Document KzE6MzyerZ9dk836Va8vDrzbo

PLAINTIFF'S EXHIBIT UC-3568 1009 Letters silica. Smith i personal communica tion) used chrysotile from Arizona prepared by the Badollet and Gantt TlWSH^^^Wegnanc^^Therapeutic abortion is the only means present ly available to prevent the birth of method to produce mesotheliomas abnormal infants, and this is not in hamsters. legally condoned in most states. We obtained similar results with One of the major problems in pure chrysotile in mice.1 These establishing laws regarding abortion .Smoking ;uid the Coitm.il v Arteries findings indicate that asbestos in its various forms can cause meso thelioma in both animals and man. in instances where the infant may be born abnormal is determining the risk of abnormality. A numlier 7\> the Editor: -- Dr. Seltzer's The letter also States Wagner's1 of studies have 'teen reported in thoughtful and well-documented re- > findings that the "time lag between J which the risk of congenital abnor view of "Smoking and Coronary I last exposure and tumor formation | malities of infants bom to women Heart Disease" (203:193, 19681 was always long, averaging 40 to with clinical rubella in the first tri rmkes no reference (o personality [ 50 years." However, Kleinfeid5 et al j mester varies considerably, largely fat tors, Perhaps there are no re- j reported the average years from I depending on whether the study -earch data about personality dif- j onset of exposure to death was 29.5 1 was conducted during epidemic or ferenees of the cigarette smoker in years with a range of 15 to 40 j nonepidemic years. Since etiologic contrast to the pipe or cigar smoker, years. Our patient, a chrysotile agents other than rubella can pro but popular attitudes generally sug worker, died 23 years after the first duce illnesses resembling rubella, gest that the pipe or cigar smoker is more phlegmatic and less likely to suffer from tension states. A three-year exposure. Another 'pa tient we have seen died of meso thelioma after 15 years of contin it is likely that the risk figures re ported in the past for congenital rubella are low. Current reports striking difference in the incidence uous exposure. We have also seen emphasize that the etiologic role of of coronary disease is found be tween the two groups. Apparently the Surgeon General's Advisory a young man who died of acute pulmonary edema after a short pe riod of work which entailed blow in utero rubella infections in cataracts (203:632, 1968) and deaf ness1 is greater than previously rec Committee on Smoking and Health iquoted by Dr. Seltzer) in its list of predisposing factors mentioned only "occupations involving--stress" and ignored individual personality factors basic to psychomatic dis ing asbestos insulating material into house walls without wearing a mask. We think that inhalation of as bestos fibers in any of its various forms--crocidolite, chrysotile, amo ognized. In a study described re cently in The Journal (203.-627, 1968), we have attempted to es tablish the risk of fetal infection by the use of new laboratory proce dures. Twelve women with clinical turbances, which may predispose site, or tremolite--carries a certain rubella in the-first trimester of preg to coronary heart disease. Bvnatn S. Lacy. J*., MT> M*nhaltnn, Kin risk and should be avoided. Melvin C. Goowjn, MD George Jagatic. MO Ill nancy were studied and were proven by laboratory means to have been infected with the virus. Therapeutic abortion was performed in ten in Asbestos and Mesothelioma 1. Owen, G.W.: Turnon And Ex posure to Axbevton Dufit, Ann NY Acnd Set 132: *74-684. 1965. stances, and nine of the ten fetuses were found to be infected with the To the Editor:--A recent letter (203:1142, 1968) states that the 2. Winner, J. C , end Skidmore, J.W.; A*- beslcm Dust Deposition and Retention in Rets. Ann NY Acad Sci IttiTT-86. 1<*S. virus. Two women elected not to have their pregnancies interrupted. problem of mesothelioma formation 4. Jugal*?. J., et *1: Tissue Response fa> Intra* Both of these women delivered in is "not one that involves the whole peritoneal Axbeatos With Preliminary Report of Acute Tonicity ofAffl*tftos in Mice. Euvtmn Re* fants which appeared normal at asbestos industry, but only users to be published* birth. Since the time the paper was of crocidolite, and this mineral rep resents a relatively small proportion 4. Wagner, J.C.: Proceedings of the Pneu/noconinria Conference. Johonneaburg. A. J. Arenslein led.) f^ondon: J. & A. Churchill, Ltd.. written, six months have elapsed, and during this interval both infante of total consumption. It has been shown' that mesothelioma occurs in ]<!. 5 Kleinfeid, M.; Me*ite, J.; and Koojmen. O-: Mortality Experience in a Group of Asbeetoa have developed stigmata of intra uterine rubella infection. In addi workers exposed to chrysotile ex Workeis, Arch Environ Health 15:117-180 I Aug) tion, another woman who experi tensively mined in Canada. We I9S7. enced rubella in the first trimester have seen mesothelioma formation in workers weaving brake lining, Intrauterine Rubella has come under our observation; upon termination of the pregnancy, which is made from chrysotile. Ex Transmission the fetus from this woman was in posure was three years as a young fected with the virus. Thus, in lab- adult, and death was caused by a To the Editor:--Tha. recent articles oratory-proven maternal rubella, peritoneal mesothelioma at 43. An by E. B. Buynak et al (204:195, the incidence of fetal infection ex other case was a 50-year-old man 1968) and others'-' demonstrating I ceeds 92% (12 of 13 cases studied), who worked in a Canadian asbestos the feasibility of attenuating rubel- I and malformations occur in a high mine five years and who died of la virus in a manner acceptable for I percent of the fetuses infected in pleural mesothelioma 15 years after vaccine use provides great expecta- ! the first trimester. the first exposure. Analysis of tissue tion that this disease will soon be j Although abortion for rubella is by x-ray diffraction indicated that controlled. Unfortunately, during ! not legal in most states, it is quite chrysptile was the only form of as the time required to produce suffi obvious that it is being performed bestos present. Wagner and Skid cient immunity in the population, widely. Siegel et al' in a seven year more' induced mesotheliomas in many women and their physicians prospective study of maternal ru the pleura of rats that inhaled will be faced with the problem of bella in New York City reported chrysotile, crocidoiite, amosite, and rubella occurring in the first tri- 331 therapeutic abortions in 763 'AMA, June 10, 1968 o Vol 204, No 11 A 17 94b UCC 007831 151