Document LKX0eJMg999xk95LZZObn9vZX

PECs and PIC I ; SeotchGand ARAR6.- ISOC p bt4 7 3 \ 44 COTCHGAR Toxic to animals & people. Persistent forever. Pervasive in 1human blood. 3 by BLANVIASTER, NS PFCs ei 03170 Environmental Working Group || PFCs and PFOA: A troubled classof chemicals used in ScotchGard, St... Page 1 of2 PFCs GLOBAL CONTAMINANTS STAINMASTER TT Report home wo IEE2:.In People Everywhere -- i - Ea ------ 8: Moniek fans Ki Finds So ECB - Introduction `Consumers instantly ts rates igfo topo nacnd pair, y50s recognize them as household miracles of modern chemistry, En veto fom Bresso compas comets But in the past be re five years, the multi-billion dollar "perfluorochemical" (PFC) tas Shaocago none 3 ft a ih oo esa om A flood of disturbing scientific findings since the late 1990s has abruptly elevated ema ecu wi ar cr nk chemicals, the most pervasive and toxic members of the PFC family never co ort frat ane mares is amyoffhe ret `stopped manufacture ofa related perfluoro ty sit chenmical, called osPFOA, upon, that is now TAStive 14D. ot ch _ SRGSSNS `Shoppers Guide to PFCs ees rove th st, comprehensive review us published of the more than 90 percent of the U.S. population, EPA is expected to announce initial eps 9 Rorll (2003), i Tid rg to cin howejracomSpaerkrese4naEoLSont, wh ee se orrates sesame ho te hae hihi 000314 Environmental Working Group || PFCs and PFOA: A troubled classofchemicals used in ScotchGard, St.. Page 2of2 Eb Ribot ws e infogeng.org scr bong Scotchoards 000315 Environmental Working Group || PFCs and PFOA: A troubled class of chemicals used in ScotehGard, St... Page 1 of2 LEE I A WEARS Gr PFCs GLOBAL CONTAMINANTS T Reponome ~~ ---------------------------------- _ Poa Eve_care reek fen eoTrtyJ A-- EJPopnts S-- ain Abo-- ut B-50 -- week F:os Eds _ B I ASR SL EE mn a_ n% T --_-- eases ues Seare chable database: e PEC documents E-- E-- Ea SCaTrpAetINMASTER Part 1: PFOA and other PFCs come from common products in every home Nfooondstciocntkaipnaenrss, cfuamiatlurceo,ntcaoisnmePtFiCcss,, mhoaunsyehooflWdhiclcehanberresa,kcldootwhinngI,haonPdFpOaAckInagtehde eStnaivnmiasrteor,noSmcaietncnthhtgearhdu,mSaInvebroSdtyo.neT,heanbdraonthdernsa. mPeFsCasrearwalalskonouswend: ITnef3lovna,st array of Industral products and processes. TmeafnluofnacatnurdePTFeOflAo:n Taenfdloins Rreeliefassedntot PthFeOAir(,CBa)l,onbgutwiPtFhOoAthIesruPsFeCds,to WPhFeOnA Tief1l5o0n caomoiltoweadrdtoisifheaantdedwatoterrolaltiTnegftloenmpmearnautfuarcetsur[iEnxgtrpacatn]ts OfaetnphdeeltrSeocllo,ommgermreoaasnlec,coahoonnldssu)w:amteePrrF,OpAIrno3cd/lu5u0dcitcnsogmaceansrdpfePrtFoamOnAdpr(fofudnluiucttousrrodepeosliygnmeedrsto poraaoionrttmsweaanxnt,ds,wchlfeeoaronedinPwgrFapsprso,rdeuscpturssaey-dsafn0o5dr sfluerraoftamhcetprar,notsdshu,octtTssheiaskneed sPohRtCahemprprcooldooutcahtisnng,d. IPnacpleurdeprfootremcutliaont,ioannsdlkoercStmaaidnemawsittehrcfhaebmriiccaplrsottehcattiobnreaankd dZoownynlinto (PEFxOtAracatnd| FruelaltDaodccuhmeemnitc)als n the environment and inside the body. aInnddus3t1rihaalveponloltutbieoennarnedauPirFeOdAb:yCahewmitcoamlonciotmopranoirerseploirkte eDmuiPsosnitons cofhePmFiOcAa,lsPaFrOeScoormpoltehteerlyPFuCnsre(gtuolaait,edw--astoeralloremliasnsidosnsbaerceauesgealt.he eifnsrdtouimsmtamrtayensuosftfaucdptioeulsrliusntugibomnpilltaontatedsdi,ntngoso,2bf4urtopmroo"nvGyiodwfeonrtshrteerceceoanmmtp"yaiennaidreussst'arnipaadlrtouinaslleyrs. aFrnoumatlhesaes adiorcaunmdenwtastewrepolkantoiwonthaftrotmonsDuopfoPntFOaAndha3vHe pbleaenntsrienleWaessetd Vciortghiinnag,, NaonrdthpaCpaerorlIinndau,stMriinensesinotGaeoarncdlaA,loabratmha;Caaronldinfgr,omancdaroptehte.r pGlFacBeFs.OATnInt1o99th9eoaliarna,ndDutPhoenOthiroelReiavseerdforvoemr 4it0s Wtaonsshi(n8g6t,o5n06Woprokunsds) TReafvlionngprreodduuccetdionthfoasceiltoyadininWgesstt V1i0rgtinoinas. (T2h0e,1c6o5mppoaunnydsn)owinb2o0s0s2t.s of 33H'sbefOorriegitnhaelySecaort2c0h0g1arbdreaankddoPwFnOAn:toScPoFtOcAh,gaarmdopnrgodoutchtesrmade by cEhnevmiircoanlmse,ntinalthPeroetnevcitiroonnmAegnetnc(yExftorraccte|d 3FuMlltoDoactuemrentts).ScoTthcehgard afonrdmupleartsiiosntebntecian utshee cehnevmiircoanlmseinnttahnedptrohdeuhctumwaenrebofdoyu.ndThtoe bpeubtloixcic: risecuosridngcoPnFtSai,ns3 tsiiseterincfhoermmiactailontoonPOthSe,nae6w aScroetpclhagcaermdenftortamaPlF,OS3M bbraesaekd dcohwenm.isItfry3fHorsroempleacpermoednutctcshe(m3i1stWreybsisicb)as.ePdOoSn tdeooemsenrot 2iconol, I key breaks down into PFOA 0% wel Other PECs: PFOA s only one of many terminal breakdown 000316 Environmental Working Group [| PFCs and PFOA: A troubled classofchemicals used in ScotchGard, St... Page 2 of2 c15omPpFoCusnkdnsoowfnhotouspeohlolultdephruodmuacntsbltohoadt.coSnotmaienoPtEhCesr,pearnsdisotnelnytone of choummpaonunbldosodthIantclcuodmeePFfOrAo'msccohnesmuimcaelr spirsotdeurcst"stahnadt aarree cfhoaurnadctIenrized bchyaicna.rbAonnotchhearingrloenugpthosf PeiFtChserfoluonngderinocrosnhsourmteerrtphraonduPcFtOsA'bsre8a-kcsarbon dfoorwmnedintthoePEbaOsSi-siokfe3c'hesmiocraglisn,althSecoptecrhfgluaorrdinfaotremdulsautlifoonn.ates that Next Page: PECs are in peopleeveryihere i info@ena ora 000317 Environmental Working Group || PFCs and PFOA: A troubled classof chemicals used in ScotchGard, St.. Page 1 of7 SIRS SE THEE A YAGI PFCs GLOBAL CONTAMINANTS ~~ mmm e "ontimer PratR uts BPE 3 So ECs beo at Forever - FC -eatin Canserns 527 : n Ver, Food BAT 523 in Annas Virdee tsPaonntsss SpSpimn Aboutasa2n6i0eon nsick Pans il Birds e r Se TE Ts "a9 vi renseaman -------------- act tonof PEC Pot-- ion -- Sefa m Sen Ere TTT Searchable datanase: PT EC documT ents ASBh Part 2: PFOA is a pervasive pollutant in human blood, as are other PFCs GPDouFpPOioAanttai,nodn3.MotHahonewrdaponetrhdfeurwahPryFoCcthhmeeamynicuiafglansocrtceuodrnettahsemwhiaandartmaeimntpghleesbiiginnodsaidIcsaootftinohenseofdgeehcnaeedrmeaoslrUae.gS.o. that Gistrubing chapters In the unfolding tragedyofPFC pollution. I2n00s1t,udsiceisentthiest3sMreCpoormtpeadnfyinsdiunbgmiPtFtOedA tion tthhee bgloovoedronfme9n6t In re Cpolumebioar,f5E9xctrcahiceltdr| eFnnullteDstotcedumIenn2t3]s Althoauagnhdt tthhiseDre iesmtariics ntsotfhe DlaurPgoensttsftouudnydoPfFcOhAldirnanu'msbiblliocoadl,cotrwdabsionoodtftrhoemfrosnt.e bInab1y58a1nd WbpollaronoktdernfsroPmamornakietsroesrcbeuodrngdb,ybWaDebusyptobnVoitrr,gnitntiwoaa.fGeAammvaoleenbgwroisrhekvetoernsbapobtrieetgssnawTenifttlhobnith defects - one aDnocuumnecnotn]f.irTmhaetdseoymeeanyedatre,aDduuPconttderfeeacsts,iganneddo50 wnaonmoesetnrilfraonmdtahyeepdleafnectt [Ful hPBAueCmtswaennenbbllo1oo9od7da2fsarenoadmrlt1yh9e8995g,e1nne9or7a6ll,esapsobtpohuulatantthinoeinn.etiPsmtFeuOdPAiCewBsaSwsewrefrersetpubebanlntinasethdei.delIoynnsIltdeuevdeniltesnseofd in lvcooenasddumcastjaeomdrpilitneystohffercapomams5tp9li5exctyheeiaerredsn,firn2od3mu8stneryiodsiectiye0ntW0ia0ssthspihnaagpvteeondSettaehcteteeUdreyPsiFdiOeAntnsin,gtahned Spproximately 2000 blood bank donors. RScaiveenttiessttsedh.avIe ninodwusftoryu'nsd210501PFsCtsudiyn hofumsiaxnPFbCioSaIdn-heuvmearny PbiFoCadf,orswciheincthisttshefyound fleoFvuuerllastCwohecirugemheewnrittl]he.ivneRlteshceiennrcathnilgdaerboeorfnawtthohraaynthsIatnusaddiubelestesh.neimAgenhadtsecunhricedodrnecinner3snMhsoawwboiornukgtettrhhse-e h(eiEfgxfhetecrstatsct ftohuensde cahtesmmiciallrs emivgehlt Ihnacvheidornecnhialnddreand'uslhtse,albtuhtacnhdildderveenlompmaeyntb..e.at hiPgFhOeAr rwiasksto tHhieghienrclreevmeelnstsof) tafhfeerctsPFofCPwRitOh etoxwpiocsiutreesssismiimaplrytobetchaatusoef tPFhOaAi.bodies carry cnexocclredetISenothmraoefdhutochewed,bmePasFsstOoAopfpceiPdrFc,uOltAahteaecsbconudmytuhlweaotbueoldddyirnefooqrruigyraeeanrsosn.anaIdsftntiiemsawstueeedsxp4o.s4uuryeetsarstsiontPcoeFOA eRpxrmcoradeuntcestsPaaFpnOpdAeaehrnavstior(boeen5meerxneptloaeslveacdnocneftreatqomuihennuattmliyao,nn,pheterhahetahpfascttdhaahlnyat,httehhferaocbutogtdhhyactcoanPnsFuOsmlRoewarlpypears fo be continually reintroduced. 000318 Environmental Working Group | PFCs and PFOA: A troubled class of chemicals used in ScotchGard, St... Page 2of 7 Of every 20 children tested, CHIH HES HES HE [OS TE PIIN RIS TTVIIS S PIS e PAIN BES.reVIN PES. PIN|0 19 had blood contaminated with PFOA. ChEvoeemnemniofvniPrFcoOonAnmsewunemtreearnbdparnionndeuhcdutmsfaoinmlbudiseoeg,.riasodveceotrnocitemnhteerraatetirohmneincTeouu)oltdbirnceaoatnketdoinuCutoe,mtpHooObuGunUldlCdsH-iinn EeSqRhuRivpTrdheeeccuaarsdtoeersaPotCrawch.einctHhuurtimheisas,nroachnoesuinlodwrmhbaaetteixo15pnokwsnieoldwontcoacebuvoeu1rt5-.IGnneocorkeranadadiwnaghtnabrrmtaatucenstosoufof PoSroFoddOucavnoddueaccyihnfeeo.rxpexoasmeplTeo,uteesvednri8v5enpobysoanavnroenxmpoesnutraelsctoontFaOmiNnaotimon c(oonpsummaetrer fCFoiobfntdaeunecanltyePsdeFsbC,estiwhnecaeuvndein1bg9e:7e7nafnodu2n0d02i,n hcuemnatnsblhoaovde. oIunnndearaliy1250FsCtusditeasrgeted in + ESSitcgeihmtomncihsnegmhiafcvraeolmdsettihencetthoerdeiFgPiFOnOaSlSRSfeeaometiclahyna(datrhhaeefsoucrlhmfeumolincaaattleisso)nh,.amtost (SSFEoEB0pcSa)h,aarIsndcIltnuegdrirmneegdeMin3at7ts0e,stoi1n5tt5hh6e,tebFrrmReiOanSkaldAo,bwrnanecdshdFaFoOurSAo.pmroTdthuheceytahctaivvee PCGhEeaNniSnesasnrdeTTsHHpPBaFFcODiSSv,layCcoIuhestimenissadolfofrPuaRnOcSu8-wrciaahrlbaerne6l-caathenad tI1ok0Pe-cOFoGrO,sSo,annd {Ekceon Fo Document ScSHiecdvoeeh)onl,camhnoedmtaicctrayllaasteinmptahmeoePmrFOpTrAoadfulacmtiDslryIak(egtshSet,acaianmrdabsovxtayenlrimacenrd ZPCaEorLbnonRchacerhm,iicaanlledsnmgutshiesdcriaan1g0is0ntdgaprrasackmtaog&iSntgFo.A12Scch(ioecnrhtoeicmsetirsciahzlaevdreebffyeoruendd to SHE 7 Clo, Chl ana C13). xe | Fl Document] CEsoveniatdraecmnhicnieantgoifofnlbulboyoriodSdeMcIoCnhtEthemaImhCiuanmlaatwniaosbnoddiyon.nteOhren.ot1D9ob7ny0astl.hdeTEcaaorvlemyspwaoonfrytkhBetuotUdnbehyfeiGrnesetnhyutmosfan VoRaorrckhudepstomer3hiSsscabhmooplodeofoafpMpNeedssircoeidwnetoiaonbdoedGaerHdiiesantnaarneedpsoarmtseehdiavweesddurhtpoartih ssnyanpoemdfotefhnheuoride aSiednscontroversy 0 push ikng Water uppesfo purposesof dental MIonrorp1ie9nr7gu6aoOrr1o.nhcTtuaavmneaosniacbnlcdoodidsscaolmTleahbsoarauasttoharonsresteosnfptea3ct'uilvsealtpyeedtdfehunaottrinmfaudtleiadpnieoerogfantihceso-rgSaOniRc, rDBreeaFnsucoehrenodc.taorSrbposenacsfuaartpaeptdeeadorne(dahnbeoethspeorruersacerenotoufpintohfheusuem'amsnpebeoaTnudt,roamcnndDeohmoaidkc:os.omeThmeigahutthboers "These findings suggest tha the s widespread contamination of 000319 Environmental Working Group || PFCs and PFOA: A troubled classof chemicals used in ScotchGard, St... oEEl SE a TR Page 3 of7 Ft E En T TT EEE | iar ar05. rary [m[ mE[ fwi rm] [mee 000320 Environmental Working Group || PFCs and PFOA: A troubled class of chemicals used in ScotchGard, St... Page 4 of7 Ee | re Pha ied So ] 1092s. ete sen, | HOSTIORIEL I Yah M556 200010u2sb0o0a2te-om | PESTERTOR, hi C12, THPFOS, THPFDS 000321 Environmental Working Group || PFCs and PFOA: A troubled classofchemicals used in ScotchGard, St... Page 5 of7 Sbloomoed cathifladrrehnighhaevrelelveevleslstohfapnerinfiltiuaolrtoecshtesmhiacdalsshionwtnh.eiAr c1o9n9c8enptirlaottisotnudoyf PofFO1S2 icnhisledrraenofsh1o1w5edppab;mtahxeinmeuwmstudy puts tahmeamxaixmiummumofa1t0S01p5pbp.pbI.nI3n'tshe21090919ssttuuddyy,,PPFFHSSwwaassffoouunnddatat Cmhoirledrtehnaantstehveehnitgihmeesst ltehvieslsleovefle(x2pomsauxreimsuhmowofco7n1c2entprpabt)i.ons. up to 48 times those of an average child. Lpoepvuellastairoen.hiOgfhtehre isnixcPhFiClsdrfeonutnhdainn tihneabdluolotds sianmtphleesgeInne3rMasl 2ad0u0l2tss(tPudFyH,S,foPuFrOaSrAeAf,ouMn5d7a0t,haingdheMrSlSe6ve)l[sEiWnGchEixltdrraecntt|haEnWiGn FutlhalnDoIncuamdeulntts]..InLesvheolrst-otfePrmFHlSabaorreatnoortyabalnyimhailghsetrudIinesc,hiPlFdrHeSn ccealulssetso cceolmlumluarnidcaamtaegweitthotehaecthhyortoheird, ajnusdtdliiskreuPpFtsOSthaenadbilPiFtOyAof or chemicals that break down into PFOA. pOrneevaolfetnhteinpecrhfilludorreoncthhemaincaadlusi,tsM.S3S,foisunfdarthmios rcehemical in epevrecreynotnoef otfhethaedu5l9t8s tcehsitleddr.enMt5e5st6edi,s abnutIinntefremweedriattheanbrfeivaekdown pprrootdeuccttioonf, Sacsottchhegbaorddychceomnivecratlss tuhseedchienmfiacbarlics ainntdo cPaFrOpSe.t This lreevseullst opfoiSnctosttcohgtaherdpocsosmibpialirteydthtaotacdhuilltsd,repnearrheapesxpboesceadusteo ohfigher dmieftfaebroenltizbeehtahveisoercphaetmtiecrnasl,s Amlotreernastliovwellyy,thcahniladdruelntsc,ouwlhdich wmoetualbdollietaedstfoorchliolndgreern pbeeriinogdesxopfotsiemde.to perfluorinated tPhFaCns pmraeyviobueselyvesnuslpoencgteerd-i.ived in the human body `oTfhheo2w00l1oncgh-illidvreedn'tshebsleoocdhesmtiucdaylcsaamree Iwnhtehne 3hMumwaans baoldsoy.ba3cMk'tsreacsktiinmgatoens colfatihmes thahlef-alimfoeuonftPoFfOSthein cthheemihcuamlainn tbhoediry b(otdhieets)imheavitetaoksceisllhautemdabnesttwoeeenxcarbetoeuthoanfeof plaanndt neimnpelyoeyarese.s,InIaM 2s0ci0e2ntsitstusdyesbtaismeadteonthsatertuhme clehveemliscoaflsPFhOalSf-liinfeniinnepfeoorpmleeris34 8.7 years [Extract| Full Document], Ihnumthaenshaamlfe-ligfreooufp4.o4f fyoeramresrfeomrpPlFoOyAees,_. 3ThMeheasstmimoasttedrehceunmtalynehsatlfi-mlaifteedhasa. iDnoccruemaesnetd]a.s 3M has tracked workers more thoroughly [Extract | Full r`Oenleevpaenctultioarhietayltohf pceornfcleuronrsocthheamniciat lis fsortohtahtetrhechheamlifc-ailfse. inSctiheentbiosdtsy hiasvleesfsound nenovmireocnhmaennti.smThbiys wmheiachnsPFthOaAt aenvderyothPeFrOAtermmoilneaclulPeFCosn ctahne bpleabnertokiesnhedroewtno Isntatyh.e P`OFpOpoArtwuonuiltdiescofnotrihnuuemeavnesn(IafnIdtowtehreerbaanninmeadl.s) to be exposed continuously to Next Page: PFCs last forever. References 000322 Environmental Working Group | PFCs and PFOA: A troubled class of chemicals used in ScotchGard, St... Page 6 of7 DecEandveis.ronAmveainltaablleWoonrlkiinnegaGtroup (EWG). 2002. DuPont Hid Teflon Pollution For http://www. ewg.org/policymemo/20021113/20021213.php. DetBeurrmriisn,atJiM.on oLfunsdebreurmg,haJlK.f-Olilvseseno,f sGe.v,erSailmpfslouno,rocCheamnidcaMlasn:deIln,teJri(m20R0e2p)ort #2. `ESPtAudAyRS2p2o6n-s1or0:86.3M Company, Corporate Occupational Medicine Department, US c1a1r8b30Mo-.x3y72l40;i0c1B.bEaHTsQSe-Cd0A3f8Bl(1ue-o)0r3os9cuh4pep;mlieBcmEaeHlnsQt-a-0lD5on9co8kt0eit3ce7n3fu.omrbUse.uSrl.sfoESnPEaAHteQA--db1mai1sn8ei0ds-ta3rn7adt3i;veSEReHcQo-rd AR226-1019. repYroordku,ctRiGons(t2u00d2y)o.fOraamlm(ognaviaugme)petrwfol-ugoernoeorcattainoonat(eon(eAPlFitOt)er ipnerratgse.neRreaptoirotn) pNor.epTa-r6e8d89f.o6r.3,M,ReSvt.iePwaeudl,inMUNSbyEPAArgAuRs22R6e-s1e0a9r2c.h (Horsham, PA). Sponsors Study pla`sTmoave:s,prOeRv,alaGnucye, aWnSd achnadraBcrteeyr,izWaSt.ion1.9I7n6.BiOorcghaenmiicstfrlyuoirnovoclovmipnogucnadrsboInn-human fClhueomriinsetrbyonadts.thAe s17y0mtphosmeieutminsgpoofnstohreedAmbeyritcheanDiCvhiesimoincaolf FSloucioertiyn.e aCnhidcaBigool,ogIiLc.al `August 26, 1975ed. Washington DC, American Chemical Society. Vol.: 11-7 134. and3Mto.xi1c9o9l9o.gicPaelrfdlatuao.rooU.cSt.anEePSAulAfdomnianties:trcautrirveentRescuomrmdaArRy2o2f6-h0u5m4a8.n sera, health Mar3kMe.ts2f0o0r0.3MC:ha"rIltewsaRseiachc,omEpxleectuetisvuerpVriicseePtrheastidIet n[tPoFfOSS]pewcaiasltiyn Mtahteerbilaolod bank. supplies." The Washington Post, May 17, 2000. flu3oMro.ch2e0m0i0c.alLaabnoalryastiosryinchomupmoasnitseerrae.porUt.:S. aEnaPlAytAidcmailnriesptorrattsivoef RdeactoarfdorAR2260178. of f3lMu.or2o0c0h0e.miCcoalmspoIsnietneviarnoalnymteinctaallasbaomrpalteosr:y rReeppoorrtt oNnutmhbeerquaFnAtCitTatGiEvNe-a0n2a1l,ysis. `AdGmEiNn-i0s2t4r,atGiEvNe-0Re3c0o,rdGEANR-202363-,02L0R2N.-W2491, W2845, W3197, E0O-1386. U.S. EPA 2nd 3r1a.ng1e99o8f.PFWOorSk(ipnpgb)melemvoelrsaInncduurmreonntdaantda qhuiastloirtiycaalssheusmsamnenptop(uolfatthioenms)e.anU.S. EPA Administrative Record AR226-0036. base3dM.fl1u9o9r8o.chTemSiCcAal8s(e-)DoscukpeptlnemuemnbtearlsnBotEiHcQe:-1s1u8l0f-on3a7t3e;-bSaEseHdQ-a1n1d80c-ar3b7o4x;ycylicBEHQ-0381-0394; BEHQ-05980373. U.S. EPA Administrative Record AR226-0540. deveClhorpismteinatna,lMSa.n,d Hpoebrienramtaaln/,poAsMtnaatnadl Yroerpkr,odRuGc.tio1n99t9o.xiOcriatyl s(tguadvyagoef)PfFeOrtSilitny,rats. `NCuomnbdeurct4e1d8f-o0r038M, (SSttu.dPyauNlu,mMbNe)rbTy-6A2r9g5u.s9RReesveiaerwchedLaibnoOraEtCoDrie1s1,-2In1c-.02PrHotaozcaarld Assessment of Perfluorooctane Sulfonate (PFOS) and its Salts. `expUobseeld,tFoAf,iuSoorroecnhesmoinc,alSsD--aanpdreRloiamcihn,arDyE.rep1o9r8t.0.AHmeaIlntdh sHtyagtuAssosfopcJla4nt1(w8o)r:kers. 584-9. `enzGyimlelsa,ndli,poFpDroatenidnsM,anadnedl,chJoSl.est1e9r9o6l.: Saesrtuumdypeorffolcucourpoaotcitoannaolllcyaecxidpoasnedd hmeepnat.ic AAdmmi)niIsntdraMteivde2R9e(c5o):rd56A0R-282.6-R1e1vi3e7we(pdaignesUS15E3n-v1i5r5o;nmPeOnFtaplaPgreot5e0c-t5i2o)n.Agency seruBmurrfiusr,oJc,heOmlisceani, lGeWv.ei,s MiannSdueml,itJoHmaond3MScehmupmlpoeyrete,s.JCF.in1a9l9R9e.poDrett.er3m4ination of CReovmipeawneyd, I3nMOEMeCdDicHaalzaDredpaArstsmeesnst,meEnptidfeormiPoFloOgSy,(A2va2i0l-a3bWle-0o5n,ilnFeYIh-er0e5)0.0-01378. CharUleSsEAPuAer(U(SEPEAn)vitoroOnEmCeDnt.alU.SP.rotEePcAtiAodnmAigneinsctyr)a.tiv2e00R0e.coErmdaiAlR2m2e6s-s0a62g9e.from Environmental Protection Agency (EPA). 