Document LBd9wQbZ9p9y4DZ2kYN2xed

3M FLUOROCHEMICAL SUBMISSIONS February, 2002 - May, 2004 INDEX OF 3M'S 2002-2004 AR-226 DOCKET SUBMISSIONS BY DATE Back to Menu May 2004 Click on Study Title to View Report May 11, 2004 May 11, 2004 Submission Cover Letter Page 1, 2, 3, 4, 5 Final Report, Descriptive Analysis of Serum Perfluorooctanoate (PFOA) and Perfluorooctanesulfonate (PFOS) Concentrations of Antwerp Employee Participants from the 2003 Fluorochemical Medical Surveillance Program, 3M Medical Department, August 14, 2003. Sample Analysis Report for Protocol EPI-0012, Quantitative Determination of PFOS and Related Compounds in Human Serum by LC/MS/MS, Northwest Bioanalytical Study No. NWBS00-091, November 21, 2001. Sample Analysis Report for Protocol EPI-PEuro, Quantitative Determination of PFOS, PFOSA, PFOSAA, PFHS, POAA, M556 and M570 in Human Serum by LC/MS/MS, Northwest Bioanalytical Study No. NWBS99-117, December 9, 1999. Sample Analysis Report for Protocol EPI-Swed, Quantitative Determination of PFOS, PFOSA, PFOSAA, PFHS, POAA, M556 and M570 in Human Serum by LC/MS/MS, Northwest Bioanalytical Study No. NWBS99-116, December 9, 1999. Final Report, Xenochemical Receptor trans-Activation by Perfluorooctane-based Chemicals, Boston University Department of Biology, 3M Reference No. T-6295.35, September 12, 2001. Final Report, An Investigation of the Mechanism of Toxicity in Adult Rats Exposed to High Levels of Perfluorooctanesulfonate (PFOS), 3M Project No. T-6295.31, April 23, 2004. Final Report, Analysis of Liver Enzymes, Glycogen, and Perfluorooctane Sulfonate (PFOS) Concentration in Samples from T-6295.25: One-Generation Reproduction Study of PFOS - Mevalonic Acid/Cholesterol Challenge and NOEL Investigation in Rats, 3M Project No. T-6295.28, April 23, 2004. Letter Report, Determination of Possible Interference of Perfluorooctane Sulfonic Acid Potassium Salt with Assay for Rat Cholesterol, 3M Project No. 6329.263, August 17, 1999. "Genotoxicity, Carcinogenicity, Developmental Effects and Reproductive Effects of Perfluorooctanoate: A Perspective from Available Animal and Human Studies," Association of Plastics Manufacturers of Europe and The Society of the Plastics Industry, December 12, 2002. Final Report, Acute Inhalation Toxicokinetic Study of Perfluorooctanesulfonyl Fluoride (POSF), 3M Study No. T7098.4, November 9, 2001. Final Report, Oral Toxicity Rangefinder for Perfluorooctane Sulfonyl Fluoride (POSF) in Rats, 3M Study No. T-7098.2, May 11, 2001. Final Report, Oral (Gavage) Combined Repeated Dose Toxicity Study of T-7706 with the Reproduction/ Developmental Toxicity Screening Test, Argus Research Protocol No. 418-028, 3M Reference No. T-7706, July 31, 2003. INDEX OF 3M'S 2002-2004 AR-226 DOCKET SUBMISSIONS BY DATE Back to Menu May 2004 Click on Study Title to View Report May 11, 2004 cont. Page 1, 2, 3, 4, 5 Final Report, Comparative Molecular Biology of Perfluorooctanesulfonamide (FOSA, T-7132) in Rats Following Four Consecutive Days of Dosing, Study No. DT15, 3M Reference No. T-7132, February 18, 2004. Revised Tennessee River Study a. Revised Report, (2002 Sampling Event) A Survey of Selected Fluorochemicals in the Decatur Alabama Area - 2002 Sampling, Entrix, Inc. Project No. 178401, November 2003. b. Revised Analytical Laboratory Report, Tennessee River Valley Samples, 3M Environmental Laboratory Study # E02-0443, September 12, 2003. Avian Studies a. Mallard Duck Acute Study i. Toxicological Summary, PFOS - Dietary Acute Mallard