Document KRzobK2aM7VmRJqr6ROvrJ8q0

H-24516: Subchronic'loxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations AR226-3201 DuPont-5368 TRADE SECRET Study Title H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Volume 5 of 5 Laboratory Project ID: DuPont-5386 TEST GUIDELINES; U.S. EPA Health Effects Test Guidelines OPPTS 870.3100 (1998) AUTHOR: Gregory S. Ladies, Ph.D., D.A.B.T. STUDY COMPLETED ON; December 3,2001 PERFORMING LABORATORY: E.L du Font de Nemours and Company Haskell Laboratory for Toxicology and Industrial Medicine Elkton Road, P.O. Box 50 Newark, Delaware 19714-0050 WORK REQUEST NUMBER: flBBi SERVICE CODE NUMBER: flHij SPONSOR STUDY NUMBER: flBHHBf Page 1281 of 1500 Company Sanffized. Does not contain TSCA CB! H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-5386 APPENDIX MM INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Pi ADULTS AND Fi ADULTS i '^OQ Company Saniteed. Does not contain TSCAGBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Pi ADULTS FINAL BODY AMD ABSOLUTE ORGAN WEIGHTS (grams) FROM MALE RATS GROUP: 1-0 ANIMAL NUMBER 0 nig/kg/day FINAL BODY THYROID GLAND 643148 643229 643218 643207 643280 643211 643197 643242 643251 643147 643276 643254 571.6 518.8 632.6 544.9 627.7 591.0 622.8 645.3 582.2 613.3 759.3 546.8 0.019 0.016 0.023 0.023 0.027 0.021 0.024 0.022 0.018 0.020 0.023 0.018 1283 Company Sao'feed. Does not eontatn T8CA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Pi ADULTS FINAL BODY AMD ABSOLUTE ORGAN WEIGHTS (grams) FROM MALE RATS GROUP: III-O ANIMAL NUMBER 25 mg/kg/day FINAL BODY THYROID GLAND 643287 643188 643230 643170 643144 643277 643214 643166 643153 643177 643291 643167 643223 643233 643183 643219 643263 500.5 688.9 544.3 619.2 519.8 680.8 622.6 615.7 589.9 593.7 635.8 617.1 534.2. 529.0 628.4 645.9 539.5 0.016 0.021 0.016 0.017 0 .018 0.029 0.018 0.020 0.013 0.016 0.017 0.023 0.023 0.020 0.020 0.026 0.019 1284 Company SanWzed. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - PI ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM MALE RATS GROUP: V-0 ANIMAL NUMBER 100 mg/kg/day FINAL BODY THYROID GLAND 643313 643146 643312 643199 643216 643245 643301 643200 643157 643238 643164 643154 643208 643190 549.8 624.4 554.9 564.1 555.0 501.8 604.8 616.4 603.9 535.4 639.8 460.3 425.2 564.9 0.026 0.028 0.012 0.022 0.023 0.018 0.018 0.024 0.030 0.027 0.019 0.020 0.018 0.023 1285 Company Sanitized. Does not contain TSCA CBI H-24516: Subchromc Toxicity 90-Day Gavage Study m Rats with One-Generation Reproductive Evaluations____________DuPont-5386 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Pi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM MALE RATS GROUP; VII-0 ANIMAL NUMBER 250 mg/kg/day FINAL BODY THYROID GLAND 643289 643171 643158 643249 643161 643248 643285 643274 643192 643222 643160 643191 643302 643317 456.0 628.2 639.7 583.9 587.8 407.7 498.3 527.3 613.3 542.6 509.0 541.5 547.9. 497.4 0.027 0.028 0.043 0.014 0.030 0.018 0.016 0.024 0.025 0.025 0.018 0.024 0.030 0.025 1286 ewnpany Sanitized. Does not contain TSGACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Pi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP: II-O ANIMAL NUMBER 0 mg/kg/day FINAL BODY THYROID GLAMD 643459 643480 643363 643421 643.419 643401 643455 643378 643447 643478 643386 377.8 330.8 379.1 286.3 402.9 324.0 331.8 376.7 365.9 339.1 354.3 0.019 0.019 0.017 0.014 0.016 0.020 0.027 0.024 0.023 0.012 0.021 1287 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL FINAL BODY AMD ORGAN WEIGHTS - Pi ADULTS FINAL BODY AMD ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP: IV-0 643399 643334 643464 643369 643490 643342 643438 643418 643325 643479 643376 643452 643475 643372 643400 643395 643457 25 mg/kg/day 342.4 355.0 391.5 377.9 353.7 381.8 352.0 3.46.4 405.7 358.6 366.9 375.0 388.9 346.7 356.0 350.5. 371.1 0.021 0.021 0.024 0.016 0.020 0.022 0.029 0.017 0.021 0.027 0.018 0.020 0.022 0.018 0.026 0.016 0.023 1288 Company Sanitized. Does not eontain T8CA CBI H-24516: Subchromc Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - PI ADULTS FINAL BODY AMD ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP: VI-0 ANIMAL NUMBER 100 mg/kg/day FINAL BODY THYROID GLAMD 643320 643428 643439 643353 643339 643337 643416 643427 643434 643349 643333 643460 367.8 380.6 363.0 360.9 353.0 381.7 341.5 329.2 360.8 365.2 346.8 360.0 0.019 0.018 0.024 0.021 0.016 0.017 0.024 0.016 0.026 0.018 0.025 0.019 1289 Company Sanitized. Does not contain TSCA CBI H-24516: Subcbromc Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Pi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP: VIII-0 ANIMAL NUMBER 250 mg/kg/day FINAL BODY THYROID GLAND 643467 643443 643417 643413 643338 643335 643468 643440 643326 643365 643328 643449 345.4 259.3 306.4 283.6 357.6 362.4 319.3 390.6 361.5 380.5 312.4 377.1 0.025 0.013 0.013 0.028 0.026 0.018 0.027 0.024 0.025 0.024 0.019 0.019 1290 Sompany Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations GROUP: 1-1 ANIMAL NUMBER 647068 647069 647070 647071 647072 647073 647074 647075 647076 647077 647078 647079 647080 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM MALE RATS 0 mg/kg/day FIN.AL BO:DY L IVER KIDNEYS THYROID GLAMD PROSTATE SEMINAL VESICLES TE,STES 329 .2 446 .1 387 .8 407 .7 407 .3 362 .9 396 .7 352 .3 353 .4 407 .4 389 .7 400 .4 361 .8 14 .069 20 .638 16 .432 16 .834 17 .318 17 .748 18 .285 16 .343 16 .544 20 .000 19 .329 18 .551 15 .250 2.789 3.502 3.105 3.384 3.355 3.455 3.555 2.889 3.145 3.767 3.141 3.562 3.030 0.023 0.021 0.013 0.020 0.015 0.021 0.019 0.020 0.021 0.010 0.020 0.023 0.020 0.314 0.616 0.474 0.412 0.508 0.520 0.494 0.487 0.279 0.526 0.692 0.409 0.255 1.001 1.574 0.963 1.186 1.377 1.186 1.537 1.047 0.929 1.180 1.288 1.258 1.070 3 .209 3 .859 3 .296 3 .440 3 .407 3 .071 3 .543 3 .031 3 .109 3 .388 3 .137 3 .211 3 .204 EPIDI DYM 0. 724 0. 867 0. 742 0. 886 0. 777 0. 747 0. 763 0. 688 0. 645 0. 711 0. 825 0. 759 0. 750 1291 Company Sanitized. Does not cont H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Pi ADULTS FINAL BODY AMD ABSOLUTE ORGAN WEIGHTS (grams) FROM MALE RATS GROUP: III-1 - ANIMAL NUMBER 25 nig/kg/day FIN-&L BO:DY L IVER KID:NEYS THY:ROID G:LAND PROS'TATE SEM INAL VESI'CLES TE,STES 647123 647124 647125 647126 647127 647128 647129 647130 647131 647132 647133 647134 647135 647136 647137 647138 357 .6 379 .4 361 .1 369 .9 378 .6 382 .2 362 .2 392 .4 423 .8 373 .8 368 .5 412 .5 359 .5 308 .0 355 .6 37.2 .3 15 .301 17 .911 15 .145 16 .166 19 .171 18 .457 16 .122 20 .397 18 .465 16 .868 14 .743 18 .666 15 .014 13 .994 17 .132 17 .458 3 .083 2 .654 3 .131 3 .005 3 .497 3 .307 3 .140 2 .828 3 .574 3 .283 3 .234 3 .514 3 .303 2 .753 3 .071 3 .085 0 .019 0 .018 0 .018 0 .013 0 .016 0 .015 0 .018 0 .017 0 .017 0 .027 0 .018 0 .011 0 .015 0 .014 0 .018 0 .015 0 .464 0 .355 0 .453 0 .278 0 .448 0 .517 0 .543 0 .487 0 .502 0 .303 0 .362 0 .417 0 .342 0 .312 0 .347 0 .407- 1 .034 0 .792 1 .136 0 .925 0 .941 1 .435 1 .202 1 .287 1 .375 1 .051 0 .849 1 .270 1 .137 0 .844 0 .836 1 .068 3 .022 3 .220 2 .977 3 .061 3 .045 3 .052 3 .150 3 .297 3 .442 3 .142 3 .309 3 .386 3 .117 2 .731 3 .233 3 .283 EPID IDY 0 .75 0 .68 0 .80 0 .62 0 .68 0 .84 0 .72 0 .81 0 .83 0 .82 0 .78 0 .77 0 .75 0 .54 0 .57 0 .76 1292 Company Sanitized. Does not H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Pi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM MALE RATS GROUP: V-l - ANIMAL NUMBER 100 mg/kg/day FIN, AL BO:DY L IVER KIDNEYS THY:ROID G:LAND PROS TATE SEM INAL VESI CLES TE STES 647184 647185 647186 647187 647188 647189 647190 647191 647192 647193 647194 647195 337 .6 366 .8 330 .2 418 .8 422 .4 367 .0 366 .3 382 .6 386 .4 379 .5 380 .4 375 .6 11 .604 16 .720 13 .625 18 .190 22 .330 16 .428 16 .743 19 .704 17 .954 17 .448 18 .392 16 .066 3.114 3.256 2.826 3.674 3.652 2.918 3.479 3.053 3.115 2.912 3.415 2.976 0 .022 0 .018 0 .015 0 .015 0 .017 0 .012 0 .006 0 .013 0 .016 0 .021 0 .016 0 .013 0 .298 0 .448 0 .248 0 .325 0 .365 0 .308 0 .341 0 .349 0 .389 0 .309 0 .531 0 .509 0 .911 1 .150 0 .734 1 .342 1 .518 1 .027 0 .931 1 .013 0 .822 1 .060 1 .537 0 .978 3 .211 3 .375 3 .058 3 .265 3 .079 3 .168 3 .568 3 .154 3 .132 2 .851 3 .781 2 .997 EPID IDYM 0 .69 0 .774 0 .690 0 .753 0 .794 0 .782 0 .728 0 .726 0 .72 0 .659 0 .824 0 .70 1293 Company Sanitized. Does no H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations GROUP: VI I-1 ANIMAL NUMBER 647230 647231 647232 647233 647234 647235 647236 647237 647238 647239 647240 647241 INDIVIDUAL AMIMAL FINAL BODY AMD ORGAN WEIGHTS - FI ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) PROM MALE RATS 250 ing/kg/day FINAL BODY LIVER KID:NEYS THYROID GLAND PROS TATE SEM INAL VESI'CLES TE STES 351.2 362.1 470.3 346.4 367.7 338.8 336.0 344.6 327.9 361.9 352.9 364.7 16.054 15.376 19.170 14.994 15.545 15.621 17.685 14.558 15.967 15.602 15.802 16.070 3 .249 3 .175 3 .832 3 .064 3 .271 2 .961 3 .348 3 .205 3 .314 3 .513 2 .753 3 .348 0.018 0.018 0.022 0.014 0.026 0.014 0.018 0.021 0.022 0.020 0.010 0.018 0 .459 0 .495 0 .667 0 .470 0 .494 0 .385 0 .280 0 .362 0 .315 0 .300 0 .275 0 .368 1 .196 1 .243 1 .257 1 .190 1 .050 1 .397 0 .891 0 .878 1 .175 0 .881 1 .040 0 .809 2 .631 3 .093 4 .208 2 .779 2 .796 2 .566 3 .210 3 .334 2 .955 2 .877 2 .801 3 .217 EPID IDYM 0 .728 0 .643 0 .857 0 .659 0 .663 0 .715 0 .684 0 .717 0 .676 0 .655 0 .629 0 .603 1294 Company Sa-'t^ed. Does not cw H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP: II-l - AMIMAL NUMBER 0 mg/kg/day PIN.KL BO:DY L IVER KID:NEYS THYH.OID GtAMD UT ERUS BRAIN 647277 647278 647279 647280 647281 647282 647283 647284 647285 647286 647287 647288 647289 205 .8 211 .3 190 .2 228 .3 227 .6 223 .5 231 .4 215 .5 198 .6 250 .7 242 .5 230 .8 183 .4 8 .850 9 .353 6 .655 8 .919 8 .715 9 .397 10 .733 9 .492 7 .356 9 .956 9 .866 11 .434 7 .093 1 .717 1 .697 1 .878 1 .882 1 .947 1 .926 2 .094 1 .921 1 .647 1 .902 1 .851 2 .216 1 .838 0. 014 0. 017 0. 016 0. 021 0. 020 0. 015 0. 014 0. 017 0. 017 0. 017 0. 014 0. 015 0. 