Document LJq86eKKkxJRq1a35ZY4d2jJ7

RICHARD ALLEN CORLEY. Ph.D. TITLE: Research Associate PRESENT POSITION: Technology Leader of The Inhalation Toxicology Research Laboratory BUSINESS ADDRESS: The Toxicology Research Laboratory The Dow Chemical Company 1803 Building Midland, Michigan 48674 TELEPHONE NUMBER: 517-636-1318 DATE OF BIRTH: 21 March 1957 MARITAL STATUS: Married CHILDREN: Two EDUCATION Ph.D. (1985) B.A. (1979) University of Illinois at Urbana-Champaign. Major: Environmental Toxicology. Minor: Analytical Chemistry Doctoral Thesis: The Metabolic Fate of Tritium-Labeled T-2 Toxin, a Trichothecene Mycotoxin, in Swine University of Missouri at Columbia. Major. Biology. Minor: Chemistry. PROFESSIONAL AFFILIATIONS American Association for the Advancement of Science, Student Member (1983-1985). American Chemical Society, Student Member (1983-1986). Michigan Chapter of The Society of Toxicology (1993-Present). Society of Toxicology, Full Member (1992-Present). 12/04/95 BFG41248 BFG 00761 R.A. Corley Page 2 AWARDS AND RECOGNITION Special Recognition Award (Dow) (March, 1987) 1994 Health and Environmental Sciences (Dow) Excellence in Science Award (Nov., 1994) EMPLOYMENT 12/95-Present 7/93-12/95 5/91-7/93 Research Associate. The Toxicology Research Laboratory, The Dow Chemical Company, Midland, Michigan 48674. Consulting toxicologist for the Chemicals and Performance Products (C&PP) businesses. Responsible for coordinating C&PP activities within the Health and Environmental Sciences department, respond to issues related to toxicology and interact with product stewards, business and product management teams, customers, trade associations and regulatory agencies as the toxicology representative of the business. Laboratory leader in the development and application of physiologically-based pharmacokinetic (PB-PK) models in risk assessment Also responsible for scientific activities and strategic direction of the inhalation toxicology laboratory as well as mentoring and developing scientific expertise within the laboratory. Principle study director and scientific reviewer for R & D reports. Supervisor J.S. Bus. Research Leader. The Toxicology Research Laboratory, The Dow Chemical Company, Midland, Michigan 48674. Job description: same as above. Research Leader. The Toxicology Research Laboratory, The Dow Chemical Company, Midland, Michigan 48674. Group Leader of The Inhalation Toxicology Research Laboratory. Responsible for planning and budgeting research activities, personnel development, strategic direction and laboratory operations. Principle study director and scientific reviewer for R & D reports. Additional responsibilities included scientific input into toxicology-related issues and development of physiologically-based pharmacokinetic models. Supervisor. J.S. Bus. 12/04/95 BFG41249 BFG 00762 R.A. Corley 12/90-5/91 4/89-12/90 12/88-4/89 6/87-12/88 10/85-6/87: Page 3 Project Leader. The Toxicology Research Laboratory, The Dow Chemical Company, Midland, Michigan 48674. Job description: same as above. Project Leader. The Toxicology Research Laboratory, The Dow Chemical Company, Midland, Michigan 48674. Group Leader of the Chronic Toxicology Research Laboratory. Responsible for planning and budgeting research