Document KR1MJrk0RgQ3rGbL8pr40NGrN

PAGE 341 MAR 1 6 1983 ** *************************************************************** ************************************************************ CHEMICAL ABSTRACTS SERVICE ********* INDIVIDUAL SEARCH SERVICE CHEMICAL ABSTRACTS SERVICE ********* INDIVIDUAL SEARCH SERVICE PROFILE ID 12217F HERE ARE THE RESULTS OF YOUR PERSONAL SEARCH OF VOLUME 98 ISSUES 9-10 OF THE CHEMICAL ABSTRACTS SERVICE INFORMATION BASE J. H. Craddock - A3SA PolychlorInated Biphenyls These search results Include additions, revisions, and deletions to your profiles since the previous .ISS production run. Please review each added or revised search query as soon as you can to verify that It reflects your desired search strategy. Please make any substantive revisions to your search query by using a Profile Transaction Form. Minor changes may be made by marking a photocopy of the search query and attaching it to a Profile Transaction Form. Minor changes may also be made by telephone. Please submit all written profile revisions to CAS at: MR TOMMY EBE CDIS/ISS 067 PO BOX 02288 COLUMBUS OH 43202 For minor revisions and questions profiles, please call CAS at: concerning your . (614) 421-3673 CHEMICAL ABSTRACTS SERVICE ********* INDIVIDUAL SEARCH SERVICE CHEMICAL ABSTRACTS SERVICE ****** INDIVIDUAL SEARCH SERVICE / PCB-ARCH-EXT0378213 PROFILE 10 12217F QUERY NUMBER 001 CA98(9) :66468P Journal CASCT CA104000 HITS. PCB* Environmental toxicology of PCB substitutes for capacitors. Sapersteln, Mark D.; Faeder, Edward J. (South. California Edison Co., Rosemead, CA 91770 USA). Regut. Toxicol. Pharmacol. (RTOPDW] 1982, 2(3), 238-46 (Eng). A review and discussion with 13 refs. review PCB substitute capacitor toxicity environment PCB substitute capacitor review COPYRIGHT 1983 BY THE AMERICAN CHEMICAL SOCIETY PAGE 342 PROFILE ID 12217F QUERY NUMBER 001 CA98(9):66520Z Journal CASCT CA10400O HITS: PCB* Relationship of structure to accumulation In liver of PCB Isomers. Kawanlshl, Shosuke: Sekl, Yoshlhlko; Sano, Selyo (Fac. Med., Kyoto Unlv., Kyoto, Japan 606). Salshln Igaku (SAIGAK) 1982, 37(12), 2384-7 (Japan). A review with 19 refs. review PCB metab 1Iver structure COPYRIGHT 1983 BY THE AMERICAN CHEMICAL SOCIETY I PROFILE ID 12217F QUERY NUMBER OOI CA98(9):66517D Journal CASCT CA104000 HITS: PCB* . Biological effects of PCB and related polychlorinated compounds. Kuntta. Nobuharu; Kashimoto, Takashl (Osaka Pref. Inst. Pub. Health, Osaka, Japan 538). Salshln Igaku [SAIGAK] 1982, 37(12), 2378-83 (Japan). A review with 18 refs, on the tissue levels of PCB In man, monkey, and rat exposed to Yusho causative oil and PCB. review PCB me tab polychlorinated compd metab review COPYRIGHT 1983 BY THE AMERICAN CHEMICAL SOCIETY f PROFILE ID 122 17F QUERY NUMBER 001 CA98(9):66546N Journal CASCT CA104001 HITS: PCB*, *CHL0R* Minimization of blank values of the miniature silica gel column. Plcer, Nena;P1cer, Mladen; Mlkac, Nevenka (Cent. Mar. Res. Zagreb, "Rudjer Boskovlc" Inst., Zagreb. Yugoslavia). Chemosphere (CMSHAF) 1982, 11(9), 825-32 (Eng). A system of solvent and silica gel of the lowest blank values for the sepn. of PCBs from chlorinated Insecticides was developed. PCBs elution was performed with pentane, while the chlorinated Insecticides eluated with Et20, acetone, MeOH, and benzene. The elution of pesticides (DDT (50-29-3). p,p'-DDE (72-55-9). p, p'-TDE (72-54-8), dleldrin (I) (60-57-1)) gave the best results for the following solvent systems: Et20 + hexane (1:1), acetone * hexane (1:4), MeOH + pentane (1:8) and benzene. Sepn. of pesticides from PCB's found In a synthetic mlxt. was also examd. All solvent systems used gave similar results of sepn. However, only If benzene Is used as eluent, the silica gel column can be used for 4 successive sepns. after the on column regeneration. To obtain the lowest blank values, silica gel was cleaned with several solvents. The eluates after the silica gel sepn. were also cleaned up by means of deactivation alumina and coned. H2S04.. (This abstract has a structure In the CA Issue.) ABSTRACT CONTINUED COPYRIGHT 1983 BY THE AMERICAN CHEMICAL SOCIETY PCB-ARCH-EXT0378214 CA98<9) :66546N chlorinated Insecticide PCB silica gel chromatog COPYRIGHT 1983 BY THE AMERICAN CHEMICAL SOCIETY 1 PAGE 343 CA98(9):66624M still .apprx.1% of the dose. Unchanged 6-CB predominated In feces, whereas urine contained polar metabolites only. During the fasting period, the 6-CB released from adipose tissue (46 of the 47% of the dose stored at the beginning of the fasting period) appeared In skin (29-55%) and In the fecal excretion (5-36%). Thus, the apparently Irreversibly stored 6-CB In adipose tissue of normal rats can be released by decreasing this storage or deep compartment. In the absence of adipose tissue, skin takes over the characteristics of an alternative storage compartment. / (This abstract has a structure In the CA Issue.) chi orobiphenyl pharmacokinetics biphenyl chloro metab food restriction COPYRIGHT 1983 BY THE AMERICAN CHEMICAL SOCIETY PROFILE 10 12217F QUERY NUMBER 001 CA9B(9):66624M Journal CASCT CA104003 HITS: `CHLOR*, `CHLOR* `BIPHENYL* /WORD Pharmacokinetics of 2,2',4,4',5,S'-hexach1orob1phenyl (0-CB) In rats with decreasing adipose tissue mass. I. Effects of restricting food Intake two weeks after administration of 8-CB. Wyss, P. A.; Muehlebach. S.; Blckel, M. H. (Dep. Pharmacol., Unlv. Berne, CH-3010 Bern, Swltz). Drug Metab. Dlspos. [DMDSAI] 1982, 10(6), 657-61 (Eng). The tissue distribution and excretion of 2,2'.4,4',5, 5'-hexachloroblphenyl (6-CB)(I) [35065-27-1] was studied In rats with decreasing adipose tissue mass. Single doses of 6-CB (0.6 mg/kg, l.v.) were administered to adult rat3 on an ad libitum diet, and 2 wk later their food Intake was restricted to 25% of the original dally Intake for an addnl. 6 wk. Body wts. decreased up to the 4th wk of fasting by .apprx.1/2 before they became stabilized when adipose tissues had almost disappeared. In the liver, lung, brain, skeletal muscle, and blood, 6-CB concns. Increased up to the 4th wk of fasting and then decreased with half-lives of 8-13 days. In contrast, the concn. did not decrease In skin throughout the fasting period, and the decrease in adipose tissue concn. was not preceded by an Increase. During the fasting period, cumulative fecal excretion Increased 10-fold as compared with control animals fed ad libitum. Urinary excretion was slightly enhanced but ABSTRACT CONTINUED COPYRIGHT 1983 BY THE AMERICAN CHEMICAL SOCIETY PROFILE 10 12217F QUERY NUMBER 001 CA98(9):66627Q Journal CASCT CA104003 HITS: *CHL0R*, *CHL0R` `BIPHENYL* /WORD Enhancement of sulfanilamide N4-hydroxylase activity In kidney and liver mlcrosomes of rats by pretreatment with 3-methylcholanthrene type-polychlorinated biphenyl. Eyanagl, Relko; Shlgematsu, Hldenari; Yoshlda, Kazuo; Yoshlmura. Hldetoshl (Daltchl Coll. Pharm. Scl., Fukuoka, Japan 815). J. Pharmacoblo-Dyn. [JOPHDQ] 1982, 5(11), 853-8 (Eng). N4-HydroxylatIon of sulfanilamide (I) [63-74-1] was studied