693. 2694 . 2695. .2696. 2697 2698. 2699. 2700. 2701. 2702. 2703. 2704. 2705. '2706. 2707. 2708. 2709. 2710. 2711 . 2712. 2713. 27 14. 2715. 2716. 2717. 2718. r r* r bMPLETEr-NOU ,/EHIFJED-- 11/10/7 6 APPENDIX C. HISTOPATHOLOGY - MICE INDIVIDUAL HISTOPATHOLOGY OP BALE MICE.CONTROLfVEff) SCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C00517 1,2-DICHLOROETHANE GROUP; 02-M077 WEEKS ON STUDY DISP ANIMAL CODE NUMBER TOPOGRAPHY TUMORS MORPHOLOGY OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY 90 TSAC 001 90 TSAC 002 90 TSAC 003 MULTIPLE ORGANS 90 TSAC 004 LITER 90 TSAC 005 90 TSAC 006 90 TSAC 007 90 TSAC 008 KIDNEY 90 TSAC 009 70 NATO 010 90 TSAC 011 90 TSAC 012 82 NATD 013 STOMACH RENAL LYMPH NODE MALIG.LYMPHOMA LYMPHOCYTIC TYPE HEPATOCELLULAR CARCINOMA HALIG.LYMPHOMA LTMPHOCYTIC TYPE SQUAMOUS CELL CARCINOMA SQUAMOUS CELL CARCINOMA HETASTAT SKIN OF BACK INFLAMMATION SPLEEN KIDNEY KIDNEY AMYLOIDOSIS INFLAMMATION CHRONIC AMYLOIDOSIS STOMACH STOMACH ACANTHOSIS HYPERKERATOSIS MESENTERIC LTMPHNODE ANGIECTASIS SPLEEN HEMATOPOIESIS PENIS EPIDERMAL INCLUSION CYST KIDNEY INFLAMMATION CHRONIC KIDNEY INFLAMMATION CHRONIC KIDNEY COLON INFLAMMATION CHRONIC BEHATODIASIS KIDNEY INFLAMMATION CHRONIC MESENTERIC LTMPHNODE INFLAMMATION PANCREAS INFLAMMATION COLON NEMATODIASIS BRAIN/HEHIKGES INFLAMMATION KIDNEY INFLAMMATION CHRONIC MESENTERIC LTMPHNODE INFLAMMATION NO LESION REPORTED SPLEEN KIDNEY KIDNEY AMYLOIDOSIS INFLAMMATION CHRONIC AMYLOIDOSIS * MULTIPLE TUMOR c C ( c f c c c c c. c c c ( (' f \ \ c c SL 068370 ( 2719. 2720. 2727. 2722. 2723. 2729. 2726. 2727. 2728. 2729. 2730. 2731. 2732. 27 38. 2735. 2736. 2738. 2739. 2740. 2741. 2742. 2743. 2744. 2745. 2746. 2747. 2748. 2749. 2750i 2752. 2753. 2754. 2755. 2756. 2757. 2758. 2759. 2760. 2761. 2762. 2763. 2764. 2766. 2767. 2768. 2769. 2770. 2771. 2772. ^Bpn ?fBT E tWOT torgR^PI-BD **11/10/7 6 APPENDIX C. HISTOPATHOLOGY - MICE INDITIDUAL HISTOPATHOLOGY OP HALE BICE.CONTROL fTBHI NCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C00511 1,2--DICRLOROETHANE GROUP: 02-H071 WEEKS ON DISP ANIMAL TUMORS OTHER PATHOLOGY STUDY CODE NUMBER TOPOGRAPHY MORPHOLOGY TOPOGRAPHY MORPHOLOGY ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 79 AUTO 019 AUTOLYSIS/NO NECROPSY PE 75 NATD 015 SPLEEN KIDNEY KIDNEY AMYLOIDOSIS INPLAHHATION CHRONIC AMYLOIDOSIS 70 NATD 016 KIDNEY INPLAHHATION CHRONIC ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 73 NATD 017 KIDNEY INFLAHHATION CHRONIC KIDNEY AHYLOIDOSIS SPLEEN AHYLOIDOSIS LITER AHYLOIDOSIS HEART THROMBUS ORGANIZED BNDOCAHDIUH INFLAMMATION SYOCARDXUH INFLAHHATION 72 NATD 018 SPLEEN KIDNEY KIDNEY LITER KIDNEY PROSTATE SUBCOT TISSUE AHYLOIDOSIS INFLAMMATION CHRONIC AHYLOIDOSIS AHYLOIDOSIS PYELONEPHRITIS INPLAHHATION ABSCESS 69 NATD 019 KIDNEY INPLAHHATION CHRONIC KIDNEY AHYLOIDOSIS SPLEEN AHYLOIDOSIS LITER AHYLOIDOSIS MESENTERIC LYHPHHODS ANGIECTASIS 63 NATD 020 SPLEEN COLON AMYLOIDOSIS HEM ATODIASIS DISPOSITION CODES: ACCK: AUTO: MISS: HSAC: ACCIDENTALLY KILLED AOTOLYSIS MISSING MORIBUND SACRIFICE NATD: NATURAL DEATH S SAC: SCHEDULED SACRIFICE TSAC: TERMINAL SACRIFICE OTHR: OTHER SL 068371 f c er c c f ( (; ( ( ( ( ( C ( ( c r t 2773. 277a. 2775. 2776. 2777. 2778. 2780. 2783. 2782. 2783. 2784 . 2785. 2786. 2788. 2789. 2790. 2793 . 2792. 2793. 2794. 2795. 2796. 2797. 2798. 2799. 2800. 2803; 2802. 2803. 2804. 2805. 2806. 2807. 2808. 2809. 2810. 2871. 2812. 2813. 2814. 2815. 2816. 2817. 2818. 2819. 2820. 2821 . 2822. 2823; 2824. 2825. 2826. 2827. *!PLBTE--MOT VERIFIED--11/10/76 APPENDIX C. 81STOPATHOLOGY - DICE INDIVIDUAL HISTOPATHOLOGY OF HALE HICE.LOW DOSE NCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C0051T 1,2-DICHLOROETHANE GROUP: 02-H072 SEEKS ON STUDY DISP ANIHAL CODE NUMBER TOPOGRAPHY TUMORS MORPHOLOGY OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY p 90 TSAC 001 69 NATD 002 68 NATD 003 66 NATO 004 65 NATD 005 58 AUTO 006 54 NATD 007 STOMACH STOMACH ACANTHOSIS HYPERKERATOSIS SPLEEN AMYLOIDOSIS KIDNEY INFLAMMATION CHRONIC KIDNEY AMYLOIDOSIS MESENTERIC LYMPHNODE INFLAMMATION HEART ENDOCARDIUM MYOCARDIUM SPLEEN KIDNEY KIDNEY LITER STOMACH STOMACH THROMBUS ORGANIZED INFLAMMATION INFLAMMATION AMYLOIDOSIS INFLAMMATION CHRONIC AMYLOIDOSIS AMYLOIDOSIS ACANTHOSIS HYPERKERATOSIS KIDNEY KIDNEY SPLEEN INFLAMMATION CHRONIC AMYLOIDOSIS AMYLOIDOSIS HEART KIDNEY KIDNEY KIDNEY SPLEEN LITER CALCIUM DEPOSITION INFLAMMATION CHRONIC AMYLOIDOSIS CALCIUM DEPOSITION AMYLOIDOSIS AMYLOIDOSIS AUTOLYSIS/NO NECROPSY PE HEART ENDOCARDIUM SPLEEN KIDNEY TESTIS TESTIS THROHBUS ORGANIZED INF LA MH ATION AMTLOIBOSIS AHYLOIDOSIS ATROPHY CALCIOM DEPOSITION SL 068372 2883. 2884. 2885. 2886. 2887. 2888. 2888 . 2891. 2892. 2893. 2894. 2895. 2896. 2898. 2899. 2900. 2901. 2902. 2903. 2904. 2905. 2906. 2907. 2908. 2909. 2910. 2911 i 2912. 2913. 2914. 2915. 2916. 2917. 2918. 2919. 2920. 2921. 2922. 2923. 2924. 2925. 2926. 2927. 2928. 2929. 2930. 2931. 2932. 2933. 2934. 2935. 2936. L ii l MPLETE HOT . HE?Xjj|cEp--11/10/76 APPEHDIX C. HISTOPATHOLOGY - MICE INDIVIDUAL HISTOPATHOLOGT OF HALE HICE .LOW DOSE HCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C00511 1,2-DICHLOROETHANE GROOPi 02-H072 WEEKS ON STUDY DISP ANIMAL CODE NUMBER TOPOGRAPHY TUMORS MORPHOLOGY OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY 73 NATD 018 71 62 9 90 78 NATD 019 AUTO 020 TSAC 021 NATD 022 STOMACH SQUAMOUS CELL CARCINOMA 77 NATD 0 23 76 NATD 024 MESENTERIC LYMPHNODE HALIG.LYMPHOMA HISTIOCYTIC TYPE 67 NATD 025 KIDNEY MALIG.LYMPHOMA HISTIOCYTIC TYPE 65 NATD 026 59 NATD 027 KIDNEY ----------------------------------------58 NATD 028 ---------------------------------------- HALIG.LYMPHOMA HISTIOCYTIC TYPE KIDNEY SPLEEN KIDNEY BRAIN/HBNINGES KIDNEY SPLEEN KIDNEY KIDNEY LUNG SPLEEN KIDNEY KIDNEY SUBCUT TISSUE LUNG TRACHEA KIDNEY KIDNEY SPLEEN SPLEEN SPLEEN KIDSET KIDNET SPLEEN KIDNEY KIDNEY AMYLOIDOSIS AMYLOIDOSIS INFLAMMATION CHRONIC INFLAMMATION ADTOLYS IS/NECROPSY PER?/ INFLAMMATION CHRONIC AMYLOIDOSIS INFLAMMATION CHRONIC AMYLOIDOSIS PNEUMONIA CHRONIC MURINE AMYLOIDOSIS INFLAMMATION CHRONIC AMYLOIDOSIS ABSCESS PNEUMONIA CHRONIC MURINE INFLAMMATION PYELONEPHRITIS AMYLOIDOSIS AMYLOIDOSIS AMYLOIDOSIS AMYLOIDOSIS AMYLOIDOSIS INFLAMMATION CHRONIC AMYLOIDOSIS INFLAMMATION CHRONIC AMYLOIDOSIS SL 068374 r 29 37. 2938. 2939. 2940. 2941. 2942. 2943. 2945. 2946. 2947. 2948. 2949. 2950. 2952. 2953. 2954. 2955. 2956. 2957. 2958. 2959. 2960. 2961. 2962. 2963. 2964. 2965. 2966. 2967. 2968 i. 2969. 2970. 2971. 2972. 2973. 2974. 2975. 2976. 2977. 2978. 2979. 2980. 2981. 2982: 2983. 2984. 2985. 2986^' 2987. 2988. 2989. 2990. 2991. 2992. fHPLETE--ir0T VERIFIED--31/10/76 APPENDIX C. HTSTOPATHOLOGY - BICE INDIVIDUAL HISTOPATHOLOGY OF HALE MICE.LON DOSE NCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C00511 1,2-DICHLOROETHANE GROUP: 02-H072 HBEKS ON ST0DY DISP ANIHAL CODE N0BBER TOPOGRAPHY TUMORS HORPHOLOGY OTHER PATHOLOGY TOPOGRAPHY BOR PHOLOGY 44 AUTO -- 33 NATD 029 030 90 TSAC 031 90 TSAC 032 LIFER 6> 90 TSAC 033 &> 90 TSAC 034 SKIN OF BACK MULTIPLE ORGANS & 90 TSAC 035 79 NATD 036 LIVES 77 NATD 037 MULTIPLE ORGANS 64 NATD 038 MULTIPLE ORGANS 61 NATD 039 54 &... 90 NATO 040 TSAC 041 HEPATOCELLULAR CARCINOMA SQUAMOUS CELL CARCINOMA MALIG.LYMPHOMA HISTIOCYTIC TYPE HEPATOCELLULAR CARCINOMA MALIG.LYMPHOMA HISTIOCYTIC TYPE MALIG.LYMPHOMA HISTIOCYTIC TYPE KIDNEY KIDNEY SPLEEN SEMINAL VESICLE KIDNEY STOMACH STOMACH LARGE INTESTINE KIDNEY SOBCHT TISSUE SKIN LARGE INTESTINE TRACHEA KIDNEY STOMACH KIDNEY KIDNEY LUNG SPLEEN KIDNEY SPLEEN ABTOLYSIS/NO NECROPSY PE INFLAHKATIOH CHRONIC AMYLOIDOSIS AMYLOIDOSIS INFLAMMATION INFLAMMATION CHBOBIC ACANTHOSIS HYPERKERATOSIS NEHATODIASIS INFLAMMATION CHRONIC ABSCESS EPIDERMAL INCLUSION CYST NEHATODIASIS INFLAMMATION INFLAMMATION CHRONIC HYPERKERATOSIS INFLAMMATION CHRONIC AMYLOIDOSIS -------------------------------PNEUMONIA CHRONIC MURINE AMYLOIDOSIS AMYLOIDOSIS ------------ AMYLOIDOSIS --------------- NO LESION REPORTED ---------------- MULTIPLE TCMOS t ' C c G G C C? - 7? #: c. c & SL 068375 C 2993. 2994 . 2995. 2996. 2997. 2998. 2099. 3001. 3002. 3003. 3004. 3005. 3006. 3008. 3009. 3010. 3011 . 3012. 3013. 3014. 3015. 3016. 3017. 3018. 3019. 3020. 3021. 3022. 3023. 3024. 3025. 3026. 3027. 3028. 3029. 3030. 3031. 3032. 3033. 3034. 3035. 3036. 3037. 3038. 3039. 3040. MPLETE HOT VERIFIED--; 11/10/76 APPENDIX' C- HISTOPATHOLOGT - MICE INDIVIDUAL HISTOPATHOLOGT OF HALE MICE.LOW DOSE NCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C00511 1,2-DICHLOROETHANE GROOP: 02-H072 WEEKS ON STUDY DISP ANIHAL CODE NUMBER TOPOGRAPHY TUMORS MORPHOLOGY OTHER PATHOLOGY TOPOGRAPHY HOR PHOLOGY 86 NATD 042 63 NATD 043 LIVER LUNG 80 NATD 044 MULTIPLE ORGANS 79 NATD 045 73 NATO 046 71 NATD 047 LIVER LUNG 59 AUTO 048 57 NATD 049 17 NATD 050 HEPATOCELLULAR CARCINOMA ALVEOIAS/BBONCHIOLAR ADENOMA HALIG.LYMPHOMA HISTIOCYTIC TYPE HEPATOCELLULAR CARCINOMA HEPATOCELLULAR CARCINOMA METASTA KIDNEY LARGE INTESTINE KIDNEY KIDNEY SPLEEN KIDNEY KIDNEY SPLEEN SUBCOT TISSUE KIDNEY SPLEEN NO LESION REPORTED PYELONEPHRITIS NEM ATODIASIS INFLAMMATION CHRONIC AMYLOIDOSIS AMYLOIDOSIS INFLAMMATION CHRONIC AMYLOIDOSIS AMYLOIDOSIS ABSCESS AOTOLYSIS/NO NECROPSY PE INFLAMMATION CHRONIC AMYLOIDOSIS NO LESION REPORTED * MULTIPLE TDHOR DISPOSITION CODES: ACCK; A0TO: HISS: MSAC: ACCIDENTALLY KILLED ADTOLYSIS HISSING MORIBUND SACRIFICE NATD: NATURAL DEATH SSAC: SCHEDULED SACRIFICE TSAC: TERHINAL SACRIFICE OTHR: OTHER SL 068376 c c c c c ( c c c c c c C c c c c 30 4 T. 3042. 3043. 30 44. 3045. 3046. 3048. 3049. 3050. 3051. 