activities, personnel development and laboratory operations. Also involved in the design and conduct of studies, data analysis, development of physiologicallybased pharmacokinetic models, report writing and scientific reviewer for R & D reports. Additional responsibilities for scientific input into toxicology-related issues for the Chemicals and Performance Products department Supervisor: P.G. Watanabe. Project Leader. The Toxicology Research Laboratory, The Dow Chemical Company, Midland, Michigan 48674. Research toxicologist in the inhalation/dermal toxicology research group. Responsible for protocol design, study implementation, data analysis, report writing and quality assurance in support of discovery stage compounds and product registration. Experience in state-of-theart inhalation equipment, atmospheric analyses, computer monitoring, metabolism studies, dermal studies and physiologically- based pharmacokinetic modeling. Competent in HPLC, GLC, LSC and IR techniques and the use of computers for data acquisition and analysis. Additional responsibilities as toxicology consultant for the Chemicals and Performance Products department Supervisors: T.D. Landry and P.G. Watanabe. Senior Research Toxicologist The Toxicology Research Laboratory, The Dow Chemical Company, Midland, Michigan 48674. Job description: same as above. Post-Doctoral Fellow. The Toxicology Research Laboratory, The Dow Chemical Company, Midland, Michigan 48674. Position as research toxicologist in the inhalation/dermal research group. Designed and conducted studies on the mechanism of action of organo-metalics and halogenated solvents, in addition to inhalation, dermal and physiologically-based pharmacokinetic studies in support of product registration. Supervisors: R.R. Miller and P.G. Watanabe. 12/04/95 BfG41250 BFG 00763 R.A. Corley Page 4 8/80-10/85: 8/79-8/80: Graduate Research Assistant in Environmental Toxicology. Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois, Urbana, Illinois 61801. Graduate education emphasizing the areas of environmental, veterinary and natural products toxicology. Specific research interests in metabolism and kinetics of trichothecene mycotoxins in domestic animals. Experience with radiotracers, fungal culture, GLC, TLC, HPLC, GPC and spectroscopic techniques. Supervisors: W. B. Buck and S. P. Swanson. Student Technician. Analytical Toxicology, Veterinary Medical Diagnostic Laboratory, University of Missouri, Columbia, Missouri 65201. Responsible for the analysis of animal feeds, tissues and environmental samples for chemicals and metals in support of the Diagnostic Laboratory. Experience with UV, IR, GLC, HPLC, TLC and AAS techniques. Supervisors: G.D. Osweiler and G.E. Rottinghaus. PROFESSIONAL EXPERIENCE MANAGEMENT OF TOXICOLOGY RESEARCH. Supervisor of the subchronic/chronic dietary toxicology laboratory (1989-1990) and the inhalation toxicology laboratory (1990-1993). Technical Leader of the inhalation toxicology laboratory (1993-present). TECHNICAL R&D REPORTS. Authored or co-authored over 20 reports including: subchronic dermal toxicity studies, acute-to-subchronic inhalation studies, inhalation teratology studies, subacute-to-chronic dietary toxicity/oncogenicity studies, metabolism studies and