Document LoakVo35ygQao5q51LeZJG7Qw
.. .... Now mmffiololha I UA Jo gabeiii
Mae"
em
. . . ... Hio~u.. Mwffod~
N gm Wo
3ab Of t
'Vmenmar'
-z- As . Ms axid mbea6i
W4
bifttc;a Axil 8rwk
petit. ... .
wilge i~- ow ri W", ato '5pla vow
co mts Us'
Cm" 1) H vins
JA
Or . It.st.
~019r7. t~~'Wvx 40 (4)
lue" OQR~0iin4v
lime21 A-sammu
aWrype nuuo"t mftsili4olrA 4i~4
ths ~A
'.
terx~L~Vk
.U~d.fo
Weft
nq*
d..by
CWO#,
Clb v
WD. tW
bf
cl ..5
f
d4d'o Pre ~i
27 ]in ACM
K"ords;~Mcg~ ilia
I
sos
.. .
'.
yaw' : Garrin, ~y~!Wh, Srown.
PetieAis exawincdin 13cfor industrial dis- eusroea~o4oG1 cn4 sxnMYrixriarr
:
ablana3c H2nCfit oc.od dypeal, those where such zings were examided mACCOSCOpianllY ~d
acwdciratgdn~oasfitsu-hdaedatbhe,esntdcotnhsoisdeerceodnfiihrlmiefed
or at
dis-, ~lac-
:ihrcc6lockawetera&en,o loththszurtiqtscapd the'unuivolvcd lung. His2otOgieal Expmperion
ropsp.
N~us performed by ouof,tha~suelz+5t5 .(8C)
withoctt Anatrledgt pf the:uctUpationalt~ismry
tehnn.anlga glendulsr i~tteia was eviri~ny
tzgmarnxyon and easirt .scauong , wus: Sup-
'. '. .. -.
occoPA120~TAZFatTpAy,.
Qctmpa4ottal histocies.was obtained : from mviti~lesou3eea,~PVseceaclaisnbadbeet~matle
for'betieAt, ri deFailid cuiRlpyment history was alaila6le..`Wheee no claim had been made, occuVSilosial dCWil we re obtained' from. wid~rhbsprzalcase aates3ndeoroues ' repaiu CrO+M ~tqtusts " In e"ac, .such can the :awai[gble employment his[otK gees exasiiqC"ci 6y qc-
Pcncuccd accuPatiopglzespirsmty ~ihysicians~ and further tieta~s tt8srding esch :and uGy
emplmymieitc WhiChknight haae Stiwilezf canxaa
~k aabtisWS were obtained. Thaac employmme.: iavolving contact widt asbestos i4..
thesi5lt~tieauragionhati{bren.pte~ioustydecu-,
; '
.
plemeptedbg~iaSCaBeperfodl~ .laculSrbilFaud
~~r'~attbulcau~e~ia.4taarutbtsWigswi7ircekshy"suEuudionti*dasiemamnvnauaa-l ~Top~I~d~qTsJ,~fyy'AsbfeosrtocspXkCoidniaecsmbr(yhorhcirc'unsstuiiNtgteend.,
yH6tions of the conttaSaceral Its~Y$, 3D(im `,`hack,
Wits=wesr~e~Id~osd~iunrttxhe6niterteti~alsix'asbtsye,ntA,gboscsctsossibqoad;a-l,
.~b~'er~st~no'~s~sis
casily .found, or numerous and aswas ciiagn05ed only when inigtsiitial was zccompanied . bY numeTRUS us-
bsYOB bndieerra furs eases where-the '.hisso-
~bg~eslfinduf~5, W 'ii doul~d~il the eliriital and
radiological faturds ware zp~tsideied caatiilly
. b.efore inWusiuo in The sGrics .
