Document LpXbw3pwYOKBpVwgE4rjpn2og

RdLATORY TOXICOLOGY AND PHARMACOLOGY 21, 211-215 (1995) 1Talc: Consumer Uses and Health Perspectives Bethesda, Maryland, January 31 -February 1, 1994 Co-Sponsored by: The International Society of Regulatory Toxicology & Pharmacology and The United States Food and Drug Administration Rapporteur C. J elleff Carr Professor Emeritus, DepaUrtnmiveenrtsoitfyPohfaMrmaarycloalnodg,yBaanldtimExopree,riMmaenrytalalnTdh2e1ra20p1eutics, School of Medicine, Received October 1, 1994 WJJJJGSWDDATJHCADGCCECPWoRMMCMKKKDKOOoaorHeAH.EdaohoraloaaheaaaIe.ktHiSiihaCmsJiNoRTcRnturlvnlbnaybonrRsDEEDeNHnnnBHrhyhleIlIIgorienemrnLiLPpSSnSaF,eaisAoiiEanirAalalHhaeacLTAETDEaeBnlDBipvERdtSeontEDtiOEOmm.lsLFooaMaLAaCelEWILPzBdth.aFT.BBPPNLauFonRkg.tHvF.EaDH.CHEDCDraE..ASrJAarlAFpeeFera.KBE.EohSrC.rBeBoielLomztuNrrJdellDRiUHRALweapiuFl,ni.Earrcra,,sLeesaaoURaaLTapsd.aiIaLBorttciTe,RDyl,mn,pSIgEoSch,hnClJkuu,ErirOodwha,.SUa,aEnSS-ghe,octez,G,Wooesl,TRU,NinES,Dtnve.,n,siyloSaHPalSIHwUCtOp,L.GnE.ihSIC,,Ueecsnu,nS,.tsfp,oEUEDCaos,TiiienUsymluoUk.T,.etF,zee,RiUlcSEkWiHo.thse,,MdeJuonFcnrhSv.oao,.DmsSr.eiAdogUmhKftei.eooESStkrt,UC,eiv.F.aeahsmgrMJydoe.feP.LhbF,amPetIlnSyinsioFneordaiiLcntrreForiR,&Ui.inarCio,ossohiT,otCccs,rvLo&orokedRyoIrFsoCneii.nEchIoeCdnUoDoacy,scitn,dneltooirils,ayl&edtDa,fmuaeov,g&RNaacrnsoefoolMa&rn&,dloeKuai.vr.Ir&rpinKrdgeS,rtDenvrkefiugnE&Dyjimaocw&&assJlDsaCrencg&,rWDohnn&reA.itro.Drane&uGletrCi,gayuDGARsaryhYndDrCJsiTtgu-e,lDgSinasuoiraaPedsnaoeomuPgtprSoorckmtSg-AmylyswarmimAsrhaatur&co,onsKaiAtk,nohndbplApSnghrnomgMdnbN,inmoTeAodiaolnmancioouSsslmdee,gAflNtsefememnehnosioedoiioldtmPiltCngscsdwNisdCeg,oienle,nrlsrC,int.ehnioeirnismoaodowriovaMCWcosniNPnrJTi.rvsIC.anilts,e,f,ant.,,nitotoiesiioa,uteooa,stnsrsoloPlYgCCtcMrlCrNliblrduCmratorsrfoiPno.naCesoukraoosa,hiamitrCetePgesi,nt,ircaon,bhtieclnalniitswSluirykouaaue,OnluctcionvedNcnWcaRioimoCmnrlnboiigtstcnoaoeihWlntehoeunY,,lScnaltaiePt,cbniCirnHseo,oare,toocncrrIatsCi,o,rh,aotrniWnoawhnrhaeRsoVhcuKPH.kt,NcFl.oW,Caih,tauPidoriai,ni.r,aoCneMDilrc,eSy,tcueWWlsoatgnNgalaneaO,kwhnahcACN,Odsgtailssviae,ttoiriNnhthuMn,tNseaernnhihowsnoAYiiil,cfyrewsLisghalo.lni--na,ot,olietewtItiasngalCNd,oYn,roDnlN,aYnatdnEkicnoDinJgMoensCIseot,d.r-ep,twynon,itCwroSkNnara,icn,DkSdnasgr.,K,,eYkD,eeC,Yyl,GwNeoimaySWloCDlMamrenlkreiJkmnoCioksiwi,se.lrad,clcalrgoNNhsmNosniYgiaoene,ageoyywrsanwNritBknn,herYYNwaCooneraJrcwkrkehorJ,lsieneWryasaesyhing