3052. 3053. 3054. 3056. 3057. 3058. 3059. 3060. 306T. 3062. 3063. 3064. 3065. 3066. 3067. 3068. 3069. 3070. 3071 . 3072. 3073. 3074. 3075. 3076. 3077. 3078. 3079. 3080. 3081 k 3082. 3083; 3084. 3085. 3086. 3087. 3088. 3089. 3090. 3091. 3092. 3093. 3094. <> : PLETE NOT'"VP El PI ED^ p/10/7 6 APPENDIX C. HISTOPATHOLOGY - HICE INDIVIDUAL HISTOPATHOLOGY OP BALE HICE.HIGH DOSE NCI CONTRACT: 723278 HAZLETON NCI CHEHICAL: C00511 1,2--DICHLOHOETHANE GROUP: 02-H073 WEEKS ON STUDY DISP ANIHAL CODE NUMBER TOPOGRAPHY TUMORS MORPHOLOGY & 90 TSAC 001 90 TSAC 002 LIVER LUNG HEPATOCELLULAR CARCINOHA ALTEOLAR/BRONCHIOLAR ADENOMA 90 6> TSAC 003 MULTIPLE ORGANS & 90 TSAC 004 LUNG $ 90 84 82 63 59 24 TSAC 005 AUTO 006 AUTO 007 NATO 008 MULTIPLE ORGANS NATD 009 NATD 010 <P 90 TSAC Oil LIVER HALIG.LTHPEOHA HISTIOCYTIC TYPE ALTEOLAR/BRONCHIOLAR ADENOMA HALIG.LYMPHOMA HISTIOCYTIC TYPE HEPATOCELLULAR CARCINOMA 90 TSAC 012 LIVER HEPATOCELLULAR CARCINOHA OTHER PATHOLOGY TOPOGRAPHY BOR PHOLOGY KIDNEY SPLEEN SPLEEN STOMACH STOMACH LARGE INTESTINE STOHACH STOMACH LARGE INTESTINE LIVER LARGE INTESTINE KIDNEY INFLAMMATION CHRONIC AMYLOIDOSIS HEMATOPOIESIS ACANTHOSIS HYPERKERATOSIS NEHATODIASIS ACANTHOSIS HYPERKERATOSIS NEHATODIASIS HYPERPLASIA NODULAR NEHATODIASIS INFLAMMATION CHRONIC AUTOLYSIS/HO NECROPSY PE AUTOLYSIS/NO NECROPSY PE LUNG PNEUMONIA CHRONIC MURINE SPLEEN URINARY BLADDER HEMATOPOIESIS INFLAMMATION STOHACH STOMACH ACANTHOSIS HYPERKERATOSIS MESENTERIC LYHPHNODE ANGIECTASIS SKIN ACANTHOSIS SKIN ACARIASIS * HOLTIPLE TUMOR SL 068377 3095. 3096. 3097. 3098. 3099 . 3100. 3101. 3103. 3104. 3105. 3106. 3107. 3108. 3109. 3111. 3112. 3113. 3114. 3115. 3116. 3117. 3118. 3119. 3120. 3121. 3122. 3123. 3124. 3125. 3126. 3127. 3128. 3129. 3130. 3131. 3132. 3133. 3134. 3135. 3136. 3137. 3138. 3139. 3140. 3141. 3142. 3143. 3144. 3145. 3146. 3147. ft PLETE--HOT VERIFIED^-11/10/76 ei - - APPENDIX C. HISTOPATHOLOGT - BICE INDIVIDUAL HISTOPATHOLOGT OF BALE' BICE,HIGH DOSE BCI CONTRACT: 723278 HAZLETON NCI CHEBICAL: C00511 1,2-DICHLOROETHANE GROUP: 02-H073 REEKS ON STODT DISP ANIHAL CODE NUHBER TOPOGRAPHY TUMORS BORPHOLOGY OTHER PATHOLOGY TOPOGRAPHY BORPHOLOGY CP 91 91 88 65 58 23 12 12 (9 91 <9 91 r) 91 Q 91 TSAC 013 LUNG KESENTERIC ALVEOLAH/BRONCHIOLAR ADENOBA TSAC 014 LIVER LUNG MULTIPLE ORGANS HEPATOCELLULAR CARCINOBA HEPATOCELLULAR CARCINOMA HETASTA MALT.LYMPHOMA HISTIOCYTIC TYPE SATD 015 LUNG ALVEOLAR/BBOHCHIOLAR ADENOBA SUBCUT TISSUE/AXILLA FIBROSARCOHA NATD 016 SUBCUT TISSUE/BACK FIBROSAHCOMA NATD 017 NATD 018 NATD 019 NATD 020 TSAC 021 LIVER TSAC 022 TSAC 023 TSAC 024 STOMACH LIVER LUNG HEPATOCELLULAR CARCINOMA SQUAMOUS CELL CARCINOMA HEPATOCELLULAR CARCINOMA ALVEOLAH/BRONCHIOLAR ADENOMA MESENTERIC LYHPHNODE ANGIECTASIS SPLEEN HEMATOPOIESIS KIDNEY KIDNEY LITER LUNG EPIDIDYMIS SPLEEN INFLAMMATION CHRONIC AMYLOIDOSIS AMYLOIDOSIS PNEUMONIA CHRONIC MURINE SPERHATOGENIC GRANULOMA AMYLOIDOSIS EPIDIDYMIS SPERHATOGENIC GRANULOMA NO LESION REPORTED HO LESION REPORTED NO LESION REPORTED LUNG TESTIS PNEUMONIA CHRONIC MURINE ATROPHY KIDNEY INFLAMMATION CHRONIC LUNG PNEUMONIA CHRONIC MURINE KIDNEY INFLAMMATION CHRONIC * MULTIPLE TUMOR SL 068378 e e C c c c c c c c ( r (. (' C c c c. c 3148. 3149. 3150. 3151. 3152. 3153. 3158 . 3156. 3157. 3156. 3159. 3160. 3161. 316S. 3164. 3165. 3166. 3167. 3168. 3169. 3170. 3171. 3172. 3173. 3174. 3175. 3176. 3177. 3178. 3179. 3180. 3181. 3182. 3183. 3184. 3185. 3186. 3187. 3188; 3189. 3190. 3191. 3192. 3193. 3194. 3195. 3196. 3-197. 3198. 3199. 3200. 3201. ri ' PLETE- NOT '.VERIFIED 11/10/76 APPENDIX C. HISTOPATHOLOGY - HICE INDIVIDUAL HISTOPATHOLOGY OF HALE BICE.HIGH DOSE SCI COSTRACT: 723278 HAZLETON NCI CHEMICAL: C005T1 1,2-DICHLOROETHANE GROUP: 02-M073 WEEKS ON STUDY DISP ANIMAL CODE NUMBER TOPOGRAPHY TUMORS MORPHOLOGY OTHER PATHOLOGY TOPOGRAPHY HORPHOLOGY 86 SATD 025 KIDNEY LUNG TESTIS INFLAMMATION CHRONIC PNEUMONIA CHRONIC MURINE ATROPHY 81 NATD 026 LUNG STOMACH STOMACH PNEUMONIA CHRONIC MURINE ACANTHOSIS HYPERKERATOSIS 78 NATD 027 NO LESION REPOSTED 76 NATO 028 STOMACH LITTER SQUAMOUS CELL CARCINOMA HEPATOCELLULAR CARCINOMA KIDNEY KIDNEY SPLEEN LUNG TESTIS URINARY BLADDER INFLAME ATION CHRONIC AMYLOIDOSIS AMYLOIDOSIS PNEUMONIA CHRONIC MURINE ATROPHY CALCIUM DEPOSITION 75 NATD 029 SPLEEN PERICARDIUM KIDNEY KIDNEY LUNG STOMACH AMYLOIDOSIS INFLAMMATION INFLAMMATION CHRONIC AMYLOIDOSIS PNEHHONIA CHRONIC MURINE HYPERKERATOSIS 73 NATD 030 LIVES HEPATOCELLULAR CARCINOMA SPLEEN KIDNEY KIDNEY AMYLOIDOSIS INFLAMMATION CHRONIC AMYLOIDOSIS 88 NATD 031 LUNG ALVEOLAR/BSOHCHIOLAR ADENOMA SUBCUT TISSUE/BACK FIBROSARCOMA KIDNEY INFLAMMATION CHRONIC 86 NATD 032 LUNG ALVEOLAR/BRONCHIOLAR ADENOMA KIDNEY INFLA! ATION CHRONIC KIDNEY AMYLOIDOSIS SPLEEN AMYLOIDOSIS TESTIS CALCIUM DEPOSITION ------------- -- ---- --- ------ ------- ------------- ---- -- ----------------------- --- --- -- --- -------- ----------- PROSTATE --------------- ----------- INFLAMMATION ------>---------- - ------------------T'------------ ----- t r e c c c c c r C C t c c c c c c c 068379 i; 3202. 3203. 3204. 3205. 3206 . 3207. 3208. 3210. 3211. 3212. 3213. 3214. 3215. 3218. 3218. 3219. 3220. 3221 . 3222. 3223. 3224. 3225. 3226. 3227. 3228. 3229. 3230. 3231. 3232. 3233. 3234. 3235. 3236. 3237. 3238. 3239. 3240. 3241. 3242. 3243. 3244. 3245. 3246. 3247. 3248. 3249. 3250. 3251. 3252. 3253- 3254. * PLETE--NOT VERIFIER--11/10/76 APPENDIX C. HISTOPATHOLOGT - MICE INDIVIDUAL HISTOPATHOLOGY OF HALE SCI CONTBACT: 723278 HAZLETON 8ICE.HIGH DOSE NCI CHEMICAL: C00511 1,2-DICHL0H0ETHANE GROUP: 02-E073 WEEKS ON STUDY DISP ANIHAL CODE NUHBER TOPOGRAPHY TUHORS MORPHOLOGY OTHER PATHOLOGY TOPOGRAPHY HOR PHOLOGY 81 NATD 033 LIVER LUNG 78 NATD 034 66 NATD 035 65 NATD 036 LIVER 61 NATD 037 MULTIPLE ORGANS 56 AUTO 038 37 NATD 039 12 NATD 040 ) 91 TSAC 041 LUNG HEPATOCELLULAR CARCINOMA ALVEOLAE/BRONCH10LAR ADENOHA HEPATOCELLULAR CARCINOHA MALIG.LYMPHOMA HISTIOCYTIC TYPE SPLEEN KIDNEY KIDNEY KIDNEY HEART HEART STOMACH SPLEEN KIDNEY KIDNEY LUNG SPLEEN KIDNEY KIDNEY LONG SPLEEN KIDNEY URINARY BLADDER KIDNEY KIDNEY HEART URINARY BLADDER ALVEOLAR/BRONCHIOLAR ADENOHA AMYLOIDOSIS INFLAMMATION CHRONIC CALCIUM DEPOSITION AMYLOIDOSIS THROMBUS ORGANIZED CALCIUM DEPOSITION CALCIUM DEPOSITION AMYLOIDOSIS INFLAMMATION CHRONIC AMYLOIDOSIS PNEUMONIA CHRONIC MURINE AMYLOIDOSIS INFLAMMATION CHRONIC AMYLOIDOSIS PNEUMONIA CHRONIC MURINE AMYLOIDOSIS INFLAMMATION CHRONIC CALCULUS INFLAMMATION CHRONIC AMYLOIDOSIS CALCIUM DEPOSITION CALCIUM DEPOSITION AUTOLYSIS/NECROPSY PERF/ HO LESION REPORTED NO LESION REPORTED * MULTIPLE TUMOR SL 068380 < ( c ( c c c (' ( ( c: c c c c. c c <; 32 55 . 3256. 3257. 3258. 3259. 3260. 3263. 3263. 3264. 3265. 3266 3267 3263 3239 3271. 3272. 3273. 3274. 3275. 3276. 3277. 3278. 3279. 3280. 3281. 3282. 3283. 3284. 3285. 3286. 3287. 3288. 3289. 3290 3291 3292 3293 3294 3295. 3296. 3297. 3298. mPLETE--sqr .VERIFIED--11/70/76 ' sJ 'i i: APPENDIX C. HISTOPATHOLOGY - BICE \ INDIVIDUAL HISTOPATHOLOGY OF KALB NICE.HIGH DOSE NCI CONTRACT: 723278 HAZLETON NCI CHEBICAL: C00511 7,2-DICHLOBOETHANE GSOUP: 02-B073 WEEKS ON STUDY DISP ANIHAL CODE NUMBER TOPOGRAPHY TUMORS MORPHOLOGY <9 97 97 0 97 % 97 0 91 ) 91 (v 91 17 TSAC 042 TSAC 043 TSAC 044 TSAC 045 TSAC 046 TSAC 047 TSAC 048 NATD 049 LUNG ALVEOLAR/BRONCHIOLAR ADENOMA SPLEEN HEMANGIOSARCOMA MESENTERIC LYMPHNODE HEMANGIOSARCOMA LUNG SUBCUT TISSUE/BACK ALYROLAR/BRONCSIOLAR ADENOMA FIBROSARCOMA LUNG ALVEOLAR/BRONCHIOLAR ADENOMA LUNG ALVEOLAR/BRONCHIOLAR ADENOMA LIVER LUNG HEPATOCELLULAR CARCINOMA ALVEOLAR/BRONCHIOLAR ADENOMA LITER HEPATOCELLULAR CARCINOMA LUNG ALVEOLAR/BRONCHIOLAR ADENOMA 12 NATD 050 OTHER PATHOLOGY TOPOGRAPHY BOR PHOLOGY SPLEEN AMYLOIDOSIS TESTIS TESTIS LUNG URINARY BLADDER LARGE INTESTINE ATROPHY CALCIUM DEPOSITION PNEUMONIA CHRONIC MURINE INFLAMMATION NEH ATODIASIS NO LESION REPORTED DISPOSITION CODES: ACCK: ACCIDENTALLY KILLED AUTO: AUTOLYSIS BISS: KISSING KSAC: MORIBUND SACRIFICE NATD: NATURAL DEATH SSAC: SCHEDULED SACRIFICE TSAC: TERMINAL SACRIFICE OTHR: OTHER SL 068381 3627. 3626. 3629. 3630 . 3631. 3632. 3639 . 3635. 3636. 3637. 3638. 3639. 3640. 3643. 3643. 3644. 3645. 36 46. 3647. 3648. 3649. 3650. 3651. 3652. 3653. 3654. 3655. 3656. 3657. 3658. 3659. 3660. 3561. 3662. 3663. 3664. 3665. 3666. 3667. 3668. 3669. 3670. 3671. 3672. 3673. 3674. 3675. 3676. 3677. 3678. 3679. 3680. 3681. itlPLETE--NOT VERIFIED-Wl/10/76 -. - u, u. ji L ti t ii 3 APPENDIX D. ffIS TO PATHOLOGY - MICE INDIVIDUAL HISTOPATHOLOGY OF FEMALE MICE.CONTROLfUNTRl NCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C00511 1,2--DICHLOBOETHANE GROUP: 02-F081 SEEKS ON STODY DISP ANIMAL CODE NUMBER TOPOGRAPHY TUMORS MORPHOLOGY OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY / 90 TSAC 001 90 TSAC 002 90 f 90 90 f> 90 90 TSAC 003 MULTIPLE ORGANS TSAC 004 LONG TSAC 005 TSAC 006 TSAC 007 79 77 22 91 91 91 f NATO 008 NATD 009 AUTO 010 TSAC Oil TSAC 012 MULTIPLE ORGANS TSAC 013 91 TSAC 014 91 lv TSAC 015 MULTIPLE ORGANS BALIG.LYMPHOMA LYMPHOCYTIC TYPE ALVEOLAR/BRONCHIOLAR ADENOMA PANCREAS UTERUS/BNDOHBTRIBH OVARY UTERUS OVARY UTERUS OVARY OVARY s 0TEROS/EN DOMETRIUH HALIG.LYMPHOMA LYMPHOCYTIC TYPE, ? UTEROS/ENDOMETRIUM 0TERUS/ENDOMETRYOH OVARY DTEROS/ENDOHETRIOH OVARY MALIG.LYMPHOMA HISTIOCYTIC TYPE UTEROS/ENDOHBTRIUH OVARY INFLAMMATION INFLAMMATION INFLAMMATION HYDROHETRA CYST HO LESION REPORTED NO LESION REPORTED HYDROHETRA CYST CYST NO LESION REPORTED ADTOLYSIS/NO NECROPSY PE HYPERPLASIA CYSTIC HYPERPLASIA CYSTIC HYPERPLASIA CYSTIC CYST HYPERPLASIA CYSTIC CYST HYPERPLASIA CYSTIC CYST * MULTIPLE TUMOR c c c c c r ( C c c c C: t c c e c ( ( SL 068382 c C 3682. 