Study, March 23, 2004. ii. Final Report, PFOS: A Dietary LC50 Study with the Mallard, March 23, 2004. iii. Analytical Report, Laboratory Report Revision 1: Analytical Report of Data for PFOS Dietary LC50 Study with Mallards (Sera and Liver), March 19, 2001. b. Mallard Duck Pilot Study i. Toxicological Summary, PFOS - Dietary Chronic Pilot Reproductive Study: Mallard, May 5, 2004. ii. Final Report, PFOS: A Pilot Reproduction Study with the Mallard, March 24, 2004. iii. Analytical Report, Extraction of Potassium Perfluorooctanesulfonate from Mallard Serum and Mallard Liver for Analysis Using HPLC-Electrospray/Mass Spectrometry (Mallard Pilot Study Samples), Centre Study No. 023-042, September 10, 2001. iv. Analytical Report, Extraction of Potassium Perfluorooctanesulfonate from Egg Membrane, Albumen, and Yolk for Analysis Using HPLC-Electrospray/Mass Spectrometry (Quail and Mallard Pilot Studies samples), Centre Study No. 023-063, September 10, 2001. c. Mallard Duck Definitive Study i. Toxicological Summary, PFOS - Dietary Chronic Definitive Reproductive Study: Mallard, May 5, 2004. ii. Final Report, PFOS: A Reproduction Study with the Mallard, March 24, 2004. INDEX OF 3M'S 2002-2004 AR-226 DOCKET SUBMISSIONS BY DATE Back to Menu May 2004 Click on Study Title to View Report May 11, 2004 cont. Page 1, 2, 3, 4, 5 Avian Studies cont. c. Mallard Duck Definitive Study cont. iii. Analytical Report, Analytical Phase Report for PFOS: A Reproduction Study with the Mallard (Mallard Definitive Study Sera and Liver Analyses), 3M Environmental Laboratory Study # E01-1256, January 22, 2003. iv. Analytical Report, Extraction of Potassium Perfluorooctanesulfonate from Red Blood Cells and Serum for Analysis Using HPLC-Electrospray/Mass Spectrometry (Samples from Definitive Mallard and Quail Reproduction Studies), Exygen Study No. 023-070, June 12, 2003. v. Analytical Report, Analysis of Perfluorooctanesulfonate in Mallard and Quail Egg Yolk (Mallard and Quail Definitive Reproduction Study Eggs), Exygen Study No. 023-070, July 5, 2002. d. Northern Bobwhite Quail Acute Study i. Toxicological Summary, PFOS - Dietary Acute Northern Bobwhite Study, May 5, 2004. ii. Final Report, PFOS: A Dietary LC50 Study with the Northern Bobwhite, Wildlife International, Ltd. Project No. 454-103, March 24, 2004. iii. Analytical Report, Laboratory Report Revision 1: Analytical Report of Data for PFOS Dietary LC50 Study in Northern Bobwhite (Sera and Liver), 3M Environmental Laboratory No. FACTTOX-129, March 23, 2001. e. Northern Bobwhite Quail Pilot Study i. Toxicological Summary, PFOS - Dietary Chronic Pilot Reproductive Study: Northern Bobwhite, May 5, 2004. ii. Final Report, PFOS: A Pilot Reproduction Study with the Northern Bobwhite, Wildlife International, Ltd. Project No. 454-104, March 24, 2004. iii. Analytical Report, Extraction of Potassium Perfluorooctanesulfonate from Quail Serum and Quail Liver for Analysis Using HPLC-Electrospray/Mass Spectrometry (Quail Pilot Study Samples), Centre Study No. 023-041, September 10, 2001. INDEX OF 3M'S 2002-2004 AR-226 DOCKET SUBMISSIONS BY DATE Back to Menu May 2004 Click on Study Title to View Report May 11, 2004 cont. Page 1, 2, 3, 4, 5 Avian Studies cont. f. Northern Bobwhite Quail Definitive Study i. Toxicological Summary, PFOS - Dietary Chronic Definitive Reproductive Study: Northern Bobwhite, May 5, 2004. ii. Final Report, PFOS: A Reproduction Study with the Northern Bobwhite, Wildlife International, Ltd. Project No. 454-108, March 24, 