Document LKOVr2vp93XDj27rREd2ZOanz

UiS'cr^r^ -tf/Y HANDBOOK of INDUSTRIAL TOXICOLOGY by E. R. PLUNKETT, M.D. Industrial Health Services m Barberton, Ohio CHEMICAL PUBLISHING COMPANY, INC. New York 1966 UCC 022483 PLAINTIFF'S EXHIBIT UC-4182 UCC 022484 ppm of air 36 ! nervous system d cells by reduction in glutathione s and nephritis cidneys May be delayed up to two days) Garlic odor of breath Numb;iing of hands and feet Nausea, al cramping Abdominal tender Weakness * Bronzing of skin ing) Pulmonary edema Jaunegaly - Hematuria, hemoglobinand oliguria Anemia and leukoblood calcium Increased blood ck Delirium and coma yon of T-waves in all leads Ire with normal conduction r'e 0.2 mg/liter g body weight (but not to exceed dose) every 4 hours the first day; econd day; then 3 times daily for week emulation in patients with reduced ; blood and packed red blood cells pportive :urs is usually complete rline respirator 37 ARSINE Periodic examinations of urine should not exceed 0.5--1.0 mg arsenic/liter of urine Preclude from exposure those individuals with diseases of blood, liver, kidney, and central nervous system ASBESTOS Synonyms: Amianthus Amphibole Chrysotile Earth Flax Impure Magnesium-calcium Silicate Mountain Cork Serpen tine * Stone Flax - Many mineralogical names Description: Flax-like fibers; fireproof Occupational Exposure; Clutch facings and brake linings Roofing and insulating materials Asbestos cloth products, valve packings, gaskets, pipe cover ing Auto undercoatings Threshold Limit Value: 5 million particles/cu ft of air Toxicity: Arsorption: Inhalation Pathology: Asbestos warts, from fibers that penetrate epidermis Pulmonary interstitial fibrosis via mechanical action of long fibers (20-50 microns) in terminal bron chioles Grade I: Asbestos bodies in alveoli Grade II: Asbestos bodies * Thickening of alveolar walls Perivascular fibrosis Grade III: Coarse honey-combing of lungs Scar ring in upper portions Thickening of Pleura Adhesions Benign asbestos pleurisy may occur without other significant pulmonary disease Signs and Symptoms: Anorexia Cough Dyspnea Loss of weight Pallor Weakness Cyanosis Clubbed fingers * Decreased vital capacity UCC 022485 ASBESTOS 38 Diagnostic Tests: Asbestos bodies in sputum X-ray changes after 10 years or more of exposure: Stage I: Increased density at both bases with an occasional superimposed granular pat tern Apices clear Stage II: Decrease in clarity of cardiac silhouette Densities extend to the periphery of mid dle and lower thirds of both lung fields --"ground glass appearance" Accentuation of hilar markings Stage III: Shadowing of middle and lower thirds of both lung fields Cardiac shadow obscured--"shaggy heart" Treatment: Symptomatic and supportive Disability: Disease ceases to progress on cessation of exposure Question of cancer not yet answered Preventive Measures: Adequate ventilation Wet methods Mechanical filter respirator Physical examinations of exposed personnel annually, in cluding vital capacity measurements and chest x-rays Preclude from exposure: Persons with pulmonary disease Persons under 40 when diagnosis of asbestosis is definite Persons in whom disease is progressing, regardless of age ASPHALT Synonyms: Asphaltum Bitumen Earth Pitch Mineral Pitch Petro leum Pitch Description: Brownish-black solid Occupational Exposure: Insulating Paving - Roofing Waterproofing - Paints and varnishes Wood impregnation Threshold Limit Value: None t Toxicity: Absorption: None Pathology: Local irritant Signs and Symptoms: Acnc-like lesions and Tar melanosis: yellow skin ( Irritation of eyes and : Diagnostic Tests: None Treatment: .4 Remove by scraping, o Symptomatic and sup Disability: No permanen Preventive Measures: Loose clothing, closed at n Protective goggles Personal cleanliness Synonyms: Pyoktaninum laureum Py aminophenyl) methylene zophenonimide Description: Yellow flakes or p Occupational Exposure: ^5 Antiseptics Dyes Threshold Limit Value: None Toxicity: Absorption: Inhalation Pathology: Sensitizer Tumors it Signs and Symptoms: Dermatitis and burns * ing Yellow vision UCC 022486