3683. 36eu. 3685. 3686. 3687. 3689. 3690. 3691. 3692. 3693. 3694. 3695. 3693. 3698. 3699. 3700. 3701. 3702. 3703. 3704. 3705. 3706. 3707. 3708. 3709. 3710. 3711. 3712. 3713. 3714. 3715. 3716. fMPLETE--NOT jVERIEBBD-^- 11/10/76 APPENDIX D. HISTOPATHOLOGY - MICE INDIVIDUAL HISTOPATHOLOGY OP FEMALE BICE-CONTROLfmtTffl NCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C00511 1,2--DICHLOSOETHANE GROUP: 02-F081 WEEKS ON DISP STUDY CODE _____ ,___________________ ANIMAL NUMBER TOPOGRAPHY TDMOHS 91 TSAC 016 MORPHOLOGY 91 TSAC 017 91 TSAC 018 \ir 90 TSAC 019 85 HATD 020 OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY UTEBUS/ENDOH ETRIUH OVARY OVARY UTERUS UTBBUS/EN DOMETRIUH OVART UTERUS/ENDOMETRIUB OVARY OVARY HYPERPLASIA CYSTIC CYST INFLAMMATION HYDROMRTRA HYPERPLASIA CYSTIC CYST INFLAMMATION CYST CYST DISPOSITION CODES: ACCK: ACCIDENTALLY KILLED AUTO: AUTOLYSIS BISS: MISSING fiSAC: nORIBOHD SACRIFICE HATDr NATURAL DEATH SSAC: SCHEDULED SACRIFICE TSAC: TERMINAL SACRIFICE OTHR: OTHER SL 068383 c 3717. 3718. 3719 . 37 203721. 3722. 3723. 3725. 3726. 3727. 3728. 3729. 3730. 3733. 3733. 3734. 3735. 37 36. 3737. 3738. 3739. 3740. 3741. 3742. 3743. 3744. 3745. 3746. 3747. 3748. 3749. 3750. 3751. 3752. 3753. 3754. 3755. 3756. 3757. 3758. 3759. 3760. 3761. 3762. 3763. 3764. 37653766. 3767. 3768. 3769. 3770. 3771. MPLETE--NOT VSRIFIED-^It/10/76 APPENDIX D. HISTOPATHOLOGY - tllCE INDIVIDUAL HISTOPATHOLOGY OF FEMALE HXCB.COHTROT. fVBHI NCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C00511 1,2-DICHLOROBTHANB GROUP: 02-F071 WEEKS ON STUDY DISP ANIMAL CODE NUMBER TOPOGRAPHY TUMORS HORPHOLOGT OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY / 90 V 90 90 J 90 90 90 V 3 90 90 <i 1 90 56 90 1 90 i t v 90 TSAC TSAC 001 ---- 002 OVARY UTEROS/ENDOHETRIUH DTERUS/ENDOHETRIUH OVARY TSAC 003 LUNG ALVEOLAR/BRONCEIOLAR ADENOMA UTBRUS/ENDOHBTRIUM SPLEEN OVARY TSAC 004 OVARY UTEEUS/BBDOHETRIUM TSAC 005 OVART UTEROS/ENDOHETRIUM TSAC 006 UTEROS/EN DOHETRIUM OVARY TSAC 007 UTEROS/ENDOHETRIUM OVARY TSAC 008 STOMACH SQUAMOUS CELL CARCINOMA OVARY UTEROS/ENDOHETRIUM NATD 009 UTERUS NATO 010 MULTIPLE ORGANS HALIG.LYMPHOMA LYMPHOCYTIC TYPE TSAC Oil UTERUS/ENDOHETRIUM OVARY TSAC 012 UTERUS/ENDOHETRIUH OVARY TSAC 013 UTERUS INFLAMMATION HYPERPLASIA CYSTIC INFLAMMATION INFLAMMATION HYPERPLASIA CYSTIC HEMATOPOIESIS INFLAMMATION CYST HYPERPLASIA CYSTIC CYST HYPERPLASIA CYSTIC HYPERPLASIA CYSTIC CYST HYPERPLASIA CYSTIC CYST CYST HYPERPLASIA CYSTIC HYDROMETRA HYPERPLASIA CYSTIC CYST HYPERPLASIA CYSTIC CYST HYDROMETRA * MULTIPLE TUMOR SL 068384 r f c c c c ( c c c \r c c. c C C C c; c. r 3772 3773 3774 3775 3776 3777 3778 3780 3781 3782 3783 3784 3785 378B 3788 3789 3790 3791 3792 3793 3794 3795 3796 3797 3798 3799 3800 3801 3802 3803 3804 3805 3806 3807 3808 3809 3810. 3811. 3812. 3813.' 3814. PLETS--NOT VERIFIED- *T T/TO/76 i i_ -- -- Lti "ui APPENDIX D. HISTOPATHOLOGY - MICE INDIVIDUAL HISTOPATHOLOGY OF FEMALE MICE.CONTROL fVBHI NCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C00511 1,2-DICHLOROETHANE GROUP: 02-P077 REEKS OS DISP ANIMAL TUMORS STODY CODE NUMBER TOPOGRAPHY MORPHOLOGY OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY 90 TSAC 014 LIVER MULTIPLE ORGANS 90 / 90 t7 TSAC 015 TSAC 016 MULTIPLE ORGANS 11/ 90 A 90 TSAC 017 MULTIPLE ORGANS TSAC 018 65 NATD 019 60 NATD 020 HEPATOCELLULAR CARCINOMA HALIG.LYHPHOHA HISTIOCYTIC TYPE HALIG.LYMPHOMA HISTIOCYTIC TYPE HALIG.LYHPHOHA LYMPHOCYTIC TYPE URINARY BLADDER OVARY UTEROS/ENDOMETSIUM UTERUS/EN DOHBTBI0H STOMACH STOMACH OVARY UTERUS/EHDOHETRIBM INFLAMMATION CYST HYPERPLASIA CYSTIC INFLAMMATION ACANTHOSIS HYPERKERATOSIS CYST HYPERPLASIA CYSTIC UTERUS OVARY COLON UTERUS HTDROHETRA CYST NEHATODIASIS NO LESION REPORTED HYDROBETHA * MULTIPLE TUMOR DISPOSITION CODES: ACCK: AUTO: MISS: MSAC: ACCIDENTALLY KILLED ADTOLYSIS HISSING MORIBUND SACRIFICE UATD: NATURAL DEATH SSAC: SCHEDULED SACRIFICE TSAC: TERMINAL SACRIFICE OTHR: OTHER SL 068385 ( ( ( c c ( c c c ( ( l r c ( c ( c { V.. c 3015. 3816. 3817 . 381s3819. 3820. 3822. 3823. 3824. 3825. 3826. 3827. 3828. 3830. 3831. 3832. 3833. 3834. 3835. 3836. 3837. 3838. 3839. 3840. 3841. 3842. 3843. 3844. 3845. 3846. 3847. 3848. 3849. 3850. 3851. 3852. 3853. 3854. 3855. 3856. 3857. 3858. 3859. 3860.3861 . 3862. 3863. 3864.3865. 3866. 3867. 3868. 3869." " 1 - i:--- /* *PLETE--NOT VERIFIED--T1/10/76 APPENDIX D. HISTOPATHOLOGY - NICE INDIVIDUAL HISTOPATHOLOGY OF FEMALE BICE.LOW DOSE NCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: CQ0511 1 , 2-DICHLOROETHANE GROUP: 02-P074 WEEKS ON STUDY DISP ANIHAL CODE NUMBER TOPOGRAPHY TUMORS MORPHOLOGY OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY { 91 TSAC 001 UTERUS LUNG MULTIPLE ORGANS 91 TSAC 002 5 91 91 < 91 TSAC 003 TSAC 004 TSAC 005 LONG 91 TSAC 006 *1 91 4 91 87 TSAC 007 TSAC 008 NATO 009 UTERUS COLON 81 1 91 NATD 010 TSAC 011 UTERUS ADENOCARCINOMA ALVEOLAR/BHONCHIOLAR ADENOMA HALIfl.LYMPHOMA HISTIOCYTIC TTPE ALVEOLAR/BHONCHIOLAR ADENOHA ADENOCARCINOMA ADENOCARCINOMA ENDOMETRIAL STROMAL SARCOMA OVARY INFLAMARTIOM UTERUS OVARY UTERUS UTERUS/EHDOHETRIUH STOMACH STOMACH OTERUS/ENDOHETRIUM OTA BY STOMACH OVARY PERITONEUM UTERUS SPLEEN UTERUS/ENDOSETRIHB INFLAMMATION CYST INFLAMMATION HYPERPLASIA CYSTIC ACANTHOSIS HYPERKERATOSIS HYPERPLASIA CYSTIC CYST HYPERKERATOSIS INFLAMMATION INFLAMMATION INFLAMMATION HEMATOPOIESIS HYPERPLASIA CYSTIC LIVER SPLEEN KIDNEY LUNG LIVER SPLEEN OVARY UTERUS INFLAMMATION AMYLOIDOSIS AMYLOIDOSIS PNEUMONIA CHRONIC HUHINE AMYLOIDOSIS HEMATOPOIESIS INFLAMMATION INFLAMSATION * MULTIPLE TUMOR SL 068386 3870 . 3871 . 3872. 3873. 3874. 3875. 3878. 3878. 38793880. 3881. 3882. 3883. 3885. 3886. 3887. 3888. 3889. 3890. 3891. 3B92. 3893. 3894. 3895. 3896. 3897. 3898. 3899. 3900. 3901. 3902. 3903. 3904. 3905. 39063907. 3908. 3909. 3910. 3911. 3912. 3913. 3914. 3915. 3916. 3917. 3918. 3919. 3920.. 3921. 3922- i PLETS--SOT VBBIFI Ep-- 11/10/76 L APPEHDIX D. HISTOPATHOLOGY - MICE INDIVIDUAL HISTOPATHOLOGY OF FEMALE MICE.LOS DOSE SCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C00511 1,2-DICHLOROBTBANE GROUP: 02-F074 . WEEKS OR STUDY DISP ANIMAL CODE NUMBER TOPOGRAPHY TUMORS MORPHOLOGY OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY r 91 91 TSAC 012 MULTIPLE ORGANS TSfiC 013 MULTIPLE ORGANS t V 91 0 91 TSAC 014 TSAC 015 SUBCUT TISSUE/LEG LUNG UTERUS 88 MSAC 016 MAMMARY GLAND 88 NATD 017 MAMMARY GLAND LUHG 82 NATD 018 73 NATD 019 66 NATD 020 91 TSAC 021 MAMMARY GLAND UTERUS MALIG.LYMPHOMA HISTIOCYTIC TYPE HALIG.LYMPHOMA HISTIOCYTIC TYPE OSTEOSARCOMA OSTEOSARCOMA METASTATIC ENDOMETRIAL STROMAL POLYP ADENOCARCINOMA ADENOCARCINOMA ADENOCARCINOMA METASTATIC ADENOCARCINOMA ENDOMETRIAL STROMAL POLYP UTEROS/ENDOHETRIUM OVARY LITER UTERBS/ENDON BTRIBH UYPERPLASIA CYSTIC CYST ANGIECTASIS HYPERPLASIA CYSTIC OVARY UTEROS/ENDOHETRIUM CYST HYPERPLASIA CYSTIC SPLEEN HEMATOPOIESIS MESENTERIC LYMPHNODE INFLAMMATION CERVICAL LYMPH NODE INFLAMMATION KIDNEY PYELONEPHRITIS UTEROS/ENDOHETRIUM HYPERPLASIA OVARY INFLAMMATION SPLEEN OVARY UTERDS/ENDOHETBI0M LARGE INTESTINE AMYLOIDOSIS CYST HYPERPLASIA CYSTIC NEHATODIASXS NO LESION REPORTED SPLEEN UTERUS HEMATOPOIESIS INFLAMMATION UTERUS SKIN SPLEEN INFLAMMATION EPIDERMAL INCLUSION CYST HEMATOPOIESIS UTERUS/ENDOHETRI0M HYPERPLASIA CYSTIC * MULTIPLE TUMOR ( ( ( c ( c c ( c c ( c c c c ( c SL 68387 C 1 3923. 3929. 3925. 3926. 3927. 3928. 3939. 393 3. 3932. 3933. 3934. 3935. 3936. 3939. 3940. 3941. 3942. 3943. 3944. 3945. 3947. 3948. 3949. 3950. 3952. 3954. 3956. 3957. 3958. 3959. 3961. 3963. 3965. 3966. 3967. 3968. 3970. 3971. 3972. 3973. 3974. 3976. PLETE--SOT VERIFIED ,13/10/76 APPENDIX D. HISTOPATHOLOGY - MICE INDIVIDUAL HISTOPATHOLOGY OF FEMALE MICE.LOW DOSE NCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C00511 1,2-DICHLOROETHANE GROUP: 02-F074 WEEKS ON STUDY DISP ANIMAL CODE NUMBER TOPOGRAPHY TUMORS MORPHOLOGY OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY ~ '~ r 91 TSAC 022 MAMMARY GLAND ADENOCARCINOMA OVARY CIST LUNG ADENOCARCINOMA METASTATIC OTEROS HYDROHETRA LARGE INTESTINE NEHATODIASIS ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 91 TSAC 023 MAMMARY GLAND t* UTERUS ADENOCARCINOMA ENDOMETRIAL STROMAL POLYP OVARY CYST 91 TSAC 024 I< ("* 91 TSAC 025 UTERUS/BNDOHETRIOM SKIN OF EYELID SEBACEOUS GLAND SWEAT GLAND UTERUS/ENDOMETRIUM HYPERPLASIA CYSTIC INFLAMMATION INFLAMMATION INFLAMMATION HYPERPLASIA CYSTIC 91 TSAC 026 UTERUS HYDROHETRA 88 NATD 027 SUBCUT TISSUE/GROIN SQUAMOUS CELL CARCINOMA OVARY CYST OVARY GRANULOSA-CELL TUMOR ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 86 NATD 028 ^MULTIPLE ORGANS MALIG.LYMPHOMA HISTIOCYTIC TYPE UTERUS INFLAMMATION 78 NATD 029 SPLEEN MALIG.LYMPHOMA HISTIOCYTIC TYPE UTERUS HYDROHETRA 61 NATD 030 NO LESION REPORTED 91 t-" TSAC 031 UTERUS MAMMARY GLAND ADENOCARCINOMA ADENOCARCINOMA OVARY SKIN SKIN SKIN INFLAMMATION ACANTHOSIS HYPERKERATOSIS ACARIASIS , 91 TSAC 032 MAMMARY GLAND ADENOCARCINOMA OVARY CYST RENAL LYMPH NODE MALIG.LYMPHOMA HISTIOCYTIC TYPE ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- vv 91 TSAC 033 MAMMARY GLAND ADENOCARCINOMA UTERUS/ENDOMETRIUM HYPERPLASIA CYSTIC LARGE INTESTINE NEHATODIASIS * MULTIPLE TUMOR SL 068388 r c c c c ( ( Q ^ f ( ( C ( C c e. 3977. 39 78. 3979. 3980. 3981. 3982. 3988. 3985. 3986. 3987. 3988. 3989. 3990. 399a. 3993. 3994 . 3995. 3996. 3997.' 3998. 3999. 4000. 4001. 4002. 4003. 4004. 4005. 4006. 4007. 4008. 40094010. 4011. 4012. 4013. 4014. 4015. 4016. 