Document KoGdKmqY80n32XDvnp1GEEZK

EXPERIMENTAL RESEARCH PlUL Gkojj. M.D. Director. !HF Research Laboratories This research is now conducted chiefly in the Industrial Hygiene Research Unit of the De partment of Occupational Health, Graduate School of Publfc Health, University of Pitts burgh; Department of Pathology of the Medical University of South Carolina; and Mellon Institute of Camegie-Mellon L Di versity. ALUMINUM As the scientific literature contains mnflich information on the ability of various tvpes .liiurunum powders of respirable size to prcdu i.uimonary fibrosis, in 196o. experimental anim; rats, hamsters and guinea pigs) were exposed British and United States produced metallic powd via intratracheal injections and inhalation excosn chambers. The first research phase of this IHF :r !_ect was completed during 1970. -Animals not -ac: need at earlier stages were allowed to live out A maionty of their life span, i. e., about two vears report of research findings, now in preparation f publication, sheds some light on the chief areas apparent conflict resulting from studies in tru laboratories. Certain hypotheses, based on results IHF's findings to date should be subjected to furth< experimental proof, therefore, our publication presents a preliminary report of progress Soonsor Aluminum Company of America. Reynolds Meta Company.-Ailberline Manufacturing Company. Inc U S. Bronze Powders. Inc. and Valley Metallurgy. Processing Company. Inc.) FIBROUS DUSTS When fibrous dusts are injected intratracheal!polvpoid inflammatory lesions develop within :'ol days in smaller bronchi and bronchioles. These ter. to heal and disappear in time. These lesions are art factual in the sense that they are not found i animals inhaling the same dusts. It is therefor reasonable to attribute the proliferative pmvpoi lesions to the particular technique by which th dusts have been introduced into the lungs. This wor has been published: "The Pulmonary Response t Fibrous Dusts of Diverse Compositions." Paul Gro; et al. Am. Ind. Hvg. Assn. J. 31:125-132 (March April) 1970. The method of quantitating the fibrous dust ac ferruginous bodies in lungs of Pittsburghers and :h results obtained was reported at the Third Intern; tional Symposium on Inhaled Particles (Londot September 16-23, 1970) and will be published in th proceedings of this meeting. (Sponsors: Johns-Mar ville Corporation; PPG Industries; Pittsburgh Corr ing Corporation; Raybestos-Manhattan. Inc.; U. Public Health Service.) ASBESTOS Because of an epizooty which decimated the ra and hamsters injected intratracheally with asbestc dust (chrysotile, amosite, and crocidolite) treated i variousf=ways to render the dust metal-free. ne> animals have been injected with these material These new animals are now under observation. Sine the purpose of this study is to determine the locus c pathogenicity of asbestos dust -- particularly th carcinogenicity--the animals will be allowed to li-. out their lives!(Sponsor: U.S. Public Health Service 3 01 13 3 O 9 - 4f . 'j