Document KRZK14jbm9OV7vkzYzyape2jo

Copies AR226-2751 E. I. du Pone de Neniours and Company ' Haskell Laboratory for Toxicology anil Industrial Medicine Elkton Road, Newark, Delaware 19711 HASKELL LABORATORY KEPORT NO. 635-79 Material Tested Octanoic Acid, Pzntadecafluoro-, Ammonium Salt* Haskell No. 12,037 Other Codes Study Initiated/ Completed 8/13-9/11/79 ' -- <Mace r t e Department, W EYE IRRITATION TEST IM RABBITS Procedure; One-tenth' railliliter (38.3 Dug) of solid test material was placed into the right conju albino rabbits. After 20 seconds, 1 created eye was washed with tap water for 1 minute. The tre rabbit was not washed. Observations of the cornea, iris and conjunctiva were made with a ha '-sl and at 1, 2, 3, 7, 14, 21 and 28 days; Fluor-i- strip stain and a biomicroscope were used at exam Lreataent. Results: Uosfc Treatment of Eyes Cornea Ocular Effects Tris U.I nil (Jy.'J mg) aulld test iiiulerial Not Washed Generalized moderate opacity 1 Slight Injection at. 4 R hour-3 days. At 2 days, a hours. Moderate conges M small area in tlie lower cornea tion at 1 day. Slight a had severe opacity. The opa Injection at 2 days. S city gradually receded to Moderate congestion at M generalized mild at 7 days 14 days. 1 excepl or the area in the d lower ^ornea which had moderate opacity with vascularization. D This arci of opacity persisted a through 14 days but gradually 2 receded in size and degree to p localized mild opacity with a vascularization 21-28 days, Company Sanitized. Doss - 2 Results: (continued Dose Treatment of Eyes 0.1 ml (3B.3 nig) solid teat Diuleridl Mashed Cornea Small area of mild opacity ac Ocular Effects Iris None. Red day Sw day Dis hou (He 1 d ' ^ p r t - Summary; Octunolc Acid, Pentadecafluoro-, Ammonium SaltljH^^B|caused generalized'moderate corn area of severe opacity, intermittent moderate iritis andd"^mBooddeerartaetecconjunctivitis when tested in a effects gradually receded; however, the small area of corneal opacity persisted and at 21-28 days zaclon (sign of healing). An eye dosed with the test material and promptly washed had u small are corneal opacity and moderate to slight: conjunctivitis with no irjitic effect. The eye was normal w mild conjuiiccival redness, which was normal within 14 days. fwA a mild to moderate eye Irritant, capable of causing persistent mild corneal o with tillLss comppoeul nd a liould be avoided. In the event of any eye contact, flush copiously with wate attention. ''' Oilier Names: Cuinpjsit.ion: WV.:GCti K(.-puri No. 635-79 ,P^tfc lyaucd; October .5., 1979 Report by: Approved by: ^/o-Ur } <f(. Dori To . \' i i >--'. Gera Chief, Acute Company Sani^zcri. Doss m