Document LJB5w7Rwx04EmmQ1wZNQxX9GQ

: 937ff vera1 1110 AR 226_ 06H FL-0700 1378 i WERE pg 3M July 24,2000 Con: i. ALB ADtotnc:umSeencttiPornoce(se)siCnogorCdeinntaetro(r7407) UOfSfiEcPeoAfPollution Prevention and Toxics 4W0a1shMingSttroene,t,DSCW20460 ix0 ~ "i SZoao> 0 CERTIFIED MAIL PTeSrCflAuo8r(oEo)ctSaUnBesSuTlfAoNnaTmIiAdoLERtIhaSnKolNOTICE ON: N-Methyl Dear Sir: 3M is reporting information that shows N-Methyl Perfluorooctanesulfonamido stfourxboimmciitCttyoevidsantcoocneEsiPLsaAtbeo[nrstaewetio8tr(hye)tohdnaot2cokf1er3tes-laW#te3ee7dk3pDaeinrefdtla3ur7oy4r]oS.otcutEdanyncyol!fossNue-ldMfeoisntaththyeelsfpinraelviroeupsorlty dPoesrfellueovreolosc(t3a0ncasnudlf1o0n0ampipdmoNE-thMaenoFlO(SNE-iMnefFoOoSd)E)priondRuactes.d liAvsereexfpfeeccttes.d,Thhiegher liver changes included increased liver weights, hepatocyte hypertrophy, and fheopuantdocienltlhuelahrigvahcduoolsaeti(o1n0.0pLpomw)erancdhomliesdtderoosle a(n3d0ptrpimg)lyacneirmiadless.levNeelisthweerrelivaelrso eafnfiemcatlss.nor cholesteroltriglyceride changes were found in the low dose (3ppm) bSieggniinfniicnagntaltywreeedukc4edanbdodcyonwteiinguhitnsg wunetriel tprheeseenntdoifntthhee hsitugdhy.dosSeiganniifimcaalnstly croendtuicneudebdoudnytilwetihgehetnsdoocfctuhreresdtuidny.theWmeiedkldyosbeoadnyimwaelisghbtesgoifntnhineglaotwwdeoeske7 and Nanoinmeaolfstdhuerilnogwthdeosseecwoenedklhyaboofldtyhfweeisgthudtys wweerree ssiogmneifwihcaanttllyesdsitffhearnenctonftrroolms. tcohnrtoruolgsh. 14H)oowfevteher,lotwhedoovseeraalnlibmaoldsywwaesigshitgngiafiincadnutlryinlgestshethsatnudtyhe(cwoenetkrosls1. = = 5 S3e7 x 8=3 R E " FY1-80-201378 85000000031 060001 PDaogceumTewnot Processing Center (7407) July 24,2000 a`dTvheerCsoe-veafnfcecetrleepvoerlt (coNnOcAlEudLe)s atshatthtehmei3noprmboddoysewewiagshttheefnfeoc-tobfsocurnvdabatle3p--pm iwtawsansontoctorcroenlsaitdeedrweidtthoabneybciloilnoigciaclalclhyemaidsvterryseo.r anatomic pathological changes; "The study report is attached. Please contact Dr. William Weppner, 651-733-6374, for further information. Sincerely, e MN VCircaeneP.sre)Ksiodent, Specialty Materials Markets EI.ncl4o-suWreeesk: Range-Finding Dietary Toxicity Study with N-Methyl 2. P1e3r-fWleueorkooDciettaanreysuSltfuodnyamwiidtoh ENt-hMaentohly(lNP-eMrefFluOoSrEo)ocitnanReastusl(fTo-na6m3i1d4o) Ethanol (N-MeFOSE) in Rats (T-6314) 000002