009 0 .356 0 .380 0 .465 0 .643 0 .470 0 .389 0 .463 0 .354 0 .418 0 .329 0 .539 0 .371 0 .406 1.756 1.883 1.948 1.817 1.811 1.795 1.923 1.848 1.772 1.836 1.853 1.764 1.769 1295 CompanySanded. Does H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fi ADULTS FINAL BODY AMD ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP: IV-1 - 25 nig/kg/day ANIMAL NUMBER FINAL BODY LIVER KIDNEYS THYROID GLAND UTERUS BRAIN 647326 647327 647328 647329 647330 647331 647332 647333 647334 647335 647336 647337 647338 647339 647340 647341 647342 209.6 234.8 217.0 239.8 230.5 286.7 261.3 208.0 278.6 203.7 171.9 238.3 215.0 201.8 201.1 212.4 232.7 9.907 9.838 9.399 9.492 10.921 12.292 10.396 7.671 12.246 7.800 6.831 12.077 8.056 8.438 7.467 9.262 10.916 1.905 2.037 2.149 2.030 2.146 2.596 2.179 1.943 2.421 1.945 1.695 2.125 1.856 1.756 1.697 1.858 2.303 0.015 0.012 0.011 0.016 0.017 0.011 0.016 0.020 0.013 0.013 0.020 0.013 0.018 0.019 0.008 0.013 0.018 ' 0.428 0.421 0.263 0.854 0.631 0.410 0.510 0.545 0.570 0.488 0.580 0.357 0.401 0.324 0.341 0.398 0.477 1.905 1.822 1.825 1.829 1.867 1.920 1.935 1.962 1.889 1.859 1.794 1.890 1.959 1.715 1.676 1.746 1.848 1296 Company Sanitized. Does not co H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations GROUP: VI-1 ANIMAL NUMBER 647394 647395 647396 647397 647398 647399 647400 647401 647402 647403 647404 647405 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fi ADULTS FINAL BODY AMD ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS 100 nig/kg/day FIN. AL BO:DY L IVER KID:NEYS THYK.OID GLAND UT ERUS BRAIN 224 .5 229 .7 215 .9 193 .7 250 .9 249 .5 219 .5 235 .4 228 .7 187 .1 212 .8 237 .3 8 .740 8 .193 8 .707 8 .560 12 .280 11 .101 10 .179 10 .573 10 .055 7 .631 9 .426 9 .675 2 .052 2 .029 1 .999 2 .236 2 .284 2 .028 2 .326 1 .981 2 .470 1 .603 1 .832 1 .774 0. 020 0. 014 0. 017 0. 012 0. 014 0. 011 0. 014 0. 021 0. 018 0. 018 0. 014 0. 021 0 .561 0 .555 0 .612 0 .361 0 .357 0 .350 0 .326 0 .445 0 .498 0 .428 0 .610 0 .294 1.989 1.735 1.914 1.743 1.875 1.712 1.702 1.755 1.780 1.784 1.869 1.730 1297 Company SanV-wti F"es mot H-54516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations GROUP: VIII-1 ANIMAL NUMBER 647436 647437 647438 647439 647440 647441 647442 647443 647444 647445 647446 647447 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - FI ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS 250 mg/kg/day FIN-M, BO:DY L IVER KID]KIEYS THY:ROID G:LAND UT;ERUS B:RAIN 237 .0 203 .8 249 .1 204 .8 234 .5 226 .8 201 .9 219 .0 216 .4 230 .5 213 .0 232 ,9 10 .811 7 .861 9 .966 10 .391 11 .348 9 .620 8 .987 10 .929 9 .820 10 .745 9 .512 9 .845 2 .189 1 .892 2 .169 2 .043 2 .043 1 .880 1 .794 2 .199 2 .062 2 .407 1 .628 2 .157 0 .013 0 .012 0 .013 0 .009 0 .012 0 .016 0 .012 0 .018 0 .014 0 .011 0 .012 0 .014 2 .487 0 .472 0 .496 0 .348 0 .351 0 .329 0 .471 0 .392 0 .367 0 .348 0 .395 0 .535 1 .819 1 .920 1 .746 1 .765 1 .882 1 .874 1 .742 1 .800 1 .823 1 .816 1 .768 1 .769 1298 QompasssSanitized. Does not con APPENDIX NN INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS 1299 Company SanWced. Does not <wna!n TSCA CBI INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Pi ADULTS EXPLANATORY NOTES Abbreviations AK = FD = SD = Accidentally killed Found dead Sacrificed by design 1300 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL ft: 643147 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NOME THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OP THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1301 Company Sanitized. Does not contain TSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643148 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: NONE3 MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: HONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE a No gross observations were entered into the database at the time of necropsy. However, protocol tissues were saved and no abnormalities were detected when these tissues were re-examined. 1302 Company Sanitized. Does not contain TSCA CB8 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ___________DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643155 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1303 Company Sanitized. Does not contain TSCA CBS H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS DuPont-5386 ___ - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643163 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES COAGULATING GLAM), THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NOME THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OP THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1304 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 nig/kg/day ANIMAL #: 643176 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NOME THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIS, PROSTATE, SEMINAL VESICLES, TESTIS COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLY2ED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OP THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1305 Company Sanitized. Does not contain TSCA CBI H-24516: Subchromc Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643196 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: PROSTATE - INFLAMMATION, SUBACUTE/CHRONIC, MINIMAL THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIS, SEMINAL VESICLES, TESTIS COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1306 Company Sanitized. Does not eontaSa TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643197 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN MOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1307 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toricity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 ____ INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL ft: 643207 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID HOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1308 Company Sanitized. Does rot contain TSCA CBI H-24516: Subchromc Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ___________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643211 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OP AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN MOT COUNTED IN INCIDENCE TABLES: NONE 1309 Company Sanitized. Does not eontain T8CA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ___ INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - DuPont-5386 Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643218 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OP THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1310 Company SanHfeed. Does rot contato TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DiLPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643229 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1311 Company SanWzed. Does not contain TSCA CBS H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations _____DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643239 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIS, PROSTATE, SEMINAL VESICLES, TESTIS COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1312 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643242 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1313 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations___ __________DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 ing/kg/day ANIMAL #: 643251 DAYS OS TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): MO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID MOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE MOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1314 Company Sa"W*<rf. Rnnc nnf 4*nnfa>n T<i('*a CjM H-24516: Subchronic Toxicity __ 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 nig/kg/day ANIMAL #: 643254 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CMl""ys"l"^KD.-----TSCACB, H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643270 DAYS ON TEST: 107 MODE OP DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NOME THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NOME THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID MOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1316 Company SanFtized. Does not contain TSCA CBt H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ____DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643271 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): HO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NOME 1317 Company Sair'l'zed. Does not contain T8CA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643276 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OP AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN MOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1318 Company SanWzed. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations __ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - DuPont-5386 ____ Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643280 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NOME THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1319 .CompanySanitized. Does not contain TSCA CBJ H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - P,. ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643284 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIS, PROSTATE, SEMINAL VESICLES, TESTIS COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OP AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: ' " NONE 1320 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643144 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions) : NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NOME THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED,- ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OP THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1321 Company SanSfaed. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 25 nig/kg/day ANIMAL #: 643153 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OP THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1322 cllmpa"ys""BI^AD<om*T8CACB, H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643166 DAYS OM TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OP AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1323 Company Sanitized. Does noteontain T8CACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643167 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OP THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1324 Company Sanitized. Does not contain T8CA CBI H-24516: Subchronic Toxichy 90-Day Gavage Study m Rats with One-Generation Reproductive Evaluations ___ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - DuPont-5386 ___ Pi ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643170 DAYS ON TEST: 107 MODE OP DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1325 Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations _____________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643177 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IH INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OP THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1326 Company Sanitized. Does not contain TSGA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL AMIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643183 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLY2ED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NOME MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NOME 1327 Company San?tized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643184 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1328 Company Sanded. Does not contain TSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643188 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OP AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1329 (^^^.-.Doe^c"*^0" H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643198 DAYS ON TEST: 109 MODE OP DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: -NONE 1330 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643214 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OP AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IM INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1331 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - PI ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643219 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IKf INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES MOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1332 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity ___ 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____ INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - ____DuPont-5386 Pi ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643223 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: MONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1333 Company Sanitized. Does not contain TSCA CBi H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643230 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OP AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1334 Company Sanitized. Does not contain TSCA CBI H-24516: Subchromc Toxicity 90-Day Gavage Study m Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - PI ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643233 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): MO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OP THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1335 Company San?aized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643261 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): WO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIS, PROSTATE, SEMINAL VESICLES, TESTIS COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED,- ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NOME SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1336 Company San''Sizeti. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - PI ADULTS MALE RATS GROUP: III-O DOSE: 25 nig/kg/day ANIMAL #: 643263 DAYS ON TEST: 109 MODE OP DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1337 Company Sanded. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643277 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLY2ED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1338 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643287 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED,- ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1339 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 25 ing/kg/day ANIMAL #: 643291 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions) : NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLY2ED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1340 Company s"wiA Does oof contain TSCA CBI H-24516: Subchromc Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - PI ADULTS MALE RATS GROUP: V-0 DOSE; 100 mg/kg/day ANIMAL #: 643146 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NOME SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN MOT COUNTED IN INCIDENCE TABLES: NONE 1341 tSwn^ny Sa^ed. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations _____DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643154 DAYS OM TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OP THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1342 Compaw Sanded, oggg ^ contain T8CA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643156 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): MO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OP AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN MOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1343 CCTWWW fifliM..a< nna mnf ftfwrfqht TSCA CBI Company SanP?ed. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643157 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IM INCIDENCE TABLES: NONE 1344 Comnany Saw't'-'ed. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - PI ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643164 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OP AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1345 Company Sanitized. Does not contain TSCA GBi H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643182 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIS, PROSTATE, SEMINAL VESICLES, TESTIS COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NOME SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IM INCIDENCE TABLES: NONE 1346 .Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643190 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: MONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1347 Company Sanitized. Does net contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL ft: 643199 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): MO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NOME THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OP AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1348 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643200 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OP AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1349 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 100 ing/kg/day ANIMAL #: 643208 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): MO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1350 Company San't'zed. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643216 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES MOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NOME 1351 iComoany SanWsred. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - PI ADULTS MALE RATS GROUP: V-0 DOSE: 100 nig/kg/day ANIMAL #: 643227 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NOME MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1352 Company Sanitized. Does not contain TSCA CBI H-24516; Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations__________ DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643238 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OP AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE .353 '^'^"""^^no.^,^^^ H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL ft: 643244 DAYS OM TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: PROSTATE - INFLAMMATION, SUBACUTE/CHRONIC, MINIMAL THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIS, SEMINAL VESICLES, TESTIS COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1354 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643245 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1355 Company SanRfeed. Doe net contain T8CA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations _____________DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643255 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLY2ED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1356 Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643267 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NOME THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIS, PROSTATE, SEMINAL VESICLES, TESTIS COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1357 Company Saitfzed. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 100 nig/kg/day ANIMAL #: 643301 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OP THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1358 Compainy ga"'''efril- Does) not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643312 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NOME THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OP THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1359 Company San^feed. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day AMIMAL #: 643313 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions) : NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NOME THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: HONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NOME MICROSCOPIC DIAGNOSES MOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMIMATIOM: NOME SECTIONS OF THE FOLLOWING TISSUES WERE IMSUFFICIEMT FOR MICROSCOPIC EXAMIMATIOM; ORGAN NOT COUNTED IM INCIDENCE TABLES: NOME 1360 - Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643158 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1361 ^^^SanilfceADo^noteonfalnTSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643160 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OP THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1362 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643161 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NOME THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OP THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN MOT COUNTED IN INCIDENCE TABLES: NONE 1363 Company aiW%ed. Does not cantato T8CA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VI I-0 DOSE: 250 ing/kg/day ANIMAL #: 643171 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions) : NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NOME THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN MOT COUNTED IM INCIDENCE TABLES: NOME MICROSCOPIC DIAGNOSES MOT MADE, SECTIONS OP THE POLLOWIMG TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OP THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION,- ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1364 Company Sanitized. Does not contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 250 ing/kg/day ANIMAL ft: 643191 DAYS ON TEST: 109 MODE OF DBATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE "5 '"^s^.