Document KJxGLaeayD0G4EMpnkzL80Xzw

One of the things I .promised to do at the last meeting of the Central Committee on Medicine and Health which has slipped my mind until the present was to write you concerning the potential studies that the Public Health Service would like to see done on lead workers in industry. You Will remember that as API's representa tive on the Lead Liaison Committee with the Public Health Service I was provided with certain studies which they felt might be worthwhile undertaking in an attempt to answer the question of whether or not lead is having an effect on the health of the general population. They passed out to us the five sheets which I have attached to this letter. Of particular interest were the studies suggested by No. 1 under Occupational Group Studies on Lead. In this regard I agreed to contact the medical directors of the three major automotive manufacturers and see if-they would be will ing to do studies of this nature on their lead workers. In addition, I agreed.to contact, through the Central Committee on Medicine and Health, the medical directors of the oil industry to see if they might be willing to undertake comparable studies in leadi workers in the oil industry. Actually, the.number one study under Occupa tional Group Studies on Lead parallels quite closely the epidemiology lead studies number one project. : i The question which I posed to the Central Committee on Medicine and Health at its meeting was whether the medical directors of the petroleum companies would be willing to participate in such a study. In my view, the data .are usually probably already available in the medical recor4s maintained by the various petroleum com panies, and it would be simply a matter of getting the data out and putting it down on paper. Thus, blood and/or urinary lead levels could be correlated with any critical findings that might be available, including hemoglobins, red counts, or other blood effects specifically. It is very likely that nobody has done red cell fragility studies, and that this information thetefore probably would not be avail able, but it could be that one or another of the petroleum companies would be willing to undertake red cell fragility studies in their lead workers and attempt to corre late this with blood and/or urinary lead levels and environmental lead levels, if such are available. It just seemed to me that a study of this nature could be done by the various petroleum companies involved in the Central Committee on Medicine and Health and perhaps collect valuable information which would add to the already available information indicating that lead exposures less than a certain figure do not.consti tute a hazard to anyone. I would sincerely hope that the petroleum companies through their medical directors would cooperate In such a collection of data for the Public Health Service, since it would be invaluable to the Environmental Health Committee in its discussions with the federal authorities on the hazards of leadin our environment. As indicated, I have already met with Bud Irvin, Marion Jocz, and Dan Steiner to see if they would be willing to participate in a study of their workers. My letter of December 7, 1966, outlines more or less the thinking I have on what this study might consist of, and I.am including it since I think it might be of value to you in attempting to assess whether the petroleum industries will coojperate in this, study. . After you have had art. opportunity to review the attached information' and should you still have any further questions concerning the nature Of the study to be undertaken, perhaps we could get together sometime in New York and discuss this more fully. I would hope that a decision on this might be reached at the May meeting of the Central Committee on Medicine and Health in order.that this7 information might be conveyed to the Public Health Service. Might I also add J parenthetically that lack of cooperation by the petroleum companies in such studies might well be seriously misinterpreted by the Public Health Service. ' ii - Sincerely yours. REE;bsn Attachments - . 