2004. iii. Analytical Report, Analytical Phase Report for PFOS: A Reproduction Study with the Northern Bobwhite (Quail Definitive Study Sera and Liver Analyses), 3M Environmental Laboratory Study #E01-1245, April 18, 2003. Bluegill Study a. Robust Summary, Acute Toxicity to Bluegill Sunfish, 3M, April 14, 2004. b. Analytical Report, 96-Hour Static Bluegill Toxicity Test: Aquatic Toxicity Data Sheet (FC-95), 3M, May 27, 1978. Summary Table, PFOS Ecotoxicological Testing Results Comparison of Effect Concentrations Calculated Using Different Sample Purity, 3M, May 2004. Addenda to Previously Submitted Reports Revised to Reflect the Most Recent PFOS Purity Analyses Letter to Susan Beach from Kurt R. Drottar, Wildlife International, Ltd., September 27, 2001, enclosing: a. Addendum, PFOS: A 96-Hour Static Acute Toxicity Test with the Saltwater Mysid (Mysidopsis bahia), Wildlife International, Ltd. Project No. 454A-101, September 27, 2000 [Addendum to AR226-0095]. b. Addendum, PFOS: A 96-Hour Static Acute Toxicity Test with the Fathead Minnow (Pimephales promelas), Wildlife International, Ltd. Project No. 454A-102, September 27, 2000 [Addendum to AR226-0083]. c. Addendum, PFOS: A 96-Hour Toxicity Test with the Freshwater Alga (Selenastrum capricornutum), Wildlife International, Ltd. Project No. 454A-103A, September 27, 2000 [Addendum to AR226-0085]. d. Addendum, PFOS: A 48-Hour Static Acute Toxicity Test with the Cladoceran (Daphnia magna), Wildlife International, Ltd. Project No. 454A-104, September 27, 2000 [Addendum to AR226-0087]. e. Addendum, PFOS: A 96-Hour Static Acute Toxicity Test with the Freshwater Mussel (Unio complamatus), Wildlife International, Ltd. Project No. 454A-105, September 27, 2000 [Addendum to AR226-0091]. INDEX OF 3M'S 2002-2004 AR-226 DOCKET SUBMISSIONS BY DATE Back to Menu May 2004 Click on Study Title to View Report May 11, 2004 cont. Page 1, 2, 3, 4, 5 f. Addendum, PFOS: A 96-Hour Shell Deposition Test with the Eastern Oyster (Crassostrea virginica), Wildlife International, Ltd. Project No. 454A-106, September 27, 2000 [Addendum to AR226-0089]. g. Addendum, PFOS, A Flow-Through Life-Cycle Toxicity Test with the Saltwater Mysid (Mysidopsis bahia), Wildlife International, Ltd. Project No. 454A-107, September 27, 2000 [Addendum to AR226-0101]. h. Addendum, PFOS: An Early Life-Stage Toxicity Test with the Fathead Minnow (Pimephales promelas), Wildlife International, Ltd. Project No. 454A-108, September 27, 2000 [Addendum to AR226-0097]. i. Addendum, PFOS: A Semi-Static Life-Cycle Toxicity Test with the Cladoceran (Daphnia magna), Wildlife International, Ltd. Project No. 454A-109, September 27, 2000 [Addendum to AR226-0099]. Letter to Susan Beach from Raymond L. Van Hoven, Wildlife International, Ltd., November 27, 2000, enclosing: a. Addendum, Non-GLP Study: Determination of the Solubility of PFOS in Wildlife International, Ltd. Freshwater, Freshwater Algal Medium, and Saltwater, Wildlife International, Ltd. Project No. 454C-101-1, November 27, 2000 [Not previously submitted to the AR226 docket]. b. Addendum, Determination of the Water Solubility of PFOS by the Shake Flask Method, Wildlife International, Ltd. Project No. 454C-107, November 27, 2000 [Addendum to AR226-0052]. Letter to Susan Beach from Edward C. Schaefer, Wildlife International, Ltd., December 1, 2000, enclosing: a. Addendum, PFOS: An Activated Sludge, Respiration Inhibition Test, Wildlife International, Ltd. Project No. 454E-101, December 1, 2000 [Addendum to AR226-0093].