Document KRLxxZmJ3yNoDrB6RemrvL6BX

FILE NAME: Abex (ABX) DATE: 1936 Nov 20 DOC#: ABX067 DOCUMENT DESCRIPTION: Letter from Vandiver Brown, General Attorney to the Director of The Saranac Laboratory Castleman File: ABEX Q ~7 w/c = with cover letter or memo If DATE = 0, undated CD-ROM Document #:abex DATE (Q ~Z, _ published article from trade journal __ published advertisement from trade journal __ government inspection results ,__ unpublished or internal report __ unpublished presentation from conference ynewspaper article __ letter __ memorandum __ industry warning labels __ industry sales literature __ industry recommended practices __ meeting agenda __ minutes __ attendee list __ legal filing of defense __ legal filing of plaintiff __ legal deposition O R __ legal testimony of; __ legal deposition summary / index ) Hovaraber 20, 1936 LeRoy U. Gardner, II, D., Director, The Saranac Laboratory, Saranac Lake, He York. Dear Dr. Gardner! *v At a meeting yesterday attended by certain brass lining manufacturers, Mr. Simpson and I ere able to present to a fairly large group of Interested corporations the proposal that one of your dusting chambers be engaged for further experi mentation with asbestos dust. the proposal was very well, received and it appears that not less than eight, and perhaps ten or more, corporations will participate in financing these further experiments along the lines discussed when we met with Dr. Lanza and Dr. McConnell a few days ago. Accordingly, you may consider this 'letter as an authorisation to you to commence the contemplated experiments with asbestos dust for the purpose of determining more definitely the causes and effects of asbestosis. It is my understanding that, among other questions which it is anticipated these experi ments will answer, are the following! (1) What concentration of dust is necessary to prouuce the fibrosis of the lungs which is designated as asbestosis. . (2) Whether exposure to asbestos dust will produce asbestosis without the existence of previous infection and whether the X-ray changes found in advanced human asbestosis can be reproduced in animals without infection. (3) Whether the fibrosis produced by asbestos is * of the progressive type, that is, will the fibrosis Increase (once It has started) after exposure to the dust ha3 ceased. 004-737 f r s ` SPNY 000461  2- (4) Whether the fibrosis resulting from exposure to r atsebnetstoofs tdhuestasbisestoocscasorionbeyditbsy fthiebrosuislicsotnrucctounre. (5) Whether the presence of *asbestos bodies* has any diagnostic significance. It is also our understanding that these experiments will require approximately three years, which will scan that they will not be concluded until about the end of the year 1939; and that they will cost ?5000 annually, or a total, of $15,000. It is our further understanding that the results obtained will be considered the property of those who are advanc ing the required funds, who will determine whether, to what extent and in what manner they shall be made public. In the event it is deemed desirable that the results be made public, the manuscript of your study will be submitted to us for approval prior to publica tion. I shall appreciate your advising me if the foregoing accurately expresses the proposition you had in mind. Also, let me know the manner in which you would like to have the funds ad vanced to you. Would you, for example, desire to have $1250 paid quarterly in advance, or just what arrangement would suit you best? Any method you suggest will be satisfactory. ' < Since the experiments are being underwritten by a rela tively large group, it has been suggested that, as a matter of con venience, any communications regarding the work be addressed to me and I will, where necessary, communicate the contents thereof to Mr. Simpson and the other parties. You will be provided with funds by either Johns-Manville Corporation or Raybestos-Manhattan, Incor porated and we or tney will secure from the other parties their pro rata contribution. -- I4--mmmmm `mmmmtm-- mam I will advise you later of the names of the other con tributing parties. , I shall appreciate your informing me at the earliest possible moment whether the arrangement as outlined herein meets with your approval. Y3:T a . Sincerely yours, Vandiver Broowwin General Attorney 004738 SPNY 000462