Document LK65Ez9dn0ZJ0b6wjrg19ZM0Q

R&S 006057 PB80-807662 Toxicity of Vinyl Chloride Citations from the NTIS Data Base Search period covered 1969-March 1980 National Technical Information Service Springfield, VA 22161 R&S 006058 CONTENTS Bibliographic information...................................... ii Ordering reports.......................................................... iii Prices of reports................................ 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Published Searches are bibliographies with abstracts that provide a quick, inexpensive way to determine which reports in the NTIS data base are of special interest to a user. The Searches are prepared by NTIS information specialists and are available in many topic areas; they are updated at regular intervals and cost S30 each. The cost of a Published Search will be credited toward the cost of a customized Online Search in the event the Published Search does not meet ones needs. A complete list of current Published Searches is available free by requesting brochure number NTIS-PR-186. If your needs are more specialized and you want a custom Online Search, please write to NTIS or call the Online Search telephone number, (703) 557-4640, to discuss specific areas of in terest with an information specialist. V *r tom position Stability and Degradation Products o t selected Materials For Solar Heating and Cooling nandia Labs., Albuquerque, NM. ^Department .of Energy. ATTHDP: Arnold, C. Jr; Trujillo, R. E. *200511 Fid; 111, 13A, 710, 97J, 97N G3AI/922 Mar 79 36p Contract; EY-76-C-04-0789 Monitor: 18 (bboyoou) Abstract: The composition, stability and thermal degradation products of a variety of structural plastics, heat transfer fluids, tnermal storage media and sealants, which have been proposed tor use in solar heating and cooling applications, were either defined generically by analysis or obtained by surveying the literature. This information will be used to aid in the assessment of the environmental impact ot these materials. By gas chromatography-mass spectrometry (GC-HS), beta -phenylnaphthylamine, a suspected carcinogen, was tentatively identified as a component in the heat transfer fluid, UCCK1. In addition, aromatic components which might be toxic were detected in all of the heat transfer fluids that were derived from petroleum sources. By TGA (thermogravimetric analysis) , it was found mat nolvsti Ifide, Neoprene, poly(vinyl chloride) and poly'(vinyl fluoride) were the least stable solar heating and cooling materials. In the event of a solar system failure, these materials would be expected to thermally degrade and evolve such toxic substances as H sub 2 3, HC1 knd Other solar heating and cooling materials were found to be lore thermally stable and hence should not outgas if tne solar system fails, (ERA citation 04:038480) Descriptors: *Heat storage, *Heat transfer fluids, ^Plastics, ^Sealing materials, *Solar cooling systems, *Solar heating systems, Chemical composition, Failures, Gas chromatography, Mass spectroscopy, Materials testing, Neoprene, Polyvinyls, ?vc. Stability, Sulrides, Thermal degradation. Thermal gravimetric analysis. Toxic materials Identifiers: ERDA/140901, EHDA/36060J, EHDA/360o04, NTISDS FAN 1-78-0681 'J 113 Prices: PC A03/MF A0 1 R&S 006063 Economic Impact Studies of the Effects of Proposed OSHA Standards for Vinyl Chloride Sooz-Allen and Hamilton, Inc., Florham Park, NJ. Foster D. Snell Oiv.*occupational Safety and Health Administration, Washington, JC. Final rept. 'M992C3 Fid: 61, oJ, 5?, 57 Y, 573, 68G, 68A 27 Sen 74 418p Contract: DL-7 4-167 Monitor: OSHA/TS-79/005 GHAI7922 Abstract: The Final Report presents Snell's evaluation or the technical feasibility and resulting costs of compliance with various target levels of exposure to vinyl chloride. It includes data on monitoring and personal protective equipment, and worker medical surveillance. The conclusions and recommendations cf this report: (1) Achieving no detectable levels of vinyl chloride monomer (VCM) mainly through engineering means is judged not feasible with present technology in the VCM and polyvinyl chloride (PVC) sectors. (2) Compliance costs increase rapidly with decreasing VCM target levels and represent significant engineering uncertainty or unreasmility beyond 10 ppm ceiling and 2-5 ppm time weighted average ror VCM industry and 15-25 ceiling and 10-15 TWA tor PVC industry. (3) Area monitoring, especially in PVC plants, is recommended to OSHA as a compliance requirement regardless of the target level selected oy OSHA. (4) This report recommends that OSHA establish phased requirements for reading VCM target levels to allow the collection or additional VCM monitoring data to fully assess the efficiency of corrective steps. Subject to review in light of current meaical findings, and as they become available. Descriptors: ^Economic impact, *Vinyl chloride, ^Chemical industry, ^Industrial hygiene, *Polyvinyl chloride, ^Toxicology, Feasibility, Exposure, Monitoring, Concentration (Composition) , Standards, Regulations, Cost analysis, Technology, Protective clothing, Air pollution, Surveillance Identifiers: ^Occupational safety and health, *Indoor air pollution, *Toxic substances. Monomers, Maximum permissiole exposure. Standards compliance, MTI5LAB0SH ?n-297 702/33T 'ITIS Prices: PC A18/MF A0 1 80 2 R&S 006065 proposed Regulation: Vinyl Chloride Occupational Safety and Health Administration, Washington, DC. Final environmental impact statement. F179UHU Fid: 6J, 68H, 57U GHAI7920 5 Sep 74 220p Hept* No: OSHA/IS-79/003 Monitor: 18 Abstract: OSHA proposes to regulate producers of vinyl chloride, polyvinyl chloride, and articles made from these suDstances by requiring that tneir employees not be exposed to vinyl chloride above specified levels. The major impact of the regulation is expected to be a reduction in the number of workers contracting liver angiosarcoma and other forms of cancer. A concomitant adverse impact is expected to be substantial increases in capital and operating expenditures among manufacturers, along with reduced productivity. Ihe effect of these cost increases will be increased prices for products made from vinyl chloride and polyvinyl chloride. .Major alternatives are considered along with the proposed standard. nescriptors: *Vinyl chloride, *Environmental impact stateaents-final, *Tndustrial hygiene, *?olyvinyl chloride. Regulations, Substitutes, Standards, Capitalized costs. Operating costs. Exposures, Plastics, lafety, Toxicity, Chemical industry, Liver, Malignant neoplasms, mgiosarcomas. Costs, Productivity, Carcinogens Identifiers: Occupational safety and health. Environmental chamicai substitutes, Cancer, Environmental health, JJTI5LABOSH "3-297 005/1ST MTIS Prices: PC A 10 /M F A 0 1 SO 3 Vinyl Chloride -- An Information Resource S?.I International, Menlo Park, CA.*National Cancer Inst., KD. Div. of Cancer Control and Rehabilitation. AUTHOR: Kilby, Thomas H. F1751T1 Fid: 6T, bJ , 6F, 44G, 57Y, 57 0, 58G GRAI7920 Mar 78 122 d 'ept Ho: NIH-78/1599 Monitor: DHEW/PU3/MIH-78/1599 Bethasda, Abstract: A discussion of the link between exposure to vinyl chloride and the occurrence of toxic, nonmalignant illnesses involving sxin, bones, liver, lungs, and blood is provided. The regulatory history of vinyl chloride is outlined. It is pointed out that the potential ror human contact with vinyl chloride is great. About 2.0 billion kilograms of vinyl chloride are produced each year in the Jmted States. The vinyl chloride is produced at 15 plants employing 900 workers. Vinyl chloride is also polymerized at J9 plants, employing more than 5,500 workers. The Environmental Protection Agency has estimated that approximately five million people live near enougn to vinvl chloride facilities to be within range of detectable airnorne concentrations of the gas. The production, uses, and dispersion of vinyl chloride are discussed and evidence of its toxic and 3J carcinogenic effects are summarized. Strategies tor the control of 09 vinvl chloride are suggested. The appendixes contain a list of V) vinvl-chloride-related compounds, an approach to evaluation and o control of vinyl chloride exposure, and sources for additional o CD information. o<J> 0) Communities, Demography, Environmental health. Health planning. Methodology, Public health. Strategies Identifiers: HRP/GAA, H3P/ZH, HRP/CK , HEP/AD, Vinyl chloride. Chlorine organic compounds, diseases, Toxicology, Industrial medicine, health, \T7 IS HR AM H? HHPGE0/YN0, HSPOCC/XZ, Exposure, Occupational Occupational safety and HR?-00 23012/33? MTI3 Prices: PC A06/.MF A01 80 4 in yl Chloride: A Review, 1B35--1975; an Annotated Literature Collection, 19 7 6-- 1 975 ; a Literature Compilation, iy76--iy77 "Toxicology Information Response Center, Oak Ridge, Energy. (9500221) AUTHOR: Warren, H. S.; Huff, J. E.; Gerstner, H. B. ?12 9 5E h Fid: 6T, 6F, 57Y*, 6BG*, 6B A GRAI7915 Nov 78 218p* Contract: W-7405-EHG-26 Monitor: 18 TN. * D epar tmen t of Abstract: vinyl chloride (OH sub 2 CHC1) (VC) is a colorless gas, produced and marketed in large volume primarily as the base roc its versatile and relatively inert homopolymer, polyvinyl chlorida. The toxicological problem posed by VC has broad ramifications rooted in the long interval between the industrialization of tne VC/PVC processes and the first recognition of the potential carcinogenicity of the VC monomer. This time delay represents the latent period of the carcinogen within the human organism and may mean that the vc-associated cancer cases detected to date represent only the beginning of a growing clinical statistic. This report on vinyl chloride consists of three parts: Part I provides a review of vinyl chloride and its health-related aspects as summarized from tne literature through 1975; Part II comprises an annotated, ksyworded, indexed collection of 555 references (1BJ5--iy75) which empnasizes fciological effects and includes references concerning analysis and Control in both workplace and environment; Part III is an 'updated collection of references which extends the bibliography througa September 1977. This bibliography was compiled from the major scientific abstract literature. Current journals in appropriate discinlines were also scanned. References are arranged alphabetically by first author's name. A permuted title index is appended for easy access to the bibliography. (ERA citation 04:02471 3) descriptors: * Bibliographies, flan, V Lnyi monomers, Biological etrects. Carcinogenesis, Health hazards. Organic chlorine compounds, Reviews Identifiers: 5F.DA/5S0 3 05, ERDA/570000, Abstracts, Humans, *Vinyi chloride, UTI5 DH ORVL/Tiac-78/3 MT IS Prices: PC EIJ/flF A0 1 R&S 006067 80 S JO w o o O) o o) Sum mar v Characterizations of Selected Chemicals ot Near-Term Interest 00 - r.vironmental protection Agency, Washington, DC, Office ot Toxic Substances, J ! ^inal rept. I 71 1 14 H 4 Fid: 6T, 6J, 68, 68G, 57Y, 57U, 99 GRAI/913 Sep 76 31d ?ept No: EPA/560/4-75/008 Monitor: 18 See also report dated Sep 75, PB-246 356, Abstract: This report includes summary characterizations ot 8 chemicals of near-term concern to ZPA, The report summarizes (a) health and ecological effects and environmental Dehavior, (b) sources, environmental levels and exposed populations, (c) technologic and economic aspects and (d) steps that have Deen taken and are being taken. Descriptors: *Environmental surveys, ^Chlorine organic compounds, *Dichlorodifluoromethane, *Vinyl chloride, *Phtnalic acids, *Ch lorof ora, *Lead (Metal) , Lead inorganic compounds. Lead organic compounds. Esters, Ecology, Public health, Sources, Technology, water pollution. Air pollution. Toxicology, Exposure, Industrial nygiene. Concentration (Composition) , Economics, Solid waste disposal Identifiers: *Ether/bis(chlocom ethyl) , *8utadiene/hexacnioro, ''Polychlorinated biphenyls, *8 ipheny 1/perchloro, * Me thane/tluor j-tcic- hloro. Freon 11, Freon 12, NTISEPAOTS P3-292 419/9ST NTIS Prices: PC AOJ/MF A0 1 so 6 R&S 006069 Mine Combustion Products Identification and Anaysis--3olvent3. Fire Retardants nitrasystems, Inc., Irvine, CA.*Buraau of Mines, Washington, DC. Annual rept. 30 Sep 76-19 Oct 77 AUTHOR: Paoiorefc, K. L. ; Kratzer, R. H.; Kaufman, J. ; Naltahara, J- H. R101234 Fid: 81, 13L, USA, 99A, y4H GRAI7912 net 77 118 p Rept `Jo: SN-8220/A5-F Contract: H0133Q04 Monitor: BCJMINES-OFR-1 2-79 See also report dated Sep 76, P3-267 6b8. Abstract: The objective of this program was to develop a reliable and meaningful basis for assessing certain health aspects, namely toxicity hazards created prior to' combustion by articles employed in underground coal mining operations. The present investigation was concentrated on haloganated materials, specifically solvents, degreasing agents, fire extinguishants, additives, and conveyor beltings. Descriptors: *Coal mines, ^Thermal analysis, *Fire resistant materials , *Solvents. Gas chromatography, Mass spectroscopy. Chemical analysis, Laboratory equipment. Separation, Thermal degradation. Polyvinyl ^hloride. Additives, Fire extinguishing agents, Mins safety. Halogen Organic compounds. Belt conveyors. Degreasing Identifiers: *Toxic substances. Procedures, NTI5DI3M pp-292 324/1SI `JTI5 Prices: PC A06/MF A01 ao j R&S 006070 Ambient Water Quality Criteria: Vinyl Chloride Environmental Protection Agency, Washington, Standards Div. F08Q2TT1 Fid: 6T, 6F, 8A, 57Y*, b7H, 6dG*, 68D, 1978 9 0 p* Monitor: 18 DC47D criteria GHAI7yiO and Abstract: Section 304(a) of the Clean Water Act (33 U-5-C- 1314(a)), requires EPA to publish and periodically update water quality criteria. These criteria are to reflect the latest scientitic knowledge on the identifiable effects of pollutants on public naaitn and welfare, aquatic life, and recreation. This report presents water gualitv criteria for vinyl chloride. It presents concentration criteria for the protection of fresh water and saltwater aquatic lire. It presents 'safe' concentrations for humans, and in the case of suspect or proven carcinogens, gives various levels of incremental cancer risk. A section 304(a) water quality criterion is a qualitative or quantitative estimate of the concentration of a water constituent or nollutant in ambient waters which, when not exceeded, will ensure a water quality sufficient to protect a specified water use. Under tne Act a criterion is a scientific entity, based solely on data and scientific judgment. It does not reflect considerations or economic or technological feasibility nor is it a water quality standard and in itself has no regulatory effect. Descriptors: *Water quality, ^Toxicology, *Vinyl chloride, Alkene compounds. Chlorine aliphatic compounds. Criteria, Toxicity, Water pollution. Aquatic biology, Marine biology. Fresh water biology, Conc^n tration (Co.mposit ion) , Exposure, carcinogens, Puolic health, Risx , Food, Experimental data Identifiers: *water pollution effects (Humans) , *Water pollution ef facts ( Animals) , *Ioxic substances, *3thylene/chloro, CAS /b-ui-4, Clean Water Act, environmental health. Maximum permissiole exposure. Health risks. Pharmacokinetics, WII3EPA0WP n3-292 446/2ST h'TIS Prices: PC AOb/MF A0i BO & Environmental Monitoring Near Industrial Sites: Broroinated Chemicals. Part II: Appendix Research Triangle Inst., Research Triangle Park, NC.^Environmental Protection Agency, Washington, DC. Office of Toxic Substances. (304 400) Final rept. 19 Jul-16 Dec 77 AUTHOR: Pellizzari, F. D.; Zweidinger, R. A.; Erickson, M. F0144H3 Fid: 7D, 68, 99A GSAI7902 Jun 78 165p Contract: EPA-68-01-1978 Monitor: EPA/560/6-78/002A See also Part 1, P3-286 484. Also available in set of 3 reports PC E13, PB-286 482-SET. D. Abstract: Contents: Analytical protocols--(scanning electron microscopy and energy dispersive x-ray analysis; total bromine and chlorine by neutron activation analysis: analysis for ethylene in ambient air; sampling and direct analysis for methyl chloride and methyl bromide in ambient air; sampling and analysis for methyl chloride, methyl bromide, vinyl chloride and vinyl bromide in ambient air; sampling and analysis for chlorinated and brominated hydrocarbons and other chemicals in ambient air; chlorine/bromine sampling and analysis in ambient air; determination of inorganic fluoride in ambient air; acid mist sampling in ambient air; sampling and analysis of volatile halogenated hydrocarbons in soil, sediment, water, vegetation and milk; sampling and analysis of semi-volatile halogenated hydrocarbons in air, soil, sediment, water and biota; ozone measurements); Atmospheric dispersion modeling; Meteorological data; Hourly ozone concentrations in El Dorado, Arkansas. R&S 006071 Descriptors: ^Environmental surveys, ^Chemical analysis, ^Bromine organic compounds, ^Bromine inorganic compounds. Halogen organic compounds. Neutron activation analysis, concentration (Composition), Monitoring, Atmospheric diffusion. Industrial wastes. Air pollution. Sites, Ozone, Arkansas, Water pollution. Soil analysis. Sediments, Sampling, Laboratory equipment. Food analysis. Fluorides, Vinyl chloride, Chloromefhanes. Ethylene, Electron microscopy, X ray analysis. Chlorine, Bromine Identifiers: "et.hane/bromo, NTISEPACTS El Dorado (Ark* nsas) , Ethylene/brono, PB-286 483/3ST NTTS prices: PC aOR/MF A01 Investigation of Standards, Performance Characteristics and Evaluation Criteria for Thermoplastic Piping in Fesidential Plumbing Systems National En gineerin g Lab- ( NDS) , washing ton, D. C. * Dep art.ment o f Housing and Urban De vel opmen t, Was h ington, P-C- Assistant Se(cret a ry for Policy Developme nt and Hese;arch- Building Science Ser ies (Final) AUTHOR: ffyly, R- S.; Parker, W- J-; Pierce, g- T Rorrer, P. ?* * * Shaver, J. P.