and1PHreesaelnthtePde,risnppecatritv, east, tNheIHIn, tBerenthaetisodnaa, lMSDoc, iJeatnyuoafrRy e3g1u-lFateohrryuaTroyxi1c,o1lo99g4y. and Pharmacology/U.S. FDA Workshop on Talc: Consumer Uses 211 All riCghotpsyorfigrhetperdod1u9c9t5iobny iAn0ca2an7dy3e-mf2o1irc1m0P0rr/ee9ss5se$,rv6Ien.0dc0.. 212 C. JELLEFF CARR JTJJJJJJJADTDJAGFGSSKSCEACDJDADMCMGEREMKBMGFLNMKMBRBISWGGRBRRLNPLRRMOAOEOOOOaHaOetAHAotcRROtrILOR.UrO.A..dalirleoroooeehaeoAeeaiFCanNHOiaaanHHHSalHRaiyaceeaFROoRUaUUaNITkWPrWHooaNbwTBnoRvNngnlnnFwornRHErrMLldrrINnkNNNNNRpnpOOnnHntMnIirHCCAMleRfraEIoCEBideIeacTmaaJ.yJcPrvInISAkntyhNnha.EdIAltfLkLkiaLOaRPEEUgrRsELcytkEEoPl.llHHMoCADAeaiWiaH.eLRDGrleeBYeLAPnMntrDTSCrRYdIGTReddLReFRGnRnSlTSJM.mSVSHs..CODl.yaEeRnMnOIN.oScSi..drIn..mAcP.aTOccEOJaDoeTcTeMLJy.oPK.OjER.CFLrHWLhTOWGEMopGe.iKpSAn.E..GER.aeMMnhnBDimRcSWuT.bs...sML.rRr',E.ikaaDlaa.gubwPRMioSHTWaEeW.p.GOrL.eg.eJeL.oImystVgil.i.oLRSRMoHENlpmniaSEMn,Heln,dorLefohVScGtnkrO.nafoMoHleMHnclGlulHeAEelceNCaT.SoHRerKgc.ToReonOa,SaGSrhiCATaooskoEubn,DeL,esenrdni,SeiTrMtAcRHaNDends,oLeThEehoil,TadrsvatFegEyTUNs,MUrliralbSglM,roWRle,oeee,,ksTHARHNtrcsdLrex,,nbAAFJnn,daoseySJhRiNa,Ge,as&TsnCstOasGhlrt.r,,.tLAieUiNt,oiOu,REyTRem,MrNSEee,LtEhe,sree,lMHltt,,NnzHtEhwC,eCtnd,beoRiOCBigzhRl.,NsrKU.Sy,LhLA,RgJ,r.sFUulnin.alye,UaeteUReKrNezoClsASe,tg,c.oolnTiWU,r*eTrtoT,,,Feu,uF,UazNrm,ovn.eiUn,,cu,,gn,a.e,Cb.OJEo.TCa,nJS.PeisE,Pn,N,eaTsShNPM.mhBzUStoeoS.hSnaUDmm,ITM.olnosS,oLobsiteSs.G.S,N,nCRUhoeoS.lrotnrh,.enon,eaS.niiccoBbueVn,.sShh,UthkLnCrat,.otiEnogoanebn.elF,SesdUnoirBJet.ah,nd.scFan*YCiFrmlpTMPerndrnahSUumcgaParocieoesTFT.uaxoytUnloFkeP.utC,uI&Fpvtnyio.&rG,,oucutnui,.eeshlrrzIicnenyeranxSngeer,sPooih.FeleAoeteeoroooUrPoIoooonleomrPSdecvtllooeWrSolcuNFK.ciho&drd,ydegAGJnsTeitrrSodeolancmond,tDlcCs.isene&Ulrhdnsa..rcindtbcasoa-Klissio&FvioCrs,oeS,am&,dtmdltcareraer,eceIciclnC,uo&,hFnier&craseicuoUemnEhowd&nobn.yySsos&&atJBsitaORalcoaIlouie,Icrre&urtfCtrMoymttnliliubdnGicctpnvlonoDTFuoenlsiCtleiotgeeil&CRaCvretDlsmalDAot&J&cpi.eapysoeo&UmtsytoStcrDdYghlrieibonisDa,cooeE&frD&rieakadC.aoeo,ectotlorAttgrmm.reiUueocf&oCn,keumroooD&enMenyv,iyrPlrElnnnavJu,rsIGhrun,inIrhaooWeL&rdDIssnrrrtgndinJsuEeninteefmnToCcuatnog,CbougrlnilvoovEiivkrvnmIlBinioaeamorGsda,glclTcDoegtimruycgLalnoVnlnDAthgc&ahn,oeaIJsefeeiooriD,vymnAkun,ero.Aihrtuahf.pnLn-gcehinaovii,tDAtiy,rl,,nuRlcreimlN,redpoeAgrlaCIAmcenimugln,eodoaaoroTbscUdIstCimuD,peanrCcnsnBOrcuCsSaodomAladMrrrtuTnM.,iiead.gelsn,nimfdNmmoletgas,oos,Alioi,cR.tgcsu.eonncbksugmre.raoagownodsrtntimNiy,wSyaNmiicrE,..tnAWoSBtuhleieoeyglotNtyiaKdAnoief,nimltna,rtrn,n,Cma'iy.Mnl,eyhninfsAaIieonscdae,deng,e,i,srrkontri,mmaWniCste&NdntneetM,anogBY,peNitininirstoMwsiirigtw,CiiuHdaLCuIfntIItrroiseasocAw,zcIgm.hCsonUtsoiiitigieodinEIgieololns.neMmytnnmteaolftnno,HJo.rsnCnrhadsnoleonohnaeNrinledrrrt,Jcrw,looscirriw.aactHYnb.odtCccsoBnwrilieaNs,avcnsan,kts,naorntaei,.reetb.mr,rdaLnC.Dsetseooi.toay,,nohp,.Naai.yl.,Cloraas,nrtpaorCaruiNtFinatsePR,litVgR6ws,Yl,rninortiYsiianoSliuANrulAldsaireottMdoLltYnenne,owtiPaaosnrtWieMkLoseatoiEo,l,iaoItilNeoongmasanoeCotrndsnrroastowaliaohonto,tnnnIiecrcirraFoycYtlaarrealotanMMsag,sansnnscn,tragJeo.riitnokcne,knkno,tkdPkhaennstnwn2nroVasirtrtoiRhliw,toectwrs,.Cnrv,,iknCdWY,n,,a,rrneieBiiaRtaty.Cs,aGda,e.roa.enhaOrSecifii,ooieDa,,,asNNCui,tshoiolPnRkgOsNlhTsonconooasLnalisJ,hBoonaM2rautntlntflMclslNk,rnarCEkeaWW.oee,norsWeoceofncsidekoieihemgnsn,laRko,tiasoggtot,Cytr,k.mxnetewcsy,rhcGerasnr,,iwRoW.,ot,idcannPa,aoaovmnatdayad.kseltn,NMWwiNsaCnyABonpohCaehcMiniWsnscesvlNWWndu,seiiteMnltoOiiYvsn,aeuchethYsehskieoitBylgaaoaoncsccRotwaMlseeciaCfasYiowv,ioiwsriaiMohnshatltlsAtracnrn.gnn,ondnowooiokseenCsierSiorsrihanyeo,hDlrisceonsgo,gchagk,n,strcllJInahMklirplrliroyeoyYidltsuC,neaahlnit,kCatnsiketIs,gs.oisCMrYsclaooklown.notcodnnivia,beBraagsnviIltat,nGoDrtcno.ngnsnoiriolacsrguMiiralatin.NdunenlliruclSkd.ioo,'e.t,gyenlcCtriaornsdf,,kroaueRonemeyonntaoglDshDeyDrtlia,onS,EtOownir,i,i,rr.a,alueoCcnCng.aCnnkyiSM,dnFfsDMrNshnWgifdinliyDkoegDYaiallal,taACcedolitaaloaoCBnmCletrwarfWnrlssrnfdyrimnyadakhd,olJaldai.inaaoaernsVn,nksSrnhWged,,s,NdiLtrenoaRNN6meygnsoweehto,3cowwinUkDJnntveg,GJCYirtelDooslreernCs,kyeMy ary TALC: CONSUMER USES AND HEALTH PERSPECTIVES JWBEAARRERInoneIFCLNvnnnFHLeRSaeAIGrTEAlRWl.YdMLDyWo.JYZZZ.lWyOaaaWvlUyvzKeiUReeannAIL,ndd-RCUFGsoIeKA,krnas,CNIki,R,Uv,aAiLRe,C.rmSuErtUaes.zTeirn.eTFStr-ncyiW,.oecaAooCracadf.nPolAMlM&saaHmmact.iDeeereeWary,trniillucIcattonhssganlcv,ACdAF.e,I,conodnCtCr,umcipornIo.io,annldnlrncTeaiaA.bsg,htttliueirAlororieaPnantyelt,.n,aaiFocrNDNnkenoteea,,ar,wwykMI,vWnsGiJ,caYlae.lerMo,esroyr,hsBrlokeaCigrn,nyniootaNgdaontenkonwlaney,cntY,DicoNCurketw