2002. Revised draft hazard 000323 Environmental Working Group | PFCs and PFOA: A troubled classofchemicals used in ScotchGard, St... Page 7 of7 aAdmisnisstraetiovsfepResercfolmurodreAooRcZnt2a6n.ot1l1c3a6c.id and its salts, November 4, 2002. U.S. EPA pota3sMs.iu2m00s2al.tT(S1C0ACA8(Se)nusmubbestra)n.tiUa.lS.risEkPAnoAtdimceinoins:trpaetrifvleuRaercohoerxdaAnRe3s2u6l-f1o1n3a6t.e `InchoimbHpiuot,iuonWnd.s,ofJIgnoanrpeastf,uinPvcDet.ri,oanUnapdlhdIaonmlt,pehriBcnLe,kiiaTdrrnoecsyokome,mpiutJnh.ie,lciaLatlaiuc,oenlCl bIaynngpdserGiflnleusVoyir,irnJPaa.tne2dd002. `Sprague-Dawiey rats In vivo. Toxicol SI 68(2); 429-36. Dece`DmubPeonrt.172,00220.01T.heU.Su.pdEaPtAedAdcmoipnyisotfraDtuiPvoenRtePcroordduActR2S2t6e-w1a0r6d9s.hip on r(eopxeyDa-ut1Pe,od2-ndetotshHaaesnakeendldilya)Lnaaeb-logrpaehtn-oernryya.dtir2oo0n-02or.meperRgoeads-uuhclttyiscvroeoftxaoynxeiotrlhayelrsg,tawuvidatygheInalcrpohamasb-iffolnueodrpoo9-l0y-day. o(SuCmbAesSgtaaNnu(cm2e-bhCeyorndtr6ro5oxl3y4eAt5cht8y0(b4TpS;oClAny)on(S-deHicPftYui)oo.rno8Um(Seet)EhnaSniuerb)omin(sm1se:in1o)tna(ltReePlcroeomitevercetd8iofmnrooAnmgoee1nt0ch/ye1:r5)/T0o1xic tHhirtu w12w/w07./0215:a.BgE0HQv-/1o0p0p1-t1i4n9t1r5./tNsocvaebmeb/edro5c,/2B0e0s1.u5b0Av1/aehi1lia0mb1l.e online at (Pe2d0i0a2Ot)lr.siecnF,pianGarltWi.Rc,eippBoaurnrttr:sisiI,nd1e2nt,girfoiLcuuapntdiAobnesrotgfr,efpJutKoo.r,coocHchaeenmcslieicnnai,clasKl).it,hihlMauinmndaveenls,tsieJgrHaat.iaonTndi,.ZSotbuedly, LR c`Coonmdpuacntye,d 2b3y0C-o3rWp-o0r5a,teStO.ccPuapula,tiHonNal Medicine, Medical Department, 3H SeruBmrihsal,f-MI.,veOslosfesne,veGr.d,l Sfiumoprsoocnh,emCicaansd: MaInndteerli,m) R(e2p0o0r0t).#1D.etSetrumdiynaStpioonnsoofr 3M Company, Corporate Occupational Medicine Department, US EPA AR226-0611. fPaluulo,3ro.McIaN2rb0bo0yn2sE.xuAysngiaenlgnyseRixesyosgefaernpcohmo,leetSdhtoahtduemECaxotnl1l-esg0ee2r,3a-Pa0An7.1d.SppRlaeanpssomorart aspntrduedpmyaornreiudkmefboyerrsaeMEr:Da3fS-to.r 1105721); Exygen Study Number: 023-082 U.S. EPA Administrative Record AR226Next Page: PECs lst forever. ifogeng ors 000324 Environmental Working Group | PECs and PFOA: A troubled classofchemicals used in ScotchGard, St... Page 1 of8 LT LA i TASES 0 PFCs GLOBAL CONTAMINANTS on, pSTeAtINMASTER J. sepomrome om Co mmeieeETTG mer People Even PFCs Last Forever 44 ROA i. comply resistant to odeadain" EEhPotAo:lIysOeAolrsblpoederasriadaenuinndtehresemnavrioonnmmeennt,t tConddoitsionnosk."d[EhXUsER,c | Full Document] Cm TT en Ba Speed isof the enam.en Ay nh con is wi Be A: essence inthe ongoing government reviews. Every new molecule mmr on Tr e ven OA werree banoned tcodayrthe lFoboanel3o5muaodsvocfooPmFSeOAtoweoplBdlcooodngtain0 ts tn Lnh. t es hk enn ER od robo aman ar -- -- essen ------. Recommengations for Actin. en PECs Global Mass of PFOA will increase and never decline after it is. banned, unlike any other environmental pollutant 50 pc r ree giam H ii w oF `Searchable database: PFC documents x 100 AT ee) 7-- on -- 55 prt0comAput C16 icine)Ooetel utd ee F IN EE ~~] ow mw ww [--, 000325 Environmental Working Group || PFCs and PFOA: A troubled classofchemicals used in ScotchGard, St... Page 2 of8 View assumations and retereonrcgceagsh iBcnoemtthbweieneUenSd.1w9ai7tn3hdat3nhbdirro1aa9d8b5iwhlPetCtnByosi,buwDialDdsT,udpiasnicndotvrheeerleafdtoeotddhaccthhetamhiienciaralnpsedrwsIenirspeteeobnpcaeln,naenwddefrtreooxmiucs,e Wreaking havc on the environment bEyvesnafaesr tshuebssetannacteso,iosutsudcioesmppoeurnfdorsmweedroenvpereyrlpuuoblrincaltyepdhcasheedmiocuatlainkderPepFlOaAced SPwtoeuurdseiaehIsnadwlidecraiteninctgohemtphUl.a5t.atdh1e,ytPhaFleCsofprwreomrdueocftp3ser'wssiesrtSeacnoqttuacinchkodlayrbdlmoaaakcnicdunrgSmcutolhlaetclirhvbwea,anyApSIrnottdhouecestvese,ry DuPont's Stainmasier and Zony! products, and DuPont Teflon. Ibnrdeuasktirnyg sdcoiewnntisintsthkeneewnvaisrfoonrmebanctkIans 1t9e7c6hntihcaat PreFpCosrtliskeuPmFmOAarwooyfuld resist biniotdheegreandvaitrioonnmetnestt:s, 3H scientists expound on the persistence of thelr chemicals m"iAcvraosotrgaarnriasymosf.or5ganviacstcIonmfpaocutntdhastcanwabse ocnocmpelbeetleileyveddegbryasdoedmeby. cthoautldgidveegnraedneouagnhytoirmgaenaincdmattheeriparlo.peTrhicsonddoicttiroinnseo, fmimcircoroorbigaalnisms fal fs stil common misconception `pAelrtfhuoourgihncatoemdpcooumnpdsouwnidtsh sairnegleextflruecmreilnyesrehsaivsetabnetetno sbihodoewgratdoarteiloen.a.s.e uhaovreidrearoelnysorasnaevreersubleteonfbsihodoewgnratdoautnidoen,rgpoernfaltuuorrailnadteegdracdoamtipoonu.nFdosr cthoimsproeuasnodns, innothmiosdisftiucdaytiwoansoafnttheicpierpfautoerdo.c)omponents of "does not degrade..." -- 3M (1976) SIntu1dy7d6oPneFObAy w3aMs tcoosnufbisrtmaendtitaotbeea "sciommiplalretfeilnyinregsiisnt@an1t9t7o2bNiaotdieognarladAactaidoeinm"ny aof SNcAiSen1c9e7s2)r.ep(orFtC-[9D5egarnaddaFtCi-o1n43o)f.S]yTnthheetpircimOarrgyanfiicndMionlgeocfultehse Innetwhe3MBiosstpuhdeyr--e, t.h.e.tehnevriersounltmsenotf tfhoirsesxttuednydseudgpgeersitodtshtuntahletesreecdhbeymimciaclrsobairaellciaketlaybotolipsemr"sist in ne(oEltxt,brarceptarok|cdeFuoslwslenDs,occeauilmtlheeendrta)v.qiaueStohuuebsseenpqheuortegonylotyfsSitssuucanllneidsghshtyhdoorrwoletydhsritosh.uagthPrFeOacAtiInonwsawtietrhdwoaetser Ceonlvlierctoinvmeelny,tatlhedseegrsatduadtiieosnsmheocwhtahnaitsPm:FOhAyddrooelyssinso,t pbhroetaoklydsiosw,norbyblaondyegrkandoawtinon. tihe Baodoy,naontdbrsotkaeysn fdoorwyneairnstohnecheuImainndosrtasniwmaayl iOnu.t, but remains unchanged in "Completely res--isNtaAnSt to biodegradation" 1972 000326 Environmental Working Group || PFCs and PFOA: A troubled classofchemicals used in ScotchGard, St.. Page 3 of bUnrleiakkedootwhnerinpetrhseisetnevnitroorngmaennitc, pPolFlOuAtanwtis,paeirsoisftwihnidcehfihniatveelyseovmeen cifapbaacninteydt,o and hwiullmcaonntpionpuuallaltyiorne.disPtCrBiSbutaendthDrDouTghhoauvtetdheecleinnveidroinnmteotnatl,gtlhoebaflomodascshaiin,haend the bdeectardueesfofrolPlFoOwiAn.g thei respective bans in many countries, but he same wil not Persistent Organic Pollutants 3 touts perfivorinated compounds on ls website: "SIot'mseaongaoogdignugesshathnaktssfoormethweheproweeirnstohfeSwcoortlcdhgeaarcdh dpraoytetchteiroen,isthat 5Gr0oyuenadrbsreaagkoi.ng, invisible wonder created by scientists at 3M nearly 3pe'rssisotwenntstthuadnieDsDITn,diPcCaBte'ds tahnadt tDhielldrri"nIn.viIsnibtlheewloantede1r9"70cshebmliocdaelgsrawdearteiomnosrteudies Speerwfaogremesdlubdgye,3M2 ImneddiciautmedrtihchatinPFmOicSroabnesPaFnOdAuwsoeudldinnsottanbdiaorddegIrnaddiecatInortaectsitvsattoed ene upper-bound rates at which bacteria can break down chemicals DmaDsTshoafscahermeipcoarltetdo hbraealkfdoowfns)evien nachtoiuvraste(dthseetwiamgee rselquuidrgedef,oranhdafathhealoiritgeinoafl umipxttour1e5cyaellaerdsAnroscollorf1e2d42plodtes.gradeUdpatfote6r628pedracyesntofofetxhpeoscuormemetrocaicotlivPaCteBd SSoelwafigeeldsplluodtsg,e.| IDniceodnrtirnashta,sstbuedeinesreppearrftoerdmetdo hbayvIeMhIna1I9f7e6 aonfdse1v9e7n8ysehaorsweidn dtheagtraPdFeOAa, aPlR,OSe,veanndinaatchteirvatteerdmisneawlabgreeaslkuddogwen, GpirvoidnugcttsheofmPaFnCipnfriondiutechtasfdofneo.t Pa`SRnoOdmSoetwPheFerreCstceabprramebialnekalodfopuwrnondd,eurcbgtuosti.ntgLhaebtiebordresetgaurdakiddeaostwiionnnd,icchbaauttiendanstahtlaoytpsisssoaomtfePtPFheOFAC,rPelFaOteSd to nbioond-ebglroaddeagtriaodnabplreodPuRctOsSraenvdeaPlFedOAthatt(hFeisguerech1e)micals decompose to terminal, Figure 1. (Excerpt | Full Document] mgm gen moe Sep com 2, wR kc fFulouroortoetloemleormse,rsusberdeiankSdtaoiwnnmasitnetro aPnFdOAZ,onwyhlipcahpenreavnedr fbarberiackpsrodtoewctno.rs,Of the SDcuiPeonncte'sonKodrTzeecnhinoowlsokgiy,s aq5uostaeydinIgn:the Apr 12, 2001 dition of Environmental 000327 Environmental Working Group || PFCs and PFOA: A troubled class of chemicals used in ScotchGard, St.. Page 4 of8 PROS seems to behave differently from our products a[ftluaonroatseloameers1)0.0"Iamnidte"dSc0ien$ti3ficwhientfohremrattihoeny abnrdeasktuddoiwens oonr tNhoeste 151 B5CuoHtmcptoowumonpdsoesup,nadrasan,teeIpnsUtfBuaIdcikSeNIsnedsshoIonmwethtechaptseeefslrau-ortreeovtiebeliwooemddeergesrraaadrtaetuinrooent Istnone1dy9i8fa1er,ree3tnnhtdefsarnaoommtehtehre DFPieFocOdeAenglftyaamdsiapltoyinowsniotrohfeddtihfbefyelraionr.goctIaenrcbblooontmecohrfasitnrheelssueelntgssteuIsdni(PetsFh,OeAspcearenfdnutoartshneafrtoeucndhdecmtaihrcabatelxsyIlncthe sade) Fiuooorrsoeetxxeapmloposlmeeed,rst3oMhaacfdtoiulvanardtgeetdlhyastdeeawfcatogermetphsoiesuedZdgoentoyf!opreB1rA6f-tudyoapryensa,mtitexhdteucmraieorstbfuotrnleiocomfaecridaslcohols ScBoeongwtraatidonaitmniegoanbseuotrfwete.heenl5onagnedr c1h2aicnarfblounoraotteolmosmers ([1E6xtcraacrtbo|FnsulIlnDeoncugmie)ntw)a.stoo 3BSc1lioeadncetigidsrtcasodnsatttaoiPnaticwneogAponenarlefyltfuieccwnaeilrnSacetraedvribccoeansrtbehoxapxnlyaltihnaectiihdaastl(ePatFcehOoAlmeaurnr,dotraeenlldoatmaeendracahceldmoihcaalsw)i,l CoPorrnootnaeilnionmgetrwoalfceowheorl cwairhbo8nstetnh-caartbheenitnaaintberoemaeksr aGocwonn)pr(eFdiogmuirnea2n.tly toThe Figure 2. CRACRYCHERON Sivbaitoeddegsraedwaatgieonsiddge CF{_C(EP)FNCAO)OH,, CR((CPFROCAO)0H aDneogtrhaedratiimopnorbtyanhtymdernosroafdiecnalvsrainnmtehnetuaprpedregartamdoatsipohne.reUn(ittheedwNrootpioosnpshere) is RE1asnlveicraounosmfeentatiatolmoPdarsyopsgnreoanmVtgreuainddseaplyoisrnteoasrtsimouangrgieesSstuhicohaultadaabpeciocsmonpmsoeiutdnhedordewdiotfphemroosnilseatcetunmltoes1 phertihcs anspor 3GDe5DcToh,moputorhsseirPteiCsoBpnemcbityixvtheulyrycerAarxoyclFfoOarScFi1a2(6l22s,steamhnidvhDaaailtlidveienpsrheoacvfuersdboaeryeson,f rP4eF:pOe)rtot,e9do8ntdotahuyens,dteharnegdro GVReeaagnrdrs,a,d1Ia5 tpornoocpocofusrPesdOSa1Ek)aun(dIenrTgShoxisdoegforSereaavtdleayntieeoxxncpaewairdlihsmet3nhtRes,aUNfrEeesPearorfeccrhoeemramsteaonrbdstaehtraivnoend3.an7nod hBPraRoOnvSitaehnesdmiPorFriOenAaetvairededennCacotembtpehoeauvtnehdde nptoaertdueragorrisanedaaetseautdcahCiogbmrypeaottuhincsdonsmceaecrrhenanmniosrhmee.pe1r9s7i0s3t.enAtnd SamrtaeujdoeirxepsmeeIcnatdneidscattooef eutnnhavdtierrPogFnoOmeASniatoanwldhydPdeFrgOorlSaaydsraitesioa(nNi,-oEaLnrFedOsSiaEsl.ttahanlotcuotghoholhmyadnrnaosylyaPsniFsOe,Ssatndmeoarttihveeadrtives tyhderuliytsmastheaplroldeucotf6o.f3Myaerasoo.r mare than 27 years, in two studies. PROS Is 7CSot2no0cwe0rb0nr.ebaEekPcdAaoufwsonercroeafdtce3osn1ocfetrocnopsnhsaaubsmoeueotrutcpururosrdeeuncottfec1vh5eemSsiecooatflcPshRgtaOorSdPIFSnOFShOuSamnacdhnePmbFiiOcoAaoldIss in May vT0leamtsotn3emoostlfearvoellmsacbsoehnlocewprnrnostdouochvteirromnCrblaranbenawtneirlmeeavleilsnspIElnaPcAne'u,Srcaronenggcu.elnaIttnroarbtyoitophnosshtemuirsgeehotcnacsPaeFsn,OinAue Lo3lwoinmseenrInstlhhceuomenaonlnv,ibrtlohoenomdaenang5iohnveaerScscheoevtmecirhcaaalalrsddencIancdgoernsedstiuoemnhetsre,lparntodedrumoctithnsearl(sS)dt,eagsmrlmaodawaslttyieborrneak Broducts -- PFS and PFOA. 000328 Environmental Working Group || PFCs and PFOA: A troubled classof chemicals used in ScotchGard, St... Page $ of8 Some PFCs can build up inthe food chain to concentrate In humans. IASnRdshiocauEtgneihhreatnamlPenbCtiaolcwoLnadcbeonrtharotavoteroynthfseotuupndodiethseaonn!sPthECbSexwupeoruespenototwehifetfhu1o0eu0nt0t rcrohoarm:,thItenhe$y97d5d, CGCFoonPmcEpaGadSneyad'ntdDheStceaahtteucrsh,gsaArcldoa'msbapamaawunuIsangrbroeacdlhideenurtpm,Nc-aasEbpFolOcaoSnnEcn-easdmceSanienn,tiinTchaTeenhS;cuotnhcoresniatons i1H0oh2r0et03s1,admineceeosxmertakerancrhosssudPpeCptBoesrrtmeidnebdwyhhHiaeekahlstshopmCieatnePaFdtCshseiacrnohdladvEinbnvgidrboenuempnennbtatnChnaeenadfdomaodo,rcehain hwaantearsquaarctteosr of3a8csaintteusry 90, annus 3 render esate sh ante ta at nPShFdoOwAasaitdakatnnotwrhnaertcoeFcrEoCSnsothraoemviesnhaavmteuhsceh({E0ex0tddracichtea|FnpuolnltcDueodnciunogmewpnitod,lfebsut,thMteahferoridswsiusdptpely,y. TCihokeempOboaucNnodnscaairnnttbharteoaFnkOdfoRawcntfoarpsmroi(dBrcCFteas)Eoqrfeu(pyboarrietcendtnfotdo tpshaoopmseeer ofrofartthPeCcBstl.oonnTgho-ercshemacuihnoemnicsals, (ae Table 1. Pro(Tefion, | SpTeaeflntoeno,nbrreaamkdrToeowtnmon . Smear | psuecer s0s08 | `CSthaienmeastear naned s | Po ronenadn o | reSeSartdoempnrodtdaunecat sGroomscrgur| SeocrsioStxetciogmmd rons | 100 . 150 ! | EH JnOmR eS~ nasnenoels cernaeatymiaaorn,s| 1o0atoassuo Some CrSHorEmoNan"1r1on|| roGeeSssrttoeomnrtpeerroaadinusac | 2700 +400 GFsreooronih]1(2r.on|| roeabkdeonrn porodnuct | 16.000 +2700 Ctarzroiisdnerson|| roeteSesrutdmonntnozporioadnuecat | 23000 +5300 rungs, 1| mes,praonddruecaes, SREY! oouncd ]nist | froSateecadermuaicnnatasernosiuynd Bere | Notests ovine Notests oan Notests seine eSouerced: Enevriartoinvmee.ntal Working Group compiaton of BCF data In the peer References: 000329 Environmental Working Group || PFCs and PFOA: Atroubled class ofchemicals used in ScotchGard, St... Page 6 of 1. 3PrMo.te2c0t0i0on. ABgioednecgyraAddamtiinoinstsrtautdiyveofRePcFoOrSd. NUuSmbEnevrirAoRn2m2e6n-t0a0l57. 2. D3eMg.r2a0d0a1t.ioSncorfeePneirnfgluSotruodoicetsanionicthAeciAdqu(PeFoOuAs).PhUo.tSa.lyEtiPcA Administrative Record AR226-1030 Photolysis 00-2192. 3. U3.MS.. 2E0P01A.AdHmyidnriosltyrsaitsivReeaRcetcioornds oAfR2P2e6rf-l1u0o3r0o2o0ct9a0n.olc Acid (PFOA). 4. 3`wMw.w.Ab3omu.tco3mMja,baovuatl3lma/bilnenoonvlaitnieona/tinventors_hall/index.jhtmi. 5. HbiSnD/Bs.isD/OhTt.miagveani?lHaSblDeB.online at hitp://toxnet.nim.nih.gov/cgi6. HSDB, rciHTH. 1981. JWater PollutContr Fed 53: 1503-18, 7. IBnisotaictuctuem,ulHaRtOiWoHnCDIaAtTa. o1f99E2x.istBiinogdCehgermaidcatailosnBaansded on the CInSfCoUramaptaino,n JCeanptaenr.Chemical Industry Ecology -- Toxicology and 8. CU.oSm.paEnPyA,AdMm.in1i9s7t6r.atBiivoedReegrcaodradtiAoRn22S6t-u0di3e5s6.of Fluorocarbons. 9. E3MP.A A20d0m1i.nisEtxreactuitvieveReScuomrmdaArRy22o6f-1Bi0o3d0e2g1r0a7d.ationStudies.U.S. 10. `RCehenmnicearlRs,.. 2E0n0v1i.ronG.roSwcii.nganCdonTeccehrnnolo.v:er15Pe4rAf-l1u6o0riAn.ated 11. SBeirovdiecgersa,daPtA.ion200S2c.reeBnioSdteugdraydfaotrioBnioSdteugdryadRaetpioornt;Screen Study AfoRr2T2e6l-o1m1e4r9.Type Alcohols,. U.S. EPA Administrative Record 12. eUNwEwP..ch1e9m9.9.uneapva.iclha/bploepson/lPiOnPeSa_tInc/INC_2/enfinfs/inc2_inf2. htm. 13. S19y9r3a.cuCsheeRmeossepahrecrheCo2r6p(oarsatciiotne.d, iMnetyhleaHnSWD.B)M:. a2n2d93H-o2w2a9r9d. P.H. 14. S3uMl.fo2n0y0l1F.luIonrdiidreec(tPPOhSoFt)olbyysisFooufriGearsTeroaunssfPoerrfmlIunofrroaorcetdan(eFTIR) Spectroscopy. U.S. EPA Administrative Record AR226-10302104. 15. BMairotcionn,ceJnWt.r,atMiaobnurayn,d StAi.s,suSeodliosmtroinb,utKioRn aofndpeMrufrlu,orDiCn.at2e0d0a3c.ids In r(1a)i:nb1o9w6t-r20o4u,t (Oncorhynchus mykiss). Environ Toxicol Chem 22 16. AEdPvAi)s,orUieEsP.AUa.va2i0l0a2b.le Uopndlaintee:at:National Listing of Fish and Wildiife http://www.epa. gov)watersciencefish/advisories/factsheet. pdf. 17. UofSPEFnOvSi,roFnOmSeAn,taalndPrPotFeOcAtifonroAmgevnarciyou(sUSfooEdPAm)ai(r2i0c0e1s).usAinnaglyHsiPsLC electrospray/mass spectrometry, 3M study conducted by Centre. 000330 Environmental Working Group || PFCs and PFOA:A troubled classofchemicals used in ScotchGard, St... Page 7 of8 Analytical Laboratories, Inc. Notes related to graph Assumptions 1. A8.s6suyemaersd. eWnveirfoinndmennotasltuhdiaels fthaftormCe-a1s0urfeludoergortaedlaomteironalocfohCo-l1:0 uennvdierronnomernmtaallehnavlifriofenmfeonrttahlecCo-nd1i0tifolnuso,roWteeleosmterimaaltceodhaalnby sincaalsinsgumtphteieonnvi#r4o)nmbeyntthael rhaatlifolfoef fhoarlfDiDvTes(o1f0.t9heyealacrosh,odleatanidled DOT in activated sewage sludge (where DOT degrades by SO 1p9e5rc%eonft Cin-1s0evdeengrhaoduerss,inac2c4orhdoiunrgst(oaJcoehn2s0o0n2)()1976), and where. 2. rIantcerseaosfesC-I1n0fPlFuOoAroatreelocmaelrcuallactoehdolb,asaesdsoumnipnrgedtihcatted12b/r1e3atkhsdoowfn t(h2e00m2a).ss of thealcohol converts to PFOA, consistent with Pace 3. I1m0plfilcuiotriontetlhiosmefrigaulrceohIsolthaendasPsFuOmpAtiinonthtehaetnvtihreontomteanltm,oaltestohfe C+ time PFOA Is banned, are equa. 4. oAbssseurmveedd 8en1vpierrocnemnetntdaelclhianlefiifnebfroerasDtDTm:ilk10i.n9Gyeeramrsa,nybabseedtwoenen 1969 and 1995 (Solomon and Weiss 2002) References (graph) 1. Johnson RE. 1976. Res Rev 61:1-26. 2. `PBaicoedeAgnraaldyattiicoanl SSecrrveiceens.St2u0d0y2.forBiBoidoedgergardaadtaitoinonStSucdryeeRnepSotrutd:y fAoRr22T6e-l1o1m4e9r.Type Alcohols. U.S. EPA Administrative Record 3. SbroelaosmtomnilkG:M tainmde PtrMenWdeisssa.nd2r0e0g2i.onCalhevmairciaablilctoy.ntaEmnivniarnontmseinntal Health Perspectives. 