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To: 'Bruce Jarnot' <jarnotb@api.org>; Tom Armstrong (E-mail) <thomas.w.armstrong@exxonmobil.com>; Rob Schnatter (E-mail) <a.r.schnatter@exxonmobil.com>; Yimei Zhou (E-mail) <yimei.x.zhou@exxonmobil.com> From: Cagen, Stuart Z SCC-CF-SS </O=SHE LUOU=MSXSCC/CN=RE CI PI ENTS/CN=SC724012> Cc: John Wagner <Wagner@api.org>; Mark Fitzsimmons (E-mail) <mfitzsim@steptoe.com>; Lorraine Twerdok <Twerdokl@api.org>; Michael Bird (E-mail) <michael.g.bird@exxonmobil.com> Bcc: Received Date: 2004-11-30 18:51 :27 GMT Subject: RE: RSVP Needed: Availability for Exposure Assessment Mtg at EMBSI next week? Looks like the 9th OK? Stuart Cagen Shell Chemical LP One Shell Plaza, 91 0 Louisiana, Houston, TX 77002-4916 Tel: +1 713241 1407 Fax: +1 713241 3325 Other Tel: +1 8326463987 Email: stuart.cagen@shell.com Internet: http://www.shell.com/chemicals -----Original Message----From: Bruce Jarnot [mailto:jarnotb@api.org] Sent: Tuesday, November 30, 2004 12:27 PM To: Tom Armstrong (E-mail); Rob Schnatter (E-mail); Yimei Zhou (E-mail) Cc: John Wagner; Mark Fitzsimmons (E-mail); Cagen, Stuart Z SCC-CF-SS; Lorraine Twerdok; Michael Bird (E-mail) Subject: RSVP Needed: Availability for Exposure Assessment Mtg at EMBSI next week? Exposure Assessment Pis - Stuart Cagen would like to organize a Technical Committee meeting at EMBSI next week (Dec 6-10) to review Exposure Assessment activities & progress under the CC 1 DP 1 ME Shanghai Health Studies... Per Stuart's attached email, please reply by COB tomorrow (Wednesday 12/01) with your availability to join this meeting -- either in person or by conference call -- on the following dates/times: Mon 12/6, 1Oam - 4pm Tue 12/7, 10am - 4pm Wed 12/8, 10am - 4pm Thur 12/9, 10am - 4pm Thanks! Bruce. -----Original Message----From: Cagen, Stuart Z SCC-CF-SS [mailto:stuart.cagen@shell.com] Sent: Tuesday, November 30,200411 :55 AM To: Burnett, Donald M.; michael.g.bird@exxonmobil.com; Beatty, Patrick (PatrickBeatty); Tsai, Shan P SHLOIL-SHS; Stephen Bowes (E-mail); SH ELL-MCCLU RG-064443 Jennifer Galvin (E-mail); Bruce Jarnot Subject: RE: BHRC Technical committee Let's recalibrate a possible meeting date for next week. If we were to meet at EMBSI from 10 am to 4 pm, please let me know your available date(s) for next week: Monday 6 Tues 7 Wed8 Thurs 9 Thanks Stuart Cagen Shell Chemical LP One Shell Plaza, 91 0 Louisiana, Houston, TX 77002-4916 Tel: +1 713241 1407 Fax: +1 713241 3325 Other Tel: +1 8326463987 Email: stuart.cagen@shell.com Internet: http://www.shell.com/chemicals -----Original Message----From: Burnett, Donald M. [mailto:burnetdm@bp.com] Sent: Wednesday, November 24, 2004 1:39 PM To: Cagen, Stuart Z SCC-CF-SS; michael.g.bird@exxonmobil.com; Beatty, Patrick (PatrickBeatty); Tsai, Shan P SHLOIL-SHS; Stephen Bowes (E-mail); Jennifer Galvin (E-mail); Bruce M. Jarnot (E-mail) Subject: RE: BHRC Technical committee My availability on the proposed dates is as follows. Dec 2 - no Dec 6 - yes, by conference call only Dec 7 - no Dec 8 - yes Dec 9 - yes and if needed, Dec 10 - yes Dec 13 - yes Dec 14 - yes Dec 15 - yes Regards, Don Product Stewardship & Toxicology BP phone 630/420-5093 fax 630/420-5375 SH ELL-MCCLU RG-064444 burnetdm @bp. com -----Original Message----From: Cagen, Stuart