1: l i : ? ?: i i KE 0018469 if T %* ft eajssr mmsmts of fce^Xsfss f&s fc$&9.t!i efforts of .o&oolb cap^ t^ ' issdVo^essrsr to to* cs^iisSlffia .: tadcfttry aracos^s# Xsgsssi'OSi 09 SForStiag J^vsls of lead oso i^?tiaijr':fH' K0Sii*c?ed a&d blood cad vtsris. ero tabsa at periodic. istosvalgi it BSy24 ls> pceaiklci to do tao<& retrospective sad t&&&&ssfr' to' &&&.& cotefc- of t?eria.f^s5aa to load, fa'tS. ra&iflg eavirscKoat* #3 jsu3$lB@3it$l l& ;$? o2*9r&53# vtmjlZlr* in gives bleed-Xead after a c&vsa period of cess^niXe^X erpeces^ Sli&s XwiOttiSy* o^ea&sl te* Xss tima t3a.t seQtttrsd 7 css^ay policy to f g ^u &t b to a lesser eisscsur# 'Taua, r^ecce:;: '-vitb bleed ioad 2o 0Z3 cf #00 or #07 oilligraaa s q g f 25i c,r;--? of Llc',1 ripX-i neactituio cao osth&rt trith otter l&codl y~'`,z'lrj rel-liv: r> ttv ccbrr&s# S3&ra ccu&S bo relieved ibrccsbooa tcoir catiro vnx^ias Xivos ttisa special prsarlsloa t-t.lr fee catsrtaiaJla^ tbelr bidlty r.nd csrisld&y erpe^'ere::::? r.o *-;.:21 raj tl-vir roeer/rs 5?. fob nCsifta* fsrs.o o^plegtref o? c.vjrco* evo rest cuftailo cs fcb$ pleco of etti$7 tenant:* cc V.;"? t'evCJ r^llico reiffielcatl? 2sst?a nesto-g of ecr&so cc t'.:it vr^Zr-z^:! ceasariresa r.pbt to rrsCo of Ito px-7 c&aiic ';* lb c!2. e- :53i3l ears ve^ald hreeo to l eit-.i to fr.-uvs iX.vj r-evo dstaiXtl r-:^,1>sis trus ctio of tie r,:tl tsloc/J colls aai o**'.-r cc-ar,tit~*;atg of tbo I^catolceia e^stes* 3 fifties# psztic?2r? ctr* v-'Z I:i"-o to . Iro cX'yoa to a tfcsrc^i csaiait4oa of t.'.;^ o`-^r L'efv rr^lvres cfffectod load oEsscsaro* err^rir-itlf tire o it.ie erTro 53o-t5 TOJtiao' iafuotriaX' psife:?-, *, ^-.\te:-X7 Btd? %r^ul &M cjac2* to c-ar cf too ie.'-.X'fi .. Xe^3* 2, ?3*o recsuapvef of t^9 toaats^a crchcrdistsi vho v o t o es^resd to Itad szoLssfia s^wasa1 to offer a s h &&Xo voiilolo.- - foy eeIfesiolejio rsocarcii iato o-eeuastfcaal espesuto ^Itl^ s-sao r.-z**ozz\r^z,ic.rncaiv&s of t'esxa eei c^aiidroo# TJs? rarigo of blooil lead Io -t ^Xs Sovzd vjrAsX frost t&oro ^reseot:- to 0*3^ tOi JlSSt XoStej? tfa 4|p3 |5jU3^?^S3 pO? ." X0 blood# tbs tiarciiijolil cotsblJUoosl 1>7 c?* r^oo* cao rdsot t-v^a foiled ceinrto of trivia bleed 2-ea-d eo of tba etato of tXo c^i^iaal oteelj, f*BrtSor difforos&tiaticsi oi^at elso to tsss cS to esa sad cos dissira.Ssi'Xioa of tla pc^iaticA ^eas^sa- .tsM'' e-tts^|vit'mi'^ fej:.:;^2ssib2o ip,!'^aro >' tact?, to obfeln statlatlcedl^ oi.^aificart diffcroac03 ta so- Xe^si; grot3p' e s N^* it voalsi to asfloesary to loea lato tiro alicsaticssi of 'ilea aa rcxtaOir j too corei^at of tta tasJ?. zt ta <i*Aito coaseleael^ ttst evoa o ^iasaRj** etxfy ni.3-t 12 -ba for foUcw- &:d eisift load to of cotiroo# <5370^ C12 tZ& ^esp-loblio z-oaults# of tbs M&o, : . KP 0018470 l N20193.01 - KE 0018471 latorategy - of aaigafo . 1, Os& of tbb m$(Qp of cmfh&ti&B tedattfr Gt&fi&sa? is flsst -iSSioiS&oca of toalssMtifto to eoo'coastaat M V" .odj&tartiSileif'S&sd ia ttio alF2/iui .o$d. Tfagt^feiv "'- , tswfijrasoa over a volAtiTOl? leas c?lsd of && Ao k *. eoodiasl^ it in vzsy slao&o to a$s>a gsws& of somsal, ? rats* f? ossg'&lo* wSsreso <fcs&Gs$<l dayissj f^&T'eat&o ii^pi'l3^v mi; ;$$&& '-' noSptCST* 5 toll 3 CBGt&K? ?0S CE$8S5ai to & 2CV>1 . ;- etc* *Zrj) effect* of load eaa Lo Cstosaised usqwaiiaiSy. -:; ea h1<s?d ?w?s^ria-'sd wSnvrjr o^^osfibyaria* Etoto? ^.-`;- l^t&alcsrioal G&oSloa aad caAsr^pS^sSclcsical G&tidioa caa ?: . to rodo Cbsiag tl;o cesrso of tia t^I;* .soas rjxzro?! caa ' also l:o lo&ssl at ia tMa aaiasl esp^is^tatioa fs?cs. tt bioslxalcal ead gSysiole^ioal* jfoiai of vi^-es sa , .jfpllpllil' = ; .''I!pl||fp^:lli|iifet3 if tsStf* esa & esauusned sees easily ea tia &sr oc^aa mm m& sr^a^l gyst^db* *. 