- S2245J3 Fid: 13B, 13K, 89E*, R9G, 94 GRA17821 May 78 153p* Rept No: NBS-B3S-111 Project: NBS-4624 190 Monitor: 18 Library of Congress Cat alog Can3 no. 78-600037. Sponsored in part bv Departme nt of Hous ing and U:cban Development, W ashington. D -C. Assistant Secretary for Policy 'Development and Fes ea rch. Abstract: The application of the performance concept to the evaluation of piping systems of innovative materials is explored- User needs are considered and several material-related physical parameters are studied that might be used as measures of satisfaction of the user needs- Information was reviewed on usage, performance characteristics and standards for thermoplastic pipe and fittings, and special laboratory tests were made to study selected characteristics and test methods- A number of performance statements and evaluation methods are recommended or discussed that relate to characteristics associated with polyvinyL chloride (PVC) , acrylonitrila-hutadiene-styrene (A3S ) and chlorinate! polyvinyl chloride (Cpvc)- This approach was taken to illustrate the application of performance evaluation methodology t plumbing materials. Descriptors: *Plastic pipes, *Plumbing, Residential buildings. Performance evaluation. Thermoplastic resins. Polyvinyl chloride, ADS resins. Piping systems. Acoustic properties. Fire safety. Toxicity, Shock resistance. Dimensional stability, Utilization, Standards Identifiers: NTISCOMNBS PB-282 <*95/157 NTIS Prices: FC A08/MF A01 Hazard Evaluation and Technical Assistance Feport No. TA 77-58, King Soopers, Inc-, Colorado Springs, Colorado national Inst, for Occupational Safety and Health, Cincinnati, Hazard Evaluations and Technical Assistance Branch - APT KO?: Gunter, Bobby J. E1355B2 Fid: 6J, 6T, 570, 57Y, 94D, 68G 1PAI7814 Aug 77 9p Hept No: NIOSH/TF/TA-77/58 Monitor: 18 Ohio. Abstract: A Hazard Evaluation and Technical Assistance survey was conducted by NIOSH on June 23, 1977, at the King Soopers Inc., Denver, Colorado. The survey was prompted by a request from the management regarding the concern of 6 'affected* employees about possible overexposure during the burning of polyvinyl chloride wrap. Based on the results of air sampling which failed to reveal the presence of detectable levels of polyvinyl chloride decomposition products in the breathing zone of the 4 workers present during the survey, it appears that a toxic situation did not exist at the time of evaluation. Three of the 6 employees did complain of upper respiratory irritation caused by fumes coming from the hot wire used to cut the polyvinyl chloride film. Cue worker was on workmen's compensation due to overexposure to fumes from the plastic wrap. Fecommendations are made for improving working conditions and preventing potential exposure. Descriptors: ^Hazardous materials, ^Industrial medicine, *Food industry, *Polyvinyl chloride, vinyl chloride resins. Toxicity, Criteria, Inspection, Standards, 3. econ mendations, Industrial hygiene. Concentration (Composition) , Medical examination. Environmental engineering. Environmental surveys. Food packaging. Packaging material , Air pollution, Pespiratory system, Colorado Identifiers: *Toxic substances, *Dccupat.ional safety and health. Threshold limit values. Maximum permissible exposure level. King Soopers Incorporated, Air sampling, Colorado Springs(Colorado), NTIS HZWOSH 20-278 964/2 ST NTI5 Prices: PC A02/MF A01 JJ C CO co o CO o -vl CO 3. Organic Chemicals in Occupational and Experimental Carcinogenesis (Excluding Host Pclycyclic Hydrocarbons Nitrcso Compounds) National Cancer Inst., Eethesda, Md. International Career Research Ea^a Ear.k. Special listing. ECU^tJA2 Fid: 6 E , 6J, 510*, 25 Mcv 77 41p` Rept Kc: NCI/ICE E E/SL-7 6/57 Monitor: 18 57(J GEAI7805 Abstract: The Special Listing of Current cancer Research Projects is a service of the International Career Research Data Ear.k (ICSEB) program cf the National Cancer Institute. Pach listing contains descriptions of ongoing projects in one selected cancer research area. This listing includes research areas in: Cancer risk associated with occupational exposure to specific organic chemicals; carcinogenic effects and metabolism cf arc Ayes, arylaraines and other isccyclic aromatic hydrocarbon derivatives in animal models; carcinogenicity and metabolism of aliphatic hydrocarbon derivatives in anim-al models; carcinogenicity testing of ethylene halides and other saturated aliphatic halchydiccarbon derivatives; carcinogenicity and metabolism of heterocyclic compounds in animal medals; and broad programs, and other studies cn chemical carcinogenesis in animal models. Descriptors: `Malignant neoplasms, `Research projects, `Industrial medicine, `Organic compounds. Carcinogens, Metabolism, Vinyl chloride, Chlorchydrocarbcns, Aromatic hydrocarbons, Azo dyes, Arylamines, Aliphatic hydrocarbons. Halides, Ethylenes, Halchydrocarbons, Heterocyclic compounds Identifiers: `Listings, `Cancer , `Medical research, `carcinogenesis. Health risks, Et her/Ch leremet hy 1, NUSNIHICS NTISUE/C/296-00 4 NTIS Frices: FC A0 3/MF AC 1 4 R&S 006074 R&S 006075 A Cress-Sectional Hpidemiclooic Survey cf Vinyl Chloride workers f^^fc-onal Inst, for Occupational Safety and Health, Cincinnati, Ohio. cf Surveillance, Hazard Evaluation and Field Studies. **Bureau of Epide tr i clcq y, Atlanta, Ga. Cancer and Birth Defects Di v, **North Carolina Or.iv. at chapel Kill, N.c. Cccupatior.sl Health studies Group. **Mcnteficre Hospital, Pittsburgh, a. Dept, of Medicine. ADTHCF.: Waxveiler, Richard J,; Falk, Henry; McMichael, Anthony; Mallcv, .Joseph S. ; Grivas, A. Scott HC32UK2 Fid: 6J, 570, 94D, 66G Jun 77 SOp GPAI78C4 Monitor: DHEW/POE/NICSH-77/177 Prepared in cooperation with Bureau of Epidemiology, Atlanta, Ga. Cancer and Eirth Defects Div,, North Carolina Oniv. at Chapel Hill, M.C. Occupational Health Studies Group, and Montefiore Hospital, Pittsburgh, Fa. Dept, cf Medicine. Abstract: The extent tc which vinyl chloride monomer induces clinical detectable abnormalities among workers cccupationally exposed was investigated during a cross-secticr.al medical survey at a chemical plant which had a polyvinyl chloride polymerizaticn operation, a polyvinyl chlcride fabrication operation, and a rubber tire production operation. The survey of 433 predominantly white male employees, divided into four vinyl chlcride exposure groups (never, light, heavy, former), determined the prevalence of illnesses and abnormalities based on data gathered by interview, medical examination, blood and pulmonary function tests, liver scans, and hand and chest x-rays. Age-adjusted analyses indicated that hepatomegaly, central nervous system symptoms, diastclic hypertension and spouses' fetal wastage (the latter two statistically significant) were mere prevalent among past cr present vinyl chloride exposed workers than among controls. 7her^ was r.c excess of respiratory system problems, acroosteolysis, Raynaud's phenomenon, and chromosome aberrations as compared with industrial worker controls. Descriptors: *cccupatior.al diseases, ^Industrial medicine, *Vinyl chloride, ^Chemical industry, *Rubbar industry. Polyvinyl chloride. Epidemiology, Liver diseases. Nervous system disorders, Hypertension, Fregrancy complications. Abortion, Toxicity, Chlorchvdrocarbons Identifiers: Health surveys, Occupational safety and health. Environmental health, NTISHEWOSH PE-274 193/2 ST NTIS Prices: PC AC 3/M F AC 1 R&s 00607ft Health Hazard Evaluaticr/Tcxicity Determination Peport 76-65-348, Sheller-Globe Corporation, Union City, Indiana. Hardy Division National Inst, for Occupational Safety and Health, Cincinnati, (3 90 766) A.UTHCE: Salisbury, Stanley A. EC 25 214 Eld: 6J, 6T, 57U, 57Y, 94D, 68G, 68A GBAI78Q3 Dec 76 9p Kept No: NIOSH-TP.-HHE-76-65-348 Monitor: 18 Ohio, Abstract: A health hazard evaluation determination performed by NICSH or. July 12 and 13 , 1976, at the Hardy Division of the Sheller Glebe Corporation in Union City, Indiana revealed that employees working with or near the polyvinyl chloride injection molding process are not exposed to detectable levels of vinyl chloride vapers, The deteririraticn was based cn direct measurements and collected air samples taken during both normal and purging operations of an injectir.g melding machine. Hydrogen chloride, a thermal decomposition product of polyvinyl chloride, was also not detected during the injection melding operation. Descriptors: ^Thermoplastic resins, Hazardous materials, *Industrial medicine, *Envircr.mental surveys, Vinyl chloride, Hydrcgar. chloride, Polyvinyl chloride, plastics industry, Tcxicity, industrial hygiene, Tcxicclcqy, Evaluation, Inspection, Air pollution, Heccraraendations, Criteria, Vapors, Holding techniques. Interviews, Chlerchydrocarbons. Vinyl resins Identifiars: Environmental health. Air sampling. Toxic substances, Occupational safety and health, *Air pollution effects (Humans), Sheller-Globe Corporation, Union city (Indiana) , NTISHEWOSH PP-273 S25/8ST VTIS Prices: PC AC2/MF AC 1 6 R&S 006077 Thermal stability and Toxicity cf Fclymers: Polypbosphazar.es Pittsburgh (Tr.iv Ea Eept of Metallurgica3 and Materials Engineering 2 2 u i) ( Master's thesis AU7HCE: sebata, K.; Magill, j. H.; EC225F4 Fid; 111, 6T, 710, 57Y 4 Nov 77 46p R<=pt No: SETFC-MME-77-109, TP-1 Contract: NOPC14-77-C-C31C Monitor: 18 Maris, Y. GSAI78C3 Abstract: The tcxicity of thermal decomposition products (in air) of polyaryloxyphcsphazer.a and pclyflucrcalkcxythosphazane was evaluated in terms cf their sensory irritation stress index (S.I.S.I.) using mice to ascertain certain adverse physiological effects. The results are compared with some other polymeric materials (cf commercial interest) that have already been investigated elsewhere. A comparison of all these data shows that the hazard rating for the thermal decomposition products of PTFE, PVC-A (PVC resin; 45.5%, phthalate plasticiser; 32%, filler (CACC3); 5-0.5%, FVC-C (PVC resin: 92%, filler: 2%), polyflucrcalkcxyphcsphazene, polaryloxyphosphazer.e based on the S.I.S.I. was found tc be PTPE greater than vc(A), PVC-C, greater than polyfluoralkcxyphcsphazene greater than pciyaryloxyphosphazer.e. Thermogravimetric and differential thermogravimetric analysis were made cn these two pclyphcsphazene resins in a nitrogen atmosphere at different heating rates. The cclyflucrcalkoxyphosphazene decomposed with a single activation energy of 39.8 kcal/mole leaving nc residue, whereas the polyalkoxyphosphazene exhibited tvc processes with activation energies of 37.7 kcal/mole and 23.7 kcal/mcle respectively. The latter also left a substantial residue which can be associated with its improved behavior over the flucrc-material. (Author)' descriptors; Phcsphazene, decomposition. Fhthalates, Nitrcgen *Flastics, ^Thermal degradation, *Toxic hazards, Senses (Fhysiolcgy) , Irritation, Mica, Polymers, Thermal stability, Flammafcili4- y, polyvinyl chloride, Plasticizers, Fillers, Thsrmogravitret ric analysis, Identifiers: *Pcly(arylcxyphosphazene), *Fcly(flucroalkox yphosDhaz en s) , NTTSCCDXA A C- A C u 6 776/7ST NITS Prices: EC A03/KF AC 1 7 eal-1-}! Hazard I valuat ion/Toxi city net erm inaticr. Report 76-28-332, elcfc Plastics and Manufacturing Company, Columbus, Ohio laticral Inst, fcr Occupational Safety and Health, Cincinnati, (390 766) AnTHOP: Geiss^rt, J. 0.; Herbert, J, D3161A4 Fid: 6J, 6T, 57U, 577, 94D, 68G GRAI7720 Sen 76 25p Rept Ko: NICSH-TF-75-28-332 Monitor: 18 Ohio. Abstract: Exposures of employees tc chemical agents at a molding operation cf the Welch Plastics and Manufacturing Company in Columbus, Ohio, were r.ct found to be toxic under the conditions observed by the national Institute for Occupational Safety and Health (NIOSH) hazard evaluation personnel. Worker exposures tc benzene, bis-chlorcmethyl ether, 2,6-ditert-butyl-p-cresol, carbon monoxide, formaldehyde, hydrogen chloride, hydrogen cyanide, particulates, phthalates, styrene and vinyl chloride ware determined by personal and area air sampling. The workers experienced upper respiratory and eye irrigation associated with the use of a regrcund. polyvinyl chloride and acrylcnitrile-butadiene-pclys+yrne material. The use of this material has been discontinued. Descriptors: *Hazardcus materials, ^Industrial medicine. Particles, Hydrogen cyanide. Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres. Exposure, Respiratory system, Fya (Anatomy), Fsspiratcry infections. Personnel, Benzene, Cresols, Carbon monoxide, Formaldehyde, Hydrogen chloride, Phthelates, Styrene, vinyl chloride Identifiers: Plastics industry, Occupational Safety and Health Act of 1970 , *Toxic substances, Columbus (Ohio), Air samplir.q. Threshold limit values. Maximum permissible exposure leval. Ether/ch lorome th yl, MTIS PESOSE PB-269 11 1/1ST FITS Prices: PC A02/MF AC 1 ^uuu b ya 8 R&S 006079 Toxicity of Plastic Combustion Products. Toxicological Methodologies c Assess the Relative Hazards of Thermal Decomposition Products i^lymeric Materials from Pittsburgh Or.iv. , Ps. Graduate School cf Public Health. *Mat ional Eureau of Standards, Washington, U.C. (2?u 15C) Special rept. AUTHOR: Alarie, Y.; Barrow, S. D279UI4 Fid: 6T, 57Y, 68G Feb 77 313p Grant: HBS-5-9C05 Monitor: NES-GCE-77-8 5 C. GFAI7716 Abstract: Senscry and pulmonary irritation effects of thermal degradation products from natural and synthetic materials were studied using mice. Mice were used to develop a sensory irritation stress index based or. changes in respiratory rate. In addition, acute lethality was obtained. Dcse-respcnse curves were generated for decomposition products from Ccuglas Fir, PVC, flexible polyurethane, teflon, and fiberclas reinforced polyester. Similar data were obtained for CC, CC2, low C2, acrolein, FCl and C12. Preliminary studies on the pulracr.ary effects of combustion products using rabbits are also reported. Descriptors: *Plastics, *Toxicity, *Hazardcus materials, *Corabustion products. Inhalation, Chlorine, Hydrogen chloride. Toxicology, Methodology, Mice, Laboratory animals. Experimental data. Pyrolysis, Exposure, Tables (Cata) , Polymers, lethal dosage, Eioassay, Rabbits, Polyvinyl chloride. Polyurethane resins, Tetraf luorcet hyler.e resins. Fiberglass reinforced plastics. Polyester resir.s. Carbon monoxide. Carbon dioxide, Cxygen, Acroleins, Douglas fir wood Identifiers: Toxic substances. Animal models, NTTSCCMNES PE-267 23 3/5 ST NIIS Frices: PC Aiu/MF AO 1 9 Registry of Toxic Effects of Chemical'Substances. 1976 Edition Tracer Oitcc, Ire., Rockville, Md.* National Inst. for Occupational Safety and Health, Rockville, M d. (408 825) Annual rapt. AUTHCF: Christensen, Herbert E.; Eeniora .; Levis, Richard J. Sr E265UA3 Fid: 61, 6J, 57Y*, 57U, Jun 76 1358p* Contract: DHEW-2 1C-75-CC34 Mcnitcr: NTCSH-76/191 Snpersedas PE-246 557. Fairchild, Edvard J. ; Carroll, 68G*, 44G, 94D* GFAI7715 Abstract: The 1976 edition of the Fegistry of Toxic Effects of Chemical Substances, formerly referred +0 as the Tcxic Substances List, is prepared annually by the National Institute for Occupational Safety and Health (NIOSH) in compliance with the Occupational Safety and Health Act cf 1970. The* 1976 REGISTRY contains some 82,908 listings cf chemical substances; 5, 228 mere than the 1975 edition. Its purpose is tc provide basic information cn the known toxic and biological effects of chemical substances for use cf employers, employees, physicians, industrial hygienists, toxicologists, researchers, and in general, all concerned with safe handling of chemicals. The absence cf a substance from the REGISTRY does not indicate that it is not toxic. Drugs cr therapeutic chemicals in the REGISTRY have been included if they have been reported tc produce a noxicus effect. Descriptors: ^Toxicology, *Cheirical compounds, Ird axes ( Document aticn) , Public tea-lth, Dcsage, hygiene. Standards, Chemical properties. Pesticides, Carcinogens, Vinyl chloride. Aquatic Hazardous materials. Toxicity, Industrial Exposure, Asbestos, biology. Regulations Identifiers: *Tcxic substances, *Occupat iona1 safety and health. Maximum permissible exposure level. Occupational Safety and Health Act Cf 1970 , NTISHEH CSH PE-266 295/5ST NTTS Prices: PC A99/MF AC-1 oaa 10 R&S 006081 Heal-h Hazard Evaluation/Toxicity Determination Report Number 75~166-309, Water Well Drilling Companies, Western Tennessee ^-rional Tnst., for Occupational Safety (3 9 C 766) AUTHCF: Gilles, D. ; Hatch, L. C2C82K2 Fid: 6 J, 6T, 57U, 57Y, 9HD, Jul 76 ICp Pept No: NIOS H- ?R- 7 5 - 1 6 fi- 20 9 Mcr.itcr: 18 and Health, Cincinnati, 68G, "4G GRAI7711 Ohio. Abstract: or. the basis of medical and environmental data collected at the Water Well Drillers in Western Tennessee, the use. cf polyvinyl chloride (PVC) cement is not found to constitute a health hazard under existing conditions cf use. Environmental samples show only low levels of tetrahydrofuran and no detectable levels cf cyclohexanone. Responses he medical questionnaires indicate no symptoms associated with exposure tc the chemicals. Descriptors: *Pclyvinyl chloride, medicine, Wells, Erillinq, Cements, hygiene, Er.vir cnmsntal surveys. Cyclohexanones, Tcxicclcgy *Hazardous materials, ^Industrial Industrial atmospheres. Industrial Sampling, Chlor ohydrocar tens. Identifiers: *Toxic substances. Occupational Safety and Health Act of 1 970 , NHSHEWCSH EE-2 63 859/ 1ST NTIS Prices: PC AC2/MF A01 1l Research Frcacam on Hazard Priority Ranking of Manufactured chemicals (Chemicals 21-4C) Stanford Research Inst., Menlo Park, Calif.^National science Foundation, Washington, D.C. Research Applied to National Needs. ( 332 SCO) Final rept. on Phase 2 AUTHCR; Brcvn, S, I.; Chan, F. Y.; Jones, J. L.; Liu, D. K. E . 