Document Lg5Knky3VLJmpkVZmyE1xeD45

February 16, 1943 Dr. H. 0. Schrenk, U. S. Bureau of Mines Experimental Station, 4800 Foirbes Street, Pittsburgh, Pennsylvania. Dear Dr. Schrenk: In response to your letter of February 5, I a m sending you herewith a list of subjects and speakers which we offer for the program of the meeting in Rochester. I am entirely willing|to leave it to the program committee as to which of these papers will be most acceptable. If you are short of program material, we could give all of them, although, of course,you will not want two papers from the same authors. (I refeir here to the two offerings by Deichmann and his a ssociates.) Just a njord of comment on these several papers for your benefit jin making such selections as m a y suit your program. The paper offered by Treon on the group of cyclic compounds represents for all practical purposes the completed results of a rather comprehensive study of these materials. You know quite as well as I and perhaps a great deal better, the practical importance of this subject at the present t i m e . The paper offered b y Largent on the fluorides is more or less 3elf explanatory, but it represents a n estimation of the fluoridejexposure in magnesium founding based on urinary excretion of fluoride. The paper on pentachlorophenol, if chosen, will represent a discussion of the toxicity and mode of action of pentachloro phenol together with some reference to its fate in the animal organism and will be a general summary of our observations on this compound and its sodium salt. The detoxification of organic conroounds is the result of a study, b y no means comprehensive. of certain mechanisms, par ticularly the conjugation of toxic compounds and radicals with glucuronic acid or with sulphate. i The paper which I am offerlnghas to do with balance studies on a huma n subject, in a n effort to determine the degree of absorptlo a from the alimentary tract of three different aluminum compo unds. Clinical observations on the subject have been 7 o7 Dr. H. ft. Schrenk - (2) - February 16, 19^3 carried on along with the metabolic observations. I have chosen this subject rather than an extension of the vork on the metabolism of lead, partly because the data on lead can not be Worked up In time, and partly because I do not vant to confine myself entirely to the subject of the lead meta bolism | I a m very glad that the meeting Is to be held and I heartily approve of the arrangements for combining the three meetings. I can ill afford to be avay for four days, tout the character of these meetings In the past has been such that I can ill afford to miss them. Therefore, I shall probably make it a point to be there the entire ti m e . With kindest personal regards, Sincerely yours, RAK ef Enc. Robert A. ehoe, M. >. Papers submitted for consideration Ffrom Trie Ketiering Laboratory of Applied Physiology ! Program Connaittee - A 1 .H .A . - May 1943 An Experimental Ptudy on the Ingestion of Aluminum Compounds by Robert A. Kehoe, Jacob Cholak, and Donald Hubbard The Physiological Response of Animals to Cyclohexane, Methyl- cyclohbxane and Certain Derivatives of these Compounds . II Inhalation * I by Joseph F. Treon, William E. Crutchfield and Karl ; V. Kitzmiller Exposure to Fluorides in Magnesium Founding and Its Significance I by Edvard J. Largent (1) TheToxicity and Behavior of Pentacklorophenol in the Animal Organism ' by William Deichmann and Girard Thomas (2) The detoxification of Organic Compounds by Conjugation vith Sulfuric and Glucuronic Acids I by William Deichmann n 3 5 r\ o w \j w /