Z SCC-CF-SS [mailto:stuart.cagen@shell.com] Sent: Tuesday, November 23,20048:26 AM To: michael.g.bird@exxonmobil.com; Beatty, Patrick (PatrickBeatty); Tsai, Shan P SHLOIL-SHS; Stephen Bowes (E-mail); Jennifer Galvin (E-mail); Bruce M. Jarnot (E-mail); Burnett, Donald M. Cc: Clegg, Patsy M SCC-CHSE-PC Subject: RE: BHRC Technical committee All: As per action items for the technical committee and the need to report to the oversight committee on Dec 16, I would suggest the following possible dates for meetings or conference calls as per Michael's offer to arrange something with the exposure team at EMBSI and for a separate meeting with Rich. These are my available dates prior to the Dec 16 meeting: Dec 6,7 (I might also be available on Dec 2,8,9, but I would prefer Dec 6 or 7) Stuart Cagen Shell Chemical LP One Shell Plaza, 91 0 Louisiana, Houston, TX 77002-4916 Tel: +1 713241 1407 Fax: +1 713241 3325 Other Tel: +1 8326463987 Email: stuart.cagen@shell.com Internet: http://www.shell.com/chemicals -----Original Message----From: michael.g.bird@exxonmobil.com [mailto:michael.g.bird@exxonmobil.com] Sent: Monday, November 22, 2004 12:00 PM To: Cagen, Stuart Z SCC-CF-SS Subject: RE: BHRC Technical committee Michael G Bird To: "Beatty, Patrick (PatrickBeatty)" <PatrickBeatty@chevrontexaco.com>, <szcagen@SheII.Com> 11/21/0411 :53 AM cc: <jarnotb@api.org> Subject: RE: BHRC Technical committee(Document link: Michael G Bird) On Friday afternoon (11/19), I sat in on a review by EMBSI management of the EMBSI contract/involvement in the SHS. There were few issues identified that as a Tech Committee member I was not aware, however I came away with a SH ELL-MCCLU RG-06444S much greater appreciation of the EA aspects of the study and operational aspects which impact other study components and in particular gained insight as to the needs and benefits of achieving quantitative exposure assessment for the DP and CC. Also the current lack of success of obtaining bone marrow for ME 2B and likely reasons for this. I think the BHRC Tech Committee would benefit from hearing this directly from Tom, Yimei and Rob. Richard Irons tends to represent and focus on the lab /clinical aspects that's his expertise after all - but with the above EA input, I think the Tech Committee will do a much better assessment of what can be achieved, and $$'s needed, based on the 2 years of study experience. I recommend that we have a conference call (or meeting) with the EA team additional to any visit to Denver and to do this, as soon as possible and before the next Oversight committee on December 12th. My intent is not to exclude Irons as PI - he could participate too - but I believe that our time as a committee focussing on the EA aspect (eg impact on the CC study) with the EA team would be enormously valuable, would provide a better basis for further discussions with the PI's, and for meeting the Oversight committee's expectations. Please call if you want to discuss further or if I can help in convening the above. Michael Michael G. Bird, PhD., DABT Toxicology & Environmental Sciences Division, ExxonMobil Biomedical Sciences, Inc. 1545 Route 22 East P.O. Box 971 Annandale, New Jersey 08801-0971 tel: 9087301060 fax: 908 730 1199 Email: michael.g.bird@exxonmmobil.com SH ELL-MCCLU RG-064446