165512 Fid; 7S, 6T, 6SH*, 66, 99B+, 57Y* G RAT 77C8 Apr 75 19 5p* Project: SRI-ECO-3386 Monitor : NSF/PA/E-190B See else FE-263 161 and PE-263 163. E. ; McCaleb, Abstract: Ir. Phase II of this two-phase effort, 8C chemicals having the greatest potential for environmental effects were studied. Information was collected on the extent of the exposure of the environment to these chemicals (during manufacture and use) and on the possible environmental effects cf this exposure (chemical, physical, and biological properties, persistence, and toxicity). The chemicals studied in this volume are as follows: Benzene (chemical uses). Silicone fluids. Nitrobenzene, Tclue nediisocyar.ate (TDI), Xylenes - mixed total. Aniline, Cimethyl terephthalate, Trichlcroflucrcmethane , p-Dichlorcfcenzene, Eithicbis (benzcthiazcle), c-Cichlorobenzene, Tetrabrcmoethane , Methylene (bis) -2-chlcroanilir.e, Polyhalogenated biphenyls (Aroclor 125N), Tricresyl phosphate. Fluorescent brightening aasr.ts (no. 28) , Polyviryl chloride. Methylene chloride, Diehlcropropens, Dichloroprcpane mixture, and Ethyl chloride. (Portions of this document are not fully legible.) Descriptors: *Hazardous materials, *Chemical industry, *Environmsntal impacts, *Orqaric compounds, Manufacturing, Utilization, Chemical properties, Physical properties. Toxicology, 3ioassay, Public health, Tables (Data), Releasing, Air pollution. Water pollution, Chemical analysis. Soil analysis, E*nzer.e, Silicones, Nifrobeczsnes, Xylenes, Aniline, Biphenyl, Polyvinyl chloride, Chlcroethar.es, Fluorescence, Optical brighteners. Industrial wastes, Haloqsn organic ccmrcunds Identifiers: Met hana/trichlorc- flucro, Bsnzene/dichlcrc, Ethar.e/tetr a- bromc, Arcclcr 125h, Prcpar.e/dichlo to, Methylane/chlorc, Isccyar.ic acid/(Met hy lphenyl en e-est er) , Terephthalic acid/ (Dimethyl-ester), Eer.z ct h iazole thicls. Aniline/ N-F-bis (Chlcrcma th yl) , Phosphat e/tricre- syl, NT IS NS F F A, NTISSRI PE-263 162/CST NTIS Prices: PC AC9/MF AC 1 R&S 006083 Research program cn Hazard Priority Ranking of Manufactursd chemicals (Chemicals 1-20) Stanford Research Inst., Menlo Park, Calif.*Naticra1 Science Foundation, Washington, D ,C. Research Applied to National Needs. { 332 SCO) Final rept. cn. Phase 2 AUTHCF: Ercwn, S. L. ; Chan, F. Y.; Jones, J. L. ; liu, D. K. H. E16 55II Fid: 7, 6T, 68H*, 68, 99B*, 57Y* GBAI77C8 Apr 75 196p* Project: SRI-ECU-3386 Monitor: NSF/RA/E-75/1SCA See also EB-263 162. E. ; McCaleb, Abstract: In Phase II of this twc-phase effort, 8C chemicals having the oreatest potential for environmental effects were studied. Information was collected on the extent of the exposure of the environment tc these chemicals (during manufacture and use) and on the possible environmental effects cf this exposure (chemical, physical, and biological preparties, persistence, and toxicity). A questionnaire survey cf industry was conducted to determine the amount and types cf losses in the manufacturing plarts. Information from this survey is tabulated. The following summary reports are submitted fer each of the 8C chemicals: (1) A flow diagram shewing industrial data on the amounts used for various applications: (2) A one-page assessment cf the data gathered cn tcxicolcgy and environmental persistence; (3) A computer printout cf a tubular summary cf the important data gathered; and (U) Copies cf the 25 most pertinent abstracts found in the area cf tcxicclcgy. The report is divided into five volumes; included in this volume are chemicals 1-20. (Portions cf this document are not fully leqible.) Cescriptors: *Hazardcus materials, *Chemical industry, ^Environmental impacts, *crganic compounds, Manufacturing, Utilization, Chemical properties, physical properties, Tcxicclogy, Bioassay, Public health. Air rcllutior. Tables (Data) , Releasing, vinyl chloride, Crescls, Ethyl benzene, Vinylidene chloride, Toluene, Carbon tetrachloride. Water pollution. Soil analysis. Chemical analysis, Dichlor edi f lucrcmethar.e , Tc*raethyl lead, Chlorine aliphatic compounds. Industrial wastes, Fh^r.cls, Hale gen compounds Identifiers: Nonanals, Benzopyrenes, Benzene/hexachloro, Ethylene/tricHorc, Ethana/trichlcro, Eth ylene/chloro , phosphorium chloride/tetrakis (Hydroxymethyl), Putadisr.e/hexachlorc, Ethyler. e/dibr- om.o, Ethyler.e/dichlorc , P hes phat s/t r is (Pibr one pr c p yl) , N TI $ S F. I NTISNSFFA, PE-263 161/2ST NTIS Prices: PC A09/MF A01 13 R&S 006084 Research Program on Hazard Priority Ranking of Manufactured Chemicals (Chemicals 21-40) Stanford Research Inst., Menlo Park, Calif.*National Science Foundation, Washington, D.C. Research Applied to National Needs. ( 332 50C) Final rept. on Phase 2 Brown, S. L., Chan, F. Y., Jones, J. L., Liu, D. H., McCalab, K. E. D1655I2 Fid: 7A,- 6T, 68H*, 68, 99B*, 57Y* GRAI77C8 Apr 75 195p* Project: SHI-ECU-3386 Monitor: NSF/HA/E-190B See also PB-263 161 and PB-263 163. Abstract: In Phase II of this two-phase effort, 80 chemicals having the greatest potential for environmental effects were studied. Information was collected on the extent of the exposure of the environment to these chemicals (during manufacture and use) and on the possible environmental effects of this exposure (chemical, physical, and biological properties, persistence, and toxicity), the chemicals studied in this volume are as follows: Benzene (chemical uses). Silicone fluids. Nitrobenzene, Toluenediisocyanate (TDI) , Xylenes - mixed total. Aniline, Dimethyl terephthalate, Trichlorof luorome thar.e, p-Dichlorobenzene, Dithiobis (benzothiazola) , o-Dichlorobenzer. e, Tetrabromoethane. Methylene (bis)-2-chloroaniline, Polyhalogenatea' biphenyls (Aroclor 1254), Tricresyl phosphate. Fluorescent brightening agents (no. 28), Polyvinyl chloride. Methylate chloride, Dic'nloropropene, Dichloropropane mixture, and Ethyl chloride. (Portions of this document are not fully legible.) Descriptors: *Hazardous materials, ^Chemical industry, * Environmental impacts, Organic compounds. Manufacturing, Utilization, Chemical properties. Physical properties, Toxicology, Bioassay, Public health, Tables (Data) , Releasing, Air pollution. Water pollution, Chemical analysis. Soil analysis. Benzene, Silicones, Nitrobenzenes, Xylenes, Aniline, 3iphenyl, Polyvinyl chloride, Chloroethar.es, Fluorescence, Optical brighteners. Industrial wastes. Halogen organic compounds Identifiers: Methane/trichloro-f luoro, Benzene/dichloro, zthar.e/t etr a- bromo, Aroclor 1254, Pro pane/dichloro, Methy ler.e/chlcro, Isocyamc acid/(Methylphenylene-ester), Terephthalic acid/(Dimethyl-ester), Benzothiazole thiols, Aniline/N-N-bis (Chloromethyl) , Phosphate/tncr s- syl, NTISNSFRA, NTISSRI PB-263 1 62/0 ST NTIS Prices: PC A09/MF A01 I4 Research Program on Hazard Priority Ranking of Manufactured Chemicals (Chemicals 1-20) Stanford Research Inst., Menlo Park, Calif.^National Science Foundation, Washington, D.C. Research Applied to National Needs. ( 332 500) Final rept. on Phase 2 3rown, S. L., Chan, F. Y,, Jones, J. L., Liu, D. H., McCaleb, K. E. D1655I1 Fid: 7A, 6T, 68H*, 68, 99B*, 57Y* GRAI7708 Apr 75 196p* Project: SRI-ECU-3386 Monitor: NSF/RA/2-75/190A See also PB-263 162. Abstract: In Phase II of this two-phase effort, 80 chemicals having the greatest potential for environmental effects were studied. Information was collected on the extent of the exposure of the environment to these chemicals (during manufacture and use) and on the possible environmental effects of this exposure (chemical, physical, and biological properties, persistence, and toxicity). A questionnaire survey of industry was conducted to determine the amount and types of losses in the manufacturing plants. Information from this survey is tabulated. The following summary reports are submitted for each of the 80 chemicals: (1) A flow diagram showing industrial data on the amounts used for various applications; (2) A one-page assessment of the data gathered on toxicology and environmental persistence; (3) A computer printout of a tubular summary of the important data gathered; and (4) Copies of the 25 most pertinent abstracts found in the area of toxicology. The report is divided into five volumes; included in this volume are chemicals 1-20. (Portions of this document are not fully legible.) Descriptors: ^Hazardous materials, *Chemical industry, ^Environmental impacts, *Organic compounds. Manufacturing, Utilization, Chemical properties. Physical properties. Toxicology, Bioassay, Public haaltn. Air pollution. Tables(Data), Releasing, Vinyl chloride, Cresols, Ethyl benzene, Vinylidene chloride. Toluene, Carbon tetrachloride, Water pollution, Soil analysis. Chemical analysis, Dichlorodifluoromethane, Tetraethyl lead. Chlorine aliphatic compounds, Industrial wastes, Phenols, Halogen compounds Identifiers: Nonanals, Benzopyrenes, Ber.zene/hexachlorc, Ethylene/trichloro, Ethane/trichloro, Ethylene/chloro, Phosphonium chloriae/tstrakis (Hydroxymethyl) , Butadiene/hexachloro , Ethvlsr.e/dibr- omo, St hylene/dichloro, Phosphate/tris (Dibrcmopropyl) , 'll 15 NS FRA, NTISSEI PB-263 1 61/2ST NTIS Prices: PC AQ9/MF AC 1 R&S 006085 I5 Toxicology of Plastics Having Contact with Blood, Report of Pro,gram. Progress Q) -U R&S 006086 Travenol Labs., Inc., Horton Grove, 111,*Nationa1 Heart, Lung, and Blood Inst., Bethesda, Md. Annual rept. Josephson, A. M. D1503C4 Fid: 6T, 6L, 571, 95C GRAI7707 May 75 22p Contract: NO 1-HB- 2-2990, PHS-72-2990 Monitor: NIH-NO1-HB-2-2990 -- Abstract: Di-2-ethylhexyl phthalate (DEHP) was extracted from polyvinyl chloride (PVC). This material was diluted in sterile rat plasma and used to inject, IV, groups or rats with a 3.7 mg/kg/injection, which is equivalent to the DF.HP dose that a patient would receive from a total exchange transfusion of blood. Growth rates, gross reactions following injections, hematology and serum chemistry parameters, gross organ pathology, absolute and relativ organ weights, histopathology, and residual DEHP levels in plasma an tissues were similar for all groups, including plasma control groups. No toxicology significant changes were observed. Descriptors: ^Toxicology, * Plasticizers, Polyvinyl chloride. Toxicity , Plastics, Medical supplies. Medical equipment, 31ood, Bioassay, Rats , Laboratory animals Identifiers: Phthalic acid/bis (Ethylhexyl-ester) , *3lood compatible materials. Biomaterials, NTI5NIHHLI P B-262 260/3ST NTIS Prices: PC A02/MF A01 Special Listing of current Cancer Research on Carcinogenic Substances in Food and Drugs (Along with Related Epidemiology) Smithsonian Science Information Exchange, Inc,, Washington, D.C. Current Cancer Research' Project Analysis Center.* National Cancer Inst., Bethesda, Md. International Cancer Research Data Bank. D1492F3 Fid: 6H, 60, 6E, 98H*, 57Q*, 57E, 68G* GRAI77Q7 24 Nov 76 28p* Monitor: NCI/ICRDB/SL-76/25 See also PB-261 670. Abstract: ;Contents: Aflatoxins and other organic naturally occurring carcinogens; Oncogenic food additives, residues, and environmental contaminants; Epidemiology cf cancer in relation to diet; Influence of dietary factors on susceptibility to chemical carcinogens in experimental animals; Oncogenic side-effects of drugs. Descriptors: ^Malignant neoplasms, ^Carcinogens, +Foods, *Drugs, Etiology, Diet, Food additives. Pollution, Environments, Mitroso compounds. Amines, Vinyl chloride. Esophageal carcinomas, Breast neoplasms. Chemical compounds. Tolerances(Physiology), Epidemiology, Antineoplastic agents, Reserpine Identifiers: Aflatoxins, Mycotoxins, Biotoxins, Nitroscamines, *Cancer , Environmental health, NTISNIHNCI PB-26 1 671/2ST NTIS Prices: PC A03/MF A01 R&S 006087 Problems of Occupational Hygiene and the State of Health of workers' Employed in Manufacturing Latex Polyvinyl Chloride (Voprosy Gigier.y Truda i Sostoyanie Zdorovya Rabochikh, Zanyatykh na Proizvedstve Lateksnoyo Nolivinilkhlorida) Environmental Protection Agency, Research Triangle park, Translation Services Section. Filatova, V. S., Gronsberg, S. Sh., Smirnova, N. A., Stulova, I. Oreshkevich, I. V, D1345G3 Fid: 60, 6T d7706 1965 lOp Eept Ho: EPA-TR-7 6-366 Monitor: 18 Trans. of Gigiena Truda i Professionalnye Zabolevaniya (USSR) v9 p9- 14 1965. , r.8 Abstract: Pollution of th e air with vinyl chloride and resin dust is possible during the manu facture of late x polyvinyl chloride. Such pollution is caused by disruption of th e seal of equipment and by carrying out certain ope rations manually . During the study of the state of health of the workers, some of them were found to have changes characteristic for the initial forms of chronic vinyl chloride intoxication: slightly pron ounced disorders of the vegetative-vascular regulation, symptoms of v egetative polyneu ritis and thermoregulatory disorders. An improvement in the condit ions, of labor of workers employed in manufacturing latex polyvinyl c hloride can be attained by means of sealing the equipm ant, improving te chnological operations and improving the function of v entilation. Descriptors: *Polyvinyl chloride, ^Industrial hygiene, ^Toxicity, hazardous materials. Health status, Toxic diseases. Manufacturing, Industrial medicine. Translations, USSR, Toxicology, industrj-a1 atmospheres. Recommendations, Pathology Identifiers: Occupational safety and health, "oxic substances, *Air pollution effects (Humans) , NTISEPAISD PB-261 76 4- T/ST HTIS Prices; PC A02/MF A01 R&S 006088 Occupational Vinyl Chloride Intoksikatsii Vinilkhloridom) Intoxication (0 profassionalnoi Environmental Protection Agency, Research Triangle Parle, N.C. Translation Services Section, Antonyuzhenko, V. A. D1345G2 Fid: 6J, 6T d7706 1968 6 p Rept No: EPA-TR-76-365 Monitor: 18 Trans. of Gigiena Truda i Professionalnye Zabolevaniya (USSR) v12 z3 p50-52 1968. Abstract: Cases of acute vinyl chloride intoxication m workers are extremely rare and are usually due to massive exposure to the substance during work in closed areas and during accidents. Under the indicated conditions even short-term breathing of vinyl chloride car. cause sudden loss of consciousness and a state of narcosis. In those cases when the patient is not immediately removed from the gas-filled room, a coma may develop that is lethal as the result of respiratory arrest. With timely rendering of first aid, patients soon emerge from the comatose condition, but consciousness may remain clouded for a short time. over the next few days, headache, dizziness, general weakness and an inclination to bradycardia and arterial hypotony are observed. The patient practically recovers in 5-7 days. Descriptors: Vinyl chloride, Industrial Hazardous materials. Toxic diseases, Translations, Chlorine organic compounds, Industrial atmospheres. USSR, Respiration, Gases hygiene, Toxicity, Chemical compounds, Industrial medicine, Toxicology Identifiers: Occupational safety and health, effects(Humans), Toxic substances, NTISEPAI5D Air pollution P3-261 763-T/ST NTIS Prices: PC A02/MF AO! R&S 006089 19 R&S 006090 Current Awa reness Service for TO xic Substances (CATS). Cumulati Report Number 2. Par t II Little (Arthur D.) , Inc. , Cambr id ge. Mass.*Environmental p rot ecti Agency, Washingt on. D.c. Office of T oxic Substances. (208 8 50) Annual rept. D1 2 4132 Fid: 1 3B, 6?, 68* , 57 Y* GRA 17705 Nov 76 364p* Rapt No: ADL-C-77355-Pt-2 Contract: EPA-68-01-2694 Monitor: EPA/560/7-76/002a Sea also report dated Dec 75, PB-250 075 and Part 1, PB-260 360. Abstract: The scanning topics included in this two part series are :he chemicals and subject areas as follows: Acetonitrile, acrylonitrile, arsenic, aryl phosphates (phenyl, cresyl, mixed phenyl-cresyl), asbestos, benzidine, and salts (hydrochloride, sulfate), boron, brominated biphenyls, dichlcrobenzidine, dioxane, ethyleneimine, flame retardants, fluorocarbons, haloethers, hexachlorobenzene, hexachlorobuzadiene, hydrazine, derivatives, and salts (sym and unsym dimethyl, monomethyl), isocyanates (organic), liquefaction and gasification of coal, methylenebis (chloroaniline) , modal ecosystems (environmental fate testing, microecosystems) , naphthylammes (alpna, beta, N-phenyl derivatives), nitrilotriacetic acid, optical brighteners (fluorescent whitening agents, fluorescent dyes), perchloroethylsne, phthalates (dioctyl, di-2-ethylhaxyl), polyurethanes, propiolactone, trichloroethylene, shale oil extraction and refining, vinyl chloride, vinylidene chloride, ethylene dibronide, and nitrosamines. Descriptors: *Toxicity, *Chemical elements, ^Pollution, Vinylic^^e chloride resins. Acetonitrile, Acrylonitriles, Arsenic, Phospha^B, Cresols, Phenols, Asbestos, Nitrosamines, Lactones, Benzidine, 3or7h, Biphenyl, Dioxanes, Aziridines, Fire resistant materials, Fluorohydrocarbons, Ethers, Halogenorganic compounds. Coal gasification, Hydrazines, Isocyanates, Ecosystems, Amines, Optical brighteners, Phthalates, polyurethane resins, Naphthalenes, Shale oil. Extraction, Refining, Vinyl chloride Identifiers: Diphanyl/bromo, Benzidine/dichloro, Coal liquefaction, Benzene/hexachloro, Butadiene/hexachloro, Aniline/N -N-fcis (Chloromethy- 1), Naphthylamines, Acetric acid/nitrilo-tri, Ethylene/chloro, Ethylene/trichloro, Ethylene/dibromo, NTISEPA0TS P3-26D 361/13T NTIS Prices: PC A16/KF A01 20 Current Awareness Service for Toxic Substances (CATS). Cumulative Report Number 2. Part I Little (Arthur D.), Inc., Cambridge, Hass.^Environmental Protection Agency, Washington, D.C. Office of Toxic Substances. (208 85C) Annual rept. D1241B1 Fid: 133, 6T, 68*, Nov 76 407p* Rept No: ADL-C-77355-Pt- 1 Contract: EPA-68-01-2694 Monitor: EPA/56G/7-76/002 See also Part 2, PB-260 361. 