Document KG0gDZkGEbz1RDQD0qQY2YrBw

THE MOUNT SINAI MEDICAL CENTER ONE GUSTAVE L LEVY PLACE NEW YORK. N.Y. 10029 Of mowuMwnm Mount Sinai School of Medicine *1116 Mount Sinai Hospital Zi \ Irving J. Selikoff. M.D. The Mount Sinai Medical Center 19 East 98th Street, (Bo* 10591 New York. N.Y. 10029 October 12, 1987 (2O^/-7809. 7811 Mr. Robert E. Sweeney Suite 950 55 Public Square Cleveland, OH 44113 Dear Mr. Sweeney: In the continuing academic discussions concerninging short-fiber vs. long fiber asbestos toxicity, I'm not sure that we mentioned the nice original work by Dr. Paul Gross and his colleagues ' who studied the questions. This "was likely of some importance, in view of Dr. Gross's special role at the Industrial Hygiene Foundation Inc. and the value placed on the work of his group by the asbestos industry. . They gave a single intratrachael injectionof short fiber chrysotile experimentally and observed resulting pulmonary fibrosis. (Granulomatous pneumonitis caused by short-fiber asbestos dust (chrysotile), American Journal of Pathology 31:579, T955) "Our findings are confirmatory of the pathogenicity of short-fiber asbestos dust reported E. J. King, Clegg and Rae in rabbits." ' With all best wishes. ___ .... - - Sincerely yours. THE AMERICAN JOURNAL OF PATHOLOGY Ofzdci Publication of ' The American Association of Pathologists and Bacteriologists BOARD OF EDITORS CARL V. WELLER, Ebxtor-ix-Chicf ALVIN J. COX. JR. R. PHILIP CUSTER ERNEST W. GOODPASTURE WEBB E. HAYMAKER HOWARD T. RARSXER SHIELDS WARREN Esitoual Assistant DOROTHY E. SEIFERLEIN t VOLUME XXXI I9S5 ANN ARBOR MICHIGAN U.S.A -t than the total >! initial tourer of "HR in which no -ssion o! previotu *** was presented. in Infants and and St. Chris- i the Out-Patient turned for almost ren in the penod aunnp the first 6 ring months. All * included in this 2omissions. As a of a re-ratting in the remaining iiiesuuons of a :me. The present hese infants and ; the 7? deaths. :rumonia. leptoiaryngoiracoet: the infectious ns were respoc- '-!> associated jc mal/ormaion or perfora>s:5 fetaiis. and n of the deaths, cause of death tsiu' :h>Tuco"luoed test ic oeatn car. be nstoiocic. bac- 4 THE PRODUC- in.i and TV. A. Louis. Me. > of congenital vsttmic to the stenosis and orrnal cardio- inal thickenheart disease nstitute, Issti- :r's :, '4i. ; it *3 1 SCIENTIFIC PROCEEDING? whether a Ieft-to-nght shur.i or pulmonary stenosis was present The incidence was cuniiar in both groups increased with advancing act. and in both asnormai croups as too per emt in acr groups over ic year:. (3 \ Since it is reasonable to assume that the averacc of the puimtmarv arterial pressures in patients with lcft*to*nem shunt wits nicher than in me pat-ems with plenary stenosis, it is apparent that hypertension was not a pnmar.- iactor tn tfcr production of pulmonary trtenosclcrosis in these cases However, the severity of arteriosclerotic lesions was significantly greater in cases with lcit-ir-nch: shum than is those with pulmonary stenosis, sucrounc thai increased pressure and blood flow is these vessels may lie ctiolngic factors oi accessory importance (3} Fibrous intimal lesions were associated with pulmonary arterial thrombi in ys per cent of the cases regardless of the type of anomaly present, succrsunc that thrombi may be a primary factor in the production of these arteriosclerotic lesions. (4) Pulmonary arterial thrombi were of similar frequency in cases with leftto-ribt shunt (25 per cent) and in cases with pulmonary stenosis tt per cent 1. (5; Because potential sources for emboli were iound in 1: cases, an embolic origin of the arterial thrombi can be postulated. (6.1 The transfotmation of a fresh thrombus to ar. arteriosclerotic lesion couid occur through organization of the thrombus and subsequent contraction. Lesions which irresistibly suggest the stages in this process couid be easily iound. EasBousAtnoN or Cerebral Tissue t<* Lungs Foia.ov. ixc Severe Head Injury. James B. McMillan (by invitation 1. Ohio State University. Columbus Ohio. Three cases are reported in which microscopic emboli of cerebral tissue were found in pulmonary arteriole: All 5 patterns died ioliowmc set rre mad injury with skull fractures, gross lacerations of the brain, and traumatic intracerebral hemor rhage. Lung sections showed numerous em'ooii 01 brain tissue distending the pulmo nary arterioles, and in one case the emboiization was accompanied by miarcts c: the June. In all cases glial cells were weli preserved, and neurons and vascular struc tures could be identified in several of the emooii. A total of 10c. complete necropsies were performed during a 1 :-year period or. patients dymr with sever* head injuries giving an incidence of 1.5 per cent for this lesion. Althouch the literature stresses tbr great rarity of its occurrence, the present report would indicate that traumatic embolization of cerebral tissue is not too uncommon. Careful histologic examination of numerous sections 0i the lungs is necessary, and two 0: the present cases-were discovered only alter careful restudy of the necropsy material. The validity oi this report is iurther substantiated by a senes of ammai experiments. r Granulomatous Pneumonitis Caused hv 5KCE7-rissF.tr Asbestos Dust (Cbf.ysottix;. Pan; Gross arc fbv invitation' Maria:. L. We.-irici: and .lame M. McNemry Industnai Hygiene Foundation. Mellon Institute. Pittsburgh. Pa. By a single intratracheal injection in rats of slightly less than to mg of chrysottic fibers substantially shorter than 5 but also including a few longer finer:-. \u have produced soduiar granulomatous lesions leading to pulmonary fibrosis Our findings are confirmatory of the pathogenicity of short-naered asbestos dust reported by E. J. Sing, Clegg, and Rac in rabbits, j Experimental Aspiration Pneumonia: Inflammatory and Reparative Changes Produced iy Intratracheal Injections or Autologous Gastric Juice and Hydrochloric Acn>. T. J. Moran. Presbyterian and Woman's Hospitals. Pitts burg. Pa. The effects of intratracheal injection of homologous gastric juice, hydrochloric add, pepsin, and stcapsin in rabbits have been studied. The changes produced in-