Document Loy1zZ7mwrvNpLxNqxBNyvNQd
Monsanto
rnoM iNMt ft t c.v.h.
iii, b, Papageorge______
OMl U0JIC1 K|t tMl Nil
February 10, 197b AROCLOR 1260 - HEW STUDIES
TO : <M: 'S'.' Bergen - B2SIf
B2SK
D. R. Bishop - C2SA 0. L. Bratsch - B3NA K. W. Easley - 1920 F. J. Fitzgerald - B3SA T. L. Oossage - B2SL G. J. Levlnskas - A2SC C. Pa ton - B2SC W. R. Richard - T3A
G. Roush - A2SA E, Tillman - A2SA
W. W. Withers - B2SA P. L. Wright - A2SC
The following met on Thursday, February 6 to review the results of a rat feeding study recently completed by Dr. Renate Kimbrough, Center for Disease Control, HEW:
T. L. Oossage G. J. Levlnskas
W. B. Papageorge C. Pa ton
W. R. Richard G. Roush
E. Tillman W. W. Withers P. L. Wright
Oeorge Levlnskas summarized a meeting held at the National Cancer Institute, Washington, D. C. on January 31, at which sections of liver tissue from Dr. Kimbrough's study were reviewed. Discussion relating to Interpretation, significance and required action followed. The following conclusions
were drawn:
1. Cancerous liver cells were observed in approximately 8$
of the rats exposed to Aroclor 1260 in Dr. Kimbrough's study.
2. This effect was not observed in similar studies conducted for Monsanto Company by Industrial Bio-Test Laboratories.
3. This difference in observed effects could be due to the difference in rat strains used in the two studies.
1|, Dr. Kimbrough will in all probability present and/or publish
her findings as soon as she can.
'
5. NIOSH has Dr. Kimbrough's data and certainly, following publication of this information and in the absence of any contradicting reports, the regulatory agencies will be pressured into reviewing their policies and regulations relating to polychlorinated biphenyls. As in the paBt there will very likely be limited attempts made to distinguish between types of commercial mixtures of polychlorinated biphenyls. The cancer cell formation observed in Dr. Kimbrough's study with Aroclor 1260 under conditions unique to that test will in all probability be quickly and without sclenflflc basis assumed to occur with all polychlorinated
biphenyls.
HONS 028816
IN . 10 KIV, 1/71
Ihe following action plan was developed and Is recommended for adoption:
Action
Responslb111tv
Dates Start Complete
Estimated Cost
/l. Publish the results of the Monsanto studies conducted by Industrial Bio-Test Laboratories.
G. Roush J.P. Stapleton
Immediately July 1, 1975
J 2. Obtain services of
cancer specialist to review both studies and interpret significance to
current PCB applications.
G. Roush _
Immediately
April 1, 1975 $2000 - $5000
i/ 3. Obtain National Cancer
G. Roush
Institute interpretation.
Following 2 above.
/ 4. Discuss with NIOSH, OSHA, FDA, EPA.
7 5. Discuss with key customers
^ 6. Complete WGK plant employee exposure s tudy.
oz
0 OIVD
Conduct study of Aroclor 1260 with rats to determine effect at 24 months when
exposure is withdrawn at IS months.
G. Roush K.W. Easley VT.B. Papageorge
G. Roush T.L. Gossage W.B. Papageorge
G. Roush
G. Roush
Imnedlately following 2 and 3 above.
Coincident with 4 above.
Immediately
April 1, 1975
Immediately
March, 1977
$ 70,000-
8. Conduct study of Aroclor
J 1260 with second species
(hamster?) to establish
if species differences exist.
G. Roush
Immediately
$ 70,000
MONS 0 2 8 8 1 8
-3-
Actlon
Respons lb111ty
j/ 9- Conduct 2-year rat feeding study with Aroclor 1016.
G. Roush
/ 10. Review rat liver sections from Monsanto A-1242 study.
G. Roush
Dates
Start
Complete
Immediately
Estimated Cost $ 85,000
$2000 - $5000
A possibility does exist that Dr. Kimbrough may be
Interested in conducting some of the animal feeding studies listed in the action plan. Medical Department representa tives will explore this possibility.
k"' &
W, B. Papageorge
tJ|_y
/pw
HONS 028819