with kidney and liver mlcrosomes of rats by means of high-performance ltq. chromatog. In kidney mlcrosomes, both contents of cytochrome P 450 [9035-51-2] (448 [9035-50-1]) and activity of sulfanilamide N4-hydroxylase (II) [84419-08-9] were Increased by pretreatment with 3,4,5,3', 4'-pentachloroblphenyl (PenCB) [57465-28-8] (.apprx.4 times), although neither was Increased by 3-methylcholanthrene (3-ME) [56-49-5] and phenobarbltal (PB) [50-06-6] pretreatments. In liver mlcrosomes, on the other hand, both II activity and cytochrome P 450 (448) contents were Increased by either PenCB or 3-MC pretreatment, whereas by PB pretreatment, II activity was not changed although cytochrome P 450 contents was Increased 2-fold. (This abstract has a structure In the CA Issue.) ABSTRACT CONTINUED COPYRIGHT 1983 BY THE AMERICAN CHEMICAL SOCIETY PCB-ARCH-EXT0378215 CA98(9 ) :666270 sulfanilamide hydroxylatIon kidney liver hydroxylase kidney liver sulfanilamide PCB sulfanilamide hydroxylase liver kidney methyIcholanthrene sulfanilamide hydroxylase liver kidney COPYRIGHT 1983 BY THE AMERICAN CHEMICAL SOCIETY PAGE 344 CA98(9):66862N the high-dose group was significantly higher than that in the controls. The hemanglosarcoma seen In female . mice were quite rare with only 6/816 (0.7%) previously seen In controls at the same lab. and .ltoreq.3 In any group of 50. Hemanglosarcoma also occurred In male mice with a significant pos. trend, with Incidences of 0/50 (0%), 2/50 (4%), and 3/50 (6%) In control, low-dose, and high-dose groups, resp. The development of hemanglosarcoma in the high-dose male mice might have been curtailed by the significantly reduced survival time In this group. (This abstract has a structure In the CA Issue.) blphenylamlne hydrochloride carcinogenicity COPYRIGHT 1983 BY THE AMERICAN CHEMICAL SOCIETY PROFILE 10 12217F QUERY NUMBER 001 CA98(9):66862N Journal CASCT CA104006 HITS: *CHL0R*, BIPHENYL* Carcinogenesis bioassay In rats and mice fed diets containing 2-blphenylamtne hydrochloride. Abdo, Kamai M.; Murthy. A. S. K.; Haseman, Joseph K.; Dieter, Michael P.: HiIderbrandt, P.: Huff, J. E. (Natl. Toxicol. Program, Natl. Environ. Health- Sci., Research Triangle Park, NC 27709 USA). Fundam. Appl. Toxicol. [FAATDF ] 1982, 2(5), 201-10 (Eng). Diets contg. 0.1-0.3% 2-blphenylamlne-HCl (I) [2185-92-4] were fed to groups of 50 rats and 50 mice of each sex for 104-106 wk. Mean body wts. of high-dose rats of both sexes and of low-dose male rats were slightly lower than those of controls. No significant differences In survival times were obsd. between dosed and control groups. In dosed male rats, there was a compd.-related Increased Incidence of kidneys with Inflammatory cells and Interstitial fibrosis. No tumors In dosed rats were assocd. with the chem. Mean body wts. of high-dose male mice were slightly lower than those of controls, and survival of high-dose male mice was also significantly reduced relative to controls. Hemanglosarcoma of the circulatory system occurred In female mice with a significant pos. trend. The obsd. Incidences of. hemanglosarcoma were 0/49 (0%), 1/50 (20%), and 7/50 (14%) In controls, low-, and high-dose groups, resp. In Individual group comparisons, the Incidence In ABSTRACT CONTINUED COPYRIGHT 1983 BY THE AMERICAN CHEMICAL SOCIETY PROFILE ID 12217F QUERY NUMBER 001 CA98(9):66884W Journal CASCT CA104006 HITS: 1 1"'" BIPHENYL, TETRACHLORO Assessment of environmental compounds by carclnogenspeclfic tests. Part 1. Formation of carcinogenic and inactive chrysene metabolites by rat liver microsomes of various monooxygenase activities. Jacob, Juergen; Schmoldt, Achlm: Grimmer, Gernot (Blochem. Inst. UmweItcarclnogene, D-2070 Ahrensburg, Fed. Rep. Ger.). Arch. Toxicol. [ARTODN] 1982. 