meted bys the MBC overa p 'ad ' 30 ycaH-
bythCCOIIet10R0'FIYSUIf8~Of77pCL4d?CaSF1PSt08
examinations inasbestos manut'attilrjpB and
other iri$tiBllieB add by CIaIfIlb for 9sbesto5
related diseases. TI1L5C~CGCOCES N'CIG C40 .411IIefL
where no history of asledtos exposure was 6[r tamed. Lt addition, zmplopment records were seatehe8. . :4ceuosdons! derails were Yeti&d by local government officeea who copfumed conmcc with asbestos from previous employers, work mates,aad .cetauKCS.byohcainigwsinem
ANAIYS50P-:DATA
erencesiC. pi'opoctiau.wt
,e%SR7iI10dby~~(~tCS[9011dd1~EC
c%adnmCd I)}'71d~181iCtI LN0.9
tests. AU celciilatioeu were p
Dell PC and- the IQG35 statistical. sottwese
plova'n' Rqult4 aiC reported ss mean' (SD)
and survival data FS medians fees . SiauiRCance levels
w. iwtahreratetraq&ueanrE.ialet
co0ffift12706 that LhC"Person had worked in 'P~QA$ "
theielevsnibmptoymcne>mdthedaiesofsuch '
emptoymehf.
1
Cases were categorised info four groups on the bests of occupationsl history and tusmlogis~l 6c~:8. in~s: (L) dccfuiitc(q-cxposci3, (2) probably sxposcd, (3)pon-oceupa4onally exposed, and (4) no}rexposed. Thus, a case where few occupational damns wer6available but asbesFOa bodies wee easily seauun hi~rcologicAl Csvpfr+aaon of'.rtecmpsy msFer3e1 wsx
4s e36esws "eupnsed . l~hege no asbpsTOS bodies were seen but tie decedent .had worked is an occupations where nstiestvs exposuie Was 13kety;, the case was classified as probably asbestos ~zpo$ed. Probable .exposurc was alsarecorded wen'~e decedent hnfl wetked,in-a less likely but iecognisedui3yvtry
Results
AGE SEX n[sr :e[r~zokr, axn s~io1FlNG HtiaIA's ~ro a total o 263 caxtsxe;Cerrcd, 272 (252 ~~ W~~ accepted as 6eiag ma7ignat~tmesu " ~lioma . The mean (SD,) age at death was
65 .2 (9 .S) years, canl;s+g f[pm 39 to 42 years
(180) ~y~e'ars")~.'andow~ofmfeernen(c6e6.b(9cn.6v)ecyen8tms)e-.n (65
Thee mediefi Survival from nine of symptom
Onset was 14 (12 .5) cnqnths {eugt t}9l
lontlts) With survival 4 women not sig-
~Patie1n't~s ~qdyiutVfYieudonltefsrsamthtahnat
of the raen. most bins mouths and
s~'^val6eyond4Qmonttts :wesvs~rare(4k) .
:S"j`'~vel was eignifleanllq shorter in peritoueai
wsrh nour vqry few aabcscvs hadies;geeu. Non,occupadonal exposure msluded arkisrory blF ".
C][j3o9Uce9uo((GT]7G Wl)taplace . .Y`JoO-e%poBGIiG '
WAS only accepted where no asbestoe ;lwdies was aeenaand the complete ocouqsuanal hisiory indicaced Nat euposure co us6estos wan udlikrl .1Taese cznmatrsulmd in erase being more 1q ro be tlassificd as asCescos .expoaed theu ailitiWl9e.
100
~~
yam ' ,
--
i f.,. '
-
7 ~
'
hu(i(s~wne ntunJxlinma iii soudeCPiX'Fipplnpd,
:idCUiifiCd:' . . . .
OF .SA7bfOSIR .'
.
Y
9 awVO';
z M1XAd -.
p .OA '. n Q 0. 3
0,1
Fyywn 3 m~1;won mwival'r!
WASme eases I t357;s :(P<0:0 . cases (I z3psyyo
Etas :rttiv'fri eVtloPl 2d7 as able in ; insu9'ic
There 81 ep5i histolqj a mu 981'C0[11 evident ponent cases .v
tea':
aasesr; (P<0 .
fB71gR~' 90iCD711
(14) in Whea7 quens)
was :see
XNlypI CWSV fty 'Ii~aR[IIt fYEly~/HS Of
moJ~ddion,c Cn-x50}., p<O.OiJm nvV~nn ~eeniwcnmarau7aworn..tidryper.
POb'S7TE
fev18~Ef om- [1 ~ILS ii d2 As 1
. . .,asbeam
."y
inm ex
..v..g~~. . )7b,' and 1::' FtBht[C3
diagnosis ~~ ee~F :death t:o 37 tlcaulcF eudubUP : . pugumnauiloc he I .rieeropfly . . : . posit on i'Evstirdes , if'sources posuzO .bY .