physiologically-based pharmacokinetic studies. Species studied include: mice, rats, humans, rabbits and dogs. ONGOING RESEARCH. Chronic rat and mouse inhalation studies, mechanistic (enzyme kinetics, cell proliferation, etc.) and physiologically-based pharmacokinetic and pharmacodynamic model development. CONSULTING. Toxicology Consultant, Organic Chemicals, The Dow Chemical Company (1988-1990; 1993-Present). Member of the Toxicology Research Task Group, Ethylene Glycol Ethers Panel, Chemical Manufacturers Association (1988-1990; 1993-Present); Toxicology Research Task Group, Propylene Glycol Ethers Panel, 12/04/95 BFG41251 BFG 00764 R.A. Corley Page 5 Chemical Manufacturers Association (1993-Present); Ethylene Oxide Industry Council, Chemical Manufacturers Association (1989-1990); Water Quality Technical Committee of the ILSI Health and Environmental Sciences Institute (1995-Present). INVITED WORKSHOPS AND ADVISORY PANELS 1. EPA/ILSI Workshop: Principles of Route-to-Route Extrapolations for Risk Assessment March 20,1990. Hilton Head, SC. (Speaker). 2. ATSDR Decision Support Methodologies for Hazard Identification/Risk Assessment of Toxic Substances. Atlanta, GA. October 18-20, 1993. (Expert Panelist). 3. EPA/AIHC/ILSI Workshop: Human Variability. October 16-17, 1995. Washington, D.C. (Participant). 4. EPA/CMA Working Group: IRIS RfC/RfD Process for Ethylene Glycol n-Butyl Ether and Diethylene Glycol n-Butyl Ether. September, 1995 - Present. (Participant). 5. CIIT Technical Advisory Panel: MTBE Research Program. September, 1995 Present. (Participant). PUBLICATIONS 1. Gas Chromatographic Method for the Determination of Diacetoxyscirpenol in Swine Plasma and Urine. S.P. Swanson, L. Terwell, R.A. Corlev. J. Chromatog. 248: 456-460,1982. 2. Apparent Blue-Green Algae Poisoning in Swine Subsequent to Ingestion of a Bloom Dominated by Anabaena Spiroides. V.R. Beasley, R.W. Coppock, J. Simon, R. Ely, W.B. Buck, R.A. Corlev. D.M. Carlson, P.R. Gorham. JAVMA 182(4): 413-414,1983. 3. Rapid Thin-Layer Chromatographic Method for the Determination of Zearalenone and Zearalenol in Grains and Animal Feeds. S.P. Swanson, R.A. Corlev. D.G. White, W.B. Buck. JAOAC 67(3): 580-582,1984. 4. Glucuronide Conjugates of T-2 Toxin and Metabolites in Swine Bile and Urine. R.A. Corlev. S.P. Swanson, W.B. Buck. J. Agric. F(L Chem. 33: 1085-1089, 1986. 12/04/95 BFG 00765 R.A. Corley Page 6 5. Pharmacokinetics of the Trichothecene Mycotoxin, T-2 Toxin, in Swine and Cattle. V.R. Beasley, S.P. Swanson, R.A. Corlev. W.B., Buck, G.D. Koritz, H.R. Burmeister. Toxicon. 24(1): 13-23,1986. 6. Disposition of T-2 Toxin, a Trichothecene Mycotoxin, in Intravascularly-Dosed Swine. R.A. Corlev. S.P. Swanson, GJ. Gullo, L. Johnson, V.R. Beasley, W.B. Buck. J. Agric. FcL Chem. 34: 868-875, 1986. 7. Disposition of Trichothecene Mycotoxins. S.P. Swanson. R.A. Corlev. In "Trichothecene Mycotoxicosis: Pathophysiologic Effects". V.R. Beasley, Ed. CRC Press, Inc. 1988. 8. Chlorpyrifos: A 13-Week Nose-Only Vapor Inhalation Study in Fischer 344 Rats. R.A. Corlev. L.L. Calhoun, D.A. Dittenber. L.G. Lomax, T.D. Landry. Fund Appl. Toxicol. 13, 616-618,1989. 9. Development of a Physiologically-Based Pharmacokinetic Model for Chloroform. R.A. Corlev. A.L. Mendrala, F.A. Smith, M L. Gargas, D.A. Staats, R.B. Conolly, M.E. Andersen, and R.H. Reitz. Toxicol. Appl. Pharmacol. 