57Y* GRAI7705 Abstract: This cumulative report contains 26 current awareness documents prepared biweekly from 25 August 1975 through 9 August 1976 during the second year of a two year project. The purpose of this project was to provide the Office of Toxic Substances (OTS) , U.S. Environmental Protection Agency with information on new uses of existing chemical products and with information of obvious potential environmental concern for both new and existing chemical products. For each biweekly document a core list of approximately 80 journals was scanned for information of interest to OTS on more than 30 topics (compounds, classes of compounds, and subject areas, e.g., model ecosystems). Abstracts were prepared for all items selected and these abstract's were presented biweekly under the assigned topics. In addition, a 'General Information' section was added to accommodate abstracts for topics not included in the original list of scanning topics. Biweekly subject indexes were cumulated for this annual compilation, and an author index was added. Descriptors: *Toxicity, ^Pollution, Vir.ylidene chloride resins. Acetonitrile, Acrylonitriles, Arsenic, phosphates, Cresols, Phenols, Asbestos, Nitrosamines, Lactones, Benzidine, Boron, Biphenyl, Dioxanes , Aziridines, Fire resistant materials, Fluor ohyd rocarbor. s, Ethers, Halogenorganic compounds, Coal gasification. Hydrazines, Isocyanates, Ecosystems, Amines, Optical brighteners, Phthalatss, Polyurethane resins. Naphthalenes, Shale oil, Extraction, Refining, vinyl chloride Identifiers: Biphar.yl/brcmo, Benzidine/dichloro, Ccal liquefaction, Benzene/hexachloro, 3uta die ne/hexac hlor o , Anilir.e/N- N - bi~s (Ch loro math yi) , Naphthylamines, Acetric acid/nitri lo-tri, Ztn ylene/chloro, Ethylene/trichlcro, Ethylene/dibromo, NTISEFAOTS PB-260 3 60/3 ST NTIS Prices: PC A18/MF A01 2r 30 (/) o o CD o (0 R&S 006092 Th= So-Called Vinyl Vinylchlorid-Krankheit) Chloride Disease i* (Ueber die Sogenannte Environmental Protection Agency, Translation Services Section. Research Triangle Park, N. C. Juehe, 3., Lange, C. -E., Stein, G., Veltraan, G. D034531 Fid: 6J, 6T, 57U, 57Y, 68G GSAI7702 1975 15p Rept No: EPA-TR-75-6 Monitor: 18 Trans. of Deutsche Medizinische Wochenschrift (West Germany) v98 p20 34-20 37 n.d. Abstract: Since the first reports on impairments of health of workers in the vinyl chloride (VC) industry appeared in 1958, and of workers in the polyvinyl chloride (PVC) industry in 1963, attention has been repeatedly directed at this branch of the chemical industry by further reports. A syndrome was observed which was similar in its sxin and bone changes to scleroderma, while its etiology and pathogenesis remained unresolved. Its principal symptom was the Raynaud syndrome -nodose or surface hard skin changes and band-shaped osteolyses of the finger end-phalanges. The first observations of this disease pattern was reported in Germany in 1972. The authors have recently made an exhaustive report on the results obtained through the end of 1972, which reveal new aspects in the assessment of the disease. The most important features are summarized. Descriptors: ^Occupational diseases, *Vinyl chloride, ^Industrial medicine, Integumentary diseases, *Toxicology, Dermatology, Chemical industry. Skin diseases. Signs and symptoms. Gases, Pathology, Pathophysiology, Histology, West Germany, Translations Identifiers: Air pollution effects (Humans), Environmental health^ Occupational safety and health, NTISEPAISD PB-258 8 3 8-T/ST NTIS Prices: PC A02/MF A01 22 Standard Support and Environmental Impact Statement promulgated- Emission Standard for Vinyl Chloride Volume 2. Environmental Protection Agency, Research Triangle Park: H.C. Off of Air Quality Planning and Standards. D0344L3 Fid: 13B, 6J, 6F , 7A, 68H, 68, 68A, 57U, 57 H G RA1770 2 Sep 76 135d Rept No: EPA/450/2-75/009b Monitor: 18 See also PB-249 703. Abstract: A national emission standard for vinyl chloride emitted from ethylene dichloride-vinyl chloride and polyvinyl chloride plants is being promulgated under the authority of section 112 of the Clean Air Act. Vinyl chloride has been implicated as the causal agent of angiosarcoma and other serious disorders, both carcinogenic and noncarcinogenic, in people with occupational exposure and in animals with experimental exposure to vinyl chloride. Reasonable extrapolations from these findings cause concern that vinyl chloride may cause or contribute to the same or similar disorders at present ambient air levels. The purpose of the standard is to minimize vinyl chloride emissions from all known process and fugitive emission sources in ethylene dichloride-vinyl chloride and polyvinyl chloride plants to the level attainable with best available control technology. This would have the effect of furthering the protection of public health by minimizing the health risks to the people living in the vicinity of these plants and to any additional people who are exposed as a result of new construction. This is estimated to have the effect of reducing emissions from a typical ethylene dichlor ids-vir. yl chloride plant by approximately 94 percent and from a typical polyvinyl chloride plant by approximately 95 percent. This document contains a summary of the public comments on the proposed standard ana EPA's responses to the comments. It also contains updated information concerning the environmental and inflationary impacts of the standard. Descriptors: *Air pollution control, ^Environmental impact statements, *Vinyl chloride, ^Hazardous materials, Chemical plants, Cost analysts. Economics, Public health. Industrial wastes, Combustion products, Lav enforcement. Standards, Industrial hygiene. Particles, Waste water, Water pollution. Pesticides, Aerosols, Testing, Toxicity Identifiers: Fugitive emissions, Air quality, NTISEPAAWF. PB-258 827/5ST NTI5 Prices: PC A07/KF A01 R&S 006093 23 R&S 006094 Ch ft Evaluation of Vinyl Chloride Emissions in the Long 3sach Area, California National C7694A3 May 74 Bept No: Monitor: Field Investigations Fid: 133, 68A, 68D 47p EPA/330/2-74/0C2 18 Center, Denver, GHAI7625 Colo. - Abstract: A survey of vinyl chloride emissions from the American Chemical Corporation and B.F. Goodrich Chemical company showed the vinyl chloride monomer was leaving the plants via water, sludge, an air as well as in the final product, polyvinyl chloride. It is estimated that about 2.3 kg (5 lb)/day of PVC leave the 3.F. Goodrich plant, and 10 kg (22 lb)/day leave the American Chemical plant in the wastewater effluents. Smaller quantities were found in the sludge. The report presents a plant evaluation and a sampling program. Descriptors: *Pollution, *Vinyi chloride, *Polyvinyl chloride. Surveys , Water pollution. Sludge, Air pollution. Infrared spectrometers. Evaluation, Industrial plants. Toxicity, Environmental impacts. Safety , Public health, Assessments, Sampling, California Identifiers: Long Beach(California), NTISEPAO P3-257 642/9ST NTIS Prices: PC$4.00/MF$3.00 "24 Toxicity of the Pyrolysis Products of Spacecraft Materials Tennessee Univ., Memphis. Annual Report, 1 Aug. 1974 - 31 Jan. Lawrence, W. H. C6915C3 Fid: 06T, 223, 57Y, 84A 29 Mar 76 79 Rapt No: NASA-CR-147563, AR-2 Contract: NAS9-13617 Monitor: 18 1976. STAR1413 Abstract: Data is presented which provides guides to (1) approximate temperature necessary to initiate thermodegradation of the polymeric materials tested, (2) the relative toxicity of thermodegradation products from the various materials, (3) the relative importance of carbon monoxide as the primary cause of death (as contrasted to cyanide or other toxic gases), and (4) whether or not the hazards of the fumes are confined to the time of exposure, or whether post-exposure death is likely. Two different experimental methods were employed. (Author) Descriptors: ^Combustion products, ^Pyrolysis, *S?acecraft construction materials, ^Toxicology, Carbon monoxide. Car boxyhemoglobin, Nylon (Trademark), Polyimides, Polyvinyl chloride. Rats, Thermogravimatry, Urethanes Identifiers: NTISNASA N76-22887/3ST NTIS Prices: PCS 5.00/MFS2.25 R&S 006095 25 Sampling and Analysis of Selected Toxic Substances. Task III. Vinyl Chloride, Secondary Sources Midwest Research Inst., Kansas City, Mo.*Ervironmantal protection Agency, Washington, D.C. Office of Toxic Substances. (230 350) Final rept. 1 Nov-31 Dec 75 Going, John E. C6824L2 Fid; 06T, 06F, 13B, 57Y, 57H, 68A, Apr 76 30p Contract; EPA-68-01-2646 Monitor: EPA/560/6-76/002 See also report dated Sap 75, PB-246 213. 68G, 99A GRAI7616 _ Abstract: A sampling and analysis program was conducted to determine whether and to what extent vinyl chloride was present in ambient air due to the presence of polyvinyl chloride products. Sampling environments were chosen to represent real life, but nonworx situations where a significant exposure to polyvinyl chlorida products might occur. A sampling and analysis protocol was developed with a recovery efficiency of greater than 90% and a detection limit of 10 ppb (v/v). The two general categories of environments sampled were vehicles and commercial products. The interior ambient air was sampled from new and used domestic automobiles, foreign automobiles ar.d domestic mobile homes. No evidence of vir.yl chloride was round. The following commercial vinyl products, when sampled m their normal environment, did not produce a measurable quantity of vinyl chloride in the ambient air: vinyl wall covering; vinyl swimming pool liners; and vinyl nursery products. A room being painted with a heavily pigmented red paint was found to contain a very low level of vinyl chloride. Descriptors: *Toxicology, ^Carcinogens, *Vinyl chloride, Air poiluti , Automotive industry. Sampling, Exhaust emissions, combustion products. Public health. Vehicles, Paints, Fabrics, Gas cnromatographv , Gas analysis. Charcoal, Adsorbents, Sites, Sources Identifiers: *Air pollution sampling. Cancer, Environmental health, Secondary sources, NTISEPAOTS JJ fio W P3-252 966/7ST NTIS Prices: PCS4.00/MFS2.25 o o U) o <D 3) 26 Toxicity of Components of Plastic Having Contact with Blood Tra.venol Labs., Inc., Morton Grove, 111.*Nationai Heart and Lung Inst., Bethesda, Md. Div. of Blood Diseases and Resources. Final technical progress rept, Jun 72-Mar 75 Miripol, J. E., Garvin, P, J., Stern, I. J., Wallin, R. F. C6573C3 Eld: 06T, 06L, 57Y, 95C, 95A GHAI7613 Sap 75 34Cp Contract: N01-H3-22990 Monitor: NIH-NO1-HB-22990 Abstract: Method of solubilization, dosage form and route of administration are factors which are critical in the distribution and excretion of di~ (2-ethylhexyl) phthalate (DEHP) , one of the most widely used components employed in the formulation of flexible polyvinyl chloride (PVC). Changes in the apparent volume of distribution of DEHP observed when aqueous suspensions were used for injection of the plasticizer indicated that differences in the systemic disposition and distribution of DEHP were dependent on tne physical state of the dosage form. Valid studies of the biological effects of parenterally administered DEHP must be performed with a dosage form of the plasticizer which is like that encountered in clinical situations. Whole body autoradiographic studies performed or. mice infused with serum containing 14C-DEHP showed rapid accumulation of labeled carbon in the kidney and liver with rapid excretion into urine, bile and intestine. Essentially all the labeled compound was excreted within 24 hours. Rats infused twice weekly for oO days with rat plasma containing DEHP extracted from PVC exhibited r.c toxicologically significant changes when compared to controls. Tissue residue studies in man revealed no relationship between transfusion history and tissue content of DEHP. Copyright National Technical Information Service 1976. Descriptors: ^Plastics, ^Toxicology, *Polyvinyl chloride, Blood, Phthalates, Medical supplies. Plasticizers, Toxicity, Toxic tolerances , Dosage, Bioassay, Rats, Mice, Laboratory animals, Absorption(Biology), Excretion Identifiers: *3lood compatible materials, *BiomateriaIs, *?hthalic acid/bis(ethylhexyl-ester) , NTISNIHHLI PS-251 742/3ST NTIS Prices: PCS10.C0/MF52. 25 Toxicology of Plastic Devices Having Contact with Blood R&s 006098 Utah Univ., Salt Lake city. Dept. of Applied Phar macsutical Sciences.*National Heart and Lung Inst., Bethesda, Md. Final rept, 24 Aug 72-23 Aug 75 Petersen, Robert V., Lyman, Donald J., Roll, David 3., Swinyard, Ewa,,- A. C6282K3 Fid: 06T, 06L, 57Y, 95A, 95C GRAI7610 23 Aug 75 248p Contract: PHS-73-29C8 Monitor: NIH/NHLI-72-6-F See also report dated 1 May 75, PB-244 753. Abstract: The project was primarily concerned with toxicological evaluation of polyvinyl chloride and, m ore specifically, the commonly used plasticizer, di (2-ethylhexyl) pht halate (DEHP). Evaluations are primarily concerned with long range, subtle toxicity potential, although many basic acute and subacut e studies were also conducted, The project is divided into twelve tas ks including an organizational phase, plastic composition studies, acute toxicity studies, tissue culture studies, subacute toxicity studi es, metabolite identification, teratogenic studies, neurologic stud ies, larger animal studies, analyses of human blood exposed to plastics during hospital procedures, and possible statistical analysis of human patients following extensive exposure of blood to plastics. Descriptors: *Polyvinyl chloride, ^Plastics, *Plasticizers, Toxicology, Patients, Tissue culture. Bioassay, Laboratory animals, Pathology, Rats, Heart, Phthalates, Body fluids, Neurology, Mice, Reproduction(Biology), Medical supplies. Mechanical organs. Humans^ Blood Identifiers: *Blood compatible materials, Biomaterials, Phthalic acid/bis(ethylhexyl-ester), Metabolites, NTISNIHHLI P3-250 1 C2/1 ST NTIS Prices: PC$8.00/MFS2.25 Standard Support and Environmental Impact Statement: Emission Standard for Vinyl Chloride Environmental Protection Agency, Research Triangle Park, N.C. of Air Quality Planning and Standards. C6195K4 Fid: 138, 06J, 06F, 68A*, 68, 57U, 57H GF.AI7609 Oct 75 536p* Rapt No: E?A/45C/2-75/009 Monitor: 18 Office Abstract: A national emission standard for vinyl chloride emitted from ethylane dichlorida-vinyl chloride and polyvinyl chloride plants is being proposed under the authority of section 112 of the Clean Air Act. Vinyl chloride has been implicated as the causal agent of angiosarcoma and other serious disorders, both carcinogenic and noncarcinogenic, in people with occupational exposure and in animals with experimental exposure to vinyl chloride. Reasonable extrapolations from these findings cause concern that vinyl chloride may cause or contribute to the same or similar disorders at present ambient air levels. The purpose of the proposed standard is to minimize vinyl chloride emissions from all known process and fugitive emission sources in ethylene dichloride-vinyl chloride and polyvinyl chloride plants to the level attainable with best available control technology. This would have the effect of furthering the protection of public health by minimizing the health risks to the people living m the vicinity of these plants and to any additional people who are exposed as a result of new construction. This is estimated to'have the effect of reducing emissions from a typical ethylene dichloride-vinyl chloride plant by approximately 94 percent and from a typical polyvinyl chloride plant by approximately 95 percent. Environmental Impact and Inflation Impact Statements quantifying the impacts of the proposed standard and alternative control levels are included in the document. Descriptors: *Air pollution control, ^Hazardous materials, *Vinyl chloride, *Environmental impact statements, Cost analysis. Public health. Combustion products. Law enforcement, Standards, Polymerization, Industrial hygiene. Particles, Filters, Incinerators, Absorbers (Materials) , Waste water. Water pollution, Solid waste treatment. Noise reduction, Thermal pollution, Pesticides, Aerosols, Chemical industry. Combustion products, Emission Identifiers NTIS2PA0SD Air quality, Fabric filters. Fugitive emissions, FB-249 703/0ST NTIS Prices: PCS 13.00/MFS2.25 33 CO o o CT> O 2 3 ID (D R&S 006100 Scientific and Technical Assessment Report on Vinyl Chloride and Polyvinyl Chloride Environmental Protection Agency, Research Triangle Park, N.C. Final rept. C6105G3 Fid: 06T, 06J, Dec 75 125p* Rapt No: EPA/600/6-75/00 4 Monitor: 18 Sea also PB-246 820. 13B, 57Y*, 57U, 68G*, 68A, 68D GRAI750 Abstract: Vinyl chloride (VC) is a chemical of widespread industrial and commercial use. Occupational experience and experimental evidence strongly indicate that it is a carcinogen. Additionally, there is experimental evidence that indicates that it may be a teratogen and mutagen. An increased incidence of liver angiosarcoma, excessive liver damage, and acroosteolysis has been reported among VC workers, and the frequency and severity of the liver pathology is related to the length of exposure. The principal route of exposure is thought to be air inhalation. Sources of increased importance for the general population include food and water. Tumors at multiple and diverse sites have been observed in all species of experimental animals tested for carcinogenicity by inhalation and ingestion of VC. In addition to the health effects of VC, this document also considers the sources, distribution, and control technology. Descriptors: *Polyvinyl chloride, Vinyl chloride, ^Toxicology, Industrial medicine. Air pollution. Public health. Liver, Malignant neoplasms. Carcinogens, Mutagens, Water pollution. Food chains, Humans , Laboratory animals. Experimental data. Chemical compounds, Chemical industry Identifiers: *Air pollution effects (Humans), Environmental health. Teratogens, Air pollution control, water pollution ef facts (Humar.s) , NTISEPAORD PB-249 461/5ST NTIS Prices: PCS 5.50/MF$ 2.25 30 Health Hazard Evaluation/Toxicity Determination Report H.H.&. 74-94-253, Armstrong Cork Company, Jackson, Mississippi National Inst. for Occupational Safety and Health, Cincinnati, Ohio. (390 766) Final rept. Dec 74-jul 75 Flesch, Jerome P., Rostand, Robert A. C6104L3 Fid: 06J, 06T, 57U, 94D, 68G Dec 75 16p Rept No: NIOSH-TR-HHE-74-94-253 Monitor: 18 See also PB-249 432. G3AI7608 Abstract: An environmental-medical evaluation was conducted by NIOSH at a plant manufacturing vinyl asbestos floor tiles. Environmental air samples were obtained, medical records were reviewed, and non-directed medical interviews were administered. It was determined that exposure to airborne chrysotile asbestos was in excess of the proposed OSHA standard and that there was a potential for exposure to trace concentrations of airborne vinyl chloride monomer. Worker exposures to other toxic materials were below levels believed to be potentially toxic. Review of medical records revealed no findings suggestive of lung cancer (noting that malignant manifestations of asbestos exposure may take 10-40 years to develop after the exposure has ceased. Descriptors: ^Hazardous materials, *Industrial medicine, *vinyl chloride, ^Asbestos, *Silicon dioxide, ^Limestone, Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene, Industrial atmospheres, Exposure, Barium, Lead (iMetal) , Chromium, Zinc, Titanium, Carcinogens, Interviews Identifiers: *Occupational Safety and Health Act of 1970, *Toxic hazards. Air sampling, Ethane/trichloro, NTISHZWOSH PB-249 433/4ST NTIS Prices: PCS3.50/MFS2.2 5 R&S 006101 Health Hazard Evaluation/Toxicity Determination Report H.'H. 2. 