Document KVk7zN1maQazbB2kmvmNbz20

Attachments to Letter to C. Auer dated May 4, 2000 Perfluoroctane Sulfonate Studies Human Sera/Medical Surveillance/Epidemiology Memorandum from D.E. Roach and S.D. Sorenson, 1983 Decatur Blood Fluoride Review, January 20, 1984 Antwerp Blood Testing Results from June 1995, by Jeffrey H. Mandel, M.D., and Jean Burris, R.N., O.H.N., November 6, 1995 Analysis of Serum Values in Decatur Workers, prepared by Michel Burlew for Larry Zobel, M.D. and Jeffrey Mandel, M.D., April 2, 1998 Laboratory Report, Analysis of FCs in Samples of Children's Sera, Laboratory Report 9 No. FACT-GEN-011, 3M Environmental Laboratory, May 21, 1999 S) Laboratory Composite Report, Analytical Reports of Data for Fluorochemical Analysis / in Human Sera, LIMS No. 1623, 3M Environmental Laboratory, April 28, 2000 c*> b. x~ a i m * - 223-68-0 L C. m. tat! - 223-68-0 0 . r ^ n - R a d ic a l - Dft ecatu r fs-j C. C. Java - 223-68-0 B. A. U h | * - 223-58-0 V.B Pearleos - 223-68-0 re : T. B . O rlfT lth - 220-21-02 V. C. MeCoralCk - 22O-2S-02 1 . K. 8ugg - 220-2B-02 F . A. U b al, M.D. - 220-21-02 BEST COPY AVAILABLE -fa J . B . ' M K - CBBQCAL 8FECIAJ3T I0TXSZ0R - DECATUR ftvrt D. X. MACH - MEDICAL, KSZCAL 8 9 TICES - 220-28-02 8 . D. 80HDC80S - KZDZCAL, IBS. HTO. SERT. - 220-21-02 SLfaaet 1963 D ecatu r Blood F lu o r id e A erie* Om Ja n u a ry 2 0 , 196 A l a is to summarise th e _ re su lta o f th e 1983 o rg a n ic flu o rin e - In blood a p n lto rln g eooduetSS- aa p a r t o f th e c o n tin u in g flo o ro cb taleal study iragraa- The co n centration of organic flu o rin e in a p erso n 'a blood is b e lie re d a function of tb e aagnltude o f past and cu rren t exposures and tb e ra te o f e x c re tio n . M anlcoring o f tren d s o f organic f l u o r i n e c o n c e n tra tio n s In t b e b lo o d can p ro r id e In fo rm tIon on tb e mrfeent o f a tp o su re and e f f e c ti v e n e s s o f I n d u s t r i a l h y g ien e cootr o is . The r e s u l t s o f tb e blood m i t e r i n g f o r 196? and 1983 a r e com pared. Tbe r s u l t a a r e c a te g o riz e d by work a re a a c c o rd in g to l i s t s a a ta ltte d by Opal C a m b e ll. Tbe comparison Includes only th o s e em ployees who p a r t i c i p a t e d l a b o th 1982 and 1983. Those em ployees who p a r t i c i p a t e d In 1962 b u t not In 1963 a r e not in c lu d e d . S e v e ra l em ployees vbo p a r t i c i p a t e d In 1983 and In e a r l i e r y e a r s , b u t not la 1962, a r e coassen t ed cn s e p a r a t e l y . S ev e/al employees ere In d ica ted as having tra n s fe rre d to another departm ent sometime during tb e In terim o f th e t e s t s . T heir r e s u lts were compared la tb e o rig in a l departm ent to reduce c m p ie x ity . The ^ p a r e n t slo v e x c re tio n ra te Is b eliev ed to re d a c t p o ssib le b in s to a very low amount. T a b le I compares av e rag e OF c o n c e n tr a tio n s by 1962 and 1963. The t a b l a a l s o In c lu d e s tb e ra n g e o f OF c o n c e n tra tio n s found. Tbe ram alts Indicate a continuing dnravard trend In nearly a l l mmm J. t. - a - Ja n o a ry 2 0 . 