110(6), A339-447. Return to graph Next Page: PEC HealthConcerns. info@eng.org 000331 Environmental Working Group || PFCs and PFOA:A troubled classofchemicals used in ScotchGard, St.. Page 8 of8 ane Scotchgares 000332 Environmental Working Group || PFCs and PFOA: A troubled classofchemicals used in ScotchGard, St... Page 1of12 PFCs GLOBAL CONTAMINANTS STAINMASTER roth PFC Health Concerns cern OO... 4. eS i pease Fueshers ETC LamsFocwrer sala " Industry's mast recent study shows organ weight changes -- often a gross sign of toxicity and datm o ora ganfg uncteion -- amonglab animals expotosPeFOdA in `the womb and into early adulthood. [Reproductive effects in: males | females) Ponts Spin About PEOA : T Sguiatory Gans PEC Pollen I fecammendntionsforAction PECs "Shoppers Guideto PFCs. 000333 Environmental Working Group || PFCs and PFOA: A troubled classof chemicals used in ScotchGard, St... Page 2of 12 PFOA levels in human blood overlap with levels in laboratory studies that cause harmful effects' "0 3 1,JnPFcOiAblldoeond levels g ene ts3t 10mm rts ou: aad ins: md poe Eo g3! (7 ti ect12t0 ppab, eSsdtimdatteat d re: cs emeun, oesof er 0CpEpsl. eestmimated co seston Li 3 10 PFOA -- Dose fed to ats (ma/ha/day) s000 "0 3 fom g2 5i 20 g 1000 [----r-- FROA bla tvs fn workers enon fm nc,500) 71.000 pt tf[ hesrco-- rnete o-- s a mono es Se a FROA -- Da3e0 fet ts (mia) [T------ 000334 Environmental Working Group [| PFCs and PFOA: A troubled classof chemicals used in ScotchGard, St... Page 3 of 12 "tTehstrieceuloafr,thberefaosutr,tiuvmeorrasncdauprsoesdtabtey.PF[EOxAtraarcet]oPnFtOhAe arlisseo Icnaupseoepsleh,ypiontchlyurdionigdism 4in.6l5a%b pseturdcieenst, oafcAomnedriitciaonnsi,nkmeodsttloy fwetoalmberanin.dLaemvaegles.ofHyPpFoOtAhyIrnoslodimsempsetorpilkee'ss bodies now appear to be n the range known to harm animals. aEnPaAl'yssins eofwhfuimnadinngrisskoffrhoimghPFrOisAketxopohsuumraesnso.n ErPeAciensiotpfigtaatmedajiotsrInne-dwepstthudy, tSopoPnFsOoAreIdn buyte3rMo,thInro2u0g0h2.eaIrnlythaidsulratthoroedp,roadnudctfioounnsdtdudaymascgieenttoisotrsgeaxnpsosinedanriamtasls exposed to the lowest doses tested . (Reproductive effects in: males | females) aAtpptrhoexilmoawteesltyd4os0epatersttsepd,erwibtihllloenve(lpspbo)f,PtFhOeAofifnstphriengmawteerrenaslmabllloeordaotf bith and twheeigahdtulgtaifnemaatlceerrtaatisnetxipmoessedin iynouutnegroa(dFu1ltgheonoedratio(nExftreamcatlse:s)FLdencerwebaasrend,bFoLdy. madautletrbnoadlybwleooidghatt a|pFpurllodxoicmutmeelnyt]1.20Atpptbh,reteheofadfuolutr dF1osgeesnetreastteido,n bfeegmianlneinrgatsw.ith 2ha2dMdBecfirlee]a.seTdhegrpoiwttulhtaorfytghleanpidtuisitoafrtyegnlcaanldle_dth[eEx"cmerapstte|Fruglldlanodc"uImnetnhte bNoodtye: gbreocwatuhs,e mitatseercnraetlescahreo,rrmeopnreodtuhcattiornegaunladtememtaabnoylibsomd.ilyWhpreoncetshseesa,duslutchF1asfemale orfattshgeaFv2e pbuiptsh wteortehe"ifroouwndn dbeaabdlesor(pcarlelsedumtehde cFa2ngneinbearlaitzieodn"), "a(gErxteraatcetr|nFuumllber adlotceuremde,npterNhoatpes: b2y2dMaBmafiglee], toThtihsespuigtgueitsatrsy tghlaantd.matAeltrenranlatciavreley,cotuhled Fh1avmeotbheeerns hmeaaythhy.ave ignoredorcannibalized pups because the F2 offspring were not (Atpphmi)ghPerFOdAosiensmiantetrhenarlatblroeopdr,odsuecvteinonofst6u0dym,acloerraensdposnidionfg60tof1empaalrte poeffrspmriilnlgon [dEixetdra[cEtx]t,rawchtic| hFumlleadoncsumtehnatt)P.FONAo iesxmceosrsemtoorxtiactliottyhweasyofuonugndcionmppaarreendtatloaandiumlatsl.s 2u5n.t2regartoeudp,rattsh.e Wmhaelen osfcfisepnrtiinsgtswaeurteopesmiaecdiattheed,macloeldantod tfoeumcahleanodffslpesrsinagc,titvheeythan tfohuynmduss,igandifriecnaanlt gclhaanndg,eksidinneeyi,ghptroosrtgaatnes,,tiensctleusdainngdtehpeidbirdayimni,dleisv.er,Bsoptlheemna,le and faletmearleed orfefpsrpordiuncgtrievaecchyecldinsge.xual maturity later and the female offspring also had 34 Mppwmo,rkaenrds aisnvhoilgvhedawsit1h14PpFOpAm pirnooduncetiwoonrkteyrpitceasltleyd.haDvuePbolnotoddoPeFsOAnoltevreelasdialybove ldiitsicglaotsioen,womrakrekredPF"OPAerbsloonoadl laenvdelsC,onaflitdheontuigahl"a sdhoocwusmetnhatttmwaodeofpuebilgihct nwormeceennt t1esptpemd. at[FutlhleDWoacsuhmienngtt]onAWroerckenstlpylapnutbliinci1z9e8d1ihntaedrnPaFl ODAuPbolnotodhlaezvaerlds ahsigsheesrsmtehannt Sachcouwmsutlhaatte pbeloopoldelwevheolsdrofin1k pwpamt.e[rEwxittrhac3t papnbd PEFWOGA afnoarlsyisxisy)eaPrFsOaAreIsefxopuencdteadt to his level In drinking water supplies near DuPont manufacturing facilis. EmPaAmmclaasrsyifiaensdPlFiOvAe atsumcoarrcsininogreatnsi.c in aWnoirmkaelrs,s ceaxupsoisnegdttesotiPcFuOlaAr,hapavnecreelaetviact,ed rriespkrsodoufcdtyiivnegtfrarcotm, ionrcsluedeiknigngthtorseeatomfetnhte ftoerstciasnacnedrspof rtheop[anEscWrGteWasoarakntdermSeatlue.dy. dDuorciunmgetnhte]pTaesstti1c0ulatro,2b5reyaesatrs,.a[nEdxtlriavcetr]cLainvceerrchaancveerbaeleonneInhcarseaIsnicnrgeiansetdheanUs. estimated average 4.7% a year between 1992 and 1999 cFaivuesisntgudiinecsrehaasveed slhevoewlns otfhaetstPrFoOgAenalatnedrsarbenporromdauclttiveesthosotremraonneesreignutlhaetimoanle=,= I1 nFculrleadsoecdumlente).ovfIenestrarltosg,sePnFOhAavaeltbeersengrfoowutnhd oifn tehxepopsroesdtawteo,rtkesetirs,s. [Extract `epididymides, and seminal vesicles. tEhleevtehnyrsotiuddigelsansdh.oIwn t2h0a0t2P,FmOoAnokreycsheemxicpaolssedthtaot PbFreOaAkfdorowonneInmtoonPtFhOdAevdealmoapgeed Haynpuontdheyrraocitdiivsemtahfyfreocltds, aanceosndtiitmiaotnedcal4l.e6dhpyeproctehnytroofiAdimsemr.(iEcxatrnasc,t)mostly women. iHmyppaoitrheydrogirdoiwstmhcaanndiImnptaeilrlebctruaailn ddeevveellooppmmeenntt., leading to hearing loss and 000335 Environmental Working Group || PFCs and PFOA: A troubled classof chemicals used in ScotchGard, St... Page 4 of12 eFoutr oetregaa Insmormdtooisssneuees iPnnRtahOreetiTmhrmouorneessonfytPsEtaOeRmaand atthTgasmsrifnree thSypveeesnos:f cpovlethat oaSoefmasr,avCaeancferrerhderonotmttpitaotntrtaoysts rhofeavsieucsbyeIn.ndedTceornessieseelddoctgehletcmomimigmshactmhccaoltuiaaonln:htoow PyFOA BSeensramee proosllGatuoen,snsreSvocet emvoersmoofnctorsopn ond decsessed els of Cancer. TEPhnoeeanfefdteoreualcaganocveerarsnmheanvrte pcoenmnsidmecrasrePaFiOoAgntndtohbseocmUaSracpimanrpogi.etna--n(coaeukSseihnngtevyreea,orfs areennntCoovnmcremitpnekrsofoacnaernonrlodtmewSnoomaamentieT3hei1k0In3Sc5edveenrees dfeceadehs lamdaterheoawhhees SIntoomeerssytweeea:rrceSaotnoucunepdrs itSneuvSeehisoepseospfa7ens6st.re1es1dt9abr)yoSr3xppoaasnnedasSD5auPdSaPbOrR,r.onosneIonfCtohxneIrn0ad,awttsshsne eTimnersonemspoosyescpoonratnooaym4i.sPEON doch he eden of mary o5aF SoheacssosneenSnoepernoTborloefrmtsailmtahwotcrhakeesveresrKinedesosdfcoanccerarasppotae:medaannrdetpheaisrnewoertskeerscsanoacfseYrweoSrl erenaeseo eat oepthoteehsCrohmaeStiIyannEeayDsooefscsuavomsnea)freeBnsaceogwnowsekeaerrSstoubedeSssaybppaeag nsBROseeptSisnb:iFaohsskneooutB5eFceOonNsseacmaoltsohmaeidne:attonhnekIbsehaeosreeasn Haomhooeds.fesncneoevraesrosarnd oo Breast cancer ASTEmeopnaaagrtierisaanbrtoonyetoadahay,emamneein1i9B5gr5hetaensdec1xo9ppe5c9eteidnntwoaogmreaynrnetoaesssscae5neaornnasynvdoeutanangpeeerionf rpe siautmitmtesSsof tAaoseEo wopasreaonteorn Eotutd TmFraanoseoptios croetst Testicular cancer. AoTCRsecurecesreapatncie,obntuhst(n3e3cdy7eean3rcs)5o0f1datte1hs55t6i0..l3a.ancivahnecrieorcoaeerd1eo1sl.i5onfpgterbecoetnuttrpaeevmerveyesrotne UPOREaS mWehtiraoerosb f Bofatneosarsacanncemrechposnieuwesebdtoindreasp3p9ir6i5oofn3o5Barndor3o0od{3hand Prostate cancer. rrBoosnUtatSeGaScmanicnegr Soraortretseorhonsese 14p3.47e5epeTaroicteeontnPraStyheooaferth1bi3es9t5cw:eeetahns1eo9d7od3noanbncdeeo1p9p9ai2,ndoeecdimneoasrr:e Beeaishttteocttmoonc,roabnonat nnrewesieseedbanataeorannBcee5.vteeatecaonSetenaspcsceaomrpaaHromiseeadtneba ycoonmer is Worker studies show increased rates of developing and dying of certain 000336 Environmental Working Group || PFCs and PFOA: A troubled classofchemicals used in ScotchGard, St... Page $ of 12 h3iMghweorrkriesrkss efxopcoasnecdertos hoifgthhelemvaelleofrelpurordoucchtievmeiscyasltelimke (P1.FO+A, {aEpWpeGaWrortokeberat SptllaindtyDfooucnudmtehnatt]ChMeomritcaatlyDisvtiusdiioens woofr3kMerwsowriktehrsteant otrhemoCroettyaegaersGroofoveem,plMoNyment woetrewo3r.k3 tInimPeFsOmAoprreodluickteiyonto:ie(Eoftrparcostt]atIen ctwanceorthceormsptaudrieeds,toonweorckoenrdsucwtheaddiind ChdooacttttoaergxefpooGsreroedoavwseoo,rnksHeiarssasonhcdaidattheeeldeovwtaihtteehrdharativsaikn3fgoMprpdolysaitnnatgtieonfcDapenrccoasettruart,1eA.cla1an.bcaeWmrhaio,lre3v1ipsrtofisontugantdtehe GCiasnecaesreIs--fornylycaobomumteonneamIon n3g0 owlidlelremefnro--m pornoestIante5 coarn6cewrilalnddev5e0lo%potfhemen iIdnehcaitdhpernIoncsetmaaetmneocwnaognrckweiornrgkweirnis,tdhbeuatcfhIeenmrsittcehaaeldavsgtieusdooifen7d9ocfau3sHe3wo1fascdhe5oa4ts.he2.nyToehtaetrosavs(et1ruadygecaangceerof dWSithdui,tlletehstehsefhsionewditinwngogs stahtrauetdicteohsnesdipisrdtoensnotttatarecerpioosrastttsahtraegteiwstotriockraeglrlaynsetolufedviPaeFtsOeaAdnrdisaklWsloiokrewkiGetirhlsiaainnnidmtahelet a. owrodi3s0eapsleaantnsdaarneyatlysopemorfemakleelretporoddiuecoirveseterkacttrceaantcmeern,twohricphanIcncrleuadteisc. cancer ti2e5ssctciaocsumelsmaro15annnIdontpmhreoisgnthaatstehpecraonfsceteart:tiemcarnicekrf,oNeaindtdhyeitrnhgepaoinfkcperaleniacntrioecoadto iocftdecsyatininccgeulrfarrsocmaabntochueetrsseonaree. idCneo'am8t7mh,oaannn,ddtnfosort tidelisstteihcaeuslemaorirncceaindtcerenorcueba.lbiBoneugcttah1uaistneId5ny0ci0rn0egasferorAmigsatkihsne,wsee3rt1eypnsetosutodefidecdfaoncractuehsreesIeos fnot Gtihseeassteusd.ieIsfcPoFnOdAucItsecdaubsyin3gHtwhoeusledafbfeecnteseidnewdortkoefrisn,d astmatuicsthicallalrygesrigsntifuidcyantthan eafnfiemcatls sNteudvieerst.heless, th patarns of cisease are remarkably consistent with WpAlroleuovlfedntttheecnowdnoctrlokueasrbivssectuuirdneiteetrshpecreoatnbaidtluiicottyneoodff bssyctiue3dnytirsaetnssdulttoDsu.dPiToschneetrnfhlaeavxwepsosisinugrtniehf-eidcwraoinrvteklnearhwessatluttdhhiaets EpEfaxfrpetocitscset,damrolafykiucnonmgepxetplholeisnemgda.ncFyaotrefgienoxdriainemgspslboeaf,sheiendaslotonhmJehoabsrtomucsdciuIepnsavt3aiMroincolutasosswsioefireekdIefrwtohsretkrueedriwesesrineto Wf2oesrrtkeuednrycsepaasrstiina5l0dlyiUssbeplaoasnueisstoborueestdwtbehyaetn3JMtohbceoshniescwtloourrdykeedcrotsuhladtnPoFtObAe"cuYosenett,damiainsn1aa9t9mi6oe,nasaauumrtohenorfgosraolf exposure luWeneveexlespxsopisemceitdegdtrtoohueptghberaosgueepndeoorfanlwjoporobkpeuhrliassttwioorhnyo.twoHeohrwaeevveseertlo,etcawtleesdeffroouurmntdhfeltuhoartintheis ghHiragothueJproobtfhHawionsrtlokerevyreslwsawsraesnpoontrottaendunafecoxrcputorhsaeetgdee,mneehrtaavilicnpfgooplueievaextlpisoosn2u.0r-eW5.e0 tciomnecsluded Hypothyroidism. IodnawmenalegvneetnotosPttFuhOdeiAe,tshyIcnroomnioddungcklteaeynddsbfaeonltdlwoeowetihnnegr1e9ax7np8iomsaaunlrdse2t0o0P2,FOsAci"aeTnnthdiesctdhsaehmmaiavcgeaeldsoIntchcualmtuedbenrsteeadk cIeowlllaevreelsffoefcttshyornoitdhehothrymrooniedsantdhathycpoontthryolrogirdoiwsmt,h aancdonmdeittiaobnolcihsarmacatnedritzheadt bayre critica for proper brain development. eThsytriomiadtecdan1c0ermialnldonhyppeootphiyerIonidtihsemUaSrehacvuerrhenytpohtuhymraonidhiesamth c.oTncheerncso.ndAitnion is opfroppaertricburlaairn cdoenvceelronpminenptreIgnntanht fwetousm.enSmbaelclaruesdeuctthiyornosidinhomratmeornneaslatrheyrcoriitdical or cRohrimeonn.e levels during pregnancy have been assacited with reduced 1gs in ItInhnyc2rroe1lad9s9ehs8oirsntmtuohdnyyeroorltedtgshutleiamtCiuooltnattanignegwoGhrrokoerormvseo.,neMHeI(dNTiSpclHaal)ntsI,nta3wfoMrmkfeeoaursnsudrwieetdvhisdhieigngncihefeirocafPnaFtlOtAered blood levels (TSH Findings: 1998 Study | DuPont SummoafrTSyH | 000337 Environmental Working Group || PFCs and PFOA: A troubled classofchemicals used in ScotchGard, St... Page 6of12 DuthpyoronitdHaanzdarredsAusltsiensgslmoewntth]yrHoiigdhhToSrHmolneevellsevaerlse;otnhee spiigtnuoitfarayngulnadnedrIancttihveebrain wil secretes extra TSH as a signal to stimulate thyroid hormone production. eInvdeursytgrryosucpioenftisPtFsOfAo-uenxdpoasterdenadnitmoawlasrIdnsade2c0r0e2asmeodntkheyyrosltduhdyo,rm1a!ne[Elxetvrealcst]inand idnocwrneaisnetdo cPeFlOlAul.ar10d-a1m.agTeheincetlhleultarhcyhraoindgsesofarraets tehxepsosaemdettoypcehecmaiucsaelds tbhyata break pthryorlooindgetdumsotrasteIonfrhoydepnottshyroidismDaunPodnatrehaaslsnoeavsesroctieastteedd wwihtehthdeervetlhoepicnhgemicals that break down Into PFOA cause tumors. `aTlhsroeteanrgeewt stthueditehsyrsoihdo.wAtlhtahtoucgohmpdeotuanildesd tshtautdybrIenafkordmoawtinonintIsocPlFaiOmAedInatsheCBbIody [(ECxotnrfaicdte]n,tiparleBseunstianteisosnsInmfaordmeatbiyonD)uaPnodntretdoatchteedEPfAroimndtihceatpeubtlhiact rtehceotrhdyr(zo3i)d was. adotwanrgeitntfoorPFaOlA.of the[Efxlturoarcitna|teFdultledloocmuemresntte]s.teDd,uPionnctluidnitnegrtphreotseedktnhoewsen etfofebcrtesakas "pnroonvi-daeddvenroseinpfhoyrsmiaotlioognicoaln rtehsepospnesceisf,ic" tbyupteusnodfereftfheecitrs csleaeinmi:of "CBI" privilege. Aunnexupnldaeirancetdiwveeitghhytrogiading,lahnadirIlnosasd,ulatnsdclaonwleliabdidot.o fMaotriegues,erdieopurs,eshsoiowne,vearn,xiaertey,the Inefffaencttss oafndthycrhoiliddrhenorwmhooneexdpiesrriuepntcieonmfoorrethseigdniefvieclaonpticnhgfaentguess ainndhocrhimldo.neFelteuvseelss, dmeavyelsoupffmeernmteonrtadlefriectiatrdiantmioont,orlossksiolfs.heIanroilndgeranchdilsdpreeenc,hd,eapbrnesosremdalthtyersotiidcullaervels have been associated with lower motivation to learn and attention deficit disorder cIonndtuisnturey atottdeomwpntpsltaoytohbsecuerffeecatnsdofmiPnFiCmsizoen tthhyerotihdyrfoiidn.dinIgns.a 3sMtuadnydcoD-uaPuotnhtored [mPoFsOtAl]y-bryelaintdeudstcrhyanscgieesntiinstcsl,intihcael rcehseemairscthreyr,shsotramteontehsat, "otrheurrienawleyrsies,noorAPFO. thaebmlaetoslhoogwiicnagl etfhfaetctPsF"OIAn meoxnpkoesyusr.es Yleetd ltaotesrigInniftihceanatrltyicdiee,crtehaesescdietnhtyirsotlsdihncolrumdoenae lPeFvOelAs,exapnodstuhree asuttohpopresdrepo[rEtxtthraatctt]hyroid hormones became more norm after tShiamitlwarolryk,eirns 1w9i9t8h,h3igMh sbclioenotdisltesveplusbolfisPhFeOdAa hsatdudsytatthiastticianlcllyusdiegdniafitcaabnlteisnchroewaisensg. fininTdSinHg, ian mtheeassutrudeyosfuhmympaorthyy,roriedsuilstms or d[iEsxctursascito]n. Yseectt,iotnh.ey failed to discuss this `DcuoPmopnotunredcsenatflfyectprtehseentthyerdoidda,tabutto ItnhteerEpPrAetsehdotwhiensge tehfaftectthseiarsf"lnuoonr-oatdevloemresre cpihtyisnigoltohgisicdaaltareasspo"nCsoensf,i"deanntidalprBouvsiidneedssnoInsfpoecrimfaitciodent"alls of the thyroid effects, f3eMturs.ecIennetxlpyliucnadbelryt,oaomkoncgotmhperemhaennysihveealatshseesndspmoeinnttsofsttuhdeieedff,ectthseyofnePgFlOeActteodtthoe `asdsaemsasgethien tohtyhreoridstautdiaesl,la,ndevPeFnOtAhohuagshbePeFnCsfoaurendsotoclceaaurslye ihynpkoetdhtyorotihdyriosimdin monkeys. Immune system problems. sInysltaebmoraatnodryatstluedasitesiPnFeOtAypceasusoefscetlolxsictihtayttorefgouulratoergiamnmsuonretifsusnucetsioinn (t2.he+2,im37m.une rPeFcOeAnthsatsuldoynsgcibeenetnistksnloewanmteoddtahamtageexptohesuirmtemuosnPeFsOyAsteeamrl,ybIuntIifneatrhee mmoosrte hnoatrmdfaulmatghaenthine aIdmulmtuhnooed.syIsntetmh.isTshteudsyplseceienntainsdtstfhayimleuds,tobfoitnhd acridtoicsael ttohaitmdmiudne `faudnuclttihoono,dw;esrpeleaetnroapthrioepdhyamoocncugrraendimaatltsheexlpoowseesdt Idnostehetewsotemd.b and through early Iwnheirndeusstpreyc'isalliazteedstcealnlismcaalllsetdudByc,elelvsemryatduorseeatnedsttehdehnaprrmoedducteheanstpilbeoedni,eas cgrlitaincdal toinctohmebPaFtCinfgamidliys.easLeo.dgTehdebtehhyinmdusthgelabnrdeassetebmosnepaarntdicualbaorvlye stehnesihteiavrettion chhuemmaicnasl,s tahned gdleasntdropylabyasctaercirai,tivcailrursoelse,iannIdmmcuannicteyr,cmealln.ufAatcteuarsitngonTecePlFlCs cthhaetmirceaclog(nPiFzDeA) 000338 Environmental Working Group || PFCs and PFOA: A troubled class of chemicals used in ScotchGard, St... Page 7of 12 thceausaensimtahle:g"lTahndymtiocrtoitsasuweawyatso ntohte fpooiunntd wihnetrhee smcaijeonrtiitstysocfatnrenaoteldonragtse.r" fin1d3:1It In d[iEsxatrpapceta]r,Whiit lheasPFbOeAenhalisnkneodt tboeaetnrosphhoywonfttohecagulsaendthIen tahnyimmaulsstdoocsoemdplinettehley ``ewxopmobseadnodnltyhrdouurgihngeaardluyltlihfo,odat doses that cause no thymus effects in animals: 2Ind2iv1er9s9e5psaynmelpoofssicuimentoinsteasrliym-pIliifeesitmhmeusniegniIfmipcaacntcse,oaf icomnmsuennesussyssttaetmemdeanmtafgreoimn adervleyloIfpem:en"Lti,fed-ulroinnggcparpeancaittaylfoarndimemarulnyeporsetsnpaotnaslediesvdeeltoeprmmeinntedinemaarlmymainls" (39) `MeaxnpyosIurmemuoncocturosxiecarclhyeimnicliafles pr+.odInuctehemfoerteusseavnedrethorroulgonhge-laarsltyilnigfe,datmheagtehywmhuesnis tinyspteroufmetnhtyamlicindfaomstaegriengobtsheergvreodwwtihthanPdFOdeAvceoluolpdmleenatd otfo tpheerimmanmeunntedseycsrteemme.ntTsh.e in Immune function, resulting In higher risk for infection and disease, including `ISnesvteirtaultestinudSiwesedbeynsclioeonkteisdtsatInthleabesffaetctSstoofckPhFoOlAm oUnniviemrmsiutnyeacnedlltshIen Kdeatraoill.inTskhaey fstouudnidedth--aetlPgFhOtAIdneacllre--asIentdhtehtehnyummubseranofdesvpelreeyn"immun.e. cYelalnsguebtpoalp.ulaaltsioofnoutnhedy PmoFuOnAtdaampargopeedr iimmmmuunnee creellspfounncsteiotno,faorpehigenncolmse,nornefaesrrtehdetcoelalss were unable to immunosupression Arefceepwtoofr t(hpeereoffxeicstosmoefpProFlOiAfeorantiinmg mauctnievastiynsgtermecceepltlosra-raeipdhuaeotroPaPcAtRi3va)titohnatof a a`cmteidvieatmeescsheavenriaslmotinherrodteonxitcs etfhfaenctsInohfuPmFaOnAs,anWdhtehnatscIisetnhtiosutgshfteetod bPeFOaAmotroe.mice itnhewheiffcehcttsheoncatphaecitthyfyomrutshicesllmsercehmaanini,smrehinafsorbceienng gtehneetrieclaelvlayncreemoofvtehde,lmabaonryatoofry setxupdoiseusrfeosr thouPmFaOnAs., and heightening the concern for in utero and early life human Ibnlowoodrkceelrlss,(lienuccroecaysteeds)blood~_, lseuvgeglessotfinPgFOthAatarweoraksesorcsiaarteeduwnidtehrisntcrreesassferdowmhite infection or disease, consistent with a picture of poor immune function. Reproductive problems, birth defects. PPFFOOAA icsaumsoersedteoaxtich tIon fyeotuunsgesraatnsdaitndfaonstesstthhaant tdooandoutltafafneicmtalsusr.viFvoarleIxnatmhpele, parents. rMeupcrhodoufcttihoenEsPtAu'dsycpoanicderfnorfobry P3FOMA.stIenmtshifsrosmtutdhy,e ardeusullttsraotfs awe2r0e02dorsaetd with PunFtOilAtphreiiorrotfofsmpraitnignga,reduwreianngemdaattinagboauntd 3prweegenkasncoyf,iaen.dTthherooufgfshporuitnglawcetrateion wfuhretthheerrdoPsFeOdAwdietchrPeaFsOeAs afnerdtilailtly,owaesdwteollbraesedd.ecIindethIifsPwFaOyA, etxhpeosEuPrAeceaanrlsyeien life causes developmental toxicity. TheRraattsreepxrpoodsuecdtitoonPsFtOudAyInshtohweewdowmabsotfhtaetn PdiFeOdAaits wmeoarneintg oInttxho eyihoiugnchgesatnidmoaslse. gAlrsoou,paegvreenattehronuguhmbmearrtaolfiotyrgwaanss wnoetreafaffefcetcetdedinbayduPlFtOrAatisn aatdualntymdaolseerlaetvsel. ``eexxppoosseedd IdnuruitnegrofeattalthIfee.lowest PFOA dose compared with adult male rats not wInermealiencrraetasseedxpaotstehdeolnolwyesdturdionsge.adFuolutrhooordg,atnwwoelogrhgtasn wweerieghatlste(rIevderinaanddulktidney) dmeaclreesaesxepdobsoeddywtoeiPgFhOtAainndthheadwosmigbn;ifiacnainmtlaylsinicnrtehaissedgrloiuvepr,tekinddneedy,toanhdavseeminal `wmeeiagshutrseaonfdtdoxeiccrietyasaenddsopflteeennIwnediigchatt.e iOmrpgaarnedweoirgghatncfhuannctgieosn.are used as a gross `Aex1p9o8s2edstinudtyhespwoonmsobretdhabnyin3Madaulslotshhooowded. tIhnatthPisFOstAudIsy,morarbebittoxfiectutsoesrahbabidts csiagunsieficeafnftelcytsinocnretahseedmontuhemrb.er of skeletal abnormaiites a a dose that did not 000339 Environmental Working Group || PFCs and PFOA: A troubled classofchemicals used in ScotchGard, St... Page 8 of 12 DPaurPkoenrtsbturegs.tedTfhoercaonmdpfaonuyndfoPlFlOowAedinatnhdedbolcouodmoefnfteemdaplreegpnlaanntcywooruktecrosmiens In e1x9p7o5saenddwo1r9k8e1rsh.aTdwboirtohf sdeefveecntsc,hiolndereannb"ournnctoofnefmiarlemepyldae"ntawnodrkteearrsdbuecttwdeeefnect, arenadssoingeneadnionsttrhile aplnadnte.ye defect.