51(3). 255-65 (Eng). Microsomal oxldn. of chrysene (I) [218-01-9] In rat liver occurs at various positions (1,2-; 3,4-; 5,6-). This was verified by gas chromatog./mass spectrometry (GC/MS) and comparison with synthetic ref. substances. After various rat pretreatments with Inducers of the monooxygenase system, the oxldn. at the 3,4-posit Ion predominated In Isolated microsomes. The formation of the ultimate carcinogen of I, 1,2-dlhydroxy-3,4-epoxy-1 , 2,3,4-tetrahydrochrysene [67252-82-8], was not detectable In untreated rats. However, It was obsd. as 1,2,3-trlhydroxy-l,2,3,4-tetrahydrochrysene [84498-37-3] -TMS-ether formed under workup and derIvatIzatIon conditions after pretreating the rats with phenobarbltal [50-06-6], PCB, 5,6-benzoflavone [6051-87-2], or various polycyclic arom. hydrocarbons. PCB and benzoflavone were the most potent Inducers for the formation of this metabolite. ABSTRACT CONTINUED COPYRIGHT 1983 BY THE AMERICAN CHEMICAL SOCIETY PCB-ARCH-EXT0378216 CA9B(9 ) :66884W (This abstract has a structure In the CA tssue.) chrysene metab liver carcinogen COPYRIGHT 1983 BY THE AMERICAN CHEMICAL SOCIETY PAGE 345 CA98(9 ) :66920E partly due to cell hypertrophy, as Indicated by detn. of cell size. The mitogenic activity of Clophen A 50 was evaluated by measurement of the mitotic Index of unaltered hepatocytes at 24, 48 h, and 7 days after application of a single dose (100 mg/kg) of Clophen A 50. The mitotic index In control animals was .apprx.0.3%, and enhanced .apprx.8-fold In males, 24 h PCB treatment. In females, only a slight, nonsignificant Increase was obsd. Thus, the sex-dependent promoting effect of Clophen A 50 Is Independent from Its mitogenic action. PCB enzyme altered Island sex nltrosamlne enzyme altered Island sex liver neoplasm nltrosamlne PCB sex COPYRIGHT 1983 BY THE AMERICAN CHEMICAL SOCIETY PROFILE 10 12217F . QUERY NUMBER 001 CA98(9):66920E Journal CASCT CA104006 HITS: PCB* Sex-dependent promoting effect of polychlorinated biphenyls on enzyme-altered Islands Induced by dlethylnltrosamlne In rat liver. Demi, Erhard: Oesterle, Doris (Inst. Toxlkol. Blochem., Ges. Strahlen- und Umweltforsch.. D-8042 Neuherberg, Fed. Rep. Ger.). Carcinogenesis (London) [CRNGDP] 1982, 3(12), 1449-52 (Eng). The promoting effect of Clophen A 50 (8068-44-8], a com. mlxt. of PCBs on preneoplastic Islands, Initiated dlethylnltrosamlne (DEN) (55-18-5], was studied In rats. The Islands were Identified hlstochem. by loss of ATPase (9000-83-3] and/or emergence of .gamma.-glutamyltranspeptIdase (GGTase) (9046-27-9). Treatment with 12 .times. 8 mg DEN/kg /day initiated a similar no. and total area of Islands. Addnl. weekly applications of Clophen A 50 (50 or 100 mg/kg/wk, for 7 wk) enhanced the no. of ATPas-defIclent Islands 3-fold In males and 9-fold In females. The total area was Increased 4-fold In males and 15-fold In females. No. and area of GGTase-pos. Islands were similarly enhanced. The emergence of a small no. of Islands after application of Clophen A 50 alone may Indicate a weak carcinogenic potency. PCB treatment caused an Increase In liver wt., which amounted to .apprx.55% In males and 20% In females compared to controls. This Increase Is ABSTRACT CONTINUED COPYRIGHT 1983 BY THE AMERICAN CHEMICAL SOCIETY PROFILE ID 12217F