^.o^^ ''"'*" ^A CBt H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 250 ing/kg/day ANIMAL #: 643192 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1366 Company Sanitized. Does not contain TSGA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643203 DAYS ON TEST: 109 MODE OP DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OP THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1367 Company Sanitized. Does not contain TSCACB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VI I-0 DOSE: 250 mg/kg/day ANIMAL #: 643222 DAYS OH TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NOME THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES MOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1368 CompanySanitized. Does not contain TSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VI I-0 DOSE: 250 mg/kg/day ANIMAL #: 643248 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NOME THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1369 Company Sanitized,, Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - PI ADULTS MALE RATS GROUP: VI I-0 DOSE: 250 mg/kg/day ANIMAL #: 643249 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN MOT COUNTED IN INCIDENCE TABLES: NOME MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1370 Company Sanitized. Does not eonlaBn TSCA CBI H-24516: Subcbronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VI I-0 DOSE: 250 nig/kg/day ANIMAL ft: 643274 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NOME THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN MOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN MOT COUNTED IN INCIDENCE TABLES: NONE 1371 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VI I-0 DOSE: 250 mg/kg/day ANIMAL #: 643278 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: PROSTATE - INFLAMMATION, SUBACUTE/CHRONIC, MINIMAL THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIS, SEMINAL VESICLES, TESTIS COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: MONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IM INCIDENCE TABLES: NONE 1372 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 250 ing/kg/day ANIMAL #: 643281 DAYS ON TEST: 109 MODE OP DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE MOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1373 Company Sanitized. Does not contain TSCA CB! H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643282 DAYS OM TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OP THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NOME 1374 Company Sanitized. Does not contain TSCA CBi H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643285 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE EPIDIDYMIDES (selected lesions): - LARGE, RIGHT; HEAD MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: HONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OP AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OP THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: MONE 1375 Company Sanitized. Does not contain TSCA CB8 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VI I-0 DOSE: 250 ing/kg/day ANIMAL ft: 643289 DAYS ON TEST: 107 MODE OP DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: HONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1376 Company Sa-Wzed. Does not contain TSCA CB! H-24516: Subchromc Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643299 DAYS ON TEST: 108 MODE OP DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIS, PROSTATE, SEMINAL VESICLES, TESTIS COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1377 Company Sanitized. Does not contain TSCA C@l H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 250 nig/kg/day AMIMAL #: 643302 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLY2ED; DEGREE OP AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED? ORGAN NOT COUNTED IM INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OP THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1378 Company Sanitized. Does not contain TSCA CBi H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - PI ADULTS MALE RATS GROUP: VI I-0 DOSE: 250 ing/kg/day ANIMAL #: 643317 DAYS ON TEST: 109 MODE OP DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NOME THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1379 '^^^^r^^ H-24516: SubchronicToxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 643319 DAYS ON TEST: 119 MODE OP DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: VAGINA OVARIES, UTERUS, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN MOT COUNTED IN INCIDENCE TABLES: NONE 1380 Comnaww ^nffi-narf. no< nnf ri'mfain TSCA CCT H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-0 DOSE: 0 mg/kg/day ANIMAL #: 643343 DAYS ON TEST: 122 MODE OP DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1381 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 ____ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 643350 DAYS ON TEST: 119 MODE OP DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: VAGINA OVARIES, UTERUS, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NOME THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IM INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OP THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE ^^ompanySam-SEasecSD. oes wi contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Stiidy in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 643352 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: VAGINA OVARIES, UTERUS, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OP AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1383 Company Sanitized. Does not contain TSCA CB8 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - PI ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 643363 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NOME SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1384t , Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 643378 DAYS ON TEST: 125 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION,- ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 138SCompany Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-O DOSE: 0 ing/kg/day ANIMAL ft: 643386 DAYS ON TEST: 126 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED,- DEGREE OP AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN MOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE MOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OP THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1386 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - PI ADULTS FEMALE RATS GROUP: II-0 DOSE: 0 mg/kg/day ANIMAL ft: 643393 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: VAGINA OVARIES, UTERUS, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION,- ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1387 conwr SMBlrt-~-" ~nMn WC C H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 643394 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: VAGINA OVARIES, UTERUS, THE FOLLOWING TISSUES WERE AUTOLYZED,- DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1388 t^any Sanded. Doe. not certain T8CACBI H-24516: Subchronic Toxicity 9g-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-O DOSE: 0 ing/kg/day ANIMAL #: 643397 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE LIVER (selected lesions): - DISCOLORATION, TAN, MOTTLED, LEFT MICROSCOPIC OBSERVATIONS: OTHER - LIVER: NECROSIS, FOCAL, MINIMAL THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: VAGINA OVARIES, UTERUS, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1389 Company San'f'zed. Does not contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-0 DOSE: 0 mg/kg/day ANIMAL #: 643401 DAYS OM TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OP AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1390 Com'^nv s<"*'w< nno^ nnt contain T8CA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ____________DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL tt: 643414 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: VAGINA OVARIES, UTERUS, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OP THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1391 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-O DOSE: 0 nig/kg/day ANIMAL #: 643419 DAYS OM TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1392 company Sanitized. Does not contain TSCA GBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations _____ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - _____DuPont-5386 Pi ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 643420 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE SKIM (selected lesions): - ALOPECIA, PERINEUM; RIGHT FRONT LIMB MICROSCOPIC OBSERVATIONS: OTHER - SKIN: NO ABNORMALITIES DETECTED THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: VAGINA OVARIES, UTERUS, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OP AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1393 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 643421 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NOME THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1394 notconlataTSCACBl eonipanySa""^0068 H-24516: Subchronic Toxicity 90-Day Gavage Study m Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 643447 