{Full Document] In 1981 fifty women were Imnalaeddrietpironodtuoctciavuesisnygstteemst,iciunlcalrudtiunmgorisn,crPeaFsOeAd csaiuzeseosf tmhaentyesottehse,reepfifdeicdtsymoindetshe acanudsseesmminaamlmvaersiyctluesmor-,sanadnddeccerlelualsaerdefpfreocsttsatoen Itnheraovtarsy. In the female, PFOA BPeFgOiAnncianugseIsn 1te9s9t2i,cuDlaurPotnutmosrcsieantnidstostbheergahnartmofuplubelfifsehctpsapoenrsthaeddmraelsesirnegprhooduwctive tfroaucntd(tthhaety PhFavOeA nIontcrsetausdeisedblmoaodmmleavrelys goflaensdtraadnidolov(atrhieamnaejfofrecftso)r.mFiorfste,sttrhoegyen In hreugmulaantsiona,ndternoddienngtst)o idnecmraelaeseratbsl.ooTdhelyeveallssooffotuenstdotshtaetroPnFeOaAndafafletcetrs ttheestosterone. "plreosdiuocntiatonthoef tleevsetlosotfetrhoeneteisntteess"ticular cells , effects that are likely due to a AIncfroelalsoews-ulpevsetlusdyofpeusbtlrisohgeedn bbyy DinucProenatsisncgieancttiisvtistyInof1li9v9e5r sahroomwaetdasteh,ataPnFeOnAzyme tihnactrecaosnevderttesstticeusltaorstleevreolnseofto2esptrroatdeioiln. proBdiuecgeedlIenthail.ghallesvoelfsoubnydctahnacterPFcOelAls cnaoltlesdtutdriaendsffoermmailneg rgartsowatshoffatcetnoar-salmpahlae(rTaGtsF,a)oth.erWshtiuldeieDsuhPaovnet sschioewntnistthsathave estradiol stimulates excess release of TFG-a in mammary cells. `BceacuasuedsebyhiPgFhOlAe,veElsPAofseusgtgreosgteend atrheatatrhieskInfadcutcotriofnorofthLeeytdyipgeocfeltlesttuimcourlsa,r atutmyopre of teelsetviactuiloanr tofumeosrt,robgyenPFO(AExmtaryabcte| eFnudllocDroicnuemmeendti)ated, possibly by sustained `Ienxcproesaesded3MestwroardkieolrsanadatdepclraenatstehdattepsrtoodsutceerdonePFhOaAveInbCeoetntafgoeunGdroionvhei,ghMlNy. i1c moTrehrliekeelysttuodideise ionr tsweoek3trepaltanmtesnthafovreccaonncfeirrsmeofd tthheatmaelxeporseepdrowdourckteirvse atrpapcetar Next Page: PFCs in Water, Food, and Ar References: `SpeHnoclelro,weCllA, aJGn.d, BSrtaaevhelrimnagn,,NLWE..2F0l0a2n.deSres,ruWmD.T,SHH,anTn(o4)n,, aWnHd.,thGyurnotiedra,ntEiWb.o,dies iEnxatmhienUantiitoendSSutravteesy p(oNpHuAlaNtEiSon11()1.98J8Cltion 1E9n9d4o)c:riNnaotlioMneatlaHbe8a7l(t2h):an4d89N-u9t9r.ition repYroordku,ctRiGon(s2t0u02d)y.ofOraamlm(ognaviaugme)petrwfol-ugoernoeorcattainocnat(eon(eAPlFitOt)er Ipnerratgse.neRreaptoirotn) pNor.epTa-r6e88d9.f6o.r,3M,ReSvt.iePwaeudl,inMNUSbyEPAArgAuRs22R6e-s1e0a9r2c.h (Horsham, PA). Sponsors Study assEensvsimreonntmeonftpaelrfPlruootrecotoicotnanAogicenaccyid(aEnPAd).It20s0a2l.ts,RNeovivseemdbedrraf4t, h2a0z0a2r.d U.S. EPA Administrative Record AR226-1136. EdwRairedss,,LABKG., 2E0i0s2ne.r,SEMEP.R,CKaonscaerry,StCatLi,stHicasnkReeyv,ieBwF.,19M7i3l-e1r,99B9A.:, COlveergvgi,ewL ainnda Shiintgpl:e//PsOeFe.r.Ncaatnicoenra.lgCoavn/ceserr/I1n9s7t3it_u1t9e9.9/Bseetchteisodnas,hMtDml..Avalable online at perBflieugoerlo,doLcBt.a,noLaiut,e RoCn.,LeHyudritgt,ceMllEfaunncdtiCoono:k,inJvC.itr1o9,95in. viEvfof,ecatsndofeaxmvmivoonistuudmies. 000340 Environmental Working Group [| PFCs and PFOA: A troubled classofchemicals used in ScotchGard, St... Page 9 of I Toxicol Appl Pharmacol 134(1): 18:25. cel1Cloaodke,ioJCm.a,sMburyraaym,mSoMn.i,uFmrapmeref,luSoRroaonctdanHauarttte,: MaE.po1s9s9i2b.leIenndduocctriionne-orfeLleaytdeidg mechanism. Toxicol Appl Pharmacol 113(2); 209-17. prolLiif,eraRtCo.r,s Hoanhnr,atCLeaynddigHucretllt,fuMnEc.ti1o9n96In. viTthroe. dFiruenctdaefmfeAcptplofThoexpiactoilc3p0e(1r)o:xi1s0o2m-e 8 prolLiifue,raRtCo,r,, Haumrtmto,nMiEu,mCpoeorkf,luJoCroaoncdtaBnioeagtele,(CLBS.),1o9n96.hepEaftfiecctaorfotmhaetapseeroaxcitisvoimtey In adult male Crl:C BR (CD) rats. Fundam Appl Toxicol 30(2): 220-8. MecShieagneils,mLsB.o,f Heuxrttrta,heMEp.,aticFrtaummea,rSRI.n,dOuc'tCioonnnboyr,peJrCoxainsdomCeoopkr,olJfCe.ra2t0o0r1s. In male O rats. Toxicol Sc 60(1): 44-55. regisDturPyonno.t (31892957-)3.6-H1a.zaPrrdepcahrareadctbeyriLzBa.tioBniefgoerl,hSuemnainorhReeaslteharCc8h eTxoxpiocsoulrogeisCtA.S. JH. O1l9s9e8n.,"AGnW.e,piGdielmliloalnodg,icFDI.n,vBesutrilgeawt,ioMnM.of, rBeuprrroisd,ucJtMi.v,eMhaonrdemlo,neJs5 ainndmeMnanwdietlh, `2o2.ccuApsatoiorneavlieewxepdosIunreU.St.o pEePrAflAudomrionoicsttarnaotlicveaciRd.ecoJrOdcAcuRp22E6n-v1ir1o3n7 M(epdag4e0s(71)4:7-614145; POF pages 44-46), `AnswNeCrsI.(NAavtaiiolnaablleCaonnlcienre Iantsthitttupt:e/)/.ci2s0.0n0c.l nThe.stgiocvu/lfaarcCta/n6c_e3r4:.hQtume.stAicocnesssaendd January 16, 2003. fuorSoicbihnesmkiic,aLl.FC1-98174.3 T(wpoer-fYleuaorrooorcatlan(deieatm)mtooxniicutym/ccaarrcbionxoyglenaitcei)tiynsrtautsd.y Roefport 0p2re8p1aCrReOdDf1o2r;3M8,EHSQt.-1P0a8ul7,-0M3i9nn4e,soOtcatobbyerRi1k6e,r 1L9a8bo7raRteovriieewseIdnci.n SUtSudEyPANo."Revised Draft PFOA Hazard Assessment-Robust Study Annex" AR226-1137, p. 260-267. perfGulolraooncdt,anFoDlcanacdidMapnrdoedli,ctJiS.on 1p9l9a3n.t.MJorOtcacliutpy Maemdon3g5(9e)m:pl9o5y0e-e4s. ofa GrovAelefxacainlidtey.r,FBina(l20R0e1p).ortM.orDtiavliitsyonstoufdEynovfirwoonrmkeenrtsalemapnldoyOeccdupatattihoena3lMHCeoaltttha,ge `ESPcAhoAoldmoifniPsutbrlaitciHveealRtehc,orUndivAeRr2si2t6y-o1f13M7in(npeasgoeta,14A3p-r1il462;6,PO20F0p1a,gRee4v0i-e4w3e)d. In U.S. 3H. 2O0l0s1e.n, AGnW.e,piBduermlieowl,ogMiMc.a,naHloycskiisongf, eBp8i.s,oSdeksraotf,cJaCr.e, oBfur3rMis,DeJcMataunrdcMhaenmdiecla,l `aAngdenfciymAdpmliannitsetmrpatliovyeeeRse,co1r9d93A-R1299286.-1R1e3v7ie(wpeagdesin 1U5S6-E1n5v9i;roPnOmFenptaaglePr5o3t-e5c6t).ion 1996N.atAivoaniallabClaenocnelrinIensattitute (NCI). 1996. SEER Cancer Statistics Review. 1973 pswww. seerims.nl.nih.gov/Publications/CSR1973_1996/. 1997N.atAivoaniallabClaenocnelrinIensattitute (NCI). 1997. SEER Cancer Statistics Review. 1973Rp: /whew.seer.ims.ncl.nih.gov/Publications/CSR1973_1997/. PFODAuwPoonrtk.er1-9s78S.epPteersmobnearl 2a0n,d 1c9o7n8f.idential: Lab test summaries for Dupont R., KeBnutneendhoyf,f,G,J,Jr.CostLaie,deGr.,, PE.l,cOolmsbeen,, CG.,2FnadrrTahro,mDf.o,rdHa,nPs.en2,00K.2, . lTwoaxli,ciHt.y,oJfung, sAmMmoontnhi.umToPxeircfolluSocrioo6c9t(a1)n:oat2e44i-n2H57a.le AClysnoormeovligeuwsedMIonnUkeSyEsPaAftReervOireawleDdosIninUgSfor 5E.PA24"4R-e2v5i3s,ed Draft PFOA Hazard Assessment-Robust Study Annex" AR226+1137, reprDouduPcotnitonHasstkuedly:l LMaibxortautroeryo.f p2o0l0y(2c.ifDleuvoerloo-pmemtehnytlaelnea)n,daolnpeh-ag-efnleuroartoi-oonmega [2(mepthhoyslpehnaen)o,oxayl)pheat-hfyll]u-o,rom-oonmoegaamlm2o-(npihuamspshaolnto(oCxyA)S#et6hy5l5l3-0,-d7l1-a4m)m;onpoiluym(disaflituoro(CAS# 65530-72-5); poly(difluoromethylene), alpha, alpha'- (phosphinicobis(oxy- 000341 Environmental Working Group || PFCs and PFOA: A troubled classof chemicals used in ScotchGard, ... Page 10 of 12 2FE,r-ooertmohpeaynnsaalcdloynoPblrs(aC[cAoiSmoEeng6aA-7fv6u3eo.no0-e)],T3oandmumwoSanuirsuk(mCcsAsaSlSC(a7Cn7A3aS3lS-1A66c5.533(:0T-SU7CS0A-)3)Se;ction 8 aR EOmSeaT mrisi30op,na25Rg5eo5canapevdaprlmaoms aoo1n1te0o81cs0t3 ito 1n11e5s1i0.5m.BEM ASOY TERIA o(oDsmuepoemntaHnoaskneleSl:oLabCorAmathsorTy6. 5e2800r02.7eeS1ousb2c(hpv3oonohlecostexhrionctymonseyuiysm:eSnMeis)xtuhreao:f poly FPBolyeoinnaaaomre.a)(nomeho)ms,shaoSnoimoi,ntI S(CAvS4P3dR5O5o3Em8R7a6Ri.A3nS(SSoootnnr-(a.CpA1yG-lae$n5te3h5s0a(.n3CIe2A-Sed5S) a BRratceicnieanreAongmdenw5c3ay2r7T1oC0u3olgtSshusb2t70a35n/21c.3t1/0-C35o;n)teCSnrEtoU2m0eo(r0T3S-C1PAr5o0Ss7eh3caAte.ioynFeUSbtSreu)EamrSyiurb6omir3sm0se0in3ot.nal alae rin st ep wn 255 Gov/opp caaldo sub BeOS 30%Me DeOcupotnt. 200S2. 1The0updEatRedAcoipy onf DuePonRtePcroordduActRSS3tEewSa0r6d5s.hip on cRopyeDaLutpedoandtunnHoesekaenldyl SLaraboevrnaata-orray.loo20n02rL.EPRereosRuluptChsHaoSsfnoyannhorsral,SgaowvdahgelcosmbifnorerdPaO:9Y0-day `SGoormebgr3aE /a(62n0-h/Cy0ad1nrtoaSxylEeANtchGtyl1()0T9pS1oE El1y)1(9Sd5ei5cf.tluoeorrvo6em6ei)thoSaenueb)3m,ir(s31se0:i01n1o).n!(RtAeevtlaceoimacaeetrsdiiBoronmovoismnpnoeee7nteo1hnf5e;/r)0To1xe Nisan 650300opp ca) BERS101501 Mi: NovOeurnaan,8.2030025.8Du6pont uroAtaslomer producRtesstoerwaSrds3hip8up2date, presented GSlaudOloructtaeneHa(osCkAneSlSL3a5b.a7r0pa-t6er01yr.1s2.010S.23k..a5nR3ee:s3su4lM1t4s oeofca2h(wuCereAok-DLa)-llsoadiaanbuoteaxniecc(C1AoS aRgSenScoyoS:1,oTao33s.ee6SSs3uo3b53sd1t3ao5n/pEc5e2e:rSCloeSnsotrnao)hneDAncdt0n(eaTLSr(5C3cA78l)518sS,0.e.c3H)o.ynaGh2Eeo2ryd0ta0otS8n:uumobermvnsitscaaiohrdnoeRemeoccineovinedot Rp oven Gow535 des3 u]25 002/38 505.0) 53205 im ASvtalWoaonnoidy,onLCi.ne20o5f2.ipTLh6y6r.o1i3d9.S68t.a30t7s. TmheeTdhyroidUsFosundaptiono(ofeeAsmoeerdic 2008U"S EPA (2002). Dr hazard assessment of PFOA and is sls February 20, 5assLle,nRNt. rofsppr,oTdH,heHulrloey,cie.meRrosse.nthEanl,roStn.aHnedscShigBh,oOvV.e1S9o988,EiNkS47 acisteL,oim.e1r99s8, HroodeenotfscErcmnraepeHncecaienroopfbpeest1icoid6es In5du5cin.g thyroid 31,355O.adtMdaotwr,mdJl,EtyPraonllodmdaelf,icGiEem.ncAylndaunf,in0VgCp.rWWeianlarlnaecmyns,aSn3de.SuFKbansnieegahute,nJ9t,dGiagnnonR,e eee desaopmend of he Ge Er eh SAS: 45-55. ePonepT 2e,dKiuienpeeriss, ,JcL.snVvcaiani.cSaaOatro,rnsALci, nhVegrikeCrodkn,t.Vr,aedoverannanScoyn,1S5Hei9,s5dtCoeonrveidder, palpsoked phamotar devas Sane. Ci Endemol oun S02) SeurbrGseoedldhfeoernnt,snEHtB,eoJFmoeseupC,1oOa.bt,y GSnelueRhGPaoanmdsRHeehsvPeinagrr, 3ao5n.dc1D97ee8B.PNFTieeOtny.-daRyeport BoRON n ad(mrfteawnaneHNR) S3t0y N.o. 137-050. Reviewed i US EPA rte 000342 Environmental Working Group || PFCs and PFOA: A troubled classof chemicals used in ScotchGard, . Page 11 of I. uOpcolneYardneige;,taWQriy..eA2xb0pe02do.rsVuPaorlotueegnehtresdu,ppaMp.t,reXnstesp,aenYro,afixZsnhoamoea,dpXaYrp.oi,lieMeraslItlmoerr,, Gp.e,ufeeelsrspooonon,scet8ai0naioncde $6, i mmanopharmaco 25-37: 369.83, vImoilmYvuaennmgo,emanQd.tsXotfiaett,honY.pc,eaArulosewexsdsoobrnyi,epSepErr.aolnNlieeslrosamotnes,p-8aoc0lifuaeanrtdaetdDrasrlenceeerpt,eor.JWl.Bpo2sc00hn2etmhe Pharmacol 6310) 1853-500, an tYhaentg,hyQm.isXiaev,dYsnpedenDeopfmeircre,.JCWi.n2E00x0p.iEmfmfaecntestof15p5e0r5ox)i3s1o5m-e3p8r:olferators SevyidmYeianncoae,nfdQor.stphXiieee,IlvY.hi,vtEeolmsepontnIn,5GuAtiMe.nd,ibNyoeltnsnono,pfrcBeeDlnliaprnroadlmfDeeerPpalteriroornev,aenWrd.ade20v0e1l.opFmuernttheirn Derfuorectanae acid im mice. Biochem Phatmacol 6x8, 1135-46. {dreocmaGnetaohreegwae,oirHnEsearsnastdi.oAnnToadxneicrchsoelemnAicpMapEl,lPy1Ri9an8a6d.cuocT)eoSdx5is(c2te3fafeoctn1s6s9o.f0n5ot,nhaed19ed9ce6av,fellSuoapotirenomgne-nt Srmuaan: s8y07s8t.e th widife/numan connection: Enron Heath Sespect 104 5methL5oursdtase.r5,8M5Le,vaiDaetaen,deJvelaonpdmeGnetramlolmeoc,ncOtRo.n2i0c0h3r..CornseennsusHewoorlksPhoosppeonct 111 nVaenJCaoctob,s,Ew0,S.sDe20t03t. WLRa.boOrXaitoeryy,TOeK.s, GHaarndgb,ooUk.., HColrevvaetl,anR,d, OPerrsoLnes,-COoLmapn,d 3St1u4d1GyoCrontoCn.eirno,srEaabGIb,iTtBsL.DamSRp8erpeocrhtt,srepGaraendd fCoarse3,,WT5.. 1h9a82,. MOrIalbytekatorlogCyabSoturdsyroefs- Footnotes for informational graphic 4De0cprepabse(d1 gmraon/tkno:/day) D1e2c0repvpsbed(3drmogw/kngd/edcaryes)sed ptutary size (females); decreased breastfeeding; 3Be7c0rEpvpibed(1r0omgw/kGge/edr)ensed piutary size (females); fc GBi1nue,cct0rr0hee0;anspedsdpedcbnprue(hma3obs0teeadmrngoo/frskotegwere/ehtdm)ydaecliya)ytee;ds sdfeeaxcmuraleles)sma;adtudHreaictrnieoesnsae(dmsablrreeesasmatonfdteecfoemmaal:e); toxicCihtaynagnedsoifnteonrgraenlescikzedaarmeaogfetdenoruosaend bfuynsccioennts to Is a crude measure of Gased an adult lactating female rats 3 weeksafter ging birth suemr| bEufemercetvosfesesfefeoenfctPIsnFtaOeduntlthnamtnahlSeeASrUautfsteemxmaptlosseasdtpiraihutndegro.c15oAudmnupclltaemarraltIfeo (trhaeetssmhtaaleveesphairgehnetr Raver exposed in aero I doe o ear ne 000343 Environmental Working Group | PFCs and PFOA: A troubled classof chemicals used in ScotchGard, . Page 12of12 Nppobt)e: Control rats had blood PFOA levels below the level of quantitation (5.3 Back to top Next Page: PFCs in Water, Food.andAl. hig infogens org 000344 Environmental Working Group || PFCs and PFOA: A troubled classof chemicals used in ScotchGard, St... Page 1 of 5 PFCs `GLOBAL CONTAMINANTS wm, STAINVIASTER "amnme 7 Sa H3 2: In Pople Everywhere pyre -- PFOA pollutes air, drinking water, and food i two pl sds sins fund PFOA tp water, utdor eens air, green beans, apples, bread, and ground beef, from ear Bl tTable.oYOmannd i ctsypreSnchuyrtsoee rsi.have been found as | oi "intsSpinAbout PFOR -- EE -- -- J r veitor ry Gps > orc onan | | -- 2 =. | (Kroger, |e) Secmenvatosnnse|s| doectes | Gfvoovsern, sowoer.s|| tmtotes | (pvSA oekraamnen I i neactive Mapof PFC Pollution |oemcweere | Em] rvo,wan fSoaymsper | rodeeces Soe de pre gne pemrssscas W eod t TARTEa wosriep ws=ega Concamuat0o.0n55.osr. Cons erswemroree | Ereome nmennrms | porest. ee | | See | =Geese. = we Ty ove (Production = (Feral |W Miheete Lake Givaossee | VW Yer| VY v | Fwres v =cforhmaree v v w_o--rsens |W] Gen G5vlhue | V v 000345 Environmental Working Group [| PFCs and PFOA: A troubled classofchemicals used in ScotchGard, St... Page 2 of3 -- -- as S eERnAe Si ere n a ee | [ER rl FEOSNSI n+mr i1, sSeuerte ESuhn ot rPotOmsepTrAcTaveObunsScoOrMreE0TyyYaSs ESa EERSSIE aInlChaTrh,| S Bob, ini a loaafod oaf brepao defsromn LPenIsacEola, Be Florida at fOB CpoooRsnseeinbplperiaisnommuaarryciyefsferooofmmPoFcOonsnAsuT Iumnmeheiruromrpuaronnodadubrulcco,so,d,.bubuCtgturcsrcoeuonlutedlsB PhfdFoesOsAnStbtoeecdmymrfA ebrouomrmdwseecneexsp1emo9iss9guhtrtteosoes TroOnsMA eens I BT H eSSSM Pr SeaE rIDiLLn Ei. on in 00%, testes oo fon spermine, ner ind TE en cE omecloe nseern kFslslim, eu EC fnrnwae sore, I sry cy. To rt ry wt iin bd Wr EJ So neemaanroao:nEgcTetmabnh1s012o300r5 te JSB uebrmi3tt'esd Sdcaotatce shL hgoawridnpghaPsEdCocuotntaanmnionuaL ntcieonmernntoFoirnsMaanyd2m 0k0e0s).,Tsa hoemecoumspl eadnay6 ER nd Cons Se PFOA in Wastewater and Landfills. `Bclemisesfound PFOA I every sample bn evry chy Eta a ee wassemoveponds EE EE NeLinCOLS IIpRes aging 16m 6.975 < 0:34 pk, Columbus, Georgia Ci ore eyr ber ako pela ,desiri edeuneandasntre As with the human blood studies, and then the wildlife studies, 3M again found PFCS where they were not expected. 