103, 512-527, 1990. 10. Estimating the Risk of Liver Cancer Associated With Human Exposures to Chloroform. R.H. Reitz, A.L. Mendrala, R.A. Corlev. J.F. Quast, M.L. Gargas, M.E. Andersen, D.A. Staats, and R.B. Conolly. Toxicol Appl PharmacoL 105, 443-459,1990. 11. Dose-Route Extrapolations in Quantitative Toxicology: Physiologically-Based Pharmacokinetics and Pharmacodynamics of Chloroform. R.A. Corlev and R.H. Reitz. In "Principles of Route-to-Route Extrapolation". T.R. Gerity and C.J. Henry, Eds. Elsevier, NY. 1990. 12. Physiologically-Based Pharmacokinetics of 2-Butoxyethanol and its Major Metabolite, Butoxyacetic Acid, in Rats and Humans. R.A. Corlev. G.A. Bormett andB.I. Ghanayem. Toxicol Appl. Pharmacol. 129,61-79,1994. 13. Multiple Endpoints: Integrated Strategies and Contemporary Issues In Animal Assays for Existing Chemicals. h' D Knvanek and R.A. Corlev. In "Screening and Testing Chemicals in Commerce" U S Congress, Office of Technology Assessment, OTA-BP-ENV-166 September, 1995. 14. Adaptive Metabolic and Pathologic Changes Following Chronic Inhalation of Propylene Glycol Monomethyl Ether in Rats and Mice. R.A. Corlev. J.W. Crissman, J.R. Redmond, R.J. McGuirk. F S. Cieszlakand W.T. Stott. Occ. Hyg. In press. 12/04/95 BFG41253 BFG 00766 R.A. Corley Page 7 15. Evaluation of the Developmental Toxicity of Inhaled Dipropylene Glycol Monomethyl Ether (DPGME) in Rabbits and Rats. WJ. Breslin, F.S. Cieszlak, C.L. Zablotny, R.A. Corlev. H.G. Verschuuren and B.L. Yano. Occ. Hyg. In press. 16. Toxicology of Diethylene Glycol Butyl Ether; Exposure and Risk Assessment R. Gingell, RJ. Boatman, R.A. Corlev. J.B. Knaak, K.A. Rosica, R.C. Wise. Occ. Hyg. In press. 17. Assessing the Risk of Hemolysis in Humans Exposed to 2-Butoxyethanol Using a Physiologically-Based Pharmacokinetic Model R.A. Corlev. Occ. Hyg. In press. 18. Subchronic Oral and Dermal Toxicity/Ncurotoxicity of Triethylene Glycol Monomethyl Ether in Rats. Manuscript in preparation. 19. Physiologically-Based Pharmacokinetics of the Dermal Absorption of 2Butoxyethanol Vapors in Humans. Manuscript in preparation. ABSTRACTS AND PROCEEDINGS 1. Rapid Thin-Layer Chromatographic Method for the Determination of Zearalenone and Zearalenol in Com. R.A. Corlev. S.P. Swanson, D.G. White, W.B. Buck. Abst #190. 95th An. Meeting Assoc, of Official Anal. Chem. October, 1981. Washington, D.C. 2. Toxicokinetics and Toxicodynamics of T-2 Toxin in Swine and Cattle. V.R. Beasley, W.B. Buck, S.P. Swanson, J.R. Szabo, R.A. Corlev. Abst #18. 16th An. Meeting Amer. Chem. Soc., Great Lakes Region. June, 1982. Normal, IL. 3. Gas Chromatographic Method for the Determination of Deoxynivalenol (Vomitoxin) in Swine Plasma and Urine. S.P. Swanson, R.A. Corlev. R.F. Vesonder, W.B. Buck. Proceed. 96th An. Meeting Assoc, of Official Anal. Chem. October, 1982. Washington, D.C. 4. Current Status of Toxicokinetics and Residue Detection of Trichothecene Mycotoxins in Swine, Cattle and Feedstuffs. V.R. Beasley, S.P. Swanson, J.D. Reynolds, R.W. Coppock, R.A. Corlev. L.M. Cote, W.B. Buck. Proceed. 