Document KJoO1OZ5J8G5041L4RDg4Ejw6

OLOriT (VoL 1*4) j UM rnn tn evo wleetHrcly tnhibus fnr 10-10 min a mtcleopUsmlc ln> of **HA polyrpvfa** m rat livrr but thr synthesis in *ro of all ip-cie# of 'Ifaf KNA rriuaiai blocked for *ftr>t bwra.W. F. L 3 BROOKS. ROREI1T n. Jr. and JAMES A, VICK. (Dtp. flnn CV .oiler Vvd Army |nrt, Re*., Walter Reel Army Med, Cnlw Washington. P. C. 20012. 1/5A.I Tniftir-tral of bee vrnom to mice, Ay* M AMpiL J iT2(7|: 2&7-2aj71ifi2.--Venom < Api* twriiihra iwycN. either t.v. or o.c.. into Mpcnnntal M'itiili. I.V. wifciioi* ranged a prrclp*tnun deertaoe In blood prva* bore vidua 2) *ee la both dxi and monkey*. It aloo decreased heart raft and depressed respiration. D-**ar* of 5 mg/fcg lb dree* or 2.S mg-lg hi monkeys, t.v., caused death from cardiovascular failure. Similar respmsrs were noted alter o.c. infections, but median lethal dotares were burlier: 200 me'`he m i^t and SO mg/kg in monkeya. Tie former is equivalent to about 2000 bee stings. Smaller itoupl were fatal to mire. OhCf f*ysiolopcal reactions are noted, --J. D. HitehcodL 34772. ULANOVA, 1, P,, A. I. KHALEPOnnd A. I. EITTNGON. (Inst, lad. Hjrg. Oervp. Di#,, Arad. Mrd. Scl. USSR. Moscow, USSR.! Insledo* Tiitf kumuljativnykh avnmtv khtmirheskikh wwdmewit la porocovom orovae kak oenma prncnuiiwar.iya khroniehcakixh tnUAnifcatxU. (Study info cumutiltvc_prifvrtiv of chenueit comnound* at the thresh* old level in nsstv fnr pt^m* of \ (JG TR THOF 2ADOL I toil Jv-39. 19(f. |Lnc(. vmm,)--Cwnvlttii poprttri of chemical cunioundi at the threshold of their acute action oere analysed. Cumulation coefficients were deduced from Ih* integral eat changes and with reference to the summaryrthresheld -vies fea turing the funclion.il state of the nervous system. These coefficient* proved to be mum inferior to coeffictmts of cumulation dc***.^ined with reference to the animal MnnUty Imres. The cumulation coef ficients st the threshold level supymrtcd a well-marked cumula'i** ci- ptetty Of Cense no. carbon tetrachloride, Tn-aminobcnaotrUio' ride and uorpiohnc. This was supported o> tr.c data derived from < trorJc ex periment*. considering CCI4 and benzene, also by the ava.tab^e cliniol and hygienic observation*. The estimated coefficient of correction between the area* of chronic ct:co and coefficients nf cumslr'lon for ttw substances under study at the threshold level vat 0.k9. v>ii makes It possible to forecast possible development* o! chronic poisooing. The lovestiptiai time was cut down to a maximum of 1 mo.*-*. * *, K, * *rn. Kont`,_rvA.>f.s..L, e, CE5v?.^:i. r, R. VAK/IDV5KII and O. P, AHKKIPWA. (Cent. Res. Inr*. Tubcre,, IfifL lealih USSR, Moscow. L'KJFU Isvchenir prcnitxacmrs'i gisto- geman^hetkikh toar*erov pri nisticrmykh rcr-himaxh gtpertoncheskoi qfcsigcnatsti r eksp-rtaente, f Pc-r.^nbifify of mrto-hi-maue tern-rs to different rertmey of c-rcri-r-nuii hvi^fiMric inn.j LKaP fettlUAt>F-STfcj.iUL I'.uj; UUn. M72. 1 fcngl. *jmni,|~Ex- peruovnully, 70 guinea pigs were subjected to MKPjt Oj in therapeutic (1*2.2 up to 3 at*; and toxic (4-Satt) rr.iir.fi of hvjvrMne oxygena tion (or 1-4 hr. Klstolc^y and radioactive indication Ivtift strcpiomy- in-s3* id 20.000 U/kg and wu* 14.2 yCi activity tn 1 ml) were used to assess various permeability levels in the furto-fcemaUc barriers of the hsft(*. liver, kidneys, spleen, myocardium and brain. Tone rerun** were aceomptmed by a universal increase of vascular walls permeabil ity. conditioned by structural lemons of the hiSto-hemaiie barriers. With therapeutic rejames, vascular pcrmeabiliry rose only in the splvea. Rvcr and kidneys. i.e^> U the organs with an increasing functional ac tivity voder hyperbaric oxygenation, and was not accompanied by histo- itneiwal changes of the main elements of the hlstoHiemaiie barrier. --J, L. 8. >4TH. CONDER. D, p, C. OLOFFS and T. S. SZETO, (PcstoL Cent4 Dep. fiiol. Scl.. Simcm Fraser Univ^ Burnabv 2. 