Document LJ4v8pGqx1vb1MvLa3yx2VZzw
Fr AR226-3267
~~
`DuPonstodHaEsvkeilrloLnambeonrattaorSyeefnorceHesalth
AR226-3267
March 6, 2003
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To sxrsufmagrocie nases FROM. 1.C.Muska
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Medical Resere rec Number: [mm]
HHaasskkeellllSRaemfperleencNeumSbteanrdsard Number
22554025
AAnnaallyyttiiccaallRTeepsotrCtodNeo:raber
CuHA20y03.032
Notebook References:
[mm]
FApotertrafccothrvemdedpius1rtphosseaesn.aylytpircoatlocroelposretqfuoiretmheensttsudfyodoesnttisfuibsdtaabnocvees,abTlhiityabnaultymsiasywaalssobe" used
.
garsCACS
at 9
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NG
F p25
MeHadsikcealll SReasmepalrecNhuPmrbojeerc:t Number: `Amalytical Report Number:
f2a54m25] HA2003032
A sampleof H-25425 was submited on February 26, 2003apd ansiyzedgg February 27, 205.
ntageofactive ingredient (a.i.) was measured to
ith a ange of
3d
f nominal for replicate analyses (n = 3). The sponsor reported a purity of
hen
`the sample was submitted.
--~
ACKOWLEGEMENTS
Sample preparation by Sheil A. Riley (Chemistry Associate). Sample aalyss by Bogdan
Szostek (Senior Research Chemist).
SIGNATURE
Reporty: (pa`sSotneet CC. WMaasstatnkianta) 6-DaHtier- 2002 Analytical SiaffChemist
Date Issued:
t= How - avo
~
Coma Sanit
"of emf TSCA cer
HA-2003-032 page 2012
~
METHODS
cAhnraloymsaitsogfrorapthhye p(eHrPcLenCt)ovfiatih.ainGealsPaemrpmleeaotfioHn-2C5o4l2u5mnwa(sGPbCy)hiagnhd-rpeefrrfaocrtimvaenciendleixqudiedtector asucbcsotradnicneg taondthtehefoalnlaloywtiincgalmestthaondd.ardSosntioccaktsioolnutwiaosn.used to completely dissolve the test
SAMPLE PREPARATION & ANALYSIS
(A1l0iqmuLot)st(o0.g0i4v0e3n,o0m.i0n4a1l7caonndce0n.t0r4at0i9ognsraomfs4)0o3f0,H-4215704,25anwder4e09di0spspolmv,edreisnpetcettirvaehlyyd.rofuran
CHROMATOGRAPHIC CONDITIONS
ICnoslturmunme:nt:
HSteywrlaegtetl-PHacRka4r;d7M.o8dmeulm 1x130000HmPmLC(GPC column)
FMolboiwlReatPeh:ase
11000m%Litemtirnahydrofuran (THF)
Injection Volume: Column Temperature:
~~
3s5ouCl
Detection:
Refractive Index
CALIBRATION & QUANTITATION
~
Astasnedpaarrdat(e9s3a.m1p7l%epoufreH)-.25A42st5octekstsosluubtsitoannocfe Hw-a2s5d4e2s5iginnatteetdraahsytdhreofaunraalnytwicaasl urseefedrteonce
mHaPkLeC/cGalPiCb/raRtIioannsaollyustiisoonfsetahcathbcraalcikbertateidotnhestoelusttiosnolwuetiroensu.sePdetaokchoenisgthrtusctfarocmalriebprliactaitoen:
dcuertveermbiyneldeabsyt-aspqpualryeisngrergersepsescitoinv.e pMeeaaksuhreeigdhctosntcoentthreactailoinbsraftoironcaccuhrvtee.st solution were
mr RESULTS
H:25425 elutedfromthe HPLCcolumnas resolvedpagk wit retention tneofabout
`TablI.e The percent ofa.Inthe H-2p5p4m225542sample5 analyzed FPeberurarcyent 27,2003.
Alig
Nominal Measwed Nominal
21
"am0 0 mo 9029s
3
090 mo 924
[[Satvaenrdaagred%DeNvioamtiinoanl
09290
[Coetficeot of Variation
1%
--~ CompanySenizad,Does notcontain TSCAGSI