Document KRyY63Mxr53wM4Kp2M7YrGM70

OCT 1 1 2005 15:42 FR C1ST1 ICIST 613 952 9303 TO 12145201181 352 CHRYSOTILE ASBESTOS--LANGER ET AL Table 1 .--Epidemiological Data on 28 Studied Cases Case Age 1 66 2 70 3 45 Sex F M M Occupation Domestic Truck driver Home repairs Cause of Death Polycystic kidneys Lung cancer Glomerulonephritis 4 82 M Tailor 5 80 M Linen supplier 6 53 M Bartender 7 75 M Porter, office 8 27 M Computer operator 9 46 M Appliance factory 10 48 M Plumber 11 61 M Attorney 12 77 M Lens polisher 13 81 M Tailor Arteriosclerotic heart disease Colon cancer Hypernephroma Hypertension Melanoma, eye Sepsis Chronic glomerulo nephritis Reticulum cell sarcoma Pancreatic cancer Pancreatic cancer 14 50 F IS 48 F 16 61 F 17 68 M 18 80 F 19 42 F 20 59 F 21 79 F 22 58 F 23 76 F 24 75 F 8roker Housewife Housewife Chauffeur Office secretary Grocery clerk Bookkeeper Housewife Stenographer Housewife Seamstress Myocardial infarction Myocardial infarction Lung cancer Heart block Myocardial infarction Cirrhosis of the liver Myeloid metaplasia Bronchopneumonia Stroke Myocardial infarction Glomerulonephritis 25 45 M Musician 26 72 M Salesman 27 64 F Housewife 28 76 M Dress manufacturer * NA, not available. Aortic Insufficiency Metastatic carcinoma, primary site not determined Cryptococcal meningo encephalitis Myocardial infarction Asbestos Exposure Comments 0 Used asbestos ironing pads 0 Some used Lived near shipyard in repairs 0 0 0 0 0 0 Material in trade 0 0 0 NA* 0 0 0 0 0 0 NA* 0 0 0 0 0 Asbestos ironing board covers Construction laborer, 1940"s . .. . .. Oil burner repairs .., Home repairs, asbestos cement Asbestos ironing board covers,lived near shipyard ... ..* ... ... ... Asbestos Ironing board covers Riveter, WWII; asbestos gloves .. Asbestos ironing board covers ... Once lived near yard with building materials ... ... 0 Asbestos ironing board covers 0 microscopic methods. This was determined by comparison of light microscopic samples with the same material studied by electron microscopy. Asbestos and Asbestos Bodies.--Thus, 'sev eral considerations explain the difficulty of demonstrating chrysotile asbestos in human lung tissue if one is limited to those particles visible by optical microscopy: (1) Chrysotile tends to break into fine fibrils, often smaller in diameter than 0.5/*, the limit of resolution of the light microscope, and so not visible by this instrument. (2) It may be inhaled as fibrils or fibers; the latter, once inhaled, may separate into the unit fibrils and thus be come "invisible." (3) Chrysotile's chemical and physical nature makes it subject to attack in tissue fluids, in contrast to amphibole asbestos. These factors make for "survivor populations" of the latter when fibers are extracted from human lung. All in all, with out the electron^ microscope, one must feel insecure when searching for chrysotile asbes tos in lung tissue, and techniques based upon light optical microscopy are studded with pitfalls. In summary, chrysotile asbestos is unlike ly to remain as large fiber bundles in man. "Asbestos bodies" in man, that are easily visible in the light microscopic size range, are not likely to be chrysotile nucleated or, if so nucleated, not to be unaltered chrysotile. If I ! ! Arch Environ Health--Vol 22, March 1971 RECEIVED TIME OCT. 11. 2:43PM