0, C*. CanJ CLC sefwrjtt'vi cf h-rbiehlor ctnside oivchlord-me, o- and v^rhlordan*. BULL tSVIHOJ Cu>.1AM YiCrjoZ Uii~ JJ-Ji. lT717~i,i. liquid ehromstograitfijrj c&lumna were uved to identUy and qtumtllate orpahochlortde pesticide retdwi. Such as 3V OV 1. 2T SC 30 pius fe OF I, or 2" Cv t plus 1`T CA* 210. They did not satisfactorily sep arate the domppund* of o-ehlonline, y-cMordane o,t>ehloriliite and hepeachtorepuidt. Cjs chrumaicyrapn Micro Tck MT 220 wiLh NJ-03 oAectrno cepture detector method was employed to thin rxpcrlmrht. --J/P.K. 3477S. WALTSCHEIA'A. W. (Forvchun^nlnat. Arheltsvrhuta. Reruf- akrH UKd. KrUo N.rwtov 34. Dulc.i. M. SLATFWA and I. MtCNAlUAV, Mudenvcraewteruneen wcmen Kiltcn durch Chrrei- lache Verabrelchwi* m Nirkeltulfti fhaw.*ev term iCmir.iinlifti r*< nirl#| in rn^l 1.XF to long (JihAT' Kl/4); llt-lT5, liiutn^irfliiKl. summ.l--FoUowinf lonq-term t-suUiu idwlnlwii m rata, oeverv lesions In the ccrm calls V aLrly In sfwrmlocenvata could be demonairsted. Very lew rhaiif* 4` M* ohaerved in toy livers s*d ktdnevs. Nickel sulfate bad a da* ht^ oaloua effect on UsUcular purenchym*.--A. 6, M, 14T1. IiAMIAFTV. A. V*. A, N, VAZIN and A. C, KOCIICTLW. (1 t(. Kin* (M. Hrd, ln"tM Gorki. C 'dR.) K ftlmrotn itvetedl, uosmkxyuihchikh srl dUUl'nom voadaistvii vtmtohlorlda. I l,ath^eneaia I 23)7 (Mf. I*. I*73| Tt d chnnrea devy1npln; due tn lonrHerm -ifp,-ure tn the effort nf *tjib cMonde.I U(. mi 1`iuif /ajiol i'ETTT TCJT. " summ,i--IUtdlta and rats which inhaled mylrhirt*e (wm-- n a tmat ptmlitiblf cnoenuralinn fP.PJ-o.tH m-/fimU(vtp>rwei*i a A-mn log atl-rm*nd eaaminalmn by fdiynmiogieal. hirti*inral. ht<*mnr- y phoioetcat and rocutgetuutenaitnm-trtc seilwA'. I!sr-i tn me alectnc activity of Um* hypnchaiafmr. Iitfefulmnliwuu and il (roubles of the cardumascutar ay.jem were disclo^d fVvr|,#jnierJ of rctorpuve manifestattons tn the bone titaut was bnurv out mnr- ptolccicallf tidsdt(t{ntmti-ronic^vilncicil(7. An nf-reere m drawn as to a key Importance of hypothalamic dysfuncimn n the |nm<i- gcoests of the disease, this dysfunction Civing nse to neurdtn*<iral and neurovascular troubles leading to th development of dystrophic p-o- tttKi In the boos tissue.--P. L b. urn. RAZIN, SUZANNE and ALBERT DELACNAY. ICVTO. In'll. Pasteur, Serv. Pathol, Exp., 92-Garrhea. Tr.f Action eaercee (nr n ubsUncts lathyrogenea sur le collarene de granuJnm-s. lAe*i<i ierted bv hthyrrctnif luMliinc#* nn tnc enlLi-^n nf eranil*n. t*s y HEDD SEANCKS ALAU iQ SLU t> iCI I.AT (i'AlCi) ItnMi 1972.--Polyvinyl S|hXicei were Impbmtcd x.c, in Witiar rats. Ten d.ty hater, penicillamine was given orally in a dose of 20 me, * ICO q of *ncV. In another group. p-mercaidocthylamiM was given m a done of 0.3 mg/100 g, |,p. Granulomatous tissue surrounding the ipmrr* and nor ma! skin were extracted to give neutral and acid soluble collagen, col lagen labile ml 60*and insoluble collar**. Doth dru.TS r*ve eomturar.ic results. They did not modify the total collagen of narfMl skin, tu: de creased the collagen of granulomatois tissue slightly. Neirfrat soluble collages was Increased and insoluble collagen decreased in both type* of tissue. The labile collagen Increased in the granuloma and dimin ished la the skin. The acid soluble collagen mereaned 200> in the granuloma and 107 In the Skin. Intermolecular bonds In collacvn which are sensitive to lathyrogens are comparable in granuloma and in nor mal skin.