4017. 4018. 4019. 40204021. 4022. 4023. 4024. 4025. 4026. 4027. 4028. 4029. 4030. PPLKTE--HGT VERIFIED--11/10/76 APPENDIX D. HISTOEATHOLOGY - MICE INDIVIDUAL RIST0PATHOLOGY OF FBHALE HICE.LOH DOSE NCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C00511 1,2-DICHLOROETRANE GROOP: 02-F074 SEEKS ON ST0DY DISP ANIHAL CODE NUKBES TOPOGRAPHY TOHORS MORPHOLOGY 91 <4 91 TSAC 034 LUNG MULTIPLE ORGANS TSAC 035 HULTIPLE ORGANS ALVEOLAR/BRONCHIOLAR ADENOHA HALIG.LYHPHOMA HISTIOCYTIC TYPE HALIG.LYHPHOHA HISTIOCYTIC TYPE 91 TSAC 036 SPLEEN HEHANGIOSARCOHA 91 n/V TSAC 037 LUNG ALYBOLAR/BRONCHIOLAR ADENOHA A 91 TSAC 038 HARDERIAN GLAND a 91 -l> 46 91 TSAC 039 HOLTIPLE ORGANS HATD 040 TSAC 041 ADENOHA,NOS HALIG.LYHPHOHA HISTIOCYTIC TYPE 91 TSAC 042 91 TSAC 043 ^ 91 TSAC 044 O 91 TSAC 045 LONG LONG ALVEOLAR/BRONCKIOLAR ADENOHA ALVEOLAR/BRONCHIOLAR ADENOHA OTHER PATHOLOGY TOPOGRAPHY HORPROLOGY OVARY DTEBHS/ENDOHETRIOH OVARY OTEROS OTERDS/EKDOHETRIOH OVARY OTEBOS/BNDOHETRIOH OVARY LARGE INTESTINE OVARY OTEROS OVARY DTER0S/ENDOHETRIOH OTEROS OVARY OVARY OTEHOS OVARY OTEROS LARGE ISTESTIWE OVARY OVARY OTEROS/ENDOHETRIOH CYST HYPERPLASIA CYSTIC CYST HYDROHETRA HYPERPLASIA CYSTIC CYST HYPERPLASIA CYSTIC CTST NEHATODIASIS INFLAHHATION INPLAHHATION CYST HYPERPLASIA CYSTIC NO LESION REPORTED IHFLAHHATION INPLAHHATION CYST HYD ROHETRA INPLAHHATION INPLAHHATION NEHATODIASIS IRFLAHHATION CYST HYPERPLASIA CYSTIC * HOLTIPLE TOHOS SL 068389 ( c f c c c c c c c c c c c c c c c c c c c 11031 . 4032. 4033. 4034 . 4035. 4036. 4038. 4039. 4040. 4041. 4042. 4043. 4044. 4046. 4047. 4048. 4049. 405T. 4052. 4054. 4055. 4056. 4057. 4058. 4059. 4060. 4061. 4063. 4064. 4065. 4066. 4067. 4069. 4070. 4071. 4072. 4073. 4074 . 4075. PLETE -- HOT `VERIFIED--11/10/76 APPENDIX D. HISTOPATHOLOGY - MICE INDIVIDUAL HISTOPATHOLOGY OF FEMALE SICE.LON DOSE NCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: COOS 11 1,2-DICELOROETKAKE GROUP: 02-F074 NEEKS ON DISP ANIMAL TUMORS OTHER PATHOLOGY STUDY CODE NUMBER TOPOGRAPHY MORPHOLOGY TOPOGRAPHY HORPHOLOGT ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------- 91 TSAC 046 y LUNG ALVEOLAR/BRONCHIOLAR ADENOMA OVARY INFLAMMATION OTERBS/ENDOHETRIUM HYPERPLASIA CYSTIC i 91 > 86 82 NATD 047 NATD 048 MAMMARY GLAND LUNG STOMACH ADENOCARCINOMA ADENOCARCINOMA METASTATIC SQUAMOUS CELL CARCINOMA SALIVARY GLAND OVARY KIDNEY NATD 049 PANCREAS SQUAMOUS CELL CARCINOMA METASTAT MESENTERIC LYMPHNODE SQUAMOUS CELL CARCINOMA METASTAT SMALL INTESTINE SQUAMOUS CELL CARCINOMA METASTAT LARGE INTESTINE SQUAMOUS CELL CARCINOMA METASTAT SPLEEN SQUAMOUS CELL CARCINOMA METASTAT SUBCUT TISSUE/GROIN ADENOMA,NOS UTERUS ENDOMETRIAL STROMAL SARCOMA STOMACH SQUAMOUS CELL CARCINOMA SHALL INTESTINE SQUAMOUS CELL CARCINOMA METASTAT LARGE INTESTINE SQUAMOUS CELL CARCINOMA METASTAT MESENTERIC LYMPHNODE SQUAMOUS CELL CARCINOMA METASTAT ESOPHAGUS SQUAMOUS CELL CARCINOMA METASTAT CYST CYST PYELONEPHRITIS 70 NATD 050 ^MULTIPLE ORGANS MALIG.LYMPHOMA HISTIOCYTIC TYPE ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- * MULTIPLE TUMOR DISPOSITION CODES: ACCK: AUTO: MISS: MSAC: ACCIDENTALLY KILLED AUTOLISIS MISSING MORIBUND SACRIFICE NATD: NATURAL DEATH SSAC: SCHEDULED SACRIFICE TSAC: TERMINAL SACRIFICE OTHR: OTHER r r c r c ( ( ^ C ( ^ c C C f SL 068390 K. { C 4076. 4077 . 4078. 4079. 4080. 4081. 4082. 4084. 4085. 4086. 4087. 4088. 4089. 4090. 4092. 4093. 4094. 4095. 4096. 4097. 4098. 4099. 4100. 4101. 4102. 4103. 4104. 4105. 4106. 4107. 4108. 4109. 4110. 4111. 4112. 4113. 4114. 4115. 4116. 4117. 4118. 4119. 4120. 4121. 4122. 4123. 4124. 4125. 4126. 4127. 4128 . 4129. POETS -- NOT VERIFIED--11/10/76 1 APPENDIX D. HISTOPATHOLOGY - MICE INDIVIDUAL HISTOPATHOLOGT OF FEMALE HICE.HIGH DOSE NCI CONTRACT: 723278 HAZLETON NCI CHEfllCAL : COOS 11 1,2--DICHLOROETHANE GRODP: 02-F075 MEEKS OH STUDY DISP ANIMAL CODE NUMBER TOPOGRAPHY TUMORS MORPHOLOGY OTHER PATHOIOGr TOPOGRAPHY HORPHOLOGY 75 NATD 001 STOMACH LONG OTERUS LARGE INTESTINE URINARY BLADDER 75 NATD 002 MAMMARY GLAND LUNG 74 NATD 003 LUNG 68 NATD 004 67 NATD 005 65 NATD 006 MAMMARY GLAND LUNG 65 NATD 007 LUNG 62 NATD 008 KIDNEY LUNG 61 A0TO 009 44 NATD 010 SOBCUT TISSUE I) 91 TSAC Oil LUNG 73 NATD 012 STOHACH LONG 73 NATD 013 SQUAMOUS CELL CARCINOMA ALVEOLAR/BRONCHIOLAR ADENOMA ENDOMETRIAL STROMAL SARCOMA ENDOMETRIAL STROMAL SARCOMA META ENDOMETRIAL STROMAL SARCOMA META ADENOCARCINOMA ADENOCARCINOMA METASTATIC ALVEOLAR/BRONCHIOLAR ADENOMA ADENOCARCINOMA ALVEOLAR/BRONCHIOLAR ADEHOHA ALVEOLAR/BRONCHIOLAR ADENOMA TUBULAR-CELL ADENOCARCINOMA ALVEOLAR/BRONCHIOLAR ADENOMA UTERUS UTERHS LUNG UTERUS UTERUS UTERUS OVARY SKIN SQUAMOUS CELL CARCINOMA ALVEOLAR/BRONCHIOLAR ADENOMA SQUAMOUS CELL CARCINOMA ALVEOLAR/BRONCHIOLAR ADENOMA UTERUS LUNG INF LAHM ATION INFLAMMATION PNEUMONIA CHRONIC MURINE INFLAMMATION INFLAMMATION INFLAMMATION CYST EPIDERMAL INCLUSION CYST AUTOLYSIS/NO NECROPSY PE HTDBOMETRA PNEUMONIA CHRONIC HUSINE r r e c c ( C ( ( c ( (- ( i c l t t' c c t 068391 4130. 4131. 4132. 4133. 4134. 4135. 4138. 4138. 4139. 4140. 4141. 4142. 4143. 4146. 4147. 4148. 4149. 4151. 4152. 4153. 4154. 4155. 4156. 4157. 4158. 4159. 4160. 4162. 4T63. 4164. 4166. 4167. 4169. 4171. 4172. 4173. 4174. 4175. 4176. 4178. 4180. 4182. 4184. r~ . , I PLJ5T E--NOT .VERIPI ED--r 1.1/10/76 L APPENDIX D. HISTOPATHOLOGY - 8ICE V f INDIVIDUAL HISTOPATHOLOGY OF FEHALE BICE.HIGH DOSE NCI CONTRACT: 723278 HAZLETON NCI CHEftlCAL: C00511 1,2-DICHLOROETHANE GHOOP: 02-F075 { VEERS ON STUDI DISP ANIMAL CODE NUMBER TOPOGRAPHY TUMORS MORPHOLOGY OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY ( 73 NATD 014 NO LESION REPORTED ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ 70 NATD 015 OTEROS INFLAMMATION ( (_ 68 NATD 016 LONG PHEOHONIA CHRONIC MURINE URINARY BLADDER CALCIOH DEPOSITION f ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ 65 NATD 017 OTEROS ADENOCARCINOMA LUNG THROHBUS ORGANIZED OVARY ADENOCARCINOMA METASTATIC LUNG CALCIOH DEPOSITION( SPLEEN ADENOCARCINOMA METASTATIC PANCREAS ADENOCARCINOMA METASTATIC ( 63 NATD 018 LONG ALVEOLAS/BRONCHIOLAR ADENOMA OVARY GRANULOSA-CELL TOHOR 12 NATD 019 NO LESION REPORTED ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ 11 NATD 020 NO LESION REPOSTED 77 NATD 021 MAMMARY GLAND OTEROS ADENOCARCINOMA ENDOMETRIAL STROMAL POLYP ( 73 NATD 022 LUNG ALVEOLAR/BHONCHIOL1R ADENOMA OVARY CYST 71 NATD 023 OTEROS OVARY ADRENAL KIDNEY PANCREAS SPLEEN ENDOMETRIAL STROMAL SARCOMA ~ ENDOMETRIAL STROMAL SARCOMA META ENDOMETRIAL STROMAL SARCOMA META ENDOMETRIAL STROMAL SARCOMA META ENDOMETRIAL STROMAL SARCOMA META ENDOMETRIAL STROMAL SARCOMA META LONG PNEOHONIA CHRONIC HBRIHE ( ( 70 NATD 024 LONG ALVEOLAR/BRONCHIOLAR ADENOMA 69 NATD 025 LONG ALVEOLAR/BRONCHIOLAR ADENOMA 66 NATD 026 +MABHARY GLAND ADENOCARCINOMA STOMACH CALCIOHDEPOSITION Q * MULTIPLE TUMOR ( SL 068392 ( ( mas. 4186 . 4167. 4iee. 4109. 4190. 4192. 4190. 4194. 4195. 4196 . 4197. 4198. 4299. 4201. 4202. 4203. 4204. 4205. 4206. 4207. 4208. 4209. 4210. 4211. 4212. 42131 4214. 4215. 4216. 4217. 4218. 4219. 4220. 4221. 4222. 4223. 4224. 4225. 4226. 4227. 4228. 4229. 4230. 4231. 4232. 4233. 4234. 4235. 4236. 4237. PLETE--HOT VERIFIED--11/10/76 U APPENDIX D. HISTOPATHOLOGT - MICE INDIVIDUAL HISTOPATHOLOGT OF FEMALE MICE.HIGH DOSE NCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C00511 1,2-DICHLOROETHANE GROUP: 02-F075 WEEKS ON DISP ANIMAL TUMORS STUDY CODS NUMBER TOPOGRAPHY MORPHOLOGY OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY 57 NATO 027 UTERUS 31 NATD 028 12 HATD 029 11 NATD 030 80 NATD 031 UTERUS LIVER LUNG 75 NATD 032 MAMMARY GLAND LUNG 74 NATD 033 STOMACH SPLEEN 68 NATD 034 MULTIPLE ORGANS 63 NATD 035 MAMMARY GLAND LUNG UTERUS 44 AUTO 036 36 NATD 037 STOMACH 12 NATD 038 12 NATD 039 11 NATD 040 ADENOCARCINOMA ADENOCARCINOMA HEPATOCELLULAR CARCINOMA ALVEOLAR/BHONCHIOLAH ADENOMA ADENOCARCINOMA ALVEOLAR/BRONCHIOLAR ADENOMA SQUAMOUS CELL CARCINOMA HALIG.LYMPHOMA HISTIOCYTIC TYPE MALIG.LYMPHOMA HISTIOCYTIC TYPE ADENOCARCINOMA ALVEOLAR/BRONCHIOLAR ADENOMA ENDOMETRIAL STROMAL POLYP BRAIN/HENINGES TRACHEA LIVER OVARY SKIN OP BACK OVARY SQUAMOUS CELL CARCINOMA NO LESION REPORTED HO LESION REPORTED NO LESION REPORTED INFLAMMATION INFLAMMATION THROMBUS ORGANIZED INFLAMMATION EPIDERMAL INCLUSION CYST CYST AUTOLYSIS/NO NECROPSY PE NO LESION REPORTED NO LESION REPORTED HO LESION REPORTED ( c t 'E 0 r c c C c 0 C G G t c r * MULTIPLE TUMOR "c SL 068393 t ' c 4 238 . 4239. 4240. 4241 . 4242. 4243. 4249. 4246. 4247. 4248. 4249. 4250. 4251. 4253. 4254. 4255. 4256. 4257. 4258. 4259. 4260. 4261. 4262. 4263. 4264. 4265. 4266. 4267. 4268. 4269. 4270. 4271. 4272. 4273. 4274. 4275. 4276. 4277. 4278. 4279. 4280. 4281. 