Document KGdoOogzGOkkYJ1r26ZXJ1qo2

Kay 30, 1975 Dr. Philippe 8hublk; Eppley Institute for Research In Cancer University of Nebraska tend & Dewey Ave. Omaha, Nebraska 68103 Dear Philippe: Please accept our appreciation for your offer to review the material relating to the liver lesions In rats given AROCLOR 1260. As we discussed yesterday, I am sending you several Items-fpx review In advance of our meeting. These Include: 1. Pile memorandum of a meeting between Drs. Kimbrough (CDC), ^Squires (NCI), Gordon and Richter (Industrial BIO-TEST) and Devlnskas (Monsanto). 2, Draft of a manuscript by Kimbrough et al on AROCLOR 1260. 3. Summary and selected pages of Industrial BIO-TEST report (November 12, 1971) on a 2-year rat feeding study with f AROCLOR 1260. 4. Industrial BIO-TEST report (March 24, 1975) on review of liver sections from the study cited as item 2. Under separate cover slides of liver sections for rats sacri ficed after 2 years from the group receiving 100 ppm AROCLOR 126o. Animal numbers are: 724 male ' 766 female 767 female 771 female 789 female Previously reported lesions are described on page 14 of the EX P-3119 Page 1 of 2 02^64^7 PCB-ARCH0746197 Dr. Philippa Shublk May 30, 1&T5 Pag* - 2 - enclosed reference 4. We are prepared to supply you with any additional material you may need for your evaluation. These should present you with a good Indication of our con cern. We would like your recommendations as to what we should do as as result of this Information and your thoughts as to how we might proceed in bringing this information to the atten tion of our customers and various regulatory agencies. As you can note from the affiliations of Dr. Kimbrough's co-authors, many of the latter are already aware of her findings. > We would also appreciate your evaluation of these reports, your / opinion as to whether there are apparent reasons for the dlff/ eront results obtained by the 2 laboratories, your suggestions / regarding possible additional animal testing, and your Judge\ went as to the significance of the findings with respect to \ batards to man. Both Pr. Kimbrough's and BIO-TEST's studies were conducted with the same lot of AROCLOR 1260. Consequently, there should be no differences which could be attributable to Impurities in the test materials. Hie highest feeding level used In the BIO-TEST study (100 ppm) corresponds to the single level used by l>r. Kimbrough. AROCLOR 1260 Is a mixture of homologs and Isomers of biphenyl which haB been chlorinated to an average of 60*. We shall look forward to your suggestions, I will contact you later next week. Kindest personal regards. Sincerely, enol. eet 0. Roush 0. Levlnskas V* Papageorgei Paul L. Wright, PhD Mgr., Toxicology Corporate Medical Department ' EX P-3119 Page 2 of 2 02*6**18 PCB-ARCH0746198