QUERY NUMBER 001 CA98(9):70375Y Journal CASCT CA117000 CCR 105 HITS: *CHL0R*, BIPHENYL* Residual pesticides and polychloroblphenyls In foods. Iwalda, Masahlro (Osaka Branch. Natl. Inst. Hyg. Scl., Osaka. Japan 540). Rakuno Kagaku Shokuhln no Kenkyu (RKSKD8 ] 1982, 31(6), A271-A276 (Japan). A review presented at the 1982 Japanese Dairy Science Assocn. meeting. review pesticide food polychlorinated biphenyl food review COPYRIGHT 1983 BY THE AMERICAN CHEMICAL SOCIETY PCB-ARCH-EXT0378217 PROFILE 10 12217F QUERY NUMBER 001 CA98(9):70486K Tech Rep CASCT CA117005 CCR 104 HITS: PCB * Compliance program report of findings: FY 77 pesticides and metals program(7320.79). Food and Drug Administration (Bur. Foods, Washington, DC USA). Report [D8REP4] 1981, FDA/BF-82/B7; Order No. PB82-260605, 28 pp. (Eng). From Gov. Rep. Announce. Index (U. S.) 1982, 82 (26), 5385. PCBs, pesticides, Pb. Cd, and Zn were detd. In several foods and Hg In fish. pesticide food PCB food trace element food mercury fish COPYRIGHT 1983 BY THE AMERICAN CHEMICAL SOCIETY PAGE 346 CA98(9):70749Y diphenyllodonlum Lagopus protein plasma urate salicylate Lagopus protein plasma urate willow Lagopus protein plasma urate blueberry Lagopus protein plasma urate COPYRIGHT 1983 BY THE AMERICAN CHEMICAL SOCIETY / PROFILE ID 12217F QUERY NUMBER 001 CA98(9):70749Y Journal CASCT CA118003 CCR 114 HITS: `CHLOR*. DIPHENYL* Effect of natural feed, antibiotics, tannin, diphenyllodonlum chloride and salicylic acid supplement on plasma uric acid concentration in captive willow ptarmigans (Lagopus 1. lagopus). Hans sen. Ingolf (Inst. Med. Biol., Unlv. Tromso, Tromsoe, Norway). Acta Vet. Scand. [AVSCA7J 1982, 23(3), 468-70 (Eng). Captive willow ptarmigans fed a protein-high (28%) diet, which causes nephritis and an elevated blood plasma uric acid [69-93-2) level, were given a diet contg. antibiotic prepns. or substances known to Inhibit gut microflora and N metab. and whlctT occur In their natural feeds. The'plasma uric acid decreased from 0.78 to 0.48 mM/L when blueberry plants and willow twigs were added to the diet. Addn. of neomycin [1404-04-2] (0.01%), oxytetracyclIne [79-57-2) (0.015%), tannin (0.2%, In drinking water), diphenyllodonlum chloride [1483-72-3] (0.5 mM), or salicylic acid [69-72-7] (0.25%) had no effect on blood uric acid levels. Apparently, N compds. of gut microbial origin are not the factor responsible for nephritis and uric acid diathesis of willow ptarmigan. Lagopus protein feed urate plasma antibiotic Lagopus protein plasma urate tannin Lagopus protein plasma urate ABSTRACT CONTINUED COPYRIGHT 1983 BY THE AMERICAN CHEMICAL SOCIETY PROFILE ID 122 17F QUERY NUMBER 001 CA98(9):71158S Journal CASCT CA122004 CCR 175 HITS: *CHL0R*, DIPHENYL* Cycloaddition reactions of allenyl cations with cyclopentadlene. Mayr, Herbert; Halberstadt-Kausch, Inge K. (Inst. Org. Chem., Unlv. Erlangen-Nuernberg, D-8520 Erlangen, Fed. Rep. Ger.). Chem. Ber. [CHBEAM] 1982, 115(11), 3479-515 (Ger). Propargyl halides RC.tplbond.CCR1R2X [R H, Me, Et, aryl; R1 = R2 = Me, Et; R1 = Ph. R2 * H or R1R2 => (CH2)4, X Cl or Br] underwent Zn halide-catalyzed cycloaddn. reactions with cyclopentadlene In ether/CH2C12. The products I and II were formed by stepwise [3 + 4]- and [2 + 4]-cycloaddns. of Intermediate allenyl cations, proceeding via propargyleyelopentenyl and btcycl1c vinyl cations. Quenching products of all postulated Intermediates were Isolated. The relative energies of the Intermediate carbenlum Ions were estd. on the basis