--M. 12. S, 34771. KUDZtNA. C. D. and D, l. COLOVAN*. (A. N. Marreeva Kiev Res. Inst. Gen. Publie Hyg., Kiev, USSR.) Sravnitel'iuya ottenka zerbltsld9v gruppy khlorbcncoinoi kialoey cMutamo-toksikoltv-icr.c^Him metodom I metodom kul'lur kletcAc, (romyirative *anitary-tnvicnl.i^Iral and cell-culture rvaluattm nf the crnrr^nrmf acid hrrht.-> i? group.! * VKACI1 DEl76 1. 123-I28. mu*. 137^.1 ngl. sumc.ilxna el chronic sanlUry-loxlcotoglcal experiment on rabbits and a study nf the elite: of cklsrbcsxtie herbicide grot*!* td*ai* but Utv r*vM* oy these 2 method* cnowming ths tovi:,ty o! Ui- herHcide* e-'inci^-d. The woe of cell-culture method for rapid hygienic evaluation of the tox icity of Some herbicides Is promising and further Investigations cC this method arc justlfied.--P. L. W, 34779. COOPER, PHILIP and 5TEPHE7* H. TOUNS. (Drp. Surg^ Bronx Veterans Admih. liosp., Lfonh, N. T. 1WC3, USA.) F..-1 tK-irr.jp between smoking history and complications immediately folio**cr- gerv for duMcr.il ulcer. ATT SINAI J MdD 29Ur 2i7-^zA, -- No svidenec is given ui an association fcttnm smekmg and corapura- tions, nor between amercing and oirat|vc mordliiy. nor bvew^cn jmdt* leg and day* to discharge. The most obvious trend it probably predict able, namely. foUcnta over 90 have more complications and a hazier mortality rats than those under SO. tn spite of the relat'vcly large number of foticnt* included In this re^rt the smiling habits, the sgc distribution, and disease rate m the population studied are quite lurly to Older from (he genera! population. Some inconsistencies were found between smcdiing histones taken on the same patient si didrrrnt times. This may have resulted lrom the quality and accuracy of the informs- Um 0veo to the examiner by the patient. Few, if any, generalities should be drawn from this research. Results appiv only to immediate poatopcratlve findings and do not apply to long-range effects of smoUng upon the patient after surgery for duodenal ulcer disease.--. M. D. 34790. U9TSA, F. M. and L. A. MCTTRC/A. (Fac. Postgrad. Med.. Kgo Med. Inst., Riga* USSR.) O klintchexkikh om^bennostvalUi auorol'ykh polincvrltov. IClmtcnl traits nf alcoholic rnlvnvuntis.l ZH NEVROPATOL PSIKH1ATHIM il b KUUSAKOi'A IJlif (A'i-Lil. nil. (Engl, summ.)--The traits of alcnhnltc polvoeurUis in 27 ftifirn'* wern Studied, Four nism clinical variants of the disease were distinguished. The most characteristic and frequent form of alcoholic polvneiiriii* was the syndrome of aluggisti piralvsts m the jxirt* of the lucr vfiremittes. A more commcn and mued form of ifyneuntio. sensorial and tactic forma, were rarely observed.--J. P. K. 34791. 9TCGER. ROBERT E. (Coop. Eft. Setw., N 31. Sole IMrv, Lae Cruces, N. M.. t?A.) Native p`iits 10 hum in*. J RANGE MANAGE itol)1 ^i-7i. Itii27--A summary is given*ot the toxic peinciplce, the punts, toaic pxru, symptoms and some general comments for several commonly toxic plants la the U3A.-D. T. S, 34712. PA 103, RENE-RAYMOND and ANNE-MARlC TESTER. (Fac. Rartirt Lab. Matlcre Mrd., 4-aw. 0>*ncrv*toire. tS-Pans 4. Fr.J Presence de substances Su grouye dee Cucurhilatinet chet diverves Euphorbiarees loxlqu** sfricainec, nuamment chem tuproww* mm* briuZfl Fax et K. IMm. (Freannce n| nf ih- nf ru* 33 curtiHacfnes in viruHie African umic^.u^wiiUqcvav MjvtuH/ to >U S* (/> a cn o CO 00