3M designed the study to Include three cities reofoet prasad at perma sccies thr fied E eSe d emitJ r aoE s ell ,pr or on t, widespread environmental contamination. In analyses of beef, pork, chicken, hot IB nn sIamer Va rs oT fnts SsrTsoounnadFPeEOONasmrSTaOhewmB iniatElE a I Ia aepl e i pS ronsoma 0 Tap Water Contamination from DuPont's Plants 000346 Environmental Working Group || PFCs and PFOA: A troubled class of chemicals used in ScotchGard, St... Page 3 of3 f`ooOtvperrintth.e" years, DuPont has worked hard to reduce is chemical --Dupont, in reference to C-8 water levels in Little Hocking, OH (<1 iDnutPeornnatl fsitnuddsiepserovfatsaipvewactoenrtaImnin1a9t8i4onInatrhoeunvdiciitnsitmyaonfufthaecltrurWiansghifnagcitloitnesW.oTrnks Tnef2losntoPrleanttapinInWeLsutBeVcikr,giWnieas,tDVuiProginntiad,eattecctoendcePnFtOraAtiatoncsonocfe1n.t0raatnidon1s.2ofp1p.b5 ipnpba. sHtoocrkeintga,p WinesWtasVhiirgnigntioa.n,(EWxVt,racatn]dMaatncyoonfctenhtersaeticoonnscoefnt0r.a8tiaonnds 0a.r6e phpigbheInr Ltihtatlne tthheosreesdiedteencttsednoIrn satnadtieilrelgeualcahtaotres IanboPuotrttShte. tLeusctiien,g Folrortidhae. reDsuuPltosn.t told neither WHohcekningf'orscwedatbeyr tInhe20s0ta2t,e tthoeccoondmupcatnya mfoourned tthhoartoluegvhelisnovfesPtFigOaAtiIonn tohfeittowen's psairlgotndhiuofcuitcgaihnotnDluywPeholinlgstherhraantsgheradencefDnrutoPlmoyn0at.'r4sg9ul5eodtn0gf-8os.tar5a8nmdpuipncbg.hIhnitegTrhnheaerlssseaaffceeottnyycessntttaarnnaddtaairroddnstohfarro1eupgphb, tbhuet awuhsipcihceisncolfudaesdrDiunPkionngtweamtpelroayseseessasnmdencthetmeairsmtrlyedinbdyusWtersytcoVnisruglitnainatrse.gulators How do these chemicals get into our food, water, and landfill leachate? EainrvainrdonwmateenrtaplollRuetlieonasferso.m BDeucPaounsteaIndis 3uMnrpelgaunltasteidn,WPesFtOAViIrsgilneigaa,llyNorretlheased as. CinarNoolritnah,GMeoirngnieas,otNaoratnhdCAalroalbianmaa,;anadndotfhreormpclaarcpese.t, clothing, and paper industries `DWuePsotnVtiregsitniamaatnedd i(tnsaCthea4m)btehrast tWwoorkosf kfasciplltayntisn,NietswWJaesrhsieny,gtroenleWaosredksa pcloamntbiinned tloatnadlfiolfs2I0n t19o9n9s. of3PMFeOsAtiimnattoetsheloawie,r 3r3el0e0asteosnsfonrttostfhaeciwliatteesr: ainnd19t9h7reIetstoCnosttIangteo GtroovPeFMCipnlnaenatpsalwiesreprordeulcetaisoend apblaonutt r2e3l0ea0setdon3s toofnPsFiOnAtoitnhtoe tahire, wwahtielre.1in 1999, `sTuhrerioumnmdeidnigatPeFCrepslualnttso.f tIhnetsheeesnuvrifraocnemweanttearl Irmemleeadsieasteclayn dboewsnesetnreinamthoefa3r'eass DecIantuWresptlanVti,rgicnoinac,enptrroadtuicotnisonofwePlFlOsAthwaetruesfeodutnodstuoppbley1d9r0in0kipnpgbwaantder1t0o24 ppb. `hDiugPhonats's[1W.a9sphpibn]gtoofnPFWOoAr,ksanpdlawntelhlavaet blaenednilmeaansdudriegdesttoiohnavpeoncdonacreenatsrahtaivones as reached levels as high as 13,600 ppb. Fdolmuionraonttelsoomuerrces oAflcPoFhOoAlsi.n hFluumoarnotbellooomde.r Tahlrcoohuoglhs mlaabyortautronryousttutdoiebseItnhdeu.stry secniveintriosntmsehnatvaenkdnionwtnhesibnocdey1t9o81PFtOhAatafnlduoProFtOeAl-oImkeer aclocmophooulnsdbsr.ea(knodtoewn2) In10t. he [foBurnedakidnoswuncShtusedeymi|ngElxtyraicntn|ocFuuloluDsopcruomdeucntts]aTshheaflsuohraomtpelooomearndalccoonhdoiltsioanreer, pfoarpebircypcrloedsu,cgtasrpdreenpatoroeldsfoarnddirzeicpptercso.ntact with food, rug cleaners, and lubricants A"ClotnhfoiudgehntilaarlgBeusseicnteisosnsInoffotrhmeatdioonc,u"me3nrtecheanvteDbuePeonntreTmeolvoemde,r uPnredseerntcaltaiiomns oInf EPA's fle clearly expressed DuPont's concern over the fluprotelomers: W"eWeaarreecconofmimdietnttetdhatto oaunrdpsrtoadyuicntgsinartehseabfuesifnoerssth.eir intended uses." ~ Dupont Product Stewardship Update, 17 DEC 2001. [Excerpt] Next Page: PECisn Animals. 000347 Environmental Working Group || PFCs and PFOA: A troubled class of chemicals used in ScotchGard, St... Page 4 of References Ass3eMs.sm1e9n9t9.MuQlutail-iCtiytyAsSsaumrpalnicneg PTraosjke.ctU.PSl.anEPfoAr AEdmmpiirniicsatlraHtiuvmeaRnecEoxrpdosAuRr2e260952. wat3erM,. s2l0u0d1g.e,Esxeecduitmievnet,SuPmOmTaWrye:fflEunevntiraonndmelnatnadlfilmolneiatcohraitnegs-ammpulletsi-.ctU.yS.stuEdPyA. Admiristrative Record AR226-1030a111. FOSUAS, EannvdirPoFnOmAenftraolmPrvoatreicotuisofnoAogdemnactyri(cUeSs EuPsiAn)g(H2P00L1C).elAencatlryossipsraoyf/mPaFsOsS', Spectrometry, 3M study conducted by Centre Analytical Laboratories, Inc. MabMuarryt,in$,AJ.W.2,00M2u.irC,olDlCe.c,tiMoonoofday,irCbAo.r,nEellyso,rDiAn.a,teKdwaonr,gaWnCi.c,s aSnodloamnoanl,ysKisRbayndgas. 0ch.romatography/chemical ionization mass spectrometry. Anal Chem 74(3): 584- httDpu:P/o/nwtw.w.2c0B0.2n.focr8mI.ncfoomr/md.wwav/apillaabnltesko2nl0icnoemmatunications/22103.html. AssAoscsioactiiaotniosnu,mmLaHrWi.zi2n0g02.resCuoltpsieosf Cof-8PrleesvselRseilneaOsheiso fcroommmuLinttilteyHowcaktienrgsuWpaptleires (sampling rounds 1-7). U.S. EPA Administrative Record AR226-1157. 2002U.S EPA (2002). Draft hazard assessment of PFOA and its salts February 20, Env3iMr.on2m0e0n1t.alSePlreocttecetdioFnluAogreocnhceymiAcdamlisniisntrtahteiDveecRaetcuor,rdAlNaubmabmearAArRe2a,26U-S 1030a161 Pla"nTtafta.nd20L0an2d.fiCllosm.piUl.aS.tioEnPAofAHdimsitnoirsictarlatCi-v8e DRaetcaorDduAPRo2nt26W-a1s1h9i4n.gton Works Main `StudSyerfvoirceBsi,odPeA.gra2d00a2t.ionBiSocdreegernadSattuidoyn fSotruTdeylRoempeorrtT:ypBeioAdlecgorhaodlast.ioUn.SS.crEePeAn `Administrative Record AR226-1149. CharHacatgeerni,zaDtFi.o,noBeflifsllue,orJi.n,atJeodhnmseotna,boJlOitaensdbVyaenkgaatsescwharrolmua,toP.gr1a9p8h1ic-helium mpeircfriouwoaravdeecpalnaoslmatodpeetrefcltuoorr-otohcteabniooatter.anAsnfaolrmBaitoiocnheomf 1H, 1H, 118(2): 2H, 2H336-43. AR22D6u-P1o0n4t2..2001. DuPont Telomer Presentation. U.S. EPA Administrative Record Next Page: PFCs in Animals. Notes releaseEsPoCfRoAnlSyecatbioount361530rdeiqfufierreesntmcahneumfiaccatlusr,erasndtoPrFeOpAorIts ennovtiornoenmoefntthaelm. `hTthtespe:/ch/ewm.icsaclosreccaanrdb.eofrgo/ugnednoenratlhteriTtRrIi_(cThoeximchstRmle,lease Inventory List). generalAfsourbmsuelqauCenFt3(sCtuFd2y)nspCoHn2sCoHr2e0dHbywil3lMbiroedpeogrrtaeddethtoatpfelrufoluroortienlaotmeedrsacoifdtshaelts ofthe general formula CF3(CF2)nCO2- and CF(CF2)(n-1)CO2-. 000348 Environmental Working Group | PFCs and PFOA: A troubled classofchemicals used in ScotchGard, St... Page 5 of LT LAA infogens.rs roma Scotchgards 000349 Environmental Working Group || PFCs and PFOA:A troubled classofchemicals used in ScotchGard, St... Page 1 of PFCs GLOBAL CONTAMINANTS STAINVASTER TT ~~ Waduation ra re - -- oo . PFCs In Animals Worldwide ERS FET en and processes, PFOA has dispersed around the globe, and now contaminates In15studies conducted since 1994 scientists have found 4`wocrolndt-iinnen1t6sowfh7e7respaecniiemsa,lsinh6avoef b1e2ecnoutnetsrtieeds and on [Widiife 3 of the study | orndea sone ots om eon a is eguiotory Gaps = PFC polls Caspian seals; andin ashort-snouted spinner dolphinoff the coast of Florida To Bh TT | scractrce Map of PFCPollution TT shoersGudetorrcs stYipeoaessr [ge Country craven] a -slNumber|| PFOA fvoounsd| | afiohs Species | Range (ppb) smn| rz `Searchable database: PFC documents: See---------- Thunder Bay,| He 20f3|| er ring-billed f| <180 oest 000350 Environmental Working Group || PFCs and PFOA: A a troubled class of | Tomluys e chemicals used in ScotchGard, St... Page 2 of! pFewor10510B2rnnm| |BmmpnA=eemep]e e]|,|BRreeorn]|Epae pmE| el =EE E ssemee||E E | E|m=mn) TeaT|a 5 ] = = TCoTeeTTodeww==iord i]m =eT e TE =are|e] RT Ee[fa|esr [on] CARTEBlacw=Ck-ce aorede] E I SE A S epeme eE E oE m E E aon E EHEE m n a 000351 Environmental Working Group || PFCs and PFOA: A troubled classof chemicals used in ScotchGard, St... Page 3 of5 5CFoa0mtSeinrwgassaodrheattetrcteea,dsiFnshaloofafntgthheBeriwrSdisdlloyfemoFspt3ehce5ieBTsatoaiencaalCynzaeidon:oidsaesatsnmemained Feahanarean ses 3aS'nosyneePvsicdsennmcReeOoRof gahlnod1b5aP8lR05Oc,oSnStfHoarmFeiaxnmaametpdiloehna-nkwtitohmeobk1e9b)8r0rescs,oTokhdwronowusghpnrsteouddiuecs of heoemamaeGrsha.ottoTbnaaoesuysnbMytbabpraasaseresrduosbwnaenn1sc(oShvooedrmeeadsnaAgoahtreoonauscgalhndmetesrocuchghaccnhhabemyimeWlh enleo awlatetrh hyrdorvoe.s Ton a ei FH re compte TrChoornosuaganh.itnSehhsaemtaaursenhsetrthhttTshdoeemssefnsPcspascr,aamvecetoemreikipeedevtwaieplorrcphrereadsvseuerglerlaaonnddgaHAeptnornys'cses BSmoseor ohme cammeaCrha PeEcChoaevseaneaernoamrecaomnerfor ceca to roma oEGvrreiantthoherouygnh a1el99td0h4e 6bP1aE6sOSk81dca6otna5tawhmrieenactIhnieoirnyabcofstgoasnnaihscotcnokentuapmgilpnoiabtasilohrna.atbIhlwee1r,9e9n7pootthneglr SBEEaenasdasOoCuoekhdpaahtiSecoedmsesthsesaP9nhOsSScaiSfosocfnawrietdesspawrneedtnht5e1or0nb0lt3na.roFritdtoneerorfsHaoomoadmnthe iorSaileWoHf wAietatcsamCaomnitneatInoHnedoon Wisconsin os 5 rot pm deiing e 3oMrmdaefninih0ti3eve awiSrledse sotTfue5dip0eesSsinPetrheesnaStovemeb1rry9e9e0ae,tle3sansmtpaloebFmfoousrndowPhnesheenan, SCFooouumtlee,satFoeCitdrtaeeo1,mmea5n4adHSGh,tSe.esaaidanndPsr0Toh8esr5c3DeroaecemdaaDtteHreoocrnhatceeodnmHp1et,OenoSfAttomosnodCetaSileBedrooiwrnhndeuPda6eldehoe i mi aro, "It's everywhere." -- Teflon World website IrinoncsodntiSraaemstps,letmsheweaarseoPuocnsmd aPtrElCaesvkienes2,B0MpreroGcnrenostu(a3)n1d0ofBe1ew5asnHaesnodkkhioln,copradnoeoIftvJ5ekrs one of eaNeromraTsiokeanaraenye.sshPoTrheeashdneatecrndtnsFsChhrotonblIessoCanr5TtonoaoadrpehOdvDTse,pehcheiseeeycocrthreeemliactaellsth Concameme In Toh wi he ponent ul up ne food hai ECOovEmearucacaifroodnuras-tdaaiyoapntrbodeabslegoifnSiwhnigSltaeernectsso1st5ed1e9e9dn9,efo3dFsOeSTnovdainrrdoensmueonttsael BpleoabcuosnrdaistoorFy CBConeotaeeminnoaftspironac,hlaSogcroeenaatsdmcraoommuaswwsorrerknebsrasecskoswfatwrhhdeastUts5a.SAc1o2tecsnrpbrdohdaonmdwefiroenhtfeoPuFnC to ra] eT3hrsfoooCuodnnd,tPaOEmnCisneailtnedaywviSneorPccFapoSfeosStxtlPeeovssetslSeadwn.ieisenhgsetaiarnsgh aSHolaertst33hhpootrhthadpaenrrebviTelroafnhlonwn TEChrieenanwnaatseortashsaramomuinadcsaBVesoaynaGsgoeCeuorvses,nNSaotaivonenaRelivPeaFrske.Farlulis,esnBe,keaarncedy fCorhosamnSahta:evveoessShICoawanumltnask Croimmoeeyolks 3wlComtareoanssaomraCnoSminodreess.wnsaPvEeCsFl Choemtptrea tak 000352 Environmental Working Group || PFCs and PFOA: A troubled classofchemicals used in ScotchGard, St... Page 4of 5 PFCs contaminate people and wildlife on a global level. Ilinveera,rlkyid2ne0y0,0asncidenbtliosotds fsraommplMeischfirgoamn 1S5tastpeecUineisveorfsimtayrcionmepmleatmedmatels-stinIgnc2l4ud7ing. p`oClaanradbae,arAsl,asskeaan lciooanss,tasleawlast,earsn,d Fwlhoarildeas, aconldleCcatleidfofrrnoiam.tPhFeOAArcwtiacs, fSaobulned Iisnl1an7d in `pceormcpelnetteofptehrevassaimvpelneesssteosftPedF,C bcuotnttahmeinfaitndiionng.sTfhore PaFuOthSorpsoionftetdhetoneawnemaarrliy.ne. `Armcatmicmawlatsetrusdsyucgognecsltusdewdi:de"sTphreeaodccgulrorbeanlcdeisotfriPbFuOtiSoninofmaPrFiOnSe Imnaclmumdianlgsrefmroomtethe locations. 51. ASlclotthcehgwailrddlicfheesmtiucdailesPcFoOnSduhcatsedacthoiedvaetde tihnedigcraeteattehsattdoifsttrhiebuPtiFoCns atnedstetdh,e 3hMi'gshest `ccoonncceennttrraattiioonnss Ianbowivleditfeh.osSecifeonutnidstisn hpalvaentdweotrekcetresd.PIFnOfSouIrn Cwialsdpilifaenattern eggs in Mic, haingdantelsatbsoafnanliynseesmisnhkosweIdn SaonutahveCraargoeliwnhaoslheoewgegd caonncaevnetrraatgieonlivoefr 2605 ppb c`cAoolnnaccbeeannmttarr,aattwiiohonnosoafovf2ef0ri8avge5ecpdelplb19op7.e0rTaphteposrbes .ilnev3el'ssarPeEChimgahneurftahcatnurwihnogleplbalntooidn Decatur, PenFvOiSrohnamsebnetesnondeetaerctthe.dItinhtahsebmeoesntdpertoetcetcetdedinsApleacsikesananpodlIanr tbheearmso(sitn p1r7isotfin1e7 btaelsdteedagpolleanrebsetalrisn,gsatyoaunngaevrertahgaen l7i0verdacyonscoelndtr(aitni3on3 onfes3t5li0ngpspba)i:l:0u/n,deMrid7w0esdtayesr.n folrdo,mwSitwhananLaavkeerNaagteiobnlaolodWiplldaisfemaRecfoungceenitnraStuimonneorf,3M3i0sspopubr)i-(i,vaergrceoantceengtrreattion oItfal1y71(dpetpebct)e,d ibnot4tolfen4osbeodtotllpehnionsse fdorlopmhitnhse, Awdirtihataicn SaevaeroafgfethbelocoodasctonocfeRnitcrcaltoinoen, Mofid1w4a3ypAptbo)ll (-d, eatnedctLeadysinan6oaflb6atarlobsastersosfsreosm, SaavnedraIgselabnldo,oad cwiolndceInifterarteifoungeofin16 PPO) `PaFcOroSsAs,tahecghleombiec.alOfpfroefcutrhseorItoafllPanFOcSo,astis, dPeFteOcStAed(aaltsosikgnniofwicnanatslFevOeSlAs)Inhsapsecbieese.n d`Sewtoercdtfeidshin(daetDeecitpehdiniuns7Wohaf7lesw(oirvdefrischo,ncaevnetrraatgieonblwoaods c8o7n8cepnptbr)ation+, and was in 7 ppb) Next Page: DuPont's spin about risks. References: in wGiiledisfye,. JEPnavnidronKaSncniaTne,chK.no2l00315.(7)G:lob1a3l39d-i4st2r.ibution of perfluorooctane sulfonate of pGelrefsiyu,oJrPooacntadneKsaunlnfaonn,atKe. a2n0d01r.el3atedCfolmupoaroncyhesmuibcmailsttiendfirsehpotrits:sueAsc.cuUm.uSl.atEiPoAn Administrative Record AR226-1030a, envGiireosnym,enJtP.anEdnvKiaronnnaSnc,i TKe.c2h0n0o2l. 3P6(e7r)f:luo1r4o6ch-e1m5ic2a.l surfactants In the FluGolreoscyheJmPi,caKKl.s i2n00M1i.nkAcacnudmuRlivaetrioOntteorfs.PerUf.lSu.orEoPoActAadnmeisnuilsftornaattieveanRdecroerldatAeRd22610302157. FisGhl-EeastyinJgP,WKaKt.er20B0i1rd.s,PeArRf2l2uo6r-o1o0c3t0an2e1s5u9l.foUn.aSt.e EanPdA ARdemliantiesdtFrlautoirveocRheecmoircadls in AR226-10303159. FluGolreoscyheJmpi,caKlK.s i2n00M1a.riAncecMuamumlmaatliso.n Uo.fS.PerEfPlAuAodrmoioncitsatnreastuilvoenaRteecoarndd ArRel2a2t6e~d 10302160. FluGoireoscyheJmpi,caKlKs. i2n00F1i.shATcicsusumeusl.atUiSonEnovfiPreornfmleunotraolocPtraonteescutlifoonnaAtgeenacnyd Related `Administrative Record Number AR226-10302156. 000353 Environmental Working Group || PFCs and PFOA: A troubled class of chemicals used in ScotchGard, St... Page 5 of5 + 3p. Kannan, K., Franson, JC., Bowerman, WW., Hansen, 2001. Perfiuorooctane sulfonate in fish-eating water bK3i.r,dsJoInnecsl,udPinDg abnadldGesy, `eagies and albatrosses. Environ Sci Technol 35(15): 3065-70. JoneKsa,nnPaDn.,, KH.e,llKe,oiEs.t,inNeyn,maJn,,BMecaknmdenG,leKs.y,, EJvPa.n2s0,01T.., AGcocruzemlualnayt,ioJnF.,ofHansen, K)., 5perfivorooctane sulfonate in marine mammals. Environ Sci Technol 35(8): 1593- 2002K,anPnearnf,luKo.r,soCcotrasonleisnuil,foS.n,atFeaalannddyrsezl,atJe,d fOleuhormien,atGe.d,hFyodcraorcdia,rbSonasndinGmleasryi,neJP. EmnavmimraolnsS,cifTieshcehsn,olan3d6(b1i5r)d:s f3r2o1m0-c6o.asts of the Baltic and the Mediterranean Seas. PerfKlaunornoaonc,taKn.,sNueifwosntaetde,aJn.,d Hraellbartoeodkf,luRoSriannatdedGlheysdyr,oJcPa.rb20o0n2s.in mink and river otters from the United States. Environ Sci Technol 36(12): 2566-71. 2002K.anCnoannc,enKt.r,atCihooln,s JofWp.erIfsleukio,riNn.a,teSdenatchiidslkiunmalirv,erKs.,ofKbiimr,dsDfHraomndJaGpieasny,anJPd. Korea. Chemosphere 49(3): 225-31. sulfKoanantneanI,n oKy.s,tHerasn,seCnra,sKsJo.s,trWeaadev,irgTiLniacan,dfGrioemsyt,heJP.Gu2I0f02o.f MPeexrifclouoarnodoctthae.ne Chesapeake Bay, USA. Arch Environ Contam Toxicol 42(3): 313-8. Admi3niMs.tr1a9t9i8.ve SRcerceoerndinAgR2o2f6P-F0O0BSO.levels In eagles and albatross. U.S. EPA for 33MM, LSta.boPraautlo,ryMNrebpoyrt3MofEfnlvuiorrooncmheenmtiaclalLsaibnorwialtdorbyirFdluloivreirnse, ARneaployrtitcpalrepared `Chemistry Team (FACT). Study No. FACT-TOX-010. Perf3iMv.or2o0o0c1t.anoSiccreAceindin(gPFSOtAu)d.ieUs.Si.n tEhPeAAAqdumeionuisstrPahtoitovleytRieccoDredgrAaRd2at2i6o-n10of30 Photolysis E00-2192. Admi3niMs.tr2a0t01i.ve HRyedcroorlydsAisR2R2e6a-c1ti0o3n0sa0of90P.erfluorooctanolc Acid (PFOA). U.S. EPA Admi3n1is.tr2a00t0i.ve BRieocdoergdraNduatmiboenrsAtRud2y26o-f0P0F5O7S., US Environmental Protection Agency. Admi`nCiosmtpraatniyv,e MR.ec1o9r7d6.ARB2i2o6d-e0g3r5a6da.tion Studies of Fluarocarbons. U.S. EPA perf3iMu.oro1o97c8t.aneTshuelf1o8n-yDla-ByasAeedroCbhiecmiBsitordieegs.radUa.tS.ionEPSAtuAddymionfistrative Record AR226-1030a. 2001O.lsDeenscGrWip,tiLvPe, SSuimmpmsaornyCoAf,BSuerrruims JFlMu,orBoucrhleerwicHaMlM,LLevuenldsbearmgonJKg, EMmapnldoelyeJeH. PParrotgircaimpa.ntFsinoafl tRheepoYretarEp2i0d0e0miDoelcoagyt,ur2F2l0u-o3rWo-c0h5e.micUa.lS.MeEdPiAcaAldmSiunrivsetirlaltainvcee Record AR226-10302120a. 92, <vivamicn: info@ena org 000354 Environmental Working Group | PFCs and PFOA: A troubled class of chemicals used in ScotchGard, St... Page 1 of 14 LSE AL TRAE Er PFCs GLOBAL CONTAMINANTS -- rctsten TTT ee eT L eos EveE rts Co ot Foren 8 Keath : Concerns EEin nine z Work ions pans 1 Bins S-- . Foguiators Ga- PEC Polto_n ser a i --hs---- ne i aiI uto -- -- Stompers Guide 0 7s -- em S-- earcha-- bie databat se: PCr documa ents LL part 7: DuPont's Spin About PFOA tDruoPuobnlteifsorinthbeigcormepgualnayt.orIyntrroeusbploensate Et7oA.IncArnedasitnhga,t cuonufladvomreabalne bpirgesescorenpoomritcs lDperucepasonentnttcohanachslurumseipaoennastheeddarllaytwhmniasbdkye.tTchhleiasiUmSpsuEtbPhiaAct,rewexilptaothisdounarstessspptuioblP1siFscOhlAee,adrolIyn Cpo6eu,etrdo-foresnvtoietpewveidth JSoluormnailns,dantod EwPiAt,h wdhaitachemEbWeGddheasd rIonv5i0e,w0e0d0apnadgepossotfedInidnussteryarscphoabnlseorfeodrmsotnuldiinees {click forsearchable database). aInnaslyusmimsaorfyc,uhrreernetisscDieunPtoinftic'sknsopwilneodngeP:FOA's health risks and EWG's 1. DaurPeotnootalsoswerttosbethaathelaevletlhsorifskP,FTOhAs fcoonucnldusiinonhiusmcaonntrbaldoicotded bsTteyuvdriyeo.cwe"AnfottfefrPinFsdOeieAnigtnsogfdtrehoitmsersamtnuidinygn,dwuthhseertyEh-ePsrApoeIxnipsteasdrtieetderdaar"erpgreuipolrraoitdtouyrcytion hacetioTnoxaigcaiSnusbtsttahnecceosmCpoonturnodl A5cwa(rTrSaCnAt)edduuendteorcSoenccteironns4t1h)atof ethfeecctosmIpnoaunnimdalcsa,usTehseamdovesrtsreecdeenvtelsotpempeInntaElPAa'nSdprreiporroydurcetviiveew w15:omdernafatnidkgiarsssaersesmdeanntgetrhoautslsyhocwossebltooodblloeovdellsevoeflPs FoOfAPFinOA that cause serious harm ta aboretory animals. 2. dDeumPoonnsttcrlaatimesstPhFeOrAe ciasunsoesevaiddveenrcseeohrudmaatna thheaatlth effects. oDmneuapwsoaunrrtkiehnrgasverexarppaoerstenedydtmooelPyFeOavAne,esahneudalntthchisswtseutrdueydyisnwitahsgelnpiumibitlneid rteocord S`itenuxcdprioeesasusresedpsonanrsweoorsreikgdenribsfy.ic3aMnMotrlsyehmtoorworiunebgllietkhseaoltymewtooardrkleeerfosifnwdpiirntoghssthaitgehfrcomPaFncOeAr a3nHdfcoeurnedbrtohvaatsecuxlpaorseddisweaosrek.erAsnoatrheesrigPniFfiOcansttluydymasrpeonesolryedtboy IbSiealeakmrycmatarrteaicoftonra.pnrdIonstpteaarntpcrereectaaitnnigccatdrhi,seosgraedsestrrtsou,idniateenssdtisiuncraimlnparirayccakbtlleaeddsdieobnresc,ause nthuemybearlshaofvepesoipglnei.ficSatnlt,dceasnicgenrfalanwdsoatnhderacrlcsbcoasseedreolnatsimoanlslhips aarnedfnoulnadb,oarantdortyhestcuodniseisst5entcryionfgh.ealth sffects amang workers 3. dDeuvPeolnotpmdeenniteasl tthoxaitciPtFyO.AEPcAa'suspersiorieyprroedviuecwtiovfePoFrOA was rineigiaartdeidngprtehceisdeelvyedluoepmteonctoanlcaenrndsrrepareodducbtyivEePoA xsciiecntiosftsPFOA in animal studies. 