of force field ealens. and of gas phase stabilities of simple carbocations. The reaction of PhC.tplbond.CCMe2Cl with cyclopentadlene gave. In addn. to II (R = Ph, R1 = R2 = Me, X = Cl), the 2:1 product III, whose structure was assigned by x-ray anal. (This abstract has a structure In the CA Issue.) cycloaddn allenyl cation cyclopentadlene energy carbenlum Ion ABSTRACT CONTINUED COPYRIGHT 1983 BY THE AMERICAN CHEMICAL SOCIETY PCB-ARCH-EXT0378218 CA90(9) :71 158S transition state cycloaddn allenyl cation mol structure pentacyclotrIdecene derlv crystal structure pentacyclotrIdecene derlv COPYRIGHT 1983 BY THE AMERICAN CHEMICAL SOCIETY PROFILE ID 12217F QUERY NUMBER 001 CA98(9) :7 139ST Journal CASCT CA122013 HITS: 1 1"'" BIPHENYL. DICHLORO Selectivity of oxidative coupling of arenes under the action of thal11um(III) trlfluoroacetate In the presence of pal1ad1um(II) acetate. Oeiko, S. A.; Ryabov. A. 0.: Yatslmlrskl1. A. K.; Berezin, I. V. (Mosk. Gos. Unlv., Moscow. USSR). Dok1. Akad. Nauk SSSR [DANKAS] 1982, 266(4), 874-8 (Chem.] (Russ). The oxidative coupling of PhR (R = Me, Et, Cl, OMe) was examd. In the title system, which leads to the highest selectivity for para-coupling discovered so far. Correlation of the logarithm of the partial rate factors for para-coupling with .sigma.+ consts. yielded .delta. * -6.2, indicating an electrophilic mechanism of substrate activation. coupling benzene derlv palladium thallium LFER oxidative coupling benzene derlv . COPYRIGHT 1983 BY THE AMERICAN CHEMICAL SOCIETY PAGE 347 PROFILE ID 12217F QUERY NUMBER 001 CA98(9) :71583B Journal CASCT CA125014 HITS: *CHL0R*, DIPHENYL*, *PHEN* Thermolysis and acylation of dlaryl tellurlum dtacylates. Sadekov, I. D.; Rlvkln, B. B.; Maksimenko, A. A. (Nil Flz.-Org. Khlm., Rostov. Gos. Unlv., Rostov, USSR). Izv. Sev.-Kavk. Nauchn. Tsentra Vyssh. Shk., Estestv. Naukl [ISTVAY] 1982, (2), 54-7 (Russ). (p-RC6H4)2TeO (R = H, Me, MeO, Me2N) In Me2CH0H reacted with 99.5% HC02H at 60.degree, and with CC13C02H at room temp, to give 61-98% (p-RC6H4)2Te(02CR1 )2 (I; same R; R1 = H, CC13, resp.). Thermolysis of I (same R, R1 = H) In refluxing p-xylene gave 95-100% (p-RC6H4)2Te, C02 and HC02H. Analogous treatment of I (same R. R1 = CC13) gave 57-68% (p-RC6H4)2TeCI2 (II: same R), C02 and :CC12, the latter Identified by the formation of 23-30% 7,7-dlchloronorcarane In the presence of cyclohexene. Substitution of I (R = H. R1 = Me; R = MeO. R1 Ph, Pr) with the corresponding R1C0C1 In refluxing abs. CHC13 gave 87-90% II (same R) and 81-7% (R1C0)20 (same R1). Attempted prepn. of mixed anhydrides by this method was unsuccessful, but I (Ri Me) reacted with Mel at lOO.degree, in a sealed ampul to give (p-RC6H4)2TeI2 (R undefined) and 88-90% MeOAc. ary 1 tellurlum dlacylate prepn thermolysis substitution tellurium diaryl dlacylate thermolysis substitution alkylation d1 ary1 tel 1urlum diacetate COPYRIGHT 1983 BY THE AMERICAN CHEMICAL SOCIETY PROFILE ID 12217F QUERY NUMBER 001 CA98(9) :71598K Journal CASCT CA125018 CCR 175 HITS: *CHL0R*. BIPHENYL* Synthesis and study of liquid-crystal properties of some optically active derivatives of biphenyl and phenylcyclohexane. Abdulin, A. 2.; Bezborodov, V. S.; Bubel, 0. N.; Rachkevlch, V. S. (Nauchno-Issled. Inst. Prlkl. Flz. Probl. 