4282. #: SPLETE-- SOT YER'IF:TED'VO,r/10/76 APPENDIX D. HISTOPATHOLOGY - MICE INDIVIDUAL HISTOPATHOLOGY OF FEMALE HICE.HTGIT DOSE NCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C00511 1,2-DICHLOROETHANE GROUP: 02-F075 WEEKS ON STUDY DISP ANIMAL CODE NUMBER TOPOGRAPHY TUMORS MORPHOLOGY OTHER PATHOLOGY TOPOGRAPHY MORPHOLOGY 79 NATD 041 LUNG UTERUS LARGE INTESTINE 77 NATD 042 UTERUS 76 NATD 043 MAMMARY GLAND VAGINA 70 NATD 044 STOMACH 69 NATD 045 68 NATD 046 67 NATD 047 LUNG 65 NATD 048 62 NATD 049 14 NATD 050 ALVEOLAE/BRONCHIOLAR CARCINOMA ENDOMETRIAL STROMAL SARCOMA ENDOMETRIAL STROMAL SARCOMA META ADENOCARCINOMA ADENOCARCINOMA ADENOCARCINOMA METASTATIC SQUAMOUS CELL CARCINOMA ALYEOLAR/BRONCHIOLAR ADENOMA KIDNEY OVARY SKIN UTRRUS UTERUS UTERUS OYARY LUNG LUNG HYDRONEPHROSIS CYST ACARIASIS INFLAMMATION INFLAMMATION INFLAMMATION CYST PNEUMONIA CHRONIC MURINE PNEUMONIA CHRONIC MURINE NO LESION REPORTED DISPOSITION CODES: ACCK: A0TO: MISS: HSAC: ACCIDENTALLY KILLED ADTOLYSIS HISSING MORIBUND SACRIFICE NATD: NATURAL DEATH SSAC: SCHEDULED SACRIFICE TSAC: TERMINAL SACRIFICE OTHR: OTHER l r c c c C ( c c c c c t ( 0 ( C. ( SL 068394 ( (. c. NOV 10, 1976 NCT CARCINOGENESIS BIOASSAY EXPERIMENTAL DESIGN STATUS REPORT CONTRACT NUMBER: AGENT ROBBER: LINK NOBBEH: 723278 C00511 010 NABE: HAZLETON LABS NABE: 1,2-DICHLOROETHANE DISPOSITION* COL-GROOP ROLE fPREP RH * IBDBB ) PREPARATION* CHEH CONCENTRATION [AGE AT NOBB PPB {PER CENT)(FIRST (DOSE J ,, " " 7-'. \ h~i -7-. ` - = '! ' Cli. TREATMENT* - AST CNIT RTE FREQ DORA DAIS , `11/ fbirth (6 START [DATES SEX: SPECIES: STOCK/STRAIN: SOPPLIER: BALE RAT OSBORNE BBI BENDEL DATA STATOS* GROOP NOB NOB NON NOB SIZE SOR IADR TBA AOTO REC* V NOB HISTO PERF LATEST OBSERV DATE 2 01-072a TEST 350 (AO 8 C00511 | C00577 [808 C00511 1 C00577 I B08 C00511 1 COO577 50000 950000 75000 930000 75000 930000 ( ( ( ( ( C 5.0) ( 95.0) | 7.5) | 93.0)[ 7-5H 93.0)( 66 122 192 01-073B 350 TEST (AOS C00511 1 COO577 I BOS C00517 E COO577 (BOS COOS11 1 COO577 50000 950000 75000 930000 75000 930000 { ( ( ( ( ( 5-0) [ 95.0) ( 7.5) | 93.0)( 7-5) | 93.0)( 66 122 192 01-071a VEHI [A01 CO0577 1000000 ( 100.0)[ 66 350 1 | A01 COO577 1000000 ( 100.0)[ 122 [A01 COO577 1000000 C 100.0) | 192 01-031B ONTR 1 374 E 50.0 B/K 75.0 B/K 50.0 B/K P04 5D/W P04 5D/H P04 5 D/S 56(JAM 24,72 | BAR 30,72 70 ( 1 420( I 50 100.0 B/K 150.0 B/K 100.0 B/K P04 5D/W P04 5D/B P04 5D/S 56(JAN 24,72 [BAR 30,72 70 ( r 420( t 50 100.0 B/K '' 150.0 B/K 100.0 B/K P04 5D/W P04 5D/S P04 5 D/S 56[JAN [BAR 70 [ 420 [ 24,72 30,72 20 [BAY 31,72 20 [BAY 31,72 1 50 20 0 50 20 4 20 4 0 20 6 0 0 0 0 50 HAY 9,74 3 50 BAR 14,74 3 20 HAY 9,74 3 20 AOG 20,74 3 CHEMICALS C00511 1,2-DICHLOROETHANE CO0577 CORN OIL ABBREVIATIONS P04 - ORAL DOSE (GAVAGE,ETC) B/K - HILLIGRAH/KILOGR AH 5D/S - 5 CONSECOTIVE DAYS/SEEK COHBENTS 1) AGE AT FIRST DOSE OR DOSE CHANGE STATED IN DATS 2} DATE TAKEN FROH LATEST _ CAGE/GROOP OBSERVATION RECORD 3) ALL IADRS HAVE BEEN SOBHITTEB FOR THIS GROOP COL-GROOP 01-072H TEST 01-073B TEST TPHOR PATHOLOGY TOPOGRAPHY HORPHGLOGY NOB HOB SEEKS TOPOGRAPHY HIST TBA TO 1ST PERF TOHOR MORPHOLOGY NOB SEEKS TBA TO 1ST TOHOR SPLEEN NOS STOHACH NOS T0NICA VAGINALIS STOHACH NOS SOBCOT TISSOE/BACK HEHANGIOSAHCOHA HEHANGIOSARCOHA HBSOTHELIOBA NOS SQBAHOOS CELL CARCINOHA FIBROHA NOS 50 6 73.7 THYROID FOLLICBL A H--CELL ADENOHA 3 73.4 HAHBARY GLAND ADENOCARCINOMA NOS 3 68.9 SOBCOT TISSOE/GROIK FIBROHA NOS 2 76.9 PANCREATIC ISLETS ISLET-CELL ADENOHA 2 87.0 ABDOMINAL CAVITY HEHANGIOSARCOHA 2 92.3 2 92.4 2 75.0 1 76.9 1 92.7 STOHACH NOS SQOAHOOS CELL CARCINOHA 50 9 50.7 PANCREAS HEHANGIOSAHCOHA PITOITARY CHROHOPHOBE ADEKOHA (T9 1 4 36.9 SOBCOT TISSUE/GROIN FIBROHA NOS HOLTIPLE ORGANS NOS HEHANGIOSARCOHA 3 61.3 SOBCOT TISSOE/BACK FIBROHA NOS 2 2 2 SL 068395 75.9 67.7 84.3 r C C C c c ( c c e c c. c C C ( ( c ( ( 01-071(1 VEHI 01-031(1 UNTR H NOS T TISSUE 9 EM Ail GI OS AB CO(I A FIBROMA 80S PITUITARY PANCREATIC ISLETS MAMMARY GLAND CHHOMOPROBE ADENOMA ISLET-CELL ADENOMA ADENOCARCINOMA HOS (T9 1 PITUITARY ADRENAL MAMMARY GLAND THYROID SMALL IMTBSTIHE NOS CHROMOPHOBE ADENOMA (T91 CORTICAL CARCINOMA FIBROADENOMA NOS FOLLICULAR-CELL CARCINOMA FIBROSARCOMA NOS f. INCC/iC l: N> UI .0 KIDNEY NOS .9 ADRENAL LIPOMA NOS HEMANGIOSARCOMA HETASTAT 107.6 110.0 110.0 96.6 96.6 96.6 96.6 115.7 MULTIPLE ORGANS NOS SALIVARY GLAND NOS MAMMARY GLAND SUBCUT TISSUE LEUKEMIA LYMPHOCYTIC CARCINOMA,NOS ADENOCARCINOMA NOS FIBROSARCOMA NOS 77.6 77.7 C `C 1 87.0 1 98.7 1 98.7 1 59.7 "( ' " c c "c .c c c c SL 068396 -c c ( -c -^ ( 01-07 IF VBHI 01-031F tJHTH SJ^UT TISSU E/AXIL LA FIBROSARCOMA NOS sBt tissoe/heck ADENOCARCINOMA NOS 2 mte.7 SOBCOT tissoe/groin FIBROMA NOS 2 ^.6 SOBCOT TISS0E ADENOCARCINOMA NOS PITOITART CHROMOPHOBE ADENOMA (T9 1 20 7 90.4 SOBCOT TISSOE/BACK FIBROMA BOS 1 110.0 OYARY BOS GRAHOLOSA-CELL TOMOR 1 110.0 PITOITART MAMMARY GLAKD THYROID MAHMARY GLAND THYROID CHROMOPHOBE ADENOMA (T91 20 6 115.7 KIDNEY NOS ADENOCARCINOMA NOS 2 115.7 PANCREATIC ISLETS C-CBLL CARCINOMA 2 115.7 OTARY NOS FIBROADENOMA NOS 2 66.9 KIDNEY NOS C-CELL ADENOMA 2 66.9 HEART NOS HAMARTOMA ISLET-CELL ADENOMA CYSTA DBNOCARCINOHA MIXED TOMOR MALIGNANT MIXED TOMOR METASTAT 75.6 50.0 C -........ - ' t 2 115.7 1 115.7 1 115.7 1 88.9 1 88-9 t c c c c c c c e c c c c c c ( c. SL 068398 (. c. CONTRACT RUBBER: AGEHT ROBBER: LINK RUBBER: 723278 C00511 030 NAME: RABE: HAZLETON LABS 1,2-DICHLOROETHANE HOV 10, 1976 *ITAL DESIGN STATUS REPORT iHtc . SEX: SPECIES: STOCK/STRAIN: SUPPLIER: HALE HOUSE B6C3F1 CHARLES RIVER 3 DISPOSITION* COL-GROUP ROLE[PREP RB * [RUBB I PREPARATION* CHEH COHCBNTR ATIOR ) AGE AT RUHB PPH (PER CERT) f FIRST DOSE 1 TREATMENT* ABT UNIT RTE FREQ DURA DATS |BIRTH [6 START |DATES GROUP SIZE DATA STATUS* RUH ROH RUH RUH SUR IADR TBA AUTO REC* V 02-B072 TEST 586 (08A C00511 10000 | COO577 990000 i 08A C00511 10000 t COO577 990000 J 08B C00511 15000 1 COO577 - 985000 ( ( ( [ ( ( 1.0) ( 99.0)| 1-0) l 99.0) ( 1.5) ( 98.5) | 35 98 120 75.0 H/K P04 5D/H 100.0 H/K P04 5D/W 100.0 H/K P04 5D/H 631BAX 31,72 |JUL 5,72 22 | 1 t4611 50 0 50 15 4 RUH HISTO PERF 46 LATEST OBSERV DATE 2 APR 3,74 3 02-H073 TEST 586 [08C C00511 1 C00577 |08D C00511 1 COO577 | 08E COOS11 J COO577 20000 980000 40000 960000 30000 970000 {[ ( ( ( { 2.0) ( |98.0)J 4.0) (96.0) f 3.0) 97.0) | 35 98 120 (02-H071 VEHI |Q1A COO577 1000000 100.0) J 586 1 ([01A C00577 1000000 100.0)t 35 98 102-H081 URTR (586 ________ _ 0 150.0 H/K P04 5D/N 200.0 H/K P04 5D/N 200.0 H/K P04 5 D/if 63fHAT 31,72 [JUL 5,72 22) [ 461| t 50 150.0 H/K -- 200.0 H/K P04 5D/H P04 5D/R 63)BAY 31,72 (JUL 5,72 483) )JUN 15,72 )JUR 15,72 20 20 0 50 0 20 0 20 28 4 2 3 1 3 47 APR 3,74 3 19 APR 3,74 3 17 APR 18,74 3 _______ CHEMICALS 000511 1,2-DICHLOROETHANE C00577 CORK OIL ABBREVIATIONS P04 - ORAL DOSE [SAVAGE,ETC) H/K - HILLIGRAH/KILOGHAH 5D/W - 5 CONSECUTIVE DATS/WEEK COMMENTS 1) AGE AT FIRST DOSE OR DOSE CHARGE STATED IK DATS 2) DATE TAKER FROH LATEST CAGE/GRODP OBSERVATION RECORD 3) ALL IADRS HAVE BEER SOBHITTBD FOR THIS GROUP c -( c: c rV c c c c: < c c ( ( COL-GROUP 02-HO72 TEST 02-H073 TEST TUHOR PATHOLOGY TOPOGRAPHY HORPHOLOGY RUH NUB WEEKS TOPOGRAPHY HIST TBA TO 1ST PERF TUHOR HORPHOLOGY NUH NEEKS TBA TO 1ST TUHOR LIVER HOS HBLTIPLB ORGANS NOS KIDHBY ROS HESEHTERIC LYHPHNODE STOHACH NOS HEPATOCELLULAR CARCINOHA KALIG-LYHPHOHA HISTIOCYTI HALIG.LYHPHOHA HISTIOCYTI HALIG.LYHPHOHA HISTIOCTTr SQUAHOOS CELL CARCINOHA 46 6 71.6 SKIN OF BACK 4 63.9 LUNG ROS 2 65.0 LUNG ROS 2 76.3 1 90.3 SQUAHOUS CELL CASCINOBA 1 90.3 ALVEOLAR/BROHCHIOLA R ADEH 1 83.0 HEPATOCELLULAR CARCIBOHA 1 71.6 LUNG NOS LIVER HOS H0LTIPLE ORGANS ROS SUBCUT TISSUE/BACK ALVEOLAR/BRONCHrOLAR ADEN HEPATOCELLULAR CARCINOHA HALIG.LYHPHOHA HISTIOCYTI FIBROSARCOHA ROS 47 15 12 4 3 81.4 SUBCUT TISSUE/1XILLA FIBROSARCOHA ROS 58.3 HESENTERIC LYHPHKODB HALIG.LYHPHOHA HISTIOCYTI 61.4 LUNG HOS HEPATOCELLULAR CARCINOHA 65.0 SPLEEN ROS HEHANGIOSAKCOHA 1 87.9 1 90.7 1 90.7 1 90.7 Si O68399 c c c c 02-M071 VEHI 02-H081 UNTB ACH NOS MULTIPLE ORGANS NOS LIVER NOS KIDNEY NOS STOMACH NOS RENAL LYMPH NODE LIVES NOS SKIN OF BACK SQUAMOUS CELL CARCINOMA MALIG.LYMPHOMA LYMPHOCYTI HEPATOCELLULAR CARCINOMA MALIG.LYMPHOMA LYMPHOCYTI SQUAMOUS CELL CARCINOMA SQUAMOUS CELL CARCINOMA M HEPATOCELLULAR CARCINOMA FIBROSARCOMA NOS 19 17 -6 MESENTERIC LYHPHNODE HEMANGIOSARCOMA 90.0 90.0 90.0 81.7 81.7 61.0 95.0 90.7 SL 068400 MOV 10, 1976 NCI CARCINOGENESIS BIOASSAY EXPERIMENTAL DESIGN STATUS REPORT CONTRACT NUMBER: AGENT NUMBER: LINK HUMBER: 723278 C00511 040 NAME: NAME: HAZLETON LABS 1,2-DICHLOROETHANE r-; - DISPOSITION* COL-GROUP ROLE JPREP RM t |NUMB 1 PREPARATION* CHEM CONCENTRATION | AGE AT NUMB PPM (PER CENT)| FIRST DOSE Jt - TREATMENT* AMT UNIT RTE FREQ DURA DAYS |BIRTH fO STAR (DATES 02-F074 TEST 586 | 08A COOS11 i C00577 (OSD C00511 t C00577 108B C00511 1 C00577 10000 990000 40000 960000 15000 985000 ( ( ( ( { f 1-0J | 99.OJ | 4 .0) | 96,0)I 1-5) | 98.5) 1 35 98 120 125.0 M/K 200.0 H/K 150.0 M/K P04 5D/N P04 5D/H P04 5D/W 63(MAY 31 | JUL 5 22 ( | 461| ( 02-F075 586 TEST |08C I I OSD [ I 08E 1 C00511 COO577 C00511 COO577 C00511 COO577 20000 980000 40000 960000 30000 970000 ( ( ( c { t 2.0) f 98.0) | 4.0) [ 96.0)( 3.0) ( 97.0)r 35 98 120 250.0 M/K 400.0 H/K 300.0 M/K P04 5D/N P04 5 D/S P04 5D/S 63( MAY 31 | JUL 5 221 t 461 ( 1 02-F071 VEBI roiA COO577 1000000 ( 100.0)( 586 i | OlA COO577 1000000 ( 100.0) 1 [Oil CO0577 1000000 t 100.0)1 35 98 120 250.0 M/K 400.0 M/K 300.0 M/K P04 5D/S P04 5D/S P04 5D/S 63(MAY (JUL 22 ( 461 f 31 5 02-F081 UNTR t 586 E 0 (JON 15 | JUN 15 SEX: SPECIES: STOCK/STRAIN: SUPPLIER: FEMALE MOUSE B6C3F1 CHARLES RIVER DATA STATUS* GROUP HUM NUH HUM HUH RECV HUM HISTC PBRF 50 50 33 50 50 50 29 48 20 20 20 20 19 LATEST OBSERV DATE 2 APR 3,74 3 APR 3,74 3 APR 3,74 3 APR 18,74 3 CHEMICALS C00511 1,2--DICHLOROETEANE CO0577 CORN OIL ABBREVIATIONS P04 - ORAL DOSE (GAVAGE,ETC) M/K - MILLIGRAM/KILOGRAM 5 D/S - 5 CONSECUTIVE DAYS/SEEK COMMENTS D AGE AT FIRST DOSE OR DOSE CHANGE STATED IN DATS 2) DATE TAKEN FROM LATEST C1GR/GROBP OBSERVATION RECORD 3} ALL IADRS HAVE BEEN SUBMITTED FOR THIS GROUP COL-GROUP 02-F074 TEST 02-F075 TEST TUMOR PATHOLOGY TOPOGRAPHY MORPHOLOGY NUH NUH WEEKS TOPOGRAPHY HIST TBA TO 1ST PERF TUMOR MORPHOLOGY HUH WEEKS TBA TO 1ST TUMOR MAMMARY GLAND ADENOCARCINOMA NOS 50 9 88.0 LUNG NOS ADENOCARCINOMA METASTATIC 3 88.0 MULTIPLE ORGANS NOS MALIG-LYMPHOMA HISTIOCYTI 8 69.9 