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OP THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1395 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 643455 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NOME MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1396 Company Sanitized. Does not ewtatn TSCA C8I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 643459 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1397 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 643478 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OP AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OP THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1398 Company Sanitized. Does noS contain T8CA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations _____ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi DuPont-5386 ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 643480 DAYS ON TEST: 122 MODE OP DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1399 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ____________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - PI ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 nig/kg/day ANIMAL #: 643325 DAYS ON TEST: 123 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OP THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1400 Company Sanitized. Does noS eontain TSCA CBI H-24516: Subchronic Toxidty 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL fiMIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 nig/kg/day ANIMAL ft: 643334 DAYS ON TEST: 120 MODE OP DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSXXBS WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NOME THE FOLLOWING TISSTIES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OP THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: HONE SECTIONS OP THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN MOT COUNTED IN INCIDENCE TABLES: NONE 1401 eommmy Sanitized. Does nd contain T8CA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - PI ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643342 DAYS ON TEST: 123 MODE OP DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1402 Company Sanitized. Does not contain TSCA CB! H-24516: Subchromc Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 nig/kg/day ANIMAL #: 643369 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OP THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1403 Company Sanifced. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643372 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions) : NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OP THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NOME 1404 e^Pany Sanifaed. Does not contain TSCA CB H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643376 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1405 Company Sanitized. Does not contain T8CA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats witfa One-Generation Reproductive Evaluations __________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 ing/kg/day ANIMAL #: 643395 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1406 '"< contain TSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 ing/kg/day ANIMAL #: 643399 DAYS ON TEST: 132 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1407 Company Sam-feed. Does not contain TSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643400 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NOME THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1408,, Bany san!lteed- Ooes no,conta,n TSCACBt H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ___ _______DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643403 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: VAGINA OVARIES, UTERUS, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OP THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC ! EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1409 Company Sanitized. Does not contain T8CACBI H-24516: Subchromc Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 nig/kg/day ANIMAL #: 643418 DAYS ON TEST: 125 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES'WERE AUTOLYZED; DEGREE OP AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1410 ccamvswa^^^^^ H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - PI ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643422 DAYS ON TEST; 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: VAGINA OVARIES, UTERUS, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1411 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 nig/kg/day ANIMAL #: 643438 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN MOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1412 Company Sanitized. Does not contain TSCA CB! H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS . GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643445 DAYS ON TEST: 119 GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MODE OF DEATH: SD MICROSCOPIC OBSERVATIONS: UTERUS - DILATATION, GLAND/LUMEN, MINIMAL THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OP THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1413 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643452 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1414 ^PanySanRfeed. Does not eontatoTSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AM) MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643457 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NOME THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES; NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1415 6mpany Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643464 DAYS ON TEST: 121 MODE OP DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION; NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1416 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: -25 mg/kg/day ANIMAL #: 643475 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OP AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NOME THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC'DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE MOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1417 Compaq SanlW. Does not contain TSCA CBI H-24516: Subchronic Toxidty 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations __________DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643479 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OP THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE ^ " " ^ 1418 c^ offiparay ^ "Contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 ing/kg/day ANIMAL #: 643490 DAYS OM TEST: 119 MODE OP DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): SO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OP THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1419 (BotconlalnTSCACBJ H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643320 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions) : NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OP THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1420 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643331 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: VAGINA. OVARIES, UTERUS, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OP THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OP THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1421 cw----------------^^ H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643333 DAYS OK TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): HO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NOME THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES; NONE 1422 Company Sanitized. Doe rot contain TSCA CBI H-24516: Subchronic Toxidty 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL ft: 643337 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): MO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: HOME THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NOME SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1423 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643339 DAYS OM TEST: 120 MODE OP DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: HONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE ">24 eMvmwsl.D^ ""MnrscAcm H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643349 DAYS ON TEST: 121 MODE OP DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OP THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE ~^5^""Pahy Sanitized ^ ^"^"^T^CB, H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - PI ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643353 DAYS ON TEST: 120 MODE OP DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: HONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - ca^.