.
. . .z
~39%1 . sliest pam inidaUy~unaccompanied by in 87% of cases~ of which 96% Were oo-
MaGRi~en ;nrrsmh+GoUm :in.:aqmIFkaFl~ligihtul
. . ' .iii
.: . .,. .
.. : .
.: .
. .......
pupstiif%1z1 m brlgin . 'Yhi[ is Simdarii prNiRUS was lFased on necropsy? YasC9; 9ffdtde~3 wide, Z'
Sd1d1C8,~~~}n7Ei6~1~fCLjtoC!}~CCt94IIl4HN~C9NpA :9atlTplitlgOfLheLllMO11GIt"Wi~SfIiigIfle-0QuBt " '
., etSource 9B"BhiaT6ly~tt4WWCOC4Rp0,atlft "il7W 0fCk1tTOFIFC of 0 'fti9SOloSjGtlqf7Ex8rtd 1~f81
realu9c MA grcaeer-)ikelihnod oEneecopgy and ons~acts,ushorteningdC4n~aa{ Wth asr
.'kP7IRS0O6d.to1tfB1614Dtj0.ITA~ela1l0flTpiiC,BB~ll1`1(i~~7lyaW8~dq'p~O~Yq[~1vAiFal7iagl~1C1p1EnEtS
ComaCOUefl11'.iypeT~9-AU11RYAldt~y`robot~as Rb$GT7Bt~ between , IIiYC~' :dY4fE epitjlCTiHI Ge~~
nepn~ed iiithe snap buttLmy~ indusrip is t7lplcal tyycs, aat teas cl;ese a ~tt'eruice'in measuclc
eIP~ xUMe undar'COnddc~4~RF ofpaorhY- 'PafPnnal 6eriveen types
' g7ene, byt m~a nett8bte~ihat 37~1o nfpur asses- . : ~C sGecc`-psiticu12r1y.iRteteaiCZl io examine
'
.:
WETe ceTpGtY~ets~ L1CGV'iN0ri5xRstaM~1 War 16, n6t1-4ccujaLYlun813Y .~YCd~mCSAtlieIiQa;~aB bG
O[ WOfkel& in t~C pOi38fzukt~4,~A .or. : h1'pB~ 7i7-, . : CAT17bC [hEaCIfaVt bCCtl'YCpIfIiFS1YR1K~t~dtffPt. du:txtes iy..haxc expbkute precaufEO.,ds mad aqG cn[ aqMval ids previous stp,4io's":9 C'rke. sta Sox '
F~Ye been upumat~ A .f-t ind~ i~ anapidori -Ctsss~eadonas non exnased~dina.swilywerc .'Of99I7c6LOBC,Np091~[Cm7idaC8YC~TOG'~FgLItlCl81, 7i~OCCY1$(CLt1;pI~fOTEeS~p~'QXgOS,5rCt0H8~lEFtoB , .. . .
US[Ot1f.UtfICSCFufC SO of:
Illl[7AC[BPCt" Fnd .Ti1C L1ffrIC77.T 6GG-Iallb j] ~r3 ~~ jCLfIB 6 .
fdri .tbG Appropriate 'dcognosie : of' ataLenane ~canffiin Thar :rhess .were ProbaulY S?mtinet3
-
mesotiweliamS ' "- . .
..n* DocuP4ional in atigin Cssee"were, on. .
Nfsligrant mesnGlYeliofna is uslsally a dideasa, avccaaaj sl3gli~lYYqnngect}aan,rHa wlwk .~exDUPa
,oflaxcraidtll~ p.ee'and the mean ago seen m a,m~lar w athe* stucUes,' out nor sigqrisik~',cawLy
- our acres:: (G5 years) i's'somewhet"ugher t4sn . :."sa.lklihou$E.spraepmviouaxeportsluveshowa
m euAW 'senes.' Tftis :could 2C$set an lm-, :a alsortu sutvivgl wi[bnon-iibestos-teI9ted
proeetneeii m adsz'i~vyfs, but the &c9urnc3' neHt msothelioma .' Qur stu+i~' did roc
'.
dasrtibu,+ionforage deawnstraces a wadciengc cocfrYm
of
aBz,tsfonset :(Pat3eius in r5& 31)s ln c me.." latexifq wavapproxiMatia y 40
y9.e4arss),. .