1m. Sevchenko. Minsk, USSR). Zh. Org. Khlm. (ZORKAE ] 1982, 18(10), 2170-3 (Russ). P-MeC6H4C6H4C02H-p was reduced with excess LI-EtOH In abs. Et20 and then hydrogenated over 10% Pd/C to give 60% trans-4-p-tolylcyclohexanecarboxyl1c acid, which was converted to the acid chloride and esterlfled with optically active p-H0C6H4C02CH2CHMeEt In abs. Et20 contg. pyridine to give 40% p-RC6H4C02CH2CHMeEt (I: R = trans-4-p-tolylcyclohexanecarbonyloxy). I (R = P-C5H110C6H4, p-C10H210C6H4, p-(p-MeC6H4)C6H4C02, p-(4-methy1 eye 1ohexyI)benzoy1oxy) were prepd. analogously in 47-58% yield. Phase-trans1tIon temps, were given for I. The spectral reflection of the chiral nematic phase of I appeared In the IR region. lid crystal biphenyl phenyl cyclohexane ester COPYRIGHT 1983 BY THE AMERICAN CHEMICAL SOCIETY PCB-ARCH-EXT0378219 PROFILE ID 12217F QUERY NUMBER 001 CA98(9):71823E Patent CASCT CA126005 HITS: *CHLOR*, DIPHENYL*. *ETH*, *PHEN 2-0xo-1-l([substituted sulfonyl]amino)carbonyl]azet1d<nes . Koster. William H.: Clmarustl, Christopher M. (Squibb, E. R., and Sons. Inc. ) (USA). Eur. Pat. App1. EP 61.765 (Cl. C07F9/65. A61K31/675). 06 Oct 1982. US App1. 248,929. 30 Mar 1981; 135 pp. (Eng). Bactericidal (no data) azetldlnes I [R = acyl; R1 = H; OMe; R2, R3 = H. (un)subst1tuted alkyl, cycloalkyl. (un)substltuted Ph. C02H. substituted OH. SH; R2R3 = alkylene; R4 = H. (un)subst1tuted alkyl, Ph; R5 = OH, (un)subst1tuted alkoxy. alkyl, OPh, Ph, NH2, alkylthlo, SPh) were prepd. Thus, treating (S)-3-(benzyloxycarbonyI ami no)-2-azetId 1 none with C1P(0)(OMe)2 gave I (R = C02CH2Ph. R1-R3 = H, R4 = Me, R5 = OMe) which was hydrogenolyzed and acylated to give II . (This abstract has a struiture in the CA Issue.) azetIdlnylphosphonate prepn bactericide azet1d1ny1phosph1na te COPYRIGHT 1983 BY THE AMERICAN CHEMICAL SOCIETY PAGE 348 PROFILE ID 12217F QUERY NUMBER OOl CA98(9):72079D Patent CASCT CA128002 CCR 101 HITS: *CHLOR*, DIPHENYL* 5-Pheny1-1,3-alkano-1,2,3,4,4a,flb-hexahydropyr1do{ 4,3-bJ1 ndoles. Berger, Joel G.; Tahbaz, Plrouz (Scherlng Corp.) (USA). U.S. US 4,360.673 (Cl. 546-70; C07D471/18, A61K31/40). 23 Nov 1982, App!. 136,016. 31 Mar 1980; 5 pp. (Eng). The antidepressant (no data) title compds. I (R H, alkyl; R1, R2 = H. HO, alkoxy, alkyl, m = 2. 3) and their quaternary addn. salts were prepd. Thus. Ph2NNH2 was treated with N-(2,2.2-tr1chloroethoxycarbony1Jtroplno ne followed by redn. to give 5-(2,2-dlphenylhydrazono)- 1, 3-ethanoplperidlne. which was cycllzed by HC1 to give 1, 2,3,4-tetrahydro-1,3-ethano-5-phenyIpyrIdo[4, 3-bjtndole-HCl (II). II was neutralized, reduced with Na-NH3 to give (.+-.)-! (R = R1 = H, n = 2). The (+)and (-)-Isomer were also prepd. (This abstract has a structure In the CA Issue.) pyrldolndole alkano phenyl hexahydro ethanopyrIdo Indole phenyl hexahydro ant(depressant hexahydroethanopyridolndole COPYRIGHT 1983 BY THE AMERICAN CHEMICAL SOCIETY PROFILE ID 12217F QUERY NUMBER 001 CA98(9):71987M Journal CASCT CA128007 HITS: *CHLOR*, DIPHENYL* The synthesis and the reactivity of 3,5-dlsubstituted 1,2,4-dtthlazollum salts. Shibuya. Isao (Natl. chem. Lab. Ind., Ibarakl, Japan 305). Nippon Kagaku Kalshl [NKAKB8) 1982. (9). 1518-22 (Japan). Arom. thloamlde S-oxIdes, prepd. by treating arom. thloamldes with H202, reacted with different arom. thloam Ides In strongly acidic media to give 1.2, 4-dlthlazollum salts (I; R, R1 = aryl. X = anion). The reaction of I (R = R1 = Ph. X = 004) with o-subst 1 tuted anilines, benzoyl hydrazine, and benzamldine gave benzoheterazotes (II; Z = 0, NH, S. CONH). Ill, and IV. resp. (This abstract has a structure In the CA issue.) dlthlazollum salt synthesis reaction cyclocondensatIon thlobenzamlde oxide tr tazole trlazIne COPYRIGHT 1983 BY THE AMERICAN CHEMICAL SOCIETY PROFILE