^^----^^ H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations _________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 nig/kg/day ANIMAL #: 643357 DAYS OM TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: UTERUS - DILATATION, GLAMD/LUMEN, MINIMAL THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID MOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1427 ^oesnotcomafnTSCACBI H-24516: SubchronicToxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643385 DAYS OM TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: VAGINA OVARIES, UTERUS, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NOME THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1428 Company Sanitized. Does not contain TSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643407 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: VAGINA OVARIES, UTERUS, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OP AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OP THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1429 Company Sanitized. Does not contain T8CA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day AMIMAL #: 643416 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OP AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: MONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES MOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1430 ^"PanySanftfeed.DoesnotcomafnTSCAC H-24516: Subchromc Toxicity 90-Day Gavage Stady in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643427 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORREIATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1431 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643428 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NOME THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IM INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NOME 1432 Company Sanitized. Does not contain T8CA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643434 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1433 eompany 8anw2ed- ^ not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643439 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1434 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - PI ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643454 DAYS ON TEST: 99 MODE OF DEATH: FD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE SKIN (selected lesions): - STAIN, RED, FACE MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: VAGINA OVARIES, UTERUS, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1435 Company Sanitized. Does not contain T8CA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643460 DAYS ON TEST: 120 MODE OP DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID MOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLY2ED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES MOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1436 contain T8CACBS H-24516: Subchronic Toxicity 90-Day Gavage Study m Rats with One-Generation Reproductive Evaluations _____ DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643470 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: VAGINA OVARIES, UTERUS, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OP THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1437 Company Sanded. Do^ n,em*.^ TSCA CTffi H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - PI ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643473 DAYS OH TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: UTERUS - DILATATION, GLAND/LUMEN, MILD THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN MOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES MOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1438 C^ ompany sanfflzed. Doe,no,e^n^CACBI H-24516: Subchronic Toxicity 90-Day Gavage Stady m Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643488 DAYS OM TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: UTERUS - DILATATION, GLAND/LUMEN, MILD THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN MOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN .NOT COUNTED IN INCIDENCE TABLES: NONE 1439 ^"^Santed.Doesnotcontah^CACBt H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643326 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN MOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1440 <?mtanw <Qi<m(n;,cuf Gonmamue_...__*w. . -nnnavsnnf wna?r"e"T'<&wp-as ,,ft,f,tr, lcQ!^a^SCACB^ H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - PI ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 ing/kg/day ANIMAL #: 643328 DAYS ON TEST: 121 MODE OF DBATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONB 1441 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - PI ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643335 DAYS ON TEST: 121 MODE OP DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID MOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1442 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - PI ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day AMIMAL #: 643338 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OP AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN MOT COUNTED IN INCIDENCE TABLES: NONE 1443 Comoany SanWzed. Does not contain TSCA CBI H-24516: Subchromc Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643346 DAYS ON TEST: 91 MODE OF DEATH: AK GROSS OBSERVATIONS: MICROSCOPIC CORRELATE STOMACH SMALL INTESTINE SKIN (selected lesions): - DISTENDED WITH GAS, - DISTENDED WITH GAS, - STAIN, RED, FACE SEVERE SEVERE MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NOME THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1444 ^^'^'^Doeanot^teinTSCACBI' H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS . GROUP: VIII-0 DOSE: 250 mg/kg/day AMIMAL ft: 643348 DAYS OM TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NOME THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: VAGINA OVARIES, UTERUS, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NOME THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1445 "P^iMM^D^------^^ H-24516: Subchromc Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - PI ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 nig/kg/day ANIMAL #: 643365 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1446 Company Sanltfaed. Does not contain TSCA CBj H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643375 DAYS ON TEST: 121 MODE OP DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: VAGINA OVARIES, UTERUS, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OP THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1447 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - PI ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643413 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1448 twnr 1E'*--Mmf Wftnft t inWHSaSn T<SMl WSS ^em^aBf^arafflgedrgaea. w'i w9Sn' H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643417 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1449 Company Sanitized. Does not contain TSGA CBl H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 nig/kg/day ANIMAL #: 643424 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: VAGINA OVARIES, UTERUS, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1450 Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 ing/kg/day ANIMAL ft: 643429 DAYS ON TEST: 106 MODE OF DEATH: FD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE KIDNEYS UTERUS SKIN (selected lesions): - DILATATION, BILATERAL, PELVIS - HEMORRHAGE - OBSTRUCTION, BODY; PLACENTA - STAIN, RED, VENTRAL BODY, FACE MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID MOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1451 ^'"P^^^Uzed.^oes not contain TSCA CBi H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - PI ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 nig/kg/day ANIMAL #: 643430 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: VAGINA OVARIES, UTERUS, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1452 Company Sanitized. Does not eontein TSCA CBI -- i!K H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ___________DuPont-5386 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 ing/kg/day ANIMAL #: 643431 DAYS ON TEST: 119 MODE OP DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: VAGINA OVARIES, UTERUS, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OP THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OP THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1453 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - PI ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643440 DAYS ON TEST: 122 MODE OP DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID MOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OP THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBJ H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643443 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1455 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643449 DAYS ON TEST: 125 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1456 c^^s^.-.oo"'"'1"'*^01'1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643467 DAYS ON TEST: 125 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OP THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1457 Company Sanitized. Does not contain TSCA CB8 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643468 DAYS ON TEST: 125 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MICROSCOPIC DIAGNOSES NOT MADE, SECTIONS OF THE FOLLOWING TISSUES WERE MOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NOME 1458 Company Sanitized. Does not contain TSCA CBi APPENDIX 00 INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi PUPS 1459 Company Sanitized. Does not contain TSCA CBI INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi PUPS EXPLANATORY NOTES Abbreviations FD = Found dead 1460 Company Sanitized. Does no! contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Pi PUPS DAM GROUP: II-O DOSE: 0 MG/KG/DAY DAM ANIMAL NUMBER PUP SEX PUP ANIMAL NUMBER DAYS ON TEST FATE OBSERVATIONS 643455 M 647028 -21 FD NO ABNORMALITIES DETECTED 1461 Company Sanitized. Does not contain T8CA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi PUPS DAM GROUP: IV-0 DOSE: 25 MG/KG/DAY DAM ANIMAL NUMBER PUP SEX PUP ANIMAL NUMBER DAYS ON TEST FATE OBSERVATIONS 643376 M 647033 -21 FD 643400 M 647034 -21 FD STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED 1462 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DAM ANIMAL NUMBER PUP SEX INDP7IDUAL AN[IMAL GR(3SS OBSERVATIONS - Fi PUPS DAM GROUP: VI-0 DOSE: 100 MG/KG/DAY PUP ANIMAL NUMBER DAYS ON TEST FATE OBSERVATIONS 643320 M 647042 -21 FD F 647052 -21 FD 643439 M 647036 -21 FD 647037 -21 FD F 647056 -21 PD 647057 -21 FD 643331 M 647038 -21 FD 647039 -21 FD 647040 -21 FD 647041 -21 FD F 647058 -21 PD 647059 -21 FD 647060 -21 FD 647061 -21 FD 647062 -21 FD NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED STOMACH LUNGS STOMACH LUNGS STOMACH LUNGS STOMACH LUNGS STOMACH LUNGS STOMACH LUNGS STOMACH LUNGS STOMACH LUNGS STOMACH LUNGS - - NO MILK SPOT NOT EXPANDED - NO MILK SPOT NOT EXPANDED - NO MILK SPOT NOT EXPANDED - NO MILK SPOT NOT EXPANDED - NO MILK SPOT NOT EXPANDED - NO MILK SPOT NOT EXPANDED - NO MILK SPOT NOT EXPANDED - NO MILK SPOT NOT EXPANDED - NO MILK SPOT NOT EXPANDED DuPont-5386 1463 Company Sanitized. Does not contain TSCA CBS H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DAM ANIMAL NUMBER PUP SEX INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi PUPS DAM GROUP: VIII-0 DOSE: 250 MG/KG/DAY PUP ANIMAL NUMBER DAYS ON TEST FATE OBSERVATIONS DuPont-5386 643326 M 