Document LKeYy4vmbg0pD2y0QX6N5mjk5

AR226-2823 Copies to E, X. du Pont de Nemours and Company Haskell Laboratory for Toxicology and Industrial Medicine Materials Tested: Materials Submitted by: HASKELL LABORATORY REPORT NO. 142-65 Haskell Nos. Fabrics & Finishes Department Marshall Laboratory OB SKIN TESTS m HOMAN SUBJECTS Other Codes: 4261 4262 Test Fabric: 8enC through the regular cycle of an automatic washer, "Tide" and "Chlorox" w e r ^ u s e ^ i t ^ h e wash w a t e r a n a 4 oz. of the proposed fabric softener were added to the final rinse water, thus providing a concentration four times that recommended for ordinary use. Procedurer One-inch squares of the treated and control fabrics were placed on the arms of 79 men and on the arms or legs of 125 women and held in close contact with the skin for six days. Following a two-week rest period, patches of the material were again applied and removed 48 hours later. The skin under the patches was examined two and six days after the Initial application and two days after the final application. Results: Reactions were not observed at any time. .Conclusions: treated with four times the recommended use concentration o f i _ iTPbot cause primary skin irtitation or sensitization in the 204 persons tested. The commercial use ot this tener would not be expected to create a contact dermatitis problem. DBH:clm Date : September 23. 1965 Report by: Approved by: cotP**