ID 12217F QUERY NUMBER 001 CA98(9):72255H Journal CASCT CA129007 HITS: *CHLOR*, DIPHENYL* Synthesis of diphenyl-2,3-butadlenylphosphlne through phase-transfer catalysis. Khachatryan. R. A.; Sayadyan, S. V.; Indzhlkyan. M. G. (Inst. Org. Khlm., Yerevan, USSR). Arm. Khlm. Zh. [AYKZAN] 1982, 35(10), 690-1 (Russ). The title compd. was prepd. In 60.7% yield by addn. of Ph2PH to CH2:CHC.tp1 bond.CH In the presence of Katamln AB . addn diphenylphosphIne butenyne phosphine butadlenyl diphenyl COPYRIGHT 1983 BY THE AMERICAN CHEMICAL SOCIETY PCB-ARCH-EXT0378220 PROFILE ID 12217F QUERY NUMBER 001 CA98(10):804180 Journal CASCT CA172002 CCR 166, 168 179 HITS: *CHLOR*, DIPHENYL* Studies on electroanalytteal chemistry of rare earths. XX. Meehanlsm of the adsorptive-complex wave of the scandium!3+(-ammonium chlorlde-cupferron-dlphenylguanldln e system. Gao. Xlaoxla; Jiao, Kul (Chem. Dep. , Beijing Unlv., Beijing, Peop. Rep. China). Huaxue Xuebao [HHHPA4] 1982. 40(7), 611-20 (Ch). In the title system, the mechanism for the adsorptive-complex catalytic wave was Investigated by comparing the waves In a single sweep polarogram with those In a d.c. polarogram. Electrocapl1larlty, cyclic voltammetry, etc.. Indicated the wave Is due to an adsorptive complex. The complex compn. Is Sc3+:C1 -tcupferron:diphenyl guanidine In 1:2:1:1 ratio and the stability const, .beta. = 1.22 .times. 107. The electrode process consists of the following steps: complex formation of Sc3+ with cupferron and diphenyl guanidine, adsorption of the complex by the electrode, dlssocn. of the complex, and redn. of cupferron on the electrode. scandium cupferron diphenyl guanidine complex polarog phenyl guanidine scandium cupferron complex polarog electroredn cupferron scandium complex polarog adsorption scandium complex mercury electrode COPYRIGHT 1983 BY THE AMERICAN CHEMICAL SOCIETY PROFILE 10 12217F QUERY NUMBER 001 CA98(10):81396G Tech Rep CASCT CA174001 HITS: *CHL0R*, DIPHENYL* Radlolytlc Investigations of solutions of organophosphorus compounds In cyclohexane and benzene. Otrebskl, W. (Vienna Unlv.. Vienna. Austria). Report ID2REPU] 1981, INIS-mf-7209, 190pp. (Ger). Avail. INIS. From INIS Atomlndex 1982. 13(20), Abstr. No. 702129. Several organophosphorus compds. were used as model substrates In cyclohexane or benzene soln. The systems were Investigated by pulse radiolysis technique and steady-state irradn. methods. Dlphenylphosphlnous chloride, dlphenylmethyIphosphlne. and trIphenylphosphine were chosen as representative solutes. Spectroscopic and kinetic data for characterization of the various transients were obtained. The final radlolytlc products were analyzed following steady-state and multipulse radiolysis. Reaction mechanism of dlphenylphosphlnous chloride/cyclohexane system was elucidated. DIpheny1phosphorus radical was Identified as a primary species. The reactions of dlphenylmethylphosphlne Involved the same radical, but to a lesser extent. The reactions of the primary radiolysis products with trIpheny1phosph1ne yielded mainly adducts. org phosphorus compd radiolysis ABSTRACT CONTINUED COPYRIGHT 1983 BY THE AMERICAN CHEMICAL SOCIETY PAGE 351 CA98(10):81396G dlphenylphosphlnous chloride cyclohexane radiolysis dlphenylmethylphosphlne cyclohexane radiolysis triphenyl phosphine cyclohexane radlolysls COPYRIGHT 1983 BY THE AMERICAN CHEMICAL SOCIETY QUERY NUMBER NO OF DOCUMENTS PRINTED NO. OF LINES PRINTED 001 28 811 PCB-ARCH-EXT0378223 END OF REPORT FOR PROFILE 12217F PAGE 352 PCB-ARCH-EXT0378224