3# =o <&2? stst^y vs34 vesy t? ftoiasla c s k k S to'&tt&agft to fsasnaia tSo caicso aod estsat of e?x3ica sSiffwontiatisaWSSia t3>o of ctafy trralil iaatlcally j^iTallel t2 sseTiota HE 0018472 :j^fpcafflratat:-ca load r:':- ' ^ ' 1, 'igvdZuatb ia&zo ca*efiauUy tfcaa tsss teea dsm^s -'to: eeat'Ots of Zmd otism? t&&$. Sbis.--. w&k& bo teio oSailed la t vdcSaitias* - q 2 poieati&l scaeroea o,fj* Sssil osts&ctica sad e^olsgsaasat . plssyfesj s&!%!3h ctcsj? &&* ot& &saa?aSt sad E^ssdaJ^- - _ psf'jeso dur^aj rooissafcisa iss'siUig of satssaolsllss osf- usfc fres csltica of old and &s& frees oa-sito ftoralss of %&* Sot&satio-i of tSa ftrospasaej of &se$k sserees ia tsso &ad spae* - ................,. ., ., . '. ". ' ........... .- V'.i Vi-?. 2# Sfed? ef *cs& fa crjf'ca Sssd pcja usd tls e13t da ^MoSl'' tfcc? g^sra*- X&a&Us&ap attoattca e&nald fco sitsa to crops towdJis varjias osgesase to &1-* lead rc aufssssMles* . post ecatroi opos?atdtsxi asd ia&sstsgr*-' '-*' * 3* ?h Food and E3?ogf f^aiaiciratloa !*t!i as fsairo'ceat&sssasras feed noaitoirtj prcs?323* ^sf^ar^ssoatsi s&ou3d'$ .- tiiM&fc .46^9 fosm of 1@3 ** e&areolXlasco is t^soo psegsstss* ....... ^ ' -; . ^ iv~> .... ' --,. .vr'?-? -. ?,?=,, ;. 7 r -' ". ; ' . ". ' - ;- : : 7.- ;./. - -: - - - .- .- -- --;'vv?' -:.-...- -. ,:'-.:. ,, .^,. .... .... ,-.>/ ;; ; . "' / -;-5' \ ' '/_---' -v; ? . ?.'- -;. ;- :...s.r-" -- - r *--v ^.-- ' y:r 7/ .-.-. :- . - ; :. , 1\ :r ;;"v a; ,- ' "' ^^ ^ ' 7; -v'^;.: 7^7.'- -<v.,..,... 7,, -.f v-v- v.t :.-,,S.-7.7'.---.V.-...n' - ,. i-^ -b*,, . .. -. . - -!*.:` \;;?.. ' r;7i.- "'..": ' '7 ' -'..; :' ' ; '..:."..:..V..."........y^-r-y...s.'.:=....^.V....i-...-.s..-..7..:,:- :vi...... .-, ..-.-..---rv.,..' KE . .0018473 V" A 7 Occupational -Group ^esr' &** ' 1. Several fragments of current information, rninly related *_ to the blocd .-2omiag system, indicate* that blood and urino lead levels presently believed safe, may sot is fast be so* Hose of the information, pointing to this ' ` "- possibility is, satisfactory for' uso in altering"control "`v. progress. It does raise enough doubts so that careful reevalimtion of current concepts is ia order* This can. . \ probably fcs done - by the use of existing industrial data iron the supervision of load-exposed employees to a bv Iqrgs extent* if employee {?ho, have be'en eafuained period ically have had urine loisdi ^pyolU hljexki load'd JL^ydlW . ,, i -. h^jipglobiii ldv^t, rod 'blood cbll count, ilrbd-',t3lij^6dtlcbll v\ - fragility, and {urinary coproporphyria done a preliminary -..; btirvoy cquM ''easily' 'bo dons1' #7 ^oupMg" as cord- ' - nM : -A* h`'.-.-'. iHP ;'t|tf ilf' 1 . level it should bo apparent in such a design... Evidence for or against, other types of injury from lead could - h 1 also bo sought ia the sene pattern* . -. t . - _ . }. 2* There are also unsatisfactory fragnent3 of infemotion indicating that load exposures above and/or* boles? those producing lead poisoning may also produce chronic illness, v ""' particularly Isldnsy disaask* tlMir problem.also -marits core careful study to 'decide vrhethor cr not ueh dosage is in fact occurring, Tco industrial groups lend thesB0lv3 to such a purpose. Groups mentioned in the first section can bo classified into cohorts by length of espesuro or by blood levels (cr by both), and followed for differences in life"expoctsacy and health status v. . as cospared to noa-erpessd groups* Cases of industrial lead poisoning could be subject*to folle-up study ia j the naaaer used previously for children by Henderson -- and by Copper? (sic)-. Comparison * groups should probably fee employed* .. . .. ; -.-. -. ... ,, V-vi-.'v- l- - k 0019174