Document K8Zva4QQmYED3r2mrnq7p01X

Younger Laboratories L1'1' Hi 1I 198 CLIFF CAVE ROAD Saint Louie. Mo* 63199 *PHONII TILOKM 6*9540 Gerii^ioaie AmhfAti soviet - Toxloological lareatlgetlaa Oft PTOftAOL T- 9 Noaauto Saaplo NaMer 184 Hauuto Project NaMer T-66-159 Not *t>.r 9th, 1966 snot CONDUCTED roi - Numbto Ceopaajr, St. Laala, Klooouri BPUUHIlfrAL PROCBOU - A) Oral LDjg (Bata, Mlsed Saa) lko aadUated lupoaad mi olbiae solo ud foaala r* to Spragae-Daalap atroia Aftor the pi ftaalo rota lag latorrola uppljiaN Soto aodlfleatioa ko mi deteraiaed, (Toapa of aalo ud t 1 aormmto of 0,1 frootloMl Nloakot tho toxlsltp raage thereby of tho U,( Ml* ai deae aeaordlag to a S. J. 4a Bur. Obaarratlooa wiXOrtytadi apaptoaa a* tho riecere of tho aalula that eooeaMod ooro oxaalaad Merooaoploolly. flit data aro akom la Ihhlo 1. *) Skla Abaorptlra KU> (Nabblta, KUod Sex) Dm aadllatad oupeaad ni applied la laeroaalad dna at laoroouto of 0.2 frootloaol log latoroala to tho eloaely ellppod, latoot Mia of Neo Mite aalo aad ruble rabbito. Tho trootad arou ooro eoeerab olth plaatlo otrlpa oad tho plaaod la oaodu otoMo for porloda ap to treaty-four hoara, after aklah tlao thoj ooro ualMad to ladlvldaal oagaa. Obaorratlou ooro aodo for tula oyaptoaa ood tho rlaoora of the aalaola that amoaahod ooro axulaod Moroeooploelly. Tho data aro ohooa la Table IX. HONS Q3'^7 TW eonlidaniial report la aot to bo ured la aay loire ol advortMac without writtaa paimliMoa Ti Moaaaato Coapany St, Louis, Missouri Younger Laborstorlsa Certificate of Analysis - Pago 2 (11/9/M) - 1-66-159 SUMMARY PYDRAUL r- 9 A) Oral U),o (Rata, Mixed Sax) The Oral LDI4 far aala aad feaals rats saa plaoed at 11,200 allUgraaa par kilagraa with laaar aad uppar Ualta of 9,855 to 12,770 ailligraas par kilagna. Ika ooapound aaa olaaaad aa practically soartoxic by oral lagestioa ia aala aad finale rata. BJ Skia Abaorptlan MLS (Rabbits, Mlxad Sax) lka Hiaiaua Lstbal Doao by Skia Abaorptiaa la aala aad faaala rabblta aaa found to bo groatar thaa 501 allUgraaa par kilagraa aad laaa thaa 794 aUligraaa par kilagraa. The aaapaaad aaa olaaaad aa aadarataly toxia by akia abaorptiaa ia aala aad faaala rabbits. youmcr LAfiORAToaxss in fovmnl publi.ruio:'3. No 0;: may be male without l r " ment in St. "i''11' ; toxicity am to ba referred aa ment in St. Louis for ieply. HONS 03794S Toi Nonaaato Coapaap St. Louie, Misaourl louager Laboratorlea Certificate of Aaalpeie - Fage ) ill/9/66) - r-66-159 ItBU I tiu oral lo,0 or 'rxuMAin, r-9' fob rats Saaple fed Undiluted aalgkt Oa . 1- faaala 2- Hale V faaala 4- Hale V faaala 6- Mala 7- faaala 8. Mala > faaala 10- Mala 11- faaala 12- Mala IV faaala 14- Mala IV faaala 16- Mala IT- Fatale IV Mala IV faaala 20- Mala 215 260 225 240 230 245 220 255 215 250 2)0 245 220 2(0 225 270 2)0 245 225 240 Doee Bit/-!fc 7,540 7.940 7.940 7.940 7,940 10,000 10,000 10,000 10,000 10,000 12,(00 12,600 12,(00 12,(00 12,(00 15,00 15,800 15,800 15.800 15,800 rata Survived Survived Survived Survived Survived Survived Died Survived Mad Survived Died Mad Survived Survived Mad Mad Mad Mad Mad Mad DISCUSSION - Tbe Oral U>,, tar aala aad faaala rota aaa plaead at 11,200 atlUroaa aor klloroa alts lover and upper llalta af 9,855 ta 12,770 eillijraee par kllegraa. Tha ooapouad aaa olaaeed aa praotlaallr aearteaio bp oral lageatlaa la aala aad faaala rota. Survival tlaa vaa too ta five dapa. Toxic apaptaaa locludad vaakaaaa aftar aavaral houra, dlanrhaa, loaa of appatlta, trcaora, aad dpapaaa. At autopap tboro aaa rvaal aad liver kpparaala bp aaoraaaaplo axaalaatloa. HONS 03"49 fill tot Monaaato Ceapaap st. ImUi Missouri Touagir Laborotoriso Cortifioato of Aaalpals - Pag* 4 (11/9/66) - r-66-159 mu 11 TH MINIMUM LJTHA1 OOSii Of 'PTDKAUI, T- V BT SKIN ABSORPTION IN RABBITS Saapla Applisd Undllutsd Aalaal Mo. - sax Haight Kx . Boos iJfcZSfc sight Chaaga 5 Daps Latsr _____ Jbj_____ ______ Jte, 1 - ftaals 2.5 m 2 - Mala 2.6 501 ) finals 2.4 794 4 - Mala 2.8 1260 5 - foaals 2.4 2000 & . Mala 2.6 J10 0.0 Surrirsd 0.2 Survlvid 0.; Dlsd -- 7 0.5 DIM -- 7 0.2 Disd -- 6 0.4 Diod -- } 01BC888X0N - Ths Mlalaoa lethal Daao Bp Bkla Absorptioa la aala aad faala rakblta saa fouad ta ho groator thaa 501 ajUlpraao par kllagraa aad Xaaa thaa 794 ailligruaa par kllagraa. Jhi ooapoaaA saa olaassd as aodsratslp taxis bp skia absorptioa la aala aad fasals rabbits. Survival tlas uas fivo ta moron Saps. Tsxla spaptaaa lasludod lass of appstlto, lothargp, sad aotioaabla ooaknssa la too to thraa daps. At autopop thars saa pulaoaarp hpparsalai othsroiso 00 rlsooral chaagas of ooasaqusaoa saro aotad aaaroaeoploallp. M0NS 037950