75-81-252/ Artex Manufacturing Company/ Inc., Overland Park, Kansas National Inst. for Occupational Safety and Health, Cincinnati, Ohio. (390 766) Final rept. May-Jun 75 Hervin, Raymond L. C6104L2 Fid: 06J, 06T, 57U, 94D, Dec 75 lip Sept No: NIOSH-T2-HHE-75-81-252 Monitor: 18 See also PB-249 431. 68G GRAI7608 _ Abstract: A health hazard evaluation was conducted by NIQ5H at a plant involved in the silk- screen dyeing of decals onto various textile garments. It was determined that employees in the two main production areas were not exposed to toxic concentrations of vinyl chloride and organic solvents, including 1,1,1-trichloroethane, toluene, xylene, and petroleum naphtha. It was further determined that the clean room operator was exposed to potentially toxic concentrations of organic solvents from cleaning silk screens with an organic solvent containing primarily naphtha. Descriptors: *Hazardous materials, *Industrial medicine, *Vmyl chloride, *Toluene, *xylenes, Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres , Fumes, Organic solvents. Exposure, Chloroform, Naphthas, Textile ind ustry Identifiers: ^Occupational Safety and Health Act of 1970, *Toxic hazards, NTISHEWOSH PB-249 432/6ST NTIS Prices: PC$3.50/MFS2.25 R&S o o(7) 32 o Health Hazard Evaluation/Toxicity Determination Report H.H.E. 74-24,92/95-246, Uncle Bill's Pick-N-Pay Market, No. 10, Miadleburg Heights, Ohio, Madsen's Valu Center, Mankato, Minnesota, and Kroger Company, Logan, West Virginia National Inst, for Occupational Safety and Health, Cincinnati, Ohio. (390 765) Final rept. Vandervort, Robert, Brooks, Stuart M. C6104J4 Fid: 06J, 06T, 57U, 94D, 68G GRAI7608 De'c 7 5 31 p Rept No: NIOSH-TR-HHE-74-24-246, NIOSH-TR-HHE-74-92-246 Monitor: 18 Also available as report no. NIOSH-TR-HHE-74-95-246. See 925. also P3-249 Abstract: At the request of employees from several supermarkets, NIOSH conducted health hazard surveys to evaluate exposures to substances emitted by hot-wire cutting of polyvinyl chloride meat-wrapping films and thermal activation of meat package price labels. Meat department employees were interviewed and given physical examinations and pulmonary function tests. Blood samples were also obtained. Environmental air sampling was also conducted. Based upon these medical and environmental data and upon other information regarding meat wrapping and labeling operations, it was determined that hot wire cutting of pVC meat wrapping films and thermal activation of price labels can release irritant substances into the work environment. Mo health hazard exists from vinyl chloride monomer however. Descriptors: *Hazardous materials, *Industrial medicine, *7inyl chloride, *Hydrogen chloride, ^Polyvinyl chloride. Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene, Industrial atmospheres. Exposure, Composite wrapping Identifiers: ^Occupational Safety and Health Act of 1970, *Toxic hazards, Air sampling, Phthalic anhydrides, NTISHEWOSH PB-249 426/8ST NTIS Prices: ?C$4.00/MF$2.25 R&S 006103 33  a o R&S 006104 Health Hazard Evaluation/Toxicity Determination Report H.H.E.' 73-173-244, Borden Chemical Company, Leorainister, Massachusetts National Inst. for Occupational Safety and Health, Cincinnati, Ohio. (390 766) Final rept. Polakoff, Phillip Lee C6104J2 Fid: 06J, 06T, 57U, 94D, Dec 75 14p Rept No: NIOSH-TR-HHE-73-173-244 Monitor: 18 68G GRAI7608 Abstract: NIOSH investigat ed an alleged health haza rd f rom trypsin. a proteolytic enzyme, and Nekal B-78, a surfact ant, in a pla nt manufacturing polyvinyl c hloride resins. Employees war e ad minister ed non-directea medical guesti cnnaires, skin tests and pulm or.ar y functi or. tests. It was determined that a number of emplo y 90S had develop ed allergic sensitization to trypsin, resulting X n r aspirate ry impairment. Some employee s who have not been sen siti zed have sti 11 developed mild upper res piratory tract irritati It was al so determined that several employees who handled th e su r fac rant n=.< al 3-78 had periodically ex perisnced upper airway ir rita tion , gaggin 9 and shortness of breath, This problem was judged t o be the result of poor work practices and no serious health cons eque nces from th 1 s exposure were observed or a nticipated. Descriptors: ^Hazardous materials, *Industrial medicine, *Polyvir.yl chloride, *Trypsin, *Surfactants, Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres , Exposure, Respiratory system, Chemical industry. Allergic diseases Identifiers: *Occupational Safety and Health Act o 197 G, Toxic hazards, NTISHEWOSH PB-249 4 2 4/3 S T NTIS Prices: PCS3.50/MFS2.25 34 Health Hazard Evaluation/Toxicity Determination Report H.H.2. 75-90-236, Russell Corporation Alexander City, Alabama National Inst. for Occupational Safety and Health, Cincinnati, Ohio. (390 766) Final rept. Geissert, Jack 0. C6104H2 Fid: 0 6J, 06T, 57U, 94D, Nov 75 12p Rapt No: MI0SH-TR-HHE-75-90-236 Monitor: 18 See also PB-249 415. 68G GRAI7608 Abstract: Air sampling for vinyl chloride and medical interviews were conducted by NIOSH to determine if a health hazard existed from the use of polyvinyl chloride-based inks in the screen-printing of garments. The potential health hazard of mineral spirits used m cleaning the screens was also evaluated based upon environmental data and information collected during confidential employee interviews. No health hazard was found to exist from vinyl chloride, however, mineral spirits was found to cause skin problems following worker contact. Descriptors: ^Hazardous materials, ^Industrial medicine, *7ir.yl chloride, *Polyvinyl chloride, *Inks, ^Printing inks, Toxicity, Criteriai Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres. Textile industry. Interviews, Solvents, Skin diseases Identifiers: ^Occupational Safety and Health Act of 1970, *Toxic hazards. Air sampling, *Mineral spirits, NTISH2WOSH PB-249 416/9ST NTIS Prices: PCS3.50/MFS2.25 R&S 006105 35 Health Hazard Evaluation/Toxicity Determination 74-61-232, Gates Rubber Company, Denver, Colorado Report National Inst. for Occupational Safety and Health, Cincinnati, r'.:o. (390 766) Final rept, Jun 74-May 7 5 Gunter, Bobby J., Lucas, James B. C6104G2 Fid: 06J, 06T, 57U, 94D, Nov 75 16p Rept No: NIOSH"TR-HHE-74-61-232 Monitor: 18 See also PB-249 413. 68G GRAI7608 Abstract: A plant manufacturing extruded hose, principally from -e extrusion of polyvinyl chloride, was investigated by NIOSH to evaiiate. employee exposures to cyclohexanone, TDI, trichloroethylene, Es-.'-. e thermoplastic polyurethane, methylene chloride, Nigrosine, Di-2-v::. 1 hexyl phthalate (DOP oil), dust, and vinyl chloride. It was deter*. j. that a potential health hazard may exist from exposure :r cyclohexanone, and that several cases of primary irritant derir.::'.! had occurred following repeated exposure to solvents. Alt hong:, or. . / one of 38 vinyl chloride samples was found to exceed the Feirrti Standard action level, it was recommended that airborne concentrair:r be reduced to levels not detected by the recommended analyr.:r techniques. Descriptors: ^Hazardous materials, *Indusrrial medicine, chloride resins, *Cyclohexanones, *Solvents, organic sol Polyvinyl chloride. Isocyanates, Polyurethane resins, Pla *.rc .. Toxicity, Criteria, Inspection, Standards, Recommendations, Iadu.".f -1 hygiene. Industrial atmospheres, Chloromethanes, Hoses, Manuf acru;i.. . Dermatitis, Carcinogens Identifiers: *Occupational Safety and Health Act of 197U, *r: ::: hazards. Air sampling, NTISHSWOSH PB-249 4 1 2/8ST NTIS Prices: PCS3.50/MFS2.25 R&S 006106 36 Health Hazard Evaluation/Toxicity Determination Report H.H.E. 75-120-22C, Storm Products Company, Palo Alto, California National Inst. for occupational Safety and Health, Cincinnati, Ohio. (390 766) Final rept. okawa, Melvin T. C6104D2 Fid: 06J, 06T, 57U, 94D, Sep 75 5p Sept No: NIOSH-TR-HHE-75-120-220 Monitor: 18 See also PB-249 401. 68G GRAI7608 Abstract: NIOSH conducted a health hazard survey at a plant producing finished cables. A small extruder is used to coat wire with PVC plastic or other coating materials. Environmental air samples were collected for vinyl chloride analysis and no detectable amounts war found on any of the samples. It was concluded that a potential healt hazard from vinyl chloride gas does not exist under conditions found during this evaluation. Descriptors: *Hazardous materials, ^Industrial medicine, ^Polyvinyl chloride, *Vinyl chloride resins, Plastic coatings, Gases, Carcinogens , Toxicity, Criteria, inspection, Standards, Recommendations, Industrial hygiene, Industrial atmospheres Identifiers: ^Occupational Safety and Health Act of 1970, *Toxic hazards. Air sampling, NTISHEWOSH PB-249 4C0/3ST NTIS Prices: PC$3.50/MFS2.25 R&S 006108 Health Hazard Evaluation/Toxicity Determination Report H.H.E. 75-94-219, Proto Production Plastics, Inc., Boulder, Colorado National Inst. for Occupational Safety and Health, Cincinnati, Ohio. (390 766) Final rept. Ruhe, Raymond L. C6104D1 Fid: 06J, 06T, 57U, 94D, Sep 75 6p Rept No: NIOSH-TR-HHE-75-94-219 Monitor: 18 See also PB-249 400. 68G GRAI7608 Abstract: A plant manufacturing polyvinyl chloride telephone switchbox covers by naans of an injection molding process was investigated by NIOSH to eva luate exposure of employees to vinyl chloride. Air samples were obtaine d for vinyl chloride analysis and there were no detectable amounts of vinyl chloride found. Non-directed medical questionnaires were also administered and on the basis of medical and environmental data, it was determined that a health hazard did not exist at the time of this eval uation. Descriptors: *Hazardous materials, ^Industrial medicine, *Polyvinyl chloride, Vinyl chloride resins. Plastics industry. Carcinogens, Gases , Exposure, Toxicity, Criteria, Inspection, Standards, Recommendations , Industrial hygiene. Industrial atmospheres Identifiers: Occupational Safety and Health Act of 1970, *Toxic hazards. Air sampling, NTISHEWOSH PB-249 3 99/7ST NTIS Prices: PC$3.50/MFS2.25 38 Health Hazard Evaluation/Toxicity Determination Heport H.H.S. 74-118-218, General Tire and Rubber Company, Marion, Indiana National Inst, for Occupational Safety and Health, Cincinnati, Ohio. (390 766) Final rept. Dec 74-Jan 75 Roper, C. Paul, Cornier, John W. Jr C6104C4 Fid: 06J, 06T, 57D, 94D, Aug 75 20p Rept NO: NIOSH-TR-HHE-74-118-218 Monitor: 18 See also PB-249 399. 68G GRAI7608 Abstract: A plant which manufactured molded urethane cushions for automobile seats and bulk urethane foam for a variety of commercial purposes was investigated by NIOSH to evaluate employee exposure to toluene 2,4-diisocyanate, polyvinly chloride resins, and mold release wax. Environmental measurements were performed, medical interviews and pulmonary function tests were administered, and work practices were observed. It was determined that airborne concentrations of toluene 2,4-diisocyanate are potentially toxic to employees at the foam line in the Slab Department but not in the Molded Foam Department. Particles of mold release wax were found to cause temporary irritant symptoms in some workers. Exposure to polyvinyl chloride resins was not believed to pose any health hazard under conditions observed during this evaluation. Descriptors: *Hazardous materials, *lndustrial medicine, *?oly7ir.yl chloride, *Mold release agents. Plastics industry. Isocyanates, Urethanes, Waxes, Exposure, Molding materials, Gases, Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres. Carcinogens, Vinyl chloride resins Identifiers: *Occupational Safety and Health Act of 1970, *Toxic hazards, *Isocyanic acid/(methylphenylene-ester) di, Air sampling, NTISHEWOSH PB-249 3 9 8/9 ST NTIS Prices: PCS3.50/MFS2.25 R&S 006109 39 R&S 006110 Health Hazard Evaluation/Toxicity Determination Report H.H.E. 74-59-217, Goodyear Tire and Rubber Company, St. Marys, Ohio National Inst. for Occupational Safety and Health, Cincinnati, Ohio. (390 766) Final rapt. Jul 74-Mar 75 Vandsrvort, Robert C6104C3 Fid: 06J, 06T, 57U, 94D, Aug 75 6p Rept No: NIOSH-TR-HHE-74-59-217 Monitor: 18 See also P3-249 398. 68G GRAI76C8 -- Abstract: NIOSH evaluated employee exposures to vinyl chloride moncra ar in the mixing and film casting processes during th e manufacture of clear plastic films by the solvent casting method, Air samples we r a obtained and no detectable levels of vinyl chloride we re found. It v as determined that a health hazard did not exist at the time of th is evaluation. Descriptors: *Hazardous materials, *Iadustrial medicina, Vinyl chloride, *Polyvinyl chloride. Plastics industry. Carcinogens, Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres Identifiers: *Occupational Safety and Health Act of 1970, Toxic hazards. Air sampling, NTISHEWOSH PB-249 397/1 ST NTIS Prices: PC$3.50/MFS2.25 40, Health Hazard Evaluation/Toxicity Determination 74-125-215, Monaghan Company, Denver, Colorado Report H.H.z. National Inst. for Occupational Safety and Health, Cincinnati, Ohio. (390 766) Final rept. Dec 74-May 75 Gunter, Bobby J., Butler, G eorge , Lucas, C6104C1 Fid: 06J, 06T, 57U, 9 4D, 68G Jul 75 8p Rept No: NIOS H-TR-HHE--74 -- 125-215 Monitor: 18 See also PB-249 396. James B. GRAI7608 Abstract: A health hazar d sur vey was conducted by NIO SH to evaluate worker exposure to vinyl chi orid e in a plant utili zing powdered, pelletized, and film, PVC . Ba sed on the results of environment al measurements, employee in tervi ews. limited physical examinations, observation of work pract ices. and a review of literat ure pertaining to the toxicity of viny 1 chi orid e, it was determined that a health hazard did not exist at the time of this investigation. Descriptors: ^Hazardous materials, ""Industrial medicine, *Vinyl chloride resins, *polyvinyl chloride. Plastics industry. Carcinogens, Gases, Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres Identifiers: ""Occupational Safety and Health Act of 1 970, `Toxic hazards. Air sampling, NTISHEWOSH PB-249 3 95/5ST NTIS Prices: PC$3.50/MFS2.25 Health Hazard Evaluation/Toxicity Determination Repor 75-20-209, Richdel Corporation> Carson City, Nevada H. H National Inst (390 766) for Occupational Safety and Health, Cincinnati, Ohio. Final re Dt. Mar -A pr 7 5 Okawa, M elvi n T C61 04A3 F Id: 0 6 J, 06T, 5 7U, 94D, Jul 75 8p Rept No: NIO SH- TR-HHE -75- 20 -209 Monitor: 18 Sea also PB- 249 3 90. 68G GRAI76Q8 Abstract : A regrind ing o peration in a plant manufacturing mold cd plastic val ves was stu di ed by NIOSH. 3ased upon environmental a ir sampling me asurement s. an alysis of wor k practices, and on availab le informat ion regarding t he toxicity of vinyl chloride, it w as determin ed t hat a potential health hazard does exist. Descriptors: *Hazardous materials, ^Industrial medicine, *Vinyl chloride, Carcinogens, Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres, Plastics, Valves, Moldings Identifiers: *Occupational Safety and Health Act of 1970, *Toxic hazards. Air sampling, NTI5HEW0SH PB-249 38 9/8S NTI5 Prices: PC$3.50/MFS2.25 Health Hazard Evaluation/Toxicity Determination Report H.H.E. 75-1-194 National Inst. for Occupational Safety and Health, Cincinnati, Ohio. (390 766) Final rept. Okawa, Melvin T. C6103IU Fid: Q6J, 06T, 57U, 94D, May 75 6p Rept No: NIOSH-TR-HHS-75-1- 194 Monitor: 18 See also PB-249 375. 68G GRAI7608 Abstract; An extrusion operation for wire cable was studied by NIDSH to evaluate employee exposure to vinyl chloride. It was determined that vinyl chloride gas may be potentially toxic at the concentrations measured during the NIOSH evaluation. This determination was based on exposure times, work practices, and the carcinogenic potential of vinyl chloride. Descriptors: *Hazardous materials, ^Industrial medicine/ *Vinyl chloride, ^Carcinogens, *Cables (Ropes), Toxicity, Criteria, Inspection , Standards, Recommendations, Industrial hygiene. Industrial atmospheres. Plastics, tfire. Extrusions, Exposure Identifiers: ^Occupational Safety and Health Act of 1970, *Toxic hazards, NTISHEWOSH PB-249 374/DST NTIS Prices: PCS3.50/MF$2.25 JJ W o o --CJD. CO 4'} Health Hazard Evaluation/Toxicity Determination 74-134-193, PHC Industries, Inc., Camden, New Jersey -Report H.H.E. National Inst. for Occupational Safety and Health, Cincinnati, Ohio. (390 766) Final rept. Gilles, Dawn C6103I3 Fid: 06J, 06T, 57U, 94D, May 75 6p Hept No: NIOSH-TR-HHE-74-13 4-193 Monitor: 18 See also P3-249 374. 68G G R A17 6 0 8 Abstract: NIOSH conducted a health hazard evaluation at a plant which manufactured handles from PVC resins. On the basis cf environmental sampling conducted at the molding and extrusion processes, it was determined that a health hazard from exposure tc vinyl chloride monomer did not exist at the time of this evaluation. Descriptors: Hazardous materials, Industrial medicine, Vinyl chloride, Polyvinyl chloride, Carcinogens, Toxicity, Criteria, Inspection, Standards, Racommendations. Industrial hygiene. Industrial atmospheres. Extrusion, Exposure, Moldings, Polymers identifiers: Occupational Safety and Health Act of 1970, Toxic hazards. Air sampling, NTISHEWOSH PB-249 373/2ST NTIS Prices: PC$3.50/MF32.25 aj Co w O 0C5D & 44 VC-PVC Crisis: A Systematic Approach to Toxicological Problems California Univ., Berkeley Kland, M. J. A7265F3 Fid: C6T, 57Y Aug 75 34p Rept No: CONF-750673-3 Contract: W-7405-ENG-48 Monitor: 18 Lawrence EHA01C4 Berkeley Lab. (1112800) Abstract: For abstract, see ERA 01 04, number 05829. Descriptors: (*PVC, *Health hazards), (*Vinyl monomers. Health hazards ), (^Carcinogens, Health hazards), (^Organic chlorine compounds. Health hazards). Biological effects, Carcinomas, Human populations. Neoplasms, Reviews, Toxicity Identifiers: ERDA/560306, NTISERDA LBL-3275 NTIS Prices: PCS 4.00/MFS2.25 ro - A2 rr.