Document LJd14GwmD0z3MvDrVgQ1nZrg5

TOXICOLOGY SUMMARY HEALTH ?< ENVIRONMENTAL SCIENCES T.I.M.E. SYSTEM DR-OOOl-5807 PROPYLENE OXIDE PAGE -W5>/06/8T------irs._____ REPT k NOTES RATIONALE FOR LABEL STATEMENTS: CENTRAL NERVOUS SYSTEM OMITTED AS A TARGET ORGAN ON THE LABEL BECAUSE EFFECTS WERE OBSERVED ONLY AT HIGH LEVELS AND ONLY IN ANIMALS, CATEGORY 3 STATEMENT FOR CARCINOGENICITY "POSSIBLE CANCER HAZARD" USED BECAUSE ALL DATA IS FROM ANIMAL STUDIES; THERE IS NO HUMAN DATA. INFLAMMATION OCCURS PRIOR TO TUMOR FORMATION FOR MANY TUMORS (STOMACH, NASAL TURBINATES). STATEMENT "MAY CAUSE RESPIRATORY TRACT EFFECTS BASED ON ANIMAL DATA" WAS USED TO COVER IRRITATION IN THE UPPER RESP TRACT WHICH PRECEDES TUMOR FORMATION AS WELL AS LUNG EFFECTS OBSERVED.IN SOME SPECIES IN EARLY STUDIES. LUNG EFFECTS PER SE HAVE BEEN DOWNPLAYED BECAUSE THEY ARE NOT REPORTED IN LATER STUDIES. ONLY EYE Z< RESPIRATORY IRRITATION HAVE BEEN REPORTED AS A RESULT OF HUMAN EXPOSURE TO PO, REFERENCES R-l BETSO REVIEW, 1975. R-2 SMYTH, ET AL., AM IND HYG ASSOC J 30(5): 470-6, 1969. R-3 ROWE, ET AL. AMA ARCH IND. HEALTH 13:228-236, 1956. R-4 SMYTH, ET AL., J IND HYG TOXICOL 30:63-8, 1948. R-5 HET K-001709-007, 1982. R-6 FREGERT, ET AL. CONTACT DERMATITIS NEWSLETTER NO. 3, 1970. R-7 JACOBSON, ET AL., ARCH IND HLTH 13:237, 1956. R-3 CIVO INSTITUTES TNO, DIV. FOR NUTRITION AND FOOD RESEARCH, 1931. R--9 CIVO INSTITUTES TNO, DIV. FOR NUTRITION AND FOOD RESEARCH, 1983, 2-YEAR STUDY IN K-1709-(55). PUBLISHED ARTICLE R-27. R-l0 NTP BIOASSAY. TECHNICAL REPORT 267, 1983. R-i1 HACKETT, ET AL., 1932, REPORT TO NIOSH, BATTELLE PACIFIC NORTHWEST. R-12 WADE, D.R., ET AL. MUTAT. RES. 58:217-223, 1978. R-l3 BOOTMAN, J., ET AL. MUTAT. RES. 67:101-112, 1979. R-14 MCMAHON, R.E., CANCER RES. 39:682-693, 1979. R-l5 PFEIFFER, E.H. FOOD COSMET. TOX 13:115-118, 19S0. R-l6 KOLMARK, G. AND GILES, N.H. GENETICS 40:890-902, 1955. R-17 ENVIRONMENTAL HEALTH RESEARCH AND TESTING, INC., 1981, PUBLISHED IN TOX. AF'PL. F'HARM. 76:85-95,1984. R-1B HET K-1709-(6), 1980. R-19 ENVIRONMENTAL HEALTH RESEARCH AND TESTING, INC., 1982. TOXIC ANr MUTAGENIC EFFECTS OF ED AND PO ON THE SPERMATDGENIC FUNCTIONS IN CYNOMOLGUS MONKEYS. R-20 ENVIRONMENTAL HEALTH RESEARCH AND TESTING, INC., 1982. EFFECT OF EO AND POON THE INDUCTION OF MICRONUCLEI IN BONE MARROW ERYTHROCYTES R-21 HET K-1709-(10>, 1985; RAT, 2-GENERATION REPRO STUDY. PUBLISHED IN FAAT 10:82-08, 1988. D0 A 044898 R-22 HET K--1709-011, 1985. CONFIDENTIAL R-23 LYNCH, D., ET AL, TOX AF'F'L PHARM 76:69-84,1984. R-24 PERO, R.W., ET. AL. , CELL BIOL..3. TOX . I (4) : 309-314, 1985. R-25 HET K-l709-12, 1988. R-26 PATTY'S INDUSTRIAL HYGIENE .3 TOX. CHAPTER ON EPOXY COMPOUNDS. VOL. 2A, 19981. * TRADEMARK OF THE DOW CHEMICAL COMPANY RESTRICTED - DOW USE ONLY / / TOXICOLOGY SUMMARY HEALTH S, ENVIRONMENTAL SCIENCES T.I.M.E. SYSTEM PAGE "^j/06/6^ DR-0001-5B27 PROPYLENE OXIDE REFT K. R-27 KUPER, C.F., REUXEL, P.G. J. AND V.J. FERON, FOOD AND CHEMICAL TOXICOLOGY 26: 159-167, 1968. (PUBLISHED ARTICLE- SAME STUDY AS R-9). END OF REPORT; FOR ADDITIONAL INFORMATION CONTACT: CHEMICAL HAZARD EVALUATION & COMMUNICATION HEALTH & ENVIRONMENTAL SCIENCES 1803 BUILDING, MIDLAND, MI 4S674 PHONE' (517) 636-1909 * TRADEMARK OF THE DOW CHEMICAL COMPANY RESTRICTED DOW USE ONLY