647046 -21 FD STOMACH - NO MILK SPOT LUNGS - MOT EXPANDED 643365 M 647047 -21 PD STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED 643375 M 647043 -21 FD 647044 -21 FD 647045 -21 FD 647063 -21 FD NO ABNORMALITIES DETECTED PERITONEAL CAVITY - CANNIBALIZED STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED 643429 647065 -21 FD 647066 -21 FD 647067 -21 FD U 647029 -21 FD NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED PUP APPEARS PREMATURE WHOLE BODY - AUTOLYSIS, SEVERE 647030 -21 PD PUP APPEARS PREMATURE WHOLE BODY - AUTOLYSIS, SEVERE 647031 -21 FD PUP APPEARS PREMATURE WHOLE BODY - AUTOLYSIS, SEVERB 647032 -21 FD - WHOLE BODY - AUTOLYSIS, SEVERE 647048 -21 FD WHOLE BODY - AUTOLYSIS, SEVERE 647049 -21 FD NO ABNORMALITIES DETECTED 647050 -21 FD 647051 -21 FD NO ABNORMALITIES DETECTED PUP APPEARS PREMATURE WHOLE BODY - AUTOLYSIS, SEVERE 647035 -21 FD PUP APPEARS PREMATURE WHOLE BODY - AUTOLYSIS, SEVERE 647053 -21 FD 647054 -21 FD 647055 -21 FD WHOLE BODY - AUTOLYSIS, SEVERE NO ABNORMALITIES DETECTED PUP APPEARS PREMATURE WHOLE BODY - AUTOLYSIS, SEVERE 647064 -21 FD PUP APPEARS PREMATURE WHOLE BODY - AUTOLYSIS, SEVERE 1464 Company Sanitized. Does not contain TSCA CBf APPENDIX PP INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi WEANLINGS 1465 ^"'^^^^noteontaInTSCACB, H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________DuPont-5386 INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi WEANLINGS EXPLANATORY NOTES Abbreviations SP = Sacrificed by design; necropsy performed 1466 Company Sanitized. Does not contain TSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIEUAL AiNIMAL GROSS OEISERVATIONS - Fi WEANLINGS ANIMAL NUMBER SS^SSSSSKXtx MALE I tATS DAYS ON TEST' FATE GROUP: I-:L DOSE: OBSEIiVATIONS 0 MG/KG/DAY 647081 647082 1 SP . 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 647083 647084 647085 647086 647087 647088 647089 647090 647091 647092 647093 647094 647095 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 1467 SanlB^.Dee.nrteontalnTSCAeBS Bonw H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ANIMAL NUMBER I MDIV:[DUAL JWIMAL GROSS OBSERVATIONS - Pi WEANLINGS MALE RATS DAYS ON TEST FATE GROUP: 1-1 DOSE 0 MG/KG/DAY OBSERVATIONS 647096 - 1 SP 647097 1 SP 647098 1 SP 647099 1 SP 647100 1 SP 647101 1 SP 647102 1 SP 647103 1 SP 647104 1 SP 647105 1 SP 647106 1 SP 647107 1 SP 647108 1 SP 647109 1 SP 647110 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 1468 inotemtainTSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ANIMAL NUMBER INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Pi WEANLINGS MALE RATS DAYS OM TEST FATE GROUP: 1-1 DOSE: 0 MG/KG/DAY OBSERVATIONS 647111 647112 647113 647114 647115 647116 647117 647118 647119 647120 647121 647122 1 . SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP N0 ABNORMALITIES DETECTED N0 ABNORMALITIES DETECTED N0 ABNORMALITIES DETECTED N0 ABNORMALITIES DETECTED N0 ABNORMALITIES DETECTED N0 ABNORMALITIES DETECTED N0 ABNORMALITIES DETECTED N0 ABNORMALITIES DETECTED N0 ABNORMALITIES DETECTED N0 ABNORMALITIES DETECTED N0 ABNORMALITIES DETECTED N0 ABNORMALITIES DETECTED DuPont-5386 1469 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ANIMAL NUMBER I]'.IDIVIDTJ[AL ANIMAL GROSS OB.SERVATIONS - Fi WEANLINGS W \IS RATs DAYS ON TEST FATE ==============s==s=== GROUP: III- 1 DOSE: 25 MG/KG/DAY OBSEIWATIONS 647139 647140 647141 647142 647143 647144 647145 647146 647147 647148 647149 647150 647151 647152 647153 647154 - 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP MO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED MO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED MO ABNORMALITIES DETECTED DuPont-5386 1470 I contain T8CACW H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ANIMAL NUMBER IMDIVII3UAL flMIMAL GROSS OB SERVATIONS - Fi WEANLINGS MALE R?^TS DAYS ON TES'T FATE GROUP: III-:1 DOSE: OBSEEOVATIONS 25 MG/KG/DAY 647155 1 . SP 647156 1 SP 647157 1 SP 647158 1 SP 647159 1 SP 647160 647161 647162 647163 647164 647165 647166 647167 647168 647169 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED KIDNEYS KIDMEYS - LARGE, LEFT SMALL, RIGHT; SEVERE NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 1471 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ANIMAL NUMBER INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi WEANLINGS MALE RATS DAYS ON TEST FATE GROUP: III-l DOSE: 25 MG/KG/DAY OBSERVATIONS =;===;=====:= 647170 647171 - 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 647172 1 SP NO ABNORMALITIES DETECTED 647173 1 SP NO ABNORMALITIES DETECTED 647174 1 SP NO ABNORMALITIES DETECTED 647175 1 SP NO ABNORMALITIES DETECTED 647176 1 SP NO ABNORMALITIES DETECTED 647177 1 SP NO ABNORMALITIES DETECTED 647178 1 SP NO ABNORMALITIES DETECTED 647179 1 SP NO ABNORMALITIES DETECTED 647180 1 SP NO ABNORMALITIES DETECTED 647181 1 SP NO ABNORMALITIES DETECTED 647182 1 SP NO ABNORMALITIES DETECTED 647183 1 SP NO ABNORMALITIES DETECTED DuPont-5386 1472 Company SanWzed. Does not confab TSCA OBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations rNDIVIl3UAL A;NIMAL GROSS OBiSERVATIONS - Pi WEANLINGS ANIMAL NUMBER ssissssssasss: MALE R ATS DAYS ON TEST' FATE GROUP: V-l DOSE: 100 MG/KG/DAY OBSEIWATIONS 647196 . 1 SP NO ABNORMALITIES DETECTED 647197 647198 647199 647200 647201 647202 647203 647204 647205 647206 647207 647208 647209 647210 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 1473 Company SanRized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDTOVL ANIMAL GROSS OBi3ERVATIONS - Pi WEANLINGS ANIMAL NUMBER MALE RATS DAYS OH TEST FATE :==::=:=::===SSSESSS ========---------------------- GROUP: V-l DOSE: OBSERVATIONS 100 MG/KG/DAY 647211 - 1 SP NO ABNORMALITIES DETECTED 647212 1 SP NO ABNORMALITIES DETECTED 647213 1 SP NO ABNORMALITIES DETECTED 647214 1 SP NO ABNORMALITIES DETECTED 647215 1 SP NO ABNORMALITIES DETECTED 647216 1 SP NO ABNORMALITIES DETECTED 647217 1 SP NO ABNORMALITIES DETECTED 647218 1 SP NO ABNORMALITIES DETECTED 647219 1 SP NO ABNORMALITIES DETECTED 647220 1 SP NO ABNORMALITIES DETECTED 647221 1 SP NO ABNORMALITIES DETECTED 647222 1 SP NO ABNORMALITIES DETECTED 647223 1 SP NO ABNORMALITIES DETECTED 647224 1 SP NO ABNORMALITIES DETECTED 647225 1 SP NO ABNORMALITIES DETECTED DuPont-5386 1474 ^'"'VwiySanHfeedD; oes not contain TSCA Bl H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ANIMAL NUMBER INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi WEANLINGS MALE RATS DAYS ON TEST FATE GROUP: V-l DOSE: 100 MG/KG/DAY OBSERVATIONS 647226 647227 647228 647229 SP NO ABNORMALITIES DETECTED SP NO ABNORMALITIES DETECTED SP NO ABNORMALITIES DETECTED SP NO ABNORMALITIES DETECTED DuPont-5386 1475 Company Ssnitfzo<JL Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ANIMAL NUMBER INDIVIE)UAL P.iNIMAL GROSS OBSERVATIONS - Fi WEANLINGS 11ALE RA'rs DAYS ON TES'I FATE GROUP: VII-3L DOSE: 250 MG/KG/DAY OBSEIWATIONS 647242 647243 647244 647245 647246 647247 647248 647249 647250 647251 647252 647253 647254 647255 647256 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 SP SP SP SP SP SP SP SP SP SP SP SP - SP SP SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES 'DETECTED NO ABNORMALITIES DETECTED DuPont-5386 1476 ^^^^eonfeR,,^,^ H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ANIMAL NUMBER ENDIVIEUAL A JSTIMAL GROSS OE1SERVATIONS - Fi WEANLINGS MALE RA1rs DAYS ON TEST FATE GROUP: VII-:L DOSE: 250 MG/KG/DAY OBSEIOVATIONS 647257 1 . SP 647258 1 SP 647259 1 SP 647260 1 SP 647261 1 SP 647262 1 SP 647263 1 SP 647264 1 SP 647265 1 SP 647266 1 SP 647267 1 SP 647268 1 SP 647269 1 SP 647270 1 SP 647271 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 1477 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ANIMAL NUMBER INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi WEANLINGS MALE RATS DAYS ON TEST FATE GROUP: VII-1 DOSE: 250 MG/KG/DAY OBSERVATIONS 647272 647273 647274 647275 647276 SP NO ABNORMALITIES DETECTED SP NO ABNORMALITIES DETECTED SP NO ABNORMALITIES DETECTED SP NO ABNORMALITIES DETECTED SP NO ABNORMALITIES DETECTED DuPont-5386 1478 Company Sariteed. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ANIMAL NUMBER [NDIVir3UAL A NIMAL GROSS OBSERVATIONS - Fi WEANLINGS I 'EMALE RATS DAYS ON TEST PATE =S=:55:S=:S=:ssssssssss GROUP: II -1 DOSE: OBSEIWATIONS 0 MG/KG/DAY 647290 1 . SP NO ABNORMALITIES DETECTED 647291 647292 647293 647294 647295 647296 647297 647298 647299 647300 647301 647302 647303 647304 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 1479 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ANIMAL NUMBER INDIVII)UAL AJMIMAL GROSS OB SERVATIONS - I i'l WEANLINGS FEMALE RATS DAYS ON TEST FATE =:=======;= GROUP: II -1 DOSE: 0 MG/KG/DAY OBSEIWATIONS 647305 - 1 SP 647306 1 SP 647307 1 SE> 647308 1 SP 647309 1 SP 647310 1 SP 647311 1 SP 647312 1 SP 647313 1 SP 647314 1 SP 647315 1 SP 647316 1 SP 647317 1 SP 647318 1 SP 647319 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 1480 fcompanySanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ANIMAL NUMBER INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi WEANLINGS FEMALE RATS DAYS ON TEST FATE GROUP: II-1 DOSE: 0 MG/KG/DAY OBSERVATIONS 647320 647321 647322 647323 647324 647325 SP NO ABNORMALITIES DETECTED SP 'NO ABNORMALITIES DETECTED SP NO ABNORMALITIES DETECTED SP NO ABNORMALITIES DETECTED SP NO ABNORMALITIES DETECTED SP NO ABNORMALITIES DETECTED DuPont-5386 1481 Company Sanitized. Does not contain TCCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study m Rats with One-Generation Reproductive Evaluations ANIMAL NUMBER INDIV:IDUAL i'UTIMAL GROSS 013SERVATIONS - Fi WEANLINGS F'EMALE RATS DAYS 'ON TES1' FATE GROUP: IV -1 DOSE: 25 MG/KG/DAY OBSE RVATIOMS 647343 647344 647345 647346 647347 647348 647349 647350 647351 647352 647353 647354 647355 647356 647357 647358 1 - SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 1482 Company Sanitized. Does not contain TSCA CBj H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ANIMAL NUMBER I]TOIV:[DUAL 1ANIMAL GROSS OBSERVATIONS - PI WEAKLINGS FEMALE RATS DAYS ON TEST FATE GROUP: IV-1 DOSE: 25 MG/KG/DAY OBSERVATIONS 647359 - 1 SP 647360 1 SP 647361 1 SP 647362 1 SP 647363 1 SP 647364 1 SP 647365 1 SP 647366 1 SP 647367 1 SP 