*nact availjli: R&S 006115 45 Epidemiology Studies. Task III. Vinyl Chloride American Public Health Association, Washington, D.C.^Environmental Protection Agency, Washington, D.C. Office of Toxic Substances. Final rept. AUTHOR: Landau, Emanuel, Brinkman, Charles P., C5875H1 FLD: 06J, 57U*, 68G* USGRDR7 605 Nov 75 106p* CONTRACT: EPA-68-01-2490 MONITOR: EPA/560/6-75/002 Kanos, Nicholas E. ABSTRACT: Using data from the 1970 Census of Population estimates of the number of people living within a 5 mile radius of industrial plants producing vinyl chloride and vinyl chloride resins was prepared. Findings are reported. The sex, and age characteristics are pro vided. DESCRIPTORS: ^Epidemiology, *Vinyl chloride, *Industrial medicine, Public health. Vinyl chloride resins. Industrial plants. Exposure, Populations, Demography, Tables (Data), Environments IDENTIFIERS: NTISEPAOTS PB-248 426/9ST NTIS Prices: PC35.50/MFS2.25 R&S 006116 46 Health Hazard Evaluation/Toxicity Determination Report 74-151-181, Western Forge Corporation, Colorado Springs, Colorado National Inst., for Occupational Safety and Health, Cincinnati, Ohio. (390 766) Final rept. AUTHOR: Butler, George J. C5793I1 FLD: 06J, 06T, 57U, 94D, Apr 75 7p REPT NO: NIOSH-TR-HHE-74-151-181 MONITOR: 18 68G USGRDB7604 ABSTRACT: NIOSH conducted an environmental survey of a forge manufacturing hand tools. Employees were exposed to vinyl chloride gas in the assembly and packing area arising from the vinyl chloride coating applied to packing containers. It was determined that employees were exposed to potentially toxic levels of vinyl chloride at the time of this evaluation. Recommendations vere made regarding reduction of airborne concentrations and the use of respiratory protective equipment. DESCRIPTORS: *Hazardous materials, *Industrial medicine, *Vinyl chloride, ^Polyvinyl chloride. Toxicity, criteria. Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres , Protectors, Exposure, Forging, Thresholds(Perception), Toxic tolerances. Films, Packaging materials. Respirators IDENTIFIERS: *Occupational Safety and Health Act of 1970, *Toxic hazards, Metalworking industry, Maximum permissible exposure. Air sampling, NTISHEWOSH PB-246 497/2ST NTIS Prices: PC$3.50/HFS2.25 Health Hazard Evaluation/Toxicity Determination Report 74-149-180,Protecto Wrap Company, Denver, Colorado National Inst, for Occupational Safety and Health, Cincinnati, Ohio. (390 766) Final rept. AUTHOR: Butler, George J. C5793H4 FLD; C6J, 06T, 57U, 94D, Apr 75 7p REPT NO: NI0SH-TR--HHE-74-14 9-180 MONITOR: 18 68G USGBDR7604 ABSTRACT: The environmental survey of a plant manufacturing a polyvinyl chloride backed material by NIOSH investigators revealed potentially hazardous levels of vinyl chloride gas. It was recommended that airborne concentrations of vinyl chloride be reduced to non-detectable levels and that respirators be worn by exposed employees until control measures are effective. DESCRIPTORS: *Hazardous materials, *Industrial medicine, *?inyl chloride, *Polyvinyl chloride. Toxicity, Criteria, inspection. Standards, Recommendations, Industrial hygiene. Industrial atmospheres , Exposure, Evaluation, Plastics industry. Respirators, Gases, Surveys IDENTIFIERS: *0ccupational Safety and Health Act of 1970, *Toxic hazards. Air sampling, NTISHEWOSH PB-246 4 96/4ST NTIS Prices: PCS3.50/MFS2.25 R&S 006118 48 R&S 006119 Health Hazard Evaluation/Toxicity Determination Report 74-96-173 Richdel Corporation# Carson City, Nevada National Inst, for Occupational Safety and Health, Cincinnati, Ohio. (390 766) Final rept. AUTHOR: Okawa, Melvin T. C5793H2 FLD: 06J, 06T, 570, 94D, Feb 75 8p REPT NO: NIOSH-TR-HHE-74-96-173 MONITOR: 18 68G 0SGRDR76O4 ABSTRACT: . A plant involved in injection molding of polyvinyl chloride was studied by NIOSH to evaluate employee exposures to vinyl chloride and trichloroethylene, which is used as a degreaser. It was determined that a potential health hazard from exposure to vinyl chloride did exist in the Regrind Room, and a potential hazard may also exist in the injection molding areas. Trichloroethylene was judged to be not toxic at the concentrations measured at the degreasing operation. DESCRIPTORS: ^Injection molding, ^Hazardous materials, ^Industrial medicine, *Vinyl chloride, *Polyvinyl'chloride, *chlorohydrocarbons, Degreasing, Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres. Respirators, Exposure, Protectors, Plastics industry. Evaluation, Toxic tolerances. Thresholds(Perception), Surveys, Gases IDENTIFIERS: Occupational Safety and Health hazards, Ethylene/trichloro, Air sampling, exposure, 'NTISHEWOSH Act of 1970, *Toxic Maximum permissible PB-246 494/9ST NTIS Prices: PC$3.50/MFS2.25 49 ucav.ii nwm &vaiuation/Toxicity Determination Report 74-89-189, -New York Telephone and Telegraph Company, New York, N.Y National Inst. for Occupational Safety and Health, Cincinnati, Ohio. (390 766) Final rept. AUTHOR: Straub, Wesley E. C5793H1 FLD: 06J, 06T, 570, 94D, Apr 75 7p EEPT NO: NIOSH-TR-HHE-74-89-1 89 MONITOR: 18 68G USGRDE7604 R&S OOfiion ABSTRACT: NIOSH conducted an environmental survey to determine employee exposure to vinyl chloride, styrene, benzene, and hydrogen chloride during the .application of heat shrinkable tape to telephone cables. It was determined that air concentration levels were below detectable levels for all substances tested and therefore were judged to be not toxic under the conditions noted during this evaluation. DESCRIPTORS: ^Hazardous materials, Industrial medicine, *Styrene, Benzene, ^Hydrogen chloride, Vinyl chloride. Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres. Evaluation, Exposure, Coatings, Polyvinyl chloride. Thresholds(Perception), Toxic tolerances IDENTIFIERS: Occupational Safety and Health Act of 1970, *Toxic hazards. Air sampling, Maximum permissible exposure, NTISHEWOSH PB-246 493/1 ST NTIS Prices: PC$3.50/MF$2.25 Health Hazard Evaluation/Toxicity Determination Report 74-85-185, M. H. Gall Company, Lancaster, Pennsylvania National Inst. for Occupational Safety and Health, Cincinnati, Ohio. (390 766) Final rept, AUTHOR: Straub, Jfesley E. C5793G4 FLD: 06J, 06T, 57U, 94D, Apr 75 IQp REPT NO: NIOSH-TS-HHE-74-85-185 MONITOR: 18 68G USGRDR7604 ABSTRACT: A health hazard survey was conducted by NIOSH to investigate a potential health hazard at a company performing lamination of printed material on a job basis. The laminate is a polyvinyl chloride based product which is layered `with the printed material, then the layers are heated for curing. It was determined that a potential health hazard exists at the lamination press from vinyl chloride gas, based on environmental measurements, observation of work practices and a review of past medical reports. DESCRIPTORS: ""Hazardous materials, *Industrial medicine, *Vinyl chloride, *Polyvinyl chloride. Toxicity, criteria. Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres , Exposure, Evaluation, Gases, Laminates, Carcinogens, Liver, Thresholds(Perception), Toxic tolerances. Ventilation, Surveys IDENTIFIERS: *Occupational Safety and Health hazards. Lamination, Air sampling. Cancer, exposure, NTISHEWOSH Act of 1970, *Toxic Maximum permissible PB-246 492/3ST NTIS Prices: PC$3.50/MF$2.25 &S 006121 Health Hazard Evaluation/Toxicity Determination Report 74-71-142, Delco Reray Division, Anaheim, California National Inst, for Occupational Safety and Health, Cincinnati, Ohio. (390 766) Final rept. AUTHOR: Okawa, Melvin T. C5793G1 FLD: 06J, 06T, 57U, 94D, Sep 74 5p REPT NO: NIOSH-TR-HHE-74-71-142 MONITOR: 18 68G USGHDR7604 -- ABSTRACT: An operation in which polyvinyl chloride was being used to manufacture the separators used in automobile batteries was studied by NIOSH investigators. It was determined that vinyl chloride vapors were not toxic at the concentrations measured during normal operating conditions. This determination was based upon the environmental levels of chloride, the conditions of use of polyvinyl chloride, and current information available on the toxicity of vinyl chloride. DESCRIPTORS: ^Hazardous materials, *Industrial medicine, Vinyl chloride, Battery separators. Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres , Vapors, Exposure, Evaluation, Electric batteries IDENTIFIERS: Occupational Safety and Health Act ,of 1970, *Toxic hazards. Battery industry. Air sampling, NTISHEWOSH PB-246 489/9ST NTIS Prices: PCS3.50/MF$2.25 R&S 006122 52 Health Hazard Evaluation/Toxicity Determination Report 74-29-161, Ethyl Visqueen Division of Ethyl Corp., Terre Haute, Indiana National Inst. for Occupational Safety and Health, Cincinnati, Ohio. (390 766) Final rept. AUTHOR: sutler, George J., Bodner, Arnold H. C5793Z2 FLD: 06J, 06T, 570, 94D, 68G USGRDF.7604 Nov 74 10p REPT NO: NIOSH-TR-HHE-74-29-161 HONITOR: 18 ABSTRACT: A manufacturer of polyvinyl chloride pip e was invest igated by NIOSH to evaluate worker exposures t o polyvinyl chloride. Cr ystals of polyvinyl chloride resin are mixed with other materials an d then, extruded into pipe. Air samples were collected, workers were given medical interviews, and blood samples were taken to be analyz ed for serum glutamic-oxaloacetic transaminas e. It was determined that a health hazard from vinyl chloride monoae r did not ex ist at the t ime of the survey but that a potential carcin ogenic hazar d did exist in t he blending room areas of the plant. DESCRIPTORS: ^Hazardous materials, *industrial medicine, *Polyviayl chloride, *Vinyl chloride. Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres. Evaluation, Surveys, Interviews, Blood analysis. Pipes (Tubes) , Carcinogens, Plastics industry. Dust, Statistical data. Chemical ind ustry IDENTIFIERS: Occupational Safety and Health Act of 1970, *Toxic hazards. Air sampling, NTISHEWOSH PB-246 482/4ST NTIS Prices: PC$3.50/HF$2.25 R&S 006123 53 R&S 006124 Toxicology of Plastic Devices Having Contact with Blood Children's Hospital Medical Center, Boston, Mass.* National Heart and Lung Inst., Bethesda, Md. (082 790) Comprehensive rept. Sep 72-Sep 75 AUTHOR: Kevy, Sherwin V., Button, Lawrence N., C5751F1 FLD: 06T, 131, 06L, 57Y*, 710, 95C Oct 75 112p* CONTRACT: PHS-72-2968 MONITOR: NIH/NHLI-72-2969-CR See also PB-244 753. Jacobson, May USGRDR760 3 S. ABSTRACT: The objectives of this research were twofold: (1) the utilization of an animal model to evaluate the functional effect of Di-2-ethylhexylphthalate (DEHP) accumulation, and (2) the development of an in vitro testing procedure that could be correlated with the animal studies. The rate of extraction of DEHP from polyvinyl chloride (PVC) is dependent upon both the temperature during storage and the lipid content of the medium. DEHP so obtained is in true solution, with particle sizes less than 0.22 micron. Tissue culture studies demonstrate that solubilized DEHP in varying concentrations inhibits the growth and ultimately kills human diploid fibroblasts. PVC and siliconized glass transfused rhesus had abnormalities in liver histopathology and liver functions for up to 14 months following cessation of transfusions. DEHP or silicon persisted in the tissues for up to 14 months post-transfusion. Both the control rhesus and those transfused with platelets processed in polyethylene containers were normal. DESCRIPTORS: ^Plastics, ^Toxicology, ^Polyvinyl chloride. Blood, In vitro analysis. In vivo analysis. Tissue culture, Body fluids. Blood plasma. Blood serum. Blood cells. Plasticizers, Polymers, Blood transfusion, Liver, Spleen, Tissues(Biology) , Histology, Pathology, Monkeys, Experimental data. Accumulation IDENTIFIERS: *Biomaterials, *Blood compatible materials. Animal models , *Phthalic acid/bis (ethylhexyl-ester) , Histopathology, Bioaccumulati on, NTIS NIHHLI PB-247 168/8ST NTIS Prices: PC$5.50/MFS2.25 54 Recommended Standard for Occupational Exposure to Vinyl Chloride National Inst, 407 192) C5674J3 FLD: 197 5 10 p MONITOR: 13 See also P3-246 for Occupational Safety 06J, 06T, 570, 940, 68G 692. and Health, Rockville, USGRDR7602 Hd. ABSTRACT: The eport includes: Background (events and toxicological finds) of the t.andard; scope and application; definitions of terms; requirements for regulated areas; routine operations; reactor and vessel entry; maintenance and. decontamination; hygiene measures; signs; information and training; environmental monitoring and record keeping; reports; medical surveillance. Despite the fact that animal experiments have shown no liver tumors at atmospheric concentrations of 50 ppm, the concept of an allowable working level is rejected. Since there is measurable concentrations of vinyl chloride personnel should wear an air-supplied respirator because chemical cartridge respirators do not afford adequate protection against vinyl chloride vapors. DESCRIPTORS: ^Hazardous materials, industrial medicine, *Vinyl chloride. Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres, Chlorohydrocarbons, Chlorine alaphatic compounds, protection. Safety, Requirements, Evaluation, Carcinogens IDENTIFIERS: *0ccupational Safety and Health Act of 1970, *Toxic hazards. Air sampling, NTISHEWOSH PB-246 6 91 /Q ST NTIS Prices: PCS3.50/MFS2. 25 33 CO o o CO N> CO 55 Registry of Toxic Effects of Chemical Substances. 1975 Edition National Inst, for Occupational Safety and Health, Rockville, AUTHOR: Christensen, H. E., Luginbyhl, T. T., Carroll, B C5673A3 FLD: 06T, 06J, 57Y*, 570, 68G* 'JSGRDR76 0 2 Jun 75 1399p* , REPT NO: NIOSH-TSL-75 CONTRACT: PH5-CDC-99-74-92 MONITOR: 18 Md. ABSTRACT: The 1975 Edition of the Registry of Toxic Effects of Chemical Substances, formerly known as the NIOS H Toxic Substances List, is the fifth Edition prepared in com pliance with the requirements of the Occupational safety and He alth Act of 1970 (PL-91-596). This Registry contains, toxicity information on approximately 17,000 unique chemical substances along with about 48,000 synonyms. Information is given cn route of entry, toxic dose and toxic effects including an indication of existi ng evidence of the substance may be carcinogen, mutagen, teratogen, etc DESCRIPTORS: *Toxicity, ^Chemical compounds, ^Hazardous materials. Indexes(Documentation), Public health. Dosage, Industrial' medicine. Standards, Chemical properties. Exposure, Asbestos, Pesticides, Carcinogens, Vinyl chloride. Mutagens, Aquatic animals. Toxicology IDENTIFIERS permissible NTISHEWOSH Occupational Safety and Health Act of 1970, Maximum exposure. Teratogens, Occupational safety and health. I PB-246 557/3ST NTIS Prices: PC$41.75/MFS2.25 R&S 006126 56 The Physiological and Toxicological Aspects of Smoke Produced During the Combustion of Polymeric Materials Utah Oniv., Salt Lake City. Flammabi.lity Sesearch Center. National Science Foundation, Washington, D.C. Research Applied to National Needs, Annual rept. 1972-73 AUTHOR: Einhorn, I. N., Birky, M. M., Grunnet, M. L., packham, S. C., Petajan, J. H. C5384L3 FLD: 06T, 06P, 57Y, 57S, 71 USGRDR7524 24 Sep 73 160p REPT NO: FRC/UU-12, UTEC-73-161 GRANT: NSF-GI-33650 MONITOR: NSF/RA/E-73-196 ABSTRACT: A study was undertaken at the Flammability Research Center of the University of Utah to determine the physiological and toxicological effects of smoke. Four classes of materials were selected for study: cellulosics, urethanes, polyvinyl chlorides, and Douglas fir. Smoke chambers and animal exposure chambers were developed for the analysis of smoke and its components and the observation of effects of combustion products on animals. The effects of combustion products on survival response in rats were measured, and toxicological studies of rats under exposure to smoke were made. The effects of combustion on the eyes of the animals are the subject of continuing experimentation. Small-scale laboratory fire experiments are being correlated with full-scale fire tests conducted at the National Bureau of Standards, Selected case histories of fire injuries are being studied to determine the medical history of victims until recovery. DESCRIPTORS: Toxicology, Combustion products, Flammability, Materials, Smoke, Fumes, Physiological effects. Responses, Experimental data. Laboratory animals, Rats, Polyvinyl chloride. Chemical analysis. Urethanes, Injuries, Cellulose, Fir wood IDENTIFIERS: NTISNS FRA PB-244 876/9ST NTIS Prices: PCS6.25/HF$2.25 R&s 006127 57 R&S 006128 Toxicology of Plastic Devices Having Contact with Blood tah Univ., Salt Lake City. Dept. of Applied Pharmaceutical Sciences.^National Heart and Lung Inst./ Bethesda, ft d. Annual rept. 1 May 74-30 Apr 75 AUTHOR: Petersen, Robert V,, Lyman, Donald J., Roll, Swinyard, Ewart A. C5332D3 FLD: 06T, 06L, 57Y*, 95A*, 95C USGRDR75 23 1 May 75 116p CONTRACT: PHS-73-2908 MONITOR: NIH/NHLI-7 2-6 See also PB-233 701. David B., ABSTRACT: The project is concerned with toxicological evaluation of polyvinyl chloride (PVC) and, more specifically, the commonly used plasticizer, di-(2-ethylhexyl) phthalate (DEHP) . Selected findings indicate that (1) the acute and subacute LD50 of a metabolite of DEHP (mono-(2-ethylhexyl) phthalate) given intravenously or intraperitoneally in mice or rats is highly toxic and irritant. (2) Analysis of particle size distribution of DEHP dispersed in fetal calf serum by sonication indicates that the vast majority of particles are less than 2 microns diameter. (3) DEHP appears to have some effect on chromosomes in human leukocytes and human fetal lung cells in tissue culture. (4) DEHP prolongs hexobarbital sleep. Phthalate-contaminated sheets caused greater adhesion and aggregation of platelets than methanol-cleansed PVC when exposed to sheep blood in ex-vivo experiments. DESCRIPTORS: Polyvinyl Toxicology, Lethal dosage, animals. Tissue culture, supplies. Mechanical organs chloride. Pathology, Bioassay, Plastics, ^Plasticizers, Body fluids. Blood, Laboratory^ Humans, Phthalates, Medica^^ IDENTIFIERS: Blood compatible materials. Biomaterials, Phthalic acid/bis (ethylhexyl-ester) , NTISNIHHLI PB-244 7 53/0 ST NTIS Prices: PC$5.25/MF$2.25 Three Week Intravenous Administration in the Dog DI (2 - Ethylhexyl) Phthalate Hazleton Labs. America, Inc., Vienna, Ya.