York 213 EXECUTIVE SUMMARY ogaodttlcaDtedogsoiaettpsesctwttiPri(inmiioonihoahnsoandtCeaptgrnaonxnvaiifrfreoyrtagralxglasseefcaemfoeTlTynenOApdiodstItcrucTntrhosccineldimaldiann,bhoaaiwcels,gchhgucdsamuuirtu(FfzdloeeoktnultFeadanyJoemtarI,cildeieatssefeeomnbArisshvoaedSasAcnmexhefldritvssneaderlmSptwcoraaa1remeaerlhnewndeipiueR)eaibdngioiseddsesonloeogl9trcgateseustdonduectysdvimigcoa9rTcmaecnysandnsrtrefgrncpsca,(icnoii0airouaeitpd,sudemoroNaPuaoeocnasogetrebakotoiuldfp.nimendaoslwtnhlynnfoUafrdccmtits)nysfpperseTerl,cofhyewsrrwi.knecdienhourc,aoi-itoerf.tetrue.sml3apaePnacoSeaoAmdhisigoeoenlfandnsastshmcnacrol1lasjenstp.rrfs)ereipssAgfiuvectfuioleisiaenwnmaen-nnhniredtsatfsaA.teptPRfacsotsbrFoikoehptgcoesewhssdtegtiahpetrneieittaehcnelrofhievseiuoehderrlqsuoedcyepsnsidtfantfraajmsraagroneb.sucreigtedunrsoitysteiorgoebbyclterbeusrtouoltrhnrsgnmiraosaimpumfiflociaolwnmeuyTouetrpemnlehcot(toiaorpelgorricaeagtetausseenbFfesiaociaahaalreaanfrhhaitht,croalvfinlrnfctrstlsDocsltnypodseecsorsiaoaearlhaualiylrmtaettoptoekceps,.tr-roeotsaletsf,rAlcttssplsofshocynteoercpeecssigh,gvnunioca1tpic,itqdaefoosveu)t,vsstxroiaosnuiehy,angchTrhuu,anoussessetrmnisleifelo(teeDeu1afldtlereihpnmbstwoeaenavtelrCtoaitiooahoron9rethfycnehrllpeoiadslxvtrwdioroifanniiaplieono9oTe.eelyo,tgbxniaofeeoccfidacce.aotwdsc4otitldarninFfsiepegsaJrlohagachevettyeootctCfogri/tl.FtotnueeftAiwnhliesdocedknoyaawlofhmigookacsbpoNrrhtarddoicoeolnlsrttf)uo.eiisinrnenvoissucetodsslgenunuhecr,nsncuoahuordo,amrvp,geuaecPglgeytragloaesk,amtaemfaeswistycndreiigilrtidiisbErtt/pehcensstptscitoitcavnoehguciuouehioyyeulshoi.ts,tnednUonxpnescndefoaouwirdhfrlautanidonoorcencariaoadBeyedasarnalsy.esnmctDaitpwoasrSanatitnsgtrtoolmhneseeseaoaoopesd,ohrPfttocct.re.faanas,Tsdedioxoyibtfdlraa.rffeTetlnofhtcnnoftseayEeniepFereoctltoortpootetconiaepeo.ygiptnhcchyiGeroxeeIompfmroiorfucaxtfrttiaiooisidgeEnaescrsiooaohrzsalmshdnp/eppecnpgttls(pmeaihartmtdltfdaxcanisamvuteFocodsnmoeseeucnearotsshsantuutlpmtr,emad,lfgDacsi,pslritedrtticracsaieoaasiencziotileouanutuiitteecdogeoissionAniinentnagaeehtgrrenrncrmntadopiooaistiesirrtddlngdlydiyodgneecessss--)tl,,,ff