UTERUS NOS ENDOMETRIAL STROMAL SARCO 2 81.0 LUNG NOS ALVEOLAR/BRONCHIOLAR ADEN 7 90.9 STOMACH NOS SQUAMOUS CELL CARCINOMA 2 81.9 UTERUS NOS ENDOMETRIAL STROMAL POLYP 3 91.0 MESENTERIC LYMPHNODB SQUAMOUS CELL CARCINOMA M 2 81.9 UTERUS NOS ADENOCARCINOMA NOS 3 90.9 SMALL INTESTINE NOS SQUAMOUS CELL CARCINOMA M 2 81.9 LUNG NOS HAMMARY GLAND STOMACH NOS ALVEOLAR/BRONCHIOLAR ADEN ADENOCARCINOMA NOS SQUAMOUS CELL CARCINOMA 48 14 7 5 61.9 LARGE INTESTINE 62.9 UTERUS NOS 36.1 KIDNEY NOS ENDOMETRIAL STROMAL SARCO 2 74.9 ENDOMETRIAL STROMAL POLYP 2 62.9 TUBULAR-CELL ADEHOCARCINO 1 61.9 SL 068401 ( c ( < c ( (. ( c 02-F071 VEHI 02-F081 DNTR US NOS OS NOS ADENOCARCINOHA NOS ENDOHETRIAL STROMAL SARCO SUBCOT TISSUE SQOAHOOS CELL CARCIHOBA 3 .7 URINARY BLADDER HOS EHDOHETRIAL STROHAL SARCO HOLTIPLE ORGANS NOS HALIG-LYBPHOHA LYKPHOCYTI 20 2 56.0 HOLTIPLE ORGANS HOS HALIG.LTBPHOHA HISTIOCTTI 2 90.1 LONG HOS ALTBOLAR/BHONCHIOLAR ADEN 1 90.1 LITER BOS HEPATOCELLULAR CARCIHOBA 1 90.1 STOHACH 90S SQUAHOOS CELL CARCIHOBA 1 90.1 BULTIPLE ORGANS NOS HALIG.LTBPHOHA LTHPHOCTTI LUNG NOS ALTEOLAR/BHOHCHIOLAH ADEN HOLTIPLE ORGAHS NOS HALIG.LTBPHOHA HISTIOCTTI 19 2 95.0 1 95.0 1 95.7 r r- r r r " i* v. .. ,r . l 44.0 74.9 C c { ( c ( c ( c ( ( SL 068402 ( l ^^1 NCI CARCINOGENESIS 3IOASSAY EXPER NTAL DESIGN STATOS REPORT BOV 10, 1976 2 CONTRACT NOIJBBR: AGENT ROBBER: LINK NOHBEH: 723278 C00511 020 BARE: HAZLETON LABS NABB: 1,2--DICHLOROETH ANE Hlf . ` r t: J/iZD SEX: SPECIES: STOCK/STRAIN: SUPPLIER: FEHALE RAT OSBORNE BHI BENDEL COL-GROOP ROLE |PREP RB * [NOBB [ PREPARATION* CHEB CONCENTRATION | AGE AT SORB PPH (PER CENT)| FIRST DOSE 1 ART ONIT RTE FREQ DORA |BIRTH DAYS [6 START [DATES GROOP SIZE DATA STATOS* NOR NHR NOR NOR SOR IADR TB1 AOTO REC* V NOR HISTO PBRF LATEST OBSERV DATE 2 01-074F TEST 350 I A08 C00511 1 COOS77 | 308 COOS11 i COO577 | BOB C00511 r C00577 50000 950000 75000 930000 75000 930000 ( ( ( ( ( ( 5.0) | 95.0)| 7.5) | 93.0)[ 7.5) E 93.0)| 66 122 192 01-075F TEST 350 1A08 * r BOB t [BOB r C00511 C00577 C00511 COO577 C00511 COO577 50000 950000 75000 930000 75000 930000 ( ( ( ( ( ( 5.0) [ 95.0) [ 7.5) | 93.0>| 7.5) | 93.0) [ 66 122 192 01-071F VEHI [AOI C00577 1000000 ( 100.0)| 66 350 t [AOI C00577 1000000 ( 100.0)[ 122 | AOI C00577 1000000 ( ioo.o)r 192 50.0 H/K 75.0 R/K 50.0 R/K P04 SD/W PQ4 5D/W P04 5D/W 56 [JAN 24,72 | BAR 30,72 701 | 420 [ 1 50 100.0 R/K 150.0 H/K 100 .0 H/K P04 5D/W P04 5D/W P04 5D/W 56[JAN 24,72 | BAR 30,72 70 [ 1 420 [ I 50 100.0 R/K P04 5D/W 150.0 H/K P04 5D/W 100.0 H/K P04 5D/W 56|JAN [HAR 70[ 420 [ 24,72 30,72 20 1 50 24 0 50 33 8 20 7 0 0 0 50 HAT 9,74 3 50 JAN 17,74 3 20 HAT 9,74 3 01-03IF OH TR r 374 i [HAT 31,72 20 [RAX 31,72 0 20 14 0 20 AOG 20,74 3 CBEHICALS CO0511 1,2-DICBLOROETHANE C00577 CORN OIL ABBREVIATIONS P04 - ORAL DOSE (GAVAGE,BTC) R/K - HILLIG RA B/KILOGRAH 5D/W - 5 CONSECUTIVE DATS/SEEK COHHENTS 1) AGE AT FIRST DOSE OB DOSE CHANGE STATED IN DATS 2) DATE TAKEN FROM LATEST CASE/GROUP OBSERVATION RECORD 3) ALL IADRS HAVE BEEN SOBHITTED FOR THIS GHOOP COL-GROOP TOPOGRAPHY 01-074F TEST 01-O75F TEST HAHHARY GLAND PITUITARY THYROID LIVER NOS SPLEEN NOS HAHHARY GLAND HAHHARY GLAND PITUITARY TOBOR PATHOLOGY HORPHOLOGY NOH NOH BEERS TOPOGRAPHY HIST TBA TO 1ST PBRF TOHOR FIBROADENOHA NOS CHROHOPHOBE ADEHOHA (T9 1 FOLLICDLAR--CELL ADENOHA HEPATOCELLOLAR CARCINOHA HEHANGIOSARCOMA 50 14 7 3 2 2 77.1 53.4 84.3 73.6 93.1 OTEROS NOS SOBCOT TISSBE/BACK ADRENAL STOHACB NOS SOBCOT TISSUE ADENOCARCINOHA NOS FIBROADENOHA NOS CHROHOPHOBE ADENOHA (T91 50 15 7 5 19.7 KIDNEY NOS 53.7 LONG NOS 50.0 OVARY NOS HORPHOLOGY NOR WEEKS TBA TO 1ST TOHOR EHDOHETHIAL STROHAL POLYP 2 92.0 EEHANGIOSARCOHA 1 92.7 CORTICAL CARCINOHA 1 73.6 SQOAHOOS CELL CARCINOHA 1 98.0 HEHANGIOSARCOHA 1 98.0 TOBOL A R --CELL ADEHOHA 2 77.9 ADENOCARCINOHA HETASTATIC 2 56.6 GRANOLOSA-CELL TOHOR 1 75.6 SL 068397 C r ( ( C (. ( ( (. 428 3 . 4284 . 4286: 4287. 4288. 4 289 . 4290 . 4292. 4293. 4294 . 4295. 4296. 4297. 4298. 4299 . 4300. 4301. 4302. 4303. 4304. 4305. 4306. 4307. 4308. 4309. 4310. 4311. 4312. 4313. 4314. 4315. 4316. 4317. 4318. 4319. 4320. 4321. 4322. 4323- 4324. 4325. 4326. 4327. 4328. 4329. 4330. 4333 , 4332. 4333. 4339 . 4336. 4338. ; 1 r. -i -i ff, ^ ,r ^^MPLETE-- NOT VEK IPX BD-~11/T 0/76 Mr.. .. . .. i t j 'vJ if '6 ri v. TABLE 3D. NUMBER OF FEMALE MICE WITH TUMORS BY ANATOMIC SITE NCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C005T1 1,2--DICHLOROETHANE --------------------------------------------------------------------------------------------------------------------------------------------------- CONTROL(DNTR) 02-F081 ANIMALS INITIALLY IN STUDY ANIMALS KECROPSIED ANIMALS EXAMINED HISTOPATHOLOGICALLY ANIMALS WITH TUMORS 20 19 (100%) 19 4 (21%) CONTROL (VEH) 02-F071 20 20(100%) 20 6 (30%) LOW DOSE 02-F074 50 50 (100%) 50 33 (66%) HIGH DOSE 02-F075 50 48 (100%) 48 29 (60%) INTEGUMENTARY SYSTEM* SUBCUT TISSUE SQUAMOUS CELL CARCINOMA SDBCUT TISSUE/GROIN SQUAMOUS CELL CARCINOMA ADENOMA,NOS SUBCUT TISSUE/LEG OSTEOSARCOMA 3 (6%) 2 1 1 1 1 t f2%) 1 1 RESPIRATORY SYSTEM LUNG ADENOCARCINOMA METASTATIC ALVEOLAR/BRONCHIOLAR ADENOMA ALVEOLAR/BRONCHIOLAR CARCINOMA OSTEOSARCOMA METASTATIC 1 (5%) 1 1 1 (5%) 1 1 11 (22%) 11 3 7 1 17 (35%) 17 1 15 1 CIRCULATORY SYSTEM NONE --------------------------------------------------------------------------- -- ---------- DIGESTIVE SYSTEM LIVES HEPATOCELLULAR CARCINOMA PANCREAS SQUAMOUS CELL CARCINOMA HETASTAT ADENOCARCINOMA METASTATIC____________ 2 (10%) 1 ^SYSTEM PERCENTAGES ARE BASED ON THE NUMBER OF ANIMALS SSCROPSIED 3 (6%> 9 (19%) T 12 1 __________________________________ 1 CONTINUED ON NEXT PAGE SL 068403 1 r c ( c c c c c c c c c c ( 4339 4340 4343 4343. 4344. 4345. 4346. 4347. 4348. 4349. 4350. 4351. 4352. 4353. 4354. 4355. 4356. 4357. 4358. 4359. 4360. 4361. 4362. 4363. 4364. 4365. 4366. 4367. 4368. 4369. 4370. 4371. 4372. 4373. 4374. 4375. 4376. 4377. 4378. 4379. 4380. 4381. 4383. 4384. 4386. n uplet s-Jn3t^\ri #W ' ' l' \ 1/10/76 CONTINUED FROM PREVIOUS PAGE CONTROL (UWTR) 02-F081 PANCREAS (COST.) ENDOHETRIAL STROMAL SARCOHA BETA ESOPHAGUS SQUAMOBS CELL CARCINOMA METASTAT STOMACH SQUAMOUS CELL CARCINOMA SMALL INTESTINE SQUAMOUS CELL CARCINOMA HETASTAT LARGE INTESTINE SQUAMOUS CELL CARCINOMA METASTAT ENDOMETRIAL STROMAL SARCOHA META COLON ADENOCARCINOMA CONTROL (VEH) 02-F071 LOW DOSE 02-F074 1 1 12 12 2 2 2 2 1 1 HIGH DOSE 02-F075 1 5 5 2 2 URINARY SYSTEM* KIDNEY ADENOCARCINOMA ENDOMETRIAL STROMAL SARCOHA META URINARY BLADDER ENDOMETRIAL STROMAL SARCOMA META 3 (6*) 2 1 1 1 1 ENDOCRINE SYSTEM ADRENAL ENDOMETRIAL STROMAL SARCOMA BETA 1 (2X) 1 1 HEMATOPOIETIC SYSTEM 3 f16%1_______________4 (20X>_____________ 13 f26Xl_______________ 4 {8*1 CONTINUED ON NEXT PAGE *SYSTEM PERCENTAGES ARE BASED OH THE NUMBER OF ANIMALS NECROPSIED SL 068404 (1387. 4388 . 4389. 4391. 4392. 4393. 4394. 4395. 4396. 4397. 4398. 4399. 4400. 4401. 4402. 4403. 4404. 4405. 4406. 4407. 4408. 4409. 4410. 4411. 4412. 4413. 4414. 4415. 4416. 4417. 4418. 4419. 4420. 4421. 4422. 4423. 4424. 4425. 4426. 4427. 4428. 4429. 4430.' 4431. 4432. 4433. 4435. 4436. 4433. 4439. 4440. |[^BpLETE--SO'C. [VERifel&D-^ 11/10/76 CONTINUED FROM PREVIOUS PAGE CONTROL (UHTR) 02-P081 CONTROL (VEH) 02-F071 LOW DOSE 02-F074 HIGH DOSE 02-F075 MULTIPLE ORGANS 34 8 flALIG.LYMPHOMA LYMPHOCYTIC TYPE 2 2 1 MALIG.LYMPHOMA HISTIOCYTIC TYPE 1 2 81 SPLEEN SQUAMOUS CELL CARCINOMA METASTAT ADENOCARCINOMA METASTATIC ENDOMETRIAL STROMAL SARCOMA BETA HEMANGIOSARCOMA KALIG.LYMPHOMA HISTIOCYTIC TYPE 33 1 1 1 1 11 MESENTERIC LYMPHNODE SQUAMOUS CELL CARCINOMA METASTAT 2 2 RENAL LYMPH NODE MALIG.LYMPHOMA HISTIOCYTIC TYPE 1 1 REPRODUCTIVE SYSTEM* MAMMARY GLAND ADENOCARCINOMA VAGINA ADENOCARCINOMA METASTATIC UTERUS ADENOCARCINOMA ENDOMETRIAL STROMAL ENDOMETRIAL STROMAL POLYP SARCOMA OVARY ADENOCARCINOMA METASTATIC GRANULOSA-CELL TUMOR ENDOMETRIAL STROMAL SARCOMA META 15 (30%) 9 9 8 3 3 2 1 1 15 (31%) 7 7 1 1 9 4 2 3 3 1 1 1 NERVOUS SYSTEM NONE MUSCULOSKELETAL SYSTEM NONE________________________________________________________________ ________________________________________________________________________ CONTINUED OS NEXT PAGE *SYSTEM PERCENTAGES ARE BASED ON THE NUMBER OF ANIMALS NSCROPSIED l c ( ( r c ( ( ( ( ( ( c c ( SL 068405 4442 4443 4444 4446. 4447. 4448. 4449. 4450. 4451. 4452. 4453. 4454. 4455. 4456. 4457. 4458. 4459. 4460. 4461 . 44 62. 4463. 4464. 4465. 4466.. 4467. 4469. 4470. 4471. 4472. 4473. 4474. 4475. 4476. 4477. 4478. 4479. 4480. 4481 4482.' 4483. 4484. 4485. '-Apy PLETE--HO? V ER1FTED?^1jl/10/76 CONTINUED FROM PREVIOUS PAGE CONTROL fUNTRJ 02-P081 CONTROL(VEH) 02-F071 LOR DOSE 02-P074 HIGH DOSE 02-F075 SPECIAL SENSE ORGANS HARDERIAN GLAND ADESOHA,NOS 1 (2%) 1 1 ALL OTHER SYSTEMS NONE -------------- ANIMAL DISPOSITION SUHKARY ANIHALS INITIALLY IN STUDY NATURAL DEATH* MORIBUND SACRIFICE SCHEDULED SACRIFICE ACCIDENTALLY KILLED TERMINAL SACRIFICE ANIMAL HISSING * INCLUDES AUTOLYZED ANIMALS 20 3 1 16 20 4 16 50 15 1 34 50 49 1 TUMOR SUMMARY TOTAL ANIMALS HITS BENIGN TUMORS* TOTAL BENIGN TUMORS 1 (5%) 1 (5*) 1 12 (24%) 12 TOTAL ANIMALS WITH MALIGNANT TUMORS TOTAL MALIGNANT TUMORS 3 (16%) 3 5 (25%) 6 26 (52%) 30 TOTAL ANIMALS WITH METASTATIC TUMORS TOTAL METASTATIC TUMORS TOTAL ANIMALS BITS INVASIVE TUMORS TOTAL INVASIVE TUMORS 6 (12%) 13 TOTAL ANIMALS BITS TUMORS UNCERTAINBENIGN OH MALIGNANT TOTAL UNCERTAIN TUMORS TOTAL ANIHALS WITH TUMORS UNCBSTAINPRIMARY OR METASTATIC TOTAL UNCERTAIN TUMORS t (2%) 1 *TUMOR SUMMARY PERCENTAGES ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ 16 (33%) 17 21 (44%) 25 6 (13%) 13 1 (2%) 1 SL 068406 I < ( c ( ( c ( ( c c c c ( c c (. 