*National Heart and Lung Inst., Bethesda, Md. Final rept. 9 Jul 74-28 Feb 75 AUTHOR: Rutter, Henry A. Jr C5254F1 FLD: 06T, 57Y USGHDR7522 9 Apr 75 55p CONTRACT: NOt-HB-2-2991 NONITOR: 18 Sponsored in part by National Heart and Lung Inst,, Bethesda, Md. See also PB-224 376. ABSTRACT: A repeated dose of approximately 0.50, 0.75, and 1.4 mg/kg/day of di(2-ethylhexyl) phthalate in canine plasma was administered to beagles for 21 days. No consistent compound-related alterations were observed in animal behavior or hematological and clinical chemical parameters. Terminal body weights, organ weights, and organ/body weight ratios were acceptable, normal limits and comparable to control values. Compound--related histomorphologic alterations were not observed in dogs receiving various concentrations of di (2-ethylhexyl) phthalate leached from PVC blood bags during storage. DESCRIPTORS: *Toxicity, *Phthalates, *Plasticizers, Dogs, Bioassay, Laboratory animals. Dosage, Medical equipment, Medical supplies. Tables (Data) , Experimental data. Animal behavior. Histology, Morphology, Polyvinyl chloride, Pathology IDENTIFIERS: Biomaterials, NTISNIHHLI R&S 006129 PB-244 2 62/2ST NTIS Prices: PC$4.25/MFS2.25 Ambient Air Measurements of Vinyl Chloride in the Niagara Falls Area National Environmental Research Center, Research Triangle Parle, N.c. Chemistry and Physics Lab, Environmental monitoring series AUTHOR: Gay, Bruce W. Jr, Noonan, Richard C. C5175A3 FLD: 13B, 07A, 06F, 68A, 99B, 57U May 75 19p REPT NO: EPA/650/4-75/020 PROJECT: EPA-ROAP-21AKC MONITOR: 18 USGRDR7521 ABSTRACT: A 6-day survey was conducted in the Niagara Falls area to determine the concentrati on of vinyl chloride in the atmosphere, Samples were obtained in a residential area adjacent to the chemical plants where vinyl chlorid e emissions were suspected, in areas around the plants, and in othe r areas of Niagara Falls. The highest concentration of vinyl c hloride measured was 40 ppb for a 5-hour integrated sample observed at a residential area two blocks east of a vinyl chloride polymeriza tion plant. Grab samples taken downwind of chemical plants exhibited a high of 28 ppb. Samples taken from downtown Niagara Falls a nd upwind north of the chemical plants contained no detectable vinyl chloride. The areas surrounding the chemical plants, includin g the adjacent residential areas, are also affected by emissions in to the atmosphere of chlorine and other halogenated compounds as exhibited by the deterioration of metal surfaces, particularly alum inum windows and doors. DESCRIPTORS: *Air pollution, *Vinyl chloride, ^Chemical plants. New York, Angiosarcomas, Chlorine organic compounds, Halohydrocarbon Aluminum, Buildings, Corrosion, Sampling, Public health IDENTIFIERS: Air quality, Niagara Falls (New York), *Air pollution sampling, Air pollution effects (MateriaIs), Air pollution effects(Humans) , NTISEPAORD PB-243 695/4ST NTIS Prices: PC33.25/MFS2.25 R&S 006130 60 A Framework for the Control of Toxic Substances (A Compilation of Speeches) Environmental Protection Substances, AUTHOR: Schweitzer, Glenn C5104A1 FLD: 06T, Q6J, Apr 75 57p RSPT NO: EPA/560/4-75-004 MONITOR: 18 Agency, E. 6 8G, 6 8A , Washington, D.C. 68D, 57 Y, 57U, 99 Office of Toxic USGHDR7520 ABSTRACT: This collection of speeches in large measure reflects the evolution of the interests, policies, and programs of the Office of Toxic Substances from April 1973 to March 1975, The speeches deal with questions that are of broad national concern: the identification of chemical hazards, the need for development of toxicological and other data on chemicals, the pending Toxic Substances Control Act, and need for regulation to control toxic chemicals, DESCRIPTORS: ^Public health, ^Toxicology, Environmental impacts, Industrial medicine. Environmental surveys. Government policies. National government, Legislation, Economic impacts. Inorganic compounds. Organic compounds. Vinyl chloride. Regulations, Decision making, Hazards IDENTIFIERS: Hazardous materials, Toxic Substances Control Act, NTISEPAOTS PB-243 459/5ST NTIS Prices: PC$4,25/MF$2.25 Evaluation of Vinyl Chloride Associated with Heat Sealing PVC Products R&S 006132 Environmental Health Lab Mcclellan AFB Calif (407609) Final rspt. AUTHOR: Smith, Billy Greathouse, Jack E. C4745F3 FLD: 6J, 57U Dec 74 70p REPT NO: EHL-74H-17' PROJECT: HAF-351 MONITOR: 18 S., Burnett, U SGRDR 7 515 Ronald D. , Diamond, Philip ABSTRACT: Potential vinyl chloride (VC) exposures were evaluated during meat packaging and during welding operations using heat to join polyvinyl chloride (PVC) sheets or film. The potential for VC exposure was evaluated by analyzing the PVC materials for entrained or encapsulated vc and by analyzing air samples collected during the meat wrapping and welding operations for VC. The results of all analyses are shown. The potential for exposure to vinyl chloride monomer at the 0.1 ppm level was not found to exist in either of the two operations studied. No vinyl chloride monomer was detected in the PVC materials. DESCRIPTORS: *Industrial hygiene, Exposure(Physiology), Polyvinyl chloride. processing ^Packaging, *welding. Gas analysis. Meat, Food IDENTIFIERS: *Vinyl chloride, indoor air pollution, Gas sampling. Air pollution standards, NTISDODAF AD-A009 997/8ST NTIS Prices: PC$4.25/MFJ2.25 preliminary Assessment of the Environmental Problems Associated with Vinyl Chloride and Polyvinyl Chloride Environmental protection Agency, Washington, D.C. Office of Toxic Substances, Interim rept. C4385E4 FLD: 13B, 68G* Sep 74 106p* REPT NO: EPA/560/4-74-001 HONITOR: 18 Report on the Activities Force. USGRDR7509 and Findings of the Vinyl Chloride Task ABSTRACT: The report summarizes the activities and findings of a task force to assess the character and extent of the problems associated with the production, distribution, use, and disposal of vinyl chloride and polyvinyl chloride. The first Section discusses the nature and magnitude of problems. The second discusses previous and planned activities within the Federal Government of particular significance and the role of industry. The report concludes with some specific recommendations. DESCRIPTORS: +Air pollution, *ffater pollution, *Toxicity, *vinyl chloride, ^Polyvinyl chloride, Surveys, Problem solving. Health, Ecology, Tests, Industrial relations IDENTIFIERS: Air pollution abatement, NTISEPAOTS PB-239 1 10/OST NTIS Prices: PCS5.2 5/MFS 2.25 33 R&S 006134 Experimental Data Serving as a Basis for Separate Permissible Concentrations of Dibutylphthalate National Institutes of Health, Unit. *Sn viro nmental Protection Agency, Translation Services Section. AUTHOR: Spasovski, Mincho C4045C2 FLD: 06J, Q6T USGRDR7504 Jul 73 8p REPT NO: NIH-73-370C MONITOR: SPA-TR-29-74 Trans. of Khigiena, E pidemiologiya i p38-44 1964. Bethesda, ild. Translation Research Triangle Park, N.C. Mikrobiologiya (Bulgaria) v7 ABSTRACT: Based on experiments using animals subjected to single and multiple inhalatory, oral and skincoating dosages, and which are supported by mathematical and analogical methods, the separate permissible standard for concentrations of industrial dibutylphthalate heated above 140C is 0.001 milligrams per liter of atmosphere. The toxicity of dibutylphthalate depends upon the modality of its introduction to the organism. Most toxic are its fumes heated above 140c which penetrate and consume the lungs. The substance is weakly toxic in oral application. It does not possess skin absorptive capability. Dibutylphthalate possesses a highly cumulative effect in inhalation and ingestion. The cumulative coefficient falls just short of one, which explains the hypersensitivity associated with it. DESCRIPTORS: *phthallates, *Toxicology, Plastics, *Industrial medicine. Industrial atmospheres. Polyvinyl chloride, Bulgaria, Translations, Lung, Laboratory animals. Experimental data. Exposure, Permissible dosage. Fumes IDENTIFIERS: Phthallic acid/(dibutyl-ester), Indoor air pollution, NTISEPAIS D, NTISNIH PB-237 886-T/ST NTIS Prices: PC$3.25/MFS2. 25 6 4' The Effect of Dibutyl- and Dioctylphthalates on Rats with Oral 'Feeding during Prolonged Testing. Part I. Application and Toxicological Properties of Dibutyl- and Dioctyl-Phthlates National Institutes of Health, Bethesda, Hd. Translation Unit. *Environmental Protection Agency, Research Triangle Parle, N. C. Translation Services Section. AUTHOR: Piekacz, Hanna C3994I4 FLD: 06T 0SGRDR75O3 1974 lOp REPT NO: NIH-73-374C MONITOR: EPA-TR-28-74 Trans. of Roczniki Panstvowego Zaklada Higieny (Poland) v22 p55-61 1971. ABSTRACT: The use of dibutyl- and dioctyl-phthalates is discussed a propos of legislation in various countries, as well as their toxicological properties. This study serves as an introduction to research on hyperacute and extended toxicity of both phthalates. DESCRIPTORS: phthalates, *Toxicology, Chemicals, Polyvinyl chloride. Manufacturing, Poland, Translations IDENTIFIERS: Phthalic acid/ (dioctyl-ester), Phthalic acid/(dibutyl-ester), NTIS2PAISD, NTISNIH PB-237 885-T/ST NTIS Price: PC$3.2 5/MFS2.25 R&S 006136 Accumulation of DI-2-Ethylhexyl Phthalate (DEHP) in Whole Blood, Platelet Concentrates, and Platelet-Poor Plasma Naval Blood Research Lab Chelsea Mass (387481) AUTHOR : .Contreras , T J , , S heibley, R. H. , Valeri, C. R. C3611I1 FLD: 6L USGRDR7424 4 Sep 73 15p PROJECT: MR041.02 TASK: MR041.02.01 . MONITOR: 18 Revision of report dated 30- Mar 73. See also AD-766 554, Availability: Pub, in Transfusion, v14 nl p34-46 Jan/Feb 74, ABSTRACT: The concentration of the plasticizer, di-2-ethylhexyl phthalate (DEHP), in the plasma was measured after storage of the whole blood in polyvinyl chloride plastic bags at 4C for up to 38 days in either ACD or CPD. The plasma from ACD-stored whole blood contained more DEHP than that from CPD-stored whole blood. The continuous-flow centrifugation washing procedures removed about 98 per cent of the DEHP from ACD.whole blood stored for 33 days at 4C. DEHP was assayed in the platelet-rich plasma, platelet-poor plasma, supernatant of the platelet concentrate, washed platelets, and washed red blood cells prepared from CPD whole blood. Very little DEHP was found in the washed red blood cells and platelets, a small amount was found in the platelet-poor plasma, and a large amount in the supernatant of the platelet concentrate. A greater amount of DEHP accumulated in the platelet concentrates that were stored at 22C than in those stored at 4C. When platelet concentrates from CPD whole blood were stored at 22C for 72 hours, the amount of DEHP was about four times that observed after 4C storage for the same length of time. (Author) DESCRIPTORS: *Blood, *Phthalates, *Plasticizers, *Polyvinyl chloride. Plastics, Bags, Blood plasma. Blood platelets. Accumulation, Blood banks. Storage, Blood transfusion. Toxicity IDENTIFIERS: Phthalic acid/fcis(ethylhexyl-ester) , NTISDODN AD-786 2 53/5 SL NTIS Price: Reprint 66 Toxicology of Plastic Devices Having Contact with Blood Children's Hospital Medical Center, Boston, Mass. Annual rept. Sep 73-18 Jun 74 AUTHOR: Kevy, Shervin V., Button, Lawrence N., Jacobson, C3284H1 FLD: 6T, 6L, 57Y, 95A, 95C USGHDR7419 21 Jun 74 52p* MONITOR: NIH/NHLI-72-2969 May S. ABSTRACT: Continued studies are presented that evaluate the possible toxicological effect of DI-2-ethylhexyl phthalate (DEHP) extracted from poly-vinyl chloride (pvc) plastic by blood and biologic fluids. Specific studies are outlined in four areas: The preparation of an antibody to phthalate in rabbits for use in immuno-fluorescent studies and a radioimmunoassay for detection of phthalate; bi-weekly platelet transfusions after storage for 48 hours at 4 and 22C in PVC, polyethylene and siliconized glass is a natural and clinically oriented method of phthalate administration; evaluation of these animals for hepatic, splenic and pulmonary functions by means of nuclear medicine techniques, liver function tests and compartmental BSP analysis; tissue analysis of tranfused and non-transfused patients for DEHP; and quantitative analysis of liver tissue for DEHP of multi-transfused Rhesus monkeys. DESCRIPTORS: *Plastics, ^Toxicology, *Plastici zees, ^Polyvinyl chloride. Blood, Tissue culture. Medical supplies. Mechanical organs. Experimental data. Antibodies, Phthlates, Bioassay, Humans, Laboratory animals. Blood transfusion IDENTIFIERS: *8lood compatible materials, acid/bis (ethylhexyl-ester) , Biomaterials, NTISHEWHLI *Phthalic PB-233 857/2 NTIS Prices: PC$5.75/MF$1.45 R&S 006138 Toxicology of Plastic Devices' Having Contact with Blood Utah univ., salt Lake city. Coll, of Pharmacy. Interim rept. 24 Aug 72-1 May 74 AUTHOR: Lyman, Donald J. , Roll, David B., C3283I1 FLD: 6T, 6L, 57Y*, 95A*, 95C May 74 206p* GRANT: PHS-7 3-290 8 ' MONITOR: NIH/NHLI-73-2908-B Swinvard, Ewart A. USGRDR7419 ABSTRACT: The project is primarily concerned with toxicological evaluation of polyvinyl chloride and, more specifically, the commonly used plasticizer, di (2-ethylhexyl) phthalate (DEHP). Evaluations are concentrated on long range, subtle toxicity potential, although basic acute and subacute studies are also utilized. Plastic composition studies, acute toxicity studies, tissue culture studies, subacute toxicity studies, metabolite identification, teratogenic studies, neurologic studies, larger animal studies, analyses of human blood exposed to plastics during hospital procedures, and possible statistical analysis of human patients following extensive exposure of blood to plastics are included. Selected findings indicate that: Plastic components which contain DEHP as a plasticizer are toxic to L-929 cells in tissue culture; DEHP appears to prevent implantation of fertilized ova in rats and mice; DEHP affects rate and amplitude of contractions . in isolated rat hearts; DEHP is hydrolyzed in vitro by liver microsomes and mitochondria but not by cytosol. DESCRIPTORS: *Polyvinyl chloride, ^Plastics, *Toxicology, Plasticizers, Blood, Medical supplies. Tissue culture. Mechanical organs. Experimental data, Phthalates, Laboratory animals. Humans, Bioassay, Neurology IDENTIFIERS: *.Blood compatible materials, acid/bis {ethylhexyl-ester) , Biomaterials, NTISHEWHLI *Pathalic PB-233 701/2 NTIS Prices: PC$5.75/MFS1.45 68. Dynamics of Hygenic working Conditions and Occupational Disease Incidence among workers in Suspension Polyvinyl Chloride Production over a Number of Years National Institutes of Health, Bethesda, ad. Translation AUTHOR: Filatova, V. S., Antonyuzhenko, V, A. C3214A2 FID: 6J, 6T USGRDR7 418 Jul 74 7p REPT NO: NIH-74-352C nONITOR: 18 Trans. of Gigiena Truda i Professionalnye Zabolevaniya p32-34 1 971 . Unit. (USSR) v15 n4 ABSTRACT: The occupational disease incidence in workers resulting from vinyl chloride air pollution was studied over a period of 17 years (1953-1969). Although industrial conditions have improved, there still occurs new cases of chronic occupational poisoning. Various clinical manifestations of chronic vinyl chloride poisoning, as a function of environmental air pollution have been established, A series of measures designed to improve air quality in work areas is suggested. DESCRIPTORS: Industrial hygiene, *Occupational diseases, Industrial atmospheres, +Polyvinyl chloride, Air pollution. Toxicity, Toxic diseases, USSR, Translations IDENTIFIERS: Air quality, NTISNIH, NTISHEWIHL PB-233 614-T NTIS Prices: PC$4.00/HFS1.45 DO <2 (/> it R&S 006140 Health Hazard Evaluation/Toxicity Determination. John Worrell Company, Sioux Falls, South Dakota National Inst (390 766) for Occupational Safety and Health, Cincinnati, Final rept. Oct 72-Jan 73 AUTHOR: Polakoff, Phillip L., Vandervort, Robert C3084E2 FLD: 6J, 6T, 570, 94D, 68G USGRDR74 16 Oct 73 15p KEPT NO.: NIOSH-TR-089-74, HHE-71-29-89 MONITOR: 18 ABSTRACT: In response to a request received from a representative of employees, the National Institute for Occupational Safety and Health t (NIOSH) conducted a health hazard survey to evaluate exposure to ! thermal decomposition products of polyvinyl chloride meat packaging film at John Morrell Company, Sioux Falls, South Dakota. Based on medical evidence compiled during a limited study of meat wrapping employees it was determined that air contaminants generated by the ! thermal cutting of polyvinyl chloride packaging films in conjunction I with the wrapping of meat are potentially toxic to some meat wrapping employees. Symptoms range from mild eye, nose and throat irritation to more serious respiratory problems for meat wrappers who have an underlying predisposition to respiratory difficulties. Recommendations have been suggested to management regarding preemployment examinations and work practices. DESCRIPTORS: ^Hazardous materials, *Industrial me dicine, *Polyvinyl chloride, Toxicity, Criteria, Inspection, Standards , Recommendations^ Industrial hygiene. Packaging, Pyrolysis, Respirator y infections IDENTIFIERS: *0ccupational Safety and Health Act of 1970, Packaging materials, *Meat packing industry, '`Toxic hazards. Air pollution effects(Humans), NTISNI0SH PB-232 578/5 NTIS Prices: PC$4.00/HFS1.45 Health Hazard Evaluation/Toxicity Determination. Seattle, Washington National Inst. for Occupational Safety and Health, Cincinnati, Ohio. {390 766) Final rapt. Aug 72-Jan 7 3 AUTHOR: Polakoff, Phillip L., Vandervort, Robert C2705I4 FLD: 6J, 57U, 57t, 94D, 68G USGRDR7411 Sep 73 23p REPT NO: NI0SH-TR-Q70-7 4, HHE-72-53-70 MONITOR: 18 Also includes Sept, nos, HHE-72-S4-71 thru HHE-72-58-75. ABSTRACT: In rsponse to a received from a representative of employees the National Institute for occupational Safety and Health (NIOSH) conducted a health hazard survey to evaluate exposure to thermal decomposition products a polyvinyl chloride (PVC) meat packaging film at six retail grocery companies in the Seattle, Washington area. Based on medical evidence compiled during this limited study of meat wrapping employees it was determined that air- contaminants generated by the thermal cutting of polyvinyl chloride packaging films in conjunction with the wrapping of meat are potentially toxic to maat wrapping employees. Symptoms range from mild eye, nose and throat irritation to more serious respiratory problems for meat wrappers who have an underlying predisposition to respiratory difficulties. Recommendations have been suggested to management regarding pre-employment examinations and work practices. DESCRIPTORS: ^Hazardous materials, ^Industrial medicine, *Polyvinyl chloride. Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Pyrolysis, Packaging, Hazards, Respiratory diseases, Air pollution IDENTIFIERS: *Occupational Safety and Health Act of 1970, NIOSH R&s 006141 PB-229 709/1 NTIS Prices: PC$4.25/MF$1.45 Coal Mine Combustion Products: Identification and Analysis Ultrasystems, Inc., Irvine, Calif. (407 617) Annual rept. FY 1972-73 AUTHOR: Paciorek, K. L., Kratzer, C2314G2 FID: 7D, 21B, 81, USGRDR7406 Aug 73 160p REPT NO: SN-8220/A1 CONTRACT: H0133004 MONITOR: EuMines-OFR-8-7 4 R. H. , Kaufman, J. , Nakahara, J. 111, 11L, 48A, 710, 99F, 81A, H. 71R ABSTRACT: The toxic products formed during thermal oxidative degradation of neoprene and polyvinyl chloride compositions, urethane foams and various untreated and treated woods were determined quantitatively on a g/g basis. Quiescent and dynamic decomposition conditions were employed. Analyses were performed using high vacuum separations, gas chromatography, mass spectrometry, infrared spectroscopy, and wet chemical methods. The main toxic species found were among others CO, HC1, HCN, S02, anhydride, aniline, and furfural. Thermogravimetric analyses were performed on all the compositions, and the data were correlated to. available formulating information and product formation. DESCRIPTORS: ^Combustion products, *Plastics, *ffood, *Coal mining. Mining equipment, Chloroprene resins, Polyvinyl chloride. Polyurethane resins. Carbon monoxide. Decomposition reactions. Hydrogen chloride. Sulfur dioxide. Hydrogen cyanide. Anhydrides,'Anilines, Furfurals, Toxicity, Thermal analysis. Gas chromatography. Mass spectroscopy, Chemical analysis. Oxidation, Safety, Organic compounds IDENTIFIERS: BM PB-226 944/7 NTIS Prices: PCS 11.00/MFS1.45 R&S 006142 72 A Toxicological Evaluation of Certain Heparin-Quaternary Ammonium Complexes Battelle Columbus Labs., Ohio. (407 080) Annual rept. 1 Oct 72-30 Nov 73 AUTHOR: Grode, G. A., Crowley, J. P. , Falb, R. D. , Leininger, B. I. C2313K1 FLD: 6T, 6L, 7C, 57Y*, 95A*, 99C USGRDB7406 26 Dec 74 33p* CONTRACT: PHS-73-2918 MONITOR; 18 ABSTRACT: Physical and chemical characterizations show that the heparin-quaternary ammonium salt complexes can be reproducibly prepared from a given lot of a quaternary ammonium salt. Local toxicity studies also indicate that both the tridodecyl methyl ammonium chloride-heparin and tricapryl methyl ammonium chloride-heparin complexes elicit qualitatively similar responses, while quantitatively, the TCMAC-heparin complex produced a locally more severe response. Single-dose toxicity studies of the heparin complexes, carried out in mice, show that the TDMAD-heparin complex is the more toxic with an LD50 value of 3.3 mg/kg, as compared to an LD50 of 195 mg/kg for the TDMAC-heparin complex. This toxicity gradient is perhaps the reflection of increasing solubility of the complexes in the biological medium with the (C9) capryl-based heparin complex (TCMAC-heparin) being the most soluble. Experimental evidence indicates that the toxicity of TDMAC-heparin treated poly (vinyl chloride) devices is very low. DESCRIPTORS: *Heparin, ^Mechanical organs, *ttechanical hearts. Surface properties. Toxicology, Blood plasma. Plastic coatings. Ammonium compounds. Polyvinyl chloride. In Yitro analysis. Anticoagulants, Surface chemistry IDENTIFIERS: ^Quaternary ammonium salts, *Blood compatible materials, Ammonium/methyl-tridodecyl, Ammonium/methyl-tridecanoyl, NHLI PB-226 886/0 NTIS Prices: PC$3.25/MFS1.45 J3 R&S 006144 Toxicology of Plastic Devices Having Contact With Blood Utah Univ., Salt Lake City. (326 900) Interim rept. for 24 Aug 72-15 Sep 7.3 AUTHOR: Petersen, Robert V., Lyman, David J., Roll, David B. , Swinard, Ewart A. C1901C4 FLD: 6T, 6L, 57T*, 95A*, 95C USGRDR732 4 Sep 73 117p* CONTRACT: NIH-NHLI-73-2908-B MONITOR: NIH/NHLI-72-6 ABSTRACT: The project is primarily concerned with toxicological evaluation of polyvinyl chloride and, more specifically, the commonly used plasticizer, di (2-ethylhexyl) phthalate (DEHP) . The project is divided into twelve tasks including an organizational phase. Plastic composition studies, acute toxicity studies, tissue culture studies, subacute toxicity studies, metabolite identification, teratogenic studies, neurologic studies, larger animal studies, analyses of human blood exposed to plastics during hospital procedures, and possible statistical analysis of human patients following extensive exposure of blood to plastics. Selected findings indicate that: DEHP is poorly absorbed from i.p. - intraperitoneal administration of massive doses; the 30-day subacute i.v. = intravenous LD50 of DEHP in mouse serum is 355 mg/kg in mice; DEHP accumulates in lungs of dogs for at least 2 weeks during daily i.v, = intravenous administration; an efficient method for analyzing DEHP by gas chromatography utilizing an internal standard has been developed; and some components of renal dialysis and cardiac bypass units are toxic to L929 cells by tissue culture methods. Portions of this document are not fully legible. DESCRIPTORS: (*Plastics, Blood), (Toxicology, Plastics), ( Plasticizers, Toxicology) , Medical supplies. Polyvinyl chloride. Addition resins. Elastomers, Thermoplastic resins. Tissue culture. Medical equipment, Mechanical organs. Experimental data, Phthalates, Bioassay, Humans, Laboratory animals IDENTIFIERS: Phthalic acidbis(ethylhexy1-ester) , materials, *Blood compatible materials, NHLI Biocompatible PB-224 558/7 NTIS Prices: PC$4.25/MFS1.45 7 4' Incineration of Plastics Found in Municipal Wastes Syracuse Univ. Research Corp., N.Y. (339 750) Final rept. AUTHOR: Heimburg, R, W., Colella, A. R., Jones, D., Rausch, J. H., Macrina, M. C1725L1 FLD: 13B, 68C*, 68A USGRDR7 322 Sep 73 246 p* GRANT: EP-00304 MONITOR: 2PA-670/2-73-087 ABSTRACT: The purpose of this project was to determine the combustion efficiency of plastics when burned in several types of laboratory incinerators. These laboratory units were designed to simulate the primary flame zones of municipal incinerators. The parameters of efficiency considered were: Percent of material consumed, the chemical cleanliness1 of the gaseous effluent, the rate of production of flyash, and the more obvious environmental effects of the gaseous effluent, flyash, and residue-ash. Several pure resins were burned individually in several laboratory incinerators. Also, several mixtures of plastics and a garbage recipe were burned. Results are presented here from analyses of the effluent along with the effects of each effluent on rats and plants for 1- to 8-hour exposures. DESCRIPTORS: (*Plastics, Combustion), (Solid waste disposal. Plastics), (Incinerators, Plastics) , Garbage, Fly ash. Air pollution. Combustion products. Polyethylene, Polystyrene, Polyvinyl chloride. Acrylonitrile copolymers. Polypropylene, Polycarbonate resins. Polyurethane resins. Urea formaldehyde resins. Melamines, Toxicology, Rats, Plants (Botany) IDENTIFIERS: NERC PB-223 651/1 NTIS Prices: PC$5.75/MFS1.45 30 to o o 75 CD Ol Combustion products from the Incineration of Plastics Michigan Univ., Ann Arbor, School of Public Health, final rapt. AUTHOR: Boettner, 2. A.f Ball, C1501 A3 FLD: 13B, 7C, 68C*, 1973 154p* CONTRACT: EP-00386 - MONITOR: EPA-67C/2-7 3-049 G. L., Weise, B. 68A, 59H USGRDR7319 ABSTRACT: Analysis of the combustion products of plastics was undertaken to provide scientists and engineers with information needed to design incinerators in order to maximize their efficiency while minimizing maintainance and pollution, to identify products of incomplete combustion potentially recoverable for their fuel or crude chemical value; and to identify products of incomplete combustion which would be acutely toxic in an accidental fire. Plastics studied were polyvinyl chloride, polysulfone, polyurethanes, polyimide, Lopac, Barex, phenol formaldehyde, urea formaldehyde, polyethylene, polypropylane, polystyrene, polycarbonate, polyphenylene oxide, polyester, synthetic fabrics (Dacron, Orion, nylon), and natural products (wood and wool) . (Modified author abstract) DESCRIPTORS: (*Plastics, ^Combustion products), (Air pollution. Combustion products) , (*Incinerators. Air pollution) , (*Solid waste disposal, Plastics), Decomposition reactions. Incinerators, Chemical analysis, Gas chromatography. Infrared spectroscopy. Mass spectrometers. Data, Polyvinyl chloride, Thermogravimetric analysis. Polyurethane resins, Polyimide resins. Urea formaldehyde resins-, -Polyethylene, Polypropylene, Polystyrene, Polycarbonate resins. Polyester resins IDENTIFIERS: NERC P3-222 001/0 NTIS Prices: PC$8.00/MFS1.45 R&S 006146 76 * Coal Mine Combustion Products, identification and Analysis Ultrasystems, Inc., Irvine, Calif. (407 617) Final rept. 0 Jul 71-7 Jul 72 AUTHOR: Paciorek, K. L. , Kratzer, C0345E2 FLD: 111, 7C, 81, 710, Jul 72 165p* CONTRACT: H0122009 MONITOR: BuMines-OFR-1-73 R. H., Kaufman, 71H, 57H, 641 J. USGRDR7305 30 Q (/> Oo CD 4"*4 ABSTRACT: Little data is available on oxidative degrative -behavior of materials used in coal mines under truly dynamic conditions approximating the mine environment. However, because of the possible danger involved with the formation of toxic gases, the authors studied the decomposition of various materials. Tests were performed on: Polyvinyl chloride-containing materials; Neoprene compositions; Rigid foams (urethanes, isocyanates); Miscellaneous materials (including jute, fiber glass and polyethylene) using a stagnation burner arrangement. It was found that the chlorine-containing materials evolved hydrogen chloride very readily, its rate of evolution being strongly temperature dependent. The fluorocarbon propellant and C02 were the main products found on decomposition of the foams, whereas among other products jute compositions liberated methyl chloride. The analyses were performed using mass spectrometry and infrared spectroscopy. A review of the combustion products of various polymers is also included. * DESCRIPTORS: (^Combustion products, *Polymers), {Coal mines, Fire safety), (Polyvinyl chloride. Combustion products), (Chloroprane resins. Combustion products), (Cellular plastics. Combustion products ), (*Jute, Combustion products), (*polyurethane, Combustion products). Glass fibers. Polyethylene, Smoke, Gas analysis. Hazardous materials. Infrared spectroscopy, Mass spectroscopy. Decomposition, Reviews, Cellulose, Polyamide resins, Polyester resins, Epoxy resins. Toxicology, Corrosive gases IDENTIFIERS: Mine safety PB-214 124/0 NTIS Prices: PCS6.00/MFS0.95 77 R&S 006148 Chemical and Physical properties and Thermal Decomposition Products of Certain Natural Products and Synthetic Materials Environmental Health Lab Kelly AFB Tex (300925) Technical rept. AUTHOR: Melvin, Walter W. C0072X2 FLD: 111, 11E, May 72 170p* REPT NO: EHL (K) -72-14 PROJECT: EHL-70-7 MONITOR: 18 Jr 13L, 710, 71H, 711, 83C USG3DR73Q2 ABSTRACT: A limited review of the literature including the early history and current data on deaths, injuries and costs due to the combustion and pyrolysis of resins, plastics and natural materials is provided. There is a limited discussion of the chemistry and physical properties of plastics. Applications of these materials in wearing apparel, construction trades, the aircraft industry, and others are discussed. Experimental data on the pyrolysis products of five synthetic and natural fiber carpets are presented. An extensive collection of tables from a number of sources give data on the trade name, type of plastic and manufacturer,1 physical and chemical properties, decomposition products, and other information. (Author) DESCRIPTORS: (Plastics, *Combustion), (Textiles, Combustion), ( .Floor coverings. Combustion) , Reviews, Burning rate. Toxicity, Clothing, Nylon, Corrosive gases. Fire resistant materials. Pyrolysis, Thermal properties. Woolen textiles. Polyvinyl chloride. Plasticizers, Carbon monoxide IDENTIFIERS: Fire safety, Carpets, Flammability testing, Smoke, Hydrogen chloride. Hydrogen cyanide AD-751 899 NTIS Prices: PC$3.00/MFS0. 9 5 7Q Materials Based on Polyvinylchloride for Packaging Food products (Materialy na osnove Polivinilkhlorida dlya Upakovki PishcheryXh Prod uktu v) Army Foreign Science and Technology Center Charlottesville Va 038300) AUTHOR: Chantseva, A. S., Chernovskaya, R. P., Ovchinnikov, Yu. V. A2752E3 FID: 1IX, 13D, 52D, 710 USGRDR7119 14 Jul 71 lOp ' REPT NO: FSTC-HT-23-886-71 Trans, from Plasticheskie Massy (USSR) n6 1970. ( ABSTRACT: The physical, mechanical and toxic properties of various types of polyvinyl chloride films suitable for use as food wrapping materials are presented. (Author) DESCRIPTORS: (Polyvinyl chloride, *Packing materials), (Food, Packing materials). Films, Mechanical properties. Toxicity, Additives, Thermal stability. Viscosity, Tensile properties, USSR IDENTIFIERS: *Food packaging, *polymeric films. Translations AD-728 150 NTIS Prices: PCS3.00 MFSC.95 R&S 006149 79 OSi-900 SSfcf * #* ON THE QUESTION OF IMPROVING SOME POLYVINYL CHLORIDE POLYMERS AND l METHOD OF IMPROVING THEIR TOXICITY Air Force Systems Command, Wright- Patterson AFB, Ohio. Technology Div. AUTHOR: Gorban, G. M. ' 6011F1 FLD: 11G STAR0709 Apr 68 13p REPT NO: AD-6809'24, FTD- HT-23-1464-67 Tran- Transl. Into English- From Kosmich. Biol. Med. (USSR) , 2, 1967 P 47-51 Fore.^^ V. 1, No. DESCRIPTORS: ^Electrical properties, ^Plastic tapes, *Polyvinyl chloride, *Ureas, Degassing, Electrical insulation. Nitrogen compounds N69-20342 CFSTI Prices: PCS3.00 MFS0.95 ABSTRACT: A method is developed for improving the polyvinyl chloride tapes for the purpose of decreasing their gas emanation. The overall gas emission of organic substances from the improved specimens of polyvinyl chloride tapes as a result of the treatment with 5C% urea solution is reduced by a factor of 2-1 /2. The improved polyvinyl chloride tapes give off volatile chemical substances in small concentrations, which with long duration of their action on the organism cause only a weak biilogical effect. As a result of the treatment with a solution of urea there is an improvement in the electrical insulation properties of the polyvinyl chloride tapes serving the purpose for which the materials are intended without change in their strength characteristics. 80 THE EFFECTS OF STORAGE CONDITIONS OF PLASTIC BLOOD CONTAINEBS ON THE ANTICOAGULANT- (ACD) AND THE PRESERVATION OF WHOLE BLOOD AND ITS DERIVATIVES Texas Univ., Austin. Drug Plastic Research and Toxicology Lab. Terminal rept. AUTHOR: Guess, Wallace L. 584212 FID: 6L, 6T, 13D 196 8 4 Ip* CONTRACT: PH-43-68-97 USGRDR6909 ABSTRACT: On the basis of this study, it vas concluded that there is clear evidence of a toxicity potential from some PVC blood bags currently available. There is insufficient evidence at the present time to evaluate the effects of storage conditions beyond a one year period, but the study indicated no drastic alterations due to the one year storage period at temperatures up to 50 degrees C. (Author) DESCRIPTORS: (*Blood, Storage), (*Bags (Containers) , Blood), ( Polyvinyl chloride. Toxicity), Plastics, Bags (Containers) , Anticoagulants, Preservation, Mice, Rabbits, Chromatographic analysis. Temperature, Pathology PB-182 732 CFSTI Prices: PCS6.00 MFS0.95 R&S 006152 ON THE QUESTION OF IMPROVING SOME POLYVINYL CHLORIDE POLYMERS AND A METHOD OF IMPROVING THEIR TOXICITY Foreign Technology Div ffright-Patterson AFB Ohio AUTHOR: Gorban, G. M. , Yabl ochkin, V. D. 5603E1 FLD: 111, 22A USGRD R 6 90 6 15 Apr 63 12p BEPT NO: FTD-HT-23-1464-67 Unedited rough draft trans. of Kosraicheskaya (USSR) v 1 n2 p47-51 1967, by E. Harter. (141600) Biologiya i -- Meditsina ABSTRACT: A method is developed for 'improving* the polyvinyl chloride tapes for the purpose of decreasing their gas emanation. The overall gas emission of organic substances from the 'improved* specimens of polyvinyl chloride tapes as a result of the treatment with.50% urea solution is reduced by a factor of 2 1/2. The 'improved* polyvinyl chloride tapes give off volatile chemical substances in small concentrations, which with long duration of their action on the organism cause only a weak, biological effect. As a result of the treatment with a solution of urea there is an improvement in the electrical insulation properties of the polyvinyl chloride tapes serving the purpose for which the materials are. intended without change in their strength characteristics. (Author) DESCRIPTORS: (*Polyvinyl chloride. Processing), Tapes, Gases, Urea, Spacecraft cabins. Carbon dioxide. Aldehydes, Carbon monoxide. Hydrocarbons, Toxicity, Degasification, USSR IDENTIFIERS: Translations AD-630 924 CFSTI Prices: PCS3.00 MFS0.95 82' MAIL ORDER TO: National Ttehnicil Informitian Sarvica U.S. DEPARTMENT OF COMMERCE 5ormgfild, Vi. 22161 17031 557-1630 TELEX BS-O'iOS PURCHASER: T-tleonon,: For OOC Uian Only DOC Usar Coda_______ Contract Numo.r,______ (lait 3 ciiarietarj only). i raaaury Agtncy '.station t_oa ! 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