Document KVxnYvkgMYKMynvZpDv7KNGw

CHEMICAL MANUFACTURERS ASSOCIATION January 5, 1980 UGL16104 TO: Vinyl Chloride Project Panel Vinyl Chloride Research Coordinators SUBJECT: Symposium on Vinyl Chloride Monomer/Polyvinyl Chloride to be Sponsored by OSHA, NIOSH, and NIEHS "sometime during the latter part of February, 1980" Gentlemen: Supplementary to the information on the Subject Symposium included under Section 10.0, Record of Research Coordinators Meeting, November 28, 1979 is the following additional information about this nebulous symposium; 1.0 Although "scheduled" for the "latter part of February, 1980" no firm dates have been set nor are there any written documents or announcements pertinent to the symposium. 2.0 Dr. Infante, in response to my direct questions responded as follows: 2.1 The theme of the symposium is: "Reevaluation of the Toxicity of VCM and PVC and Structural Analogues". 2.2 The sponsors are OSHA, NIOSH, and NIEHS. 2.3 The nature of the papers desired are: 2.3.1 "Experimental bioassay work on VCM and PVC" 2.3.2 "Epidemiological study(s)." Dr. Infante seemed especially anxious to have someone present a paper covering the EEH studies sponsored by the Vinyl Chloride Panel. 2.3.3 "Give us some kind of generic assessment of PVC dust in various industries handling and processing VCM and PVC". Formerly Manufacturing Chemists Association--Serving the Chemical Industry Since 1872. 1825 Connecticut Avenue. NW Washington. DC 20009 Telephone 202/328-4200 Telex 89617 (CMAWSHi 2 * s 2.3.4 "Industrial hygiene measurements of PVC-air measurements" 3.0 During a lengthy discussion with Dr. Infante, who is apparently the prime mover in putting together the symposium, I pointed out the unduly restrictive time frame during which papers are supposed to be written. He failed completely to respond appropriately to this critical point. Dr. Infante concluded the conversation with the comment that participation of members of the Vinyl Chloride Project Panel and CMA will be welcomed. To this comment, I made no commitment whatever other than to say that the symposium and all of the information he gave me would be brought to the attention of Panel members as promptly as possible. Dr. Torkelson plans to discuss the symposium with appropriate members of SPI. Should any of you plan to present papers, I suggest you contact Ted immediately and keep the Project Administrator informed of your plans. Sincerely, JTS:das J. T. Seawell Project Administrator Vinyl Chloride URL 16105 cit^JU CMwN' fcju CHEMICAL MANUFACTURERS ASSOCIATION January 5, 1980 JAN 9 1980 TO: Vinyl Chloride Project Panel Vinyl Chloride Research Coordinators MEDICAL DEPARTMENT SUBJECT: An Epidemiological Study of Respiratory Disease in Workers Exposed to Polyvinyl Chloride Dust, A Study Completed by the Institute of Occupational Medicine, Edinburghf Scotland under Contract with Imperial Chemical industries Limited. Gentlemen: Attached is a final summary statement on the subject document drafted originally by Mr. R. N. Wheeler, approved by the counsels for both CMA and ICI, and checked for technical accuracy after editing and/or modifying by counsel. During the meeting of the Research Coordinators on November 28, 1979, it was agreed that the subject document in final form would be sent to all members of the Vinyl Chloride Project Panel and to the Research Coordinators. Sincerely, JTS:das Enclosure J. T. Seawell Project Administrator Vinyl Chloride URL 16106 Formerly Manufacturing Chemists Association--Serving the Chemical Industry Since 1872. 1825 Connecticut Avenue. NW Washington. DC 20009 Telephone 202/328-4200 Telex 89617 (CMA WSH; December 20, 1979 TO: THE SOCIETY OF THE PLASTICS INDUSTRY VINYL CHLORIDE SAFETY GROUP CHEMICAL MANUFACTURERS ASSOCIATION VINYL CHLORIDE TASK GROUP RE: AN EPIDEMIOLOGICAL STUDY OF RESPIRATORY DISEASE IN WORKERS EXPOSED TO POLYVINYL CHLORIDE DUST In view of a number of published reports regarding abnormal lung function, pneumoconiosis and other respiratory symptoms allegedly resulting from exposure to PVC dust, in early 1979 Imperial Chemical Industries Ltd. (ICI) commissioned a study to determine whether PVC dust caused any measurable effects on the lungs of workers exposed to it. The study was carried out by the Institute of Occupational Medicine, an independent research organization based in Edinburgh, Scotland. Copies of the report covering the findings of this study dated October 1979 were delivered to the Chemical Manufacturers Association and the Society of the Plastics Industry in late November. Review of this report indicates that the respiratory symptoms, pulmonary functions, and a representative sample of X-rays of 818 workers were com pared with estimates of the amount of fine PVC dust to which each worker had been exposed. As with any study of this type and scope the results yield more questions than they answer and we have been advised that ICI plans to continue this investigation. Of particular significance in the October report are the following study conclusions and observations: 1. Respiratory Symptoms Exposure to PVC dust was not associated with chronic cough or sputum production, acute chest illnesses, acute bronchitis, pneumonia, pleurisy or asthma. It was also found that workers who smoked cigarettes and had also been exposed to higher amounts of PVC dust reported slight shortness of breath on exertion more often than smokers who had been exposed to lower amounts of dust. URL 16107 2- - 2. Lung Function There was a small but significant reduction in lung ventilation capacity (forced expired volume, FEV^) among men with higher PVC dust exposure. This effect was seen principally in current smokers and was not confirmed in non-smokers. The reduction noted was about one-seventh that caused by aging and about equal to the loss expected with a one pack a day cigarette smoker. It was also found that the forced vital capacity (FVC) was reduced to a statistically significant degree at higher PVC dust ex posures but to a lower magnitude than that of the FEVl. 3. Chest X-Rays There was no evidence of serious progressive pulmonary fibrosis (pneumoconiosis). However, certain abnormalties similar to what might be expected from aging or smoking appeared on the lung X-rays of a small percentage of workers exposed to higher levels of dust. 4. Lung Cancer No excess of lung cancer was found in the study population. 5. Miscellaneous The observed effects could not be related to past exposure to vinyl chloride monomer. While dispersion or emulsion PVC processes produce more dusts in in the respirable range it was not possible to clearly separate one process from another in the study. To summarize the results noted previously, the study indicates an adverse pulmonary effect is caused or accelerated by PVC dust inhalation particularly among smokers. On the positive side, the study shows many possible health effects are not related to PVC dust exposure. The study reinforces recommendations for the use of controls to protect employees from excessive exposure to any respirable dust. Imperical Chemical Industries Ltd. should be commended for an excellent study. They have promised to keep industry, government and labor aware of results in their continuing studies. URL 16108