Document K6Dbb2yz0w6y8vGajQ7wL7ONK
BIOSEARCH,
INC.
p.c.box 8598 philadelphia,pennsylvania 19101
t e Ie p h c n e
2 1 5 8 4 8 -4 4 9 9
Submitted to:
3M Company 3M Center St. Paul, Minnesota
55101
Material: Sample Received: Date of Report: Test: Object of Test: Method of Test,
Results:
3m Company - T-1585
August 25, 1976
September 16,'1976
Primary Eye IrritationStudy - Rabbits
To determine the degree of irritation,if any, which the subject materi'almay produce when instilledinto the eyes of albino rabbits. This test was performed in order to classify this material under the Federal Hazardous Substances Labeling Act.
The methods employed in the testing, evaluation and in the grading of the test material are those described in Section 1500.42 - Hazardous Substances and Articles, Administration and Enforcement Regulations, Federal Register, Vol. 38, No. 187, P. 27019, 27 September 1973.
The sample was used as supplied.
Six healthy young adult albino rabbits were used in this study. 0.1 gm of the experimental material was instilledinto the righteyes of the test animals while the other eyes remained untreated to serve as controls. The test material was not washed from the eyes.
The treated eyes were examined at 1, 24, 48 & 72 hrs. 5 & 7 days following instillationof the test material into the eyes. Interpretationof the results was made in accordance with the grading system outlined in the "Illustrated Guide for Grading Eye Irritation By Hazardous Substances".
The results of the tests are shown in the accompanying Table which covers each of the animals treated with the test material.
3m Company T-1585, Primary Eye Irritation Study.
Conclusion:
Based on the accompanying table, the sub-
ject materialiS a primaryocular irritant
within the definition of the Act-Reference:
Section j5oo.42(b) (1) (2) P. 27019and requires
cautionary labeling with respect to that section.
Karl L. Gabriel,V.M.D., Ph.D. Director
TABLE I Grades for Ocular Lesions
material: 3M Company - T-1585, as supplied.
Cornea Rabbit No. Opacity Area
1 2 1 hour 3 4
5 6
4
4
4
4
4
4
4
4
4
4
4
4
1 2 24 hours 3 4
5 6
4
4
4
4
4
4
4
4
4
4
4
4
1 2 48 hours 3 4
5 6
4
4
4
4
4
4
4
4
4
4
4
4
1 2 72 hours 3 4
5
4
4
4
4
4
4
4
4
4
4
4
4
2 5 days 3
4
5 6
4
4
4
4
4
4
4
4
4
4
4
4
1 2
7 days 3 4 5 6
4
4
4
4
4
4
4
4
4
4
4
4
Iris
2 2 2 2 2 2
2 2 2 2 2 2
2 2 2 2 2 2
2 2 2 2 2 2
2 2 2 2 2 2
2 2 2 2 2 2
Conjunctivae Redness Chemosis
2
4
2
4
2
4
2
4
2
4
2
4
2
4
2
4
2
4
2
4
2
4
2
4
2
4
2
4
2
4
2
4
2
4
2
4
2
4
2
4
2
4
2
4
2
4
2
4
2
4
2
4
2
4
2
4
2
4
2
4
2
4
2
4
2
4
2
4
2
4
2
4
Discharae
3 3 3 3 3 3
3 3 3 3 3 3
3 3 3 3 3 3
3 3 3 3 3 3
3 3 3 3 3 3
3 3 3 3 3 3