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aM 4. Mortality Among Employees oaf Perfluorooctanoic Acid Production Plant
"This published paper (Gilliland and Mandel; J Occup Med 1993:950-954)i the second updateof the original retrospective cohort mortality study (see studies# 2 and #3). This mortality analysis is the second-hofatlhfe doctoral dissertation by Gilliland (see study # 5). The cohort consisted of 1339 male and 24s female workers employed between 1947 and 1983 in the chemical division ofthe 3M Cottage Grove (Minnesota) manufacturing site. Also analyzedfor their mortality experience were 1449 male and 504 female employees who worked in the non-chemical division at this site. Vital status was ascertained through 1989. There were no significantly increased cause-specific standardized mortality ratios for cither men or women. Ten yearsofemployment (or more)i the chemical division was associated with a 3.3 fod increase (95% C1 1.010.6) in prostate cancer mortality compared to the non-chemical division. Gilliland and Mandel suggested the results be interpreted cautiously due to the fact that there were only four prostate cancer deaths in the chemical division cohort. Based on a subsequent review of work history records, only oneofthe four employees in the Chemical Division who died from prostate cancer appeared to have worked directly in the PFOA production building (Olsen etal JOEM 1998:40:614-622). This points out another limitationofthis study in that the entire work history records were not abstracted during the original study (see study #2). This abstractionofwork history records was recently completed. An ongoing retrospective cohort mortality study will utilize this information to develop a
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`more refined exposure matrix for PFOA. Vital status will be updated through 1997. A final report is scheduled for September 2000.
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950
Gilliland & Mande! - Mortality in a PFOA Production Plant 1
Mortality Among Employees of a Perfluorooctanoic Acid Production
Frank D. Gilliland, MD, PhD
ma LATEnRd)fs Jack S. Mandel, PhD, MPH rpoly aed ware, AAS FEA N oae ayaate uste aBvee parPtesrfpleurorboiollcitoann)oiicn saecriado(fPtFhOeA)genhearsablepeonpfuoluatnidonatanldowatlehvielgshe(r10le1v0els10i0n
erfluorooctanoic acid (PFOA) and its. are' perfluorinated surfactants, Be.
cnounmsbuemreorfipndruosdturcieal ianpcplluidciantgionplsaastnid-
TihnehcuootmoaernmocfiarohnoenddPesoEOdixpedps3a7ot3h8resmralTmehthedeerm4s5smoaednnhnecobsnranb ppr iepmnppihey n tt was D onSeCtTr ErdesDe neEreeinnE,gs23a0 `between PFOA and mortality using a retrospective cohort mortality design, PFOA induced marked hepatomeg-
ray ot kero 1947and 1983 at a plant thatproduced PFOA. The all-causes `standardized
mortality ratio was .75 (95% confidenceinterval[Cl]. .56 10.99) for women
rodent liver*s The chemically diVerse group of xenobiotics that
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Palocarcinogenesis.\* PFOA did not
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