.
.
.
.
Side nor .
of
d1is . a
5rmi1arl~y t. e e
nn ;diff~nmM111 ~Chavylo)u
siee or. 'Ilms
agam Comparable.to otI*.r.q)or% ftwf litithcy period pte-xse-ytiars:
0 Was the ; onq was
d' Crentia g ArMF. As V 11
r;9 vo oun tQ gepr. .
Unpr Mcasc:Ko
nigsothchoma is ~czsft:of 0 e
hOViem. 5b0": mode prewons Stu d me high, propim4on or pjetu"~I meSQ--% imilar toethaT ofmost 13K .Sen'M
'd mitcftnendACAItLh. aau
4,
an ne
Ae
odes
do:6ff
. ..... enTIOn a~d
Although t.hc sopac %aphort
aadiet; : muWbyeq~.ifrdiO)IC6 U. MenusiIvn .
08Mi:t1, M~ =UoWno: rof
-t.. .
e .A t eel a-
~o
he inteficistihs, dirt was the
prier
a. ih
a.
E: c ratio of 1A-1 ; prMovis rct~. 6 and
h~i beg* rjqO4, :I doso'bid in ~ one
sWcrtieas~VT1W0S%poa d
a a i ~d
grAipbs foir inVft tion of er d sCs I'm
oi~miai to thai pitle 5 w&AAO er xhad in
.-pMrumbrI9s
m1gs &om Gcmazxy,17 b'At ~Inall we have limite;d e oettain S66
IOcodlf~iutkft"dmP.toAoAtowdlneusrn,cgrsiuiPcnoetss&hseii.bwpvrlfeia:b.e.f". xrpopldaleenenpgmcobieDolsitt. tliiosntounIrc~fobWieuptmllwdoi.stoieirnnca%
'the &OUP 6 a whole, gftd Is amoill ~-Neujjd
:ipafitnj6mauagigtoy upnrgm.ej.1fitgd~xeoi4tjh~eravid~imtoanicoinoetohr.clocat
mi,y odcamonallyu ~.Oient f6r,UIVip a ftar~~
Wori
tipn%~ Tucst find-ing, ruse e.
:qPe9tion as to whether
for .
ainfaimaturep M our Study ollowedo'cRon-
mv
Wwgh.
Ask ft
.&grworup;%. J~.
lated. wraouri. iive
bMOMiing rearvro%. of
pot op%4ate trtatm.en
fted di, . .....
pain;. Y9 rqco~td;
... "but
d.i..d.
not
diffortnti4to
beroocm
~~Comahm, f sow,,
I
16ftuenadths *flTbote
;igks h .atid IR~ dikt
pa,d
put Uposwee ! S Commonly
1toI:p.
tae6caaetd. C~oAsg..
of: 04r cate,
ftbtcftij";b4iIb.rpIuMbIiht;d6
Spanfitrsye
tlkft
0 .
ftp~ . . ...
.
.
offen,% .%Wb,. Coripan Y. minor 0 cst j~.aid ox4i. W ~h-
toldwitti;slyhnlftagin Lid"1145
Suuot$ th9t~eedke~6ih*Wj7io..iiiouiaebt~~der~.:
evey Rog. arpia-iii g~iiod
in: Otif sway hpmvS~ 4cWiry.9A%Wv: in i: proppacon ofcuis.~9'95%) A 'histolojeW ; simplia w~ I accorpto
4-~ pj Hams; w19e
d'g` o1%;hdamd
i
Rat
LUMMIr an4 0 f not
M
zettaint stold$iu
6M
...
011.~~ CRSCN
IdchavIour;
.
I*,: C6Me40 tv
prew6ugIY, therg:
thiS 4hib C~qiil
%&, ve beft
IEMIXIZ, reports. TegRrff.ihg Aequedq~ .Oi ~iito-
ogiw. . . :. .ty'pe, SoM%e
i~foMoimiP6NHioredixtoemq$4i ~cryt,tsortcd ao diet
7--~M2.,odgo14do '41 ia ho
two
2
dzae
. .
Got
v
no IkOt hitia,ffoit.r. ~OL F'"AI.~i4o
Y6 a
98
q
..."
. .,
.. . .,
..
-