4. DuPont emphasizes that the liver is the most important 000355 Environmental Working Group || PFCs and PFOA: A troubled classof chemicals used in ScotchGard, St... Page 2 of 14 RSHS E E e E E E EE s E E E E E EEoErEE Sm m --R E o E e r mR Ta O e E --h e mm aE R E Eam --E e a n:e E S DuPontSpin vs. EWG Analysis ESe E E Ee rIEm r R--Ep m R Rrm eSe vo erT Es [recommen|i | Win3on BrOA pe E Er E S S EEEE S m e [ [e=:E=REmm=RErEEm a E E TE m oE eE E R y e E e s |eT = eeE R]], Assessment - POFpages60, 77, 78-79). 000356 `Environmental Working Group || PFCs and s Ce B S GE BEmEmnER o E i E ns e T SRa t I n PFOA:A troubled classofchemicals used in ScotchGard, St... Page 3 of 14 s S StyE onphE ERE [ E |s a= e me| s m ||E S EE E Es Ep e E aEE E p=i sBe E e pmmmSN nozeE|E EmEEeR EaE e = 5 EEt |E Ee EE Ea EsH5e EeTEm roSme Esg m msrseEEE [rome | veers | 000357 Environmental Working Group || PFCs and PFOA: A troubled classof chemicals used in ScotchGard, St... Page 4of 14 [FT iorweniomwee re ]| -- rommm r]-- a erens] rr-- TR SITs Sesie I -- types caused by PFOA or PFOS in animals (liver, testicular, breast, and thyroid) [Extract]. PFOA causes three of these tumortypes - liver, testes and breast - in 000358 Environmental Working Group || PFCs and PFOA: A troubled classofchemicals used in ScotchGard, St... Page of 14 PgrFoOwAthlihnkoerdmtoonecshainngweosriknerchsotluedsiteesr,ola,nriemparlodstuucdtiievse, hoorrbmootnhe.sI,ncarnedased ScheorluesmtePrFolOAlelveevleslsanadredseicgrneiafsiceadnthyigahs-sdoecnisaitteydlwiiptohproItnecirnea(sHeDdtLr)igolryc"egroiodde"and cthyopleesotfertohly.roPiFdOhAorwmaosnea:lso positively associated with triiodothyronine (T3), one `1A9n9al3ysainsdof1h99o5rmfoonuendletvhealts wionrbkleorosd icnoltlheectheidghfersotme3xMp'ossuCroettPaFgOeAGrcaotveegowroyrk(e>rs30in `PgProMupsI.n bTlhoiosd)efhfeacdt w10aspenroctensttathiisgthiecarlleystsriagdniioflicalnetv,elwshtihcahncootuhledrbPeFdOuAeetmoptlhoeyee A`snmaelalrsiiaemrpslteudsiyzealIsnotfhoeunhdigah reexlpaotsiounrsehigprboueptw(eoennlyP4FOInA 1a9n9d3easntdrogeinn 11:99915()E.x26t:r.act I1 nEculrledaosecdumleenvtel]s. ofPFesOtArahdiaoslbceaeunseshsiogwnnifitcoanitncrreeparsoeduecsttriavdeiodlaimnaagneimianlmsatludeiess;: 7). `stWiomrukleartsining thhoermhiagnhe,exapossigunrael ctahtaetgwoorrykaelrsso mhaady ibnecraetarsiesdk fleovrehlysopfotthhyyrrooiiddism Us, mo[sEtxltryacwto].meHny,poatnhdyrIsoildiinksemdatfofefcettsalanbreasintidmaamtaegde4..6 peBercaocufsepeenospotlfeeiwn 3tMh.e. achnedmirceaplropdluacnttivweorfkunecrtsioanreinwwoommeenn,. they have limited ability to study deseases PFOA and cancer s`tDaufPfomnitslsepaidni.ngOlny sstlaidtee t1h1aotfPtFhOeAMaisrncoht 128h2u0m0a3nmecadricainporgeesnent1a:tion, DuPont Analysis of PFOA Health Effects. [tmotcoromoge|n x|__| Reproduction of DuPont graphic PEFWOGA RIsensoptonasheu:maDunPcoanrtciunnoegqeuni,voyceatllDyuPtoolndtthhaesmneedviearornepMoarrtcehd c1a8,nc2e0r0i3nctihdaetnce sintutdhyeiirngwotrhkeehresaletxhpoofsewdortkoePrFsOAw.ithInhifgahct,PFthOeAleaxstpopsuublriecsrweacsordino1f9D8u1P,oanntd In this osuttudcyomDeusP.ont looked only at Iver enzyme levels, not cancer or any other health w3oMr,ktehres oerxipgionsaeldprtoodtuhceerchoefmiPcFaOlA,,bhuatstahlesyodniedvsetrusdtyudciaendcecranmocretraliintcy.ideTnhceeyifnound ltehsast ecxhpemoisceadlwdoirvkiseirosn wo[rEkxterrasctwe| rFeullmoDroceulmieknetly].to Wdoierkferrosm aprreosatlastoemcaonrceelriktehlyanto die of cerebrovascular disease [Extract] f3oMunadlstohactonPdFuOcAt-eedxwphoastediswroerfkeerrresdwteoreasm"oarneelpiikseloydetoofseceakretrsetuadtym,e"ntInfowrhiccahnctehresy o3fMthbeelmleavlees raerperoedxupcotsievde ttorlacotwe(IrncalmuodiunngtpsroofstPatFeOAca+nce[r)EWcGomWpoarrkeedr Stotuwdoyr.kers Document], APcFcOoArdwionugltdoptrhoebalbalteystbeEPcAlaspsriofipeodseads caalnickeelry ghuuidmealinnecsa,rcrienloegaesnedebaerclaiuesrethIitsmeyeeatrs, several proposed EPA criteria for this category * + "An agent strain, site, otrhaetxphaossutreestreodutpeo,siwtiitvhe oirn wmiatrheouttheavniodneencsepeocfies, sex, carcinogenicity in humans; PtuFmOoArsc)auasneds fteummaolresrIantsbo(tmhammamlaerryattsum(toersst)i,cultahru,slimveeer,tianngd tphaisncreatic cornietesriitoen. by testing positive in more than one sex and in more than 000359 Environmental Working Group || PFCs and PFOA: A troubled classofchemicals used in ScotchGard, St... Page 6 of 14 `eAxamppoles,tisvoe msetuedvyidtehantceisofstarnenagstshoecinaetdiobny boetthwereelninhesuomfaenviedxepnocseu,rfeor atkhnnadotwctnahnetcoaegrbee(nbatustosroncoaitnateIenmdopuowrigtthhanttotufmmeoetrrabfaoolrcimatauetsiacolonuass(essosucciehavteainsotnDs)N,gAeonrreeeraavclitldiyevnitcye oirscecllasger;ow*th control) Iikely to be relatedto the tumor response In cTohneclcuasnicoenrsoffincdaiunsgsalfolry PIFn OhAumtaondsa,tebuatrethneortesIusffaicsiternitkitnog dcroanwcordance obregtawnesenineavniidmeanlcse (ofEWcaGncWeorrkinerPFSOtAudwyarDkoecrusmeanntd].knPoFwOnAPmFeOeAtstatrhgiset CWriitthereiaocnhbeotchaeurs,ectallIeNd DgaEp tJhuenacbtilonyInotferIcvelelrulcaarlcsotmomucnoimcmautniiocnate (@16) SNeocrrmeatlelyc,hecmelilcsadlosingontamlu,ltbiyplpyroucnecshseecskiekdebGeIcIaCu,setonperiegvhebnotrienxgceceslslisve cienlcllumduiltnigpcliacnacteironc. eThsercefaonrge,rowwheunncGhIecIkCesd.deDcerceraesaesde,dcGelIlIsC=Is a sign itfhatthePyFCdso cnooutlddirbeectalcytidnagmaa5getuDmIoVr,ptrhoemyotmerask,ewIhtiecahsimereafonrsathcaatnceevren c2etlumtoorm.ultiply and produce more cancer cel, eventually resulting in Feisntarlolgy,enP,FbOyAIInnccrreeaassiensg pfrivoedrucacttiiovnitoyfoefsttrhaedieonl,iyampeottehnatt fcoonrvmerotfs t3e0s'tsosptlearntosnemtaoyesatlrsaodihoalv(earionmcarteaasse)e.blaod leMvoelles woofreksetrrsogaetno1ne:o1f Aelstthrooguegnh iesostrriosgkenfaicstroerqufoirrecderftoarinnotrypmeas obfocdanycfeurn.ctiFoonr,etxoaommpluec,hthe tclyapsesioffieeds2t5ro3geknnouswendhIun mhaonrmcoanrceinroegpelna,ceimneknetd tthoeurtaepryin(eHRaTn)d Ibsreast tCeastniccuelrar.caInnccerreasedanedstarobgneonrmlaelveplsrohsatvateebgereonwtihmplicated In bFroeuarsto,f fainvde tthuymrooridt)yhpeosvecabueseendsbigyniPfFicOaAntolyr PinFcOrSeasininagniImnaAlmser(iivcearn,stedsutriicnuglatr,he 1t9e5s1te1s0atn0d2b5ryeeaasrt-s In rat[sExtract]. PFO"AOtchaeurssehsortth-rteeermofstthuedsieestsuhmoowr ttyhaptes - iver, cCohnesmiisctaelnsttwhiatthbare"amkoddeowonf aicnttoioPn"FOkAnocwaunsteocleelaldulatro cthhyarnogiedstiunmtohrestIhnyrroolddents PFOA anddevelopmental/reproductive toxicity D16u,Po20n0t3,spDiunp.oAnltsos,taIfnfSsitdatee #th1at fPrFomODIusPonnott'ss rpeupbrloicdupcrteisveenotratdieovneolnopHmaerncthal rtoexsiunl,tsefvreonmaaft2er00E2PAreipnirtoidautcetdiaonprsitourdityy: review because of their concerns over Analysis of PFOA Health Effects [=] [] Reproductionof DuPont graphic EEPWAGhorsesspoofnosrec:onFcolrufdredomJucsotnstihdeeroipnpgosPiFe,OAE"PnAatdedveevleolpopemdenatiaslklysstosxeiscs"methnet UaS5. apcatritoon faoga"ipnrsiotritthyerceovimepwo"uonfdPiFsOwAartroadnetteedrumnidneerwSheectthieorn e4x(1p)edoifttehderTeogxuilcatory tSoubtshteaangceenscCyo)nt"rcoolncAecrtns(TfSoCrAd)e.vEelPoApImsecnotnaslidteorxiincgtythwiesraectroainsebdecfaruosmet(haecrceosrudlitnsg of a at two-generation reproductive toxcy study of APFO PFOA" + 1. 000360 Environmental Working Group | PFCs and PFOA: Atroubled classof chemicals used in ScotchGard, St... Page 7 of 14 bBlaosoeddloenvelpsowIenrtfhuel arfeseuclttesdfarnoimmraaltsrweiptrhodbulcotoidonlevsetlusdines,peaonpdlea,cEoPmApasrciiesnotnistosf hPaFvOeAshoovfaerlceosnsctlhuadnedontehattecnhtihldtrheenpwriotthectthieonh,ioghelsetsmetahasnuroendebtleonotdh ltehveelmsaorfgin "omfasragfeitny,oftheaxnpotshuerele"vfelortthheeamgoesntcyexcpoonsseiddcehtrisoldrbeen siasfJeu.stIn7,EPwAhepnarIltasncheo,ultdhe normaly be atleast 100. AreclcaotreddindgeattohEsP"A scientists,(PFuFlOlAdoccauumseenst"]siginnioffifcsapnrtinigncarteadsoessens tthraetadtimdenntot oafrfgeacntst,heIncmloutdhienrgst,haenbdraainra(ndegceroefassee)r,iopursoscthaatneg(edsecInretahsee)w,eiIgvehrt(Ionfcvraeraisoeu)s, 2gtrnhodyumpfuses,ma(dldeeeccrorefefaassspeer)ii,nngphhtiuaglhdtaddroeyslea(ydgeerdcorusepea)xsuea)l and kidneys maturation ((Fiunlclrdeoasceumnenlto)w.erBodtohsemale += <a 120) Full aGfotcerumweeann,inTghiendeexaptehrsimoefnatsSiignniwfhiicacnhttnhuemmboetrheofrawtaspuepxspoWsietdhitno2PtFoO4A dIasyhsighly Unusual, and raises Grave concerns about the toxicity of PFOA to people. SIntuadddsi.tiLono,wPbFiOrtAh cwaeulsgehst a1srigenciofginciaznetdin3c6reaarsieskInfalcotworbifrotrhIwnesuilgihntrpeusipsstainncaenoirmal Type IT`dSituadbieetsesh,avheigahisbolosohdopwrnestshuarte,heaanldthcrairsdkisorvaesmcauilnarevdeinseafosretlhaotesreIlnowf-ebirth wHiegihghbtlocohidlpdrreensswurheo, ascthrioekev,e innosrumlianlrweesiigshtatncaetearndingclhuiclodsneooid,ntIonclleudriangncies.k for Ofetmhaelrestruedpireosduhcatvievesohrogwannst,hastucPhFOasAtceasutsiceuslanrutmuemrorosu.s effectsdoencrmeaalseedansdperm pSirsooduacftfiecotns t+h, emaprmomsatartye ggllaonndd, tsuemmoirnsa.l veasnidcec,elelplidridefyfmeicstsanindttheestoisva+r,ya.ndPFOA Increases estrogen levels PFOA and liver toxicity D`DuuPpoonnttsstpaifns.taFtreotmhtaheraMtasracrhe 1t8h,e 2m0o0s3t mseenlsiatipvreeasnenitmaatlisonmoodnelsiadned#t1h3a,t ver toxicity s the most sensitive effect: Is the effect relevant? Host sensitive animal model = rat Most sensitive effect - liver enlargement + 0en0lawregeumnednetrsitnarnadtsw?hy PFOA causes liver Ves - induces peroxisome proliferation Reproduction of DuPont graphic EbeWtGheRmeossptonssenes:itTivhee.raOnliys ttwheo mstousdtiesstuhdaiveed loonoikmeodl amtodtheeleffofrecPtFOofA,PFbOutA mInay not imfoinckuetysto.say,wthheethlearbotrhaetoarty sopremcioersktehyatIsismcolroesesstentsoithiuvemabencsaubisoelogIincdaulslyt.ryIt Is tSocibeontthisstpehcaivees.nOotnebeoefnfoaubrlemtoonkdeenytsldyieaddIonsteheoflPowFeOsAt tdhoastedgoreosunpoItncaau6s-emohnatrhm PcoFnOdAucetxepdosaurcehrsotnuicdyexpos(uErxetroarctr)epIrnodaudcdtitiioonn,StnuediythIenrm3oMnkneoyrsD;utPhoentlohnogse.st qSetxuupadolysutcor.oendmuloicnttkeeedoyvteosrtdutadtwyeofeyoqeruaPartsFeOesAxtpdoodsaunmraeetrIienncp3el.oup3dle%e.foefm-aalmeMsoo;nrkeoeonvyle'yrs,mlatilfheeesmplaoonnngakenesdytsis MWeorree tseesntseidtive t"hIannthmeailelsattesottahseseefsfsecmtesntooffPFiOsAk., EPA concludes that females are pcTiahtueusiletiasvreytr,oxiasidctrihteeynatmloogsvlitratnsudta,ulldtyiheeydrvoeoirrdy,gaoonrvgafraoryn,PoFmrOasAly,estbreetpmriotsdensuotcettdit,vheientcmrlasuctdt,inIsgemntmshiuetnibverea.sinyP,sFtOeAm 000361 Environmental Working Group || PFCs and PFOA: A troubled classofchemicals used in ScotchGard, St... Page 8 of 14 and kidney. PFOA also causes mammary, testicular, pancreatic and Iver tumors oBnoetohfthseevreartaclasnecnesriainved erfefpercotsd.ucEtfifoenctsstoundythseugogveasrty,thpaittuilvaerry,enkliadnregye,mesnplteienJuasntd SSbesmeirnvaeldv.esIinclfeesmawleereraatf,feacdtevderbsye PeFffOeActastaonr tbheeloovwadroys:esowchcuerreatlvedoesfefe1c0tstwiemrese lino'wtehretrhaatnretphreodduocsteitohnatsctuaduys,esdignvifricatnotxiIcintcyre[aEsxtersacInt t|hFeulndoucummeobnftde)e.ardLikpeuwpisse, dainddndoetccreaausseedIvpeirtueinalrayrsgiezmeeonctc.urTrheedmIonlfeemoafflsepsrienxgpionstehdetroePpFroOdAucattiodnossetsudtyhat SSphloeween,d vceharngaensd sInemfionuraidivfesfiecrleen organ welghts t the lowest dose - the Kidney, dIneamtohnfkoeryosn,ePoFfOfAoucraumsoendkeliyvserteenslteadrgem(eEnxttraactt)t.heDsuaPmonetdhoasse ntohaItdreeasuwlhtaetd ikniled tmhoenkmoeryikdeeya,thso they canna: ru aut that non-iver toxic resulted In the iInndmuosntkryeyrse,sewahricchhdaorees mnoorteesctlaobsleilsyhrwelhaattedistcoahuusimnagnst.heIlnidvuesrternylsacrigenetmiesntst ofouunndd tahnadt cPeFlOlAarInsctruedaiseesdptohientsitzoemoifttohcehofinvderalin dmaomnakgeey,snoott epveerroyxidsoosmeetphreoylisfteurdaiteido,n exposed toSi"PamsFptOlhyRepomuftet,ecnhtahhenaivwseomraoklfetrerafceitdnidoInilv.negrMsoearnnezdoyvmmeroe,nlke3evMeylassnttduhdaDiteusspiosgnnhatolwwiovtrehkraetrdPsaFmOaAge Iver toxicty 15 relevantto humans. Relevance of laboratory animals findings to humans iDnuaPboonrtatsopriyn.anAilmsaolosnarseidneot#1r3e,levDaunptotnothsutamfafnIsm:ply that the effects observed Is the effect relevant? 1s th~isUmnleickhealynism relevant to humans? Reproduction of DuPantgraphic EacWtiGon,Refosupronofsewh:icPhFOaAreccaluesaerslyardevleervsaenteftfoechtusmbaynsa, lTehaestfifvievemmeecchhaanniissmmssofof macetmiobnrathnaet dhiasvreupbteioenntihdeantrifeisedusforinPdFeCcsresaosfead acreel:cmoimtmoucnhiacnadtriiaoln;topxiecriotyx;iscoelmle plervoellfseroartihoynp;otIhnycrroeiadsiesdm.production of estrogen; and decreased thyroid hormone. T"epnaeerrloryexlilesivonamkneecdeptrooofllioifvneelrryaotoxinioenc,tayfstichuerrsraetesnm,telbcyuhtuantndieisrsmudsnebkoafntoea.wcntPowenhrteootxhipeseoromppleeerp,roocxlaiilsfleeordmaetion is PGprbeosrleofrxeviresadotimIoenn pmorroolanfnekorteahtyoeiorsrnmhceiacgnhhnaofntivieasrcmceoonufznyatcmtfeioorlnaelvieolrsfetoshbpesanetsroivxbeildce eIffnofrweoctrthskeeovrfse.PrFOtAo.xicPiFtyOA cpaiantudustKetiasdrnyt,eoyxa.idcrPteynFatOlo gvalilrastnouda,claltyuhsyeervoseirdmy,aomorvmagararyn,yo,rmatseyesstitrceeupmlrarto,edsuptcaetndic,vreienatctrlaicuctd,iannigdmtmlhiuevnebrertausimny,osrtse.m bfyecPtFsOAonattohe bovealroyw,dpoitsueistawryh,erKeidinveye,r sefpfleecetns ownedreseombisnearlvevde.sides were affected "dTehbeatree.leAvadnecceiosfonpeirno1xi9s9o5mbeyprtohleifIenrtaetmiaontitoonahlumAagnesncIys oforsuRbejseecatrocfhcounrrCeantncer a(cItAiRoCn)fhorelcdautshaitngpecranocxeirsobmuet ptrhoilsicfeornactliuosniofnnhoatsrceloemveanutntdoerpesocprluetiansy a+m1o.deInof mreecdeinctatciroitnisquaese, p3eeraodxiinsgomgeopvreorlniemreanttorssc,e<n0ticslteanrolytehutmhaatnssevreersaplonhdumtoanthese cfehoxeupmnoidscuailrnsec.rteoIanasenadodtpinteeirrooncx,hietsmhoiemceTaAleRnpCzeyrpomaxneielsacotimineveixptpyrloiilcnfaehbrluyamtioagrnnolrievderacRecerlcisetinfctaolllyl,poawTpiAnegRrCthat Panels have come under heavy crRICom irom RuMerous scientists a5 being too 000362 Environmental Working Group [| PFCs and PFOA: A troubled classof chemicals used in ScotchGard, St... Page 9 of 14 heavily weighted with industry scientists AmrogoutmfeonrtPsFoOvAerbetchaeurseeleavsainscteerofchpeemriocaxli,soCm1e0proorliPfFeDrAat,iohnastobheuemnasnhsowmnaytobceause. p(Eexrtorxaicts)ome proliferation In human brain ceils (liver cells were not studied)(s3; Iprnodluisfterrayt-isopnoonvseorreedffsetcutdsidersidviesnprboypoortthieornamteeclhyatnesitsmefsfeocftsacotfinp.erFooxrisPoFmOeA, other mthaejoirmtmouxniceesffyescttesm,artehyariotiedr,edanlidpirdempertoadbuocltiivsem,trpaacntc(rienactliucditnugmotersstiacnuldardaanmdage to mammary gland turnors) "cThheismi"cdailsptroopPoFrOtiAontahtaet dtiefsfteirnsg oonfltyobxiycthefefeacdtdsi"tiisonexotf2remcealrybcolneaarndfo4r Cf1l0uo,rianesister aeftfoemcst.s oBfetCw1e0en(,PF1D9A8)5oannpdi1d99m2e,tanbionleisstmudaineds wtheerethpyurboildisghleadndd,esIcrmimbuinngetshyestem athneddrreapmraotdiuccteifvfeecttrsacitn the th+. yNrooids,tuIdimemsupnueblsiysshetdemsianncde 1re9p8r2odhuacstifvoelltorwaecdt up one dFuelslcdroicbeudmebnett)w,eebnut1h9a8s5naontdye1t99c2.omCe1u0nisdaelrsroegfuoluantdorIynshcurumtainny bflrooomd E[EPxAtract | although is toxicity profili virtually identical to PFOA, differing only In potency. References BosDseurPto,nptla(n2t00m3)a.naMgaerrchof1D8u,P2o0n0t3WDausPhoinntgtmoendWioarbkrsi.efing presentation by Paul RelWeeasset;VHiergailntiha LDeevpealrftomreCn8t aonfnEonuvnicreodnmbeynteaxlpePrrtotteecatmi.on (WVDEP) (2002). Press modHeilldteorlreerl,atePMamamnodnJiepusmonp,erGfWl.uor20o0o1c.tanAoastiemp(lAeF,FcOo)nseexrpvoastuirvee ecsotmipmaarttemsenoftal HpeeraflltuhoarnoodctEannvoiaotrenm(ePnFtOa)lbSlcoioedncleesv.els in humans. DuPont Haskell Laboratory for repYroordku,ctRiGon(S20t0u2d)y. ofOraamlm(ognaviaugme)petrwfol-ugoernoeorcattainocnat(ean(eAPlFiOte)r Ipnerratgse.neRreaptoirotn) pNor.epTa-r6e8d89f.o6r.3,M,UsStE.PPAauAld,miMnNstbryatAirvgeuRseRceosredaArRch22(6H-o1r0s9h2a,m,RePvAi).ewSepdonIsnoUr'SsESPtAudy `Adminstrative Record AR226-1137 (pages 262-295; PDF pages 179-191). to CF-a8y:errweesaultthsero,f bWlEo.od1c9h8e1m.iLsitvreyr tsetsutdiyngof(nWoatsphuibnlgitshoend)W.orks employees exposed (epiDduePomnito.log1i8s7)9.toPDerr.soPnoawlearn(dmecdonifciadlenstuipaelrimnetemnodefnrt)o:m SDrt.atFuasyreerpwoerattohner Wstausdhyin-gAtuognusWtor2k6,s l1i9v7er9.function survey and coronaryheart disease mortality Gro`vAelefxaacnidteyr., BFin(a2l00R1e)p.orMto.rtDailviitsyiosntuodfyEonfviwroornkmeernstaelmpalnodyOecdcuaptatthieon3aMl CHoeatlttahg,e EScPhAooAldmoifniPsutbrlaitciHveealRtehc,orUdriAveRrZs2i6ty-1o1f3M7in(npeasgoetsa,1A4p3r-i1l4266;, P2O0F01p,agReesvi4e0w-e4d3)i.n U.S. perGfllluolraonodc,taFnDoiacnadciMdanpdreold,ucJtS.ion19p9la3n.t.MoJrOtcalctuypaMmeodng35(e9m)p:lo9y5e0e-s4.oAflaso reviewed I3n7-E3P9)A,Administrative Record document AR226-1137 (pages 140-42; POF pages fuoSriobcinhsekmii,ca.l F1C98-71.43Tw(poe-rYfelaurorooroaclta(ndieeta)mtmooxinciituym/ccaracribnooxgyelnaitcei)tyInstruadtsy.oRfeport p0r2e8p1aCrReOd0f1o2r;3MB,ENSQt.: P1a0u8l7,-M0394i, OnctbonbyeRriek1e6,rsL1a9bo8o7raRttoerviiaeesweIdnc.in SUtSudEyPANo".Revised DPrOaFftppPF1O5A7-H1a6z4a)r.d Assessment-Robust Study Annex" AR226-1137, (pp. 260-267; MechBaiengiesl,msLBof, eHxutrrtath,eMpaEt,i,cFtruammeo,r SinRd.i,icOt'ioCnonbnyorp,erCoxaisnodmCeooprko,liJfCe.ra2t0o0r1s,in male CD rats. Toxicol Si 60(1): 44-55. 