1 4488. 4490. 4491. 4492. 4498. 44 95.' 4496. 4498. 4499. 4 500. 4501. 9 J V 2. 4503. 4 504. 4505. 4506. 4507. 4508. 4509. 4510. 4511. 4512. 4513. 4514. 4515. 4516. 4517. 4518. 4519. 4520. 4521. 4522. 4523. 4524. 4525. 4526. 4527. 4528. 4529. 4530. 4531. 4532. 4533. 4534. 4535. 4536. 4537. 4538. 4539. 4540. 4542. 4548. KPLETE--HOT VERIFIED--11/10/76 - - 1--1 '--' * * TABLE 4D. HUMBER OF FEMALE MICE WITH HON--TOMOH PATHOLOGY BY ANATOMIC SITE 1ICI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C00511 1,2-DICHLOROBTHANE ----------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------- CONTROL(ONTR) 02-F081 ANIMALS INITIALLY IN STUDY ANIMALS NECROPSIED ANIMALS EXAMINED HISTOPATHOLOGICALLY ANIMALS WITH NON-TUMOR PATHOLOGY 20 19 (100%) 19 14 (74%) CONTROL(VBH) 02-F071 20 20 (100%) 20 17 (85%) LOW DOSE 02-F074 50 50 (100%) 50 44 (88%) HIGH DOSE 02-F075 50 48 (100X) 48 24 (50%) INTEGUMENTARY SYSTEM SKIN EPIDERMAL INCLUSION ACARIASIS HYPERKERATOSIS ACANTHOSIS CYST SEBACEOUS GLAND INFLAMMATION APOCRINE SWEAT GLAND INFLAMMATION SKIN OF EYELID INFLAMMATION SKIN OF BACK EPIDERMAL INCLUSION CYST 3 (6X) 2 1 1 1 1 1 1 *1 1 1 1 3 (6%) 2 1 1 1 1 RESPIRATORY SYSTEM TRACHEA INFLAMMATION LUNG THROMBUS ORGANIZED PNEUMONIA CHRONIC MURINE CALCIUM DEPOSITION 1 (2%) 1 1 8 (17%) 1 1 7 1 6 1 CIRCULATORY SYSTEM NONE DIGESTIVE SYSTEM 1 (5X1 2 (10X1 SYSTEM PERCENTAGES ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED 11 (22X> 2 (4%) CONTINUED ON NEXT PAGE SL 068407 c c ( c ( ( ( c c t c c ( ( t. 4545. 4 546. 4548. 4549. 4550. 4551 . 4552. 4553. 4554. 4555. 4556. 4557. 4558. 4559. 4560. 4561 . 4562. 4563: 4564. 4565. 4566. 4567. 4568. 4569. 4570. 4571. 4572. 4573. 4574. 4575. 4576. 4577. 4578. 4579. 4580. 4581. 4582. 4583. 4584: 4585. 4586. 4587. 4588. 4589. 4590 . 4592. 4593. ^HPLSTB-tHOT VERIFIEJD-^ll/IO/Te fi ri v. :Lr a !s 5 U fcj \j r/"j. ijV, 'j ------------------------------------------------------------------------------------ CONTROL(UNTRJ 02-F081 CONTINUED FROH PREVIOUS PAGE CONTROL(VBH) 02-F071 LON DOSE 02-F074 HIGH DOSE 02-F075 SALIVARY GLAND CYST LIVER THROHBOS ORGANIZED INFLAHNATION AHYLOIDOSIS ANGIECTASIS PANCREAS INFLABNATION STOHACE CALCIUN DEPOSITION HYPERKERATOSIS ACANTHOSIS LARGE INTESTINE HEHATODIASIS COLON HEHATODIASIS 1 1 1 1 t 1 1 1 1 12 12 11 1 1 5 5 1 1 URINARY SYSTEM KIDNEY HYDRONEPHROSIS PYELONEPHRITIS AHYLOIDOSIS URINARY BLADDER INFLAHHATIOH CALCIUH DEPOSITION 1 (5%> 1 1 3 (6X) 3 2 1 2 {4X1 1 1 1 1 ENDOCRINE SYSTEH KOHE________________ __ ____________________________________________________________________________________________________________________ CONTINUED OH NEXT PAGE *SYSTEH PERCENTAGES ARE BASED ON THE RUBBER OF ANINALS NECROPSIED SL 068408 4595. 4 59b. 4598 , 4599. 4600 . 4601. 4602. 4603. 4604. 4605. 4606. 4607. 4608. 4609. 4610. 4611 . 4612. 1F613. 4614. 4615. 4616. 4617. 4618. 4619. 4620. 4621. 4622. 4623. 4624. 4625. 4626. 4627. 4628. 4629. 4630. 4631. 4632. 4633. 4634. 4635. 4636. 4637. 4638'. 4639. 4640. 4641. 4642. 4643. 4644 . 4645. 464?. 4648. 4639. ; MPLETE --NOT V ERIFIED-11/10/76 \. ; ' ' r-------------------------------------------------------------------------- CONTROL (UNTR) 02-P081 CONTINUED FROM PREVIOUS PAGE CONTROL(VEH) 02-F071 LON DOSE 02-F074 HIGH DOSE 02-F075 HEMATOPOIETIC SISTER SPLEEN AMYLOIDOSIS HEMATOPOIESIS CERVICAL LYMPH BODE IHFLAHHATIOB MESENTERIC LYMPHHODE INFLAMMATION T (53) 1 1 7 (14%) 7 2 5 1 1 1 1 REPRODOCTIVE SYSTEM UTERUS HYDROHETRA INFLAMMATION OTEROS/ES DOM ETRIUfl INFLAMMATION HYPERPLASIA HYPERPLASIA CYSTIC OVARY CYST INFLAMMATION NERVOUS SYSTEM BRAIN/HEHINGES INFLAMMATION 14 (74*) 3 3 9 2 7 12 10 2 17 (85%) 4 4 13 2 11 13 10 3 41 (82%) 15 5 10 18 1 17 27 17 10 16 (33%) 10 1 9 6 5 7 1 {2%) 1 7 MUSCULOSKELETAL SYSTEM NONE SPECIAL SENSE ORGANS NONE ALL OTHER SYSTEMS 4 <21%) 1 f5%1 SYSTEM PERCENTAGES ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED 4 (8%) 12 (25%1 CONTINUED OH NEXT PAGE SL 068409 1)651. 4652. 4653. 4655. 4656. 4657. 4658. 4659. 4660. 4661. 4662. 4663. 4664. p V* -: PL ET E--NOT - A VERIFI i fcr411/10/76 ?Uei u u ij a # ti, a i a CONTIH0ED FSOtl PREVIOUS PAGE CONTROL (UNTR) 02-F081 CONTROL(VEH) 02-F071 PERITONEUM INFLAMHATION NO ASSOCIATED ORGAN NO LESION REPORTED A0T0LYSIS/80 NECROPSY PERFORMED 4 3 1 1 1 LON DOSE 02-F074 T 1 3 3 NIGH DOSE 02-F075 12 10 2 SL 0684 LO 21^. 2170. 2173. 2173. 2174. 2175. 2173. 2178. 2179. 2180. 2181, 2182. 2T83. 2184. 2185. 2136. 2187. 2188. 2189. 2190. 2191. 2192, 2198. 2199. 2207. 2208. 2209'2210. 2211. 2212. 2213. 2214. 2215. 2216. 2217. 2218. 2219. 2220. 2221. 2221.1 2221.15 2221.2 2221.25 2221.3 2221.35 2221.4 2221.45 2221.5 2221.55 2221.6 2221.65 2222.7 2223. 2223. S1PLETE-- NOT VERIFIED--11/10/76 TABLE 3B. NUMBER OF FEBALE RATS HITH TUB OR S BY ANATOMIC SITE SCI CONTRACT: 723278 HAZLETON SCI CHEMICAL: C00511 1,2-DICHLOROETHANE ------------------------------------------------------------------------- ------------------------------------------------------------------------- CONTROL(UNTR) 01-03 IF ASIBALS INITIALLY IN STUDY ANIMALS NECROPSIES ANIMALS EXAMINED HISTOPATHOLOGICALLY ANIMALS HITS TUMORS 20 20 (100%) 20 14 (70%) CONTROL(VEH) 01-071F 20 20 (100%) 20 7 (35%) INTEGUMENTARY SYSTEM* SUBCUT TISSUE ADENOCARCINOMA FIBROADENOMA HEHAKGIOSARCOMA FIBROMA FIBROSARCOMA 1 (5%) 1 1 RESPIRATORY SYSTEM LUNG ADENOCARCINOMA METASTATIC CIRCULATORY SYSTEM HEART MIXED TUMOR METASTAT * (5%) 1 1 DIGESTIVE SYSTEM SALIVARY GLAND SQUAMOUS CELL CARCINOMA LIVER HEPATOCELLULAR CARCINOMA HEHANGIOSAKCOMA PANCREAS HEMANGXOSARCOMA STOMACH SOUAMOUS CELL CARCINOMA 1 (5%) 1 1 SYSTEM PERCENTAGES ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED LON DOSE 01-074F 50 50 (100%) 50 24 (48%> 4 (8%) 4 1 2 2 HIGH DOSE 01-075F 50 50 (100%) 50 33 (66%) 9 (18%) 9 3 1 2 2 2 2 (4%) 2 2 5 (10%) 2 (4%) 1 1 21 2 1 1 1 1 1 CONTINUED ON NEXT PAGE 0fe8iU SL f ( ( c ( ( ( ( ( ( ( c ( 2226. 2227. 2228. 2230. 2231. 2232. 2246. 2247. 2248. 2249. 2250. 2251. 2252. 2253. 2254 . 2255. 2256. 2257. 2258. 2259. 2260. 2261. 2262. 2263. 2264. 2265. 2266. 2268. 2269. 2270. 2271. 2271.1 2271.15 2271.2 2271.25 2271,3 2271.35 2271.4 2271.45 2271;5 2271.55 2272.6 2273. 2275. I PLETE-- MOT VERIFIED--11/10^76 CONTINUED FROB PREVIOUS PAGE CONTROL (ONTR) 01--03 IF CONTROL(TEH) 01-071F LON DOSE 01-074F HIGH DOSE 01-075F LARGE INTESTINE HE8ANGI0SARC0HA 1 1 PRIMARY SYSTEH* KIDNEY TOBDLAP.-CELL ADENOBA TOBOLAR-CELL ADENOCARCINOMA LIPOHA BIXED TUMOR MALIGNANT EAMAHTOBA 3 (15*) 3 1 2 <* (6*) 4 2 1 1 ENDOCRINE SYSTEH PITOITARY CRSOBOPHOBE ADENOBA ADRENAL CORTICAL CARCINOMA THYROID FOLLICULAR-CELL ADENOMA C-CELL ADENOBA C-CELL CARCINOMA PANCREATIC ISLETS ISLET-CELL ADENOMA 9 (45*) 6 6 4 2 2 1 1 7 (35%) 7 7 10 (20*) 7 7 1 1 3 3 6 (12*) 5 5 1 1 HEMATOPOIETIC SYSTEH SPLEEN HEBANGIOSA RCOHA *STSTEM PERCENTAGES ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED 2 (4*) t (2*) 21 21 CONTINUED ON NEXT PAGE SL 068412 2276. 2277. 2270. 2280. 2281 . 2282. 2295. 2296. 2297. 2298. 2299. 2300. 2301. 2302. 2303. 2304. 2305. 2306. 2307. 2308. 2309. 2310. 2311. 2312. 2313. 2314. 2315. 2316. 2317. 2319. 2320. 2321. 2322.1 2322.2 2322.3 2322.4 2323. 2324- I PLETE--HOT VERIFIED--11/10/76 CONTINUED FROH PREVIOUS PAGE CONTROL(UNTH) 01-03IF CONTROL(VBH) 01-071F LON DOSE 01-074F HIGH DOSE 01-075F REPRODUCTIVE SYSTEM* MAMMARY GLAND ADENOCARCINOMA FIBROADENOMA UTERUS ENDOMETRIAL STROMAL POLYP HEMANGIOMA OVARY CYSTADENOCARCINOMA GRANULOSA-CELL TUHOR 5 (25%) 4 2 2 1 1 1 1 1 (5%) 1 1 15 (30%) 14 14 2 2 22 (44%) 20 T5 7 1 1 1 1 NERVOUS SYSTEH NONE ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- MUSCULOSKELETAL SYSTEH NONE _ SPECIAL SENSE ORGANS NONE _______________________________ ALL OTHER SYSTEMS NONE --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- CONTINUED ON NEXT PAGE *SYSTEH PERCENTAGES ARE BASED ON THE NUE1BER OF ANIHALS NBCBOPSIED ( r c ( ( ' i f C ( C t t ( ( SL 068413 t 2326. 2327. 2329. 2330. 2331 . 2332. 2337. 2336. 23 3S. 2340. 2341 . 2342. 2343. 2344. 2345. 2346. 2347. 2348. 2349. 2350. 2351. 2352. 2353. 2354. 2355. 2356. 2357. 2358. 2359. 2360. 2361. 2362. 2363. I RTS --NOT VERIFIED-- 11/10/7 6 CONTINUED FROM PREVIOUS PAGE ------------- --------- ------------------------ -------------- ------------------------------------------------------- ----------------------------------------------------------------------------------------- ------------- CONTROL(ONTR) 01-03 IF CONTROL(WEB) 01-071F LOW DOSE 01-074F HIGH DOSE 01-075P ANIMAL DISPOSITION SUMMARY ANIMALS INITIALLY IN STUDY NATURAL DEATH* MORIBUND SACRIFICE SCHEDULED SACRIFICE ACCIDENTALLY KILLED TERMINAL SACRIFICE ANIMAL HISSING * INCLUDES AUTOLYZED ANIMALS 20 2 5 13 20 12 8 50 45 3 2 50 47 3 TUMOR SUMMARY TOTAL ANIMALS KITH BENIGN TUMORS* TOTAL BENIGN TUMORS 12 (60S} 14 7 (35%) 8 20 (40%) 28 TOTAL ANIMALS WITH MALIGNANT TOHORS TOTAL MALIGNANT TUMORS 6 (30%) 7 8 (16%) 11 TOTAL ANIMALS WITH METASTATIC TUMORS TOTAL METASTATIC TUMORS 1 (5%) 1 TOTAL ANIMALS WITH INVASIVE TUMORS TOTAL INVASIVE TUMORS TOTAL ANIMALS WITH TUMORS UNCERTAINBENIGN OR MALIGNANT TOTAL UNCERTAIN TUMORS 1 (5%) 1 TOTAL ANIMALS WITH TUMORS UNCERTAIN-- PRIMARY OR METASTATIC TOTAL DNCERTAIN TUMORS *TUMOR SUHMARY PERCENTAGES ARE BASED ON THE NUMBER OF ANIMALS HECROPSIED ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 18 (36%) 19 25 (50%) 27 2 (4%) 2 1 (2%) 1 SL 068414 3299. 3300. 3302. 3303. 3304. 3305. 3308. 3308. 3309. 3310. 3311 . 3312. 3313. 3314. 3315. 3316. 3317. 3318. 