dcscTqwctodtgttotsccccSntUitifittitftlmflmffialauanuiidonnhhhooouuouaooooahgaefurelcemohelilnmneaeeaerhrtlrrranlamltrmmfyTsnDAaIciicltnreooiteemtddinmientogesheattlceltshRimnhstheo,srgNrsglete,mdosnarsdctrfleetie.neeeeoe,ihuayeoreaiiaie.rfwnettnadfacnphnTrnosrndiaviaaicadx,GomtDtnlpnsymdxtlpUnrf--.ilh-ydgrnlsorrtopeydpeiPylsiolueolsoociSirrmeyiDraiadgeecHireaenaptnmriroola.ontrnmanntblsftmtntpbcvreaclntldiiereorsehngisidebuarguaBeolsiuqin.osenfhonCelryouveribeaasac,a.utalsttrlyfscseelmthuhnaroaahneoepstrmasdRyit,asoiOlcciotxptlsoehtsheeutnsaot,uosas,lnosst5eauotueuhunpouiaapiaclacspbesir,lornuvtg0srottodvnoppiarseerfmaestesllaso.azrriitrnerttnse,efiifataeftsihntsoedosuahss0natueaflecehricilihaeiecrialaenysnuitccvnsmn0doFtrvuwsd.fnboio(.emlhetdoenhy.drutisdtesn0eFodend3tsnelbddfyeaiInseensieosleIylCnudntprsnDrSad4eancenuectt,,nit.rmsocfsnbstatuesanlsmtlaooar4ofuoatcNuaaA.uitoldattsittdNltdetmhsdlfateen/esanoheboscohlinyrt--ewrpape1ln)sciTomiksaNmureDnausireecafaeldsayedepsh4sd,mdebfninmgcomsssPsrawnsreoTenemt-lal(detoaeeittvsttep,tyd.ahimaanstahnrsRttsshhorghontvcamvPhitiitcao,aitgeieboalidaegcorircemewyacnGredirmenoizskl,ttvtsogioamteunacirthhsrseeeluhcttitNneawfnoiaatmrdefdthamteogitaadte(nhedoohoiaeaortpbohsrahgodledMelfolmtpeaettefagynelllinpnocrrcsnfedaittaenhifsliaadnttgomniescenas.eghaesynoaedeeidiuTmntntretntitisus.cooytrntnlacvtnrtidvaseetmdaiatisDmeepoueoaitllnlaohctIBooitisatrtiatnnhasohcnsfardnnlirnfnr1nesiunaeocsnvlivaunp6topNddeoraacredag9un)ptiolUrdndir,ac--eteCibetzirehlonon9fnhiebsahemorfTies(srctuaepeariTsn2lneecf.3dfdovotaiMiopagneecissutmsmttoritoPaiestFasoernoraaplyfnaoeaoioliibdtvHbhNn.alrmsuiolresfiaxr1ratfhnanseelnyng,mepscorseeiiitp,sefnnpjibykasTeratscioaaerisohrnofcoitamthctabarefafnsaoelearoblunhnioPnircdsalniofroaoadnilsoabtgeysdfbtilnneeeatuleteiepitrtrottlfcooydtolfoasyzsotncceseciiloitBtdsveoetTescl--toofnfchqffga)tetcoelniaoesoeepce.oweeorhroeotmonntyiuerofiloesd-laerrvvrrianvnlieaeoIlionnem,fdaSiemconfaooncmsnnaptefriattsrfcpcPolatethhttbtlcnoootdvvtlutfteineetchpiiiheoaattirttduaaaltoeerhnotxfeooxetnhhleascereyirliatatoololnicecreatsirritltltininnnoideyddgcceecasss-ttltf.f 214 C. JELLEFF CARR 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REFERENCE RoCtoh.m, Bano,stKon. .J. (1986). Modern Epidemiology, p. 17. Little, Brown &