000363 Environmental Working Group [| PFCs and PFOA: A troubled class of chemicals used in ScotchGard, .. Page 10 of 14 ofafc1, iPluAtblyl.eixcaFiHnnedaaellrt,ehp,8orU(tn2i.0v0eD1ribsv)ii.tsyoMoonfrotMafilnEintnyevsisorttouand,myeAnopftriawllo2ra6kn,edr2sO0c0ec1mu,pplaRtoeiyvoeindeawlaetHdetaIhnlet"h3L,eMtStDceehrcofaotrluorm WMiar,sCchoarrrleecsteAdueorn a4n/d15r/0a2f" UH.aSz.arEdPAAsAsdemsisnmietnrattoifvePFROecAoarnddARit2s2S6-a1s09w3i.th Page & `3Hn.d 2Ofl0is0me1n.p,lAaGnnWte,epimBdpuelrmoliyeoewle,osg,MiMc.1,a99n3aH-lo1yc9sk9is6n.ogf, ReBpeB.iv,siSoekdwreeasdtotIf,n cUXa.Sr,eEBounfrvri3irMso,nDmeJecMnattaaunlrdPcrMhoaetnmedicectlai,oln Agency Administrative Record AR226-1137 (pages 156-159; POF pages 53-56). Edwafridess,, LEAK.G,20E0i2s.nerS,EEMPR.,CaKnocsearryS,taCtLis,tiHcsanRkeevyi,ewBF1.97M3il-l1e9r,99B:A,GCvleergvgie,wL inanad SHitno:le/sPeOeFr.cNaantcieonraglovC/acncre/r1In9sti7tut3e.1Bse9etcht9eiso)dnas.,i10.. Avalable online at Edw|Raerdss,, LOAKG., 20E0i2s.nerS,EEMPR.,CaKnocsearryS,taCtLi.s,tiHcsanRkeevyi,ewBF1.9,7M3i-l1le9r9,9;BA.,CChlieldghgo,oLd Caanndcer IbnysttihteueI.ntBeremtahteisodnaa,i HClOa.ssAifviacialtiaobneofoniCihnieldahtood Cancer (ICCC). National Cancer Hetp/seercancer.Gov/csr/1973. 1899/sections ht. CEdSwRa,Rride1ss5,,73LB-AK1.G5,9290E,0i2sT.neesrtSi,Es.EMRPN,aCtaKinoocnseaalrrySC,taanCtciLse,triHcIsannsRtkeietvyui,teew.BFB1.e,9t7Mh3ie-ls1edr9a,6,9B:HAD,.S,eCcAltveiagoignl,saLbolfteahnodneline at itp: seer cancer.govicsr/197s3ec_ti1on9sh9t9ml/. ocnalricnEiennvotigrehonnefmespnk:taa/sl/sPecrsosltmepectnuitobn(.eAxegteeprnancayc.lfg(rEmeoPvArvi)e.ec/wonr2dd0rcia0sfe3pt.l,aaDyFlr.eablfrtmuafdirneyall2d0g=0u3i5)d5.e4l4iAn5vea.silfaobrle (reBphroDosudpuphcaotnnitoonoHxasystk)uedleylt:hLyMalib]xo,rtaumtrooernyoo.fap2mo0lm0yo2(.ndiiDiueumvoersola-olmptem(tehCnyAtlSael#nea6)n5,d5a3ol0np-eh7-a1g--ef4nl)eu;roarptoai-yoo(nmdeigfalu(r2o-(meCtAhySlen5e3)3,0a-l7p2-h5a)-;fupoorloy-(odmiefiguaolr2o-m(epthhyoisepnheo)n,ooaxoyh)a,etahiyplhla-',-d(ophmomspohniniicuobsiasl(toxyI2s,o1p-reotphylanaeldcioyhoblis(C(AomSe#ga6-7f-l6u3o-r0o)-;],anadmmwoatneiru(mCsAaSt#(7C7A3S2-?166-555)3.0-U7S0-3); (DE&ne)vciSerumobbnmemiresns2ti0ao,ln2PR0re0oc2tee.citAviveoadnllfAargboelmenc0oy1n:l/i0Tn2oe/xo0itc3 Stoub1s/t1a5n/c0e3;CoSnEtrHoQl1A2c0t2-(T1S5C2A4)7SAe.ction 8 Hip: ar. 293.6ov/ oppUcanedoTc/ne/wse. im. m(dofnuDoouarpomo-mnmotentHhiaysulkmeelnSlea)Ll,ab(aoCprAhataSo-#rfyl6.3u5o23r00o0.-27o.1m-Se4ug)ba;c(hp2ro-ol(nypi(chdotfsoupxohircoiont-cymoesxttyuh)dyyle:etnhMeyi)xl,t,uarpehoaf-poly ploolryo(-aaifmieugoarlo2me-t(hpyhloensep)h,oniooahox,y)aaltphhyai'-,(pdhlosapmhmionincloubmis(soaxly-(2C,1A-Geth6a5n5e3d0i-y72b:i5s); 6f7a-m6e3g-a0-)f;uoarnod-1w,ataemrm(oCrAiSu#m7s7a3lt2-(1C8A5#S) (T5e5l3o0m-e7r0-83)P;hoIsshoaptreo)p.ylUaSlcEonhvoilr(oCnmAeSn?tal RPreocteeicvteidonfArgoemn0c3y/:27To/x0i2c tShurbust0a3/n1c3e/C0o2n:trSoElHAQc-t02(0T2S-C1A5)07Se2cAt,ionFe8b(reu)arSyub6m,is20s0i2o.n Avaliable online at htp:// www. pa.Gov/oppYtscate/doc/Besub3/0826h0i3m1. DeceDumPboenrt.172,002020.1.ThUe.Su.pdEaPtAedAdcmoipnyisotfraDtuiPvoenRtecPorordduActR2S2t6e-w1a0r6d9sh.ip on repeuaPteodndtosHeasakenldloLnaeb-ogreanteorray.ti2o0n02r.eprRoedsucttsivoeftaonxiortayl sgtauvdaygeIncootmsbifnoredpo9l0y-day (o(aCmxAe-Sg1a,N(2u-2mebhtyheadrnreo6dx5ly3ye4lt5)h-y8ll0p)-h4ap;-lnynyo(dndr-lHoPu-Voo)rm.oemgUeaSt-hhEaynnvceir)roox(ny1m:ee1nt)thae(lrt,sPwrlioottmhecaetl8ripohmnaoA.rgfoleeuntochryeo:-r)Toxic tShurbuat1a2n/c0e7/C0o1n:trBoElHAQc-t1(0T0S1C-A1)49S1e5ct.ioNnov8(eem)beSrub5m,i2s0i0o1n. RAevcaieliavbeldefornoimne10a/t15/01 itp: jw.03. Gou opptini caeldoc/Sesub/Se1015hi0m1. Nov`eDmubPeonrt.252,00220.02D.uPU.o5n.tElPrAotAdemlionmiesrtrpartoivdeucRtecstoerwdaArdRs2h2i6p-1u1pd4a7t.e, presented asseHsils,meRnNt.,ofCrtihsypr,oTiHd.o,liHucrulleay,cePllM,tumRoorsse.nthEanlv,irSoLn aHnedaltShinPghe,rsDpVe.ct1180968(.8):Ris4k47- 000364 Environmental Working Group || PFCs and PFOA:A troubled classofchemicals used in ScotchGard, ... Page 11 of 14 57. 1 Hurley, PM. 1998. Modeofcarcinogenic action of pesticides inducing thyroid follicular cell tumors in rodents. Environ Health Perspect 106(8): 437-45. lon1gOitlusdeinn,alGWa.na,lyBsuirsleowf,SMeMr.u,m Bpuerrrfilsu,oJrMoocatnadneMsaunldfeoln,atJeH((P2F0O0S1)). anFidnal report: A tpeesrtflrueosurlotosctfarnoomatmea(lPeFeOmAp)lloeyveeles pianrtrieclaitpiaonntstooflitihde a1n9d94h/e9p5a,ti1c99cl7i,niacanldch2e0m0i0stry fElpuiodriomcihoelmoigcya2l2m0e-d3iWc-a0l5s.urvellance program, 3M Medical Department, crosOs-lsseecnt,ioGnWa.l,anBaulrylseiws, oMfMs.,rBuumrrpies,rfJlMuoaronodctMaannedseull,foJnHat(e20(0P1F).OS)Finaanldreport: A hpeemrfaltuoolrootayctaanndoautrein(aPlFysOiAs)riensurletlsatfiroonmtomacllieniacanldcfheemmiaslterye,mptlhyoryoeied phaorrtmicoinpea,nts of tMheedi2c0al00DeApnatrwtemrepnta,ndEpDiedciamtiuorlofglyuo2r2o0c-he3m-i0c5a,l medical surveillance program, 3M IH. O1l99s8e.n,AGnW.e,piGdielmliloalnodg,icFDi.,nvBesutrilgeawt,ioMnM.of, rBeuprrriosd,ucJtMi.v,eMhaonrdmelo,neJsS ianndmeMnanwdietlh, 2`o2c.cuAplastoiorneavlieexwpeodsIunrUe.tSo. pEePrAflAudomrianoicsttarnaotiicvaeciRd.ecJorOdccAuRp22E6n-v1i1ro3n7 M(epdag4e0s(71)4:7614149; PDF pages 44-46). perfBliueogreola,cLt8a.n,oaLtieu,oRnC.L,eyHduirgtt,celMlEfuancntdioCno:oki,n vJCi.tro1,9i9n5.vivEof,feactnsdoefxavmimvoonstiuudimes. Toxicol Appl Pharmacol 134(1): 18-25. C.,vDohmarS,aaMlD,.,FS.,GanTjiammm,s,VKB.G,.,PaMromingtiaannoi,, MSMa.n,dPaWlealnszhaa,nsP,., WThVa.ye1r9,97.KA.P,roNsatgaetel', d`ieentlhayrlgsteimlebnetstirno'lmaicned doupepotsoitfeetealffeecxtpsoasturheigtho dlooswesd.osPersocofNaetsltrAadciaodl Socri US A 94 (5): 2056-61. regisDturPyonno.t (31892957-)2.6-H1a.zaPrrdepcahrareadctbeyriLzBa.tioBnlefgoerl,hSuemnainorhReeaslteharCc8h eTxoxpiocsoulrogeisCtA.S Hollowell, G., Staehiing, `Spencer, CA and Braverman, NLEW..,30F0l2a.ndSeresr,uWmDT.S,H,HaTn(n4o)n,,aWnHd.t,hyGruonitdearn,tiEbWo.d,ies. IEnxatmhienUantiitoend SSutravteeys p(oNpHuAlaNtEiSonTi()1.98J8Cltion 1E9n9d4o)c:riNnaotlioMneatlabHe8a7l(t2h):an4d89N-ut9r5i.tion 3., O'HHaedidr,owCE,.,JE.M,itPcahlelolm,aMkL,,GHEe,rAolsla,n,R0W.,C.W,alWsiblrlieanm,s,SJER..,, FKaniixg,hJtO, GaJ.n,d GKlaeginn,onR,Z. n1e89u9r.opsMyacthearlnoaglicthaylrdoiedvedlefoipcmieenntcyodfutrhiengchiplrd.egnNaEnncgylaJndMeSdub3s4e1(q8u)e:nt549-55. junctUipohnaalm,IntBLe.r,cDelelaulcaramcpomom,unNDi.c, aWtuiroln,byB paenrdfiTuroorsiknoa,teJdE.fat1t9y98a.ciIdnshiibsidteiopneonfdegnatp `on the chain length of the fluorinated tail. Int Cancer 78(4): 491-5. Liu, RC., proliferator, Hurtt, ME., ammanium pCeorofki,uoJrCooacntdanBoiaetgeel(,C8LB)., o1n996h.epaEtfifeccatroofmtahteaspeeraocxtiivsiotymeIn adult male Crl:CO BR (CD) rats. Fundam Appl Toxicol 30(2): 220-8. AvaiNlaabtlieonoanllTinoexiactohltotgpy:/P/reohgpr.animeh(sN.TnPi)h..g2o0v0/2r.oc/1t0otch10R.ephotrmtl.on Carcinogens. asseEsnsvmiernotnmoefntpaelrflPurootreocotcitoannoAigceancciyd a(EnPdA)i.ts 2s0al0t2s., RNeovviesmebdderraf4,t 2h0a0z2a.rdU.S. EPA Administrative Record AR226-1136. prezi"oTshia,yeDr.,, KWAe.i,shRuohnlse,n,WVR.L,.,HHaoswedmeasnhe,llJ,anKLd.,voBmuchSaaanla,n,FS.OL2,001C.ookAlet,erPeSd., psurbocsltiantiecaglrdoowstehsaonfd1d7aaillpyhas-peetrhminpylroodeuscttriaodniolin. mHaulme mRiecperoedxp1o6s(5e)d:p9r8e8n-a9t6a.lly to the Ednevvierloonpmmeennttaall PtrooxtieccttyioanssAogceinatceyd(wEiPtAh).ex2p0o03s.urePrteolipmeirnfalruyerroioskctaasnsoeicssamceidntanodf its salts. March 17, 2003. Godfrey, KM and Barker, DJ. 2001. Fetal programming and adult health. 000365 Environmental Working Group || PFCs and PFOA: A troubled classofchemicals used in ScotchGard, ... Page 12of14 Public Health Nutr 4(26): 611-24. Bu1l;l H6a0l:es5,-2C0N. and Barker, DJ. 2001. The thrifty phenotype hypothesis. Br Med and Ecrhiiklsdshoono,dJ,groFowrtshena,ndT.,hyTpueormtielneshitoon, iJn.,adOuslmtolnifde,. HCypaenrdteBnasrikoenr,36D.(5)2:00709.0-Fe4t.al 0). 2E0r0i2k.ssoEnf,feJcGt.s, oFfosriszeen,atT.B,irTtuhomainldehchtiol,d)h.o,oJdadgdrooew,thVWo.n,tOhesmionsnudl,in CreasnidstaBnacreker, syndrome in elderly Individuals. Diabetologia 45(3): 342-8. EarlyErgirkosswotnh,, JaGd.u,ltFoIrnsceonm,eT,.,anTduormiislkeohftos,trJo.k,e.OsSmtornodke, 3C1(a4n)d: B8a6r9k-e7r4,.DJ. 2000. 0). 1Er9i9k9s.soCna,tcJGh.-,upFogrrsoenw,thT.i,n Tcuhoimlidlheohotdo,anJd., dWeianttherf,roPDm.,coOrsomnoarnyd,heCaratnddisBeaarskee:r, longitudinal study. Bmj 318(7181): 427-31. diseEarsieksisnolna,teJrGfae.ndAFnonrsMeend, T3J4.(32)0:021.57C-h6i1l.dhood growth and coronary heart insulOinngr,esKiKstaanncdeDaunndgecra,rdDiBo.va2s0c0u2l.arPdeirsienaastaelingraodwutlths.faiBleusrte:PrtahcetrRoeasd Ctloinobesity, Endocrinol Metab 16(2): 191-207. F. 20S0te2t.tlPerr,evNa.l,enBcoveeat,ndP.r,isSkhafamcitaoyrse,foHr.,ovZeermweeli,ghBtS.a,ndStaolbleisnigtsy, VinAcahinlddrPeanccfaruodm, OSebyecsheRleileast, MaectoaubntDriysoirndr2a6p(i2d)t:ra2n1s4i-t9i.on: the Importance of early growth. IntJ Palazz0lo, M (1993). perfluorooctanoate (CAS 13-week dietary toxicity N. 3626-1) in male rats. sRteupdoyrtwiptrhepTa-r5e1d8f0o,ra3mMm,oSnt.ium Paul, MN, Reviewed in US EPA "Draft PFOA Hazard Assessment" AR226-1079. cell Caodoekn,oJmCa.,s Mbuyrraamym,oSnMi.u,mFrpaemref,luSorRooacntdanHouarttet:, aME.pos1s9i9b2le. eInnddouccrtiinoen-rofelLaetyeddig mechanism. Toxicol Appl Pharmacol 113(2): 209-17. R., KBeuntneendhyo,f,G,3, JCr.ostLai,edeGr.,, PE.l,cOolmsbeen,, CG.,aFnadrrTarh,omD.o,rdHa,nsP.en2,00K2.., TIwoaxii,ciHt.,yJoufng, 6AmMmonotnhsi.umToPxeircfolluSocrioo6c9t(a1n)c:at2e44i-n2M5a7l.eAClysnoormeovligeuwsedMionnUkSeyEsPaAftReervOireawleDdoIsninUgSfor EPA "Revised Draft PFOA Hazard Assessment-Robust Study Annex" AR226-1137, p. 244-253. subaGcoultdeenrthheasl,usE1m.o,nJkeessyupt,oxiOCc.i,tyGesituld,y:RGFlaunodraMde*hrFilnugo,rJoSc.he1m9i7c8a.l FNCi-n1e4t3y.-daRyeport Cporreppoarraetdiofnor(3MMa,ttSat.waPna,ulM,N)M.N SbtyudIynstNio.tut1i3on7a-l05R0e.seRaervciheawnedd DinevUiSopEmPeAn"tDraft PFOA Hazard Assessment" AR226-1079. Derelanko, M. 2000, Toxicologist Pocket HandbaokWashington DC, CRC press. `enzGyimlelsl,anldi,poFpDroatenidnsM,aandnedl,choJSl.est1e9r9ol6:. Saesrtuumdypeofrfolcucourpoaotcitoannaolilcyaecxidpoasnedd hmeepna.tic `AAmdmi3niIsntdraMteidve2R9(e5c)o:rd5A60R-282.6-R1ev1i3e7w(epdaginesUS15E3n-v1i5r5o;nmPeOnFtaplaPgreot5e0c-t5i2o)n. Agency publiTcohmeaalst,h.L.fn20tJ02O.ccTuhpe EInAvRiCromnoHneoaglrtahp8h(s2)p:r1o4g4r-a5m2:.changing attitudes towards 2 flaMwelendicdke,ciRsLi.on2b00a2s.edThoen aInARuCnteevsatleuadthiyopnotohfedsiis(.2-eItnhty)lnOecxcylu)pphEtnhvailraotne H(eDaElHtPh): (3): 284-6. albinMoetrraitcsk., FMinaalndrepMoarrti.asR,epAo)rt(1p97r7e)p.ar2e8d-fdoary3oMr,alStt.oxiPcaiutly, sMtNudbyywiItndhusFtCr-i1al43BiionT2e6s9t.,LaRbeovriaetworeidesi.n UStSudEyPANoa.dm8i5n3is2t-r1a0t6i5ve4,re3cMorRdenfeurmebnecre ANRo.22T6--11704792.CoC, Lot hepaPteorcraorncei,noCEg.,enSihcapoe,roLxiasnodmeWiplrloalimfse,raGtMo.rs o19n98f.attEyffaeccytol-fCrooAdoexnitdase, DNA 000366 Environmental Working Group || PFCs and PFOA: Atroubled class of chemicals used in ScotchGard, ... Page 13of14 sPyhnatrhmeasicsa,l a1n5d0(a2p)o:pt2o7s7i-s86i.n cultured human and rat hepatocytes. Toxicol App! d<2)ownHgurffa,dJi.ng2,00a2n.d IuAnRdCerm-gornaodgirnagphcshe,miicnadulsst:ry3 Ipnefrlsuoennacel,paoinndt uopfgvriaedwi.ng, 2I4n9t-e7m0a.tional Agency for Research on Cancer. Int ) Occup Environ Health 8(3): Int|eSreasstss, ().DO2I0)02p.oliLcey.adIInAt)RCOctcouwparEdnsvcioromnplHieaanlcteh w8i(t3h):W2H7O7/-I8.ARC Declaration of `Ca: ncBearin(eIsA,RCCJ).. 2L0a0n3c.etTr3a6n1s(p9a35r9e)n:cy7a8t1-t2h.e International Agency for Research on CancKeirei(hIuAeRsC,)P.. L2a0n0c3e.t T3r6a1n(s9p3a5r9e)n:cy78a1t.the International Agency for Research on La+ncBeutrtOonnc,olA.42(010)34:.. Is industry Influencing IARC to downgradecarcinogens? No authors listed. 2003. Transparency at IARC. Lancet 361(9353): 189. Cerui,miMPn.i,20A0,0.CrPisrteisaenno,ceL.a,nBderinndaurcdiob,iliAt.y, oFfarpieorlio-xViescochmieosl,inS.a, hSutemfaannini, S and glioblastoma cell line. Biochim Biophys Acta 1474(3): 397-409. `DepiYearnrge,, JQW.., A2b0e0d2i.-VPaoltuegnetrdsiu,ppMr.,esXsiieo,nY.o,f tZhheaoa,daXpYt.,ivMeolilmerm,uGn.e, rNeelsspoonn,seBDIn amnidce aucpido.n IdnitetIamrmyuenxoppohsuarremtaoctohle2(p2o-t3)e:nt 3p8e9r-o9x7i.some proliferator, perfluorooctanoic. InvoYlavnegm,enQ.t,oXfiet,heY.p,eArloexxissoonm,eSEp.r,olNieflersaotno,r-BaDctiavnadteDdePrieecrerpet,orJaWl.ph2a00i2n.the Pihmamrumnaocmoaldu6l3(a1t0i)o:n 1c8a9u3s-e9d00b.y peroxisome proliferators in mice. Biochem onthYeantgh,ymQu.,s Xiaen,dYsapnldeenDeopfiemrircee,.JCWl.in20E0x0p. IEmfmfuecntoslof1p2e2r(2o)x:is2o1m9-e2p6r.oliferators `evidYeanncge,fQo.r,thXiee,inYv.,olEvreimkessnotn,ofAiMn.h,ibNietilosnono,f cBeDll apnrodliDfeePriaetrirone,aJnWd.de20v0e1l.opFmuernthteirn ptehryfmliucoraoncdtasnpollecniacciadtrInopmhiyce.indBulcoecdhbeymtPhhearpmearcooxlis6o2(m8e):pro1l1i3f3e-ra4t0o.r `perLoixui,sRomCe.pHroalhinf,eraCtoarnsdonHurratt,LMeyEd.ig19c9e6l.l fTuhnectidiornecint veiftfreoc.t FofunhdepaamtiAcppl Toxicol 30(1): 102-8. perfBloeurrtohoictaaunmeesu,)lfaonndatWea,llaancde,N-KeB.thy2l00p2e.rfPleurofrlouoocrtoaoncetsaunloaftoen,amido ethanol; p3eroxisome proliferation and mitochondrial biogenesis. Toxicol Lett 129(1-2): 23hypoHlaipuegmhiocme,ffBecatnodf Sppeyrfdleuvoorlodo,ctOa.no1l9c9a2c.idTh(ePFmOeAc),hapneirsflmuournodoecrtlayniengsutlhpehonic. acid (PFOSA) and clofibric acid. BiochimBiophysActa 1128(1); 65-72. `ComVpaarnatRiavfeeltgohxiecmi,tyMo.f, pAenrdfeirusoerno,-nM-Ed.e,caBnrouincera,cidR iannrdatMsatatnied,hDa.ms1t9e8r2s.. Toxicologis2t: 148. deca`nGoeiocrgaec,idMEin arnatds.AnTdoxeircsoeln,ApMpEl. Ph1a98r6m.acToolxi8c5(e2f)f:ect1s69o-f80n.onadecafiuoro-nEffecKteslloinfgp,eCrKf.,luVoarondecRaanfoellcghaecimd, oM)n., heMpaetniachaInnd,icLeAs oafndthPyertoeirdssotna,tuRsE.In1t9h6e7.rat. Biochem Pharmacol 36(8): 1337-44. 1988V.anPeRrfalfueoirgohdeemc,anMo)i.c, aVcainddaennd Hleiupivdelm,etJaP.b,olMiesnmzhiannt,heLrAata.nLdipPiedtser2s3o(n7,):RE6.71-5. suppGluetmsheanltla,tiDoMn.,onPitlhcheerr,esGpOonasnedtLoapnegrlfeiyu,orAoE-.n-1d9e88c.anEofifcecatciodf t(hPyFrDoAx)inien rats. ) Toxicol Environ Health 24(4): 491-8. 000367 Environmental Working Group [| PFCs and PFOA: A troubled classofchemicals used in ScotchGard, ... Page 14 of 14 GpieorxfiHina.vrorrFiosud,neMdcaWan.mc,iAcUprpaaiclihTd,oxILnicCCo5al7n18d31(B4/)i6:rmb7ia2cue3m-,d3i.fLfSe.rs1f9r8o9m. 2A,c3u,t7e,8t-otxeitcrtaycholforodibenzo-pdef|icBioeonkcsytaifnf,maRlC.e,raMtosorter,eaRteWd.wiItnhgaplle,rfGiBoraonddecPaentoeircsoanc,d.RE.Tox1i9c9o0l.AApnpdlrogenic Pharmacol 104(2): 322-33. perfDiavvoirso,deWca,nc2incd.a,cdVaonndedne Hneouvvoelf,atJtPy aacnidd Paentdercshoonl,esRtEe.ro1l9s91y.nthEefsfeicstsInotfhe rat Cpids 2610): 857-5. effeNcetslsoofnp,erDfL.i,joFrroadzeicera,noOiEc,aJcr.d.,(EPrFiOcAso)n,onJEh.,umToarrra,l,Mc)elalnuldarM,atahneds,InnLEa.te1992. The immunity fn Fischer 344 rats. Immunopharmacol Immunotoxicol 14(4): 925-38. `S+u1 mEmnavriireosnmfernotmalthPerorteevcitsieodndArgafetnchyaz(aErPdA)a.ss2e0s0s2m.eAnntnoefxpeorffrlouboursotocsttaundoyic acd and ts sais, November 4, 2002. U.S. EPA Administrative Record AR226-1137. Next Page: Nonstick ansKiBirds infogens.org 000368 Environmental Working Group [| PECs and PFOA: A troubled classof chemicals used in ScotchGard, St... Page 10f7 IL SOL GEIS Ee PFCs GLOBAL CONTAMINANTS. wes Si, Co-- mme EA PEG SE Rr econ _-- Ar awTm T; RA _ Tr ee rE M' RSfetaS " ar Toe - ShopperssGGuuiiddeeftooPPFECCss SoCtIETdT e ra, CL rants: Teflon and other non-stick pans kill birds aid emtusots and veterans have kr ne own o fuoe rnedehcadeaeeastteaherateT,ocefouplnoteno-aacrorasmtseead.saoTneodnur - eTrssof weedeGerpnosomnneinasgtarndSsoeutof30 Tr en rei paresetyed for the first time. ats hae The ubiquity of the deaths - soleast 100 websites devoted to the care of pet nien 1es975r,oninbnaesiSonfgetheaoeaonrlynSpeaeBr-TrsEeCvfiSeemseeidyb hpeordeaths of fv pet birds allowing ivecosas (tympcus haani)e en awiorthn3n0hmitees non ApA ATa aR "pvoleymeseer rfouamtedefsevaeorf"nrbuE etnorepscoavoefrcedmidncthwoeinhtexFtFr2E4e haoursn. cCliAnriacnald tgp (Sg . nonstick cootings are not | Lo ras 8) nrrSetisethcreereicmhtryeoedomceotn.ouinetSAcxseoraotaneiancctosmpheacuiress [|l[| KoUgTeef folon apace ory of | roma .7 |1 efia ar | E I E in i Eesenmtanmumbierssof |i i T imme e. e | pB iercei nt ofte ihoeucnht ooiacurkssca doineds |||| IvRy N C n EEr E E @= hdta paehlaefdo,pofoosAsteihoberilcrtIhrynivcoekfsstom,iwvageanrtyeing ||| |empmmpeeamss a SBenT ar tA or |4|] EtTvooebhoetSceovaetreoedyAwCahhaenngTreifonloa onmc:heomiv scatlePeTa p.sc"Faurrp tahneroIfnr 4vestWigEao tioonm lthse 000369 Environmental Working Group || PECs and PFOA:A troubled classofchemicals used in ScotchGard, St... Page 2 of7 `(coonaetefdo.rPeTaFcEhgpaesn)I.ntTohxiecnateiwonhheaast bleaemnp rbeuplobrstwederIen speovleyrtaeltreaxfoituiocroaevtihaynlesnpeec(iPeTsF,E) but this Intoxication has not been previously reported in a poultry flock." 