86th An. Meeting U.S. Animal Health Assoc. November, 1982. Nashville, TN 5. Analysis of Deoxynivalenol (Vomitoxin) in Plasma and Urine. S.P. Swanson, R.A. Corlev. R.F. Vesonder, J.D. Reynolds, L.M. Cote, R.W. Coppock, W.B. Buck. Abst. #3. 25th An. Meeting Amer. Assoc, of Vet. Lab. Diagnosticians. November, 1982. Nashville TN. 12/04/95 BFG 00767 R.A. Corley Page 8 6. Metabolism of T-2 Toxin in Swine. R.A. Corlev. S.P. Swanson, R.H. Poppenga, W.B. Buck. Abst #42. 187th Nat Meeting Amer. Chem. Soc. April, 1984. Sl Louis, MO. 7. Metabolism and Distribution of Tritium-Labeled T-2 Toxin in Swine. R.A. Corlev. S.P. Swanson, W.B. Buck. Conference on Toxicity and Therapy of Trichothecene Mycotoxicosis. FASEB Summer Research Conferences. June, 1984. Saxtons River, VT. 8. Chlorpyrifos: 13-Week Nose-Only Vapor Inhalation Study In Fischer 344 Rats. R.A. Corlev. T.D. Landry, L.L. Calhoun, D.A. Dittenber, L.G. Lomax. Abst #190. 26tlr An. Society of Toxicology Meeting. February, 1987. Washington, D.C. 9. A Physiologically-Based Pharmacokinetic Model for Chloroform. R.A. Corlev. A.L. Mendrala, F.A. Smith, M.L. Gargas, R.B. Conolly, M.E. Andersen, and R.H. Reitz. Abst #948. 28th An. Society of Toxicology Meeting. February, 1989. Atlanta, GA. 10. Developmental Toxicity of Inhaled Dipropylene Glycol Monomethyl Ether (DPGME) in Rabbits and Rats. WJ. Bresiin, F.S. Cieszlak, C.L. Zablotny, R.A. Corlev. B.L. Yano and H.G. Verschuuren. Abst. #154. 29th An. Society of Toxicology Meeting. February, 1990. Miami, FL. 11. A PB-PK Risk Assessment for Chloroform. R.H. Reitz, R.A. Corlev. A.L. Mendrala, J.F. Quast, M.E. Andersen, M.L. Gargas, R.B. Conolly and D.A. Staats. Abst #285. 29th An. Society of Toxicology Meeting. February, 1990. Miami, FL. 12. Descriptive Toxicology. In: "Mammalian and Environmental Toxicology - An Overview". J.M. Waechter, R.A. Corlev and M.A. Mayes. Abst #72-75. American Chemical Society, Central Region. June, 1990. University Center, MI. 13. Toxicology of Diethylene Glycol Butyl Ether 1. Exposure and Risk Assessments. R. Gingell, W.J. Krasavage, T.R. Tyler, J.B. Knaak, R.A. Corlev. J.H. Sayler and C.A. Stack. Abst # 1223. 30th An. Society of Toxicology Meeting. February, 1991. Dallas, TX. 14. Rat and Mouse Liver and Kidney Response to Inhaled Propylene Glycol Monomethyl Ether (PGME). J.S. Bus, J.W. Crissman, T.R. Fox, J.M. Redmond, F.S. Cieszlak, R.A. Corlev and W.T. Stott. Abst. #871. 31st An. Society of Toxicology Meeting. February, 1992, Seattle, WA. 12/04/95 BFG41255 BFG 00768 R.A. Corley Page 9 15. The Subchronic Toxicity of Triethylene Glycol Monomethyl Ether (TGME) in DermaUy-Exposed Sprague-Dawley Rats. R.A. Corlev. F.S. Cieszlak, WJ. Breslin, L.G. Lomax and C.R. Stack. Abst. #868. 31st An. Society of Toxicology Meeting. February, 1992, Seattle, WA. 16. Triethylene Glycol Monomethyl Ether (TGME): Ninety-Day Subchronic Drinking Water Inclusion Neurotoxicity Study in Rats. P.E. Losco, M.W. Gill, J. P. Maurissen. R.A. Corlev. R. Gingell and C.R. Stack. Abst #869. 31st An. Society of Toxicology Meeting. February, 1992, Seattle, WA. 17. Subchronic Dietary Toxicity of 2,4-D Acid, 2,4-D Amine Salts and 2,4-D Esters in Rats. B.L. Yano, G.E. Schultze, J.R. Szabo, R.A. Corlev. P.F. Cosse and L.H. Billups. Abst #404. 