Document KJODqN40KLe26BOvr7azN6a1K

3M Specialty Materials ~~~ 3M Center P . Paul, MN~55144-1000 . St 3 75 7 - Ir _ - -., ~ May 17, 2007 Document Control Offic 6 eDocktAR-2 EPA East Building, Room 6428 1201 Constitution Avenue, N .W . Washington, DC 20460 f .. Phone : 202-564-893 0 Attention: OPPT Docket No. AR-226 (Mary Dominiak - Room 4410 ) Re : Information on Perfluorooctane Sulfonate, Perfluorooctanoic Acid, and Related Compound s Dear Ms . Dominiak: One of the documents in our May 10, 2007 submission contained some copying errors . Please substitute the enclosed good copy of the Final Report and Appendix, "The Effect of 3 Perfluorinated Alkyl Sulphonated on Cholesterol/Bile Acid Metabolism in 15%-Fat Fed E3Leiden Trangenic Mice In Vivo and on Fatty Acid Conversion into Cholesterol in Rat Hepatocytes In Vitro" for the copy previously submitted . The study is not confidential. Thank you very much for your assistance . Very truly yours, Michael A. Santoro Director of Environmental Health Safety and Regulatory Affairs 3M Center, Building 236-1B-10 St. Paul, MN 55144 651-733-6374 (phone) 651-733-1958 (fax ) E-mail : masantoro(a)mmm .com cc: Dr . Jennifer Seed Mr . John Linc Stine, MD H Mr. James Kelly, MDH Dr. Helen Goeden, MDH ~~N. .~~ c ~7 NO ~~' (with enclosure) ~0 ~7~`~ / . . - -' '---- , ., ~~ ;;; .'1 p .2 ti t' FO-repor THE EFFECT OF 3 PERFLUORINATED ALKYL SULPHONATED ON CHOLESTERoL/BILE ACID METABOLISM IN 15 % -FAT FED E3-LEIDEN TRANSGENIC MICE IN VIVO AND ON FATTY ACID CONVERSION INTO CHOLESTEROL IN RAT HEPATOCYTES IN VITRO. Project I study number 031 .1007413M-02 TNO Quality of Life TNO Biosciences Gaubitis laboratory Zerr,ikedreCr 9. P .O. 8ox 2215 2301 CE Leiden The N ethe-A ends Phor.e+31 71 5181209 Fax -3171 518 1901 Authors : L.H. Cot-.en E.J . Pietaman E . Hoegee-de Nobel In assfgnmetri o f 3M, Iti4edfica! Department study monitor John L, Butenhoft, Ph.D . . CIH, DABT Corporate 3denUs t M edtoat Departmen t 3M Center, 60 ding 0220-02-E-0 2 SLPaul, Min nesota 55144-1000 USA Phone: +1 .651 .733.1982 Fax: +1 .651 .733 .1773 E-mail : i!bt,tenhotfPmmm .ccm Study director. Dr. Louis H . Cohen Status and Date: Fin al version : 04 December 2006 xd Previous versons: Draft 1 : 18 October 2006 Dra't2 : 30 October 20C6 Draft3 : 28 November 200 6 Nurri ber of pages : 3 5 Authorization by Dr. P.H .A . Quax, Technology manager of Va pcu(arand Metabolic Diseases : ~'. ~~ ' " ~,.' ~' " . + 7; i r . , Signature and date : ~~~ ~ ; j j L( U I of 35 CONTAINS NO Ca l ;~. o~ 3M Specialty Materials 3M Center p' 3 St . Paul, MN 55144-100 0 651 733 1110 r ~~ JL J; ~ May 8, 2007 Document Control Office Docket AR-226 EPA East Building, Room 6428 1201 Constitution Ave ., N.W . Washington, DC 20460 - Phone : 202-564-893 0 ".. Attention: OPPT Docket No. AR-226 (Mary Dominiak - Room 4410 ) Re : Information on Perfluorooctane Sulforiate, Perfluorooctanoic Acid, and Related Compound s Dear Ms . Dominiak: This continues 3M's voluntary submissions of data on perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), and related compounds . We are enclosing paper copies of the following : Final Report and Appendix, "The Effect of 3 Perfluorinated Alkyl Sulphonates on Cholesterol/Bile Acid Metabolism in 15%-Fat Fed E3-Leiden Transgenic Mice In Vivo and on Fatty Acid Conversion into Cholesterol in Rat Hepatocytes In Vitro ." TNO Quality of Life, TNO Biosciences . December 4, 2006 . Apelberg, Benjamin Joseph, "Fetal Exposure to Perfluorinated Compounds : Distribution and Determinants of Exposure and Relationships with Weight and Size at Birth," dissertation submitted to Johns Hopkins University (Lynn Goldman, thesis adviser), August 2006 (publicly available at Proquest .com dissertation service) . Two DuPont documents produced to 3M by plaintiffs in litigation referencing retiree half-life data which corroborate 3M's retiree half-life study : o Playtis, A.J. "Washington Works C-8 Industrial Hygiene," 6/30/99 [half-life data is on the page stamped EID510286] ; and o Playtis, A .J . E-mail to G .W . Jepson, et al ., Re : Pensioner Blood Data, 8/8/00 . We also note that in a letter to the docket and agency officials dated February 2, 2007, Robert A . Bilott, counsel for Plaintiffs in civil litigation in Washington County, Minnesota (Palmer, et al. v. 3M , provided information regarding levels of perfluorochemicals in the bloo d ~~t`ITA At ~~ /+ I,n ~~~~ ~ Q ''JoZ~ p. 4 serum of fifteen individuals in Minnesota . However, it appears ten of the samples submitted with the letter had already been submitted with pri or letters : SAMPLE NO . SUBMISSION TO THE DOCKET L7652-25 May 12, 2005 letter from Mr. Bilott L7652-27 May 12, 2005 letter from Mr. Bilott L7932-1 October 20, 2005 letter from Mr. Bilott L7932-2 October 20, 2005 letter from Mr . Bilott L7932-28 October 20, 2005 letter from Mr . Bilott L7932-39 October 20, 2005 letter from Mr. Bilott L7932-51 October 20, 2005 letter from Mr. Bilott L7932-52 October 20, 2005 letter from Mr. Bilott L7932-53 October 20, 2005 letter from Mr. Bilott L7932-54 October 20, 2005 letter from Mr. Bilott Please feel free to contact me with any questions . Very truly yours, Enclosure s cc : Dr. Jennifer See d Mr. John Linc Stine, MDH Mr. James Kelly, MDH Dr. Helen Goeden, MDH Michael A. Santoro Director of Environmental Health Safety and Regulatory Affairs 3M Center, Building 236-1B-10 St. Paul, MN 55144 651-733-6374 (phone) 651-733-1958 (fax ) E-mail : masantoro@mmm .com ~