3319. 3320. 3321. 3322. 3323. 3324. 3328. 3329. 3330. 3331. 3332. 3333. 3334. 3335. 3336. 3337. 3338 3339 3340 3341 3342 3343 3344 3345 3346 3347 3348 3349 3350 3351. 3352. 3353. 3354. 3356. 3357. 3358. PLETE--NOT VERIFIED--11/10/76 TAFLE 3C. NUMBER OF HALE MICE WITH TUMORS BY ANATOMIC SITE NCI CONTRACT: 723278 HAZLETON NCI CHEMICAL: C00511 1,2-DICHLOROETHANE CONTROL(ONTR) 02-H081 ANIMALS INITIALLY IN STUDY ANIMALS NECROPSIED ANIMALS EXAMINED HISTOPATEOLOGICALLY ANIMALS WITH TUMORS 20 18 (100X) 17 2 (IIS) CONTROL(VEH) 02-H071 20 19 (100X) 19 4 (21S) LOW DOSE 02-M072 50 47 (100X) 46 15 (32S) HIGH DOSE 02-H073 50 48(100*) 47 28 (58X) INTEGUMENTARY SYSTEM* SKIN OF BACK SQUAMOUS CELL CARCINOMA FIBROSARCOMA SUBCUT TISSUE FIBROSARCOMA 1 (6%) 1 1 1 (2%) 1 1 4 (8X) 4 4 RESPIRATORY SYSTEM LONG HEPATOCELLULAR CARCINOMA HBTASTA ALVEOLAR/3RONCHIOLAR ADENOMA 2 (4X> 2 1 1 16 (33S) 16 1 75 CIRCULATORY SYSTEM NONE DIGESTIVE SYSTEM LIVER HEPATOCELLULAR CARCINOMA STOMACH SQUAMOUS CELL CARCINOMA 2 (111) 2 2 2 (IIS) 1 1 1 1 7 (15S) 6 6 1 1 13 (27*) 12 12 2 2 URINARY SYSTEM NONE -------------------------------------- ENDOCRINE SYSTEM NONE_______________________________________________________________________________________________________________________________________ CONTINUED ON NEXT PACE *SYSTEM PERCENTAGES ARE BASED ON THE NUMBER OF ANIMALS BBCROPSIED SL 068415 r ( ( c c ( ( ( C ( ( ( ( ( i n rE--30? VERIFIE (1/10/76 CONTINOED PROH TIOtJS PAGE CONTROL (DNTR) 02-H081 CONTROL (VEH) 02-H071 LOW DOSE 02-H072 HIGH DOSE 02-H073 STIC SYSTEH* E ORGANS .LYHPHOHA LYHPEOCYTIC TYPE .LYHPKOWA HISTIOCYTIC TYPE GIOSARCOHA RIC LYHPHNODE GIOSARCOHA .LYHPHOHA HISTIOCYTIC TYPE YHPH NODE OKS CELL CARCINOHA HETASTAT .LYHPHOHA LYHPHOCYTIC TYPE .LYHPHOHA HISTIOCYTIC TYPE 3 (16%) 1 1 1 1 1 1 e cm* 4 4 2 2 2 2 6 (13%) 4 4 1 1 2 1 1 IYE SYSTEH IYSTEH IELETAL SYSTEH >ENSE ORGANS 1 SYSTEMS PERCENTAGES ARE BASED ON THE NUM3ER OF ANIHALS HECROPSTED CONTINBED ON NEXT PAGE ) 1 ) 1 SL 63/<l6 ) 3411. 3412. 34 io. 3415. 3416. 3417. 3417.1 3417.2 3418. 3419. 3420. 3421 . 3422. 3423. 3424. 3425. 3426. 3427. 3428. 3429. 3430. 3431. 3432. 3433. 3434. 3435, 3436. 3437. 3438. 3439. 3440. 3441. 3442. 3443. 3444. ^^PLETF. -- SCT VERIFIE0-.il/1O/76 ^' CONTINUED FROM PREVIOUS PAGE --------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------- CONTROL(USTR) CONTROL(VEH) LOW DOSE HIGH DOSE 02-M081 02-H071 02-M072 02-H073 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- AUTOLYSIS/NECROPSY PERF/NO HISTO 1 11 AUTOLYSIS/NO NECROPSY PERFORMED 2 1 3 2 ANIMAL DISPOSITION SUMMARY ANIMALS INITIALLY IN STUDY NATURAL DEATH* MORIBUND SACRIFICE SCHEDULED SACRIFICE ACCIDENTALLY KILLED TERMINAL SACRIFICE ANIMAL MISSING 20 12 T 7 20 9 11 50 39 11 50 29 21 * INCLUDES AUTOLYZED ANIMALS TUMOR SUMMARY TOTAL ANIMALS WITH BENIGN TUMORS* TOTAL BENIGN TUMORS 1 (2*) 1 TOTAL ANIMALS WITH MALIGNANT TUMORS TOTAL MALIGNANT TUMORS 2 m*) 3 4 (21*) 4 15 (32*) 16 TOTAL ANIMALS WITH METASTATIC TUMORS TOTAL METASTATIC TUMORS 7 (5S) 1 1 (2*) 1 TOTAL ANIMALS WITH INVASIVE TUMORS TOTAL INVASIVE TUMORS TOTAL ANIMALS WITH TUMORS UNCERTAINBENIGN OR HALIGNANT TOTAL UNCERTAIN TUMORS TOTAL ANIMALS WITH TUMORS UNCERTAIN-- PRIMARY OR METASTATIC TOTAL UNCERTAIN TUMORS *TUMOR S3MHARY PERCENTAGES ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 15 (31*) 15 22 (46*) 25 1 (2X) t 903. 904 . 906. 907. 908. 909. 910. 912. 913. 914. 915. 916. 917. 918. 919 . 920. 921. 922. 923. 924. 925. 938. 939. 940. 941. 942. 943. 944 . 945. 946. 947. 948. 949. 950. 951. 952. 953. 954. 954.1 954.15 954.2 954.25 954.3 954-35 954.4 954.45 954.5 954.55 954.6 959.65 956. 955. PLETE--HOT VERIFIED-- 11/10/76 ! tl fe t.-vt. .-ii * ,. : / j ti r; s. TABLE 3A. NUMBER OP HALE RATS NITH TUMORS BY ANATOMIC SITE Hd CONTRACT: 723278 HAZLETON NCI CHEHICAL: C00511 1,2-DICHLOROETHANE CONTROL(DNTR) 01-031H ANIMALS INITIALLY IN STUDY ANIHALS NECROPSIED ANIHALS EXAMINED HISTOPATHOLOGICALLY ANIHALS WITH TOHORS 20 20 (10056) 20 6 (30%) CONTROL(VEH) 01-071M 20 20 (100%) 20 4 (20%) INTEGUMENTARY SYSTEM* SOBCUT TISSUE FIBROHA FIBROSAHCOHA t (5%) 1 1 RESPIRATORY SYSTEH NONE CIRCULATORY SYSTEM NONE DIGESTIVE SYSTEM SALIVARY GLAND CARCINOMA,KOS LIVER SQUAHODS CELL CARCINOMA HETASTAT HEPATOCELLULAR CARCINOMA HE flANG 10 SARCOMA PANCREAS SQUAHODS CELL CARCINOHA HETASTAT LEIOHYOSARCOHA HETASTATIC HEHANGIOSARCOHA STOHACH SQUAMOUS CELL CARCINOHA LEIOMYOSARCOMA HEHANGIOSARCOHA 2 (10%) 1 1 SYSTEM PERCENTAGES ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED LON DOSE 07-072H 50 50 (700%) 50 20 (40%) 5 (10%) 5 HIGH DOSE 01-073M 50 50 (100%) 50 20 (40%) 6 (12%) 6 2 7 (14%) 13 (26%) 12 1 1 1 14 1 7 12 5 10 29 1 3 CONTINUED ON NEXT PAGE c c c c c ( c c t ( ( SL 068418 1 ( 959. 960. 963. 969. 965. 979. 980. 981. 982. 983. 984. 985. 986. 987. 988. 989. 990. 991. 992. 993. 994 . 995. 996. 997. 998. 999. 1000. 1001. 1002. 1003. 1005. 1008. PLETE--NOT VERIFIED--11/10/76 Ik:_______________________________-_____________ CONTINUED FROM PREVIOUS PAGE CONTROL(UNTR) 01-031M CONTROL(YEH) 01-071M LON DOSE 01--072H HIGH DOSE 01-073H SMALL INTESTINE ADENOCARCINOMA FIBROSARCOMA 1 1 1 1 OSINARY SYSTEM* KIDNEY TOBOLAS--CELL ADENOMA TOBBLAR-CELL ADENOCARCINOMA LIPOMA LIPOSARCORA HAMARTOMA 1 (2*) 1 1 6 (12X) 6 1 1 2 1 1 ENDOCRINE SYSTEM PITUITARY CHROMOPHOBE ADENOMA ADRENAL CORTICAL ADENOMA CORTICAL CARCINOMA HEMANGIOSARCOHA HETASTAT 3 (T5X) 2 2 2 2 3 (15X) 2 2 SYSTEM PERCENTAGES ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED 3 (6X) 6 (12X) 14 14 2 1 1 CONTINUED ON NEXT PAGE f r t r c < ( c c c ( f f SL 068419 t c 1008. 1009. 1010. 1012. 1013. 1014. 1015. 1016. 1017. 1018. 1019. 1020. 1021. 1022. 1023. 1024. 1025. 1026. 1027. 1028. 1029. 1030. 1031. 1032. 1033. 1034. 1035. 1036. 1037. 1038. 1039. 1040. 1041. 1042. 1043. 1044. 1045. 1046. 1047. 1048. 1049. 1050. 1051. 1052. 1053. 1054. 1055. 1056. 1056.1 1056.15 1056.2 1056.25 1056.3 1056.35 1056.4 1056.45 1056.5 PLETE--NOT VERIFIED ---11/10/76 * , 4i"" "* CONTROL (UNTR) 0T-031H THYROID FOLLICULAR-CELL ADENOMA FOLLICULAR-CELL CARCINOMA PANCREATIC ISLETS ISLET-CELL ADENOMA HEMATOPOIETIC SYSTEM MULTIPLE ORGANS LEUKEMIA LYMPHOCYTIC SPLEEN SQUAMOUS CELL CARCINOMA SETASTAT LEIOMYOSARCOMA METASTATIC HEHANGIOSARCOMA 8EMANGIOSARCOMA HETASTAT THYMUS SQUAMOUS CELL CARCINOMA 1 (5X) 1 1 REPRODUCTIVE SYSTEM* MAMMARY GLAND ADENOCARCINOMA FIBROSARCOMA FIBROADENOMA TUNICA YAGINALIS MESOTHELIOMA 2 (10S) 2 1 1 NERYOUS SYSTEM NONE MUSCULOSKELETAL SYSTEM NONE SPECIAL SENSE ORGANS NOSE ALL OTHER SYSTEMS MULTIPLE ORGANS ADENOCARCINOMA METASTATIC CONTINUED EBON PREYIOUS PAGE CONTROL(TEH) 01-071 PI LOB DOSE 01-072H HIGH DOSE 01-073H 8 (16X) 5 (10X) T 1 3 t (5*) 1 5 (105C) 3 2 1 1 12%) 4 (BX) 4 c r c c r c c c ( t c f SL 068420 1056.55 1056.6 1056.65 1056.7 1056.75 1057. 1058. ^PEhangiosarcoha ABDOMINAL CAVITY HEMANGIOSARCOMA --------------------------------------------- *SYSTEH PERCENTAGES ARE BASED ON THE NUMBER OF ANIMALS HBCROPSIED 3 CONTINUED ON NEXT PAGE FV"' ; SL 068421 1060 . 1061. 1063. 1064. 1065. 1066. 1081. 1082. 1083. 1084. 1085. 1086. 1087. 1088. 1089. 1090. 1091. 1092. 1093. 1094. 1095. 1096. 1097. 1098. 1099. 1100. 1101. 1102. 1103. 1104. 1105. 1106. 1107. COMPLETE--HOT VERIFIED -- 11/10/76 \t >4 a t> ^ " CONTINUED FROM PREVIOOS PAGE CONTROL (U1TTR) CONTROL (VEH) LOW DOSE HIGH DOSE 01-031H 01-071M 01-072H 01-073H ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ANIMAL DISPOSITION SUMMARY ANIMALS INITIALLY IN STUDY NATURAL DEATH* MORIBUND SACRIFICE SCHEDULED SACRIFICE ACCIDENTALLY KILLED TERMINAL SACRIFICE ANIMAL KISSING 20 11 5 4 20 16 4 50 48 1 1 50 50 * INCLUDES AUTOLYZED ANIMALS ------------------------------------------------------------------- TUMOR SUMMARY TOTAL ANIMALS WITH BENIGN TUMORS* TOTAL BENIGN TUMORS 2 (10*) 3 3 fISSj 3 7 (14*) 10 TO (20*) 17 TOTAL ANIMALS HITH MALIGNANT TUMORS TOTAL MALIGNANT TUMORS 6 (30*) 8 1 (5<) 1 15 (30*) 18 16 (32*) 22 TOTAL ANIMALS KITH METASTATIC TUMORS TOTAL METASTATIC TUMORS 1 (2*) 1 4 (8S) 7 TOTAL ANIMALS WITH INVASIVE TUMORS TOTAL INVASIVE TUMORS TOTAL ANIMALS WITH TUMORS UNCERTAINBENIGN OR MALIGNANT TOTAL UNCERTAIN TUMORS 3 (6*) 3 TOTAL ANIMALS HITE TUMORS UNCERTAINPRIMARY OR METASTATIC TOTAL UNCERTAIN TUMORS *TOMOR SUMMARY PERCENTAGES ARE BASED ON THE NUMBER 0? ANIMALS NECROPSIED ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ c e c c c c c ( c c ( ( ( (. ( ( i SL 068422 ( PC Out..... .... .. ... T ... - '/w _..yL.. .. .. z/. /i>o .1 2- --.......-%^~ ---------------------- tfiJcu ................ (h P*vtw { %;__________ ._.. . _X___________ // .WaJ'I <5 &/ /ro fa _.. C>/ .. % _________ 2f?........ ..... _ .... ..... /h. ..... . . ._ iis-- ------------- -- - - -- -.%*__________ -- i i| rS* ^ 1 T -- --------------------------------------------------------- % i/f/>/ _______________ 0_. Tf w--*+_____ + t. .. I1 - s<L<u>w -/A----------- ?/ Si 7 %r // // f / 'UL / V" /v; SL O68453 % Jh 'Td A* jj/rldi- o**1 /Jci n'A prtfui A//4S4- ~SAjtM. J Jtytyh____ '/5#... tf&rs --Mt-h t _-??V 2. /?/f * " __ ' ~/at> -//f sLc^Ul f. 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P* Q/^sit--iv---ty*{* --L-t-A--A--^-u. x. / / / ' ' h(b CPjl ' .-"' '/ Cu4~L *-A-d' &/' A7 Al'-' L-6'. -C 7........ ,Ly yP. r<>. -t'AA'jc, i 'w -^2^ P%.S*r./r j 1^/yC ' j j *rr/f yA*r - st t. *-~1T_______ ,, yty*^ -/Syi-r-^y // - JtPA&i2^AstLSl4 l ASyVM.y-tlj) f~Y* CA->t. -AsdTjiAi, C7 &A~ i/T, , , d /\jO A t-tt-fl y *+-- , /%y VTj 1. y y!l *T Pyy.^^ ~ff A^A-PPr^A . --/P Copyright 1988 Franklin Printed in U.S.A. Reorder No. 4013 SL o68428