196k Table I I la a depletion o f th e n a b o f decrease increases ad ' Of enBoen t i a t t o n s hot d id s o t c h e a t . I t should be a o tad t h a t th p re c is io n o f th a n a ly tic a l a c t hod la use in H a l t e d t o 1 1 pjan c t lo v e r blood l e v e l s ! a r t * r o s t e r a t h ig h e r b lb * _ _ l e v e l s . t h e r e f o r e , t h e s l t n l f l e s a o e o f 1 ppe change* may he H a lt e d . Both t o t a l c h a f e s aod change* g r e a te r th a a 1 ppa a r e d e p le te d . Za e i t h e r e a s e , t h e r e a r e a o re d ec rea se* t h a a laereasee. ta b le I I I B oaaarlzes th e nuhbar of copier* la eeeb area h r Of c o n c e n tra tio n . The number In clu d e a l l e m p ire * t e a t a d l a 1993. Supervisor free th e Indicated area* ere included in the to ta l* . I t can he sees th a t th e m ajo rity of eaplorees have Of e o o e e o tra tlo a s le s s th an 5 ppm. T ab le IT la e la d e * a d d itio n a l consenta cn r e s u lts not Included in t h e d a ta e o o p a rls o o s . The r e a u lt* ec o te d upon I n d i c a t e a doenward tr e a d . In e l u s i o n , a o a t a re a s have e tp erlen ce d a dovnvmrd tr e n d . In su ffic ie n t evidence e x ists to d etersin e th e ex cretio n ra te or e h e th e r a l l p e rso n a t e r e t e sfe th e sane r a t e . The d a ta la beU ev ed t o be i n d i c a t i n g t h a t Impro v ed ex p o su re c o n t r o l s a r e having a p o s itiv e e f f e c t. I t Is leccomended th a t are a s not e x h ib itin g a d eclin e be e sp e c ia lly reviewed for exposure p o te n tia l and f e a s ib le improved c o n tro l m easures. While a l l e tu d le e to d ate f a i l to d em o n strate human d le e a e e or p a tte r n * o f a d v e rs e e f f e c t associated v lth organic flu o rin e concentrations In th e blood. I t Is Im perative th a t ee continue every e ffo rt to reduoe exposure and Of lev els to the Invest degree possible. SBS/hZIt/er - 4 o A f v * * * - * 9^ * 004257 a. i . - - TABLE X B! >TCOPY AVAILABLE Organic F lu o rin e Blood C o n cen tratio n , FFH J u u u y 20 1' 1 j Bldg 2 T||| t ! O firatm ------ *SS*2L 1 12 Bldg 3 n a a t S o p irriM n O pcrauri 1 25 lld g 3 north S u p e rv iso rs O perators 4 21 Bldg 3 E ast S u p e rv iso rs O perators 3 24 Bldg 4 B erth S u p e rv iso rs O perators 3 34 Bldg * South S u p e rv iso rs O perators 3 25 M aintenance Shop A ll Bldgs Bldg 3 . Bldg 2 A A 1 14 S 4 B astavatar T tsstaia t B oiler house " 4 2 U b u in w y 19 P rocess B aglneertag " " 4 1W j -2 3.1 1903 2 3 .5 55 9.0 7.4 S .t 4.3 4.9 4.4 55 5.1 4.9 3 3.3 2.9 2.7 2.3 3 4.1 3.9 0 .9 1.0 4 . 2 .5 2 .0 2 .5 1.1 a ll 0 . 1 .4 5 .4 2.3 3 .3 <1 1 .2 41 1902 < 1-4 1 1903 2-4 2-23 2-15 4-7 2-12 3-4 2-12 4-4 1-12 1-15 1-4 --1-9 3-4 -1 1-4 2-3 -C 1-20 2-4 *. 1 -2 0 < 1-2 1-3 aC. 1-12 1-5 2-4 2-3 -C 1-3 <1 -C 1-2 C 1-5 3-11 < .1 -4 1-4 < 1-1 -C .l-4 -tl-1 'OffPW 4+ V-**** 004258 % J a a u u y 30, 1M4 TABU n U n t e r o f XncTMMa mnd D t e r i w i Oseros-- la c ro -- _ s . A He Chongo 1 6 1 A Nv o t e r o f Chongos Mors Thon 1 fTH Pocro lacro 1 10 1 1 73 AA 11 6 1 A2 21 88 32 26 AA -1 12 o 77 22 1 22 211 2 11 -- 004259 fr i 004260 .m 3* * . r - < Jnux]r 30, 1M4 BEST COPY AVAILABLE tin s n A dditional T sst B asalts B allila, 3 l u t 3 March 3 Zast 4 Rarth 4 Seath 2 piar* ^ lC t a s t a i IM I 1 i n d i a s i Crea 12 to 11, 1 fro n 14 te 7 1 p lo ra 1oL t a s t a i I M I d a d I n a i f r a a 10-11 1 ploraa lo a t ta s ta i IM O d a r lin a i fra 9-3 2 aapl*7*** l* * t t a s t a i IM I i a e l l s a i fra a 3 te 2 ai 5 te 3; 1 l t t a s t a i 1980 d aelinad fra a 8 to 6 2 a a p lo r a a s l a s t t a s t a i I M I d a c lla a d tram i 6 t e 3 a n i I s e r a a a a i f r a a 11 ce 1 **" 3 p l o 7M l o s t t a s t a i I M I ; 1 aheaad ae ch asg a, 2 i o c l l a a i 3 t e < 1 , 6 Ce 3 . 1 p lo r a a w ith or la v a i e f 20 orbai la B ldg. 3W u e t ll IM I 004261