647368 1 SP 647369 1 SP 647370 1 SP 647371 1 SP 647372 1 SP 647373 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED MO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 1483 Company Sanitized. Does noi contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Sfady in Rats with One-Generadon Reproductive Evaluations INDIVIDUAL AMIMAL GROSS 0]3SERVATIOMS - Pi WEAMLIMGS ANIMAL NUMBER ===;=;=;====:= FEMALE RATS DAYS ON TEST PATE ,, GROUP: IV -1 DOSE: OBSE RVATIOMS =:=:==;S ===:===:=:=:===;= 25 MG/KG/DAY 647374 1 . SP MO ABMORMALITIES DETECTED 647375 1 SP MO ABMORMALITIES DETECTED 647376 1 SP N0 ABNORMALITIES DETECTED 647377 1 SP MO ABMORMALITIES DETECTED 647378 1 SP MO ABMORMALITIES DETECTED 647379 1 SP N0 ABMORMALITIES DETECTED 647380 1 SP N0 ABMORMALITIES DETECTED 647381 1 SP MO ABMORMALITIES DETECTED 647382 1 SP MO ABMORMALITIES DETECTED 647383 1 SP MO ABMORMALITIES DETECTED 647384 1 SP MO ABMORMALITIES DETECTED 647385 1 SP MO ABMORMALITIES DETECTED 647386 1 SP MO ABMORMALITIES DETECTED 647387 1 SP MO ABMORMALITIES DETECTED 647388 1 SP MO ABMORMALITIES DETECTED DuPont-5386 1484 Company Sanded. Does not contain TBCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi WEANLINGS ANIMAL NUMBER FEMALE RATS DAYS ON TEST FATE = = == St SS ==;= S3: = = = = = S= S= =E1==S S S= =; GROUP: IV-1 DOSE: 25 MG/KG/DAY OBSERVATIONS 647389 - 1 SP 647390 1 SP 647391 1 SP 647392 1 SP 647393 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 1485 nolcontateTSCACBI Company Sanitized. Does H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ANIMAL NUMBER INDIVII)UAL AMIMAL GROSS OE(SERVATIONS - Fi WEANLINGS F33MALE SIATS DAYS ON TEST FATE GROUP: VI- 1 DOSE: OBSE]XVATIOMS 100 MG/KG/DAY DuPont-5386 647406 . 1 SP 647407 647408 1 SP 1 SP 647409 1 SP 647410 647411 647412 1 SP 1 SP 1 SP 647413 647414 1 SP 1 SP 647415 1 SP 647416 647417 647418 647419 647420 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED 'NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED MO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 1486 Company SanWzed. Does not contain TSCA CBt H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ANIMAL NUMBER 11sroiv:IDUAL 1MIIMAL GROSS OBSERVATIONS - FI WEANLINGS FETIALE RATS DAYS ON TEST FAT'E SSSiSSSS GROUP: VI-1 DOSE: 100 MG/KG/DAY OBSERVATIONS 647421 - 1 SP 647422 1 SP 647423 1 SP 647424 1 SP 647425 1 SP 647426 1 SP 647427 1 SP 647428 1 SP 647429 1 SP 647430 1 SP 647431 1 SP 647432 1 SP 647433 1 SP 647434 1 SP 647435 1 SP MO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 1487 ampahy Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ANIMAL NUMBER INDIVIE1UAL P.iNIMAL GROSS 0]3SERVATIONS - Fi WEANLINGS FEMALE RATS D.AYS ON TES"!C FATE =5=========:: GROUP: VII]C-l DOSE: 250 MG/KG/DAY OBSE RVATIONS 647448 647449 647450 647451 647452 647453 647454 647455 647456 647457 647458 647459 647460 647461 647462 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED MO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 1488 Qe/SHpsay Sanitized. Does not contain TSCA CBI H-24516: SubchromcToxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ANIMAL NUMBER IN13IVIDUAL ANIMAL GROSS OB SERVATIONS - 1?i WEIANLINGS FEMAIjE RATS DAYS OH TEST PATE GROUP: VIII -1 DOSE: 250 MG/KG/DAY OBSEIWATIONS DuPont-5386 647463 1 - SP 647464 1 SP 647465 1 SP 647466 1 SP 647467 1 SP 647468 1 SP 647469 1 SP 647470 1 SP 647471 1 SP 647472 1 SP 647473 1 SP 647474 1 SP 647475 1 SP 647476 1 SP 647477 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 1489 eompany SanHteed. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ANIMAL NUMBER INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Pi WEANLINGS FEMALE RATS DAYS ON TEST FATE GROUP: VIII-1 DOSE: OBSERVATIONS 250 MG/KG/DAY DuPont-5386 647478 647479 647480 647481 647482 647483 647484 SP NO ABNORMALITIES DETECTED SP NO ABNORMALITIES DETECTED SP NO ABNORMALITIES DETECTED SP NO ABNORMALITIES DETECTED SP NO ABNORMALITIES DETECTED SP NO ABNORMALITIES DETECTED SP NO ABNORMALITIES DETECTED 1490 Company Sanitized. Does not (iontain TSCA CBI APPENDIX QQ INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi ADULTS Company Sanitized. Does not contain TSCACBI INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi ADULTS EXPLANATORY NOTES Abbreviations SD = Sacrificed by design 1492 ompany SanMIzed. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ANIMAL NUMBER INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi ADULTS MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY DAYS MODE OF ON TEST DEATH OBSERVATIONS 647068 647069 647070 647071 647072 647073 647074 647075 647076 647077 647078 647079 647080 40 SD NO ABNORMALITIES DETECTED 40 SD KIDNEYS - DILATATION, BILATERAL, PELVIS 40 SD NO ABNORMALITIES DETECTED 40 SD NO ABNORMALITIES DETECTED 40 SD NO ABNORMALITIES DETECTED 40 SD NO ABNORMALITIES DETECTED 40 SD NO ABNORMALITIES DETECTED 40 SD .NO ABNORMALITIES DETECTED 40 SD NO ABNORMALITIES DETECTED 40 SD NO ABNORMALITIES DETECTED 40 SD MO ABNORMALITIES DETECTED 40 SD NO ABNORMALITIES DETECTED 40 SD NO ABNORMALITIES DETECTED DuPont-5386 1493 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ANIMAL NUMBER INDIVIDTJAL ANIMAL GROSS OBSERVATIONS - Pi ADULTS MALE RATS DAYS (3N TEE;T ==;===;=== MODE OF DEATH GROUP: III-l DOSE: 25 MG/KG/DAY OBSERVATIONS 647123 647124 647125 647126 647127 647128 647129 647130 647131 647132 647133 647134 647135 647136 647137 647138 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD -40 SD 40 SD 40 SD 40 SD NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED .NO ABNORMALITIES DETECTED KIDNEYS - DILATATION, RIGHT, PELVIS NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED KIDNEYS - DILATATION, UNILATE;RAL, PELVIS NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED KIDNEYS - DILATATION, RIGHT, PELVIS DuPont-5386 1494 Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ANIMAL NUMBER INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi ADULTS MALE RATS . GROUP: V-l DOSE: 100 MG/KG/DAY DAYS MODE OF ON TEST DEATH OBSERVATIONS DuPont-5386 647184 647185 647186 647187 647188 647189 647190 647191 647192 647193 647194 647195 40 3D 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD NO ABNORMALITIES DETECTED KIDNEYS - DILATATION, RIGHT, PELVIS KIDNEYS - DILATATION, RIGHT, PELVIS KIDNEYS - DILATATION, RIGHT, PELVIS NO ABNORMALITIES DETECTED KIDNEYS - DILATATION, UNILATERAL, MINIMAL, PELVIS MO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED KIDNEYS - DILATATION, RIGHT, PELVIS KIDNEYS - DILATATION, RIGHT, PELVIS NO ABNORMALITIES DETECTED 1495 Company Sanitized. Does not contain TSCA CBi H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi ADULTS MALE RATS ANIMAL NUMBER DAYS MODE OF ON TEST DEATH ===^====!==:===:S:;=:==!SS:===: GROUP: VI I-1 DOSE: 250 MG/KG/DAY OBSERVATIONS 647230 40 SD -NO ABNORMALITIES DETECTED 647231 40 SD N0 ABNORMALITIES DETECTED 647232 40 SD N0 ABNORMALITIES DETECTED 647233 40 SD N0 ABNORMALITIES DETECTED 647234 40 SD N0 ABNORMALITIES DETECTED 647235 40 SD N0 ABNORMALITIES DETECTED 647236 40 SD N0 ABNORMALITIES DETECTED 647237 40 SD . N0 ABNORMALITIES DETECTED 647238 40 SD N0 ABNORMALITIES DETECTED 647239 40 SD N0 ABNORMALITIES DETECTED 647240 40 SD N0 ABNORMALITIES DETECTED 647241 40 SD N0 ABNORMALITIES DETECTED DuPont-5386 1496 Gomoaw Sanded. Does not contain TCCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ANIMAL NUMBER INDIVIDUAL .ANIMAL GROSS OBSERVATIONS - Fi ADULTS FEMALE RATS DAYS ON TEST MODE OF DEATH SSSSSSS GROUP: II-l DOSE: 0 MG/KG/DAY OBSERVATIONS 647277 647278 647279 647280 40 SD 40 SD 40 SD 40 SD N0 ABNORMALITIES DETECTED N0 ABNORMALITIES DETECTED N0 ABNORMALITIES DETECTED N0 ABNORMALITIES DETECTED 647281 647282 647283 647284 647285 647286 647287 647288 647289 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD N0 ABNORMALITIES DETECTED N0 ABNORMALITIES DETECTED N0 ABNORMALITIES DETECTED N0 ABNORMALITIES DETECTED N0 ABNORMALITIES DETECTED N0 ABNORMALITIES DETECTED N0 ABNORMALITIES DETECTED N0 ABNORMALITIES DETECTED N0 ABNORMALITIES DETECTED DuPont-5386 1497 Company Sanitized. Does a eonlate TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ANIMAL NUMBER INDI'V'IDUAL ANIMAL GROSS ()BSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-.1 DOSE: 25 MG/KG/DAY DAYS MODE OF ON TES'T DEATH OBSEIS.VATIONS 647326 40 SD NO ABNORMALITIES DETECTED 647327 40 SD NO ABNORMALITIES DETECTED 647328 40 SD NO ABNORMALITIES DETECTED 647329 40 SD NO ABNORMALITIES DETECTED 647330 40 SD NO ABNORMALITIES DETECTED 647331 40 SD NO ABNORMALITIES DETECTED 647332 40 SD NO ABNORMALITIES DETECTED 647333 40 SD . NO ABNORMALITIES DETECTED 647334 40 SD NO ABNORMALITIES DETECTED 647335 40 SD NO ABNORMALITIES DETECTED 647336 40 SD NO ABNORMALITIES DETECTED 647337 - 40 SD NO ABNORMALITIES DETECTED 647338 40 SD NO ABNORMALITIES DETECTED 647339 40 SD NO ABNORMALITIES DETECTED 647340 40 SD NO ABNORMALITIES DETECTED 647341 40 SD NO ABNORMALITIES DETECTED 647342 40 SD NO ABNORMALITIES DETECTED DuPont-5386 1498 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ANIMAL NUMBER INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi ADULTS FEMALE RATS GROUP: VI-1 DOSE: 100 MG/KG/DAY DAYS MODE OF ON TEST DEATH OBSERVATIONS DuPont-5386 647394 647395 647396 647397 647398 647399 647400 647401 647402 647403 647404 647-405 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED KIDNEYS - DILATATION, UNILATERAL, PELVIS KIDNEYS - DILATATION, RIGHT, PELVIS NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 1499 eonwwSanW^d.Doe."^^'1"^^68' H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - P^ ADULTS FEMALE RATS ANIMAL NUMBER DAYS MODE OF ON TEST DEATH GROUP: VIII-1 DOSE: 250 MG/KG/DAY OBSERVATIONS =:==:======;=:;=;=: as ==s=s==s=== 647436 40 SD N0 ABNORMALITIES DETECTED 647437 40 SD N0 ABNORMALITIES DETECTED 647438 40 SD N0 ABNORMALITIES DETECTED 647439 40 SD N0 ABNORMALITIES DETECTED 647440 40 SD N0 ABNORMALITIES DETECTED 647441 40 SD N0 ABNORMALITIES DETECTED 647442 40 SD N0 ABNORMALITIES DETECTED 647443 40 SD N0 ABNORMALITIES DETECTED 647444 40 SD N0 ABNORMALITIES DETECTED 647445 40 SD N0 ABNORMALITIES DETECTED 647446 40 SD N0 ABNORMALITIES DETECTED 647447 40 SD N0 ABNORMALITIES DETECTED DuPont-5386 1500 Company Sanitized. Does not contain TSCA CBI