Document KGeEXLyKb3xgv9Oeqmev4BV40

Ouly, Finland August 7" 2023 Polyvinylidene fluoride (PVDF) hernia meshes like Dynamesh IPST is used for repair as well as prevent parastomal hernias (PSH). This specially shaped mesh can prevent a significant number of PSHs compared to controls without the mesh, (1-4), leading to better quality of life, less stoma related morbidity and consequential savings in health care costs. Previously widely studied flat mesh (keyhole technique) does not in PSH prevention (5-7). Yet, the European Hernia Society recommends to use a prophylactic mesh when a permanent colostomy is constructed. Dynamesh IPST is unique in design and so far there arent comparable products. The architecture of the mesh has led to significant improvement in parastomal hernia prevention. The randomized controlled trial (Chimney Trial) recruited 143 patients in Finland and Sweden (9). The 12-month results of the study will be published shortly and will show the benefits of the mesh without mesh related complications. The withdrawal of PVDF as a material of hernia meshes and denial to use Dynamesh IPST would lead to significant drawback in parastomal hernia prevention. About 50% patients with permanent colostomy without a prophylactic mesh or with flat mesh (keyhole technique) will have a parastomal hernia (1-4). The results of parastomal hernia repair are poor, leading to recurrencies, re-operations and complications in a number of patients (10). ao vTea Elisa Mkrdinen, M.D. Ph.D. Oulu University hospital, Finland Tero'Rautio, Professor, Chief of Surgery `Oulu University hospital, Finland 1. Ammann Y, Widmann B, Sparn M, Warschkow R, Weitzendorfer M, Brunner W. Prophylactic funnel mesh to prevent parastomal hernia in permanent end colostomy: a retrospective cohort study. Colorectal Dis. 2021,23:2627-2636. 2. L6pez-Borao J, Madrazo-Gonzlez Z, Krefsler , Biondo S. Prevention of parastomal hernia after abdominoperineal excision with a prophylactic three-dimensional funnel mesh. Colorectal Dis; 201921:1326-1334. 3. Bertoglio CL, Maspero M, Morini L, Zironda A, Alampi BD, Mazzola M, Magistro C, Carnevali P, Ferrari G. Permanent end-colostomy parastomal hernia prevention using a novel three-dimensional mesh. Hernia. 2021;25/655-663 4. Berger D. Prevention of parastomal hernias by prophylactic use of a specially designed intraperitoneal onlay mesh (Dynamesh IPST). Hernia. 2008;12:243-6. 5. Odensten C, Strigrd K, Rutegard J, Dahlberg M, Stahle U, Gunnarsson U, Nsvall P. Use of prophylactic mesh when creating a colostomy does not prevent parastomal hernia: A Randomized Controlled Trial-STOMAMESH. Ann Surg. 2019,269:427-431. 6. Prudhomme M, Rullier , Lakkis Z, Cotte E, Panis Y, Meunier B, Rouanet P, TuechJ) Jafari M, Portier G, Dubois A, Sielezneff |, Parc Y, Faucheron JL, Meurette G, Lelong B, Piessen G, Karoui M, Fabbro-Peray P, Demattei C, Bertrand MM; GRECCAR research group. End colostomy with or without mesh to prevent a parastomal hernia (GRECCAR 7). A Prospective, Randomized, Double Blinded, Multicentre Trial. Ann Surg. 2021,274:928-934. 7. Makarinen-Uhlback E, Kintrup KHB, Vierimaa MT, Carpelan-Holmstrm MA, K6ssi JAO, Kairaluoma MV, Ohtonen PP, Tahvonen PR, Rautio TT. Prospective, randomized study on the use of prosthetic mesh to prevent a parastomal hernia in a permanent colostomy: results of a long-term follow-up. Dis Colon Rectum. 2020/63:678-684. 8. Antoniou SA, Agresta F, Garcia Alamino JM, Berger D, Berrevoet F, Brandsma HT, Bury K, Conze J, Cuccurullo D, Dietz UA, Fortelny RH, Frei-Lanter C, Hansson B, Helgstrand F, Hotouras A, Janes A, Kroese LF, Lambrecht JR, Kyle-Leinhase I, Lopez-Cano M, Maggiori L, Mandala V, Miserez M, Montgomery A, Morales-Conde S, Prudhomme M, Rautio T, Smart N, Smietariski M, Szczepkowski M, Stabilini C, Muysoms FE. European Hernia Society guidelines on prevention and treatment of parastomal hernias, Hernia. 201822183198. 9. Makarainen-Uhiback , Wiik H, Kosi J, Nikberg M, Ohtonen P, Rautio T. Chimney Trial: study protocol for a randomized controlled trial Trials. 2019,20:652. 10. Mkrinen-Uhlbick E, Vironen J, Falenius V, Nordstrm P, Valikoski A, Kosi J, Kechagias A, Kalliala M, Mattila A, Rantanen T, Scheinin T, Ohtonen P, Rautio T. Parastomal Hernia: A Retrospective Nationwide Cohort Study Comparing Different Techniques with Long-Term FollowUp. WorldJ Surg. 2021:45:1742-1749.