31st An. Society of Toxicology Meeting. February, 1992, Seattle, WA. 18. A Physiologically-Based Pharmacokinetic Model for 2-Butoxyethanol and its Metabolite, Butoxyacetic Acid. R.A. Corlev. G.A. Bormett, B.J. Markley and C.R. Stack. Abst. #1387. 32nd An. Society of Toxicology Meeting. March, 1993, New Orleans, LA. 19. Adaptive Metabolic and Pathologic Changes Following Chronic Inhalation of Propylene Glycol Monomethyl Ether in Rats and Mice. R.A. Corlev. J.W. Crissman, J.R. Redmond, R.J. McGuirk. F.S. Cieszlak and W.T. Stott. International Symposium on Health Hazards of Glycol Ethers. Nancy, France. April 19-22, 1994. 20. Evaluation of the Developmental Toxicity of Inhaled Dipropylene Glycol Monomethyl Ether (DPGME) in Rabbits and Rats. W.J. Breslin, F.S. Cieszlak, C.L. Zablotny, R.A. Corlev. H.G. Verschuuren and B.L. Yano. International Symposium on Health Hazards of Glycol Ethers. Nancy, France. April 19-22, 1994. 21. Toxicology of Diethylene Glycol Butyl Ether: Exposure and Risk Assessment. R. Gingell, RJ. Boatman, R.A. Corlev. J.B Knaak, K.A. Rosica, R.C. Wise. International Symposium on Health Hazards of Glycol Ethers. Nancy, France. April 19-22,1994. 22. Physiologically-Based Pharmacokinetics of the Dermal Absorption of 2Butoxyethanol Vapors in Humans. R.A. Corlev. D.A. Markham, C. Banks, P. Delorme, A. Masterman, J.M. Houle and K. A. Rosica. Abst. #255. 34th An. Society of Toxicology Meeting. Baltimore, MD. March, 1995. 23. Analysis of 2-Butoxyethanol and Metabolites in Human Urine by GC & ESI/MS. D.A. Markham, M.J. Bartels, R.A. Corlev. and A.W. Rettenmeier. Abst. #WPG 12/04/95 bFG41256 BFG 00769 R.A. Corley Page 10 170. 43rd ASMS Conference on Mass Spectrometry and Allied Topics. Atlanta, GA. May 21-26,1995. 24. A Physiologically-Based Pharmacokinetic (PBPK) Model for 2-Butoxyethanol and its Hemolytic Metabolite, 2-Butoxyacetic Acid. K.M. Lee, R.D. Stenner, R.A. Corlev. and K.D. Thrall. Abst #63-PF-2. VII Intemadonal Congress of Toxicology. Seattle, WA. July 2-6,1995. 24. Multiple 2-Butoxyethanol Intoxications in the Same Patient: Clinical Findings, Pharmacokinetics and Therapy. J. Gualtieri, C. Harris, R. Roy, R. Corlev and C. Manderfield. North American Congress of Clinical Toxicology. Rochester, NY. September 16-19,1995. 25. Chronic Toxicity, Oncogenicity and Mechanistic Studies with Propylene Glycol Monomethyl Ether (PGME). R.A. Corlev. J.W. Crissman, F.S. Cieszlak and W.T. Stott. Abst.#. 35 th An. Society of Toxicology Meeting. Anaheim, CA. March 10-14, 1996. INVITED PRESENTATIONS 1. Short and Long Range Effects of Pesticides in Agriculture. R.A. Corlev. Quad Cities Chapter, Amer. Soc. of Agric. Eng. November 3,1983. Moline, IL. . 2. The Toxicology of Glycols. R.A. Corlev. Society of Automotive Engineers. August 17,1989. Tulsa, OK.. 3. A Physiologically-Based Pharmacokinetic Model for Chloroform/Chloroform Risk Estimations using PB-PK Models. R.A. Corlev and R.H. Reitz. Interagency Pharmacokinetics Group. October 17,1989. Washington, D.C. 4. A Physiologically-Based Pharmacokinetic Model for Chloroform/Chloroform Risk Estimations using PB-PK Models. R.A. Corlev and R.H. Reitz. American Industrial Health Council. October 17, 1989. Washington, D.C. 5. Dose-Route Extrapolations in Quantitative Toxicology: Physiologically-Based Pharmacokinetics and Pharmacodynamics of Chloroform. R.A. Corlev. EPA/ILSI Workshop: Principles of Route-to-Route Extrapolations for Risk Assessment March 20,1990. Hilton Head, S.C. 6. Physiologically-Based Pharmacodynamic Models in Cancer Risk Assessment R.A. Corlev. U.S.C. Biomedical Simulations Resource Short Course on "Advanced Modeling Methodologies in Pharmacokinetics and Pharmacodynamics". May 17, 1991. Los Angeles, CA. 12/04/95 BFG41257 BFG 00770 R.A. Corley Page 11 7. Physiologically-Based Pharmacodynamic Models in Cancer Risk Assessment R.A. Corlev. University of Pittsburgh Graduate School of Public Health Seminar Series. July 24, 1991. Pittsburgh, PA. 8. Using Physiologically-Based Pharmacokinetic Modeling in Risk Assessments. R.H. Reitz and R.A. Corlev. Short Course for the State of Michigan Department of Natural Resources. September 12, 1991. Lansing, MI. 9. Improvements in Health Risk Assessment: Biologically-Based Models for Tissue Dosimetry. R.A. Corlev. ACS Symposium: "The Role of Mechanistic Data in Regulatory Decisions". 204th National Meeting, American Chemical Society. August 25, 1992. Washington, D.C. 10. A Physiologically-Based Pharmacokinetic Model for 2-Butoxyethanol and its Metabolite, Butoxyacetic Acid. R.A. Corlev. Chemical Manufacturers Association, Glycol Ethers Toxicology Research Task Group. October 14, 1992. Washington, D.C. 11. A Physiologically-Based Pharmacokinetic Model for 2-Butoxyethanol and its Metabolite, Butoxyacetic Acid. R.A. Corlev. U.S.E.P.A. RfC Work Group. February 12, 1993. Research Triangle Park, NC. 12. Improvements in Health Risk Assessment: Biologically-Based Models for Tissue Dosimetry. R.A. Corlev. University of Kentucky Graduate Center for Toxicology Seminar Series. April 5, 1993. 13. Toxicology in the Chemical Industry. R.A. Corlev. University of Kentucky Graduate Center for Toxicology (TOX 680 Advanced Toxicology). April 6,1993. 14. Improving Health Risk Assessments Using Biologically-Based Models for Tissue Dosimetry. R.A. Corlev. Michigan Society for Risk Analysis. Dearborn, MI. October, 26,1993. 15. Improving Health Risk Assessments Using Biologically-Based Models for Tissue Dosimetry. R.A. Corlev. Pharmacokinetics (U.K.). Birmingham, U.K. November 12, 1993. 16. A Physiologically-Based Pharmacokinetic Model for 2-Butoxyethanol and its Metabolite, Butoxyacetic Acid, in Rats and Humans. R.A. Corlev. International Symposium on Health Hazards of Glycol Ethers. Nancy, France. April 19-22, 1994. 12/04/95 BFG 00771 R.A. Corley Page 12 17. Multiple Endpoints. N. Krivanelc and R.A. Corlev. Office of Technology Assessment Workshop on Testing and Screening Technologies for Review of Chemicals in Commerce. Washington, D.C. April 24-25,1995. 18. Physiologically Based Pharmacokinetics of 2-Butoxyethanol: Biological Basis for an Occupational Exposure Limit R.A. Corlev. ACGIH TLV Committee. San Antonio, TX. October 14,1995. 19. Use of Physiologically-Based Pharmacokinetic Modeling as an Approach to Risk Assessment of 2-Butoxyethanol. R.A. Corlev. 1995 Fall Mtg. of the MI Chapter of the Society of Toxicology. Novi, MI. October 20, 1995. 20. Physiologically-Based Pharmacokinetics and the Dermal Absorption of 2Butoxyethanol Vapors by Humans. R.A. Corlev. Pacific Northwest National Laboratory. Richland, WA. November 30, 1995. 12/04/95 BFG41259 BFG 00772