21. oSctiheenrtinsotnssthiacvkepnaontsiadenndtioftihederthKeitpcahretniceuqluaripomfefgnatstchoatmpisourensdpofnrsoimblTeeffloornthaendbird ndoenastthisc,bkuptanasmaorneghetahteemdaanrye PchFeOmAicaanlds otthhaterhagavseebsetehnatmsecaisenutriestds Icnotnhseidaeirr hwihgehlny toxic 51. Next Page:Regulatory gapsleadto global PEC pollution References: 1. B1l97a5n.dfoArdcaTs8e, oSfepaomlyotnetPr2a,fiHuuogrhoeetshyRl,enPeatptoiissoonnMi,ngWiInldceorcskpaitnieMlPs. Faecbco2m2p;a9n6i(e8d):b1y75p-o6l.ymer fume fever in the owner. Vet Rec 1975 2. PBooluyctheetrraMf,idEornomeltehrylTe3n,eBgearsmiundteozxicAaJt.io2n00i0n. broller chickens. Avian Dis 2000 Apr-Jun;44(2):443-53 3. fEluliosrDoAp,olMyamberusryasSAa,pMoaternttiinalJWs,ouMrucier oDfC.ha2l0o0g1e.naTtheedrmoorlgyansiics of acids in the environment. Nature 2001 Jul 19;412(6844):321-4. Related websites: Huapzaatrsdisx.acnodm DSeesacrrcihpttihoeni:r UdaptAaLbaSsiex is a very comprehensive pet bird care website. Lists k`ecyowmomrodns.hoAulsseohloilndkshtaozaarvdisanaansdsopcrioavtiidoenss,aasvieaarricehs,esnagnicnteuafroirers,essehaorpcphinbgy,toonpliicneo.r chat groups, and many other bird-related Issues. iAtsps:o/c/iwawt.iaoanvo.forAgv/ibaansiVce_tcearrien.ahrtimanAs:voBiadsic Bird Care Description: stewardship. ABsesoccoimateioanmoefmAbveira,n fVientderainnaarviiaanns vperto,mloetaers aavbioauntmAeAdiVcpirnoegraanmds. and policy statements. PetPlace.com article: Dangers in the Kitchen Dtetspc:r/i/pvteivown.pPeettppllaaccee..ccoomm/aorftfeircsleasc/caerststSohowa.awsepa?ltahrtoifD=m3e5d3i4cal and wellness pet sinefaorrcmhaatbiolne.thFreoautguhreas uasnera-rfcrhiievnedloyfdmaotarbeasteh.an 1350 pet-related articles `DTihtep:N//avtoiwownma.clocCkoactkiaetlsi.eolraS/oacritiectlye:s/Gcearnee/rgaenlcaBrier.dtCmalre qDueescsrtiipotnioann:dTahneswofefricibaulllweetbisnibtoeaorfdtwhiethNastcihoenadlulCeodckcahtaitesl aSnocdie"trye.adFiengartouormeass"of cockatiel-related articles. hPttlp:a//wneptl-apneetst.:cpoemt:sH.ocuosmifnge/eFdeberddi.nhgtBmirds Description: Planet pets organizing, and offering qsuearlvietsy tpheet-pruebllaitcedbyinffionrdminagt,ioenvaalnudatriensgd,ursceelse.ctiFnega,tures a free online newsletter, kids korner, ask an expert, links to services. HBeiarldtshainsdsueMsoarned 000370 Environmental Working Group || PFCs and PFOA: A troubled classof chemicals used in ScotchGard, St... Page 3 of7 PDescrripotiontb:ieOdersiircnoemstttooxrieicffonrumrgecss and their owners. Includes health ts and general care for your bid TheaStlakTloiThGeoVetth-eCvagee,d cBiormd/AHRoTuIsCiLnEgS/CBonIsRiDdSe/rPabtiirocnshousiHnTg.M tDoevsectrisp,tiforne:e TnaelwkslTetotTerh,epVeett-spIsecainfiocnlairtnieclveest,ereitcn.arian consultation service. Links hBDtei:src/dr/iCpirtvaiooznbyw:i-dBSicrardfaeCztryay.zGycuo1im5dioennefOownrsliiPnelea/naatvrsitaacrynesdb/aPpsoelidasniontnsmSs.an Diego, CA. `saCfoempprleahne.nsive lst of poisonous plants and household poisans and well as list of Bhitred:s N' WaDyisdeszmianyesComiwisdom/siiem. sDheoscprpiipntgi,onc:haGtutiidnge,tionpfaorrrmoattsioanndanadthmeirsceexaltaincepaeutsbbiirrdsd.-rOefafteerds sdiotzee.nsOfoffelrisnksto access t thousands of articles searchable by keyword, topic, author and website. AiStPoC:-A//Mwavnaogwi,ngasPeptcBair.doTroxai/qcuosestreyes=/PTSFeEairncc=h170 DIpnersoacnmrioimptateliso.hnu:UmAsameneetrhipecraisnnecaiSrpocichsi,eetnpygrifenvoeent(thseecarprurceehlvte"ynPtaTinodFnEaolflteoCvrifuaietnledt8fyeadtroo,wAnpniaioimnsadlaasnbdlexesiusrftefspeortriontg "Managing Pet Bird Toxicoses'. `Additional Links: iStarltingvTalkstarlingtalkcom warning.htm pHeatrrot parrotpartotparrot com/birdheakth/kola. hm iExtapt:iec xpeottviectpetvet.net/aboumt.l KHapy:teeww Kaytee.com companion_animas/birdsihealth/ U Peta RSaL uk,OTs Mact, s 16.Mand PPiepti8r[dwRtepaprettbirdrepor com/antices/dangers, tml Tih:e//PwavrrnogtaCrhrrootncichlreosnicis, com/departments/hazards htm hFiea:t/h/ehroCmaer.ecAovgieacroy,cal-ackson283/index htm Thhie:/p/awrrwootwSopcairertoytsoofcAiuestt.roarlai.aaul Settasnley's Quaqkuearkvelrlveile com/features/tfe. asp HLaitte:bewrwCowmpaalenbyer.com/doss_book/13/thirty_three_dangers.ttm THhetepA/vtihaerayviary.comisefion shim Aivtit:ecwEwxawticavBiitredcs.com/Sirdcare. html stuad:giZe.oorng budgie,rs/infoltefon.iol Those Majestic Macaws! . 000371 Environmental Working Group | PFCs and PFOA: A troubled classof chemicals used in ScotchGard, SL. Page 4 o7f hte: exoticbizdcomteiHoimn! iTtaoki:nwg CwaredOef.Ycoourm=NKeiwonBinrsdon/safethtym. Lhotv:ebairdwCenltoevrebirdcenter comhazardstm. iCtocek:atiwelwCwotCtoacgkeatielcattagenet/hazarmdls iNtepw:LnE/nwgelansd Ex,oticorBiar/dpSoalncstouinasrm.y Stoputih/BwaaymsBoirbdaySbociidestoys. com/hozards im Aoust/in Bsird CaUustinbirdeub, com/dangerous. im 0t1dpWorlwdiA.vciaoriresidaviaries.com/textt/efslotny,es/ http://www.oldworldaviaries.com/text/miscellaneous/buying_a_bird.htm D i signest Aviarbbt iiieggsnneew ssttccoommf/omv oida.reiym.him Wpewe w8eTboyiseds.com/frstid. im PReitpsBiIrdmeamrmbeerSsaftertiypoTdipcsoma~nDdAIdnfaomrmSat/iaonkbrdiunlt pFairtrso/tLOnnwlwi.npeartatineorgiteton hemi sielpls ohneilnaeoniinecom/ortices/art3973.a5p Siepn:egfalw mokasnestcomy/snegal/Teflon/toins htm Fteaptihferos a.ndfeTaatlhl:ersandtatsor/haliday. he Biipd:sI8ywD.oninradsbydonna.com/BIRDS_BY_DONNA/Basic_Sird_Cax.html Kiipndnefsis .cluKbindinessclu nbcapetsBirgSafety. Rpock/porwt Roorsotckportrst com/Birdsafetyips im Apni/malwLo.verasnpeitmSaholpoverscpoemtwshahtosnpe.vs tm Tihtep RjewswMvaecceaiwmacaw.com/pagesLielcorehemi Wh olN-vinw gpsarrotsco. m/fac: tm Apfri/canwLo.vebaifrtidcSaoncoiveetbyiedsociety comlovebidcare! oprith Aime.riccaoncCokck.atoireallaSroicciieet/yhazords. be AHnUg:el wwiingspaArvrioartybreeder.comparrothazarhdism ApiBliMn pAveitarbiiesrbreader.com/hazardism, 000372 Environmental Working Group || PFCs and PFOA: Atroubled classof chemicals used in ScotchGard, St.. Page 5 of7 `hTthpe:A/n/ismwawl.CpleitnihceaofltChlcifatroen.net/htmi/body_household_dangers.htmi Bhitrtdspa:fe/./cwombirdsafe.com/story_bird33.htm Ntettpp:e/t/ssuww.netpets.org/birds/healthspa/poisohnst2m.l tArtipzio/n/aaAzvaivainaBnrbereedeedresrAss.soocriaa/tBiionrdCsahrtem.l Ahviitapn:/A/vzeancuheary.avianavenue,com/BirdSafhettym.l Aistkp:o/r/.duwrpwepteratra.com/Birds/Househald%20Dangerbtsm. htLtopn:g/I/swlandlPiaprarrortotSsoocciieettyy.oofrNg/enwarYmofrulkhtm itp: /www.iparrotsociety.org/teflon!. htm "hTthtep:G/r/ewywwP.laacfeticangreys.com/hints/emergency. htm hBtitrpd:s/BpiarrdrsotBfiredast!hers.tripod.com/care itm h"tTthep:F/a/mwiwlwy.PfeatmiSlhyopwetshow.com/toxocosis. html Diotcpt:owrswF.ostderrsafnosdtSemrsimtihth.com/Asticles/bird_commoninjuries.cfm Piatrpr:otws wCwan.apdaarrotscanada.com/birdowner/forthenewbirdownhetrm.l Biitrpd:s[Jwusht beWiarndnsjausHtawvaennFauhnavefun.com/durabilty._info.htm Ahtmtepr:i/c/awnwwA.nhiemaailtHhoysppietta.lcAosms/oLciiabtriaorny/preventh-1t8m.l Shotltdapn:'/s/FweesdoladnadnsPpeett.Scuopmp/lpieetsperspectives/bird_basics. htm Bhriitt:is/h/Cvoevlnu.msbpieaaS.PbeC.AcalFactsheets/birdcahrtem. "iTthpe: A/fvviwavnenMpeedtimceidniecCihneeschtest,com/avian/discussions/chemicalpoisoningtext.asp. PiettpiPa/r/rwotwwClpuetbpUarKrotclubuk.co.uk/help/hazards. htm "iTthpe:p/eftwvBeirnd.pWeebtsbiitred.co.uk/housedangehrtsm. hQitu/afkuewrwPeawra.kqeueatkerparakeet.com/baubhuayn.! Hhttop:/u/wwsw thoonuPsettoTnalpkettalk.com/Column_Bird_Buddiehst.m htHtepx:ALviyarny hexaviary.com/hexlocal.hte Bhitrtdps:o/f/awwFwebaotahte.rcom/article_L1.htm AhliltpC:rfeawtu.resalAln-cirmeaaltuHreoss.pictoalm/care/bhitrmd Feathered Friends Forever 000373 Environmental Working Group | PFCs and PFOA: A troubled class of chemicals used in SeotchGard, SL. Page 6 of7 tof fetheredltendsforeveroralhomesafety. hal poid/Cwrazy Birdetazycom/Soxinsim Tthpe:P/awrwotoi.ttPhareipouarrtoietoarlou.com/HFazaarrrdso.tsehitm_ iTheesWiLanedonnowvienrdVheotevreirnvaery,cCoemn/tbeirrdcare nm Aprizwonna i,rdaS2ubppsluypply.com/birdSs20care_basiicms Tthe PpetCAiRE I/unfmonr.mpeadtui/oenOPCeetncsteArrtaiclesrBirdeTox.tem TthpeiHoflwst.c BlisrdcbNeiwdssi,eCteorm/HBNOoctnov/pages/chronihciLm WCinpRfowse AniinmtaosHeovspeiltaclom/BIrd. im H5ormownyt's,Worvledtsocfopme/tpsetcarelbiedscaluumnm.l JaDniicwev'tBvi=rzdoHmaev.ecnomi3aniceMar/feathered/Care. Tphe/eiwd Hatiindeling com/vet him Tihpei/TAreutecpuaerproatrrot homestead. comEnvironmentalsheedsl Tphe/Grewy-c,hIe.emkoendtPoanroa,keeedto ~bmarsh/cheeky/dosdonhttsm.l PDaRn:dy tnhae AvfdicnaenntGcreoymp/ahrrtotmiartices/parbte_-ab-ebhirad htm QnRiutaptkp;e/re/wPvwaerwroQqtuusaakkeerrpparrEraosts.,ccoomm/aqEtpipSs/dmaonraee_rtsh.ooufgthetiso_non_Htemfion.htm/ AGniwmaleRe,scauer-LoenadgoueroofPIeotwcaare Bids asp WNiaps:atwchtAviawn aEduscataiontcSooccmiehtfyoastevrguiidea.unnl DRanetCo.untyamHaunmeasnoeciSeoyci.ectyane tuscare/bied_roauma.l MHopn:treawlsBirbdiaannddeExxoottiiccAvneitmcaolmHoasvpiitaanl Hemi P[ arrot passions UK i ---- spa/tew. birdife.comicare/dangers.hem! ppret/ty Bwidspretybirds.ney arotsafenome.ntm TStheped:lAJonnwi=mwaailRaeNnceiotrmwooanrioknne2t7v21rk.com/birdsbrar/artcevaisepw? Petotpt:hFi=nw/dpweurbip/eantiemra.icrag/rfeo/ubrgn/ali13n.d4e0x4.5ca8r? 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Page 1 of2 SRE SSIS Ls WARIS Rr PFCs Gapet GLOBAL CONTAMINANTS Part: T_T Regulatory gaps lead to global PFC pollution "nasA serlthougthoh roughlymatsetstpeedobpelfeoraesstuhemyeatrheatsoclhd,emtihcearel IIsn ncoonlesguamlerrepqruoidurcetmseatnrote test most + Consumer Posts PECs BChaecmaiucsaelsoffohrsh,eablatshiceftfoexcitcsoaltogaynSytusdtiaegseoonf Tperfoldounc,tiSocno,tmcahrgkaertdiangn,darnedlatuesde. ee Poel Esarynare ocnitihmeiamlasrakreetbeing conducted only now, ity years after these chemicals went sons soremm cUhnedmeircatlhse aTonxdicpuStutbinsgtannecwescCoomnptoroulndAcst,onchtehmeicmaalrkceotmpwaintihoeustccaonndcuocnttiinngueanmyaking Heath Carcar SFutdiumednotfiatrheyelssrcerfefeencitnsg osntupdeieosplperioorr tthopereodnuvcitrioonnm,ebnu.tSfoemweerctohmapnhanaifesofcoanlduct pr - y aalp.plTihceatigoonvsetronmtheentEaPpAprfoorvnesew80cpheemricceanltporfodtuhcetsieoanpipnclluidce aantwyiittoohxnicosity data at EAA rteysptirciacltliyocnsu,rsuosruyalIlnynIantuerces, tbheacnautshreetehewegeosv,erWnhmeenntdlaatcaksaaruetphroorviitdyetdo, rtehqeuyesatre ET athnryetehiwnegekmse,reattahannatvhear,agEelgrhatteofof1s0enveenw chdeamyi.caIflsthweirne aaprpernoovadlatIta,[tehsethan eae GmoivceranlmewnitlJhusatrimiehsuampaprnovhaelalwtihthorrtehseulesnvofircoonmmpeuntter(EmPoAde1l9s97t3h,atGsAsOtm1a99t4e).Ifa Fthoer cmhaermkiec,altshtehaEtPAarceoanlrreeaqduyesotn ---- Spoeverran ooer_A--en on PEGs dWtahhtiaachtohnIetlygcehwnehemerianclalilyt iccsaancnansuoustbisndtgoawnhitaitrahmto,eut m---- Wmirimhe duma= gelsse ohe trehqeuteosxti.ctIny pdroatcatitce5, tsheieskminegntso f-- o tIhnadtepsetunddieenstasrceiernetqiustisrehdavoeny after Ra e mSoamanme,e acI tion tpof ePrEC eBolt adecmocnustmrautlinaagbtpooedtedynotifalevairdemnc,e3 i1%. r Ssm t Shopperos Gouide to PFCs rGeoccaedsess.that typicalv takes =BE = TTT cnheemnicaal)hosthbeemeonrientrreodcuecendatInto ewe ron aera- mer ti CCSchoiememmnitecirasctlses,woictlhhekenmloeiswcsahslcoiwfeotntroimstteessstutnfhdoaertrihstaiavnnepdeboietpeslntewoexailnclid-tsytt,hueadnieedndvtaihrreoenlmeteshsnotsl.iekfeTolhyretwfhIesiwcthhat BorkS HG Lm ae Sicnicelnutdiestwsiduencsopvrearsedd,poolfstienonaoccfidtehnetaelnlyv,ireonnvmiernotnmoerntRaolmacantapsotpruolapthieosnt,h3atc5anthe Case now for FRCS. art 9: Sidebars, Sidebar 1: Reform of Federal Law Sidebar 2: The regulatory precedent of pesticides. Next Page: Recommendations 000376 Environmental Working Group || PFCs and PFOA: A troubled classofchemicals used in ScotchGard, St... Page2 of2 Backtotop 203, Tavironmantat vi o chon 000377 Environmental Working Group || PFCs and PFOA: A troubled class of chemicals used in ScotchGard, St... Page 1 of3 GPLOBFALCCONsTAMINANTS at mam TT ietucton meine TL Consumer Products 8.PECs Faople Everyvihere Recommendations for Action on PFCs `What shouldthegovernment do? teas `What shouldthe chemical industry do? - ee - renee a - r" n _ ese oo Cn _ mesement Shoppers Guide to. PFC EE TT oT What should the government do? en LE LR SE The unique combinationof prevalence, toxicity, and persistence that characterizes S S nyRST T + ieon sA c cout th revi of remain FcnnsndlAs Ee hcA o itty y gts niSe s lreeetdy * COrmDFCaSe(nCenldsteorrs fesorraesDisseyasoenCCooenttrea ollbaeSnaodpP,nrevA eennticon))sShoueilgd naedeoepst, Sus e Rp l I rtp ase asSypysiySsnseDsti0lesmSaas hleYSAi PFCs are highly toxic, extraordinarily persistent chemicals that pervasively veL en ToknesoSSbsR oar.csenCcooinetA 20sforodamltlyebnk hth ste eIyT a T ete T SSH 000378 Environmental Working Group || PFCs and PFOA: A troubled classofchemicals used in ScotchGard, St... Pag2e of3 + nThde aElPlAnemwusdtathaavoen tahechuenmeincaclumtbhaetreIsdaalurtehadoyrtoynttoheremqaureksett.any + fTprheoeyduEscPhtAioowmnutashntadthtashavleeectIhfheetmhideceadalar,toaausrtehuoqsrueiedts,ytietsdonrstuesspanefonetdfgaeoncethrheaemteimdca,asltosr If Sensitive portion of the exposed popuiation. + tChheemfiocoadlschtahiantmpuersstisbteibnatnhneeedn.vironment or bioaccumulate in Cbheeemxipcoaslesd,foiunnddrIinnkhiunmgawnast,e,infporoodducotrsIntdoowohriacihr,cmhuiscrtebnemight toormobu,ghmullyt-egsetneerdaftoiontahllesthuedailetshffoeccustesd ionlkownodwosne,tawrogertmb-to{Cooroognawintsai,vcethhedametivicenalclolpuhmdaeernsmtes,nstSihtteuidvbieoeedsnytd)opmodiuensftitsneaIlmkseoeborecgcahonnadfuunncoctifteiadsoc.ntmiaosnnd Backto top What should the chemical industry do? `+ cThheemicchaelmsictahlatinbdruesatkrydmouwsnttpohPaFsOeAouit tthhee eunsveiorfonPmFeOnAtaonrdthoether phaupmearnprbootdeyc.tiIonnclpurdoidnugctusses in Teflon, Stainmaster, and Zonyi TmheethcohdesmitcoaldeitnedcutstarlyPmFuCsstIndetvheelhopumaandn mboadkye, paunbdliccoanndaulcyttical gbelnoemroanlioporpiunlgatsitoun.dies o find the loves of thar chemical in the TehnevicrhoenmmiecnatlalinpdeursstirsytemnucsetofdiaslclPoEsCest,hiencblruedainkgdopwenrfplroordou:ctasndand Mpoalnyuffuaocrtou-repoolfytmheorseprtohdautctasreikpeerGsiosrtee-nTtex, and discontinue the oCfhtehmeiicralprmoadnuucftascttourtehrespumbulsict.fully disclose the PFC Ingredients Back to top What can you do? fAolotdh,ouagrh, saondmerenxpiosnurweastetor -PEyCosuacraenucnhaovoasideatboleav-oitdhemyahnayvePFbCesennffouutnudrein EpBuFrCc"haesceosnoofmcyonosnuhmuemrapnrohduecatlst.h aDnodinwgisdowainlilmahlesl.pHroerdeucaerethseoimmepaUcpst:s ofthe oPthhaesreeoquutitphmeenutsethoaftTiesflhoenataendd Iontyhoerurnohno-mset.ickIfcyoooukwcaarneafafnodrd T0efrleopnlaacned prnoodwu,cdtos swoi.thWhotehnerhenoant-esdtitcokhPgEhC tceamspteirngastuermeist, fumes that can be harmful 000379 Environmental Working Group || PFCs and PFOA: A troubled class of chemicals used in ScotchGard, St... Page3 of3 + hDaovreopteutsbeirTdesf.loInn ofractn,ona-vsotiidckancyooKkiwtachreenIenqyuoiuprmhenotmethaIftyou hCiognhtatienmspTeerfaltonuroer doutrhienrgnuosne-.stFiuckmecsomfproonmetnhtessethmaattaerreiahlseactaend to quickly Kil birds. + Wtrheeantmyeonutspfuorrchstaasien faunrdnidtiurrteroersicsatrapnecte,, daencdlifniendopptrioodnualcts that rheatvalelenrost. bMeoesnt pofret-hterseeatcehdemwiictahlchtermeiactamlesntbsycqounetsatiinonPiFnCgs tthhaet. might contaminate your home and family. + IAnvdoiicdatbiuoynitnhgatcliotthhaisngbteheant cboeaatresdafTorefwlaotnerfa,bestlaionr,ootrhedrirt arletpeerlnlaetnicyv.esMyaonuyowfiltl hheelspeschoraitnikntghsearPeFCPFeCc.onBoymybuaynidngthe associated global contamination. `MTihneismeizceanpabcekhaegleddifnocoodntaanidnegrrseathsaytfaarset fcoooadtsedInwiytohurPFdiCest. to ikneaepwigdreeavsaerifertoymofsocaoknitnagintehrsr,ouignhcltuhdeinpgacfkraengcihngf.ryPbFoCxsesa,repiuzszead boxes and microwave popcorn bags. `+ tAhveoipdhrbausyein"gflcuoosrmoe"toircs"paenrfdiuootrhoe"ropnertsheoniangcraerdeiepnrtodliustc. tsAmwointgh. pnarioldpuocltissht,haatndmisghhatvicnogntcarienaPmF.Cs are lotions, pressed powders, Backtotop ifo@ewa or 000350